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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 378. Отображено 185.
16-07-2019 дата публикации

Systems and methods for using geometry sensitivity information for guiding workflow

Номер: US0010354349B2
Автор: Sethuraman Sankaran, Leo J. Grady, Charles A. Taylor, SANKARAN SETHURAMAN, GRADY LEO J, TAYLOR CHARLES A, Sankaran, Sethuraman, Grady, Leo J., Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Systems and methods are disclosed for using geometry sensitivity information for guiding workflows in order to produce reliable models and quantities of interest. One method includes determining a geometric model associated with a target object; determining one or more quantities of interest; determining sensitivity information associated with one or more subdivisions of the geometric model and the one or more quantities of interest; and generating, using a processor, a workflow based on the sensitivity information.

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Номер записи: 1
01-12-2015 дата публикации

Systems and methods for modeling changes in patient-specific blood vessel geometry and boundary conditions

Номер: US0009202010B2
Автор: Charles A. Taylor, Hyun Jin Kim, Sethuraman Sankaran, Michiel Schaap, David Eberle, Gilwoo Choi, Leo Grady, TAYLOR CHARLES A, KIM HYUN JIN, SANKARAN SETHURAMAN, SCHAAP MICHIEL, EBERLE DAVID, CHOI GILWOO, GRADY LEO, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC, HEARTFLOW, INC.

Systems and methods are disclosed for modeling changes in patient-specific blood vessel geometry and boundary conditions resulting from changes in blood flow or pressure. One method includes determining, using a processor, a first anatomic model of one or more blood vessels of a patient; determining a biomechanical model of the one or more blood vessels based on at least the first anatomic model; determining one or more parameters associated with a physiological state of the patient; and creating a second anatomic model based on the biomechanical model and the one or more parameters associated with the physiological state.

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Номер записи: 2
09-01-2018 дата публикации

Systems and methods for embolism prediction using embolus source and destination probabilities

Номер: US0009864840B2
Автор: Leo Grady, Gilwoo Choi, Charles A. Taylor, Christopher K. Zarins, GRADY LEO, CHOI GILWOO, TAYLOR CHARLES A, ZARINS CHRISTOPHER K, Grady Leo, Choi Gilwoo, Taylor Charles A., Zarins Christopher K.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Systems and methods are disclosed for determining a patient risk assessment or treatment plan based on emboli dislodgement and destination. One method includes receiving a patient-specific anatomic model generated from patient-specific imaging of at least a portion of a patient's vasculature; determining or receiving a location of interest in the patient-specific anatomic model of the patient's vasculature; using a computing processor for calculating blood flow through the patient-specific anatomic model to determine blood flow characteristics through at least the portion of the patient's vasculature of the patient-specific anatomic model downstream from the location of interest; and using a computing processor for particle tracking through the simulated blood flow to determine a destination probability of an embolus originating from the location of interest in the patient-specific anatomic model, based on the determined blood flow characteristics.

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Номер записи: 3
14-03-2023 дата публикации

Systems and methods for assessment of tissue function based on vascular disease

Номер: US0011605466B2
Автор: Leo Grady, Charles A. Taylor
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed for assessing tissue function based on vascular disease. One method includes receiving a patient-specific anatomic model generated from patient-specific imaging of at least a portion of a patient's tissue; receiving a patient-specific vascular model generated from patient-specific imaging of at least a portion of a patient's vasculature; receiving an estimate of blood supplied to a portion of the patient-specific anatomic model; and determining a characteristic of the function of the patient's tissue using the estimate of blood supplied to the portion of the patient-specific anatomic model.

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Номер записи: 4
21-04-2016 дата публикации

METHOD AND SYSTEM FOR IMAGE PROCESSING TO DETERMINE PATIENT-SPECIFIC BLOOD FLOW CHARACTERISTICS

Номер: US20160110867A1
Автор: Charles A. Taylor
Принадлежит: HeartFlow, Inc.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A method of image analysis to produce a mammalian vascular state score , the method comprising:receiving vascular image data including: relative positions in one or more two-dimensional angiographic images of a plurality of vascular segments linked by branch points, and at least one lesion for which a respective lesion complexity includes a degree of stenosis;determining automatically a plurality of lesion complexity-related vascular metrics for each of a plurality of said vascular segments, based on at least one angiographic image of said received image data;determining said lesion complexity for use as an at least one subscore of a vascular state scoring tool, wherein the lesion complexity is based on said plurality of vascular metrics; anddetermining said vascular state score based on said at least one subscore.186. The method of claim 185 , wherein said determining of said lesion complexity-related vascular metrics comprises determination of a vascular cross-sectional area for one or more vascular segments of the plurality of vascular segments.187. The method of claim 185 , wherein said vascular metrics comprise a metric which is a function of vascular segment position.188. The method of claim 185 , wherein said vascular image data images the arterial vasculature of the heart.189. The method of claim 185 , ...

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Номер записи: 5
26-05-2015 дата публикации

Systems and methods for identifying personalized vascular implants from patient-specific anatomic data

Номер: US0009043191B2
Автор: Leo Grady, Charles A. Taylor, Gilwoo Choi, Campbell Rogers, GRADY LEO, TAYLOR CHARLES A, CHOI GILWOO, ROGERS CAMPBELL, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC, HEARTFLOW, INC.

Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising: generating a patient specific model of at least a portion of a patient's vasculature from image data of the patient's vasculature and one or more measured or estimated physiological or phenotypic parameters of the patient; determining pathology characteristics from cardiovascular geometry of the patient specific model; defining an objective function for a device based on design considerations and one or more estimates of hemodynamic and mechanical characteristics; optimizing the objective function, by simulating at least one change in devices and evaluating the objective function using fluid dynamic or structural mechanic analysis; and using the optimized objective function to either (i) select a device from a set of available devices or (ii) manufacture a desired device.

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Номер записи: 6
24-11-2015 дата публикации

Systems and methods for treatment planning based on plaque progression and regression curves

Номер: US0009195801B1
Автор: Sethuraman Sankaran, Charles A. Taylor, Gilwoo Choi, Michiel Schaap, Christopher K. Zarins, Leo J. Grady, SANKARAN SETHURAMAN, TAYLOR CHARLES A, CHOI GILWOO, SCHAAP MICHIEL, ZARINS CHRISTOPHER K, GRADY LEO J, TAYLOR CHARLES A., ZARINS CHRISTOPHER K., GRADY LEO J.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC, HEARTFLOW, INC.

Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of a location of disease in the patient's vasculature based on the received patient-specific data; identifying one or more changes in geometry of the anatomic model based on a modeled progression or regression of disease at the location; calculating one or more values of a blood flow characteristic within the patient's vasculature using a computational model based on the identified one or more changes in geometry of the anatomic model; and generating an electronic graphical display of a relationship between the one or more values of the calculated blood flow characteristic and the identified one or more changes in geometry of the anatomic model.

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Номер записи: 7
18-06-2015 дата публикации

SYSTEMS AND METHODS FOR PREDICTING CORONARY PLAQUE VULNERABILITY FROM PATIENT-SPECIFIC ANATOMIC IMAGE DATA

Номер: US20150164342A1
Автор: Gilwoo CHOI, Leo J. GRADY, Michiel SCHAAP, Charles A. Taylor, CHOI GILWOO, GRADY LEO J, SCHAAP MICHIEL, TAYLOR CHARLES A, GRADY LEO J., TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed for predicting coronary plaque vulnerability, using a computer system. One method includes acquiring anatomical image data of at least part of the patient's vascular system; performing, using a processor, one or more image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical image data; predicting, using the processor, a coronary plaque vulnerability present in the patient's vascular system, wherein predicting the coronary plaque vulnerability includes calculating an adverse plaque characteristic based on results of the one or more of image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis of the anatomical image data; and reporting, using the processor, the calculated adverse plaque characteristic.

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Номер записи: 8
22-03-2018 дата публикации

System And Methods For Estimation Of Blood Flow Characteristics Using Reduced Order Model And Machine Learning

Номер: US20180078139A1
Автор: Travis Michael Sanders, Sethuraman Sankaran, Leo Grady, David Spain, Nan Xiao, Jin Kim, Charles A. Taylor
Принадлежит:

Systems and methods are disclosed for determining blood flow characteristics of a patient. One method includes: receiving, in an electronic storage medium, patient-specific image data of at least a portion of vasculature of the patient having geometric features at one or more points; generating a patient-specific reduced order model from the received image data, the patient-specific reduced order model comprising estimates of impedance values and a simplification of the geometric features at the one or more points of the vasculature of the patient; creating a feature vector comprising the estimates of impedance values and geometric features for each of the one or more points of the patient-specific reduced order model; and determining blood flow characteristics at the one or more points of the patient-specific reduced order model using a machine learning algorithm trained to predict blood flow characteristics based on the created feature vectors at the one or more points. 1. A computer-implemented method of determining blood flow characteristics of a patient , the method comprising:receiving, in an electronic storage medium, patient-specific image data of at least a portion of vasculature of the patient having geometric features at one or more points;generating a patient-specific reduced order model from the received image data, the patient-specific reduced order model comprising estimates of impedance values and a simplification of the geometric features at the one or more points of the vasculature of the patient;creating a feature vector comprising the estimates of impedance values and geometric features for each of the one or more points of the patient-specific reduced order model; anddetermining blood flow characteristics at the one or more points of the patient-specific reduced order model using a machine learning algorithm trained to predict blood flow characteristics based on the created feature vectors at the one or more points.2. The computer-implemented ...

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Номер записи: 9
14-07-2015 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US0009078564B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC, HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 10
09-01-2018 дата публикации

Method and system for image processing to determine patient-specific blood flow characteristics

Номер: US0009861284B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 11
14-07-2015 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US0009081882B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc, HEARTFLOW INC, HEARTFLOW, INC., HEARTFLOW, INC

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 12
14-01-2014 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US0008630812B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC, HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 13
21-08-2012 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US0008249815B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc., TAYLOR CHARLES A, HEARTFLOW INC, TAYLOR CHARLES A., HEARTFLOW, INC.

Embodiments include a system for planning treatment for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of an anatomical structure of the patient, create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data, and determine a first fractional flow reserve within the anatomical structure of the patient based on the three-dimensional model and information regarding a physiological condition of the patient. The at least one computer system may be further configured to receive input from a user regarding a plan of treatment, modify the physiological condition of the patient based on the received input, and determine a second fractional flow reserve within the anatomical structure of the patient based on the modified physiological condition of the patient.

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Номер записи: 14
05-03-2024 дата публикации

Systems and methods for assessing organ and/or tissue transplantation by simulating one or more transplant characteristics

Номер: US0011918293B2
Автор: Leo Grady, Charles A. Taylor, Christopher Zarins
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed for assessing organ and/or tissue transplantation by estimating blood flow through a virtual transplant model by receiving a patient-specific anatomical model of the intended transplant recipient; receiving a patient-specific anatomical model of the intended transplant donor, the model including the vasculature of the organ or tissue that is intended to be transplanted to the recipient; constructing a unified model of the connected system post transplantation, the connected system including the transplanted organ or tissue from the intended transplant donor and the vascular system of the intended transplant recipient; receiving one or more blood flow characteristics of the connected system; assessing the suitability for an actual organ or tissue transplantation using the received blood flow characteristics; and outputting the assessment into an electronic storage medium or display.

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Номер записи: 15
18-12-2018 дата публикации

Method and system for image processing and patient-specific modeling of blood flow

Номер: US0010154883B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 16
01-01-2019 дата публикации

Method and system for image processing to determine patient-specific blood flow characteristics

Номер: US0010166077B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 17
16-04-2019 дата публикации

Systems and methods for predicting perfusion deficits from physiological, anatomical, and patient characteristics

Номер: US0010262101B2
Автор: Leo Grady, Michiel Schaap, Charles A. Taylor, Clara Jaquet, GRADY LEO, SCHAAP MICHIEL, TAYLOR CHARLES A, JAQUET CLARA, Grady, Leo, Schaap, Michiel, Taylor, Charles A., Jaquet, Clara
Принадлежит: HEARTFLOW, INC., HEARTFLOW INC, HeartFlow, Inc.

Systems and methods are disclosed for using patient specific anatomical models and physiological parameters to estimate perfusion of a target tissue to guide diagnosis or treatment of cardiovascular disease. One method includes receiving a patient-specific vessel model and a patent-specific tissue model of a patient anatomy; extracting one or more patient-specific physiological parameters (e.g. blood flow, anatomical characteristics, image characteristics, etc.) from the vessel or tissue models for one or more physiological states of the patient; estimating a characteristic of the perfusion of the patient-specific tissue model (e.g., via a trained machine learning algorithm) using the patient-specific physiological parameters; and outputting the estimated perfusion characteristic to a display.

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Номер записи: 18
20-09-2016 дата публикации

Systems and methods for virtual contrast agent simulation and computational fluid dynamics (CFD) to compute functional significance of stenoses

Номер: US0009449145B2
Автор: Sethuraman Sankaran, Leo J. Grady, Charles A. Taylor, SANKARAN SETHURAMAN, GRADY LEO J, TAYLOR CHARLES A, Sankaran Sethuraman, Grady Leo J., Taylor Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Systems and methods are disclosed for assessing a risk of disease. One method includes obtaining an anatomic model associated with a target anatomy; modeling, using a processor, an injection of one or more virtual contrast agents into the anatomic model; performing a simulation of flow of blood and the one or more virtual contrast agents through the anatomic model; and computing one or more characteristics of concentration associated with the one or more virtual contrast agents at one or more locations in the anatomic model based on the simulation.

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Номер записи: 19
15-06-2021 дата публикации

Method and system for image processing to determine blood flow

Номер: US0011033332B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC, HeartFlow Inc.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 20
04-07-2017 дата публикации

Method and system for image processing to determine patient-specific blood flow characteristics

Номер: US0009697330B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor Charles A.
Принадлежит: HEARTFLOW, INC., HEARTFLOW INC, HeartFlow, Inc.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 21
02-04-2024 дата публикации

Systems and methods for identifying and modeling unresolved vessels in image-based patient-specific hemodynamic models

Номер: US0011948695B2
Автор: Charles A. Taylor, Hyun Jin Kim, Leo Grady, Rhea Tombropoulos, Gilwoo Choi, Nan Xiao, David Spain
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed for identifying and modeling unresolved vessels, and the effects thereof, in image-based patient-specific hemodynamic models. One method includes: receiving, in an electronic storage medium, one or more patient-specific anatomical models representing at least a vessel of a patient; determining, using a processor, the values and characteristics of one or more patient-specific morphometric features in the one or more patient-specific anatomical models; modifying the patient-specific anatomical model using the determined patient-specific morphometric features; and outputting, one or more of, a modified patient-specific anatomical model or a patient-specific morphometric feature to an electronic storage medium or display.

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Номер записи: 22
26-09-2017 дата публикации

Systems and methods for using geometry sensitivity information for guiding workflow

Номер: US0009773219B2
Автор: Sethuraman Sankaran, Leo J. Grady, Charles A. Taylor, SANKARAN SETHURAMAN, GRADY LEO J, TAYLOR CHARLES A, Sankaran Sethuraman, Grady Leo J., Taylor Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Systems and methods are disclosed for using geometry sensitivity information for guiding workflows in order to produce reliable models and quantities of interest. One method includes determining a geometric model associated with a target object; determining one or more quantities of interest; determining sensitivity information associated with one or more subdivisions of the geometric model and the one or more quantities of interest; and generating, using a processor, a workflow based on the sensitivity information.

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Номер записи: 23
23-06-2020 дата публикации

Systems and methods for estimating hemodynamic forces acting on plaque and monitoring patient risk

Номер: US0010692608B2
Автор: Bon-Kwon Koo, Gilwoo Choi, Hyun Jin Kim, Charles A. Taylor, KOO BON-KWON, CHOI GILWOO, KIM HYUN JIN, TAYLOR CHARLES A, Koo, Bon-Kwon, Choi, Gilwoo, Kim, Hyun Jin, Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Computer-implemented methods are disclosed for estimating values of hemodynamic forces acting on plaque or lesions. One method includes: receiving one or more patient-specific parameters of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion; constructing a patient-specific geometric model of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion, using the received one or more patient-specific parameters; estimating, using one or more processors, the values of hemodynamic forces at one or more points on the patient-specific geometric model, using the patient-specific parameters and geometric model by measuring, deriving, or obtaining one or more of a pressure gradient and a radius gradient; and outputting the estimated values of hemodynamic forces to an electronic storage medium. Systems and computer readable media for executing these methods are also disclosed.

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Номер записи: 24
19-03-2020 дата публикации

SYSTEMS AND METHODS FOR TREATMENT PLANNING BASED ON PLAQUE PROGRESSION AND REGRESSION CURVES

Номер: US20200085501A1
Автор: Sethuraman Sankaran, Charles A. Taylor, Gilwoo Choi, Michiel Schaap, Christopher K. Zarins, Leo Grady, SANKARAN SETHURAMAN, TAYLOR CHARLES A, CHOI GILWOO, SCHAAP MICHIEL, ZARINS CHRISTOPHER K, GRADY LEO, Sankaran, Sethuraman, Taylor, Charles A., Choi, Gilwoo, Schaap, Michiel, Zarins, Christopher K., Grady, Leo
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of a location of disease in the patient's vasculature based on the received patient-specific data; identifying one or more changes in geometry of the anatomic model based on a modeled progression or regression of disease at the location; calculating one or more values of a blood flow characteristic within the patient's vasculature using a computational model based on the identified one or more changes in geometry of the anatomic model; and generating an electronic graphical display of a relationship between the one or more values of the calculated blood flow characteristic and the identified one or more changes in geometry of the anatomic model. 120-. (canceled)21. A computer-implemented method of evaluating a patient with vascular disease , the method comprising:receiving patient-specific data regarding a geometry of the patient's vasculature;creating an anatomic model representing at least a portion of a location of a disease in the patient's vasculature based on the received patient-specific data;determining a composition of the disease; andupdating the geometry of the created anatomic model, based on the determined composition of the disease.22. The computer-implemented method of claim 21 , wherein the disease comprises an area of plaque in the patient's vasculature claim 21 , andthe composition of the disease comprises the plaque composition, a change in the plaque composition, or a combination thereof.23. The computer-implemented method of claim 21 , where the step of updating the geometry of the created anatomic mode; further comprises:predicting a growth potential of the disease based on the composition of the disease; andupdating the geometry of the created anatomic model further based on the predicted growth ...

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Номер записи: 25
16-02-2012 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20120041324A1
Автор: Charles A. Taylor, Timothy A. Fonte, Christopher K. Zarins, TAYLOR CHARLES A, FONTE TIMOTHY A, ZARINS CHRISTOPHER K, TAYLOR CHARLES A., FONTE TIMOTHY A., ZARINS CHRISTOPHER K.
Принадлежит: HeartFlow, Inc.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1161-. (canceled)162. A system for determining cardiovascular information for a patient , the system comprising: ["receive patient-specific data regarding a geometry of the patient's brain;", "create a three-dimensional model representing at least a portion of the patient's brain based on the patient-specific data; and", "determine information regarding a blood flow characteristic within the patient's brain based on the three-dimensional model and a physics-based model relating to the patient's brain."], 'at least one computer system configured to163. The system of claim 162 , wherein the three-dimensional model representing at least the portion of the patient's brain includes at least a portion of a plurality of cerebral arteries.164. The system of claim 163 , wherein the blood flow characteristic includes at least one of blood flow claim 163 , blood pressure claim 163 , or blood velocity at a plurality of locations within the plurality of cerebral arteries.165. The system of claim 162 , wherein the patient-specific data includes imaging data.166. The system of claim 165 , wherein the imaging data is provided of at least one of at least a portion of an extracranial artery claim 165 , at least a portion of an intracranial artery claim 165 , or brain tissue.167. The system of claim 165 , wherein the imaging data is provided by computer ...

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Номер записи: 26
16-07-2019 дата публикации

Systems and methods for modeling changes in patient-specific blood vessel geometry and boundary conditions

Номер: US0010354759B2
Автор: Charles A. Taylor, Hyun Jin Kim, Sethuraman Sankaran, Michiel Schaap, David Eberle, Gilwoo Choi, Leo Grady, TAYLOR CHARLES A, KIM HYUN JIN, SANKARAN SETHURAMAN, SCHAAP MICHIEL, EBERLE DAVID, CHOI GILWOO, GRADY LEO, Taylor, Charles A., Kim, Hyun Jin, Sankaran, Sethuraman, Schaap, Michiel, Eberle, David, Choi, Gilwoo, Grady, Leo
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Systems and methods are disclosed for modeling changes in patient-specific blood vessel geometry and boundary conditions resulting from changes in blood flow or pressure. One method includes determining, using a processor, a first anatomic model of one or more blood vessels of a patient; determining a biomechanical model of the one or more blood vessels based on at least the first anatomic model; determining one or more parameters associated with a physiological state of the patient; and creating a second anatomic model based on the biomechanical model and the one or more parameters associated with the physiological state.

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Номер записи: 27
27-08-2019 дата публикации

Systems and methods for automatically determining myocardial bridging and patient impact

Номер: US0010395776B2
Автор: Gilwoo Choi, Charles A. Taylor, CHOI GILWOO, TAYLOR CHARLES A, Choi, Gilwoo, Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Embodiments include computer-implemented methods and systems for reporting the presence of myocardial bridging in a patient, the method comprising detecting, within a patient-specific model representing at least a portion of the patient's heart based on patient-specific anatomical image data regarding a geometry of the patient's heart, a segment of an epicardial coronary artery at least partially surrounded by the patient's myocardium to determine the presence of myocardial bridging; and computing, using at least one computer processor, at least one physical feature of the myocardial bridging to identify the severity of the myocardial bridging.

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Номер записи: 28
27-05-2014 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US0008734356B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc., TAYLOR CHARLES A, HEARTFLOW INC, TAYLOR CHARLES A., HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 29
21-07-2020 дата публикации

Systems and methods for cardiovascular blood flow and musculoskeletal modeling for predicting device failure or clinical events

Номер: US0010716513B2
Автор: Gilwoo Choi, Charles A. Taylor, Leo J. Grady, CHOI GILWOO, TAYLOR CHARLES A, GRADY LEO J, Choi, Gilwoo, Taylor, Charles A., Grady, Leo J.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Computer-implemented methods are disclosed for assessing the effect of musculoskeletal activities on disease and/or clinical events, the method comprising: receiving a patient-specific vascular and musculoskeletal model of a patient's anatomy, including at least one vessel of the patient; receiving at least one characteristic of the patient's musculoskeletal activity; generating or updating a computational anatomic vascular and musculoskeletal model of the patient's anatomy based on the received at least one characteristic of musculoskeletal activity; performing at least one of a computational fluid dynamics analysis or a structural mechanics simulation on the computational anatomic vascular and musculoskeletal model; and estimating at least one of the patient's risk of disease or clinical events based on the performed computational fluid dynamics analysis and/or structural mechanics simulation. Systems and computer readable media for executing these methods are also disclosed.

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Номер записи: 30
23-02-2017 дата публикации

METHOD AND SYSTEM FOR IMAGE PROCESSING AND PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20170053092A1
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor Charles A.
Принадлежит: HeartFlow, Inc.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A method for the identification of supply areas , comprising:determining a physiological model of an anatomical region containing blood vessels, the physiological model including at least one geometric parameter and functional parameters;adjusting the physiological model on the basis of patient-specific 3D image data of the anatomical region;simulating the 3D perfusion of the anatomical region on the basis of the adjusted physiological model; andidentifying supply areas of the anatomical region on the basis of the simulation.186. The method of claim 185 , wherein the 3D extent of the blood vessels relative to the anatomical region is adjusted as a first geometric parameter on the basis of the patient-specific 3D image data.187. The method of claim 186 , wherein at least one size of one of the blood vessels is adjusted as a second geometric parameter on the basis of the patient-specific 3D image data.188. The method of claim 185 , wherein the physiological model comprises a 3D structure of the anatomical region.189. The method of claim 188 , wherein the anatomical region is at least a part of the heart of the patient claim 188 , and wherein the 3D surface structure of the heart is adjusted as a geometric parameter.190. The method of claim 185 , wherein the supply areas are identified as 3D supply areas.191. The ...

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Номер записи: 31
11-06-2019 дата публикации

Systems and methods for providing personalized estimates of bioheat transfer

Номер: US0010314655B2
Автор: Leo Grady, Charles A. Taylor, Christopher K. Zarins, GRADY LEO, TAYLOR CHARLES A, ZARINS CHRISTOPHER K, Grady, Leo, Taylor, Charles A., Zarins, Christopher K.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Systems and methods are disclosed for providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model including at least a portion of tissue of the patient's anatomy; receiving an estimate of heat content of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue; determining an estimate of heat distribution of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue based on the vascular model, the tissue model, or the received estimate of heat content; and output the determined estimate of heat distribution to a storage medium or user display.

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Номер записи: 32
24-11-2015 дата публикации

Systems and methods for identifying personalized vascular implants from patient-specific anatomic data

Номер: US0009195800B2
Автор: Leo Grady, Charles A. Taylor, Gilwoo Choi, Campbell Rogers, GRADY LEO, TAYLOR CHARLES A, CHOI GILWOO, ROGERS CAMPBELL, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC, HEARTFLOW, INC.

Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising acquiring a geometric model of at least a portion of a patient's vascular system; obtaining one or more geometric quantities of one or more blood vessels of the geometric model of the patient's vascular system; determining the presence or absence of a pathology characteristic at a location in the geometric model of the patient's vascular system; generating an objective function defined by a plurality of device variables and a plurality of hemodynamic and solid mechanics characteristics; and optimizing the objective function using computational fluid dynamics and structural mechanics analysis to identify a plurality of device variables that result in desired hemodynamic and solid mechanics characteristics.

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Номер записи: 33
31-12-2019 дата публикации

Systems and methods for treatment planning based on plaque progression and regression curves

Номер: US0010517677B2
Автор: Sethuraman Sankaran, Charles A. Taylor, Gilwoo Choi, Michiel Schaap, Christopher K. Zarins, Leo Grady, SANKARAN SETHURAMAN, TAYLOR CHARLES A, CHOI GILWOO, SCHAAP MICHIEL, ZARINS CHRISTOPHER K, GRADY LEO, Sankaran, Sethuraman, Taylor, Charles A., Choi, Gilwoo, Schaap, Michiel, Zarins, Christopher K., Grady, Leo
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of a location of disease in the patient's vasculature based on the received patient-specific data; identifying one or more changes in geometry of the anatomic model based on a modeled progression or regression of disease at the location; calculating one or more values of a blood flow characteristic within the patient's vasculature using a computational model based on the identified one or more changes in geometry of the anatomic model; and generating an electronic graphical display of a relationship between the one or more values of the calculated blood flow characteristic and the identified one or more changes in geometry of the anatomic model.

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Номер записи: 34
31-03-2020 дата публикации

Systems and methods for anatomical modeling using information obtained from a medical procedure

Номер: US0010607739B2
Автор: Leo Grady, Charles A. Taylor, Campbell Rogers, Christopher K. Zarins, Gilwoo Choi, GRADY LEO, TAYLOR CHARLES A, ROGERS CAMPBELL, ZARINS CHRISTOPHER K, CHOI GILWOO, Grady, Leo, Taylor, Charles A., Rogers, Campbell, Zarins, Christopher K., Choi, Gilwoo
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Systems and methods are disclosed herein for anatomical modeling using information obtained during a medical procedure, whereby an initial anatomical model is generated or obtained, a correspondence is determined between the initial model and additional data and/or measurements from an invasive or noninvasive procedure, and, if a discrepancy is found between the initial model and the additional data, the anatomical model is updated to incorporate the additional data and reduce the discrepancy.

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Номер записи: 35
23-02-2023 дата публикации

SYSTEMS AND METHODS FOR PROCESSING ELECTRONIC IMAGES AND UPDATING BASED ON SENSOR DATA

Номер: US20230055828A1
Автор: Timothy A. Fonte, Leo Grady, Charles A. Taylor
Принадлежит:

Systems and methods are disclosed for informing and monitoring blood flow calculations with user-specific activity data, including sensor data. One method includes receiving or accessing a user-specific anatomical model and a first set of physiological characteristics of a user; calculating a first value of a blood flow metric of the user based on the user-specific anatomical model and the first set of physiological characteristics; receiving or calculating a second set of physiological characteristics of the user by accessing or receiving sensor data of the user's blood flow and/or sensor data of the user's physiological characteristics; and calculating second value of the blood flow metric of the user based on the user-specific anatomical model and the second set of physiological characteristics of the user.

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Номер записи: 36
12-01-2016 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US0009235679B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC, HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 37
29-12-2016 дата публикации

IMAGE PROCESSING METHOD FOR DETERMINING PATIENT-SPECIFIC CARDIOVASCULAR INFORMATION

Номер: US20160378947A1
Автор: Charles A. Taylor, Hyun Jin Kim, Jessica S. Coogan, TAYLOR CHARLES A, KIM HYUN JIN, COOGAN JESSICA S, Taylor Charles A., Kim Hyun Jin, Coogan Jessica S.
Принадлежит:

A noninvasive patient-specific method is provided to aid in the analysis, diagnosis, prediction or treatment of hemodynamics of the cardiovascular system of a patient. Coronary blood flow and pressure can be predicted using a 3-D patient image-based model that is implicitly coupled with a model of at least a portion of the remaining cardiovascular system. The 3-D patient image-based model includes at least a portion of the thoracic aorta and epicardial coronaries of the patient. The shape of one or more velocity profiles at the interface of the models is enforced to control complex flow features of recirculating or retrograde flow thereby minimizing model instabilities and resulting in patient-specific predictions of coronary flow rate and pressure. The invention allows for patient-specific predictions of the effect of different or varying physiological states and hemodynamic benefits of coronary medical interventions, percutaneous coronary interventions and surgical therapies.

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Номер записи: 38
14-09-2021 дата публикации

Method and system for image processing to determine blood flow

Номер: US0011116575B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 39
25-06-2024 дата публикации

Method and system for image processing to determine blood flow

Номер: US0012016635B2
Автор: Charles A. Taylor
Принадлежит: HeartFlow, Inc.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 40
23-08-2016 дата публикации

Method and system for sensitivity analysis in modeling blood flow characteristics

Номер: US0009424395B2
Автор: Sethuraman Sankaran, Leo Grady, Charles A. Taylor, SANKARAN SETHURAMAN, GRADY LEO, TAYLOR CHARLES A, Sankaran Sethuraman, Grady Leo, Taylor Charles A.
Принадлежит: HeartFlow, Inc., SANKARAN SETHURAMAN, GRADY LEO, TAYLOR CHARLES A, HEARTFLOW INC, Sankaran Sethuraman, Grady Leo, Taylor Charles A.

Methods for determining cardiovascular information for a patient include receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of the patient's vasculature based on the patient-specific data; and creating a computational model of a blood flow characteristic based on the anatomic model. The method also includes identifying one or more of an uncertain parameter, an uncertain clinical variable, and an uncertain geometry; modifying a probability model based on one or more of the identified uncertain parameter, uncertain clinical variable, or uncertain geometry; determining a blood flow characteristic within the patient's vasculature based on the anatomic model and the computational model; and calculating, based on the probability model and the determined blood flow characteristic, a sensitivity of the determined fractional flow reserve to one or more of the identified uncertain parameter, uncertain clinical ...

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Номер записи: 41
16-07-2019 дата публикации

Image processing method for determining patient-specific cardiovascular information

Номер: US0010354050B2
Автор: Charles A. Taylor, Hyun Jin Kim, Jessica S. Coogan, TAYLOR CHARLES A, KIM HYUN JIN, COOGAN JESSICA S, Taylor, Charles A., Kim, Hyun Jin, Coogan, Jessica S.
Принадлежит: THE BOARD OF TRUSTEES OF LELAND STANFORD JUNIOR UNIVERSITY, UNIV LELAND STANFORD JUNIOR, THE BOARD OF TRUSTEES OF LELAND STANFORD JUNIOR UNIV, BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

A noninvasive patient-specific method is provided to aid in the analysis, diagnosis, prediction or treatment of hemodynamics of the cardiovascular system of a patient. Coronary blood flow and pressure can be predicted using a 3-D patient image-based model that is implicitly coupled with a model of at least a portion of the remaining cardiovascular system. The 3-D patient image-based model includes at least a portion of the thoracic aorta and epicardial coronaries of the patient. The shape of one or more velocity profiles at the interface of the models is enforced to control complex flow features of recirculating or retrograde flow thereby minimizing model instabilities and resulting in patient-specific predictions of coronary flow rate and pressure. The invention allows for patient-specific predictions of the effect of different or varying physiological states and hemodynamic benefits of coronary medical interventions, percutaneous coronary interventions and surgical therapies.

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Номер записи: 42
16-06-2020 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US0010682180B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patients heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 43
21-08-2014 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20140236492A1
Автор: Charles A. Taylor, TAYLOR CHARLES A, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A system for determining cardiovascular information for a patient , the system comprising:at least one computer system configured to:receive patient-specific data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of one or more coronary arteries;create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data;determine a myocardial mass of the patient based on the patient-specific data;estimate total coronary blood flow of the patient based on the determined myocardial mass;create a reduced-order blood flow model relating to a blood flow characteristic within the portion of the anatomical structure based, at least in part, on the estimated total coronary blood flow and the three-dimensional model; anddetermine a value of a fractional flow reserve at each of a plurality of locations within the portion of the anatomical structure based on one or more solutions of the reduced-order blood flow model.186. The system of claim 185 , wherein the total coronary blood flow is one of a hyperemic total coronary blood flow and a resting total coronary blood flow.187. The system of claim 185 , wherein the computer system is configured to create the three-dimensional model by ...

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Номер записи: 44
17-04-2012 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US0008157742B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc., TAYLOR CHARLES A, HEARTFLOW INC, TAYLOR CHARLES A., HEARTFLOW, INC.

Embodiments include a system for planning treatment for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of an anatomical structure of the patient, create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data, and determine a first fractional flow reserve within the anatomical structure of the patient based on the three-dimensional model and a physics-based model relating to the anatomical structure of the patient. The at least one computer system may be further configured to modify the three-dimensional model, and determine a second fractional flow reserve within the anatomical structure of the patient based on the modified three-dimensional model.

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Номер записи: 45
13-06-2017 дата публикации

Systems and methods for predicting location, onset, and/or change of coronary lesions

Номер: US0009679374B2
Автор: Gilwoo Choi, Leo Grady, Charles A. Taylor, CHOI GILWOO, GRADY LEO, TAYLOR CHARLES A, Choi Gilwoo, Grady Leo, Taylor Charles A.
Принадлежит: HEARTFLOW, INC., HEARTFLOW INC, HeartFlow, Inc.

Systems and methods are disclosed for predicting the location, onset, or change of coronary lesions from factors like vessel geometry, physiology, and hemodynamics. One method includes: acquiring, for each of a plurality of individuals, a geometric model, blood flow characteristics, and plaque information for part of the individual's vascular system; training a machine learning algorithm based on the geometric models and blood flow characteristics for each of the plurality of individuals, and features predictive of the presence of plaque within the geometric models and blood flow characteristics of the plurality of individuals; acquiring, for a patient, a geometric model and blood flow characteristics for part of the patient's vascular system; and executing the machine learning algorithm on the patient's geometric model and blood flow characteristics to determine, based on the predictive features, plaque information of the patient for at least one point in the patient's geometric model.

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Номер записи: 46
22-11-2022 дата публикации

Systems and methods for monitoring and updating blood flow calculations with user-specific anatomic and physiologic sensor data

Номер: US0011504019B2
Автор: Timothy A. Fonte, Leo Grady, Charles A. Taylor
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed for informing and monitoring blood flow calculations with user-specific activity data, including sensor data. One method includes receiving or accessing a user-specific anatomical model and a first set of physiological characteristics of a user; calculating a first value of a blood flow metric of the user based on the user-specific anatomical model and the first set of physiological characteristics; receiving or calculating a second set of physiological characteristics of the user by accessing or receiving sensor data of the user's blood flow and/or sensor data of the user's physiological characteristics; and calculating second value of the blood flow metric of the user based on the user-specific anatomical model and the second set of physiological characteristics of the user.

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Номер записи: 47
05-10-2021 дата публикации

Method and system for image processing to determine patient-specific blood flow characteristics

Номер: US0011135012B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 48
07-07-2020 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US0010702339B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 49
25-05-2017 дата публикации

SYSTEMS AND METHODS FOR ASSESSING ORGAN AND/OR TISSUE TRANSPLANTATION BY SIMULATING ONE OR MORE TRANSPLANT CHARACTERISTICS

Номер: US20170143427A1
Автор: Leo GRADY, Charles A. Taylor, Christopher Zarins, GRADY LEO, TAYLOR CHARLES A, ZARINS CHRISTOPHER, GRADY Leo, Taylor Charles A., Zarins Christopher
Принадлежит:

Systems and methods are disclosed for assessing organ and/or tissue transplantation by estimating blood flow through a virtual transplant model by receiving a patient-specific anatomical model of the intended transplant recipient; receiving a patient-specific anatomical model of the intended transplant donor, the model including the vasculature of the organ or tissue that is intended to be transplanted to the recipient; constructing a unified model of the connected system post transplantation, the connected system including the transplanted organ or tissue from the intended transplant donor and the vascular system of the intended transplant recipient; receiving one or more blood flow characteristics of the connected system; assessing the suitability for an actual organ or tissue transplantation using the received blood flow characteristics; and outputting the assessment into an electronic storage medium or display. 1. A computer implemented method for assessing organ or tissue transplantation by estimating blood flow through a virtual transplant model , the method comprising:receiving a patient-specific anatomical model of an intended transplant recipient, including a vasculature of the intended transplant recipient that is designated to supply blood to the transplanted organ or tissue;receiving a patient-specific anatomical model of an intended transplant donor, including a vasculature of the organ or tissue of the intended transplant donor that is designated to be transplanted to the intended transplant recipient;constructing a unified model of a connected system post transplantation, including at least some of the vasculature of the organ or tissue of the intended transplant donor and at least some of the vasculature of the intended transplant recipient designated to supply blood to the transplanted organ or tissue;estimating blood flow through the unified model of the connected system to compute one or more blood flow characteristics of the blood flow through ...

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Номер записи: 50
24-07-2014 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20140207432A1
Автор: Charles A. Taylor, TAYLOR CHARLES A, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A system for determining cardiovascular information for a patient , the system comprising:at least one computer system configured to:receive patient-specific data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of one or more coronary arteries;create a three-dimensional model representing at least the portion of the one or more coronary arteries, based on the received patient-specific data;create, based on the three-dimensional model, a blood flow model relating to a blood flow characteristic within the portion of the one or more coronary arteries, the blood flow model including one or more equations of blood flow and one or more boundary conditions of the blood flow characteristic;determine a value of the blood flow characteristic at each of a plurality of locations of the portion of the one or more coronary arteries by solving one or more equations of the blood flow model using the one or more boundary conditions; anddisplay a representation of the portion of the one or more coronary arteries, wherein the determined values of the blood flow characteristic are indicated on the display of respective locations of the one or more coronary arteries using at least one visual indicator.186. The system of claim 185 , wherein the visual indicator ...

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Номер записи: 51
10-12-2013 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US0008606530B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC, HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 52
09-10-2018 дата публикации

Systems and methods for predicting location, onset, and/or change of coronary lesions

Номер: US0010096104B2
Автор: Gilwoo Choi, Leo Grady, Charles A. Taylor, CHOI GILWOO, GRADY LEO, TAYLOR CHARLES A, Choi, Gilwoo, Grady, Leo, Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Systems and methods are disclosed for predicting the location, onset, or change of coronary lesions from factors like vessel geometry, physiology, and hemodynamics. One method includes: acquiring, for each of a plurality of individuals, a geometric model, blood flow characteristics, and plaque information for part of the individual's vascular system; training a machine learning algorithm based on the geometric models and blood flow characteristics for each of the plurality of individuals, and features predictive of the presence of plaque within the geometric models and blood flow characteristics of the plurality of individuals; acquiring, for a patient, a geometric model and blood flow characteristics for part of the patient's vascular system; and executing the machine learning algorithm on the patient's geometric model and blood flow characteristics to determine, based on the predictive features, plaque information of the patient for at least one point in the patient's geometric model.

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Номер записи: 53
04-06-2019 дата публикации

Systems and methods for assessing the severity of plaque and/or stenotic lesions using contrast distribution predictions and measurements

Номер: US0010307131B2
Автор: Charles A. Taylor, Leo Grady, Sethuraman Sankaran, Souma Sengupta, Hyun Jin Kim, Nan Xiao, TAYLOR CHARLES A, GRADY LEO, SANKARAN SETHURAMAN, SENGUPTA SOUMA, KIM HYUN JIN, XIAO NAN, Taylor, Charles A., Grady, Leo, Sankaran, Sethuraman, Sengupta, Souma, Kim, Hyun Jin, Xiao, Nan
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Systems and methods are disclosed for assessing the severity of plaque and/or stenotic lesions using contrast distribution predictions and measurements. One method includes: receiving patient-specific images of a patient's vasculature and a measured distribution of a contrast agent delivered through the patient's vasculature; associating the measured distribution of the contrast agent with a patient-specific anatomic model of the patient's vasculature; defining physiological and boundary conditions of a blood flow model of the patient's blood flow and pressure; simulating the distribution of the contrast agent through the patient-specific anatomic model; comparing the measured distribution of the contrast agent and the simulated distribution of the contrast agent through the patient-specific anatomic model to determine whether a similarity condition is satisfied; and updating the defined physiological and boundary conditions and re-simulating distribution of the contrast agent through the ...

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Номер записи: 54
26-09-2017 дата публикации

Systems and methods for predicting coronary plaque vulnerability from patient-specific anatomic image data

Номер: US0009770303B2
Автор: Gilwoo Choi, Leo Grady, Michiel Schaap, Charles A. Taylor, CHOI GILWOO, GRADY LEO, SCHAAP MICHIEL, TAYLOR CHARLES A, Choi Gilwoo, Grady Leo, Schaap Michiel, Taylor Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Systems and methods are disclosed for predicting coronary plaque vulnerability, using a computer system. One method includes acquiring anatomical image data of at least part of the patient's vascular system; performing, using a processor, one or more image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical image data; predicting, using the processor, a coronary plaque vulnerability present in the patient's vascular system, wherein predicting the coronary plaque vulnerability includes calculating an adverse plaque characteristic based on results of the one or more of image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis of the anatomical image data; and reporting, using the processor, the calculated adverse plaque characteristic.

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Номер записи: 55
17-08-2021 дата публикации

Method and system for image processing and patient-specific modeling of blood flow

Номер: US0011090118B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 56
14-03-2013 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20130066618A1
Автор: Charles A. Taylor, Timothy A. Fonte, Gilwoo Choi, Ying Bai, Christopher K. Zarins
Принадлежит: HeartFlow Inc

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 57
03-03-2016 дата публикации

SYSTEMS AND METHODS FOR DETERMINATION OF BLOOD FLOW CHARACTERISTICS AND PATHOLOGIES THROUGH MODELING OF MYOCARDIAL BLOOD SUPPLY

Номер: US20160058303A1
Автор: Leo J. GRADY, Charles A. Taylor
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving one or more vascular models associated with either the patient or with a plurality of individuals; receiving observed perfusion information associated with the patient; and estimating, using one or more computer processors, one or more blood flow characteristics or one or more pathological characteristics of the patient based on the observed perfusion information and the one or more vascular models. 1. A computer-implemented method of evaluating a patient with vascular disease , the method comprising:receiving a tissue model of the patient, wherein at least one tissue characteristic is measureable from the tissue model, the tissue characteristic including a measure of tissue viability, a tissue capacity to change blood flow, a tissue irregularity, a tissue electrical property, and/or a tissue mechanical property;receiving a vascular model defining one or more vessel pathologies at a location of vasculature supplying blood to the tissue model;determining a first tissue characteristic value of the tissue model in response to a first vessel pathology;determining a changed tissue characteristic value of the tissue model in response to a second vessel pathology;determining an effect of vessel pathology on the at least one tissue characteristic, based on a comparison of the first tissue characteristic to the changed tissue characteristic;receiving an observed tissue characteristic value associated with a patient; andestimating, using one or more computer processors, one or more patient pathological characteristics at a location in the patient's anatomy using the observed tissue characteristic value and the determined effect of the vessel pathology on the at least one tissue characteristic.2. The computer-implemented method of claim 1 , further comprising:using the observed tissue characteristic and the determined effect of vessel pathology on the at least on ...

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Номер записи: 58
23-05-2023 дата публикации

System and methods for estimation of blood flow characteristics using reduced order model and machine learning

Номер: US0011653833B2
Автор: Travis Michael Sanders, Sethuraman Sankaran, Leo Grady, David Spain, Nan Xiao, Jin Kim, Charles A. Taylor
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed for determining blood flow characteristics of a patient. One method includes: receiving, in an electronic storage medium, patient-specific image data of at least a portion of vasculature of the patient having geometric features at one or more points; generating a patient-specific reduced order model from the received image data, the patient-specific reduced order model comprising estimates of impedance values and a simplification of the geometric features at the one or more points of the vasculature of the patient; creating a feature vector comprising the estimates of impedance values and geometric features for each of the one or more points of the patient-specific reduced order model; and determining blood flow characteristics at the one or more points of the patient-specific reduced order model using a machine learning algorithm trained to predict blood flow characteristics based on the created feature vectors at the one or more points.

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Номер записи: 59
30-05-2023 дата публикации

Systems and methods for predicting location, onset, and/or change of coronary lesions

Номер: US0011663715B2
Автор: Gilwoo Choi, Leo Grady, Charles A. Taylor
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed for predicting the location, onset, or change of coronary lesions from factors like vessel geometry, physiology, and hemodynamics. One method includes: acquiring, for each of a plurality of individuals, a geometric model, blood flow characteristics, and plaque information for part of the individual's vascular system; training a machine learning algorithm based on the geometric models and blood flow characteristics for each of the plurality of individuals, and features predictive of the presence of plaque within the geometric models and blood flow characteristics of the plurality of individuals; acquiring, for a patient, a geometric model and blood flow characteristics for part of the patient's vascular system; and executing the machine learning algorithm on the patient's geometric model and blood flow characteristics to determine, based on the predictive features, plaque information of the patient for at least one point in the patient's geometric model.

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Номер записи: 60
27-05-2014 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US0008734357B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc., TAYLOR CHARLES A, HEARTFLOW INC, TAYLOR CHARLES A., HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 61
10-08-2021 дата публикации

Method and system for processing images to determine blood flow characteristics

Номер: US0011087884B2
Автор: Sethuraman Sankaran, Leo J. Grady, Charles A. Taylor, SANKARAN SETHURAMAN, GRADY LEO J, TAYLOR CHARLES A, Sankaran, Sethuraman, Grady, Leo J., Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Embodiments include systems and methods for determining cardiovascular information for a patient. A method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of the patient's vasculature based on the patient-specific data; and creating a computational model of a blood flow characteristic based on the anatomic model. The method also includes identifying one or more of an uncertain parameter, an uncertain clinical variable, and an uncertain geometry; modifying a probability model based on one or more of the identified uncertain parameter, uncertain clinical variable, or uncertain geometry; determining a blood flow characteristic within the patient's vasculature based on the anatomic model and the computational model of the blood flow characteristic of the patient's vasculature; and calculating, based on the probability model and the determined blood flow characteristic, a sensitivity of the ...

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Номер записи: 62
19-08-2014 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US0008812246B2
Автор: Charles A. Taylor
Принадлежит: HeartFlow, Inc.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 63
21-05-2024 дата публикации

Systems and methods for vascular diagnosis using blood flow magnitude and/or direction

Номер: US0011986280B2
Автор: Leo J. Grady, Charles A. Taylor
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed for diagnosing and treatment planning for vascular steal syndromes and retrograde flow, One method includes receiving a reference blood flow direction at a location in a reference vasculature; determining a patient-related brood flow direction at a location in a patient's vasculature corresponding to the location in the reference vasculature; determining a difference in direction, between the reference blood flow direction of the reference vasculature and the patient-related blood flow direction of the patient's vasculature; and generating a representation of the location in the patient's vasculature associated with the difference in direction between the reference blood flow direction and the patient-related blood flow direction, or generating a treatment recommendation for the patient's vasculature based on the difference in direction between the reference blood flow direction and the patient-related blood flow direction.

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Номер записи: 64
28-04-2016 дата публикации

METHOD AND SYSTEM FOR IMAGE PROCESSING TO DETERMINE PATIENT-SPECIFIC BLOOD FLOW CHARACTERISTICS

Номер: US20160117815A1
Автор: Charles A. Taylor
Принадлежит: HeartFlow, Inc.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A system for image processing to determine cardiovascular information for a patient , the system comprising: ["receive patient-specific data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of a plurality of coronary arteries emanating from the patient's aorta;", 'create a three-dimensional geometric model representing the anatomical structure using the patient-specific data;', 'generate a one-dimensional blood flow model defining blood flow through the anatomical structure of the patient using the three-dimensional geometric model;', 'generate a boundary condition model using the three-dimensional geometric model; and', 'determine at least one blood flow characteristic within the anatomical structure using the boundary condition model and the one-dimensional blood flow model, wherein the blood flow characteristic is a ratio of pressures at two or more locations within the anatomical structure., 'at least one computer system configured to186. The system of claim 185 , wherein the patient-specific data corresponds to the patient being under a physiological condition of rest.187. The system of claim 185 , wherein the at least one computer system configured to generate a boundary condition model is further configured to:determine, based on the three ...

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Номер записи: 65
14-06-2012 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20120150516A1
Автор: Charles A. Taylor, Timothy A. Fonte, Gilwoo Choi, Ying Bai, Christopher K. Zarins, TAYLOR CHARLES A, FONTE TIMOTHY A, CHOI GILWOO, BAI YING, ZARINS CHRISTOPHER K, TAYLOR CHARLES A., FONTE TIMOTHY A., ZARINS CHRISTOPHER K.
Принадлежит: HeartFlow, Inc.

Embodiments include a system for determining patient-specific cardiovascular information. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of an anatomical structure of the patient and create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data. The at least one computer system may be further configured to determine a total resistance associated with a total flow through the portion of the anatomical structure of the patient, and determine information regarding a blood flow characteristic within the anatomical structure of the patient based on the three-dimensional model, a physics-based model relating to the anatomical structure of the patient, and the determined total resistance. 1. A system for determining patient-specific cardiovascular information , the system comprising: receive patient-specific data regarding a geometry of an anatomical structure of the patient;', 'create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data;', 'determine a total resistance associated with a total flow through the portion of the anatomical structure of the patient; and', 'determine information regarding a blood flow characteristic within the anatomical structure of the patient based on the three-dimensional model, a physics-based model relating to the anatomical structure of the patient, and the determined total resistance., 'at least one computer system configured to2. The system of claim 1 , whereinthe anatomical structure of the patient includes at least a portion of an aorta and at least a portion of a plurality of coronary arteries emanating from the portion of the aorta; andthe total resistance is associated with a total flow through the plurality of coronary arteries.3. The system of claim 2 , wherein the at least one computer system is ...

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Номер записи: 66
25-09-2018 дата публикации

Method and system for image processing to determine patient-specific blood flow characteristics

Номер: US0010080614B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 67
30-07-2013 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US0008496594B2
Автор: Charles A. Taylor, Timothy A. Fonte, TAYLOR CHARLES A, FONTE TIMOTHY A, TAYLOR CHARLES A., FONTE TIMOTHY A.
Принадлежит: Heartflow, Inc., TAYLOR CHARLES A, FONTE TIMOTHY A, HEARTFLOW INC, TAYLOR CHARLES A., FONTE TIMOTHY A., HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 68
24-03-2020 дата публикации

Systems and methods for predicting tissue viability deficits from physiological, anatomical, and patient characteristics

Номер: US0010595728B2
Автор: Gilwoo Choi, Michiel Schaap, Charles A. Taylor, Leo Grady, CHOI GILWOO, SCHAAP MICHIEL, TAYLOR CHARLES A, GRADY LEO, Choi, Gilwoo, Schaap, Michiel, Taylor, Charles A., Grady, Leo
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Systems and methods are disclosed for using patient-specific anatomical models and physiological parameters to predict viability of a target tissue or vessel to guide diagnosis or treatment of cardiovascular disease. One method includes: receiving a patient-specific vessel model and a patient-specific tissue model of a patient anatomy; receiving one or more patient-specific physiological parameters (e.g. blood flow, anatomical characteristics, etc.) for one or more physiological states; estimating a viability characteristic of the patient-specific tissue or vessel model (e.g., via a trained machine learning algorithm), using the patient-specific physiological parameters; and outputting the viability characteristic to an electronic storage medium or display.

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Номер записи: 69
28-10-2021 дата публикации

SYSTEMS AND METHODS FOR IMAGE PROCESSING TO DETERMINE BLOOD FLOW

Номер: US20210335497A1
Автор: Sethuraman Sankaran, Leo J. Grady, Charles A. Taylor
Принадлежит: HeartFlow, Inc.

Embodiments include systems and methods for determining cardiovascular information for a patient. A method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of the patient's vasculature based on the patient-specific data; and creating a computational model of a blood flow characteristic based on the anatomic model. The method also includes identifying one or more of an uncertain parameter, an uncertain clinical variable, and an uncertain geometry; modifying a probability model based on one or more of the identified uncertain parameter, uncertain clinical variable, or uncertain geometry; determining a blood flow characteristic within the patient's vasculature based on the anatomic model and the computational model of the blood flow characteristic of the patient's vasculature; and calculating, based on the probability model and the determined blood flow characteristic, a sensitivity of the ...

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Номер записи: 70
06-12-2022 дата публикации

Systems and methods for identifying and modeling unresolved vessels in image-based patient-specific hemodynamic models

Номер: US0011521755B2
Автор: Charles A. Taylor, Hyun Jin Kim, Leo Grady, Rhea Tombropoulos, Gilwoo Choi, Nan Xiao, David Spain
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed for identifying and modeling unresolved vessels, and the effects thereof, in image-based patient-specific hemodynamic models. One method includes: receiving, in an electronic storage medium, one or more patient-specific anatomical models representing at least a vessel of a patient; determining, using a processor, the values and characteristics of one or more patient-specific morphometric features in the one or more patient-specific anatomical models; modifying the patient-specific anatomical model using the determined patient-specific morphometric features; and outputting, one or more of, a modified patient-specific anatomical model or a patient-specific morphometric feature to an electronic storage medium or display.

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Номер записи: 71
10-10-2017 дата публикации

Systems and methods for estimating hemodynamic forces acting on plaque and monitoring patient risk

Номер: US0009785748B2
Автор: Bon-Kwon Koo, Gilwoo Choi, Hyun Jin Kim, Charles A. Taylor, KOO BON-KWON, CHOI GILWOO, KIM HYUN JIN, TAYLOR CHARLES A, Koo Bon-Kwon, Choi Gilwoo, Kim Hyun Jin, Taylor Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Computer-implemented methods are disclosed for estimating values of hemodynamic forces acting on plaque or lesions. One method includes: receiving one or more patient-specific parameters of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion; constructing a patient-specific geometric model of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion, using the received one or more patient-specific parameters; estimating, using one or more processors, the values of hemodynamic forces at one or more points on the patient-specific geometric model, using the patient-specific parameters and geometric model by measuring, deriving, or obtaining one or more of a pressure gradient and a radius gradient; and outputting the estimated values of hemodynamic forces to an electronic storage medium. Systems and computer readable media for executing these methods are also disclosed.

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Номер записи: 72
20-09-2016 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US0009449147B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 73
15-08-2013 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20130211728A1
Автор: Charles A. Taylor, Timothy A. Fonte, Gilwoo Choi, Ying Bai, Christopher K. Zarins
Принадлежит: HeartFlow, Inc.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A system for determining patient-specific cardiovascular information , the system comprising: receive patient-specific data regarding a geometry of an anatomical structure of the patient;', 'create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data;', "determine, for each of a plurality of portions of the anatomical structure of the patient, a resistance associated with flow through each of the plurality of portions, wherein the resistance is determined based on resistance values associated with other patients' patient-specific data; and", 'determine information regarding a blood flow characteristic within the anatomical structure of the patient based on the three-dimensional model and a second model generated based on the determined resistances., 'at least one computer system configured to186. The system of claim 185 , wherein the at least one computer system is configured to determine each resistance based on an empirical model based on a library of resistance values stored in relation to other patients' patient-specific data.187. The system of claim 185 , wherein the at least one computer system is further configured to determine each resistance based on resistance values associated with patient-specific data claim 185 , by: ...

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Номер записи: 74
16-03-2021 дата публикации

System and methods for estimation of blood flow characteristics using reduced order model and machine learning

Номер: US0010945606B2
Автор: Travis Michael Sanders, Sethuraman Sankaran, Leo Grady, David Spain, Nan Xiao, Jin Kim, Charles A. Taylor, SANDERS TRAVIS MICHAEL, SANKARAN SETHURAMAN, GRADY LEO, SPAIN DAVID, XIAO NAN, KIM JIN, TAYLOR CHARLES A, Sanders, Travis Michael, Sankaran, Sethuraman, Grady, Leo, Spain, David, Xiao, Nan, Kim, Jin, Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Systems and methods are disclosed for determining blood flow characteristics of a patient. One method includes: receiving, in an electronic storage medium, patient-specific image data of at least a portion of vasculature of the patient having geometric features at one or more points; generating a patient-specific reduced order model from the received image data, the patient-specific reduced order model comprising estimates of impedance values and a simplification of the geometric features at the one or more points of the vasculature of the patient; creating a feature vector comprising the estimates of impedance values and geometric features for each of the one or more points of the patient-specific reduced order model; and determining blood flow characteristics at the one or more points of the patient-specific reduced order model using a machine learning algorithm trained to predict blood flow characteristics based on the created feature vectors at the one or more points.

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Номер записи: 75
13-08-2019 дата публикации

Method and system for image processing and patient-specific modeling of blood flow

Номер: US0010376317B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 76
10-09-2019 дата публикации

Systems and methods for determining and visualizing a functional relationship between a vascular network and perfused tissue

Номер: US0010405925B2
Автор: Clara Jaquet, Michiel Schaap, Ying Bai, Leo Grady, Charles A. Taylor, JAQUET CLARA, SCHAAP MICHIEL, BAI YING, GRADY LEO, TAYLOR CHARLES A, Jaquet, Clara, Schaap, Michiel, Bai, Ying, Grady, Leo, Taylor, Charles A.
Принадлежит: HEARTFLOW, INC., HEARTFLOW INC, HeartFlow, Inc.

Systems and methods are disclosed for creating an interactive tool for determining and displaying a functional relationship between a vascular network and an associated perfused tissue. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model, including a tissue region associated with the at least one vessel of the patient; receiving a selected area of the vascular model or a selected area of the tissue model; and generating a display of a region of the tissue model corresponding to the selected area of the vascular model or a display of a portion of the vascular model corresponding to the selected area of the tissue model, respectively.

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Номер записи: 77
26-03-2015 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20150088478A1
Автор: Charles A. Taylor, TAYLOR CHARLES A, TAYLOR CHARLES A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A system for evaluating cardiovascular treatment options for a patient , the system comprising: ["create a three-dimensional model representing at least a portion of the patient's heart or vasculature based on patient-specific data regarding a geometry of the patients heart or vasculature;", "for each of a plurality of treatment options for treating at least a portion of the patient's heart, modify at least one of the three-dimensional model and a reduced order model based on the three-dimensional model;", 'determine, for each of the plurality of treatment options, a value of a blood flow characteristic, by solving at least one of the modified three-dimensional model and the modified reduced order model; and', "identify one of the plurality of treatment options that solves a function of at least one of: the determined blood flow characteristics of the patient's heart or vasculature, and one or more costs of each of the plurality of treatment options."], 'at least one computer system configured to186185. The system of , wherein the computer system is configured to modify , for each of the plurality of treatment options , the three-dimensional model using a geometric modification technique.187185. The system of , wherein the computer system is configured to modify , for each of the plurality of treatment options , ...

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Номер записи: 78
12-03-2020 дата публикации

SYSTEMS AND METHODS FOR ASSESSING ORGAN AND/OR TISSUE TRANSPLANTATION BY SIMULATING ONE OR MORE TRANSPLANT CHARACTERISTICS

Номер: US20200078094A1
Автор: Leo Grady, Charles A. Taylor, Christopher Zarins, GRADY LEO, TAYLOR CHARLES A, ZARINS CHRISTOPHER, Grady, Leo, Taylor, Charles A., Zarins, Christopher
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed for assessing organ and/or tissue transplantation by estimating blood flow through a virtual transplant model by receiving a patient-specific anatomical model of the intended transplant recipient; receiving a patient-specific anatomical model of the intended transplant donor, the model including the vasculature of the organ or tissue that is intended to be transplanted to the recipient; constructing a unified model of the connected system post transplantation, the connected system including the transplanted organ or tissue from the intended transplant donor and the vascular system of the intended transplant recipient; receiving one or more blood flow characteristics of the connected system; assessing the suitability for an actual organ or tissue transplantation using the received blood flow characteristics; and outputting the assessment into an electronic storage medium or display. 120-. (canceled)21. A computer implemented method for assessing organ or tissue transplantation by estimating blood flow through a virtual transplant model , the method comprising:receiving a donor anatomical model, including a representation of a vasculature of an intended transplant donor;receiving a recipient anatomical model, including a representation of a vasculature of an intended transplant recipient;constructing a geometric model comprising a portion of the recipient anatomical model and a portion of the donor anatomical model;estimating blood flow through the geometric model to compute one or more blood flow characteristics;evaluating the planned transplantation using the one or more computed blood flow characteristics; andoutputting the evaluation into an electronic storage medium or display.22. The computer implemented method of claim 21 , further comprising:determining one or more pre-transplantation blood flow characteristics using the recipient anatomical model; andevaluating the planned transplantation using a comparison of the computed ...

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Номер записи: 79
16-02-2012 дата публикации

Method and System for Patient-Specific Modeling of Blood Flow

Номер: US20120041739A1
Автор: Charles A. Taylor, TAYLOR CHARLES A, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 80
30-05-2023 дата публикации

Systems and methods for diagnosis and assessment of cardiovascular disease by comparing arterial supply capacity to end-organ demand

Номер: US0011660143B2
Автор: Charles A. Taylor, Hyun Jin Kim, Sophie Khem, Sethuraman Sankaran, David Spain, Nan Xiao
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed for to determining a blood supply and blood demand. One method includes receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium; determining a coronary blood supply based on the patient-specific model; determining at least a portion of the myocardium corresponding to the coronary artery; determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; and determining a relationship between the coronary blood supply and the myocardial blood demand.

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Номер записи: 81
29-12-2015 дата публикации

Systems and methods for predicting coronary plaque vulnerability from patient-specific anatomic image data

Номер: US0009220418B2
Автор: Gilwoo Choi, Leo Grady, Michiel Schaap, Charles A. Taylor, CHOI GILWOO, GRADY LEO, SCHAAP MICHIEL, TAYLOR CHARLES A, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC, HEARTFLOW, INC.

Systems and methods are disclosed for predicting coronary plaque vulnerability, using a computer system. One method includes acquiring anatomical image data of at least part of the patient's vascular system; performing, using a processor, one or more image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical image data; predicting, using the processor, a coronary plaque vulnerability present in the patient's vascular system, wherein predicting the coronary plaque vulnerability includes calculating an adverse plaque characteristic based on results of the one or more of image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis of the anatomical image data; and reporting, using the processor, the calculated adverse plaque characteristic.

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Номер записи: 82
02-01-2024 дата публикации

Systems and methods for processing electronic images to predict lesions

Номер: US0011861831B2
Автор: Gilwoo Choi, Leo Grady, Charles A. Taylor
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed for predicting the location, onset, or change of coronary lesions from factors like vessel geometry, physiology, and hemodynamics. One method includes: acquiring, for each of a plurality of individuals, a geometric model, blood flow characteristics, and plaque information for part of the individual's vascular system; training a machine learning algorithm based on the geometric models and blood flow characteristics for each of the plurality of individuals, and features predictive of the presence of plaque within the geometric models and blood flow characteristics of the plurality of individuals; acquiring, for a patient, a geometric model and blood flow characteristics for part of the patient's vascular system; and executing the machine learning algorithm on the patient's geometric model and blood flow characteristics to determine, based on the predictive features, plaque information of the patient for at least one point in the patient's geometric model.

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Номер записи: 83
31-12-2019 дата публикации

Methods and systems for predicting sensitivity of blood flow calculations to changes in anatomical geometry

Номер: US0010522254B2
Автор: Sethuraman Sankaran, Leo Grady, Charles A. Taylor, SANKARAN SETHURAMAN, GRADY LEO, TAYLOR CHARLES A, Sankaran, Sethuraman, Grady, Leo, Taylor, Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Embodiments include methods and systems for determining a sensitivity of a patient's blood flow characteristic to anatomical or geometrical uncertainty. For each of one or more of individuals, a sensitivity of a blood flow characteristic may be obtained for one or more uncertain parameters. An algorithm may be trained based on the sensitivities of the blood flow characteristic and one or more of the uncertain parameters for each of the plurality of individuals. A geometric model, a blood flow characteristic, and one or more of the uncertain parameters of at least part of the patient's vascular system may be obtained for a patient. The sensitivity of the patient's blood flow characteristic to one or more of the uncertain parameters may be calculated by executing the algorithm on the blood flow characteristic of at least part of the patient's vascular system, and one or more of the uncertain parameters.

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Номер записи: 84
31-12-2015 дата публикации

SYSTEMS AND METHODS FOR DETERMINING AND VISUALIZING PERFUSION OF MYOCARDIAL MUSCLE

Номер: US20150379230A1
Автор: Charles A. Taylor
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 85
06-06-2017 дата публикации

Method and system for quantifying limitations in coronary artery blood flow during physical activity in patients with coronary artery disease

Номер: US0009668700B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Embodiments include a system for determining cardiovascular information for a patient with coronary artery disease. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart and create a model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create, for a given level of physical activity, a physics-based model of blood flow through the patient's heart simulated during a selected level of physical activity; determine and normalize one or more values of at least one blood flow characteristic within the patient's heart during the simulated level of physical activity; and compare the one or more normalized values of the at least one blood flow characteristic to a threshold to determine whether the level of physical activity exceeds an acceptable level of risk.

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Номер записи: 86
20-11-2012 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US0008315813B2
Автор: Charles A. Taylor, Timothy A. Fonte, Gilwoo Choi, TAYLOR CHARLES A, FONTE TIMOTHY A, CHOI GILWOO, TAYLOR CHARLES A., FONTE TIMOTHY A.
Принадлежит: HeartFlow, Inc., TAYLOR CHARLES A, FONTE TIMOTHY A, CHOI GILWOO, HEARTFLOW INC, TAYLOR CHARLES A., FONTE TIMOTHY A., HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 87
29-12-2015 дата публикации

Systems and methods for predicting coronary plaque vulnerability from patient-specific anatomic image data

Номер: US0009220419B2
Автор: Gilwoo Choi, Leo J. Grady, Michiel Schaap, Charles A. Taylor, CHOI GILWOO, GRADY LEO J, SCHAAP MICHIEL, TAYLOR CHARLES A, GRADY LEO J., TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC, HEARTFLOW, INC.

Systems and methods are disclosed for predicting coronary plaque vulnerability, using a computer system. One method includes acquiring anatomical image data of at least part of the patient's vascular system; performing, using a processor, one or more image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical image data; predicting, using the processor, a coronary plaque vulnerability present in the patient's vascular system, wherein predicting the coronary plaque vulnerability includes calculating an adverse plaque characteristic based on results of the one or more of image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis of the anatomical image data; and reporting, using the processor, the calculated adverse plaque characteristic.

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Номер записи: 88
18-07-2017 дата публикации

Method and system for image processing to determine patient-specific blood flow characteristics

Номер: US0009706925B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor Charles A.
Принадлежит: HEARTFLOW, INC., HEARTFLOW INC, HeartFlow, Inc.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 89
02-01-2024 дата публикации

Systems and methods for embolism prediction using embolus source and destination probabilities

Номер: US0011862342B2
Автор: Leo J. Grady, Gilwoo Choi, Charles A. Taylor, Christopher K. Zarins
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed for determining a patient risk assessment or treatment plan based on emboli dislodgement and destination. One method includes receiving a patient-specific anatomic model generated from patient-specific imaging of at least a portion of a patient's vasculature; determining or receiving a location of interest in the patient-specific anatomic model of the patient's vasculature; using a computing processor for calculating blood flow through the patient-specific anatomic model to determine blood flow characteristics through at least the portion of the patient's vasculature of the patient-specific anatomic model downstream from the location of interest; and using a computing processor for particle tracking through the simulated blood flow to determine a destination probability of an embolus originating from the location of interest in the patient-specific anatomic model, based on the determined blood flow characteristics.

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Номер записи: 90
29-08-2017 дата публикации

Method and system for image processing to determine patient-specific blood flow characteristics

Номер: US0009743835B2
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor Charles A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 91
23-09-2010 дата публикации

Patient-specific hemodynamics of the cardio vascular system

Номер: US20100241404A1
Автор: Charles A. Taylor, Hyun Jin Kim, Jessica S. Coogan, TAYLOR CHARLES A, KIM HYUN JIN, COOGAN JESSICA S, TAYLOR CHARLES A., COOGAN JESSICA S.
Принадлежит:

A noninvasive patient-specific method is provided to aid in the analysis, diagnosis, prediction or treatment of hemodynamics of the cardiovascular system of a patient. Coronary blood flow and pressure can be predicted using a 3-D patient image-based model that is implicitly coupled with a model of at least a portion of the remaining cardiovascular system. The 3-D patient image-based model includes at least a portion of the thoracic aorta and epicardial coronaries of the patient. The shape of one or more velocity profiles at the interface of the models is enforced to control complex flow features of recirculating or retrograde flow thereby minimizing model instabilities and resulting in patient-specific predictions of coronary flow rate and pressure. The invention allows for patient-specific predictions of the effect of different or varying physiological states and hemodynamic benefits of coronary medical interventions, percutaneous coronary interventions and surgical therapies.

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Номер записи: 92
31-12-2019 дата публикации

System and method for diagnosis and assessment of cardiovascular disease by comparing arterial supply capacity to end-organ demand

Номер: US0010517678B2
Автор: Charles A. Taylor, Hyun Jin Kim, Sophie Khem, Sethuraman Sankaran, David Spain, Nan Xiao, TAYLOR CHARLES A, KIM HYUN JIN, KHEM SOPHIE, SANKARAN SETHURAMAN, SPAIN DAVID, XIAO NAN, Taylor, Charles A., Kim, Hyun Jin, Khem, Sophie, Sankaran, Sethuraman, Spain, David, Xiao, Nan
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Systems and methods are disclosed for to determining a blood supply and blood demand. One method includes receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium; determining a coronary blood supply based on the patient-specific model; determining at least a portion of the myocardium corresponding to the coronary artery; determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; and determining a relationship between the coronary blood supply and the myocardial blood demand.

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Номер записи: 93
14-06-2022 дата публикации

Systems and methods for assessing the severity of plaque and/or stenotic lesions using contrast distribution predictions and measurements

Номер: US0011357469B2
Автор: Charles A. Taylor, Leo Grady, Sethuraman Sankaran, Souma Sengupta, Hyun Jin Kim, Nan Xiao
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed for assessing the severity of plaque and/or stenotic lesions using contrast distribution predictions and measurements. One method includes: receiving patient-specific images of a patient's vasculature and a measured distribution of a contrast agent delivered through the patient's vasculature; associating the measured distribution of the contrast agent with a patient-specific anatomic model of the patients vasculature; defining physiological and boundary conditions of a blood flow model of the patient's blood flow and pressure; simulating the distribution of the contrast agent through the patient-specific anatomic model; comparing the measured distribution of the contrast agent and the simulated distribution of the contrast agent through the patient-specific anatomic model to determine whether a similarity condition is satisfied; and updating the defined physiological and boundary conditions and re-simulating distribution of the contrast agent through the ...

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Номер записи: 94
30-11-2017 дата публикации

METHOD AND SYSTEM FOR IMAGE PROCESSING TO DETERMINE BLOOD FLOW

Номер: US20170340392A1
Автор: Charles A. Taylor
Принадлежит: HeartFlow, Inc.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 95
26-02-2013 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US0008386188B2
Автор: Charles A. Taylor, Timothy A. Fonte, Ying Bai, TAYLOR CHARLES A, FONTE TIMOTHY A, BAI YING, TAYLOR CHARLES A., FONTE TIMOTHY A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC, TAYLOR CHARLES A, FONTE TIMOTHY A, BAI YING, HEARTFLOW, INC., TAYLOR CHARLES A., FONTE TIMOTHY A.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 96
26-12-2023 дата публикации

Systems and methods for anatomical modeling using information obtained from a medical procedure

Номер: US0011854704B2
Автор: Leo Grady, Charles A. Taylor, Campbell Rogers, Christopher K. Zarins, Gilwoo Choi
Принадлежит: HeartFlow, Inc.

Systems and methods are disclosed herein for anatomical modeling using information obtained during a medical procedure, whereby an initial anatomical model is generated or obtained, a correspondence is determined between the initial model and additional data and/or measurements from an invasive or noninvasive procedure, and, if a discrepancy is found between the initial model and the additional data, the anatomical model is updated to incorporate the additional data and reduce the discrepancy.

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Номер записи: 97
26-05-2015 дата публикации

Systems and methods for identifying personalized vascular implants from patient-specific anatomic data

Номер: US0009043190B2
Автор: Leo Grady, Charles A. Taylor, Gilwoo Choi, Campbell Rogers, GRADY LEO, TAYLOR CHARLES A, CHOI GILWOO, ROGERS CAMPBELL, TAYLOR CHARLES A.
Принадлежит: HeartFlow, Inc., HEARTFLOW INC, HEARTFLOW, INC.

Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising acquiring an anatomical model of at least part of the patient's vascular system; performing, using a processor, one or more of geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical model; and identifying, using the processor, a personalized cardiovascular device for the patient, based on results of one or more of the geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis of anatomical model.

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Номер записи: 98
20-07-2017 дата публикации

METHOD AND SYSTEM FOR IMAGE PROCESSING TO DETERMINE BLOOD FLOW

Номер: US20170202621A1
Автор: Charles A. Taylor, TAYLOR CHARLES A, Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 99
13-04-2021 дата публикации

System and method for diagnosis and assessment of cardiovascular disease by comparing arterial supply capacity to end-organ demand

Номер: US0010973583B2
Автор: Charles A. Taylor, Hyun Jin Kim, Sophie Khem, Sethuraman Sankaran, David Spain, Nan Xiao, TAYLOR CHARLES A, KIM HYUN JIN, KHEM SOPHIE, SANKARAN SETHURAMAN, SPAIN DAVID, XIAO NAN, Taylor, Charles A., Kim, Hyun Jin, Khem, Sophie, Sankaran, Sethuraman, Spain, David, Xiao, Nan
Принадлежит: HeartFlow, Inc., HEARTFLOW INC

Systems and methods are disclosed for to determining a blood supply and blood demand. One method includes receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium; determining a coronary blood supply based on the patient-specific model; determining at least a portion of the myocardium corresponding to the coronary artery; determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; and determining a relationship between the coronary blood supply and the myocardial blood demand.

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Номер записи: 100
16-02-2012 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20120041318A1
Автор: Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 140.-. (canceled)41. A system for planning treatment for a patient , the system comprising: receive patient-specific data regarding a geometry of an anatomical structure of the patient;', 'create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data;', 'determine first information regarding a blood flow characteristic within the anatomical structure of the patient based on the three-dimensional model and information regarding a physiological condition of the patient;', 'modify the physiological condition of the patient; and', 'determine second information regarding the blood flow characteristic within the anatomical structure of the patient based on the modified physiological condition of the patient., 'at least one computer system configured to42. The system of claim 41 , wherein the at least one computer system is further configured to modify the physiological condition of the patient based on input received from a user claim 41 , the input including a selection of a plan of treatment for the patient.43. The system of claim 42 , wherein:the selected plan of treatment is associated with a change in at least one of a cardiac output, a level of exercise, a level of hyperemia, or a medication for the patient; andthe at least one computer system is further ...

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Номер записи: 101
16-02-2012 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20120041319A1
Автор: Fonte Timothy A., Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 160.-. (canceled)61. A system for determining patient-specific cardiovascular information , the system comprising: receive patient-specific data regarding a geometry of an anatomical structure of the patient;', 'create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data;', 'determine a total resistance associated with a total flow through the portion of the anatomical structure of the patient; and', 'determine information regarding a blood flow characteristic within the anatomical structure of the patient based on the three-dimensional model, a physics-based model relating to the anatomical structure of the patient, and the determined total resistance., 'at least one computer system configured to62. The system of claim 61 , whereinthe anatomical structure of the patient includes at least a portion of an aorta and at least a portion of a plurality of coronary arteries emanating from the portion of the aorta; andthe total resistance is associated with a total outflow through the plurality of coronary arteries.63. The system of claim 62 , wherein the at least one computer system is further configured to:determine an individual resistance for each of the plurality of coronary arteries based on the determined total resistance; anddetermine the information ...

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Номер записи: 102
16-02-2012 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20120041320A1
Автор: Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 180-. (canceled)81. A system for providing patient-specific cardiovascular information using a web site , the system comprising: allow a remote user to access a web site;', 'receive patient-specific data regarding at least a portion of a geometry of an anatomical structure of the patient;', 'create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data;', 'determine information regarding a blood flow characteristic within the anatomical structure of the patient based on the three-dimensional model and a physiological condition of the patient; and', 'communicate display information regarding a first three-dimensional simulation of at least the portion of the anatomical structure of the patient to the remote user using the web site, the three-dimensional simulation including the determined information regarding the blood flow characteristic., 'at least one computer system configured to82. The system of claim 81 , wherein the at least one computer system is further configured to:receive, via the web site, input from the remote user selecting a plan of treatment for the patient.83. The system of claim 82 , wherein the at least one computer system is further configured to:modify at least one of the three-dimensional model or the physiological condition of the ...

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Номер записи: 103
16-02-2012 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20120041321A1
Автор: Choi Gilwoo, Fonte Timothy A., Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1100.-. (canceled)101. A system for determining patient-specific time-varying cardiovascular information , the system comprising: receive time-varying patient-specific data regarding a geometry of at least a portion of an anatomical structure of the patient at different times;', 'create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data; and', 'determine information regarding a change in a blood flow characteristic over time within the anatomical structure of the patient based on the three-dimensional model and a physics-based model relating to the anatomical structure of the patient., 'at least one computer system configured to102. The system of claim 101 , wherein the time-varying patient-specific data relates to the geometry of the anatomical structure of the patient at different times.103. The system of claim 101 , wherein the patient-specific data includes imaging data at different times over a cardiac cycle.104. The system of claim 101 , wherein:the anatomical structure of the patient includes at least a portion of a plurality of connected arteries in the patient; andthe patient-specific data includes information regarding changes in vessel shape of the plurality of arteries.105. The system of claim 104 , wherein the plurality of arteries are ...

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Номер записи: 104
16-02-2012 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20120041322A1
Автор: Choi Gilwoo, Fonte Timothy A., Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1120.-. (canceled)121. A system for determining cardiovascular information for a patient , the system comprising: receive patient-specific data regarding a geometry and at least one material property of at least a portion of an anatomical structure of the patient, the anatomical structure including at least a portion of a blood vessel;', 'create a three-dimensional model representing the anatomical structure of the patient based on the patient-specific data;', 'determine information regarding a blood flow characteristic within the anatomical structure of the patient based on the three-dimensional model and a physiological condition of the patient; and', 'identify a location of a plaque within the blood vessel., 'at least one computer system configured to122. The system of claim 121 , wherein the at least one computer system is further configured to determine at least one of a stress claim 121 , a pressure claim 121 , a force claim 121 , or a strain on the plaque.123. The system of claim 121 , wherein the at least one computer system is further configured to assess a vulnerability of the plaque to rupture.124. The system of claim 123 , wherein the at least one computer system is further configured to assess the vulnerability of the plaque to rupture based on a ratio of a stress on the plaque over a strength of the plaque.125. The system ...

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Номер записи: 105
16-02-2012 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20120041323A1
Автор: Bai Ying, Fonte Timothy A., Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1140.-. (canceled)141. A system for determining cardiovascular information for a patient , the system comprising: receive patient-specific data regarding a geometry of at least a portion of an anatomical structure of the patient, the anatomical structure including at least a portion of a plurality of arteries and tissue connected to at least a portion of the plurality of arteries;', 'create a three-dimensional model representing the anatomical structure of the patient based on the patient-specific data;', 'divide at least a portion of the three-dimensional model representing the tissue into segments; and', 'determine information regarding a blood flow characteristic associated with at least one of the segments based on the three-dimensional model and a physiological condition of the patient., 'at least one computer system configured to142. The system of claim 141 , wherein the blood flow characteristic includes blood flow into the at least one segment.143. The system of claim 141 , wherein:the at least one computer system is further configured to subdivide at least one of the segments into subsegments; andthe blood flow characteristic includes blood flow into at least one of the subsegments.144. The system of claim 141 , wherein the at least one computer system is further configured to subdivide the segments until a desired resolution ...

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Номер записи: 106
01-03-2012 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20120053919A1
Автор: Taylor Charles A.
Принадлежит:

Embodiments include a system for providing patient-specific cardiovascular information using a web site. The system may include at least one computer system configured to allow a remote user to access a web site, receive patient-specific data regarding at least a portion of a geometry of an anatomical structure of the patient, and create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data. The at least one computer system may be further configured to determine information regarding a blood flow characteristic within the anatomical structure of the patient based on the three-dimensional model and a physiological condition of the patient, and communicate display information regarding a first three-dimensional simulation of at least the portion of the anatomical structure of the patient to the remote user using the web site. The three-dimensional simulation may include the determined information. 1. A system for providing patient-specific cardiovascular information using a web site , the system comprising: allow a remote user to access a web site;', 'receive patient-specific data regarding at least a portion of a geometry of an anatomical structure of the patient;', 'create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data;', 'determine information regarding a blood flow characteristic within the anatomical structure of the patient based on the three-dimensional model and a physiological condition of the patient; and', 'communicate display information regarding a first three-dimensional simulation of at least the portion of the anatomical structure of the patient to the remote user using the web site, the three-dimensional simulation including the determined information regarding the blood flow characteristic., 'at least one computer system configured to2. The system of claim 1 , wherein the at least ...

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Номер записи: 107
01-03-2012 дата публикации

Method and System For Patient-Specific Modeling of Blood Flow

Номер: US20120053921A1
Автор: Charles A. Taylor
Принадлежит: HeartFlow Inc

Embodiments include a system for planning treatment for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of an anatomical structure of the patient, create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data, and determine a first fractional flow reserve within the anatomical structure of the patient based on the three-dimensional model and information regarding a physiological condition of the patient. The at least one computer system may be further configured to receive input from a user regarding a plan of treatment, modify the physiological condition of the patient based on the received input, and determine a second fractional flow reserve within the anatomical structure of the patient based on the modified physiological condition of the patient.

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Номер записи: 108
08-03-2012 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20120059246A1
Автор: Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of at least a portion of an anatomical structure of the patient. The portion of the anatomical structure may include at least a portion of the patient's aorta and at least a portion of a plurality of coronary arteries emanating from the portion of the aorta. The at least one computer system may also be configured to create a three-dimensional model representing the portion of the anatomical structure based on the patient-specific data, create a physics-based model relating to a blood flow characteristic within the portion of the anatomical structure, and determine a fractional flow reserve within the portion of the anatomical structure based on the three-dimensional model and the physics-based model. 1. A system for determining cardiovascular information for a patient , the system comprising: ["receive patient-specific data regarding a geometry of at least a portion of an anatomical structure of the patient, the portion of the anatomical structure including at least a portion of the patient's aorta and at least a portion of a plurality of coronary arteries emanating from the portion of the aorta;", 'create a three-dimensional model representing the portion of the anatomical structure based on the patient-specific data;', 'create a physics-based model relating to a blood flow characteristic within the portion of the anatomical structure; and', 'determine a fractional flow reserve within the portion of the anatomical structure based on the three-dimensional model and the physics-based model., 'at least one computer system configured to2. The system of claim 1 , wherein the at least one computer system is configured to determine the fractional flow reserve within the plurality of coronary arteries.3. The system of claim 1 , wherein:the fractional flow reserve indicates ...

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Номер записи: 109
28-02-2013 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20130054214A1
Автор: Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184.-. (canceled)185. A method for assessing a coronary artery of a patient , the method comprising:viewing, on a digital display device, a three-dimensional model of at least a portion of multiple coronary arteries branching from an aorta of the patient, wherein the three-dimensional model is provided by a computer system;viewing, on the display device, a first fractional flow reserve calculated by the computer system for at least one of the coronary arteries in the three-dimensional model;providing an input to the computer system related to a treatment plan for the at least one of the coronary arteries; andviewing, on the display device, a second fractional flow reserve calculated by the computer system for the at least one of the coronary arteries, wherein calculation of the second fractional flow reserve is based at least in part on the input.186. A method as in claim 185 , wherein viewing the first fractional flow reserve and viewing the second fractional flow reserve include viewing separate first and second fractional flow reserves calculated for each of multiple coronary arteries.187. A method as in claim 185 , further comprising:viewing, on the display device, a first value for at least one additional physiological parameter, wherein the first value is calculated by the computer system; andviewing, on the display device after ...

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Номер записи: 110
14-03-2013 дата публикации

Method and system for patient-specific modeling of blood flow

Номер: US20130064438A1
Автор: Charles A. Taylor, Christopher K. Zarins, Gilwoo Choi, Timothy A. Fonte, Ying Bai
Принадлежит: HeartFlow Inc

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 111
13-06-2013 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20130151163A1
Автор: Bai Ying, Choi Gilwoo, Fonte Timothy A., Taylor Charles A., Zarins Christopher K.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1. A system for determining cardiovascular information for a patient , the system comprising: ["receive patient-specific data regarding a geometry of the patient's heart;", "create a three-dimensional model representing at least a portion of the patient's heart based on the patient specific data;", "create a physics-based model relating to a blood flow characteristic of the patient's heart; and", "determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model."], 'at least one computer system configured to2184-. (canceled) This application claims the benefit of priority from U.S. Provisional Application No. 61/401,462, filed Aug. 12, 2010, U.S. Provisional Application No. 61/401,915, filed Aug. 20, 2010, U.S. Provisional Application No. 61/402,308, filed Aug. 26, 2010, U.S. Provisional Application No. 61/402,345, filed Aug. 27, 2010, and U.S. Provisional Application No. 61/404,429, filed Oct. 1, 2010, which are herein incorporated by reference in their entirety.Embodiments include methods and systems for modeling of fluid flow and more particularly methods and systems for patient-specific modeling of blood flow.Coronary artery disease may produce coronary lesions in the blood vessels providing blood to the heart, such as a stenosis (abnormal narrowing of a blood vessel). ...

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Номер записи: 112
03-01-2019 дата публикации

METHOD AND SYSTEM FOR IMAGE PROCESSING TO DETERMINE BLOOD FLOW

Номер: US20190000554A1
Автор: Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A method for processing images to determine cardiovascular information , comprising the steps of:receiving image data including a plurality of coronary arteries originating from an aorta;processing the image data to generate three-dimensional shape models of the coronary arteries;simulating a blood flow for the generated three-dimensional shape models of the coronary arteries; anddetermining a fractional flow reserve (FFR) of the coronary arteries based on a blood flow simulation result, wherein in the step of simulating the blood flow, a computational fluid dynamics model is applied to the three-dimensional shape models of the coronary arteries, a lumped parameter model is combined with the computational fluid dynamics model, and a simplified coronary artery circulation model including coronary arteries, capillaries of the coronary arteries and coronary veins is used as the lumped parameter model.186. The method of claim 185 , wherein claim 185 , when simulating the blood flow claim 185 , when applying the computational fluid dynamics model to the three-dimensional shape models of the coronary arteries claim 185 , using an aorta blood pressure pattern as an inlet boundary condition.187. The method of claim 185 , wherein simulating the blood flow comprises determining lengths of centerlines of the three- ...

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Номер записи: 113
05-01-2017 дата публикации

SYSTEMS AND METHODS FOR IMAGE PROCESSING FOR MODELING CHANGES IN PATIENT-SPECIFIC BLOOD VESSEL GEOMETRY AND BOUNDARY CONDITIONS

Номер: US20170004280A1
Автор: Choi Gilwoo, EBERLE David, Grady Leo, Kim Hyun Jin, SANKARAN Sethuraman, SCHAAP Michiel, Taylor Charles A.
Принадлежит:

Systems and methods are disclosed for modeling changes in patient-specific blood vessel geometry and boundary conditions resulting from changes in blood flow or pressure. One method includes determining, using a processor, a first anatomic model of one or more blood vessels of a patient; determining a biomechanical model of the one or more blood vessels based on at least the first anatomic model; determining one or more parameters associated with a physiological state of the patient; and creating a second anatomic model based on the biomechanical model and the one or more parameters associated with the physiological state. 120-. (canceled)21. A method for determining a quantity of interest of a patient , comprising: receiving patient data of the patient at a first physiological state;determining a value of a quantity of interest of the patient at the first physiological state based on the patient data, the quantity of interest representing a medical characteristic of the patient;extracting features from the patient data, wherein the extracted features are used to determine the quantity of interest to be determined for the patient at a second physiological state; andmapping the value of the quantity of interest of the patient at the first physiological state to a value of the quantity of interest of the patient at the second physiological state using the extracted features.22. The method as recited in claim 21 , wherein mapping the value of the quantity of interest of the patient at the first physiological state to the value of the quantity of interest of the patient at the second physiological state further comprises:mapping the value of the quantity of interest of the patient at the first physiological state to the value of the quantity of interest of the patient at the second physiological state without using data of the patient at the second physiological state.23. The method as recited in claim 21 , wherein the quantity of interest of the patient at the first ...

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Номер записи: 114
14-01-2016 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20160007945A1
Автор: Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A method for vascular assessment comprising:receiving a plurality of 2D angiographic images of a portion of a vasculature of a subject, and processing said images to produce a stenotic model over the vasculature, said stenotic model having measurements of the vasculature at one or more locations along vessels of the vasculature;obtaining a flow characteristic of the stenotic model; andcalculating an index indicative of vascular function, based, at least in part, on the flow characteristic in the stenotic model.186. The method according to claim 185 , wherein said measurements of the vasculature are at one or more locations along a centerline of at least one branch of the vasculature.187. The method according to claim 185 , wherein said flow characteristic of said stenotic model comprises resistance to fluid flow.188. The method according to claim 187 , further comprising identifying in said first stenotic model a stenosed vessel and a downstream portion of said stenosed vessel claim 187 , and calculating said resistance to fluid flow in said downstream portion;wherein said index is calculated based on a volume of said downstream portion, and on a contribution of said stenosed vessel to said resistance to fluid flow.189. The method according to claim 185 , wherein said flow characteristic of said stenotic model ...

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Номер записи: 115
14-01-2021 дата публикации

SYSTEMS AND METHODS FOR TREATMENT PLANNING BASED ON PLAQUE PROGRESSION AND REGRESSION CURVES

Номер: US20210007807A1
Автор: Choi Gilwoo, Grady Leo, SANKARAN Sethuraman, SCHAAP Michiel, Taylor Charles A., Zarins Christopher K.
Принадлежит:

Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of a location of disease in the patient's vasculature based on the received patient-specific data; identifying one or more changes in geometry of the anatomic model based on a modeled progression or regression of disease at the location; calculating one or more values of a blood flow characteristic within the patient's vasculature using a computational model based on the identified one or more changes in geometry of the anatomic model; and generating an electronic graphical display of a relationship between the one or more values of the calculated blood flow characteristic and the identified one or more changes in geometry of the anatomic model. 120-. (canceled)21. A computer-implemented method of evaluating a patient with vascular disease , the method comprising:receiving patient-specific image data regarding a geometry of the patient's vasculature;creating, based on the received patient-specific image data, a patient-specific anatomic model representing a diseased region of the patient's vasculature at a first point of time;computing a characteristic of plaque using one or more image features of the received patient-specific image data;predicting, using the computed characteristic of plaque, a change to a geometric parameter of the diseased region of the patient's vasculature at a second point of time;modifying a geometry of the patient-specific anatomic model to include the predicted change to the geometric parameter of the diseased region at the second point in time; andcomputing a value of a vessel characteristic using the modified patient-specific anatomic model.22. The computer-implemented method of claim 21 ,generating a treatment recommendation or risk assessment based on the computed value of the vessel ...

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Номер записи: 116
10-01-2019 дата публикации

METHOD AND SYSTEM FOR QUANTIFYING LIMITATIONS IN CORONARY ARTERY BLOOD FLOW DURING PHYSICAL ACTIVITY IN PATIENTS WITH CORONARY ARTERY DISEASE

Номер: US20190008462A1
Автор: Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient with coronary artery disease. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart and create a model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create, for a given level of physical activity, a physics-based model of blood flow through the patient's heart simulated during a selected level of physical activity; determine and normalize one or more values of at least one blood flow characteristic within the patient's heart during the simulated level of physical activity; and compare the one or more normalized values of the at least one blood flow characteristic to a threshold to determine whether the level of physical activity exceeds an acceptable level of risk. 130-. (canceled)31. A system for quantifying limitations in coronary artery blood flow during exercise in a patient with coronary artery disease , the system comprising:at least one computer system configured for:receiving data regarding geometry of a patient's vasculature;creating a geometric model representing the geometry of at least a portion of the patient's vasculature, the geometric model reflecting vascular geometry at a first physiological state;computing, using the geometric model, a blood flow characteristic of blood flow through the geometric model for a second physiological state, different from the first physiological state; anddetermining a score quantifying a risk of a of injury to the patient at the second physiological state, based on the computed blood flow characteristic.32. The system of claim 31 , wherein the at least one computer system is further configured for:generating a physics-based model based on the geometric model; andcomputing the blood flow based on the physics-based model.33. The system of claim ...

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Номер записи: 117
19-01-2017 дата публикации

SYSTEMS AND METHODS FOR ESTIMATING HEMODYNAMIC FORCES ACTING ON PLAQUE AND MONITORING PATIENT RISK

Номер: US20170014033A1
Автор: Choi Gilwoo, Kim Hyun Jin, KOO Bon-Kwon, Taylor Charles A.
Принадлежит:

Computer-implemented methods are disclosed for estimating values of hemodynamic forces acting on plaque or lesions. One method includes: receiving one or more patient-specific parameters of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion; constructing a patient-specific geometric model of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion, using the received one or more patient-specific parameters; estimating, using one or more processors, the values of hemodynamic forces at one or more points on the patient-specific geometric model, using the patient-specific parameters and geometric model by measuring, deriving, or obtaining one or more of a pressure gradient and a radius gradient; and outputting the estimated values of hemodynamic forces to an electronic storage medium. Systems and computer readable media for executing these methods are also disclosed. 120-. (canceled)21. A method for estimating values of hemodynamic forces acting on a plaque or lesion , the method comprising:receiving one or more patient-specific parameters of a vascular system, from each of a plurality of individuals with known values of hemodynamic forces at one or more points of a vascular system;constructing a geometric model of the vascular system, using the received one or more patient-specific parameters, for each of a plurality of individuals with known values of hemodynamic forces at one or more points of a vascular system;receiving values of hemodynamic forces acting on the one or more points of the constructed patient-specific geometric model, from each of the plurality of individuals with known values of hemodynamic forces at one or more points of the vascular system;forming feature vectors comprising of information regarding the location of the one or more points on the geometric model with the known values of hemodynamic forces and the received patient-specific parameters at ...

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Номер записи: 118
19-01-2017 дата публикации

SYSTEMS AND METHODS FOR ESTIMATING HEMODYNAMIC FORCES ACTING ON PLAQUE AND MONITORING PATIENT RISK

Номер: US20170014034A1
Автор: Choi Gilwoo, Kim Hyun Jin, KOO Bon-Kwon, Taylor Charles A.
Принадлежит:

Computer-implemented methods are disclosed for estimating values of hemodynamic forces acting on plaque or lesions. One method includes: receiving one or more patient-specific parameters of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion; constructing a patient-specific geometric model of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion, using the received one or more patient-specific parameters; estimating, using one or more processors, the values of hemodynamic forces at one or more points on the patient-specific geometric model, using the patient-specific parameters and geometric model by measuring, deriving, or obtaining one or more of a pressure gradient and a radius gradient; and outputting the estimated values of hemodynamic forces to an electronic storage medium. Systems and computer readable media for executing these methods are also disclosed. 120-. (canceled)21. A computer implemented method for determining exercise intensity using estimated values of hemodynamic forces acting on a plaque or lesion , the method comprising:measuring patient-specific physiological stress characteristics during a period or immediately after a period of physical activity, causing physiological stress in a patient;receiving one or more patient-specific parameters of at least a portion of the patient's vasculature that is prone to lesions or plaque rupture;constructing a patient-specific geometric model of at least a portion of the patient's vasculature that is prone to lesions or plaque rupture, using the received one or more patient-specific parameters;estimating maximum values for hemodynamic forces on one or more points on the patent-specific geometric model using one or more of the patient-specific physiological stress characteristics, the patient-specific parameters, and the geometric model, using one or more processors; andoutputting the estimated maximum ...

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Номер записи: 119
19-01-2017 дата публикации

SYSTEMS AND METHODS FOR ESTIMATING HEMODYNAMIC FORCES ACTING ON PLAQUE AND MONITORING PATIENT RISK

Номер: US20170017771A1
Автор: Choi Gilwoo, Kim Hyun Jin, KOO Bon-Kwon, Taylor Charles A.
Принадлежит:

Computer-implemented methods are disclosed for estimating values of hemodynamic forces acting on plaque or lesions. One method includes: receiving one or more patient-specific parameters of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion; constructing a patient-specific geometric model of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion, using the received one or more patient-specific parameters; estimating, using one or more processors, the values of hemodynamic forces at one or more points on the patient-specific geometric model, using the patient-specific parameters and geometric model by measuring, deriving, or obtaining one or more of a pressure gradient and a radius gradient; and outputting the estimated values of hemodynamic forces to an electronic storage medium. Systems and computer readable media for executing these methods are also disclosed. 1. A computer implemented method for estimating values of hemodynamic forces acting on plaque or lesions , the method comprising:receiving one or more patient-specific parameters of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion;constructing a patient-specific geometric model of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion, using the received one or more patient-specific parameters;estimating, using one or more processors, the values of hemodynamic forces at one or more points on the patient-specific geometric model, using the patient-specific parameters and geometric model by measuring, deriving, or obtaining one or more of a pressure gradient and a radius gradient; andoutputting the estimated values of hemodynamic forces to an electronic storage medium.2. The computer implemented method of claim 1 , wherein constructing a patient-specific geometric model includes: computerized tomography,', ' ...

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Номер записи: 120
19-01-2017 дата публикации

SYSTEMS AND METHODS FOR ASSESSING THE SEVERITY OF PLAQUE AND/OR STENOTIC LESIONS USING CONTRAST DISTRIBUTION PREDICTIONS AND MEASUREMENTS

Номер: US20170018081A1
Автор: Grady Leo, Kim Hyun Jin, SANKARAN Sethuraman, Sengupta Souma, Taylor Charles A., XIAO Nan
Принадлежит:

Systems and methods are disclosed for assessing the severity of plaque and/or stenotic lesions using contrast distribution predictions and measurements. One method includes: receiving patient-specific images of a patient's vasculature and a measured distribution of a contrast agent delivered through the patient's vasculature; associating the measured distribution of the contrast agent with a patient-specific anatomic model of the patient's vasculature; defining physiological and boundary conditions of a blood flow model of the patient's blood flow and pressure; simulating the distribution of the contrast agent through the patient-specific anatomic model; comparing the measured distribution of the contrast agent and the simulated distribution of the contrast agent through the patient-specific anatomic model to determine whether a similarity condition is satisfied; and updating the defined physiological and boundary conditions and re-simulating distribution of the contrast agent through the one or more points of the patient-specific anatomic model until the similarity condition is satisfied. 1. A computer implemented method for non-invasively estimating blood flow characteristics to assess the severity of plaque and/or stenotic lesions using contrast distribution predictions and measurements , the method comprising:receiving one or more patient-specific images of at least a portion of a patient's vasculature and a measured distribution of a contrast agent delivered through the patient's vasculature;associating the measured distribution of the contrast agent at points of the patient's vasculature with one or more points of a patient-specific anatomic model of the patient's vasculature generated using the received patient-specific images;defining one or more physiological and boundary conditions of a blood flow model for non-invasively estimating the patient's blood flow and pressure and simulating a distribution of the contrast agent through the patient-specific ...

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Номер записи: 121
17-01-2019 дата публикации

SYSTEMS AND METHODS FOR PREDICTING LOCATION, ONSET, AND/OR CHANGE OF CORONARY LESIONS

Номер: US20190019289A1
Автор: Choi Gilwoo, Grady Leo, Taylor Charles A.
Принадлежит:

Systems and methods are disclosed for predicting the location, onset, or change of coronary lesions from factors like vessel geometry, physiology, and hemodynamics. One method includes: acquiring, for each of a plurality of individuals, a geometric model, blood flow characteristics, and plaque information for part of the individual's vascular system; training a machine learning algorithm based on the geometric models and blood flow characteristics for each of the plurality of individuals, and features predictive of the presence of plaque within the geometric models and blood flow characteristics of the plurality of individuals; acquiring, for a patient, a geometric model and blood flow characteristics for part of the patient's vascular system; and executing the machine learning algorithm on the patient's geometric model and blood flow characteristics to determine, based on the predictive features, plaque information of the patient for at least one point in the patient's geometric model. 129-. (canceled)30. A computer-implemented method for predicting information relating to a vascular lesion of a patient , the method comprising:creating a feature vector comprising characteristics at each of a plurality of points in a geometric model, for each of a plurality of individuals;associating each feature vector with an estimate of a probability of plaque growth, shrinkage, or onset, for each of the plurality of points in the geometric model, for each of the plurality of individuals;creating a feature vector comprising characteristics at each of a plurality of points in a patient-specific geometric model of a patient's vasculature, for a patient different from the plurality of individuals;comparing the patient-specific geometric model of the patient's vasculature to the geometric models of the plurality of individuals, to identify feature vectors common between the patient and each of the plurality of individuals;identifying a selected point of a geometric model of a ...

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Номер записи: 122
17-04-2014 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20140107935A1
Автор: Taylor Charles A.
Принадлежит: HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A method for non-invasive assessment of coronary artery stenosis , comprising:extracting patient-specific anatomical measurements of the coronary arteries from medical image data of a patient acquired during rest state;calculating patient-specific rest state boundary conditions of a model of coronary circulation representing the coronary arteries based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest;calculating patient-specific hyperemic boundary conditions of the model of coronary circulation based on the rest boundary conditions and a model for simulated hyperemia;simulating hyperemic blood flow and pressure across at least one stenosis region of at least one coronary artery using the model of coronary circulation and the patient-specific hyperemic boundary conditions; andcalculating fractional flow reserve (FFR) of the at least one stenosis region based on the simulated hyperemic blood flow and pressure.186. The method of claim 185 , wherein the coronary circulation model comprises one-dimensional computational models representing the coronary arteries and aorta of the patient.187. The method of claim 186 , wherein the coronary circulation model further comprises a reduced order semi-empirical stenosis model representing the at least one stenosis ...

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Номер записи: 123
04-02-2016 дата публикации

SYSTEMS AND METHODS FOR PREDICTING CORONARY PLAQUE VULNERABILITY FROM PATIENT-SPECIFIC ANATOMIC IMAGE DATA

Номер: US20160030127A1
Автор: Choi Gilwoo, Grady Leo, SCHAAP Michiel, Taylor Charles A.
Принадлежит:

Systems and methods are disclosed for predicting coronary plaque vulnerability, using a computer system. One method includes acquiring anatomical image data of at least part of the patient's vascular system; performing, using a processor, one or more image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical image data; predicting, using the processor, a coronary plaque vulnerability present in the patient's vascular system, wherein predicting the coronary plaque vulnerability includes calculating an adverse plaque characteristic based on results of the one or more of image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis of the anatomical image data; and reporting, using the processor, the calculated adverse plaque characteristic. 1. A computer-implemented method of determining an effect of a treatment on coronary plaque vulnerability , the method comprising:acquiring anatomical image data of at least part of a patient's vascular system;performing, using a processor, one or more of image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical image data;predicting, using the processor, a coronary plaque vulnerability present in the patient's vascular system based on results of one or more of the image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis of the anatomical image data;modifying one or more of the image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical image data based on a proposed treatment; anddetermining an effect of the treatment on the coronary plaque vulnerability based on the modified one or more of the image characteristics analysis, geometrical ...

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Номер записи: 124
11-02-2016 дата публикации

SYSTEMS AND METHODS FOR IDENTIFYING PERSONALIZED VASCULAR IMPLANTS FROM PATIENT-SPECIFIC ANATOMIC IMAGE DATA

Номер: US20160038251A1
Автор: Choi Gilwoo, GRADY Leo J., ROGERS Campbell, Taylor Charles A.
Принадлежит:

Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising acquiring a geometric model of at least a portion of a patient's vascular system; obtaining one or more geometric quantities of one or more blood vessels of the geometric model of the patient's vascular system; determining the presence or absence of a pathology characteristic at a location in the geometric model of the patient's vascular system; generating an objective function defined by a plurality of device variables and a plurality of hemodynamic and solid mechanics characteristics; and optimizing the objective function using computational fluid dynamics and structural mechanics analysis to identify a plurality of device variables that result in desired hemodynamic and solid mechanics characteristics. 1. A method of identifying a personalized cardiovascular device based on patient-specific geometrical information , the method comprising:acquiring a geometric model of at least a portion of a patient's vascular system;obtaining one or more geometric quantities of one or more blood vessels of the geometric model of the patient's vascular system;determining the presence or absence of a pathology characteristic at a location in the geometric model of the patient's vascular system;generating an objective function defined by a plurality of device variables and a plurality of hemodynamic and solid mechanics characteristics; andoptimizing the objective function using computational fluid dynamics and structural mechanics analysis to identify a plurality of device variables that result in desired hemodynamic and solid mechanics characteristics.2. The method of claim 1 , wherein the device includes an implantable device or a device for delivery of an implantable device.3. The method of claim 1 , further comprising acquiring one or more physiological parameters chosen from patient age claim 1 , gender claim 1 , height claim ...

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Номер записи: 125
05-02-2015 дата публикации

METHOD AND SYSTEM FOR MODELING BLOOD FLOW WITH BOUNDARY CONDITIONS FOR OPTIMIZED DIAGNOSTIC PERFORMANCE

Номер: US20150038860A1
Автор: Fonte Timothy A., KHEM Sophie, Kim Hyun Jin, Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1. A system for determining cardiovascular information for a patient , the system comprising: retrieving data for each of a plurality of patients, the data including an invasively obtained measurement of blood flow characteristic and a blood flow characteristic computed based at least in part on a respective boundary condition; and', 'determining boundary conditions tuning characteristics by iteratively comparing computed blood flow characteristics to invasively obtained measurements of blood flow characteristics of each of the patients., 'at least one computer system configured to execute a method, the method comprising2. The system of claim 1 , wherein determining boundary conditions tuning characteristics comprises determining boundary conditions tuning characteristics that tune the respective boundary conditions to reduce a difference between the computed blood flow characteristics and the invasively obtained measurements of blood flow characteristics of each of the patients.3. The system of claim 2 , wherein the data further includes invasively obtained measurements of blood flow characteristics at a plurality of anatomical locations and corresponding computed blood flow characteristics for each of the patients based on at least part on respective boundary condition models at the plurality of anatomical locations.4. The system of ...

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Номер записи: 126
11-02-2016 дата публикации

SYSTEMS AND METHODS FOR TREATMENT PLANNING BASED ON PLAQUE PROGRESSION AND REGRESSION CURVES

Номер: US20160042144A1
Автор: Choi Gilwoo, GRADY Leo J., SANKARAN Sethuraman, SCHAAP Michiel, Taylor Charles A., Zarins Christopher K.
Принадлежит:

Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of a location of disease in the patient's vasculature based on the received patient-specific data; identifying one or more changes in geometry of the anatomic model based on a modeled progression or regression of disease at the location; calculating one or more values of a blood flow characteristic within the patient's vasculature using a computational model based on the identified one or more changes in geometry of the anatomic model; and generating an electronic graphical display of a relationship between the one or more values of the calculated blood flow characteristic and the identified one or more changes in geometry of the anatomic model. 120-. (canceled)21. A computer-implemented method of evaluating a patient with vascular disease , the method comprising:receiving patient-specific data regarding a geometry of the patient's vasculature;determining a plaque remodeling characteristic characterizing a propensity of the disease in the patient's vasculature to progress or regress;determining, using the received patient-specific data and the determined plaque remodeling characteristic, a geometric model of a progression or regression of disease at a location in the patient's vasculature;calculating a value of a blood flow characteristic within the patient's vasculature using a blood flow model determined based on the received patient-specific data and the determined plaque remodeling characteristic; andgenerating a treatment recommendation or risk assessment based on the value of the blood flow characteristic calculated using the blood flow model based on the received patient-specific data and the determined plaque remodeling characteristic.22. The computer-implemented method of claim 21 , wherein the treatment ...

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Номер записи: 127
09-02-2017 дата публикации

METHODS AND SYSTEMS FOR PREDICTING SENSITIVITY OF BLOOD FLOW CALCULATIONS TO CHANGES IN ANATOMICAL GEOMETRY

Номер: US20170039340A1
Автор: Grady Leo, SANKARAN Sethuraman, Taylor Charles A.
Принадлежит:

Embodiments include methods and systems and for determining a sensitivity of a patient's blood flow characteristic to anatomical or geometrical uncertainty. For each of one or more of individuals, a sensitivity of a blood flow characteristic may be obtained for one or more uncertain parameters. An algorithm may be trained based on the sensitivities of the blood flow characteristic and one or more of the uncertain parameters for each of the plurality of individuals. A geometric model, a blood flow characteristic, and one or more of the uncertain parameters of at least part of the patient's vascular system may be obtained for a patient. The sensitivity of the patient's blood flow characteristic to one or more of the uncertain parameters may be calculated by executing the algorithm on the blood flow characteristic of at least part of the patient's vascular system, and one or more of the uncertain parameters. 120-. (canceled)21. A computer-implemented method of determining a sensitivity of a patient's blood flow characteristic to uncertainty in a geometric model of a patient's vascular system , the method comprising:obtaining, for each of a plurality of individuals, a geometric model of at least a portion of a vascular system of each individual;calculating, for each geometric model, at least one sensitivity of a blood flow characteristic to at least one uncertainty in geometry in the geometric model;identifying a plurality of features of each geometric model;mapping the identified features to the calculated sensitivities in a machine learning database;generating, for a patient, a geometric model of at least part of the patient's vascular system using patient-specific imaging data of at least a portion of the patient's vascular system;determining, for the patient, a designation of a blood flow characteristic, a designation of at least one feature, and at least one value of uncertainty in geometry in the geometric model of at least part of the patient's vascular system; ...

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Номер записи: 128
15-02-2018 дата публикации

SYSTEMS AND METHODS FOR MODELING NUTRIENT TRANSPORT AND/OR PREDICTING WEIGHT CHANGE

Номер: US20180047304A1
Автор: Grady Leo, SANKARAN Sethuraman, Taylor Charles A., ZARINS CHRISTOPHER
Принадлежит:

Systems and methods are disclosed for identifying and modeling unresolved vessels, and the effects thereof, in image-based patient-specific hemodynamic models. One method includes: receiving a patient-specific anatomical model of at least a portion of a visceral vascular system of the patient; receiving patient-specific information related to the patient's food intake; generating a patient-specific model of blood flow in the patient-specific anatomical model of the portion of the visceral vascular system of the patient; generating a patient-specific model of nutrient transport from at least a part of a gastrointestinal system of the patient to the portion of the visceral vascular system of the patient based on the patient-specific information related to the patient's food intake; and determining an indicia of energy available in the patient based on the patient-specific model of nutrient transport. 1. A computer-implemented method of modeling nutrient transport within a patient , the method comprising:receiving, in an electronic storage medium, a patient-specific anatomical model of at least a portion of a visceral vascular system of the patient;receiving, in an electronic storage medium, patient-specific information related to the patient's food intake;generating a patient-specific model of blood flow in the patient-specific anatomical model of the portion of the visceral vascular system of the patient;generating a patient-specific model of nutrient transport from at least a part of a gastrointestinal system of the patient to the portion of the visceral vascular system of the patient based on the patient-specific information related to the patient's food intake; anddetermining an indicia of energy available in the patient based on the patient-specific model of nutrient transport.2. The computer-implemented method of claim 1 , further comprising:simulating blood flow through hepatic and portal blood vessels of the patient based on the patient-specific model of ...

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Номер записи: 129
19-02-2015 дата публикации

SYSTEMS AND METHODS FOR IDENTIFYING PERSONALIZED VASCULAR IMPLANTS FROM PATIENT-SPECIFIC ANATOMIC DATA

Номер: US20150051884A1
Автор: Choi Gilwoo, Grady Leo, ROGERS Campbell, Taylor Charles A.
Принадлежит: HEARTFLOW, INC.

Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising acquiring an anatomical model of at least part of the patient's vascular system; performing, using a processor, one or more of geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical model; and identifying, using the processor, a personalized cardiovascular device for the patient, based on results of one or more of the geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis of anatomical model. 1. A computer-implemented method of identifying a personalized cardiovascular device based on patient-specific geometrical information , the method comprising:acquiring an anatomical model of at least part of a patient's vascular system;identifying the presence of disease at one or more locations of the anatomical model;defining one or more design variables of a personalized cardiovascular device to treat the disease;defining one or more performance metrics of the personalized cardiovascular device, the one or more performance metrics being chosen from one or more of: flow mechanic characteristics, solid mechanics characteristics, cost characteristics, and clinical event characteristics, wherein values of the one or more performance metrics are a function of values of the one or more design variables;performing, using a computer processor, one or more of geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical model;iteratively updating the values of the one or more design variables to calculate updated values of the one or more performance metrics by using one or more iterative updates of the anatomical model, each iterative update of the anatomical model taking into account deployment of an iteration of the personalized cardiovascular device; andidentifying, using a computer ...

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Номер записи: 130
19-02-2015 дата публикации

SYSTEMS AND METHODS FOR IDENTIFYING PERSONALIZED VASCULAR IMPLANTS FROM PATIENT-SPECIFIC ANATOMIC DATA

Номер: US20150051885A1
Автор: Choi Gilwoo, Grady Leo, ROGERS Campbell, Taylor Charles A.
Принадлежит: HEARTFLOW, INC.

Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising acquiring a geometric model of at least a portion of a patient's vascular system; obtaining one or more geometric quantities of one or more blood vessels of the geometric model of the patient's vascular system; determining the presence or absence of a pathology characteristic at a location in the geometric model of the patient's vascular system; generating an objective function defined by a plurality of device variables and a plurality of hemodynamic and solid mechanics characteristics; and optimizing the objective function using computational fluid dynamics and structural mechanics analysis to identify a plurality of device variables that result in desired hemodynamic and solid mechanics characteristics. 1. A computer-implemented method of identifying a personalized cardiovascular device based on patient-specific geometrical information , the method comprising:acquiring a geometric model of at least a portion of a patient's vascular system;obtaining one or more geometric quantities of one or more blood vessels of the geometric model of the patient's vascular system;determining the presence of a pathology characteristic at a location in the geometric model based on the one or more geometric quantities;defining one or more device variables of a personalized cardiovascular device to treat the pathology characteristic;generating an objective function defined by the one or more device variables and hemodynamic or solid mechanics performance characteristics of the personalized cardiovascular device; andoptimizing the objective function to identify a plurality of values of the one or more device variables that result in desired hemodynamic or solid mechanics performance characteristics of the personalized cardiovascular device, by performing one or both of computational fluid dynamics and structural mechanics analyses on ...

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Номер записи: 131
19-02-2015 дата публикации

Systems and methods for identifying personalized vascular implants from patient-specific anatomic data

Номер: US20150051886A1
Автор: Campbell Rogers, Charles A. Taylor, Gilwoo Choi, Leo Grady
Принадлежит: HeartFlow Inc

Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising: generating a patient specific model of at least a portion of a patient's vasculature from image data of the patient's vasculature and one or more measured or estimated physiological or phenotypic parameters of the patient; determining pathology characteristics from cardiovascular geometry of the patient specific model; defining an objective function for a device based on design considerations and one or more estimates of hemodynamic and mechanical characteristics; optimizing the objective function, by simulating at least one change in devices and evaluating the objective function using fluid dynamic or structural mechanic analyses; and using the optimized objective function to either (i) select a device from a set of available devices or (ii) manufacture a desired device.

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Номер записи: 132
03-03-2016 дата публикации

SYSTEMS AND METHODS FOR AUTOMATICALLY DETERMINING MYOCARDIAL BRIDGING AND PATIENT IMPACT

Номер: US20160063175A1
Автор: Choi Gilwoo, Taylor Charles A.
Принадлежит:

Embodiments include computer-implemented methods and systems for reporting the presence of myocardial bridging in a patient, the method comprising detecting, within a patient-specific model representing at least a portion of the patient's heart based on patient-specific anatomical image data regarding a geometry of the patient's heart, a segment of an epicardial coronary artery at least partially surrounded by the patient's myocardium to determine the presence of myocardial bridging; and computing, using at least one computer processor, at least one physical feature of the myocardial bridging to identify the severity of the myocardial bridging. 1. A computer-implemented method for reporting the presence of myocardial bridging in a patient , the method comprising:receiving a patient-specific model representing at least a portion of the patient's heart;detecting, within the patient-specific model representing at least the portion of the patient's heart, a segment of an epicardial coronary artery at least partially surrounded by the patient's myocardium to determine the presence of myocardial bridging;computing, using at least one computer processor, at least one physical anatomical feature of the myocardial bridging from the detected segment of the patient-specific model including the epicardial coronary artery at least partially surrounded by the patient's myocardium; anddetermining a severity score of the myocardial bridging using the physical anatomical feature of the myocardial bridging computed from the patient-specific model.2. The method of claim 1 , further comprising storing the determined presence of myocardial bridging and the at least one physical anatomical feature of the myocardial bridging.3. The method of claim 1 , wherein the patient-specific model is based on patient-specific anatomical image data of a geometry of the patient's heart claim 1 , including geometry of the patient's ascending aorta claim 1 , coronary artery tree claim 1 , and myocardium. ...

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Номер записи: 133
05-03-2015 дата публикации

SYSTEMS AND METHODS FOR PREDICTING LOCATION, ONSET, AND/OR CHANGE OF CORONARY LESIONS

Номер: US20150065846A1
Автор: Choi Gilwoo, Grady Leo, Taylor Charles A.
Принадлежит:

Systems and methods are disclosed for predicting the location, onset, or change of coronary lesions from factors like vessel geometry, physiology, and hemodynamics. One method includes: acquiring, for each of a plurality of individuals, a geometric model, blood flow characteristics, and plaque information for part of the individual's vascular system; training a machine learning algorithm based on the geometric models and blood flow characteristics for each of the plurality of individuals, and features predictive of the presence of plaque within the geometric models and blood flow characteristics of the plurality of individuals; acquiring, for a patient, a geometric model and blood flow characteristics for part of the patient's vascular system; and executing the machine learning algorithm on the patient's geometric model and blood flow characteristics to determine, based on the predictive features, plaque information of the patient for at least one point in the patient's geometric model. 129-. (canceled)30. A computer-implemented method for predicting information relating to a vascular lesion of a patient , the method comprising:receiving, for each of a plurality of individuals, a geometric model including a plurality of points, and an estimate of a probability of plaque growth, shrinkage, or onset at each of the plurality of points;receiving an image of a patient's vasculature;identifying a region of the patient's vasculature as being a possible location of plaque, based on a comparison between the image of the patient's vasculature and the geometry of one or more individuals' geometric models; andgenerating, using a computer processor, a prediction or a probability of a risk of artery disease for the patient at the possible location of plaque, based, at least in part, on one or more of the estimates of probability of plaque growth, shrinkage, or onset at one or more of the plurality of points of the individuals' geometric models.31. The method of claim 30 , further ...

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Номер записи: 134
05-03-2015 дата публикации

SYSTEMS AND METHODS FOR PREDICTING LOCATION, ONSET, AND/OR CHANGE OF CORONARY LESIONS

Номер: US20150065847A1
Автор: Choi Gilwoo, Grady Leo, Taylor Charles A.
Принадлежит:

Systems and methods are disclosed for predicting the location, onset, or change of coronary lesions from factors like vessel geometry, physiology, and hemodynamics. One method includes: acquiring, for each of a plurality of individuals, a geometric model, blood flow characteristics, and plaque information for part of the individual's vascular system; training a machine learning algorithm based on the geometric models and blood flow characteristics for each of the plurality of individuals, and features predictive of the presence of plaque within the geometric models and blood flow characteristics of the plurality of individuals; acquiring, for a patient, a geometric model and blood flow characteristics for part of the patient's vascular system; and executing the machine learning algorithm on the patient's geometric model and blood flow characteristics to determine, based on the predictive features, plaque information of the patient for at least one point in the patient's geometric model. 129-. (canceled)30. A computer-implemented method for predicting information relating to a vascular lesion of an individual , the method comprising:receiving an image of the individual's vasculature;acquiring a geometric model of the individual's vasculature, one or more physiological or phenotypic parameters of the individual, and one or more biophysical hemodynamic characteristics associated with the individual's vasculature;creating one or more associations between the one or more physiological or phenotypic parameters of the individual, the one or more biophysical hemodynamic characteristics of the individual, and each of a plurality of points in the geometric model;estimating, using a processor, a probability of artery disease at each of the plurality of points in the geometric model of the individual's vasculature using the one or more associations and plaque information associated with one or more individuals of a plurality of individuals; andgenerating an electronic display ...

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Номер записи: 135
05-03-2015 дата публикации

SYSTEMS AND METHODS FOR PREDICTING LOCATION, ONSET, AND/OR CHANGE OF CORONARY LESIONS

Номер: US20150065848A1
Автор: Choi Gilwoo, Grady Leo, Taylor Charles A.
Принадлежит:

Systems and methods are disclosed for predicting the location, onset, or change of coronary lesions from factors like vessel geometry, physiology, and hemodynamics. One method includes: acquiring, for each of a plurality of individuals, a geometric model, blood flow characteristics, and plaque information for part of the individual's vascular system; training a machine learning algorithm based on the geometric models and blood flow characteristics for each of the plurality of individuals, and features predictive of the presence of plaque within the geometric models and blood flow characteristics of the plurality of individuals; acquiring, for a patient, a geometric model and blood flow characteristics for part of the patient's vascular system; and executing the machine learning algorithm on the patient's geometric model and blood flow characteristics to determine, based on the predictive features, plaque information of the patient for at least one point in the patient's geometric model. 129-. (canceled)30. A computer-implemented method for predicting information relating to a vascular lesion of an individual , the method comprising:receiving a representation of anatomy for each of a plurality of individuals;acquiring or generating, for each received representation, a geometric model of at least a portion of the individual's vasculature, one or more physiological or phenotypic parameters of the individual, and one or more biophysical hemodynamic characteristics of the individual;creating one or more associations between the one or more physiological or phenotypic parameters of each individual, the one or more biophysical hemodynamic characteristics of each individual, and each of a plurality of points in the respective individual's geometric model;linking each of the one or more created associations with plaque information associated with a respective one of each of the plurality of individuals; andgenerating, using a computer processor and based, at least in part, ...

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Номер записи: 136
10-03-2016 дата публикации

METHOD AND SYSTEM FOR QUANTIFYING LIMITATIONS IN CORONARY ARTERY BLOOD FLOW DURING PHYSICAL ACTIVITY IN PATIENTS WITH CORONARY ARTERY DISEASE

Номер: US20160066861A1
Автор: Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient with coronary artery disease. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart and create a model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create, for a given level of physical activity, a physics-based model of blood flow through the patient's heart simulated during a selected level of physical activity; determine and normalize one or more values of at least one blood flow characteristic within the patient's heart during the simulated level of physical activity; and compare the one or more normalized values of the at least one blood flow characteristic to a threshold to determine whether the level of physical activity exceeds an acceptable level of risk. 1. A system for determining cardiovascular information for a patient with coronary artery disease , the system comprising: ["receive data describing a geometry of at least a portion of the patient's heart;", "determine a three-dimensional model representing the geometry of at least the portion of the patient's heart based on the received data;", 'identify a cardiac event and a blood flow characteristic threshold value associated with the cardiac event;', 'determine a physics-based model of blood flow through the three-dimensional model simulated at a selected level of physical activity of the patient;', 'model the flow of blood through the three-dimensional model using the physics-based model of blood flow through the three-dimensional model simulated at the selected level of physical activity;', "calculate, from the modeled flow of blood through the three-dimensional model simulated at the selected level of physical activity, a value of the blood flow characteristic within the patient's heart at the selected level of physical ...

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Номер записи: 137
10-03-2016 дата публикации

METHOD AND SYSTEM FOR QUANTIFYING LIMITATIONS IN CORONARY ARTERY BLOOD FLOW DURING PHYSICAL ACTIVITY IN PATIENTS WITH CORONARY ARTERY DISEASE

Номер: US20160066862A1
Автор: Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient with coronary artery disease. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart and create a model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create, for a given level of physical activity, a physics-based model of blood flow through the patient's heart simulated during a selected level of physical activity; determine and normalize one or more values of at least one blood flow characteristic within the patient's heart during the simulated level of physical activity; and compare the one or more normalized values of the at least one blood flow characteristic to a threshold to determine whether the level of physical activity exceeds an acceptable level of risk. 130-. (canceled)31. A system for evaluating risk associated with physical activity in a patient , the system comprising: ["receive data regarding geometry of the patient's heart;", "determine a three-dimensional model representing the geometry of at least a portion of the patient's head;", 'receive a physical activity intensity level of the patient and a blood flow characteristic threshold value associated with a cardiac event;', 'determine a physics-based model of blood flow through the three-dimensional model simulated at the physical activity intensity level;', 'model the flow of blood through the three-dimensional model using the determined physics-based model of blood flow through the three-dimensional model simulated at the physical activity intensity level;', "calculate, from the modeled flow of blood through the three-dimensional model simulated at the physical activity intensity level, at least one value of at least one blood flow characteristic within the patient's heart at the physical activity intensity level; and"], ' ...

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Номер записи: 138
10-03-2016 дата публикации

METHOD AND SYSTEM FOR QUANTIFYING LIMITATIONS IN CORONARY ARTERY BLOOD FLOW DURING PHYSICAL ACTIVITY IN PATIENTS WITH CORONARY ARTERY DISEASE

Номер: US20160070877A1
Автор: Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient with coronary artery disease. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart and create a model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create, for a given level of physical activity, a physics-based model of blood flow through the patient's heart simulated during a selected level of physical activity; determine and normalize one or more values of at least one blood flow characteristic within the patient's heart during the simulated level of physical activity; and compare the one or more normalized values of the at least one blood flow characteristic to a threshold to determine whether the level of physical activity exceeds an acceptable level of risk. 130-. (canceled)31. A system for determining an activity level recommendation for a patient , the system comprising: ["receive data describing a geometry of at least a portion of a patient's heart;", "determine a three-dimensional model representing the geometry of at least the portion of the patient's heart based on the received data;", 'determine a physics-based model of blood flow through the three-dimensional model simulated at a selected level of physical activity of the patient;', 'model the flow of blood through the three-dimensional model using the physics-based model of blood flow through the three-dimensional model simulated at the selected level of physical activity;', 'determine one or more stored patient activities classified according to intensity level;', 'determine, based on the one or more stored patient activities, a classification of patient activity intensity level corresponding to the selected level of physical activity simulated by the physics-based model of blood flow through the three-dimensional model ...

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Номер записи: 139
12-03-2015 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20150073722A1
Автор: Choi Gilwoo, Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A computer-implemented method for enabling the assessment of one or more arteries of a patient , based on calculated values of a blood flow characteristic , the method comprising:obtaining a three-dimensional model of at least a portion of one or more arteries of the patient, based on patient-specific imaging data of a geometry of the one or more arteries of the patient;determining a first value of the blood flow characteristic within the one or more arteries of the patient based on the three-dimensional model and a patient-specific model of blood flow through the one or more arteries of the patient;modifying one or both of the three-dimensional model and the patient-specific model of blood flow to reflect an occlusion of the one or more arteries or an opening of an occlusion of the one or more arteries; anddetermining a second value of the blood flow characteristic within the one or more arteries of the patient based on the modified three-dimensional model or the modified patient-specific model of blood flow.186. The computer-implemented method of claim 185 , wherein the blood flow characteristic includes at least one of blood pressure claim 185 , blood velocity claim 185 , blood flow rate claim 185 , or fractional flow reserve within the one or more arteries of the patient.187. The computer-implemented method of ...

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Номер записи: 140
29-05-2014 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20140148693A1
Автор: Taylor Charles A.
Принадлежит: HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patients heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A method for assessing cardiac hemodynamic information , comprising:generating or acquiring anatomic information comprising at least a location and topology of a narrowing of a blood vessel;generating or acquiring blood flow information comprising at least flow information in one or more vessels proximal to the location of the narrowing; andestimating a myocardial fractional flow reserve based at least on the anatomic information and the blood flow information.186. The method of claim 185 , comprising:employing a computed tomography (CT) system to generate a set of CT image data;determining a cardiac phase of interest using the set of CT image data;segmenting the coronary arteries from one or more CT images at the cardiac phase of interest; andderiving the anatomic information based at least on the segmented coronary arteries.187. The method of claim 186 , comprising:employing an ultrasound system to generate a set of ultrasound data; andregistering the ultrasound data based on the cardiac phase of interest.188. The method of claim 185 , comprising:employing a system to generate a set of image data;determining a cardiac phase of interest using the set of image data;segmenting the coronary arteries from one or more reconstructed images at the cardiac phase of interest; andderiving the anatomic information based at ...

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Номер записи: 141
17-03-2016 дата публикации

Method and system for image processing and patient-specific modeling of blood flow

Номер: US20160073991A1
Автор: Charles A. Taylor
Принадлежит: HeartFlow Inc

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 142
15-03-2018 дата публикации

METHOD AND SYSTEM FOR IMAGE PROCESSING TO DETERMINE BLOOD FLOW

Номер: US20180071027A1
Автор: Taylor Charles A.
Принадлежит: HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A medical image diagnostic apparatus for processing medical images , comprising:processing circuitry configured to acquire data of a plurality of Fractional Flow Reserve (FFR) distribution maps comprising at least two time phases regarding a coronary artery; anda display configured to display a representation of the at least one FFR distribution map in phase to the at least one FFR distribution map, wherein the processing circuitry restricts display objects displayed by the display for the representation of the at least one FFR distribution map based on the at least one FFR distribution map.186. The medical image diagnostic apparatus according to claim 185 , wherein the processing circuitry acquires data of a plurality of morphological images comprising the at least two time phases claim 185 , and converts the at least one FFR distribution map into a at least one corresponding color map claim 185 , respectively claim 185 , and the display displays a plurality of superimposed images claim 185 , as the representation of the at least one FFR distribution map claim 185 , obtained by superposing the at least one color map and the plurality of morphological images respectively corresponding in phase.187. The medical image diagnostic apparatus according to claim 186 , wherein the processing circuitry restricts display ...

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Номер записи: 143
11-03-2021 дата публикации

SYSTEMS AND METHODS FOR REPORTING BLOOD FLOW CHARACTERISTICS

Номер: US20210074435A1
Автор: HART Gregory R., Taylor Charles A.
Принадлежит:

Embodiments include a system for displays cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart and create a model representing at least a portion of the patient's heart based on the patient-specific data. The computer system may determine at least one value of the blood flow characteristic within the patient's heart based on the model. The computer system may also display a report comprising a representation of at least one artery corresponding to at least a portion the model, and display one or more indicators of the value of the blood flow characteristic on a corresponding portion of the at least one artery. 120-. (canceled)21. A system for displaying cardiovascular information of a patient , the system comprising:at least one data storage device storing instructions for displaying cardiovascular information of a patient; and ["receive patient-specific data regarding a geometry of the patient's heart;", "create a model representing at least a portion of the patient's heart based on the patient-specific data;", "determine a presence of at least one occlusion in at least one artery of the patient's heart based on the patient-specific data, wherein the at least one artery corresponds to at least a portion of the model;", 'generate a report comprising a representation of the at least one artery based on at least one of the model or the patient-specific data; and', 'display on the report one or more indicators of the at least one occlusion on a corresponding portion of the representation of the at least one artery., 'at least one processor configured to execute the instructions to perform operations comprising22. The system of claim 21 , the operations further comprising:generate a plurality of notifications to a user based on the patient-specific data, wherein at least one of the plurality of notifications comprises an occlusion notification ...

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Номер записи: 144
18-03-2021 дата публикации

SYSTEMS AND METHODS FOR AN INTERACTIVE TOOL FOR DETERMINING AND VISUALIZING A FUNCTIONAL RELATIONSHIP BETWEEN A VASCULAR NETWORK AND PERFUSED TISSUE

Номер: US20210077196A1
Автор: Bai Ying, Grady Leo, JAQUET Clara, SCHAAP Michiel, Taylor Charles A.
Принадлежит:

Systems and methods are disclosed for creating an interactive tool for determining and displaying a functional relationship between a vascular network and an associated perfused tissue. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model, including a tissue region associated with the at least one vessel of the patient; receiving a selected area of the vascular model or a selected area of the tissue model; and generating a display of a region of the tissue model corresponding to the selected area of the vascular model or a display of a portion of the vascular model corresponding to the selected area of the tissue model, respectively. 120-. (canceled)21. A computer-implemented method for displaying information of a functional relationship between a vasculature and a perfused tissue , the method comprising:receiving a patient-specific vascular model of a patient's anatomy;receiving a patient-specific physiological state and at least one boundary condition of the patient-specific vascular model, the at least one boundary condition based on the patient-specific physiological state of the patient;generating a user interface comprising a display of the patient-specific vascular model;receiving, via the user interface, a selection indicating a change in at least one characteristic of the patient-specific physiological state; andupon receiving the selection, displaying, in the user interface an updated version of the patient-specific vascular model based on the changed patient-specific physiological state.22. The computer-implemented method of claim 21 , further comprising:determining a blood supply estimate distribution in the patient-specific vascular model based on the received patient-specific physiological state.23. The computer-implemented method of claim 22 , wherein the blood supply estimate is further determined based on the at least one ...

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Номер записи: 145
05-06-2014 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20140155770A1
Автор: Taylor Charles A.
Принадлежит: HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A system for planning treatment for a patient , the system comprising:at least one computer system configured to:receive patient-specific data regarding a geometry of an anatomical structure of the patient;create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data;determine a first blood flow characteristic within the anatomical structure of the patient based on the three-dimensional model and a physics-based model relating to the anatomical structure of the patient;modify the three-dimensional model; anddetermine a second blood flow characteristic within the anatomical structure of the patient based on the modified three-dimensional model.186. The system of claim 185 , wherein the at least one computer system is further configured to modify the three-dimensional model based on input received from a user claim 185 , the input including a selection of a plan of treatment for the patient.187. The system of claim 186 , wherein:the selected plan of treatment is associated with a change in the geometry of the anatomical structure of the patient; andthe at least one computer system is further configured to modify the three-dimensional model based on the selected plan of treatment.188. The system of claim 187 , wherein:the received input ...

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Номер записи: 146
16-03-2017 дата публикации

SYSTEMS AND METHODS FOR PATIENT-SPECIFIC IMAGING AND MODELING OF DRUG DELIVERY

Номер: US20170076062A1
Автор: Choi Gilwoo, Grady Leo, HUNLEY Stanley C., Taylor Charles A.
Принадлежит:

Systems and methods are disclosed for providing personalized chemotherapy and drug delivery using computational fluid dynamics and medical imaging with machine learning from a vascular anatomical model. One method includes receiving a patient-specific anatomical model of at least one vessel of the patient and a target tissue where a drug is to be supplied; receiving patient-specific information defining the administration of a drug; deriving patient-specific data from the patient specific anatomical model and/or the patient; determining one or more blood flow characteristics in a vascular network leading to the one or more locations in the target tissue where drug delivery data will be estimated or measured, using the patient-specific anatomical model and the patient-specific data; and computing drug delivery data at the one or more locations in the target tissue using transportation, spatial, and/or temporal distribution of the drug particles. 1. A computer-implemented method of estimating drug delivery at a target tissue , the method comprising:receiving a patient-specific anatomical model of at least one vessel of the patient and a target tissue where a drug is to be supplied;receiving patient-specific information defining the administration of a drug;identifying one or more locations in the target tissue where drug delivery data will be estimated or measured;deriving patient-specific data from the patient specific anatomical model and/or the patient;determining one or more blood flow characteristics in a vascular network leading to the one or more locations in the target tissue where drug delivery data will be estimated or measured, using the patient-specific anatomical model and the patient-specific data;determining the transportation, spatial, and/or temporal distribution of the drug particles in one or more locations in the vascular network using the patient-specific information defining the administration of the drug; andcomputing drug delivery data at the ...

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Номер записи: 147
22-03-2018 дата публикации

SYSTEMS AND METHODS FOR MONITORING AND UPDATING BLOOD FLOW CALCULATIONS WITH USER-SPECIFIC ANATOMIC AND PHYSIOLOGIC SENSOR DATA

Номер: US20180078149A1
Автор: Fonte Timothy A., Grady Leo, Taylor Charles A.
Принадлежит: HEARTFLOW, INC.

Systems and methods are disclosed for informing and monitoring blood flow calculations with user-specific activity data, including sensor data. One method includes receiving or accessing a user-specific anatomical model and a first set of physiological characteristics of a user; calculating a first value of a blood flow metric of the user based on the user-specific anatomical model and the first set of physiological characteristics; receiving or calculating a second set of physiological characteristics of the user by accessing or receiving sensor data of the user's blood flow and/or sensor data of the user's physiological characteristics; and calculating second value of the blood flow metric of the user based on the user-specific anatomical model and the second set of physiological characteristics of the user. 1. A computer-implemented method of calculating blood flow metrics using sensor data , the method comprising:receiving or accessing a user-specific anatomical model and a first set of physiological characteristics of a user;calculating a first value of a blood flow metric of the user based on the user-specific anatomical model and the first set of physiological characteristics;receiving or calculating a second set of physiological characteristics of the user by accessing or receiving sensor data of the user's blood flow and/or sensor data of the user's physiological characteristics; andcalculating second value of the blood flow metric of the user based on the user-specific anatomical model and the second set of physiological characteristics of the user.2. The computer-implemented method of claim 1 , further comprising:determining a blood flow model to use to calculate the second value of the blood flow metric; andupdating the blood flow model based on the sensor data.3. The computer-implemented method of claim 2 , wherein the blood flow model is based on a user-specific boundary condition claim 2 , and updating the blood flow model comprises updating the user- ...

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Номер записи: 148
18-03-2021 дата публикации

SYSTEMS AND METHODS FOR ANATOMICAL MODELING USING INFORMATION OBTAINED FROM A MEDICAL PROCEDURE

Номер: US20210082579A1
Автор: Choi Gilwoo, Grady Leo, ROGERS Campbell, Taylor Charles A., Zarins Christopher K.
Принадлежит:

Systems and methods are disclosed herein for anatomical modeling using information obtained during a medical procedure, whereby an initial anatomical model is generated or obtained, a correspondence is determined between the initial model and additional data and/or measurements from an invasive or noninvasive procedure, and, if a discrepancy is found between the initial model and the additional data, the anatomical model is updated to incorporate the additional data and reduce the discrepancy. 120-. (canceled)21. A method of automatically updating a cardiovascular model , comprising:receiving, at at least one processor, a patient-specific anatomical model of at least one cardiovascular vessel and at least one characteristic associated with the patient-specific anatomical model;generating, using the processor, at least one recommendation of an intervention on the patient based on at least one of the patient-specific anatomical model or the at least one associated characteristic;transmitting the at least one recommendation to a display unit;receiving, at the processor, additional patient-specific data from a medical procedure;determining, using the processor, a correspondence and a discrepancy between the additional patient-specific data and at least one of the patient-specific anatomical model or the at least one associated characteristic;modifying, using the processor, at least one of the patient-specific anatomical model or the at least one associated characteristic to reduce the discrepancy;determining, using the processor, an update to the at least one recommendation based on the modified at least one of the patient-specific anatomical model or the at least one associated characteristic, and transmitting the updated at least one recommendation to the display unit.22. The method of claim 21 , wherein:the at least one recommendation includes at least one of a treatment option or an equipment choice; andthe at least one updated recommendation includes a modification ...

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Номер записи: 149
24-03-2016 дата публикации

SYSTEMS AND METHODS FOR TREATMENT PLANNING BASED ON PLAQUE PROGRESSION AND REGRESSION CURVES

Номер: US20160085936A1
Автор: Choi Gilwoo, GRADY Leo J., SANKARAN Sethuraman, SCHAAP Michiel, Taylor Charles A., Zarins Christopher K.
Принадлежит:

Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of a location of disease in the patient's vasculature based on the received patient-specific data; identifying one or more changes in geometry of the anatomic model based on a modeled progression or regression of disease at the location; calculating one or more values of a blood flow characteristic within the patient's vasculature using a computational model based on the identified one or more changes in geometry of the anatomic model; and generating an electronic graphical display of a relationship between the one or more values of the calculated blood flow characteristic and the identified one or more changes in geometry of the anatomic model. 120-. (canceled)21. A computer-implemented method of evaluating a patient with vascular disease , the method comprising:receiving or determining a patient-specific anatomic model representing at least a portion of a location of disease in the patient's vasculature;determining a value of a plaque remodeling characteristic characterizing a propensity of the disease in the patient's vasculature to progress or regress;modeling, using the determined value of the plaque remodeling characteristic, a geometry of the anatomic model at the location of disease at a first point of time;determining a second point of time, the second point of time being associated with a progression or regression of the disease of the modeled geometry since the first point of time based on the determined value of the plaque remodeling characteristic; andgenerating a display updating the modeled geometry of the anatomic model or recommending assessment of the progression or regression of disease at the location of disease at the second point of time.22. The computer-implemented method of claim 21 , wherein the second ...

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Номер записи: 150
26-03-2015 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20150088015A1
Автор: Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patients heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A system for determining cardiovascular information for a patient , the system comprising:at least one computer system configured to execute a method, the method comprising:retrieving data for each of a plurality of patients, the data including an invasively obtained measurement of blood flow characteristic and a blood flow characteristic computed based at least in part on a respective boundary condition; anddetermining boundary conditions tuning characteristics by iteratively comparing computed blood flow characteristics to invasively obtained measurements of blood flow characteristics of each of the patients.186. The system of claim 185 , wherein determining boundary conditions tuning characteristics comprises determining boundary conditions tuning characteristics that tune the respective boundary conditions to reduce a difference between the computed blood flow characteristics and the invasively obtained measurements of blood flow characteristics of each of the patients.187. The system of claim 186 , wherein the data further includes invasively obtained measurements of blood flow characteristics at a plurality of anatomical locations and corresponding computed blood flow characteristics for each of the patients based on at least part on respective boundary condition models at the plurality of anatomical ...

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Номер записи: 151
29-03-2018 дата публикации

Systems and Methods for Image Processing to Determine Blood Flow

Номер: US20180085078A1
Автор: Grady Leo, SANKARAN Sethuraman, Taylor Charles A.
Принадлежит: HEARTFLOW, INC.

Systems and methods are disclosed for assessing a risk of disease. One method includes obtaining an anatomic model associated with a target anatomy; modeling, using a processor, an injection of one or more virtual contrast agents into the anatomic model; performing a simulation of flow of blood and the one or more virtual contrast agents through the anatomic model; and computing one or more characteristics of concentration associated with the one or more virtual contrast agents at one or more locations in the anatomic model based on the simulation. 120-. (canceled)21. A system for processing patient-specific images to determine blood flow , the system comprising:a data storage device storing instructions for processing patient-specific images to determine blood flow; and receiving patient-specific image frames from an imaging system;', 'generating a model of a vasculature system based on the patient-specific image frames, and based on an observed contrast concentration time associated with locations within the model using contrast dye in the vasculature system;', 'determining a computed contrast concentration time associated with the model of the vasculature system using computational fluid dynamics (CFD);', 'adjusting the model of the vasculature system based on a comparison of the observed contrast concentration time and the computed contrast concentration time; and', 'determining a fractional flow reserve (FFR) based on the adjusted model of the vasculature system., 'a processor configured to execute the instruction to perform a method including22. The system as recited in claim 21 , wherein the patient-specific image frames include angiographic images from an x-ray system.23. The system as recited in claim 21 , wherein adjusting the model of the vasculature system comprises adjusting boundary conditions.24. The system as recited in claim 21 , wherein adjusting the model of the vascular system comprises dynamically adjusting a computational analysis of the model ...

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Номер записи: 152
19-03-2020 дата публикации

System and method for diagnosis and assessment of cardiovascular disease by comparing arterial supply capacity to end-organ demand

Номер: US20200085502A1
Автор: Charles A. Taylor, David Spain, Hyun Jin Kim, Nan Xiao, Sethuraman Sankaran, Sophie KHEM
Принадлежит: HeartFlow Inc

Systems and methods are disclosed for to determining a blood supply and blood demand. One method includes receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium; determining a coronary blood supply based on the patient-specific model; determining at least a portion of the myocardium corresponding to the coronary artery; determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; and determining a relationship between the coronary blood supply and the myocardial blood demand.

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Номер записи: 153
29-03-2018 дата публикации

SYSTEMS AND METHODS FOR EMBOLISM PREDICTION USING EMBOLUS SOURCE AND DESTINATION PROBABILITIES

Номер: US20180089384A1
Автор: Choi Gilwoo, Grady Leo, Taylor Charles A., Zarins Christopher K.
Принадлежит:

Systems and methods are disclosed for determining a patient risk assessment or treatment plan based on emboli dislodgement and destination. One method includes receiving a patient-specific anatomic model generated from patient-specific imaging of at least a portion of a patient's vasculature; determining or receiving a location of interest in the patient-specific anatomic model of the patient's vasculature; using a computing processor for calculating blood flow through the patient-specific anatomic model to determine blood flow characteristics through at least the portion of the patient's vasculature of the patient-specific anatomic model downstream from the location of interest; and using a computing processor for particle tracking through the simulated blood flow to determine a destination probability of an embolus originating from the location of interest in the patient-specific anatomic model, based on the determined blood flow characteristics. 120-. (canceled)21. A computer-implemented method of determining a vascular source location of an embolus , the method comprising:receiving a medical condition or disease of interest associated with a patient's vasculature;determining a selected vessel of the patient's vasculature, where the selected vessel is associated with causing the medical condition or disease of interest;determining a probability of an embolus lodging in the selected vessel, where the probability is based on simulating a path of a dislodged embolus through the patient's vasculature; anddetermining a vascular source location of the embolus in the patient's vasculature, based on the determined probability.22. The computer-implemented method of claim 21 , further comprising:receiving a patient-specific anatomic model generated from patient-specific imaging of at least a portion of a patient's vasculature;simulating blood flow through the patient-specific anatomic model; anddetermining, based on the stimulated blood flow, the probability of the embolus ...

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Номер записи: 154
01-04-2021 дата публикации

SYSTEMS AND METHODS FOR ASSESSING ORGAN AND/OR TISSUE TRANSPLANTATION BY SIMULATING ONE OR MORE TRANSPLANT CHARACTERISTICS

Номер: US20210093384A1
Автор: Grady Leo, Taylor Charles A., ZARINS CHRISTOPHER
Принадлежит:

Systems and methods are disclosed for assessing organ and/or tissue transplantation by estimating blood flow through a virtual transplant model by receiving a patient-specific anatomical model of the intended transplant recipient; receiving a patient-specific anatomical model of the intended transplant donor, the model including the vasculature of the organ or tissue that is intended to be transplanted to the recipient; constructing a unified model of the connected system post transplantation, the connected system including the transplanted organ or tissue from the intended transplant donor and the vascular system of the intended transplant recipient; receiving one or more blood flow characteristics of the connected system; assessing the suitability for an actual organ or tissue transplantation using the received blood flow characteristics; and outputting the assessment into an electronic storage medium or display. 120-. (canceled)21. A computer implemented method for assessing organ or tissue transplantation by estimating blood flow through a virtual transplant model , the method comprising:receiving a recipient anatomical model, including a representation of a vasculature of an intended transplant recipient;constructing a geometric model comprising a portion of the recipient anatomical model;estimating blood flow through the geometric model to compute one or more blood flow characteristics;receiving, after a transplant of a tissue or an organ is received by the intended transplant recipient, an updated recipient anatomical model including a vasculature of a portion of the transplanted tissue;updating the geometric model based on the updated recipient anatomical model;estimating an updated blood flow through the updated geometric model;evaluating a risk of an insufficient blood flow to the transplanted tissue or organ using the updated geometric model; andoutputting the evaluation into an electronic storage medium or display.22. The computer implemented method of ...

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Номер записи: 155
06-04-2017 дата публикации

SYSTEM AND METHOD FOR DIAGNOSIS AND ASSESSMENT OF CARDIOVASCULAR DISEASE BY COMPARING ARTERIAL SUPPLY CAPACITY TO END-ORGAN DEMAND

Номер: US20170095292A1
Автор: KHEM Sophie, Kim Hyun Jin, SANKARAN Sethuraman, SPAIN David, Taylor Charles A., XIAO Nan
Принадлежит: HEARTFLOW, INC.

Systems and methods are disclosed for to determining a blood supply and blood demand. One method includes receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium; determining a coronary blood supply based on the patient-specific model; determining at least a portion of the myocardium corresponding to the coronary artery; determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; and determining a relationship between the coronary blood supply and the myocardial blood demand. 1. A computer-implemented method determining a blood supply and a blood demand , the method comprising:receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium;determining a coronary blood supply based on the patient-specific model;determining at least a portion of the myocardium receiving blood from the coronary artery;determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; anddetermining a relationship between the coronary blood supply and the myocardial blood demand.2. The method of claim 1 , further comprising:evaluating the patient based upon the determined relationship between the coronary blood supply and the myocardial blood demand.3. The method of claim 1 , further comprising:determining whether a mismatch exists between the coronary blood supply and the myocardial blood demand based on the determined relationship between the coronary blood supply and the myocardial blood demand.4. The method of claim 3 , further comprising:based on the ...

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Номер записи: 156
28-03-2019 дата публикации

SYSTEMS AND METHODS FOR IDENTIFYING AND MODELING UNRESOLVED VESSELS IN IMAGE-BASED PATIENT-SPECIFIC HEMODYNAMIC MODELS

Номер: US20190095574A1
Автор: Choi Gilwoo, Grady Leo, Kim Hyun Jin, SPAIN David, Taylor Charles A., Tombropoulos Rhea, XIAO Nan
Принадлежит:

Systems and methods are disclosed for identifying and modeling unresolved vessels, and the effects thereof, in image-based patient-specific hemodynamic models. One method includes: receiving, in an electronic storage medium, one or more patient-specific anatomical models representing at least a vessel of a patient; determining, using a processor, the values and characteristics of one or more patient-specific morphometric features in the one or more patient-specific anatomical models; modifying the patient-specific anatomical model using the determined patient-specific morphometric features; and outputting, one or more of, a modified patient-specific anatomical model or a patient-specific morphometric feature to an electronic storage medium or display. 120-. (canceled)21. A computer-implemented method of identifying and modeling the effects of unresolved vessels in image-based patient-specific hemodynamic models , the method comprising:receiving a reference morphometric feature of vessel structure;receiving, in an electronic storage medium, a first patient-specific anatomical model representing at least a vessel of a patient corresponding to the vessel structure;determining, using a processor, a patient-related value of a morphometric feature of the first patient-specific anatomical model; andgenerating an updated patient-specific anatomical model based on a comparison of the determined patient-specific value of the morphometric feature and the reference morphometric feature.22. The computer implemented method of claim 21 , wherein the updated patient-specific anatomical model comprises a truncation or removal of a portion of the first patient-specific anatomical model.23. The computer implemented method of claim 21 , wherein the updated patient-specific anatomical model comprises an extension or addition of a portion of the first patient-specific anatomical model.24. The computer implemented method of claim 21 , wherein the step of determining the patient-related ...

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Номер записи: 157
14-04-2016 дата публикации

METHOD AND SYSTEM FOR SENSITIVITY ANALYSIS IN MODELING BLOOD FLOW CHARACTERISTICS

Номер: US20160103972A1
Автор: GRADY Leo J., SANKARAN Sethuraman, Taylor Charles A.
Принадлежит:

Embodiments include systems and methods for determining cardiovascular information for a patient. A method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of the patient's vasculature based on the patient-specific data; and creating a computational model of a blood flow characteristic based on the anatomic model. The method also includes identifying one or more of an uncertain parameter, an uncertain clinical variable, and an uncertain geometry; modifying a probability model based on one or more of the identified uncertain parameter, uncertain clinical variable, or uncertain geometry; determining a blood flow characteristic within the patient's vasculature based on the anatomic model and the computational model of the blood flow characteristic of the patient's vasculature; and calculating, based on the probability model and the determined blood flow characteristic, a sensitivity of the determined fractional flow reserve to one or more of the identified uncertain parameter, uncertain clinical variable, or uncertain geometry. 1. A system for determining cardiovascular information for a patient , the system comprising: ["create a computational model of a first blood flow characteristic based on an anatomic model, the anatomical model representing at least a portion of the patient's vasculature and being based on based on patient-specific data regarding a geometry of at least the portion of the patient's vasculature;", 'modify a probability model based on one or more of an uncertain parameter, uncertain clinical variable, or uncertain geometry;', "determine a range of a second blood flow characteristic within the patient's vasculature based on a confidence interval and the computational model of the first blood flow characteristic of the patient's vasculature; and", 'calculate, based on the probability model and the determined range of the second blood flow ...

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Номер записи: 158
26-03-2020 дата публикации

METHODS AND SYSTEMS FOR PREDICTING SENSITIVITY OF BLOOD FLOW CALCULATIONS TO CHANGES IN ANATOMICAL GEOMETRY

Номер: US20200098481A1
Автор: Grady Leo, SANKARAN Sethuraman, Taylor Charles A.
Принадлежит:

Embodiments include methods and systems and for determining a sensitivity of a patient's blood flow characteristic to anatomical or geometrical uncertainty. For each of one or more of individuals, a sensitivity of a blood flow characteristic may be obtained for one or more uncertain parameters. An algorithm may be trained based on the sensitivities of the blood flow characteristic and one or more of the uncertain parameters for each of the plurality of individuals. A geometric model, a blood flow characteristic, and one or more of the uncertain parameters of at least part of the patient's vascular system may be obtained for a patient. The sensitivity of the patient's blood flow characteristic to one or more of the uncertain parameters may be calculated by executing the algorithm on the blood flow characteristic of at least part of the patient's vascular system, and one or more of the uncertain parameters. 120-. (canceled)21. A computer-implemented method of determining a sensitivity of a patient's blood flow characteristic to uncertainty in a geometric model of a patient's vascular system , the method comprising:obtaining, for each of a plurality of individuals, a geometric model of at least a portion of a vascular system of each individual and at least one sensitivity of a blood flow characteristic to at least one uncertainty in geometry in the geometric model;mapping, in a machine learning database, a plurality of features of each geometric model to the obtained sensitivities;obtaining a geometric model of at least part of a patient's vascular system;determining, for the patient, at least one value of uncertainty in geometry in the geometric model of at least part of the patient's vascular system; anddetermining a sensitivity of a blood flow characteristic of the patient to at least one value of uncertainty in geometry in the geometric model of at least part of the patient's vascular system, using the machine learning database.22. The method of claim 21 , wherein ...

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Номер записи: 159
21-04-2016 дата публикации

METHOD AND SYSTEM FOR IMAGE PROCESSING TO DETERMINE PATIENT-SPECIFIC BLOOD FLOW CHARACTERISTICS

Номер: US20160110517A1
Автор: Taylor Charles A.
Принадлежит: HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A method for image processing to perform hemodynamic analysis of cerebral vessels , comprising:{'b': '3', 'extracting an anatomical model of a cerebral vessel from D medical image data, the anatomical model of the cerebral vessel including a wall of the cerebral vessel; and'}simulating blood flow in the cerebral vessel and deformation of the cerebral vessel wall using coupled computational fluid dynamics (CFD) and computational solid mechanics (CSM) simulations based on the anatomical model of the cerebral vessel.1863. The method of claim 185 , wherein the step of extracting an anatomical model of a cerebral vessel from D medical image data comprises:{'b': '3', 'detecting a start point and an end point of a vessel segment in the D medical image data;'}extracting a centerline of the cerebral vessel between the start point and the end point;{'b': '2', 'generating a volume by assembling D cross section images extracted along the centerline; and'}segmenting the cerebral vessel wall in the volume.187. The method of claim 186 , wherein the step of extracting a centerline of the cerebral vessel between the start point and the end point comprises:identifying a path between the start point and the end point;segmenting the cerebral vessel based on image intensities along the path; andextracting the centerline of the ...

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Номер записи: 160
21-04-2016 дата публикации

Method and system for image processing to determine patient-specific blood flow characteristics

Номер: US20160110866A1
Автор: Charles A. Taylor
Принадлежит: HeartFlow Inc

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 161
28-04-2016 дата публикации

METHOD AND SYSTEM FOR IMAGE PROCESSING TO DETERMINE PATIENT-SPECIFIC BLOOD FLOW CHARACTERISTICS

Номер: US20160113528A1
Автор: Taylor Charles A.
Принадлежит: HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A method of image processing to perform non-invasive hemodynamic assessment of an aortic stenosis , comprising:estimating patient-specific lumen anatomy of an aorta and a plurality of adjacent vessels from medical image data of a patient;estimating patient-specific aortic blood flow rates from the medical image data of the patient;calculating patient-specific inlet and outlet boundary conditions for a computational model of aortic blood flow based on the patient-specific lumen anatomy, the patient-specific aortic blood flow rates, and non-invasive clinical measurements of the patient; andcomputing aortic blood flow and pressure over the patient-specific lumen anatomy using the computational model of aortic blood flow and the patient-specific inlet and outlet boundary conditions.186. The method of claim 185 , further comprising:calculating a pressure drop across a stenosis region of the aorta using computed pressure values resulting from computing the aortic blood flow and pressure.187. The method of claim 186 , wherein calculating a pressure drop across a stenosis region of the aorta using computed pressure values resulting from computing the aortic blood flow and pressure comprises:calculating a difference between computed pressure values before and after the stenosis region of the aorta based on a computed flow- ...

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Номер записи: 162
28-04-2016 дата публикации

METHOD AND SYSTEM FOR IMAGE PROCESSING TO DETERMINE PATIENT-SPECIFIC BLOOD FLOW CHARACTERISTICS

Номер: US20160113726A1
Автор: Taylor Charles A.
Принадлежит: HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A system for image processing to determine cardiovascular information of a patient , the system comprising: ["receive patient-specific data regarding a geometry of the patient's heart;", "create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data;", "determine a plurality of values of a blood flow characteristic within the patient's heart based on the three-dimensional model;", 'generate an electronic representation of at least one artery corresponding to at least a portion the three-dimensional model; and', 'display, on the electronic representation, one or more indicators of the value of the blood flow characteristic, from the plurality of values, on a corresponding portion of the at least one artery., 'at least one computer system configured to186. The system of claim 185 , wherein the at least one artery is electronically displayed as being colored based upon a value of the blood flow characteristic at one or more locations along the artery.187. The system of claim 185 , wherein the computer system is further configured to:upon determining that the value of the blood flow characteristic exceeds a predetermined threshold, display the value of the blood flow characteristic on a corresponding portion of the at least one artery.188. The system of ...

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Номер записи: 163
28-04-2016 дата публикации

METHOD AND SYSTEM FOR IMAGE PROCESSING TO DETERMINE PATIENT-SPECIFIC BLOOD FLOW CHARACTERISTICS

Номер: US20160117816A1
Автор: Taylor Charles A.
Принадлежит: HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A method of image processing to determine blood flow through coronary arteries of a patient , comprising:receiving a 3D image data set of an anatomy comprising at least one or more coronary arteries and myocardial muscle of the patient;receiving a perfusion information data set corresponding to the 3D image data set;generating an anatomical data set depicting the anatomy based on the 3D image data set;subdividing the myocardial muscle into myocardial muscle segments using a segmentation model based on which portion of the myocardial muscle is supplied by each of the coronary arteries;determining the blood flow into the respective myocardial muscle segments from said perfusion information data set; anddetermining the blood flow into a coronary artery of interest based on the blood flow into all myocardial muscle segments supplied by said coronary artery.186. The method as claimed in claim 185 , wherein said 3D image data sets of at least the coronary arteries and the myocardial muscle is generated from a CT scanner.187. The method as claimed in claim 185 , further comprising the step of using said blood flow into a coronary artery of interest to determine the fractional flow reserve in or along said coronary artery of interest.188. The method as claimed in claim 187 , wherein said fractional flow reserve is ...

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Номер записи: 164
28-04-2016 дата публикации

METHOD AND SYSTEM FOR IMAGE PROCESSING TO DETERMINE PATIENT-SPECIFIC BLOOD FLOW CHARACTERISTICS

Номер: US20160117819A1
Автор: Taylor Charles A.
Принадлежит: HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A medical image processing apparatus , comprising:a first specifier that collates an ischemic region calculated from a blood vessel visualized into a three-dimensional image in a plurality of phases with a dominating region of the blood vessel, and specifies a culprit vessel in the ischemic region;a second specifier that specifies a culprit stenosis in the culprit vessel based on a pressure index calculated from the blood vessel;a determiner that determines a connection position to connect a bypass vessel that makes a detour around the culprit stenosis; anda display controller that displays the determined connection position on a display.186. The medical image processing apparatus of claim 185 , wherein the determiner determines the connection position using the pressure index in the culprit vessel.187. The medical image processing apparatus of claim 186 , wherein the determiner determines a drop level of the pressure index.188. The medical image processing apparatus of claim 186 , wherein the determiner determines the connection position using a measurement of the interior of the culprit vessel.189. The medical image processing apparatus of claim 187 , wherein the determiner determines the connection position using a measurement of the interior of the culprit vessel.190. The medical image processing apparatus of ...

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Номер записи: 165
25-08-2022 дата публикации

SYSTEMS AND METHODS FOR ASSESSING THE SEVERITY OF PLAQUE AND/OR STENOTIC LESIONS USING CONTRAST DISTRIBUTION PREDICTIONS AND MEASUREMENTS

Номер: US20220265239A1
Автор: Grady Leo, Kim Hyun Jin, SANKARAN Sethuraman, Sengupta Souma, Taylor Charles A., XIAO Nan
Принадлежит:

Systems and methods are disclosed for assessing the severity of plaque and/or stenotic lesions using contrast distribution predictions and measurements. One method includes: receiving patient-specific images of a patient's vasculature and a measured distribution of a contrast agent delivered through the patient's vasculature; associating the measured distribution of the contrast agent with a patient-specific anatomic model of the patient's vasculature; defining physiological and boundary conditions of a blood flow model of the patient's blood flow and pressure; simulating the distribution of the contrast agent through the patient-specific anatomic model; comparing the measured distribution of the contrast agent and the simulated distribution of the contrast agent through the patient-specific anatomic model to determine whether a similarity condition is satisfied; and updating the defined physiological and boundary conditions and re-simulating distribution of the contrast agent through the one or more points of the patient-specific anatomic model until the similarity condition is satisfied. 120-. (canceled)21. A computer implemented method for non-invasively estimating blood flow characteristics , the method comprising:receiving information reflecting a measured distribution of a contrast agent delivered through at least a portion of a patient's vasculature;creating a patient-specific measured model indicative of the measured distribution by averaging one or more contrast values over one or more cross sectional areas of a vessel;defining one or more boundary conditions of a blood flow through one or more points of a patient-specific anatomic model of the patient's vasculature;noninvasively generating, using a processor, a patient-specific simulated model of a distribution of the contrast agent through the one or more points of the patient-specific anatomic model using the defined one or more boundary conditions;comparing, using a processor, the patient-specific ...

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Номер записи: 166
05-05-2016 дата публикации

SYSTEMS AND METHODS FOR SIMULATION OF OCCLUDED ARTERIES AND OPTIMIZATION OF OCCLUSION-BASED TREATMENTS

Номер: US20160125154A1
Автор: GRADY Leo J., SANKARAN Sethuraman, Taylor Charles A., Zarins Christopher K.
Принадлежит:

Systems and methods are disclosed for simulation of occluded arteries and/or optimization of occlusion-based treatments. One method includes obtaining a patient-specific anatomic model of a patient's vasculature; obtaining an initial computational model of blood flow through the patient's vasculature based on the patient-specific anatomic model; obtaining a post-treatment computational model by modifying portions of the initial computational model based on an occlusion-based treatment; generating a pre-treatment blood flow characteristic using the initial computational model or computing a post-treatment blood flow using the post-treatment computational model; and outputting a representation of the pre-treatment blood flow characteristic or the post-treatment blood flow characteristic. 1. A computer-implemented method of simulating or optimizing an occlusive procedure , the method comprising:obtaining a patient-specific anatomic model of a patient's vasculature;obtaining an initial computational model of blood flow through the patient's vasculature based on the patient-specific anatomic model;determining an occlusive procedure for treatment of the patient's vasculature;determining one or more outlets, surfaces, or boundaries of the patient's vasculature associated with or created by the occlusive procedure;modifying the initial computational model of blood flow based on the determined one or more outlets, surfaces, or boundaries;modeling redistribution of blood flow based on the occlusive procedure using the modified initial computational model of blood flow;generating a post-treatment blood flow characteristic using the modeled redistribution of blood flow; andoutputting a representation the post-treatment blood flow characteristic.2. The computer-implemented method of claim 1 , wherein the occlusive procedure includes an amputation claim 1 , an embolization therapy claim 1 , or a vascular resection.3. The computer-implemented method of claim 1 , further comprising ...

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Номер записи: 167
05-05-2016 дата публикации

SYSTEMS AND METHODS FOR SIMULATION OF HEMODIALYSIS ACCESS AND OPTIMIZATION

Номер: US20160125161A1
Автор: GRADY Leo J., SANKARAN Sethuraman, Taylor Charles A., Zarins Christopher K.
Принадлежит:

Systems and methods are disclosed for simulating or optimizing hemodialysis access. One method includes receiving a patient-specific anatomic model of a patient's vasculature; computing a pre-treatment hemodynamic characteristic of a pre-treatment geometry of a portion of the anatomic model; simulating a post-treatment geometry of a vascular access in the portion of the anatomic model; computing a post-treatment hemodynamic characteristic of the post-treatment geometry of the portion of the anatomic model having the vascular access; and generating a representation of the pre-treatment hemodynamic characteristic or the post-treatment hemodynamic characteristic. 1. A computer-implemented method of simulating or optimizing hemodialysis access , the method comprising:receiving a patient-specific, three-dimensional anatomic model of a patient's vasculature;computing a pre-treatment hemodynamic characteristic of a pre-treatment geometry of a portion of the received three-dimensional anatomic model;modifying the geometry of the received three-dimensional anatomic model as having a post-treatment geometry of a vascular access in the portion of the received three-dimensional anatomic model, the post-treatment geometry being different from the pre-treatment geometry of the portion of the received three-dimensional anatomic model;determining a computational model for computing a hemodynamic characteristic of the modified three-dimensional anatomic model having the post-treatment geometry of the vascular access;computing a post-treatment hemodynamic characteristic using the computational model associated with the modified three-dimensional anatomic model; andgenerating a representation of the post-treatment hemodynamic characteristic.2. The computer-implemented method of claim 1 , wherein the hemodynamic characteristic includes blood pressure claim 1 , blood velocity claim 1 , or cardiac output.3. The computer-implemented method of claim 1 , further comprising:receiving or ...

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Номер записи: 168
27-05-2021 дата публикации

METHOD AND SYSTEM FOR PROCESSING ELECTRONIC IMAGES FOR BOUNDARY CONDITION OPTIMIZATION

Номер: US20210153749A1
Автор: Fonte Timothy A., KHEM Sophia, Kim Hyun Jin, Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1. A system for determining cardiovascular information for a patient , the system comprising: retrieving data for each of a plurality of patients, the data including an invasively obtained measurement of blood flow characteristic and a blood flow characteristic computed based at least in part on a respective boundary condition; and', 'determining boundary conditions tuning characteristics by iteratively comparing computed blood flow characteristics to invasively obtained measurements of blood flow characteristics of each of the patients., 'at least one computer system configured to execute a method, the method comprising2. The system of claim 1 , wherein determining boundary conditions tuning characteristics comprises determining boundary conditions tuning characteristics that tune the respective boundary conditions to reduce a difference between the computed blood flow characteristics and the invasively obtained measurements of blood flow characteristics of each of the patients.3. The system of claim 2 , wherein the data further includes invasively obtained measurements of blood flow characteristics at a plurality of anatomical locations and corresponding computed blood flow characteristics for each of the patients based on at least part on respective boundary condition models at the plurality of anatomical locations.4. The system of ...

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Номер записи: 169
27-05-2021 дата публикации

SYSTEMS AND METHODS FOR PREDICTING CORONARY PLAQUE VULNERABILITY FROM PATIENT SPECIFIC ANATOMIC IMAGE DATA

Номер: US20210153945A1
Автор: Choi Gilwoo, Grady Leo, SCHAAP Michiel, Taylor Charles A.
Принадлежит:

Systems and methods are disclosed for predicting coronary plaque vulnerability, using a computer system. One method includes acquiring anatomical image data of at least part the patient's vascular system; performing, using a processor, one or more image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical image data; predicting, using the processor, a coronary plaque vulnerability present in the patient's vascular system, wherein predicting the coronary plaque vulnerability includes calculating an adverse plaque characteristic based on results of the one or more of image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis of the anatomical image data; and reporting, using the processor, the calculated adverse plaque characteristic. 120-. (canceled)21. A computer-implemented method of reporting coronary plaque vulnerability from patient-specific anatomic image data , the method comprising:acquiring, via a processor, anatomical image data of at least part of a patient's vascular system; extracting, using the processor, a geometric feature of a vessel or plaque from the anatomical image data or a personalized modeling of the vessel and/or plaque based on the anatomical image data;', 'obtaining a hemodynamic feature of the patient from a hemodynamic sensor or the personalized modeling of the vessel and/or plaque;', 'obtaining a biochemical feature of the plaque from test data associated with a blood test of the patient or the personalized modeling of the vessel and/or plaque; and', 'determining, using the processor, a feature vector including a numerical description of the geometric feature, the hemodynamic feature, and the biochemical feature; and, "for each of one or more locations of the patient's vascular system:"}predicting, using the processor, a plaque vulnerability present in the patient's vascular system ...

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Номер записи: 170
12-05-2016 дата публикации

METHOD AND SYSTEM FOR IMAGE PROCESSING TO DETERMINE PATIENT-SPECIFIC BLOOD FLOW CHARACTERISTICS

Номер: US20160128661A1
Автор: Taylor Charles A.
Принадлежит: HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A method for image analysis to perform vascular assessment during a session of vascular catheterization of a subject , the method comprising:receiving a plurality of angiographic images imaging a portion of the vasculature of the subject, wherein the portion of the vasculature comprises a stenosis, and wherein the plurality of angiographic images was obtained during the session;producing, by automatic processing of the angiographic images, a first vascular tree model modeling the portion of the vasculature; anddetermining automatically, based on said first vascular tree model, an improvement value quantifying a capacity for restoration of flow by opening the stenosis;wherein the receiving, producing and determining are performed while the subject remains in the session and catheterized.186. The method of claim 185 , wherein the improvement value comprises calculations based on change of a vascular width.187. The method of claim 185 , wherein said determining automatically and said automatic processing comprise formation of a static perfusion model.188. The method of claim 185 , wherein said determining automatically comprises linear modeling of vascular flow characteristics.189. The method of claim 185 , wherein said first vascular tree model comprises vascular center lines and vascular widths therealong.190. The ...

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Номер записи: 171
12-05-2016 дата публикации

Method and system for image processing to determine patient-specific blood flow characteristics

Номер: US20160133015A1
Автор: Charles A. Taylor
Принадлежит: HeartFlow Inc

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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Номер записи: 172
03-06-2021 дата публикации

SYSTEM AND METHODS FOR ESTIMATION OF BLOOD FLOW CHARACTERISTICS USING REDUCED ORDER MODEL AND MACHINE LEARNING

Номер: US20210161384A1
Автор: Grady Leo, KIM Jin, Sanders Travis Michael, SANKARAN Sethuraman, SPAIN David, Taylor Charles A., XIAO Nan
Принадлежит:

Systems and methods are disclosed for determining blood flow characteristics of a patient. One method includes: receiving, in an electronic storage medium, patient-specific image data of at least a portion of vasculature of the patient having geometric features at one or more points; generating a patient-specific reduced order model from the received image data, the patient-specific reduced order model comprising estimates of impedance values and a simplification of the geometric features at the one or more points of the vasculature of the patient; creating a feature vector comprising the estimates of impedance values and geometric features for each of the one or more points of the patient-specific reduced order model; and determining blood flow characteristics at the one or more points of the patient-specific reduced order model using a machine learning algorithm trained to predict blood flow characteristics based on the created feature vectors at the one or more points. 120-. (canceled)21. A computer-implemented method of determining blood flow characteristics of a patient , the method comprising:receiving, in an electronic storage medium, a patient-specific anatomical model of at least a portion of the patient's vasculature including geometric features at one or more points;truncating the patient-specific anatomical model at locations of the patient-specific anatomical model for which blood flow characteristics are to be determined;applying boundary conditions to the truncated patient-specific anatomical model, the boundary conditions associated with hemodynamics at an inflow of blood flow, outflow of blood flow, and a vessel wall of the truncated patient-specific anatomic model;using the boundary conditions to estimate a first value for the blood flow characteristic at one or more locations of the truncated patient-specific anatomic model;generating a reduced-order model that is representative of the truncated patient-specific anatomic model, the reduced-order ...

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Номер записи: 173
11-05-2017 дата публикации

SYSTEMS AND METHODS FOR ANATOMICAL MODELING USING INFORMATION OBTAINED FROM A MEDICAL PROCEDURE

Номер: US20170132388A1
Автор: Choi Gilwoo, Grady Leo, ROGERS Campbell, Taylor Charles A., Zarins Christopher K.
Принадлежит:

Systems and methods are disclosed herein for anatomical modeling using information obtained during a medical procedure, whereby an initial anatomical model is generated or obtained, a correspondence is determined between the initial model and additional data and/or measurements from an invasive or noninvasive procedure, and, if a discrepancy is found between the initial model and the additional data, the anatomical model is updated to incorporate the additional data and reduce the discrepancy. 1. A method of automatically updating a cardiovascular model , comprising:receiving, at a processor, a patient-specific, three-dimensional anatomical model of at least one cardiovascular vessel;receiving, at the processor, at least one characteristic associated with the three-dimensional anatomical model;using the processor to transmit a representation of at least one of the three-dimensional anatomical model or the at least one associated characteristic to a display unit;receiving, at the processor, additional patient-specific data relating to the three-dimensional anatomical model from a medical procedure;using the processor to determine a correspondence between the additional patient-specific data and at least one of the three-dimensional anatomical model or the at least one associated characteristic;using the processor to identify a discrepancy between the additional patient-specific data and at least one of the three-dimensional anatomical model or the at least one associated characteristic;using the processor to modify at least one of the three-dimensional anatomical model or the at least one associated characteristic to reduce the discrepancy; andusing the processor to transmit an updated representation of at least one of the three-dimensional anatomical model or the at least one associated characteristic to the display unit.2. The method of claim 1 , further comprising:using the processor to model an intervention or a part thereof on the anatomical model; andusing the ...

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Номер записи: 174
19-05-2016 дата публикации

METHOD AND SYSTEM FOR IMAGE PROCESSING TO DETERMINE PATIENT-SPECIFIC BLOOD FLOW CHARACTERISTICS

Номер: US20160140313A1
Автор: Taylor Charles A.
Принадлежит: HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A device for using image processing to determine a perfusion of a myocardial muscle comprising:a first simulation unit to simulate a blood flow through coronary blood vessels on the basis of segmented coronary blood vessels from a static coronary computed tomography angiography (CCTA) image, and to determine the blood flow into different regions of the myocardial muscle into which different branches of the coronary blood vessels lead; anda second simulation unit to simulate a local perfusion of the myocardial muscle for the different regions on the basis of the determined blood flow into the different regions of the myocardial muscle.186. The device as claimed in claim 185 , wherein the first simulation unit is configured to calculate a model of the coronary blood vessels and of the myocardial muscle on the basis of the segmented coronary blood vessels and of a left myocardial muscle and to perform the simulation of the blood flow with the aid of the model.187. The device as claimed in claim 185 , wherein the first simulation unit is configured to simulate the blood flow through the coronary blood vessels on the basis of the segmented coronary blood vessels using a lattice Boltzmann method.188. The device as claimed in claim 185 , wherein the first simulation unit is configured to use a statistical model to ...

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Номер записи: 175
09-05-2019 дата публикации

SYSTEMS AND METHODS FOR DETERMINATION OF BLOOD FLOW CHARACTERISTICS AND PATHOLOGIES THROUGH MODELING OF MYOCARDIAL BLOOD SUPPLY

Номер: US20190133456A1
Автор: Grady Leo, Taylor Charles A.
Принадлежит:

Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving one or more vascular models associated with either the patient or with a plurality of individuals; receiving observed perfusion information associated with the patient; and estimating, using one or more computer processors, one or more blood flow characteristics or one or more pathological characteristics of the patient based on the observed perfusion information and the one or more vascular models. 120-. (canceled)21. A computer-implemented method of generating a patient-specific perfusion treatment recommendation , the method comprising:receiving a vascular model associated with one or more individuals;receiving a tissue model associated with the one or more individuals;generating an expected perfusion map using the received vascular model and the received tissue model;receiving, for a given patient, a patient-specific observed perfusion value; andgenerating a treatment recommendation based on the expected perfusion map and the patient-specific observed perfusion value.22. The computer-implemented method of claim 21 , wherein the expected perfusion map includes a vascular pathology corresponding to a perfusion value.23. The computer-implemented method of claim 21 , further comprising:calculating a first perfusion value using the vascular model and the tissue model;determining, using a fluid dynamics computation, a first vascular pathology of the vascular model used for the calculation of the first perfusion value; andgenerating the expected perfusion map from the first vascular pathology and the calculated first perfusion value.24. The computer-implemented method of claim 21 , further comprising:deforming a stored vascular model based on the expected perfusion map and the received patient-specific observed perfusion value;generating a patient-specific vascular model based on the deformed vascular model; andgenerating the treatment recommendation based on ...

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Номер записи: 176
07-08-2014 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20140222406A1
Автор: Taylor Charles A.
Принадлежит: HEARTFLOW, INC.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A system for determining cardiovascular information for a patient , the system comprising: receive patient-specific data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of a plurality of coronary arteries emanating from an aorta;', 'create a three-dimensional model representing a first portion of the anatomical structure based on the patient-specific data, the first portion of the anatomical structure including at least the portion of the plurality of coronary arteries;', 'create a physics-based model of the first portion of the anatomical structure based on, at least in part, a mass or a volume of myocardial tissue; and', 'determine at least one blood flow characteristic within the first portion of the anatomical structure based on the three-dimensional model and the physics-based model., 'at least one computer system configured to186. The system of claim 185 , wherein:the at least one blood flow characteristic is chosen from blood velocity, blood pressure, and blood flow rate; andthe at least one computer system is configured to determine the at least one blood flow characteristic at a plurality of locations in the plurality of coronary arteries.187. The system of claim 185 , wherein the patient-specific data includes imaging data.188. The ...

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Номер записи: 177
24-05-2018 дата публикации

METHOD AND SYSTEM FOR MODELING BLOOD FLOW WITH BOUNDARY CONDITIONS FOR OPTIMIZED DIAGNOSTIC PERFORMANCE

Номер: US20180140258A1
Автор: Fonte Timothy A., KHEM Sophie, Kim Hyun Jin, Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 131-. (canceled)32. A system for modeling blood flow for a patient , the system comprising at least one computer system configured to execute a method , the method comprising:tuning a boundary condition function parameter value for each individual in a tuning population;testing the tuned boundary condition function parameter value for each individual in a testing population different from the tuning population;generating a patient-specific anatomical model representing at least a portion of anatomy of a patient not in the tuning population or the testing population;using the tuned, tested, boundary condition function parameter value and the generated patient-specific anatomical model to compute a patient-specific blood flow characteristic value for the patient not in either the tuning population or the testing population; andoutputting the generated patient-specific anatomical model and the computed patient-specific blood flow characteristic value.33. The system of claim 32 , wherein the system is further configured for: retrieving, using at least one processor, an invasively obtained blood flow characteristic value of the individual in the tuning population;', 'non-invasively computing, using at least one processor, a blood flow characteristic value based at least in part on the boundary condition function parameter value;', ' ...

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Номер записи: 178
04-06-2015 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20150150530A1
Автор: Taylor Charles A., Zarins Christopher K.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A system for determining blood flow information for a patient , the system comprising: ["receive patient-specific imaging data regarding a geometry of the patient's vasculature, including at least a portion of the patient's vasculature beyond the patient's coronary arteries;", "create a three-dimensional model representing at least the portion of the patient's vasculature based on the patient-specific imaging data;", "create a physics-based model relating to a blood flow characteristic of blood flow through the portion of the patient's vasculature; and", "determine a blood flow characteristic within the patient's vasculature using the three-dimensional model and the physics-based model."], 'at least one computer system configured to186. The system of claim 185 , wherein the portion of the patient's vasculature beyond the patient's coronary arteries includes the patient's peripheral vasculature.187. The system of claim 185 , wherein the portion of the patient's vasculature of beyond the patient's coronary arteries includes at least one of a portion of a plurality of arteries in the patient's heart claim 185 , neck claim 185 , head claim 185 , thorax claim 185 , abdomen claim 185 , arms claim 185 , or legs.188. The system of claim 185 , wherein:the determined blood flow characteristic includes a ratio between a ...

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Номер записи: 179
30-04-2020 дата публикации

SYSTEMS AND METHODS FOR EMBOLISM PREDICTION USING EMBOLUS SOURCE AND DESTINATION PROBABILITIES

Номер: US20200135338A1
Автор: Choi Gilwoo, Grady Leo, Taylor Charles A., Zarins Christopher K.
Принадлежит:

Systems and methods are disclosed for determining a patient risk assessment or treatment plan based on emboli dislodgement and destination. One method includes receiving a patient-specific anatomic model generated from patient-specific imaging of at least a portion of a patient's vasculature; determining or receiving a location of interest in the patient-specific anatomic model of the patient's vasculature; using a computing processor for calculating blood flow through the patient-specific anatomic model to determine blood flow characteristics through at least the portion of the patient's vasculature of the patient-specific anatomic model downstream from the location of interest; and using a computing processor for particle tracking through the simulated blood flow to determine a destination probability of an embolus originating from the location of interest in the patient-specific anatomic model, based on the determined blood flow characteristics. 120-. (canceled)21. A computer-implemented method of determining a patient risk assessment or treatment plan based on emboli dislodgement and destination , the method comprising:receiving a patient-specific anatomic model generated from patient-specific imaging of at least a portion of a patient's vasculature;determining or receiving a location of interest in the patient-specific anatomic model of the patient's vasculature;computing, using a computing processor, a blood flow characteristic of blood flow through at least the portion of the patient-specific anatomic model downstream from the location of interest;determining, using the computing processor, a velocity field of the computed blood flow; andcomputing, using the computing processor, a destination probability of an embolus originating from the location of interest in the patient-specific anatomic model, based on the computed blood flow and the determined velocity field; andcomputing, using the computing processor, a likelihood of the location of interest being an ...

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Номер записи: 180
16-05-2019 дата публикации

SYSTEMS AND METHODS FOR DETERMINATION OF BLOOD FLOW CHARACTERISTICS AND PATHOLOGIES THROUGH MODELING OF MYOCARDIAL BLOOD SUPPLY

Номер: US20190142281A1
Автор: Grady Leo, Taylor Charles A.
Принадлежит:

Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving one or more vascular models associated with either the patient or with a plurality of individuals; receiving observed perfusion information associated with the patient; and estimating, using one or more computer processors, one or more blood flow characteristics or one or more pathological characteristics of the patient based on the observed perfusion information and the one or more vascular models. 120-. (canceled)21. A computer-implemented method of generating a patient-specific perfusion treatment recommendation , the method comprising:receiving a vascular model associated with one or more individuals;receiving a tissue model associated with the one or more individuals;generating an expected perfusion map using the received vascular model and the received tissue model;receiving, for a given patient, a patient-specific observed perfusion value; andgenerating a treatment recommendation based on the expected perfusion map and the patient-specific observed perfusion value.22. The computer-implemented method of claim 21 , wherein the expected perfusion map includes a vascular pathology corresponding to a perfusion value.23. The computer-implemented method of claim 21 , further comprising:calculating a first perfusion value using the vascular model and the tissue model;determining, using a fluid dynamics computation, a first vascular pathology of the vascular model used for the calculation of the first perfusion value; andgenerating the expected perfusion map from the first vascular pathology and the calculated first perfusion value.24. The computer-implemented method of claim 21 , further comprising:deforming a stored vascular model based on the expected perfusion map and the received patient-specific observed perfusion value;generating a patient-specific vascular model based on the deformed vascular model; andgenerating the treatment recommendation based on ...

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Номер записи: 181
25-05-2017 дата публикации

SYSTEMS AND METHODS FOR SIMULATION OF OCCLUDED ARTERIES AND OPTIMIZATION OF OCCLUSION-BASED TREATMENTS

Номер: US20170147780A1
Автор: Grady Leo, SANKARAN Sethuraman, Taylor Charles A., Zarins Christopher K.
Принадлежит:

Systems and methods are disclosed for simulation of occluded arteries and/or optimization of occlusion-based treatments. One method includes obtaining a patient-specific anatomic model of a patient's vasculature; obtaining an initial computational model of blood flow through the patient's vasculature based on the patient-specific anatomic model; obtaining a post-treatment computational model by modifying portions of the initial computational model based on an occlusion-based treatment; generating a pre-treatment blood flow characteristic using the initial computational model or computing a post-treatment blood flow using the post-treatment computational model; and outputting a representation of the pre-treatment blood flow characteristic or the post-treatment blood flow characteristic. 120-. (canceled)21. A computer-implemented method simulating or optimizing an occlusive procedure , the method comprising:obtaining a patient-specific anatomic model of a patient's vasculature;obtaining an initial computational model of blood flow through the patient's vasculature based on the patient-specific anatomic model, the initial computational model including a pre-treatment boundary condition;determining a pre-treatment blood flow characteristic value by performing a calculation of blood flow using the initial computational model;updating the initial computational model based on a post-treatment boundary condition associated with an occlusive procedure;determining a post-treatment blood flow characteristic value by performing a calculation of blood flow using the updated computational model; andgenerating a treatment recommendation based on a comparison of the pre-treatment blood flow characteristic and the post-treatment blood flow characteristic.22. The computer-implemented method of claim 21 , wherein the calculation of blood flow includes Navier-Stokes equations claim 21 , reduced order models claim 21 , or machine learning methods.23. The computer-implemented method of ...

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Номер записи: 182
02-06-2016 дата публикации

SYSTEMS AND METHODS FOR VESSEL REACTIVITY TO GUIDE DIAGNOSIS OR TREATMENT OF CARDIOVASCULAR DISEASE

Номер: US20160154944A1
Автор: GRADY Leo J., Taylor Charles A., Zarins Christopher K.
Принадлежит:

Systems and methods are disclosed for using vessel reactivity to guide diagnosis or treatment for cardiovascular disease. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; determining, by measurement or estimation, a first vessel size at one or more locations of a vessel of the patient-specific vascular model at a first physiological state; determining a second vessel size at the one or more locations of the vessel of the patient-specific vascular model at a second physiological state using a simulation or learned information; comparing the first vessel size to the corresponding second vessel size; and estimating a characteristic of the vessel of the patient-specific vascular model based on the comparison. 120-. (canceled)21. A computer-implemented method of using vessel reactivity in diagnosing or treating disease , the method comprising:receiving image data of one or more blood vessels of a patient, the image data being obtained while the patient's body is at a first physiological state;determining a patient-specific biomechanical model of the one or more blood vessels from the image data obtained while the patient's body is at the first physiological state;determining a mechanical response of the vessel wall associated with a second physiological state, the mechanical response of the vessel wall including a response to pressure on the vessel wall or a response to medication;updating the patient-specific biomechanical model of the one or more blood vessels based on the determined mechanical response; anddetermining a blood flow characteristic through the one or more blood vessels of the patient based on the updated patient-specific biomechanical model.22. The computer-implemented method of claim 21 , further comprising:determining a first vessel resistance at a location in a blood vessel of the one or more blood vessels at the first physiological state;determining a second vessel ...

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Номер записи: 183
11-06-2015 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20150161326A1
Автор: Bai Ying, Fonte Timothy A., Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A computer-implemented method for determining patient-specific cardiovascular information using at least one computer system , the method comprising:receiving, at the at least one computer system, a patient-specific geometric model of at least a portion of a coronary artery and at least a portion of myocardial tissue connected to the portion of the coronary artery of the patient;simulating perfusion through at least the portion of the myocardial tissue based on the patient-specific geometric model, using the at least one computer system;receiving, at the at least one computer system, a patient-specific measure of perfusion through at least the portion of the myocardial tissue of the patient;comparing, using the at least one computer system, the simulated perfusion to the patient-specific measure of perfusion through the portion of the myocardial tissue; andmodifying a parameter or geometry of the patient-specific geometric model if the simulated perfusion is outside a predetermined threshold from the patient-specific measure of perfusion through the portion of the myocardial tissue of the patient.186. The method of claim 185 , further comprising:extending, using the at least one computer system, the patient-specific geometric model to form an augmented model by extending at least one of the coronary arteries ...

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Номер записи: 184
11-06-2015 дата публикации

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Номер: US20150161348A1
Автор: Bai Ying, Fonte Timothy A., Taylor Charles A.
Принадлежит:

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A computer-implemented method for determining patient-specific hemodynamic information using at least one computer system , the method comprising:receiving, at the at least one computer system, a patient-specific geometric model of at least a portion of the patient's vasculature and at least a portion of tissue connected to the portion of the patient's vasculature;determining, using the at least one computer system, one or more values of a blood flow characteristic within one or more vessels in the portion of the patient's vasculature or the portion of tissue based on a simulation of blood flow through the patient-specific geometric model;determining, using the at least one computer system, a perfusion risk index within at least the portion of the tissue based on the patient-specific geometric model and the one or more calculated values of the blood flow characteristic; andstoring a visual representation of the determined perfusion risk index on a representation of the patient-specific geometric model, using the computer system.186. The method of claim 185 , further comprising:extending, using the at least one computer system, the patient-specific geometric model to form an augmented model by extending at least one vessel of the portion of the patient's vasculature; andassociating the perfusion risk index with one ...

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Номер записи: 185