Способ оценки состояния гуморального гомеостаза у онкологических больных

Apparatus and method for identifying the control a predetermined body part by a subject willentlichen

Die Erfindung betrifft eine Trainings- und Stimulationsanordnung (10) zum Erlernen der willentlichen Steuerung eines vorgegebenen Körperteils (11) durch einen Probanden (1) umfassend - eine Elektrodenhaube (2), die eine Anzahl von Elektroden (21) aufweist, - eine der Elektrodenhaube (2) nachgeschaltete Auswerteeinheit (3), die dazu ausgebildet ist, die an den Elektroden (21) anliegenden Spannungen zu messen und als EEG-Messdaten zur Verfügung zu stellen, wobei die Auswerteeinheit (3) dazu ausgebildet ist, die EEG-Messdaten auf das Vorliegen einer gedanklichen Tätigkeit zu analysieren und einen Übereinstimmungswert zu ermitteln, - eine Steuereinheit (4), der der Ausgang der Auswerteeinheit (3) zugeführt ist und - zumindest eine der Steuereinheit (4) nachgeschaltete Stimulationseinheit (5a). Erfindungsgemäß ist vorgesehen, dass die Steuereinheit (4) dazu ausgebildet ist, - die Stimulationseinheit (5a) anzusteuern, einen Hinweisstimulus auf den Körperteil (11) des Probanden (1) zu applizieren ...

Apparatus and method for identifying the control a predetermined body part by a subject willentlichen

Die Erfindung betrifft eine Trainings- und Stimulationsanordnung (10) zum Erlernen der willentlichen Steuerung eines vorgegebenen Körperteils (11) durch einen Probanden (1) umfassend - eine Elektrodenhaube (2), die eine Anzahl von Elektroden (21) aufweist, - eine der Elektrodenhaube (2) nachgeschaltete Auswerteeinheit (3), die dazu ausgebildet ist, die an den Elektroden (21) anliegenden Spannungen zu messen und als EEG-Messdaten zur Verfügung zu stellen, wobei die Auswerteeinheit (3) dazu ausgebildet ist, die EEG-Messdaten auf das Vorliegen einer gedanklichen Tätigkeit zu analysieren und einen Übereinstimmungswert zu ermitteln, - eine Steuereinheit (4), der der Ausgang der Auswerteeinheit (3) zugeführt ist und - zumindest eine der Steuereinheit (4) nachgeschaltete Stimulationseinheit (5a). Erfindungsgemäß ist vorgesehen, dass die Steuereinheit (4) dazu ausgebildet ist, - die Stimulationseinheit (5a) anzusteuern, einen Hinweisstimulus auf den Körperteil (11) des Probanden (1) zu applizieren ...

Heat beam dolorimeter

DEVICE AND METHOD FOR ASSESSING THERMOALGESIC AND VIBRATORY SENSITIVITY

The invention relates to a device for assessing thermoalgesic and vibratory sensitivity, including a first unit (1) configured to apply, to localised points of the patient, a plurality of stimuli comprising vibrations and temperature changes, a second unit (2) for gathering data communicating with the first unit, wherein the communication between the first unit (1) and the second unit (2) takes place by means of a two-way wireless transmission means. The invention also relates to a method for assessing vibratory, thermal and thermoalgesic sensitivity using the device according to the invention.

DEVICE AND METHOD FOR ASSESSING THERMOALGESIC AND VIBRATORY SENSITIVITY

The invention relates to a device for assessing thermoalgesic and vibratory sensitivity, including a first unit (1) configured to apply, to localised points of the patient, a plurality of stimuli comprising vibrations and temperature changes, a second unit (2) for gathering data communicating with the first unit, wherein the communication between the first unit (1) and the second unit (2) takes place by means of a two-way wireless transmission means. The invention also relates to a method for assessing vibratory, thermal and thermoalgesic sensitivity using the device according to the invention.

HOT AND COLD SENSOR DISCRIMINATION UNIT

A hot and cold sensor discrimination unit having an insulated liquid-filled container with a temperature indicator and a metal probe with a temperature indicator for use in perception of temperature by a patient. ? * * * ...

HEAT BEAM DOLORIMETER

A portable dolorimeter arrangement for determining a subject's cutaneous pain tolerance level at any site on the body allows for chronic pain diagnosis, and for the diagnosis of subtle sensory abnormalities. The arrangement comprises a heat projector (9) and an IR thermopile (19) focused on the same area of the subject's skin. The heat projector (9) is controlled via an interface (20) by a lap top computer (4) which performs acquisition, processing, display and storage of pain tolerance latency data.

DEVICE IN ORDER TO CARRY OUT DIAGNOSTIC TESTS OF THE SENSIBILITY TO THE THERMAL STIMULI.

Apparatus for the quantitative measurement of thermal perception at the individual

IN AN APPARATUS FOR TESTING SURFACE SUSCEPTIBILITIES

Comprehensive pain assessment systems and methods

Systems, devices, and methods are provided for simultaneous assessment of a subject's subjective and objective pain states. These include a dolorimeter arrangement for determining a subject's cutaneous pain tolerance level at any site on the body. In certain preferred embodiments, the dolorimeter is hand-held and utilizes a sonar distance-measuring device. In another aspect, the systems, devices, and methods of the current invention include platforms effective for implementing pain monitoring methods that include delivering pain questionnaires to patients over a period of time points. The platforms may harvest analgesic drug data from nurses attending the patients, and may provide simple statistical analysis of collected data useful both at the bedside and at central base-stations. The platforms may provide additional functions based on analysis of patient pain data. Preferred embodiments of the current invention combine the dolorimeter arrangement with the platforms for implementing pain ...

DIAGNOSTICS EQUIPMENT FOR THE DETERMINATION OF THE TEMPERATURE SENSITIVITY.

Apparatus and methods for testing pain sensitivity

Sonar-controlled apparatus for the delivery of electromagnetic radiation

A NON-INVASIVE, QUANTITATIVE SOMATOSENSORY METHOD FOR THE EVALUATION OF ERECTILE DYSFUNCTION

Configurable system for evaluating stimulus sensitivity of a subject and method of use therefor

A configurable system is used to evaluate stimulus sensitivity of a subject. An action channel provides a stimulus to the subject and a reaction channel receives a response from the subject. A signal pathway is connected to the action channel and to the reaction channel. A controller establishes loops within the signal pathway. Loop types include a transduction loop including the action channel and forming a path terminating in the signal pathway, and a channel loop including the action channel and terminating at a reference unit. Other possible loop types include an interface loop including the action channel, the reaction channel and the reference unit having an initial parameter value, and an adaptive loop including the action channel, the reaction channel and the reference unit whose parameter value is adapted based on the response from the subject. A method using the system is also described.

SYSTEM AND METHOD FOR PAIN DETECTION AND COMPUTATION OF A PAIN QUANTIFICATION INDEX

A method of detecting pain in subject comprises of generating brain wave data based on brain wave activity of subject and comparing the brain wave data to reference data to generate result data. The reference data corresponds to (i) population normative data indicative of brain wave activity of first plurality of individuals in an absence of pain, (ii) population reference data indicative of brain wave activity of second plurality of individuals generated in response to pain events inflicted on second plurality of individuals, (iii) subjective population reference data indicative of brain wave activity of third plurality of individuals reporting a sensation of pain, and/or (iv) population of reference data indicative of brain wave activity of fourth population of individuals following an intervention which has changed a subjective report of pain in combination with determining a presence of pain experienced by subject as a function of the result data.

DEVICE TO TEST the THERMAL SENSITIVITY Of a PATIENT

Способ оценки состояния гуморального гомеостаза у онкологических больных

Изобретение относится к средствам исследования физических свойств биологических тканей. Способ исследования гуморального гомеостаза у онкологических больных включает выделение зондирующими и измерительными электродами локальных зон исследования организма человека, после чего на измерительных электродах в зоне исследования задают выбранную частоту в диапазоне от 800 Гц до 1,2 МГц и значение величины зондирующего тока от 0,8 до 1,5 мA, при этом исследование проводят при различных значениях частоты ƒ, но при постоянном значении выбранного зондирующего тока i. Затем определяют потенциал напряжения U между измерительными электродами в виде соотношения U=i(R+jωL-j/ωC), где R - активная составляющая сопротивления, L - индуктивность биологической ткани, С - емкость биологической ткани, ω=2πƒ сек- круговая частота,, после чего по произведению величины выбранного зондирующего тока и соответственно активному, индуктивному и емкостному составляющим сопротивления определяют распределение электрических ...

КОНФИГУРИРУЕМАЯ СИСТЕМА ДЛЯ ОЦЕНКИ ЧУВСТВИТЕЛЬНОСТИ СУБЪЕКТА К СТИМУЛУ И СПОСОБ ЕЕ ПРИМЕНЕНИЯ

Device for objective sensitivity testing

SYSTEM AND METHOD FOR PAIN DETECTION AND COMPUTATION OF A PAIN QUANTIFICATION INDEX

A method of detecting pain in subject comprises of generating brain wave data based on brain wave activity of subject and comparing the brain wave da ta to reference data to generate result data. The reference data corresponds to (i) population normative data indicative of brain wave activity of first plurality of individuals in an absence of pain, (ii) population reference d ata indicative of brain wave activity of second plurality of individuals gen erated in response to pain events inflicted on second plurality of individua ls, (iii) subjective population reference data indicative of brain wave acti vity of third plurality of individuals reporting a sensation of pain, and/or (iv) population of reference data indicative of brain wave activity of four th population of individuals following an intervention which has changed a s ubjective report of pain in combination with determining a presence of pain experienced by subject as a function of the result data.

RF hyperthermia device for personalized treatment and diagnosis

Device for monitoring exteroceptive sensitivities in particular for medical and in particular neurological applications

DEVICE AND METHOD FOR ASSESSING THERMOALGESIC AND VIBRATORY SENSITIVITY

DEVICE AND METHOD FOR EVALUATION OF VIBRATORY SENSITIVITY termo-algésicaTERMO-ALGÉSICA AND

Apparatus for providing an indication of a sensation

METHOD AND SYSTEM FOR DETECTING NEUROPATHY

The invention provides a system and method for detecting or monitoring neuropathy in an individual. The system of the invention includes a platform having a surface in which a plurality of stimulator's is embedded. Each stimulator is configured to stimulate a region in a skin area when the skin area is applied to the platform. The stimulator's may deliver thermal and/or vibrational energy to the skin region. In the method of the invention, a skin area is applied to platform and one of the stimulator's is activated. A minimal stimulation is determined that is sensed by the individual in a skin region in contact with a stimulator. Neuropathy in the skin region in contact with the stimulator is detected if either the determined minimal stimulation is above a predetermined threshold, or if a stimulation is not sensed before a magnitude of the stimulation reaches a predetermined maximal magnitude. The process is then repeated with other stimulator's.

COMPREHENSIVE PAIN ASSESSMENT SYSTEMS AND METHODS

Method and system for monitoring pain include a patient communication device such as a touch screen and microprocessor for executing a pain questionaire software application, an effector device, and a data processor (114).

OBJECTIVE PAIN MEASUREMENT SYSTEM AND METHOD

Methods, apparatuses and systems relating to the objective measurement of the subjective perception of pain in a subject are disclosed. In one aspect, a system for objectively measuring a subjective perception of pain by a subject comprises a plurality of electrodes, including a left channel electrode and a right channel electrode. The plurality of electrodes measures electrical activity at a respective plurality of sites on the subject to generate at least two sets of electrical activity measurements. The system further comprises a processor for processing the at least two sets of electrical activity measurements into at least two normalized signals, and comparing the at least two normalized signals to each other to identify the presence of pain in the subject.

ANALYSIS OF SKIN COLORATION

This document relates to computer-based systems and techniques for analyzing skin coloration using spectral imaging techniques to determine a medical condition of an individual. This document further relates to providing feedback to a rescuer or other medical professional based on the colorimetric properties of the patient's skin.

УСТРОЙСТВО И СПОСОБ ОЦЕНКИ ТЕРМАЛГЕЗИЙНОЙ И ВИБРАЦИОННОЙ ЧУВСТВИТЕЛЬНОСТИ

Группа изобретений относится к медицине. Устройство для оценки термалгезийной и вибрационной чувствительности содержит первый блок для приложения стимулирующих воздействий к локализованным точкам на теле пациента, представляющих собой вибрационные и температурные изменения, и второй блок для сбора данных. Первый блок содержит внешний корпус, средства вибрационного воздействия и средства для создания холода/тепла для непосредственного воздействия на пациента, а также средства включения/отключения и управления для приведения в действие первого блока и изменения интенсивности вибрации и температуры. Средства вибрационного воздействия и средства для создания холода/тепла находятся внутри внешнего корпуса и перемещаются линейно относительно корпуса для развертывания из него во время приложения стимулирующего воздействия. Второй блок содержит средства ввода данных, средства отображения данных, средства индикации различных режимов работы первого блока, а также средства количественной оценки данных ...

РЧ-УСТРОЙСТВО ДЛЯ ГИПЕРТЕРМИИ ДЛЯ ПЕРСОНАЛИЗИРОВАНОГО ЛЕЧЕНИЯ И ДИАГНОСТИКИ

... 1. Радиочастотное устройство для гипертермии для персонализированного лечения, персонализированной профилактики и персонализированной диагностики, использующее емкостную связь, содержащее радиочастотный источник (1), усилитель (2), датчик (3), модулятор (9) и вход/генератор (13) модулирующего сигнала, причем радиочастотный источник формирует сигнал (8) источника, который модулируется посредством модулятора (9), использующего модулирующий сигнал (12) для формирования модулированного сигнала (10) источника, причем модулированный сигнал (10) источника усиливается посредством усилителя (2) для формирования усиленного модулированного сигнала (4), который направляется в целевую область (17), и датчик (3) детектирует фазовую информацию, формируемую гомеостазом целевой области (17), и сравнивает фазовую информацию с ранее полученной фазовой информацией для создания сигнала (5) обратной связи, причем модулирующий сигнал (12) формируется посредством входа/генератора (13) модулирующего сигнала из ...

УСТРОЙСТВА, НАБОРЫ И СПОСОБЫ ДЛЯ ОПРЕДЕЛЕНИЯ НЕЭФФЕКТИВНОСТИ АНЕСТЕТИКОВ

Neuropathy test device

DEVICE AND PROCEDURE FOR AUTOMATIC EXAMINING OF THE TEMPERATURE SENSITIVITY OF A PATIENT

DEVICE AND PROCEDURE FOR THE MEASUREMENT OF SENSITIVE DISTURBANCES WITH CONSIDERATION OF DIFFERENT ENVIRONMENTAL CONDITION

Apparatus for providing an indication of a sensation in a reliability ensuring measurement series

Sonar-controlled apparatus for the delivery of electromagnetic radiation

Comprehensive pain assessment systems and methods

SONAR-CONTROLLED APPARATUS FOR THE DELIVERY OF ELECTROMAGNETIC RADIATION

The present invention comprises devices and methods that deliver electromagnetic radiation (EMR) from an emitter to a target and employ laser or sonar (a sensing method) to measure distance between target and the EMR emitter and automatically signal the emitter control circuitry to vary either the position or the power output of the emitter (as appropriate) in order to ensure that the effect of any change in distance on the energy incident to the target is compensated rapidly and automatically. In a preferred embodiment, the device is a hand-held, non-contact heatbeam dolorimeter.

CONFIGURABLE SYSTEM FOR EVALUATING STIMULUS SENSITIVITY OF A SUBJECT AND METHOD OF USE THEREFOR

A configurable system is used to evaluate stimulus sensitivity of a subject. An action channel provides a stimulus to the subject and a reaction channel receives a response from the subject. A signal pathway is connected to the action channel and to the reaction channel. A controller establishes loops within the signal pathway. Loop types include a transduction loop including the action channel and forming a path terminating in the signal pathway, and a channel loop including the action channel and terminating at a reference unit. Other possible loop types include an interface loop including the action channel, the reaction channel and the reference unit having an initial parameter value, and an adaptive loop including the action channel, the reaction channel and the reference unit whose parameter value is adapted based on the response from the subject. A method using the system is also described.

RF HYPERTHERMIA DEVICE FOR PERSONALIZED TREATMENT AND DIAGNOSIS

The present invention relates to a radiofrequency (RF) hyperthermia device for personalized treatment and diagnosis using capacitive coupling and without dipole antenna comprising a radiofrequency source, an amplifier, a sensor and a modulation signal input/generator, wherein the radiofrequency source produces a source signal which is modulated by the modulation signal input/generator using the phase information generated by homeostasis of the target to generate a modulated source signal, the modulated source signal is amplified by the amplifier and directed to a target, and the sensor detects the phase information generated by homeostasis of the target to provide a feedback signal, wherein the feedback signal modulates the source signal to generate a personalized modulated signal. This radiofrequency (RF) hyperthermia device is designed for personalized treatment and diagnosis of a target such as a patient or a malignant or tumorous area within a patient.

APPAREIL A TESTER LES SENSIBILITES SUPERFICIELLES

L'INVENTION CONCERNE UN DISPOSITIF RASSEMBLANT EN UN MEME OBJET UNE SOURCE CHAUDE, UNE SOURCE FROIDE, UNE AIGUILLE, UN PINCEAU ET UNE AMPOULE LUMINEUSE. CET APPAREIL EST DESTINE A TESTER LES SENSIBILITES SUPERFICIELLES, TACTILES, DOULOUREUSES, AINSI QUE LE REFLEXE DE DILATATION DE LA PUPILLE. IL EST CONSTITUE D'UN BOITIER COMPRENANT UN CIRCUIT PRODUCTEUR DE CHALEUR, UN CIRCUIT COMPRENANT UNE RESISTANCE ELECTRIQUE, UN CIRCUIT COMPRENANT UNE AMPOULE LUMINEUSE ET UN MECANISME PRODUCTEUR DE FROID QUI PEUT ETRE UN CORPS REFRIGERANT. CHAQUE SOURCE THERMIQUE ETANT MISE EN CONTACT AVEC LA PEAU SOIT DIRECTEMENT, SOIT PAR L'INTERMEDIAIRE D'UNE SURFACE DE CONTACT QUI POSSEDE UN VOYANT DE CONTROLE THERMIQUE. L'OBJET EST EQUIPE D'UN SYSTEME DE FIXATION.

DEVICE AND METHOD FOR ASSESSING THERMOALGESIC AND VIBRATORY SENSITIVITY

The invention relates to a device for assessing thermoalgesic and vibratory sensitivity, including a first unit (1) configured to apply, to localised points of the patient, a plurality of stimuli comprising vibrations and temperature changes, a second unit (2) for gathering data communicating with the first unit, wherein the communication between the first unit (1) and the second unit (2) takes place by means of a two-way wireless transmission means. The invention also relates to a method for assessing vibratory, thermal and thermoalgesic sensitivity using the device according to the invention.

DEVICE AND METHOD FOR ASSESSING THERMOALGESIC AND VIBRATORY SENSITIVITY

The invention relates to a device for assessing thermoalgesic and vibratory sensitivity, including a first unit (1) configured to apply, to localised points of the patient, a plurality of stimuli comprising vibrations and temperature changes, a second unit (2) for gathering data communicating with the first unit, wherein the communication between the first unit (1) and the second unit (2) takes place by means of a two-way wireless transmission means. The invention also relates to a method for assessing vibratory, thermal and thermoalgesic sensitivity using the device according to the invention.

APPARATUS FOR PROVIDING AN INDICATION OF SELECTED COMPONENTS OF A SENSATION

L'invention concerne un dispositif servant à mesurer le degré d'une sensation, d'une perception ou d'une capacité intégrée d'une personne. Le dispositif comporte un moyen de stimulation permettant de produire un stimulus physique sur la personne ; et un moyen servant à enregistrer une valeur de degré de sensation en réponse à un signal, provenant de la personne, qui indique que le stimulus provoqué correspond à la sensation à mesurer. Le dispositif conçu pour fournir un stimulus pulsatoire comporte un moyen permettant de faire varier les propriétés pulsatoires du stimulus à l'aide d'une modulation de durée d'impulsion, afin de mesurer la composante affective des sensations. D'autres formes de réalisation du dispositif comprennent également un moyen de variation d'amplitude pour mesurer la composante sensorielle des sensations.

AUTOMATIC TREATMENT OF PAIN

Disclosed are methods and medical device systems for automated delivery of therapies for pain and determination of need for and safety of treatment. In one embodiment, such a medical device system may comprise a sensor configured to sense at least one body signal from a patient; and a medical device configured to receive a first sensed body signal from the sensor; determine a patient pain index based at least in part on said first sensed body signal; determine whether said patient pain index is above at least a first pain index threshold; determine a safety index based at least in part on a second sensed body signal; select a pain treatment regimen based on at least one of said safety index and or a determination that said pain index is above said first pain index threshold; and deliver said pain treatment regimen.

STIMULUS PROVIDING DEVICE, PERCEPTION TRAINING METHOD, AND COMPUTER PROGRAM

The inventive concept relates to a stimulus providing device that provides training stimuli for improving pain of a pain patient, a perception training method, and a computer program. The stimulus providing device for providing a training stimulus for improving pain includes one or more mounting units mounted on body portions of a user, and one or more stimulus providing units disposed in the mounting units and which provides stimuli to the body portions, the stimulus providing units are controlled by a control unit included in the stimulus providing device or a control unit physically separated from the stimulus providing device to interwork with the stimulus providing device and included in a terminal of the user, and the control unit controls at least one of a location, a range, and an intensity of the stimuli.

Heat algometer

Portable apparatus for evaluating pain by processing measurements of the sensitivity and thermal pain thresholds, comprising: means (1) for cooling and heating a portion of the patient's skin; temperature detection means (1, 101) associated with said heating and cooling means (1); a central processing unit (2) which is connected to said heating and cooling means (1) and to said temperature detection means (1, 101) and is provided with a memory unit (202) and means for displaying the data detected (102); and power supply means ...

РЧ-УСТРОЙСТВО ДЛЯ ГИПЕРТЕРМИИ ДЛЯ ПЕРСОНАЛИЗИРОВАННОГО ЛЕЧЕНИЯ И ДИАГНОСТИКИ

Группа изобретений относится к медицинской технике, а именно к радиочастотным средствам для гипертермии. Устройство содержит радиочастотный источник, усилитель, датчик, модулятор и вход/генератор модулирующего сигнала, при этом радиочастотный источник формирует сигнал источника, который посредством модулятора, использующего модулирующий сигнал, формируется в модулированный сигнал источника. Модулированный сигнал источника усиливается и направляется в целевую область. Датчик выполнен с возможностью детектирования фазовой информации, формируемой гомеостазом целевой области в момент времени Tn+1, и сравнения ее с фазовой информацией, детектированной ранее в момент времени Tn, где n>0, для создания сигнала обратной связи. При этом модулирующий сигнал формируется посредством входа/генератора модулирующего сигнала из сигнала обратной связи посредством модулирования сигнала обратной связи, и вход/генератор модулирующего сигнала выполнен с возможностью использования фазовой информации измеренного ...

GERAET ZUR BESTIMMUNG DER TEMPERATUREMPFINDLICHKEIT DES PERIPHEREN NERVENSYSTEMS BEIM MENSCHEN.

Device for sensitivity testing

Device and method for assessing thermoalgesic and vibratory sensitivity

The invention relates to a device for assessing thermoalgesic and vibratory sensitivity, including a first unit (1) configured to apply, to localised points of the patient, a plurality of stimuli comprising vibrations and temperature changes, a second unit (2) for gathering data communicating with the first unit, wherein the communication between the first unit (1) and the second unit (2) takes place by means of a two-way wireless transmission means. The invention also relates to a method for assessing vibratory, thermal and thermoalgesic sensitivity using the device according to the invention.

COMPREHENSIVE PAIN ASSESSMENT SYSTEMS AND METHODS

Method and system for monitoring pain include a patient communication device such as a touch screen and microprocessor for executing a pain questionaire software application, an effector device, and a data processor (114).

ORIFICE PROBE AND METHOD OF USE THEREOF

An orifice probe, particularly for detecting if a patient has or has a risk of having cauda equina syndrome and a method for using same, the probe having a body for insertion into the anus of a patient, a sensing device for measuring at least one of the rectal tone and perianal or rectal sensation, and an output device for yielding at least one of the measurement of the rectal tone of the patient and whether the patient has perianal or rectal sensation.

Apparatus of examination of the cutaneous thermal sensitivity

Non-invasive, quantitative somatosensory method for the evaluation of erectile dysfunction

A non-invasive quantitative somatosensory method is provided for evaluating erectile dysfunctions and involves the applications to the glans penis of different temperatures in increments of about 1° C. until the patient can correctly identify which temperature starting at an ambient temperature was warmer for at least two consecutive times. The method of this invention provides a relatively simple procedure to assess a patient's neurological response to therapies. Incremental decreases in temperature can also be used to assess a patients's neurological response. The method of this invention can also be supplemented, if desired, by determination of the spatial perception threshold and/or the application of pressure, i.e., the sensitivity to touch determination to provide a two-point determination.

Device for performing diagnostic tests on the sensitivity to thermal stimuli

Device for performing diagnostic tests on the sensitivity of patients to thermal stimuli, comprising four elements (2, 3, 4, 5), arranged in a box (1) provided with a handle (6), each element having an external cylindrical metal surface to be contacted with the patient's epidermis, three of said elements being kept at three different standard temperature values, and the fourth at a selected temperature between 25 and 35°C.

КОНФИГУРИРУЕМАЯ СИСТЕМА ДЛЯ ОЦЕНКИ ЧУВСТВИТЕЛЬНОСТИ СУБЪЕКТА К СТИМУЛУ И СПОСОБ ЕЕ ПРИМЕНЕНИЯ

Изобретение относится к медицине, а именно к системе и способу оценки чувствительности субъекта к стимулу, а также к системе для улучшения чувствительности первого сенсорного, рефлекторного и моторного механизма субъекта. Система для оценки чувствительности субъекта к стимулу содержит первый канал действия, канал реакции, сигнальный путь, контроллер. Первый канал действия выполнен с возможностью создания стимула первого типа для субъекта. Канал реакции выполнен с возможностью приема ответа от субъекта. Каналы действия и реакции реализованы посредством приводов и датчиков. Сигнальный путь соединен с первым каналом действия и с каналом реакции. Контроллер выполнен с возможностью установления первого контура преобразования, первого контура канала, контура интерфейса, адаптивного контура. Первый контур преобразования включает в себя первый канал действия и образует путь, оканчивающийся в сигнальном пути. Первый контур канала включает в себя первый канал действия, образует путь через сигнальный ...

УСТРОЙСТВО И СПОСОБ ОЦЕНКИ ТЕРМАЛГЕЗИЙНОЙ И ВИБРАЦИОННОЙ ЧУВСТВИТЕЛЬНОСТИ

... 1. Устройство для оценки термалгезийной и вибрационной чувствительности, содержащее:первый блок (1), выполненный с возможностью приложения к локализованным точкам на теле пациента множества стимулирующих воздействий, представляющих собой вибрационные и температурные изменения,второй блок (2), предназначенный для сбора данных, обмен которыми осуществляется с первым блоком, отличающееся тем, что первый блок (1) содержит:внешний корпус (3),средства (4) вибрационного воздействия и средства (4') для создания холода/тепла, выполненные с возможностью непосредственного воздействия на пациента, которые находятся внутри внешнего корпуса (3), перемещаются линейно относительно корпуса для развертывания из него во время приложения стимулирующего воздействия, а такжесредства (5) включения/отключения и управления, выполненные с возможностью приведения в действие первого устройства (1) и изменения интенсивности как вибрации, так и температуры,тем, что второй блок (2) содержит:средства (6) ввода данных, ...

Temperatursinn-Prüfgerät für die neurologische Routinediagnostik

Temperatursinn-Prüfgerät zum Einsatz auf der Hautoberfläche, dadurch gekennzeichnet, dass die aktive Erwärmung und Abkühlung der Kontaktflächen durch die Verwendung von Peltier-Elementen erfolgt und das Gerät batteriebetrieben ist.

Device for sensitivity testing

Heat beam dolorimeter

DEVICE AND METHOD FOR THE MEASUREMENT OF SENSORY DISORDERS WITH REGARD TO VARIOUS ENVIRONMENTAL CONDITIONS

DEVICES, KITS, AND METHODS FOR DETERMINING INEFFECTIVENESS OF ANESTHETICS

In general, the invention provides kits, devices, and methods for determining the ineffectiveness of an anesthetic, (e.g., lidocaine), using a topical approach that avoids injection. The methods typically employ the placement of aliquots of two different formulations, at least one including an anesthetic, in different locations on a subject. Further embodiments may employ a single formulation including the anesthetic.

Apparatus for testing surface sensitivities

DEVICE FOR PROVIDING STIMULATION, METHOD FOR TRAINING PERCEPTION AND COMPUTER PROGRAM

AUTOMATIC TREATMENT OF PAIN

Disclosed are methods and medical device systems for automated delivery of therapies for pain and determination of need for and safety of treatment. In one embodiment, such a medical device system may comprise a sensor configured to sense at least one body signal from a patient; and a medical device configured to receive a first sensed body signal from the sensor; determine a patient pain index based at least in part on said first sensed body signal; determine whether said patient pain index is above at least a first pain index threshold; determine a safety index based at least in part on a second sensed body signal; select a pain treatment regimen based on at least one of said safety index and or a determination that said pain index is above said first pain index threshold; and deliver said pain treatment regimen.

Kältereflextestvorrichtung

Die vorliegende Erfindung betrifft eine Kältereflextestvorrichtung, bei der eine elektrische Vorrichtung, welche zum Steuern der Temperatur und Aufrechterhalten einer festen Temperatur auf einem niedrigen Niveau basierend auf einem elektrischen Signal aus einem Steuergerät eingerichtet ist, in einem Kältestimulator verwendet wird, der als ein Mittel zum Anlegen eines Kältereizes an einen Körper einer Person in Berührung mit dem Körper der Person gebracht wird. Somit ist es möglich, während der Messung einen konstanteren Reiz auf den Körper der Person auszuüben und folglich die Zuverlässigkeit der Messung zu verbessern. Die Kältereflextestvorrichtung der vorliegenden Erfindung kann einen Kältestimulator zum Aufbringen eines Kältereizes an einen in Berührung mit dem Kältestimulator stehenden Körper einer Person durch Aufrechterhalten einer festen niedrigen Temperatur basierend auf einem durch ein Steuergerät vorgegebenen elektrischen Signal, einen Blutdurchflussmesser zum Messen der Blutströmungsgeschwindigkeit ...

HOT & COLD SENSOR DISCRIMINATION UNIT

APPARATUS AND METHODS FOR TESTING PAIN SENSITIVITY

Objective pain measurement system and method

Multi-modal pharmaco-diagnostic assessment of brain health

A single diagnostic dose of a chemical agent that can bind with molecular specificity or provide a well characterized molecular effect on a mammalian host (including humans) is provided to a patient between brain scans. The method typically comprises at least one pre- dose scan of the subject followed by a waiting period then a second post-dose diagnostic scan. The diagnostic scans can be conventional in nature or of a multi-modal variety. A comparison, in the form of a difference or ratio, between data or extracted features before versus after the diagnostic dose indicates with molecular specificity the tone in the brain of that subject. The resulting data may be used to assess instances of medical fraud and can be used in back to work decisions for brain and soft tissue injuries for which the determinations have traditionally been somewhat subjective in nature.

Device for measurements of thermal perception in body cavities

A NON-INVASIVE, QUANTITATIVE SOMATOSENSORY METHOD FOR THE EVALUATION OF ERECTILE DYSFUNCTION

A non-invasive quantitative somatosensory method is provided for evaluating erectile dysfunctions and involves the applications to the glans penis of different temperatures in increments of about 1° C until the patient can correctly identify which temperature starting at an ambient temperature was warmer for at least two consecutive times. The method of this invention provides a relatively simple procedure to assess a patient’s neurological response to therapies. Incremental decreases in temperature can also be used to assess a patient’s neurological response . The method of this invention can also be supplemented, if desired, by determination of the spatial perception threshold and/or the application of pressure, i.e., the sensitivity to touch determination to provide a two-point determination.

センセーションの選択された成分の表示を提供する装置

... 人間のセンセーション、知覚、または、統合スキルのレベルを測定する装置であって、この装置は、肉体的刺激を人間に対して誘発する刺激手段と、誘発された刺激が測定すべきセンセーションに相当するという人間からの表示信号に応答してセンセーション・レベル値を登録する手段とを備えている。この装置は、センセーションの感情成分を測定するために、パルス幅変調によって刺激の脈動特性を変化させる手段を有する脈動刺激を提供するようになっている。さらに、この装置を発展させたものはセンセーションの感覚成分を測定するために振幅変化手段も備えている。 ...

DEVICE FOR SENSITIVITY TESTING

PROBLEM TO BE SOLVED: To provide devices and methods for sensitivity test. SOLUTION: The disclosed devices include a flexible catheter body having a distal end and a proximal end, a peltier element, a contact element located at or near the distal end of the catheter body that can be heated or cooled by applying a voltage to the peltier element, and a contact sensor for detecting contact between a contact surface of the contact element and tissue to be tested. COPYRIGHT: (C)2012,JPO&INPIT ...

Hot and cold sensing discrimination unit

A hot and cold sensor discrimination unit having an insulated liquid-filled container with a temperature indicator and a metal probe with a temperature indicator for use in perception of temperature by a patient.

Devices, kits, and methods for determining ineffectiveness of anesthetics

In general, the invention provides kits, devices, and methods for determining the ineffectiveness of an anesthetic, (e.g., lidocaine), using a topical approach that avoids injection. The methods typically employ the placement of aliquots of two different formulations, at least one including an anesthetic, in different locations on a subject. Further embodiments may employ a single formulation including the anesthetic.

Device for thermal stimulation of small neural fibers

Orifice probe and method of use thereof

An orifice probe, particularly for detecting if a patient has or has a risk of having cauda equina syndrome and a method for using same, the probe having a body for insertion into the anus of a patient, a sensing device for measuring at least one of the rectal tone and perianal or rectal sensation, and an output device for yielding at least one of the measurement of the rectal tone of the patient and whether the patient has perianal or rectal sensation.

THERMAL STIMULATION DEVICE COLD OR HOT AND ITS CONTROL METHOD, AND CONTROL

La présente invention concerne un procédé de contrôle et de commande pour un dispositif de stimulation thermique d'un tissu (1) animal ou humain, caractérisé en ce qu'il consiste à déterminer une température neutre appliquée au tissu (1), à effectuer une régulation thermique sur la température neutre en activant une boucle de régulation, à déterminer une température de stimulation thermique froide ou chaude à appliquer au tissu (1) en alternance avec la température neutre, à déterminer une durée et une fréquence des stimulations thermiques, en cas d'instruction de déclenchement de la stimulation, à effectuer une régulation sur la température de stimulation thermique en activant une boucle de régulation et en désactivant la boucle de régulation sur la température neutre, à synchroniser un enregistrement physiologique avec la stimulation thermique.

Thermal sensitivity testing device, for investigation of a patient's response to hot and cold stimuli, comprises a Peltier element that is used to provide hot and cold surfaces that can be applied to a patient's skin

L'invention concerne un dispositif générant une différence de température et permettant donc de tester la sensibilité thermique d'un patient en appliquant successivement la face chaude et la face froide du dispositif sur la peau. Il est constitué d'un boîtier (1) fermé à une extrémité par un capuchon (2) et à l'autre extrémité par un élément articulé (11) reliant le boîtier (1) à un module Peltier (9). L'alimentation électrique se trouve dans le boîtier (1) et à la surface du boîtier(1) apparaissent un interrupteur électrique(7) ainsi qu'un témoin lumineux de mise en tension (8). Le dispositif selon l'invention est particulièrement destiné à l'examen médical neurologique des patients.

DEVICE FOR ALLEVIATING PAIN OF TEMPOROMANDIBULAR JOINT

A device for alleviating pain of a temporomandibular joint according to the present invention includes: a headset frame with both ends positioned at the painful region of the temporomandibular joint; a high frequency electrode part provided at both ends of the headset frame for generating a high frequency signal for healing the painful region of the temporomandibular joint; a temperature sensor part provided at both ends of the headset frame for detecting the temperature of the painful region of the temporomandibular joint of a patient and the surrounding region thereof; a high frequency generation part for generating the healing high frequency signal outputted from the electrode part; and a control unit for controlling the high frequency generation part according to the temperature detected by the temperature sensor so as to adjust the intensity of the output high frequency signal. Thus the headset type frame makes the high frequency electrode and a low output laser correctly positioned ...

Hot and cold sensor discrimination unit

A hot and cold sensor discrimination unit having an insulated liquid-filled container with a temperature indicator and a metal probe with a temperature indicator for use in perception of temperature by a patient.

Central sensitization diagnosis device and method for operating same

An object of the present invention is to provide a system for performing objective examination of central sensitization, in particular, a system for objectively determining the presence or absence of central sensitization in a chronic pain patient. The present invention provides a device for diagnosing the presence or absence of central sensitization, the device including: stimulation output means for outputting thermal stimulation which can be perceived by a subject; first input means capable of inputting a measurement start signal; second input means capable of inputting a measurement end signal; and measurement control means for measuring time between an input signal from the first input means and an input signal from the second input means. The measurement control means determines that the central sensitization is present when the time between the input signal from the first input means and the input signal from the second input means is longer than t seconds (where t represents 30 ...

Test device for diabetes polyneuropathy diagnosis has test rod with longitudinal slot for in and out pivoting of extended test bristle fixed to one end on transverse shaft

The device has an elongated test rod (1) with an outer surface (2) and longitudinal ends (3,4), one consisting of a cold test head (5) of a good thermal conductor material and the other as a hot test head (6) of a poor thermal conductor material. The rod has a longitudinal slot (12) for in and out pivoting of an extended test bristle (13) fixed to one end on a transverse shaft (15).

Configurable system for evaluating stimulus sensitivity of a subject and method of use therefor

A configurable system is used to evaluate stimulus sensitivity of a subject. An action channel provides a stimulus to the subject and a reaction channel receives a response from the subject. A signal pathway is connected to the action channel and to the reaction channel. A controller establishes loops within the signal pathway. Loop types include a transduction loop including the action channel and forming a path terminating in the signal pathway, and a channel loop including the action channel and terminating at a reference unit. Other possible loop types include an interface loop including the action channel, the reaction channel and the reference unit having an initial parameter value, and an adaptive loop including the action channel, the reaction channel and the reference unit whose parameter value is adapted based on the response from the subject. A method using the system is also described.

METHOD AND APPARATUS FOR TREATING CENTRALIZED PAIN

A method for alleviating centralized pain in human subjects includes assessing the brain of a subject suffering from pain, diagnosing abnormal brain function associated with centralized pain, locating at least one area of abnormal brain function associated with the centralized pain, and alleviating the abnormal brain function by applying a cortical stimulation signal to tissues corresponding to the at least one area of abnormal brain function.

METHOD AND APPARATUS FOR DIAGNOSING AND ASSESSING CENTRAL PAIN

Methods for central pain diagnosis and assessment, symptom severity prediction, and therapeutic intervention effect determination. The diagnosis and assessment method includes a statistical comparison between a subject's quantitative brain function assessment and either a database of quantitative assessments of brain functions of healthy individuals, or a database of quantitative assessments of brain functions of individuals known to have been suffering from chronic pain as a result of the abnormal brain function condition. Diagnosis and assessment may be accomplished using a neuroimaging device to sense and generate images representing central nervous system function, using a sensory stimulation device to stimulate brain activities associated with central sensitivity, and using a computing device to command the sensory stimulation device and neuroimaging device to test for the presence of central pain.

DISPOSITIF DE CONTROLE DES SENSIBILITES EXTEROCEPTIVES NOTAMMENT POUR DES APPLICATIONS MEDICALES ET PARTICULIEREMENT EN NEUROLOGIE

DISPOSITIF DE CONTROLE DES SENSIBILITES EXTEROCEPTIVES NOTAMMENT POUR DES APPLICATIONS MEDICALES ET PARTICULIEREMENT EN NEUROLOGIE. DISPOSITIF CARACTERISE EN CE QU'IL COMPREND UNE SONDE 1 APPLICABLE SUR LA PARTIE 12 DU CORPS A EXAMINER PAR L'INTERMEDIAIRE D'UNE SURFACE D'APPUI NEUTRE 11 AYANT AU MOINS UN ELEMENT D'EXCITATION 17, 18, 26, 34 D'UNE SENSIBILITE EXTEROCEPTIVE, SUSCEPTIBLE D'AGIR DE FACON COMMANDEE SUR LA PARTIE 12 DU CORPS A EXAMINER, ET UN CIRCUIT DE COMMANDE 2 MUNI DE MOYENS DE REGLAGE ET DE COMMANDE 6, 7 DES ELEMENTS D'EXCITATION 17, 18, 26, 34 POUR METTRE EN OEUVRE CES ELEMENTS D'EXCITATION AFIN D'EXERCER UNE STIMULATION PRECISE. L'INVENTION S'APPLIQUE A UN DISPOSITIF DE CONTROLE DES SENSIBILITES EXTEROCEPTIVES NOTAMMENT POUR DES APPLICATIONS MEDICALES ET PARTICULIEREMENT EN NEUROLOGIE.

THERMAL STIMULATION DEVICE AND ITS CONTROL METHOD, AND CONTROL

La présente invention concerne un procédé de contrôle et de commande pour un dispositif de stimulation thermique froide d'un tissu (1) animal ou humain, caractérisé en ce qu'il consiste à déterminer une température neutre appliquée au tissu (1), à effectuer une régulation thermique sur la température neutre en activant une boucle de régulation, à déterminer une température de stimulation thermique froide à appliquer au tissu (1) en alternance avec la température neutre, à déterminer une durée et une fréquence des stimulations thermiques froides, en cas d'instruction de déclenchement de la stimulation, à effectuer une régulation sur la température de stimulation thermique froide en activant une boucle de régulation et en désactivant la boucle de régulation sur la température neutre, à synchroniser un enregistrement physiologique avec la stimulation thermique froide et à réactiver la boucle de régulation sur la température neutre après chaque stimulation thermique froide.

dispositivos, kits, e métodos para determinar a ineficácia de anestésicos

APPARATUS FOR PROVIDING AN INDICATION OF A SENSATION IN A RELIABILITY ENSURING MEASUREMENT SERIES

L'invention concerne un appareil permettant de mesurer le degré d'une sensation, d'une perception ou des capacités innées d'une personne, l'appareil étant pourvu d'éléments de stimulation servant à induire un stimulus physique à la personne et des moyens destinés à enregistrer une valeur de degré de sensation en réaction à un signal d'indication de la personne dont le stimulus induit correspond à la sensation à mesurer. L'appareil est conçu pour produire un stimulus pulsatoire présentant des moyens permettant de faire varier le taux d'accroissement du stimulus physique de manière à assurer la fiabilité des mesures. Dans un autre mode de réalisation de la présente invention, l'appareil permet d'apporter de façon sélective un premier stimulus physique comparable à une composante affective d'une sensation ou un second stimulus physique comparable à une composante sensorielle d'une sensation.

NEUROMECHANICAL ALGOMETER

Systems and methods for the diagnosis of chronic pain are disclosed. An algometer comprising a pressure sensor and electrode is disclosed. The algometer may be used to measure pressure applied by a clinician at a location on a patient's body, along with EMG signals emanating from the same location of the patient. Further, a pain trigger operable by the patient may be used in coordination with the algometer. Data from the algometer and pain trigger are transmitted to a computing device and display for rendering and analysis of patient data, leading to improved diagnosis.

Systems, devices, and methods for monitoring an under foot load profile of a patient during a period of partial weight bearing

Systems, devices, and methods for measuring an under foot load profile of a patient during a period of partial weight bearing are described. The system may include a walking boot cast. A housing, including an inner surface and an upper surface that cooperate to define an inner cavity, may be oriented with respect to a patient's leg. The upper surface may be slidably received within the inner cavity in a piston and cylinder configuration or may be otherwise configured. The system may include a pressure sensor configured to monitor the load profile of a patient during the desired period of partial weight bearing. The pressure sensor may be located below the upper surface. The system may include a noncompressible force transmitter positioned within the inner cavity and at least partially encapsulating an upper portion of the pressure sensor to transmit pressure within the housing to the pressure sensor.

Apnea type determining apparatus and method

An apnea classification system provides for apnea monitoring and differentiation based on several sleep apnea related parameters for diagnostic and therapeutic purposes. Monitoring of such sleep apnea related parameters allows the apnea classification system to differentiate among the different types of apnea and hypopnea and to identify an occurrence of periodic respiration. This information may then be used to determine the best method of therapy, or adjust current therapy parameters to more effectively treat a subject.

Seizure detection using coordinate data

A seizure detection device includes a coordinate data interface configured to receive coordinate data for a human, a memory to store coordinate data for a defined location of the human, and a seizure detector configured to identify a seizure event responsive to the coordinate data.

Medical device and methods of monitoring a patient with renal dysfunction

Embodiments relate to a method of monitoring physiological parameters of a patient with renal dysfunction. The method includes electrically connecting one or more medical device electrodes with a measurement site of a patient, generating one or more first stimulation signals sufficient to provide input physiological parameters specific to the patient, measuring one or more first bioimpedance values from the generated signals, analyzing at least one of the input physiological parameters within the one or more first bioimpedance values and generating a personalized dialysis program. The systems and methods can further provide essentially real-time data of patient undergoing treatment and control of treatment to a patient.

Apparatus, System and Method for Ultrasound Powered Neurotelemetry

The present embodiments provide an apparatus, system, and method for ultrasound powered neurotelemetry. In one embodiment, the apparatus includes a piezoelectric element configured to receive an ultrasonic pulse and convert the electronic pulse into an electric potential. A diode may be coupled to the piezoelectric element, the diode configured to cause an electric current to flow in response to the electric potential. The apparatus may additionally include a reference electrode and a stimulating electrode coupled to the diode. The reference electrode may sense bioelectric activity in a region of body tissue located in proximity to the reference diode. The stimulating electrode may emit a carrier signal, wherein the carrier signal is modulated in response to the bioelectric activity sensed by the reference electrode.

Multiple section parenteral drug delivery apparatus

The invention relates to a parenteral therapeutic agent delivery device. The therapeutic agent delivery device has a disposable section and an implant section suitable for long term implantation within the tissue of a subject. When necessary, the disposable section can be detached from the implant section, and a new disposable section can be attached. The disposable section may contain a reservoir containing the therapeutic agent, a pump for dispensing the therapeutic agent, controlling circuitry for regulating the dispensing of the therapeutic agent, and transceiver circuitry and an antenna for wireless communication with external devices.

Medical device for glucose monitoring or regulation

A medical device comprising a pressure generating means adapted to displace a liquid, a sensor adapted to measure a flow resistance, and an implantable member comprising an analyte responsive porous membrane which reversibly changes its porosity subject to changes in analyte concentration occurring in the solution surrounding the implantable member. The analyte may in particular be glucose. The medical device may also be used for drug administration.

Method and device for monitoring and improving arteriogenesis

A method for determining an arteriovascular condition of a subject having an arterial blood flow is shown. The method involves determining a temporal progression of an instantaneous blood flow condition of the arterial blood flow as well as deriving a slew rate of the temporal progression during an increase of the temporal progression. In addition, an arteriovascular condition indicator device is shown, which comprises: an input for receiving an input signal representing an instantaneous arterial blood flow condition of a subject and a slew rate monitor connected to the input. A corresponding control device for providing an activation signal is also shown. The control device comprises a maximum detector connected to the slew rate monitor. A method for stimulation of arteriogenesis is also shown, wherein a temporal progression of an instantaneous blood flow condition is monitored, a slew rate of the temporal progression is derived, and the maximum of the slew rate is determined. An external pressure is applied repeatedly to the arteriovascular section in synchronization with the occurrence of the determined maximum.

Communication System Incorporated in an Ingestible Product

The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also be associated with food and communicate data about ingestion of food material to a receiver.

System and method for physiological monitoring

Apparatus, systems, and methods for monitoring a sensor module mounted in a sensor platform, wherein the sensor platform includes an adhesive side and a pocket, wherein the pocket is designed to receive the sensor module, to facilitate sensing by the sensor module of physiological attributes, and to allow insertion and removal of the sensor device from the pocket.

Blood Flow Monitoring

The present invention relates to a method of utilizing photoplethysmography obtained from a central site and a non-central site to detect a low blood flow or low blood volume condition. Also disclosed are apparatuses and systems designed to acquire and process physiological information based on photoplethysmograpy signal information from dual sites.

Method and Apparatus of Neural Signal Determination and Therapy Enhancement

A method and device are provided that detect and identify a neural signal by type and optionally or automatically provide a signal that affects a nerve carrying the neural signal. A plurality of electrodes is positioned along a nerve and monitors the electrical activity of the nerve. The invented system analyzes the monitored data to determine when the monitored activity can be identified as a known type of bioelectric signal, e.g., a pain nerve signal. The system may optionally attempt to affect, disrupt, diminish, nullify or block transmission of bioelectric signals along the nerve, e.g., by directing electrical energy through an electrode to nullify a bioelectric signal along a pain nerve.

Management Method And System For Implementation, Execution, Data Collection, and Data Analysis Of A Structured Collection Procedure Which Runs On A Collection Device

A collection device for performing a structured collection procedure may include a processor that executes program instructions communicably coupled to at least one memory. The processor can initiate a schedule of events of the structured collection procedure upon one or more entry criterions being met and segregate the at least one memory into a primary data store and a secondary data store. The processor can write structured patient data collected in accordance to the schedule of events to the secondary data store. The processor can transform a relevant portion of the structured patient data into an evaluated data object. The processor can generate a data abstraction based in part upon the evaluated data object. The processor can link the primary data store and the secondary data store with the data abstraction.

Agents and methods for denervation

Various agents are described to denerve, modulate, or otherwise affect the renal nerves and other neural tissue. Also, various delivery devices are described to deliver an agent locally to the renal nerves. The delivery devices are positioned in the renal artery and penetrate into the wall of the renal artery to deliver the agent to the renal nerves. The delivery devices may be used to deliver the agent according to longitudinal position, radial position, and depth of the renal nerves relative to the renal artery. In addition, various methods are described to denervate, modulate, or otherwise affect the renal nerves and other neural tissue.

Automated adaptive muscle stimulation method and apparatus

An automated adaptive muscle stimulation system and method are disclosed. The stimulation system includes at least one electrode assembly adapted to deliver a muscle stimulation signal to the tissue of a user, a sensor system adapted to detect a muscle response, and an electrical stimulation device operably coupled to the at least on electrode assembly and the sensor system, the electrical stimulation device including a control system operable to automatically diagnose at least one characteristic of a muscle from the detected muscle response and adjust at least one parameter of the muscle stimulation signal in response thereto to deliver an adjusted muscle stimulation signal. A dual mode muscle stimulation system adapted to accept first and second data sets and provide first and second levels of treatment data is also disclosed.

Real-Time Evaluation of CPR Performance

A computer-implemented method for providing summary information for lifesaving activities is disclosed. The method involves sensing one or more activities that are repeatedly and cyclically performed on a victim by a rescuer; identifying a cyclical timing interval over which performance is to be analyzed for a integer number of cycles of the one or more activities, and gathering data from the sensing of the one or more activities during the time interval; generating, from analysis of the one or more activities, summary data that condenses data sensed for the one or more activities into a summary of the one or more activities; and providing, for display to a user, a visual summary of the performance of the one or more activities over the identified time interval.

Determination and application of glucose sensor reliability indicator and/or metric

Disclosed are a system and method for determining a metric and/or indicator of a reliability of a blood glucose sensor in providing glucose measurements. In one aspect, the metric and/or indicator may be computed based, at least in part, on an observed trend associated with signals generated by the blood glucose sensor.

Orifice probe apparatus and a method of use thereof

An orifice probe, particularly for detecting if a patient has or has a risk of having cauda equina syndrome and a method for using same, the probe having a body for insertion into the anus of a patient, a sensing device for measuring at least one of the rectal tone and perianal or rectal sensation, and an output device for yielding at least one of the measurement of the rectal tone of the patient and whether the patient has perianal or rectal sensation.

Focal medication titration system

A system is provided for implantation into the skull of a patient including a device to detect the onset and/or existence of a neurological condition and deliver a medication to prevent the neurological condition, and/or to improve or sustain normal neurological function. Methods for utilizing the system and device are also provided.

Device, system and method for meal detection for interfacing with and controlling auxiliary devices associated therewith

The present invention relates to a device, system and method for detecting meal event in a subject and in particular to such a device, system and method for communicating and controlling auxiliary devices and/or systems associated therewith.

Method for assessing the susceptibility of a human individual suffering from a psychiatric or neurological disorder to neuromodulation treatment

Method for assessing the susceptibility of a human individual suffering from a psychiatric or neurological disorder, in particular with depressed mood as a predominant feature, to neuromodulation treatment, in particular repetitive Transcranial Magnetic Stimulation (rTMS), the method comprising: a) Providing a dataset comprising electroencephalographic (EEG) activity and Event Related Potentials (ERP) data of said human individual; b) Assessing the susceptibility of said human individual to neuromodulation treatment based on said dataset.

Reagents and methods for modulating cone photoreceptor activity

The present invention provides reagents and methods for modulating cone photoreceptor activity, and devices for assessment of cone photoreceptor activity.

Glycemic health metric determination and application

Disclosed are methods, apparatuses, etc. for determination and application of a unidimensional metric for assessing a patient's glycemic health. In one particular implementation, a computed metric may be used to balance short-term and long-term risks associated with a particular therapy. In another implementation, a computed unidimensional metric may be used to balance risks of hyperglycemia and hypoglycemia.

Imaging-guided joint injection system

Systems for injecting fluids and/or other materials into a targeted anatomical location, in particular, an intra-articular space, include a handpiece assembly having a proximal end and a distal end, a needle extending from the distal end of the handpiece assembly, a fluid delivery module comprising a cassette and a fluid transfer device. A conduit is generally configured to place the fluid delivery module in fluid communication with the handpiece assembly. Medications, formulations and/or other fluids or materials contained within vials that are secured to the fluid delivery module can be selectively delivered into an anatomy through a needle located at the distal end of the handpiece assembly. In some embodiments, ultrasound or other imaging technologies can be used to locate a joint or other targeted anatomical location.

Pain tracking and management device

A system, method and apparatus for real time measurement and monitoring of various personal health parameters including controlled delivery of drugs/medications by intelligent pump appliances, intelligent inhalation appliances and intelligent skin patch appliances used in a standalone manner or in a wired or wireless networked configuration, in conjunction with various peripheral devices, other intelligent appliances, servers, RF ID Tags and stationary/mobile devices. The intelligent appliances relate to the measurement, monitoring and delivery of insulin/other drugs for the treatment of diabetes and other diseases. The method also additionally includes the application of intelligent appliances for pain management including visualization of organs and body locations exhibiting pain.

Robotically-controlled surgical instrument with force-feedback capabilities

A surgical instrument. Various embodiments of the surgical instrument include an end effector that has a moveable cutting implement. A main drive shaft assembly operably interfaces with the end effector for transmitting an actuation motion to the movable cutting implement therein. A gear drive train is connected to the main drive shaft assembly. The gear drive train is actuated by a motor that is configured to receive control signals from a robotic system. Various embodiments include a sensor arrangement that operably interfaces the end effector to communicate forces experienced by the end effector to the robotic system.

Systems for remote generation of electrical signal in tissue based on time-reversal acoustics

A time-reversal acoustics system includes a transmitter configured to send a high intensity acoustic waveform signal focused on an implantable receiver. The receiver includes a piezoelectric transducer configured to convert received acoustic energy to an electrical signal used to energize an internal electrical circuit. Such circuit may be used to operate at least one tissue stimulating electrode, at least one sensor such as an ECG sensor, charge an internal battery or perform another useful function. The system of the invention may be used as a wireless cardiac pacemaker or a neurostimulator.

Medical device

A modular medical device includes a core module housing. The core module housing includes a treatment module interface configured to couple to any one of a plurality of treatment modules, and each of the plurality of treatment modules includes a treatment assembly configured to apply a medical treatment. The core housing module contains one or more processing devices coupled to the treatment module interface and configured to determine which particular treatment module, from the plurality of treatment modules, is coupled to the treatment module interface. The one or more processing devices are configured to select, based on the determination, a set of control instructions for the particular treatment module from a plurality of control instructions, and control the particular treatment module using the selected control instructions such that the treatment assembly of the particular treatment module applies the medical treatment for which the treatment assembly is configured.

Device, Methods, and Control for Sonic Guidance of Molecules and Other Material Utilizing Time-Reversal Acoustics

The present invention provides for a method of controlling mass movement of fluid material within a field of interest comprising using time reversal acoustic focusing. The time reversal acoustic focusing can be is used for simultaneous spatial and temporal focusing of acoustic energy to control the duration of localization and/or direction of movement of material within tissue or liquid within tissue. Both delivery of material and persistence with respect to target locations can be enhanced by focusing of sonic waveforms or transmissions towards targeted areas in a field of interest, such as within a patient.

Bodily fluid composition analyzer with disposable cassette

Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.

ECG Artifact Reduction System

An ECG signal processing system which removes the CPR-induced artifact from measured ECG signals obtained during the administration of CPR.

Nerve treatment system

In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.

Drug Delivery Method Via Brain Extracellular Space and a Device Thereof

The present invention relates to a method for drug delivery via brain extracellular space (ECS). It includes putting head of patient in an imaging apparatus; generating dynamic images of the brain via the imaging apparatus; delivering drugs into brain ECS of the patient according to the dynamic images and the drugs get to the therapeutic target by simple diffusion along concentration gradient. The present invention also relates to a device for drug delivery via brain ECS. Basing on the self-diffusion delivery (SDD) of drugs in brain ECS, the present invention can deliver drug into the ECS of the brain's relatively safe area in low speed, with small amounts of doses and without extra stress. Therefore, the present invention can reduce delivery time and dose of drugs, relieve injection pressure, decrease damages on normal brain tissue, and reduce the cost of treatment observably.

Apparatus and method for treating obstructive sleep apnea

The present invention describes an apparatus, a system and a method for the treatment of obstructive sleep apnea. The treatment involves monitoring the position of the tongue and/or the force exerted by the tongue and electrical stimulation of the hypoglossal nerve to move the tongue into an anterior position or to maintain the tongue in an anterior position.

Health monitoring appliance

A heart monitoring system for a person includes one or more wireless nodes; and a wearable appliance in communication with the one or more wireless nodes, the appliance monitoring vital signs. Other implementations can monitor heart rate, heart rate variability, respiratory rate, fluid status, posture and activity.

Controlled titration of neurostimulation therapy

Described herein are methods and devices that utilize electrical neural stimulation to treat heart failure by modulating a patient's autonomic balance in a manner that inhibits sympathetic activity and/or augments parasympathetic activity. Because other therapies for treating heart failure may also affect a patient's autonomic balance, a device for delivering neural stimulation is configured to appropriately titrate such therapy in either an open-loop or closed-loop fashion.

Non-invasive, vibrotactile medical device to restore normal gait for patients suffering from peripheral neuropathy

Provided is a comfortable and discrete device wearable by a patient to restore balance and gait. The device re-establishes the sensorimotor loop by providing the patient with a secondary signal to healthy nerves around the knee to alert the patient that the patient's heel has just struck the ground. In this regard, the device monitors the patient's leg movements to detect when the patient's heel strikes the ground and sends the secondary signal, i.e., vibrotactile stimulation, in response to the detected heel strike. The central nervous system incorporates the new signal and the motor system responds as if there is not loss of sensation in the foot and returns to its normal gait.

Goal-directed fluid therapy

A method includes setting a hydration goal and administering a diuretic to the patient to induce increased urine flow and collecting urine expelled by the patient. The amount of urine expelled by the patient is determined based on the collected urine. The patient is infused with fluid from a fluid source. The amount of fluid infused into the patient is determined. Diuresis is induced by automatically and continuously adjusting the amount of fluid infused into the patient from the fluid source to meet the hydration goal based on the set hydration goal, the determined amount of urine expelled by the patient and the fluid infused.

Dosage regimen of an s1p receptor modulator

S1P receptor modulators are administered following a dosage regimen providing a positive benefit-risk profile.

Advanced analyte sensor calibration and error detection

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Energetic modulation of nerves

A system to modulate an autonomic nerve in a patient utilizing transcutaneous ultrasound energy delivery includes a processor comprising an input for receiving information regarding energy and power to be delivered to a treatment region containing the nerve, and an output for outputting a signal, wherein the processor is configured to determine a position of a reference target from outside the patient to localize the nerve relative to the reference target, a therapeutic energy device comprising a transducer for delivering ultrasound energy from outside the patient, a controller to control an aiming of the transducer based at least in part on the signal from the processor, and an imaging system coupled to the processor or the therapeutic energy device.

Integrated delivery device for continuous glucose sensor

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

Medication management and reporting technology

Medication management and reporting technology, in which output from at least one sensor configured to sense physical activity in a building in which medication of a patient is located is monitored and a determination is made to capture one or more images of the medication based on the monitoring. A camera is used to capture an image of the medication and the captured image is analyzed to detect a state of the medication. Information regarding a schedule by which the medication should be taken by the patient is accessed and an expected state of the medication is determined. The detected state is compared with the expected state and a determination is made that the patient has departed from the schedule based on the comparison revealing that the detected state does not match the expected state. A message indicating the departure from the schedule is sent based on the determination.

Method and system for detecting electrophysiological changes in pre-cancerous and cancerous breast tissue and epithelium

A method and system are provided for determining a condition of a selected region of epithelial and stromal tissue in the human breast. A plurality of measuring electrodes are used to measure the tissue and transepithelial electropotential of breast tissue. Surface electropotential and impedance are also measured at one or more locations. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. The condition of the tissue is determined based on the electropotential and impedance profile at different depths of the epithelium, stroma, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue. Devices for practicing the disclosed methods are also provided.

Ventilation mask with integrated piloted exhalation valve

In accordance with the present invention, there is provided a mask for achieving positive pressure mechanical ventilation (inclusive of CPAP, ventilator support, critical care ventilation, emergency applications), and a method for a operating a ventilation system including such mask. The mask of the present invention includes a piloted exhalation valve that is used to achieve the target pressures/flows to the patient. The pilot for the valve may be pneumatic and driven from the gas supply tubing from the ventilator. The pilot may also be a preset pressure derived in the mask, a separate pneumatic line from the ventilator, or an electro-mechanical control. The mask of the present invention may further include a heat and moisture exchanger (HME) which is integrated therein.

Devices, systems and methods to analyze evoked responses to pre-pacing pulses to predict imminent vt/vf, estimate ischemic burden and/or characterize electrical substrates

Described herein are implantable systems, and methods for use therewith, to predict whether ventricular tachycardia (VT) or ventricular fibrillation (VF) is imminent, estimate ischemic burden and/or characterize an electrical substrate of the LV chamber. For each of a plurality of cardiac cycles, a pacing vector comprising a first set of electrodes is used to deliver a pre-pacing pulse at a site within the LV chamber (wherein the pre-pacing pulse is delivered prior to an intrinsic activation of the LV chamber), and a sensing vector comprising a second set of electrodes is used to detect an evoked response to the pre-pacing pulse. The detected evoked responses to the pre-pacing pulses are analyzed, and results of the analysis are used predict whether VT or VF is imminent, estimate ischemic burden and/or characterize an electrical substrate of the LV chamber.

Systems and methods for non-contact multiparameter vital signs monitoring, apnea therapy, apnea diagnosis, and snore therapy

Aspects of the of the disclosure relate to a non-contact physiological motion sensor and a monitor device that can incorporate use of the Doppler effect. A continuous wave of electromagnetic radiation can be transmitted toward one or more subjects and the Doppler-shifted received signals can be digitized and/or processed subsequently to extract information related to the cardiopulmonary motion in the one or more subjects. The extracted information can be used, for example, to determine apneic events and/or snoring events and/or to provide apnea or snoring therapy to subjects when used in conjunction with an apnea or snoring therapy device. In addition, methods of use are disclosed for sway cancellation, realization of cessation of breath, integration with multi-parameter patient monitoring systems, providing positive providing patient identification, or any combination thereof.

Multidirectional microfluidic drug delivery devices with conformable balloons

The methods, systems, and devices disclosed herein generally involve convection-enhanced delivery of drugs to a target region within a patient. Microfluidic catheter devices are disclosed that are particularly suitable for targeted delivery of drugs via convection, including devices capable of multi-directional drug delivery, devices that control fluid pressure and velocity using the venturi effect, and devices that include conformable balloons. Methods of treating various diseases using such devices are also disclosed, including methods of treating cerebral and spinal cavernous malformations, cavernomas, and hemangiomas, methods of treating neurological diseases, methods of treatment using multiple microfluidic delivery devices, methods of treating hearing disorders, methods of spinal drug delivery using microfluidic devices, and methods of delivering stem cells and therapeutics during fetal surgery. Methods of manufacturing such devices are also disclosed.

Systematic distillation of status data relating to regimen compliance

Configuration technologies for cost-effectively monitoring indicia of regimen compliance or noncompliance in response to one or more indications of symptoms or actions or other data on data-bearing media or in wireless transmissions, such as implementing techniques for providing or preventing access or otherwise acting on or communicating incremental or definitive indicia of compliance or noncompliance.

Devices and methods for recording information on a subject's body

Embodiments disclosed herein relate to methods, devices, and computer systems thereof for visibly or non-visibly indicating a subject has received a medical treatment. In certain embodiments, a subject receives an information mark in conjunction with a medical treatment. In certain embodiments, the information mark includes unique information relating to the subject. In certain embodiments, devices, computer systems, and methods relate to reading an information mark on a subject, and optionally determining if further medical treatment of the subject is warranted. In certain embodiments, receipt of an information mark entitles a subject to a reward.

Space-efficient containment devices and method of making same

Containment devices and methods of manufacture and assembly are provided. In an embodiment, the device includes at least one microchip element, which includes a containment reservoir that can be electrically activated to open, and a first electronic printed circuit board (PCB) which comprises a biocompatible substrate. The first PCB may have a first side on which one or more electronic components are fixed and an opposed second side on which the microchip element is fixed in electrical connection to the one or more electronic components. The device may further include a second PCB and a housing ring securing the first PCB together with the second PCB. The microchip element may include a plurality of containment reservoirs, which may be microreservoirs, and/or which may contain a drug formulation or a sensor element.

Optical sensing systems and methods

An optical glucose sensor may include an optical fiber and a glucose-permeable membrane having a hollow interior and being coupled to the optical fiber's distal end. The membrane's hollow interior provides a compartment to house a competitive glucose binding affinity assay. The assay may include a glucose analog that may be labeled with a dye, and a glucose receptor that may be labeled with a fluorophore. The optical fiber may include a compound parabolic concentrator tip, and the compartment may additionally house a reflector disposed so as to face the optical fiber's tip. A fluorophore-labeled assay may be interrogated by an optical interrogating system including a light source and a filter substrate having one or more coatings to effect, e.g., an excitation filter and/or an emission filter. The interrogating system may be manufactured as a stacked planar integrated optical system and diced into smaller units.

DEVICE FOR EXAMINING NERVE FUNCTION

The present invention relates to a device for examining nerve function. In order to examine the function of a nerve of the human body, the device for examining nerve function of the present invention includes: at least one stimulator for stimulating the human body; and a stimulator-fixing member having a form corresponding to the hands or feet of the human body, wherein the stimulator is located at one side of the simulator-fixing member so as to fix the stimulator to the hands or feet of the human body. The device for examining nerve function of the present invention further includes at least one blood-circulation detection sensor fixed at the stimulator-fixing member. According to the present invention, since the degree of hypoesthesia is examined through the stimulation of the stimulator, test accuracy and reliability may be greatly improved and it is possible to systematically and actively determine a diagnosis and course of treatment for a patient having diabetes or spinal nerve damage, e.g. hypoesthesia. 1. A device for examining nerve function comprising:at least one stimulator for stimulating the human body to examine nerve function of the human body; anda stimulator fixing member formed in the shape corresponding to the hands or feet of the human body, wherein the stimulator is located at one side of the stimulator fixing member so as to fix the stimulator to the hands or feet of the human body.2. The device according to claim 1 , wherein the stimulator comprises at least one of a pressurizer for pressurizing the skin to provide stimulation and a vibrator for applying vibration-type stimulation to the skin.3. The device according to claim 2 , wherein the pressurizer comprises a hollow holder fixed at one side of the stimulator fixing member; and a stimulating pin inserted into a hollow which is formed inside the hollow holder and moving forward and backward in the hollow claim 2 , wherein the front end portion of the stimulating pin is moved to pressurize ...

HEALTH MONITORING APPLIANCE

A monitoring system for a person includes one or more wireless nodes; and a wearable patch or bandage appliance secured to the person' skin and in communication with the one or more wireless nodes, wherein the patch or bandage appliance monitors and transmits patient vital signs to the wireless nodes. 1. A monitoring system for a person , comprising:one or more wireless nodes; anda wearable patch or bandage appliance secured to the person' skin and in communication with the one or more wireless nodes, wherein the patch or bandage appliance monitors and transmits patient vital signs to the wireless nodes.2. The system of claim 1 , comprising an accelerometer to detect a dangerous condition and to generate a warning when the dangerous condition is detected.3. The system of claim 1 , comprising a cellular transceiver coupled to the appliance.4. The system of claim 1 , comprising one of: EKG detector claim 1 , ECG detector claim 1 , electromagnetic detector claim 1 , ultrasonic detector claim 1 , optical detector claim 1 , a Hidden Markov Model (HMM) recognizer claim 1 , a dynamic time warp (DTW) recognizer claim 1 , a neural network claim 1 , a fuzzy logic engine.5. The system of claim 1 , wherein the appliance monitors patient movement.6. The system of claim 1 , comprising an in-door positioning system coupled to one or more network appliances to provide location information.7. The system of claim 1 , comprising a call center coupled to the appliance to provide a voice response.8. The system of claim 1 , comprising a web server coupled to the wireless nodes to provide information to an authorized remote user.9. The system of claim 1 , comprising a heart disease recognizer to detect arrhythmia.10. The system of claim 1 , comprising code to store and analyze patient information.11. The system of claim 1 , comprising code to store medicine taking habits claim 1 , eating and drinking habits claim 1 , sleeping habits claim 1 , or exercise habits.12. The system of claim 1 , ...

System for use in administering inhaled nitric oxide gas

Disclosed are systems for use in administering inhaled nitric oxide gas as a therapeutic treatment, where the systems reduce the risk of inducing an increase in pulmonary capillary wedge pressure leading to pulmonary edema in neonatal patients who have hypoxic respiratory failure and are candidates for inhaled nitric oxide treatment, the system comprising a source of pharmaceutically acceptable nitric oxide gas for inhalation, a delivery device suitable for delivering nitric oxide gas from the source to a term or near-term neonate patient, and instructions for use in operating the system.

System and Method for Monitoring Time Intervals During Blood Parameter Monitoring

A system and method for monitoring at least one blood parameter of the blood of different patients, comprising a plurality of access devices for establishing at least one means of access to the blood of each patient through the skin, a plurality of removal devices for removing a quantity of blood from each patient in order to obtain at least one blood sample, at least one blood analysis device for analysing the blood sample with respect to predeterminable blood parameters and for generating individual blood parameter data sets, a calculation device which can be used jointly for a plurality of blood parameter data sets of different patients for calculating data sets of drug parameters of the drugs to be administered to the respective patient on the basis of the individual blood parameter data sets, and a plurality of supply devices for supplying the respective drug having the calculated drug parameters.

INTRAOCULAR PHYSIOLOGICAL SENSOR

An implantable intraocular physiological sensor for measuring intraocular pressure, glucose concentration in the aqueous humor, and other physiological characteristics. The implantable intraocular physiological sensor may be at least partially powered by a fuel cell, such as an electrochemical glucose fuel cell. The implantable intraocular physiological sensor may wirelessly transmit measurements to an external device. In addition, the implantable intraocular physiological sensor may incorporate aqueous drainage and/or drug delivery features. 1. An implantable physiological measurement device comprising:a sensing module configured to measure a physiological characteristic of an organism; anda fuel cell configured to produce power using a substance found in the organism, wherein the fuel cell is configured to supply operating power to one or more components provided in the device.2. The device of claim 1 , wherein the fuel cell is an electrochemical fuel cell that provides electrical power to the one or more components provided in the device.3. The device of claim 2 , wherein the device is configured to be implanted in an eye.4. The device of claim 3 , wherein the electrochemical fuel cell comprises a glucose fuel cell.5. The device of claim 4 , wherein the sensing module is configured to measure intraocular pressure or glucose concentration in the aqueous humor of the eye.6. The device of claim 5 , wherein the sensing module is configured to measure glucose concentration based on the amount of electrical power produced by the fuel cell.7. The device of claim 1 , wherein the physiological characteristic corresponds to the amount of the substance used by the electrochemical fuel cell to produce electrical power.8. The device of claim 1 , wherein the one or more components comprise a transmitter and antenna configured to wirelessly transmit measurements from the sensing module to an external device claim 1 , and wherein the transmitter is configured to be at least ...

METHODS AND APPARATUSES FOR THE LOCALIZATION AND TREATMENT OF CANCER

Embodiments of the present invention provide methods of detecting cancer, methods of treating cancer using targeted hyperthermia, methods of treating cancer using targeted chemical agents, methods of treating cancer comprising accurate measurements of the efficacy of treatments. The effect of nanoparticles on magnetic fields can be used to determine the location of a tumor, and a measure of the number of cells in the tumor. This location and measure can be used to guide therapy, and provide information regarding the most effective therapy to be applied. The same nanoparticles can be used to facilitate hyperthermia treatments, and to allow targeted application of chemical therapeutic agents. 1. A method of treating cancer claim 2 , comprising (a) determining the location and number of cells in a tumor according to claim 2 , and (b) applying a therapy to the patient.2. A method for determining the location and number of cells in a tumor comprising introducing magnetic nanoparticles conjugated with biocompatible features that preferentially bind with features common to cells in the tumor claim 2 , subjecting the region of the tumor to a magnetic field claim 2 , measuring the effect of the nanoparticle/feature conjugates on the magnetic field claim 2 , determining the number of cells in the tumor from the magnitude of the effect claim 2 , and determining the location of the tumor by the location of the magnetic moment of the nanoparticle/feature conjugates bound to cancer cells.3. A method as in claim 2 , wherein the effect of the nanoparticle/feature conjugates on the magnetic field is determined by attenuating or removing the applied magnetic field and measuring the decay of the residual magnetic field.4. A method as in claim 1 , wherein step (b) comprises applying hyperthermia to the region of the tumor.5. A method as in claim 4 , wherein applying hyperthermia comprises applying an oscillating magnetic field to the region of the tumor claim 4 , wherein the ...

SIMULTANEOUS MULTI-MODALITY INVERSE OPTIMIZATION FOR RADIOTHERAPY TREATMENT PLANNING

When performing multimodal radiotherapy planning, an optimizer () concurrently optimizes a combined treatment plan that employs an intensity modulated radiotherapy (IMRT) device () and an intensity modulated proton therapy (IMPT) that respectively generate a photon beam and an ion beam for treating a volume of interest () in a patient (). A simulator () iteratively generates multiple variations of a simulation model () according to optimization parameters that are varied by the optimizer () until the simulation model () satisfies user-entered treatment objective criteria () (e.g., maximum dose, does placement, etc.) 1. A system that facilitates optimization of a multimodal radiation therapy plan employing both photon beam and ion beam radiation treatments , including: a display on which is presented to the user information related to one or more radiation treatment plan simulation models;', 'an optimizer that concurrently optimizes dose delivery from a photon therapy device and an ion therapy device in one or more simulation models by iteratively adjusting a plurality of optimization parameters for each of the photon therapy device and the ion therapy device during simulation; and, 'an input graphical user interface (GUI) that includesa simulator that generates the one or more simulation models according to the optimization parameters.2. The system according to claim 1 , wherein the optimizer identifies an optimal simulation model that satisfies predefined radiation treatment objective criteria.3. The system according to claim 1 , further including:a diagnostic scanner that acquires image data of a volume of interest in a patient to be treated using a combined photon and ion radiation treatment; anda reconstruction processor that reconstructs the acquired image data into one or more images that are used by the simulator to identify contours of the patient and the volume of interest to be treated.4. The system according to claim 1 , wherein the ion therapy device ...

APPARATUS AND METHOD FOR PREDICTION OF RAPID SYMPTOMATIC BLOOD PRESSURE DECREASE

A monitoring arrangement is configured to predict a rapid syruptomatic drop in a subject's blood pressure, e.g. during a medical treatment or when operating aircraft. To this aim, a pulse shape parameter (p) with respect to a peripheral body part () of the subject (P) is repeatedly registered by means of a pulse oximetry instrument () adapted to detect light response variations in blood vessels. A respective pulse magnitude measure is calculated based on each of a number of received pulse shape parameters (p), and a statistical dispersion measure is calculated based on the thus-calculated pulse magnitude measure. It is investigated whether or not the statistical dispersion measure fulfils a decision criterion relative to a reference measure. An output signal (α) is generated if the decision criterion is found to be fulfilled. 1. A monitoring arrangement for predicting rapid symptomatic blood pressure decrease in a subject , the arrangement comprising:a pulse apparatus configured to repeatedly register a pulse shape parameter in a peripheral body part of the subject, wherein the pulse recording apparatus means comprises a pulse oximetry instrument configured to register the pulse shape parameter based on light response variations in at least one blood vessel of the subject, anda control unit configured to receive the pulse shape parameter, the control unit comprising a processing unit configured adapted to:calculate, during a measurement period, a respective pulse magnitude measure based on each of a number of received pulse shape parameters,calculate a statistical dispersion measure from the pulse magnitude measures,investigate whether the statistical dispersion measure fulfils a decision criterion relative to a reference measure, andgenerate an output signal indicating a prediction of said rapid symptomatic blood pressure decrease in the subject.2. The arrangement according to claim 1 , wherein the statistical dispersion measure is any of variance claim 1 , ...

Method of monitoring safety in medication delivery for diabetes management

Glucose sensor signals and medication delivery control signals are monitored and these signals are modified for compatibility and safety purposes. In one application, output control signals from a controller directed to a delivery device are modified as a function of an actual amount of insulin delivered to the user. The safety layer method allows for an increased level of safety in an integrated delivery management (“IDM”) system and permits the development of separate hardware and software upgrades for components of the IDM system while assuring that compatibility between components will continue and safety is increased.

GLYCEMIC HEALTH METRIC DETERMINATION AND APPLICATION

Disclosed are methods, apparatuses, etc. for determination and application of a metric for assessing a patient's glycemic health. In one particular implementation, a computed metric may be used to balance short-term and long-term risks associated with a particular therapy. 1. A method comprising:at a special purpose computing apparatus, computing a profile of a blood glucose concentration of a patient based, at least in part, on observations of said blood glucose concentration collected at a blood glucose monitoring device, said profile comprising at least a computed mean blood glucose concentration and an indication of a statistical dispersion;applying a cost or loss function to said computed profile to compute a metric representative of a glycemic health of the patient, said cost or loss function being based, at least in part, on an application of a log-square operation to at least one of the computed mean or said indication of said statistical dispersion; andaffecting a therapy applied to said patient based, at least in part, on said computed metric.2. The method of claim 1 , wherein said indication of said statistical dispersion comprises a standard deviation.3. The method of claim 1 , wherein said metric comprises a unidimensional metric.4. The method of claim 1 , wherein affecting said therapy comprises setting a target blood glucose level or target blood glucose range of said patient based claim 1 , at least in part claim 1 , on said computed metric.5. The method of claim 1 , wherein said loss or cost function is further based claim 1 , at least in part claim 1 , on application of a log-square function to a target blood glucose concentration value.6. The method of claim 5 , wherein said metric substantially has the form:{'br': None, 'i': G', 'G, 'sub': T', '10', '10', 'T, 'sup': 2', '2, 'Loss()=log(σ)+[log 10(μ)−log()], where{'sub': 'T', 'Gis the target blood glucose concentration value;'}μ is the computed mean; andσ is the measure of the statistical ...

MRI-Guided Medical Interventional Systems and Methods

An MRI-guided interventional system includes a trajectory guide frame for guiding an interventional device with respect to a patient in an MRI-guided procedure and including a base, a platform, a targeting cannula, and a stabilizer mechanism. The platform is mounted on the base and includes a support table and a moving plate that is translatable relative to the support table and the base along a translational axis. The targeting cannula is mounted on the moving plate for movement therewith and includes an elongate guide bore defining a trajectory axis. The stabilizer mechanism is operable to selectively control movement between the support table and the moving plate to stabilize a position of the targeting cannula with respect to the base. The frame is operable to translate the moving plate along the translational axis relative to the base to position the trajectory axis. The translational axis is transverse to the trajectory axis. 1. An MRI-guided interventional system for use with a body of patient and an interventional device , the system including: a base having a patient access aperture therein, wherein the base is configured to be secured to the body of the patient;', 'a platform mounted on the base and including a support table and a moving plate that is translatable relative to the support table and the base along a translational axis;', 'a targeting cannula mounted on the moving plate for movement therewith relative to the support table and the base, the targeting cannula including an elongate guide bore therethrough, the guide bore defining a trajectory axis and being configured to guide placement of the interventional device in vivo; and', 'a stabilizer mechanism operable to selectively control movement between the support table and the moving plate to stabilize a position of the targeting cannula with respect to the base;', 'wherein the trajectory guide frame is operable to translate the moving plate and thereby the targeting cannula along the ...

System and method for diagnosing and treating psychiatric disorders

Systems and methods for diagnosing and treating psychiatric disorders are provided. For example, in one embodiment, the systems and methods generally include: (a) presenting an emotional conflict task to a patient; (b) receiving an input from the patient in response to the emotional conflict task; (c) assessing the patient's response to the emotional conflict task; and (d) modifying the emotional conflict task based on the patient's response. Such systems and methods may also be employed in a computerized training system for treating a patient with, or at risk of, a psychiatric disorder by training the patient's implicit emotional regulation.

SYSTEMS AND METHODS FOR PULMONARY MONITORING AND TREATMENT

Systems and methods are disclosed determining a pulmonary function by mounting one or more sensors intra-orally; capturing intra-oral data; and determining the pulmonary function based on an analysis of the intra-oral data. 1. A method for determining a pulmonary function of a patient , comprising:a. mounting one or more sensors intra-orally upon at least one tooth via an intra-oral appliance, wherein the appliance produces an interference fit between the appliance and at least two surfaces of at least one tooth;b. capturing intra-oral data via the one or more sensors; andc. determining the pulmonary function based on an analysis of the intra-oral data.2. The method of claim 1 , further comprising determining an intermittent breathing condition from an intra-oral sound captured by the one or more sensors or determining a snoring condition from the intra-oral sound.3. The method of claim 1 , wherein mounting further comprises providing the appliance having an actuatable transducer disposed Within or upon a housing of the appliance.4. The method of claim 3 , wherein after determining the pulmonary function claim 3 , maintaining contact between a surface of the at least one tooth and the actuatable transducer such that the transducer transmits vibrations to a surface of the at least one tooth.5. The method of claim 1 , wherein capturing comprises:a. measuring a magnitude and a frequency of an intra-oral sound; andb. determining one or more intervals between breaths from the intra-oral sound.6. The method of claim 1 , wherein capturing comprises measuring oxygen concentration or carbon dioxide saturation.7. The method of claim 1 , wherein capturing comprises measuring oxygen data through a lax stratum corneum or a dermal structure.8. The method of claim 1 , wherein capturing comprises performing claim 1 , a dual-color ratiometric oxygen saturation measurement.9. The method of claim 1 , wherein capturing comprises measuring breath oxygen or carbon dioxide content.10. The ...

Method and/or system for multicompartment analyte monitoring

Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.

Polar plot to represent glucose sensor performance

Disclosed are methods, apparatuses, etc. for providing a visual expression of the performance of one or more blood glucose sensors. In one particular example, a relative comparison of a rate of change sensor blood glucose and a rate of change in reference blood glucose may be expressed in a polar plot or graph. The polar plot or graph may then be generated onto a visual medium.

ELECTROANATOMICAL MAPPING

This invention relates to the determination and/or representation of physiological information relating to a heart surface. 175-. (canceled)76. A method for providing an electroanatomical representation of a patient's heart , the method comprising:measuring signals at one or more electrodes at multiple positions in the patient's heart cavity over a time period including multiple heart beat cycles, at least some of the signals being in response to electrical activity in the patient's heart cavity;selecting portions of one or more specific signals to process to determine a triggering event based on a second, different signal of the measured signals;applying an algorithm to the selected portions of the one or more specific signals of the measured signals to determine the triggering event in the specific signal;synchronizing, by the computer, the signals measured at the one or more electrodes with one another according to a heart beat cycle based on the triggering event; andgenerating, by the computer, the electroanatomical representation of the patient's heart based on the synchronized measured signals and positions of the catheter electrodes.77. (canceled)78. The method of claim 76 , wherein selecting portions of the specific signal comprises selecting portions of the specific signal to exclude from processing.79. The method of claim 76 , wherein selecting portions of the specific signal comprises selecting portions of the specific signal to include in processing.8084-. (canceled)85. The method of claim 76 , wherein the one or more electrodes comprise one or more electrodes on an intracardiac catheter.86. The method of claim 76 , further comprising:generating, by the computer, annotation information for the measured signals by applying one or more algorithms to the measured signals.87. The method of claim 86 , further comprising conveying at least some of the annotation information to the user.88. The method of claim 76 , further comprising:inserting a catheter ...

APPARATUS, SYSTEM, AND METHOD FOR SEIZURE SYMPTOM DETECTION

An apparatus, system, and method are disclosed for detecting seizure symptoms in an individual . A sensor module receives physiological data for an individual from one or more sensors , such as a heart activity sensor. A feature detection module detects a predefined feature in the physiological data. The predefined feature is associated with a seizure or another medical condition. An alert module broadcasts an alert in response to the feature detection module detecting the predefined feature 1. An apparatus to detect seizure symptoms , the apparatus comprising:a sensor module that receives heart activity data for an individual from a heart activity sensor;a feature detection module that detects a predefined feature in the heart activity data, the predefined feature associated with a seizure; andan alert module that broadcasts an alert in response to the feature detection module detecting the predefined feature.2. The apparatus of claim 1 , further comprising a confirmation feature module that detects one or more additional predefined features associated with a seizure in additional data for the individual from one or more additional sensors claim 1 , wherein the sensor module receives the additional data from the one or more additional sensors and wherein the alert module broadcasts the alert in response to the confirmation feature module detecting the one or more additional predefined features.3. The apparatus of claim 2 , wherein the one or more additional sensors include a respiration sensor and the one or more additional predefined features comprise one or more of a predefined increase in an integrated respiration waveform claim 2 , a predefined increase in respiration amplitude claim 2 , a predefined change in respiration rate claim 2 , a breath of at least a predefined duration claim 2 , a breath of at least a predefined amplitude claim 2 , a breath of at least a predefined volume claim 2 , and a predefined change in a period of a respiration interval.4. The ...

Analyte Monitoring Device and Methods of Use

In aspects of the present disclosure, a multi compatible or universal blood glucose monitoring unit including a calibration unit is integrated with one or more components of an analyte monitoring system to provide compatibility with in vitro test strip that require calibration code and test strips that do not require calibration code. Also disclosed are methods, systems, devices and kits for providing the same. 1. A component of an in vivo continuous glucose monitoring system that determines glucose level by way of in vivo glucose sensors and in vitro glucose test strips , comprising:a test strip receiving port that receives coded in vitro glucose test strips that require user calibration action to calibrate the test strip and no-coded in vitro glucose test strips that do not require user calibration action to calibrate the test strip;a processor programmed to determine glucose concentration from electrical signal obtained from in vivo glucose sensors at least partially inserted into the skin of a user, and from both coded and non-coded in vitro glucose test strips received in the test strip receiving port by first determining if a received in vitro glucose test strip is a coded or non-coded test strip, selecting a coded or non-coded processing algorithm to process the signal once determined, and processing the signal to determine an in vitro glucose value; anda user interface configured to communicate glucose level determined by the processor.2. The component of claim 1 , further comprising programming to automatically determine if a received in vitro glucose test strip is a coded or a non-coded test strip.3. The component of claim 1 , further comprising user-selectable inputs that identify a received in vitro glucose test strip as a coded or a non-coded test strip.4. The component of claim 1 , wherein the processor is programmed to generate a request for a calibration code if a coded test strip is received in the test strip port.5. The component of claim 1 , ...

Self-Assembled, Micropatterned, and Radio Frequency (RF) Shielded Biocontainers and Their Uses for Remote Spatially Controlled Chemical Delivery

The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the particle, with subsequent release of the therapeutic materials in situ, methods of fabricating the particle by folding a 2D precursor into the 3D particle, and the use of the particle in in-vivo or in-vitro applications The particle can be in any polyhedral shape and its surfaces can have either no perforations or nano/microscale perforations The particle is coated with a biocompatible metal, e g gold, or polymer e g parvlene, layer and the surfaces and hinges of the particle are made of any metal or polymer combinations. 139-. (canceled)40. A method for imaging a three-dimensional particle or biocapsule that has been implanted into a subject , wherein the three-dimensional particle or biocapsule comprises a plurality of two-dimensional faces capable of self-folding to form a hollow interior , wherein a size of the particle or biocapsule is microscale or nanoscale , and wherein the plurality of two-dimensional faces comprise a folding hinge between two adjacent faces and a locking or sealing hinge on an edge of a two-dimensional face , wherein the folding hinge between two adjacent faces has a width that is about twice a width of the locking or sealing hinge on an edge , wherein the plurality of two-dimensional faces comprising the three-dimensional particle or biocapsule are permanently held together by solid hinges; (i) loading the hollow interior of the particle or biocapsule with at least one substance to form a loaded particle or biocapsule;', '(ii) administering the loaded particle or biocapsule to the subject; and', '(iii) noninvasively tracking the particle or biocapsule of step (ii) in the subject by magnetic resonance imaging or CAT scan (CT)., 'the method comprising41. The method according to claim 40 , wherein the particle or biocapsule ...

THREE-DIMENSIONAL THERMAL IMAGING FOR THE DETECTION OF SKIN LESIONS AND OTHER NATURAL AND ABNORMAL CONDITIONS

A thermal imaging system includes a data processing system and a geometrical scanning system constructed to communicate with the data processing system. The geometrical scanning system is adapted to scan at least a section of a surface of a subject under observation. The thermal imaging system also includes an infrared imaging system constructed to communicate with the data processing system. The infrared imaging system is adapted to image at least a portion of the section of the surface of the subject under observation. The data processing system is configured to receive data from the geometrical scanning system and to construct a surface map of the section of the surface of the subject under observation and to identify geometrical markers on the surface map based on the data from the geometrical scanning system. The data processing system is also configured to receive data from the infrared imaging system and to construct a thermal map of the portion of the section of the surface, to identify thermal markers on the thermal map based on the data from the infrared imaging system, and to register the thermal map to the surface map based on a correspondence between at least some of the geometrical and thermal markers. The data processor is configured to correct temperatures of the thermal map based on the surface map subsequent to the registering. 1. A thermal imaging system , comprising:a data processing system;a geometrical scanning system constructed to communicate with said data processing system, said geometrical scanning system being adapted to scan at least a section of a surface of a subject under observation; andan infrared imaging system constructed to communicate with said data processing system, said infrared imaging system being adapted to image at least a portion of said section of said surface,wherein said data processing system is configured to receive data from said geometrical scanning system and to construct a surface map of said section of said ...

USE OF DRONEDARONE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF FOR THE PREPARATION OF A DRUG FOR THE PREVENTION OF ATRIAL FIBRILLATION

The present invention relates to the use of dronedarone or a pharmaceutically acceptable salt thereof for the preparation of a drug for the prevention of atrial fibrillation wherein said use comprises the following precaution of use steps: 1. A method of preventing atrial fibrillation in a patient with a history of paroxysmal or persistent atrial fibrillation or atrial flutter , comprising:a) initiating dronedarone administration in said patient, andb) performing electrocardiograms of said patient serially.2. The method according to claim 1 , further comprising:c) discontinuing dronedarone administration if the patient develops permanent atrial fibrillation or if symptomatic atrial fibrillation reoccurs.3. The method according to claim 1 , further comprising:c) discontinuing dronedarone administration or cardioverting said patient if atrial fibrillation is detected.4. The method according to claim 1 , further comprising preventing cardiovascular hospitalization.5. The method according to claim 1 , further comprising preventing hospitalization for atrial fibrillation.6. The method according to claim 1 , wherein said prevention of atrial fibrillation is maintenance of sinus rhythm.7. The method according to claim 1 , wherein said patient has non permanent atrial fibrillation or atrial flutter.8. The method according to claim 1 , wherein said patient does not have permanent atrial fibrillation or flutter with additional cardiovascular risk factors.9. The method according to claim 1 , wherein said patient does not have permanent atrial fibrillation nor a history of claim 1 , or current heart failure.10. The method according to claim 1 , wherein said patient does not have permanent atrial fibrillation nor symptomatic heart failure with recent decompensation requiring hospitalization.11. The method according to claim 1 , wherein said patient does not have permanent atrial fibrillation nor heart failure defined as NYHA class IV.12. The method according to claim 1 , wherein ...

Surgical instrument having force feedback capabilities.

A surgical instrument. The surgical instrument has a force delivery system which communicates a changing force to a user of the surgical instrument when a limit of a surgical function is reached. A sensor senses position of a moving element to communicate a signal to the force delivery system. In various embodiments, the system generates a vibratory force to signal the user.

Medical device comprising a multipart housing

A medical device for carrying out at least one medical function, comprising at least one element that can be at least partially inserted into a body tissue of a user and further comprising at least one housing that can be placed on a skin surface of the user. The housing has a multipart design and comprises at least one functional component. The functional component can be connected to the insertable element. The housing further comprises at least one protective component. The protective component is designed to at least partially enclose the functional component. The protective component can be connected to the functional component, particularly after insertion of the insertable element.

Methods and systems for in vivo clinical data measurement of analytes

The present invention provides apparatuses, systems, and methods for real-time measuring of analytes in a biological fluid sample of a subject. In particular, the present invention provides a combination of micro-dialysis catheter, a micro-volume pump, and a spectrometer device that are operatively connected to one another to provide real-time measurement of analytes in a biological fluid sample of a subject.

PLANNING SYSTEM FOR TARGETING TISSUE STRUCTURES WITH ULTRASOUND

The disclosed subject matter provides systems and methods for targeting tissue structures and applying ultrasound thereto. A method according to the disclosed subject matter for targeting a tissue structure using corresponding tissue structure image data includes inputting the tissue structure image data into a targeting simulator, determining acoustic properties of the tissue structure from the corresponding tissue structure image data, and utilizing the determined acoustic properties to align a simulated transducer with the tissue structure such that the tissue structure is targeted. The method can further include acquiring the tissue structure image data, aligning the image data with an atlas of a body structure encompassing the tissue structure and/or selecting parameters of the simulated transducer such that a focal region of an ultrasound wave generated by the simulated transducer targets the tissue structure. 1. A method for targeting a tissue structure using corresponding tissue structure image data , comprising:receiving the tissue structure image data into a targeting simulator;determining one or more acoustic properties of the tissue structure from the corresponding tissue structure image data; andutilizing the determined one or more acoustic properties to align a simulated transducer with the tissue structure such that the tissue structure is targeted.2. The method of claim 1 , further comprising acquiring the tissue structure image data.3. The method of claim 2 , wherein the acquiring comprises acquiring a CT scan of at least the tissue structure.4. The method of claim 2 , wherein the acquiring comprises acquiring an MRI of at least the tissue structure.5. The method of claim 1 , further comprising aligning the tissue structure image data with an atlas of a body structure encompassing the tissue structure.6. The method of claim 1 , further comprising selecting parameters of the simulated transducer such that a focal region of an ultrasound wave ...

APNEA TYPE DETERMINING APPARATUS AND METHOD

An apnea classification system provides for apnea monitoring and differentiation based on several sleep apnea related parameters for diagnostic and therapeutic purposes. Monitoring of such sleep apnea related parameters allows the apnea classification system to differentiate among the different types of apnea and hypopnea and to identify an occurrence of periodic respiration. This information may then be used to determine the best method of therapy, or adjust current therapy parameters to more effectively treat a subject. 1. A system comprising:a respiration-based sensor configured to receive information indicative of inhalation or exhalation;a non-respiration-based sensor configured to receive information other than information indicative of inhalation or exhalation; andan apnea detection module, coupled to the respiration-based and non-respiration-based sensors, configured to recognize an apnea using information from both the respiration-based and non-respiration-based sensors.2. The system of claim 1 , wherein the respiration-based sensor is configured to receive cyclic information indicative of inhalation or exhalation claim 1 , and wherein the apnea detection module is configured to recognize the apnea using the cyclic information.3. The system of claim 2 , wherein the non-respiration-based sensor is configured to receive information other than cyclic information claim 2 , and wherein the apnea detection module is configured to recognize the apnea using the information other than the cyclic information.4. The system of claim 1 , wherein the respiration-based sensor includes an impedance sensor configured to detect impedance information that is indicative of inhalation or exhalation.5. The system of claim 1 , wherein the respiration-based sensor includes a blood pressure sensor configured to detect blood pressure information that is indicative of inhalation or exhalation.6. The system of claim 1 , wherein the non-respiration-based sensor includes a blood ...

METHOD AND SYSTEM TO DISPLAY ANALYTE SENSOR DATA

Described and illustrated herein are an exemplary methods and system to display analyte sensor data. Such method may be achieved by the medical device receiving data from the analyte sensor for a period of time and displaying a target zone and a graphical representation of the data in which one or more portions of the graphical representation comprises a specific indicia of clinical risk. 1. A method of monitoring analyte concentrations of a user over time , the method comprising:determining with an analyte sensor that transforms signals of analyte concentrations in physiological fluid of the user over a period of time into determined analyte concentration data; anddisplaying a target zone of upper and lower analyte concentration thresholds, a first indicia representative of the determined analyte concentration data in the target zone, and a second indicia representative of the determined analyte concentration data outside of the target zone.2. The method of claim 1 , in which the displaying further comprises displaying a third indicia for at least one analyte concentration of the determined analyte concentration data below the target zone.3. The method of claim 1 , in which the target zone comprises a threshold value indicative of clinical risks arising from diabetes.4. The method of claim 2 , in which each of the first claim 2 , second and third indices comprises respective symbols.5. The method of claim 2 , in which each of the indices further comprises a color.6. The method of claim 1 , in which each of the indices comprises an icon.7. The method of claim 1 , in which the analyte sensor comprises a continuous glucose sensor.8. The method of claim 1 , in which the displaying comprises displaying a trend indicative symbol to represent a trend of determined analyte concentration data over a predetermined time frame.9. A system for diabetes management claim 1 , the system comprising:an analyte sensor configured to transmit data transformed from a user's signals ...

ANALYTE MONITORING SYSTEM AND METHODS OF USE

The present disclosure provides methods of processing data provided by a transcutaneous or subcutaneous analyte sensor utilizing different algorithms to strike a balance between signal responsiveness accompanied by signal noise and the introduction of error associated with that noise. The methods utilize the strengths of a lag correction algorithm and a smoothing algorithm to optimize the quality and value of the resulting data (glucose concentrations and the rates of change in glucose concentrations) to a continuous glucose monitoring system. Also provided are systems and kits. 1. A method for monitoring an analyte , comprising:monitoring a data stream including a set of contiguous source data points related to the concentration of an analyte;providing one or more sets of maximum lag corrected signals from the one or more sets of monitored data stream, wherein each set of maximum lag corrected signals is generated utilizing correction terms based on time derivative estimates and historical monitored data stream, and wherein parameters for the maximum lag correction minimize the correlation between the expected glucose error and time derivative estimates and minimize the correlation between the expected glucose error and a pre-determined array of historical monitored data stream;providing one or more sets of maximum smoothing signals from the set of monitored data stream, wherein each set of maximum smoothing signals is generated utilizing a smoothing algorithm;determining analyte concentration utilizing the one or more sets of maximum lag corrected signals; anddetermining a rate of change in the analyte concentration utilizing the one or more sets of maximum smoothing signals.2. The method of claim 1 , wherein providing the one or more sets of maximum lag corrected signals includes utilizing an aggressive lag correction algorithm claim 1 , the lag correction algorithm configured to drive one or more of the correlation between the expected glucose error and the time ...

SYSTEM AND METHOD FOR ESTIMATING ELECTRICAL CONDUCTION DELAYS FROM IMMITTANCE VALUES MEASURED USING AN IMPLANTABLE MEDICAL DEVICE

Techniques are provided for estimating electrical conduction delays with the heart of a patient based on measured immittance values. In one example, impedance or admittance values are measured within the heart of a patient by a pacemaker or other implantable medical device, then used by the device to estimate cardiac electrical conduction delays. A first set of predetermined conversion factors may be used to convert the measured immittance values into conduction delay values. In some examples, the device then uses the estimated conduction delay values to estimate LAP or other cardiac pressure values. A second set of predetermined conversion factors may be used to convert the estimated conduction delays into pressure values. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP. 1. A system for estimating cardiac pressure within a patient using an implantable medical device , the system comprising:an immittance detection system operative to detect a value representative of electrical immittance within the heart of the patient; andan immittance-based electrical conduction delay estimation unit operative to estimate an electrical conduction delay in the heart of the patient from the value representative of immittance.2. The system of further including a conduction delay-based cardiac pressure estimation unit operative to estimate cardiac pressure within the patient from the estimated electrical conduction delay. This application is a Divisional application of and claims priority and other benefits from U.S. patent application Ser. No. 12/127,963 (Attorney Docket No. A08P3008), filed May 28, 2008, entitled “SYSTEM AND METHOD FOR ESTIMATING ELECTRICAL CONDUCTION DELAYS FROM IMMITTANCE VALUES MEASURED USING AN IMPLANTABLE MEDICAL DEVICE”, incorporated herein by reference in its entirety.This application claims priority on U.S. patent application Ser. No. 11/779,350, of Wenzel et al., filed Jul. 18, 2007, entitled, “System and ...

SYSTEM AND METHOD FOR SYSTOLIC INTERVAL ANALYSIS

A system and method provide for systolic interval analysis. In an example, an implantable device measures a cardiac impedance signal. A transformation of the cardiac impedance interval is generated. The device also measures a heart sound signal. A time interval between a point on the transformed signal of the cardiac impedance signal and a point on the heart sound signal is calculated. 1. A processor-readable medium , comprising instructions that , when performed by the processor , cause the processor to:obtain information indicative of an acoustic signal from an implantable acoustic sensor;identify a first heart sound feature in the information indicative of the acoustic signal;obtain information indicative of a cardiac impedance from an implantable cardiac impedance sensor;transform the information indicative of the cardiac impedance to obtain transformed cardiac impedance information;identify a first cardiac impedance feature in the transformed cardiac impedance information;determine a first interval between the identified first heart sound feature in the information indicative of the acoustic signal and the identified first cardiac impedance feature in the transformed cardiac impedance information; anddetermine a heart failure decompensation status using information about the determined first interval.2. The processor-readable medium of claim 1 , wherein the first interval corresponds to a left ventricular ejection time (LVET) claim 1 , and wherein the instructions include instructions that claim 1 , when performed by the processor claim 1 , cause the processor to:determine a second interval corresponding to a pre-ejection period (PEP);determine a relative indication of information between the PEP and the LVET; anddetermine the heart failure decompensation status using the relative indication of information.3. The processor-readable medium of claim 2 , wherein the instructions to determine the relative indication of information include instructions to determine ...

APPARATUS, SYSTEM AND METHOD FOR DETERMINING COMPLIANT USE OF AN INTRAORAL APPLIANCE

A compliance monitoring system () for an intraoral appliance comprises a power source (), a detector () for detecting when the intraoral appliance is positioned in the mouth for use, a recorder () configured to record measurement data, and a transponder () configured to communicate the measurement data. The monitoring system is adjustable based on a particular property of a patient or a group of patients. 240. The compliance monitoring system () of claim 1 , wherein the monitoring system is configured for being adjustable based on a unique characteristic of a patient or a group of patients.340. The compliance monitoring system () of claim 1 , wherein the particular property is a physical property including one or more of the group consisting of colour (gum claim 1 , teeth claim 1 , inside of cheek) claim 1 , teeth enamel claim 1 , temperature claim 1 , distance claim 1 , angle claim 1 , shape.440. The compliance monitoring system () of claim 1 , wherein the monitoring system claim 1 , preferably the detector claim 1 , comprises at least one signal emitter and/or at least one signal receiver.540. The compliance monitoring system () of claim 4 , wherein the signal emitter is a light emitter claim 4 , preferably an infrared-light emitter claim 4 , and wherein the signal receiver is a light receiver claim 4 , preferably an infrared-light receiver.640. The compliance monitoring system () of claim 4 , wherein the signal emitter is a sound emitter claim 4 , preferably an ultra sound emitter claim 4 , and wherein the signal receiver is a sound receiver claim 4 , preferably an ultra sound receiver.740. The compliance monitoring system () of claim 4 , wherein the signal emitter is a current emitter claim 4 , preferably a respectively driven electrode claim 4 , and wherein the signal receiver is a voltage receiver claim 4 , preferably respectively driven electrode.840. The compliance monitoring system () in accordance with claim 4 , wherein the at least one signal emitter and/ ...

Systems and Methods for Monitoring and Encouraging Patient Compliance

Systems and methods for providing information and queries regarding a medical condition to a patient may include receiving, by a processor, an enrollment request from the patient and collecting, by the processor, information about the patient. The enrollment request may include a keyword that corresponds to the medical condition. The systems and methods may further include enrolling, by the processor, the patient in a program that corresponds to the keyword and providing, by the processor, program information from the program to the patient. The program information may include information about the medical condition. The systems and methods may further include querying, by the processor, the patient about whether the patient has completed one or more tasks and based upon a response received from the patient, sending, by the processor, additional information to the patient. 1. A method for providing information and queries regarding a medical condition to a patient , the method comprising the steps of:receiving, by a processor, an enrollment request from the patient, wherein the enrollment request comprises a keyword that corresponds to the medical condition;collecting, by the processor, information about the patient;enrolling, by the processor, the patient in a program that corresponds to the keyword;providing, by the processor, program information from the program to the patient, wherein the program information comprises information about the medical condition;querying, by the processor, the patient about whether the patient has completed one or more tasks; andbased upon a response received from the patient, sending, by the processor, additional information.2. The method of claim 1 , further comprising the steps of:enrolling, by the processor, a caregiver in the program that corresponds to the keyword;providing, by the processor, the program information from the program to the caregiver;querying, by the processor, the caregiver about whether at least one of the ...

System and Method for Guidance of Anesthesia, Analgesia and Amnesia

Method for determining anesthesia dosage includes following steps. First Interventional Agent (“FIA”) is administered to Patient at a first rate to achieve First Predetermined Plane of Anesthesia (“FPPA”). Brain waves of Patient are analyzed to formulate First Set of Data (“FSD”) corresponding to a self-norm during administration of FIA. First transfer function corresponding to patient biochemical reactions to FIA is computed from FSD. Rate of administration of FIA to Patient is altered by a selected amount after achievement of FPPA for first time required for Patient to deviate from FPPA by predetermined degree. An altered amount of FIA required to cause the predetermined deviation is determined as difference between amount of FIA that would have been delivered to Patient during first time at the first rate and an amount delivered to Patient during the first time at the altered rate. Patient is administered the altered amount of FIA. 130.-. (canceled)31. A method of determining a desired anesthesia dosage for a patient via a perturbation analysis , comprising:administering to the patient a first interventional agent at a first rate selected to achieve a first predetermined plane of anesthesia;analyzing brain waves of the patient to formulate a first set of data corresponding to a self-norm during administration of the first interventional agent;computing from the first set of data a first transfer function corresponding to patient biochemical reactions to the first interventional agent;altering the rate of administration of the first interventional agent to the patient by a selected amount after achievement of the first plane of anesthesia for a first time required for the patient to deviate from the first plane of anesthesia by a predetermined degree;determining an altered amount of the first interventional agent required to cause the predetermined deviation from the first plane of anesthesia as a difference between an amount of the first interventional agent that ...

MAPPING SYSTEM AND METHOD FOR MEDICAL PROCEDURES

A system and method for mapping interluminal structures includes an elongated flexible instrument (). An optical shape sensing device () is disposed within the flexible instrument and is configured to determine a shape of the flexible instrument relative to a reference. The shape sensing device is configured to collect information based on its configuration to map an interluminal structure during a procedure. An imaging enabled ablation device () is mounted at or near a distal end portion of the flexible instrument. 1. A system for mapping interluminal structures , comprising:{'b': '102', 'an elongated flexible instrument ();'}{'b': 152', '154, 'an optical shape sensing device (, ) disposed within the flexible instrument and configured to determine a shape of the flexible instrument relative to a reference, the shape sensing device configured to collect information based on its configuration to map an interluminal structure during a procedure; and'}{'b': '117', 'an imaging enabled ablation device () mounted at or near a distal end portion of the flexible instrument.'}2152154154. The system as recited in claim 1 , wherein the optical shape sensing device includes an optical fiber () having at least one of Fiber Bragg Gratings (FBGs) () and a Rayleigh scatter interrogation setup () for sensing strain in the fiber.3152154. The system as recited in claim 1 , wherein the optical shape sensing device includes an area of higher sensitivity by including an area with a higher number of optical fibers () having optical strain sensors ().4. The system as recited in claim 1 , wherein the optical shape sensing device includes one of a spiral shape claim 1 , a ring shape and a loop shape.5. The system as recited in claim 1 , wherein the reference includes one of a position on the flexible instrument and an anatomical reference.6102. The system as recited in claim 1 , wherein the flexible instrument () includes one of a catheter and an endoscope.7. A system for mapping ...

INTUITIVE PRESENTATION OF VENTILATION EFFECTIVENESS

Ventilation information may be presented. Output signals may be received that convey information related to one or more breathing parameters of a subject receiving assisted or controlled mechanical ventilation. Based at least in part on the received output signals, volumetric components of a tidal volume of the subject may be determined. The volumetric components may include an alveolar dead space, an effective alveolar tidal volume, and/or other volumetric components. The alveolar dead space is the volume of inspired gas that occupies alveoli but does not take part in oxygen exchange in the lungs of the subject. The effective alveolar tidal volume is the volume of inspired gas that takes part in oxygen exchange in the lungs of the subject. A visual representation that textually or graphically represents the tidal volume, and/or textually or graphically represents the volumetric components separately from each other may be presented via a user interface. 1. A method for presenting ventilation information , the method comprising:receiving output signals conveying information related to one or more breathing parameters of a subject being mechanically ventilated;determining, based on the received output signals, volumetric components of a tidal volume of the subject, the volumetric components including (i) an alveolar dead space, and (ii) an effective alveolar tidal volume, the alveolar dead space being the volume of inspired gas that occupies alveoli but does not take part in oxygen exchange in the lungs of the subject, and the effective alveolar tidal volume being the volume of inspired gas that takes part in oxygen exchange in the lungs of the subject; andpresenting, via a user interface, a visual representation least a portion of a human respiratory system (i) that provides updated ventilation information in an ongoing manner and (ii) that textually or graphically represents the tidal volume and the volumetric components in a manner which makes analysis of (ii)(a) ...

SYSTEMS, DEVICES, AND METHODS FOR PROVIDING FOOT LOADING FEEDBACK TO PATIENTS AND PHYSICIANS DURING A PERIOD OF PARTIAL WEIGHT BEARING

Systems, devices, and methods for providing user feedback regarding compliance with a set of partial weight bearing (PWB) criteria are described. A computer system receives force data from a non-compressible force transmitter that is assigned to a user, and accesses the force data received from the non-compressible force transmitter to determine whether the user is within a predefined pressure compliance range. The pressure compliance range specifies a prescribed range of pressure that is to be applied during a PWB period. The computer system then receives a compliance data request from the user or the user's physician and communicates compliance data representing the user's compliance with the prescribed range of pressure during the PWB period to the user and/or the user's physician. 1. A system for providing user feedback regarding compliance with a set of partial weight bearing (PWB) criteria including a weight range and a prescribed number of steps , the system including:a receiving module that receives force data from a non-compressible force transmitter that is assigned to a user;a processing module that accesses the force data received from the non-compressible force transmitter to determine whether the user is within a predefined pressure compliance range, the pressure compliance range specifying a prescribed range of pressure that is to be applied during a PWB period; anda communications module that, upon receiving a compliance data request, communicates compliance data representing the user's compliance with the prescribed range of pressure during the PWB period to at least one of the user and the user's physician.2. The system of claim 1 , wherein the non-compressible force transmitter is positioned within a cavity of a housing oriented on the plantar surface of the user's foot.3. The system of claim 2 , wherein the non-compressible force transmitter is further positioned adjacent to a pressure sensor to transmit pressure within the housing.4. The system ...

INTEGRATED, HAND-HELD APPARATUS AND ASSOCIATED METHOD FOR ACQUIRING DIAGNOSTIC AND PROGNOSTIC INFORMATION FROM A PATIENT AT THE BEDSIDE OR AT SOME OTHER PATIENT LOCATION

An integrated, hand-held apparatus for acquiring diagnostic and prognostic information from a patient at the bedside or at some other patient location, the apparatus including a wand with a microphone for acquiring sound information from the patient and an ultrasound emitter/receiver for acquiring image data from the patient, a base unit including a speaker for presenting sound information to a user and a display for presenting image information to a user, and transferring the sound information acquired by the microphone and the image information acquired by the ultrasound emitter/receiver from the wand to the base unit. 1. An integrated , hand-held apparatus for acquiring diagnostic and prognostic information from a patient at the bedside or at some other patient location , the apparatus comprising: a microphone for acquiring sound information from the patient; and', 'an ultrasound emitter/receiver for acquiring image data from the patient; and, 'a wand comprising a speaker for presenting sound information to a user; and', 'a display for presenting image information to a user; and, 'a base unit comprisingtransferring means for transferring the sound information acquired by the microphone, and the image information acquired by the ultrasound emitter/receiver, from the wand to the base unit.2. Apparatus according to wherein the wand is releasably secured to the base unit.3. Apparatus according to wherein the base unit is configured to present sound information as image information on the display.4. Apparatus according to wherein the transferring means are configured to wirelessly transfer the sound information acquired by the microphone claim 1 , and the image information acquired by the ultrasound emitter/receiver claim 1 , from the wand to the base unit.5. Apparatus according to wherein the base unit comprises a base unit wireless transceiver claim 4 , the wand comprises a wand wireless transceiver claim 4 , and the wand wireless transceiver is configured to ...

MRI THERMAL IMAGING OF WATER TISSUE AND FAT TISSUE USING TRANSVERSE RELAXOMETRY DATA AND PROTON RESONANCE FREQUENCY SHIFT DATA

An apparatus () comprising a magnetic resonance imaging system (), the magnetic resonance imaging system comprising: a magnet () adapted for generating a magnetic field for orientating the magnetic spins of nuclei of a subject () located within an imaging volume (); a radio frequency transceiver () adapted for acquiring magnetic resonance data () using a radio frequency coil (); a computer system () comprising a processor (), wherein the computer system is adapted for controlling the apparatus; and a memory () containing machine readable instructions (), wherein execution of the instructions cause the processor to perform the steps of: acquiring () magnetic resonance data using the magnetic resonance imaging system, wherein the magnetic resonance data comprises transverse relaxometry data, and calculating () the temperature of the subject within a temperature measurement volume () in accordance with the transverse relaxometry data. 1. An apparatus comprising a magnetic resonance imaging system , the magnetic resonance imaging system comprising:a magnet adapted for generating a magnetic field for orientating the magnetic spins of nuclei of a subject located within an imaging volume;a radio frequency transceiver adapted for acquiring magnetic resonance data using a radio frequency coil;a magnetic field gradient coil adapted for spatial encoding of the magnetic spins of nuclei within the imaging volume;a magnetic field gradient coil power supply adapted for supplying current to the magnetic field gradient coil;a computer system comprising a processor, wherein the computer system is adapted for controlling the apparatus; and acquiring magnetic resonance data using the magnetic resonance imaging system, wherein the magnetic resonance data comprises transverse relaxometry T2 or T2 star data, as well as proton resonance frequency shift data, wherein at least the transverse relaxometry T2 or T2 star data is acquired using a turbo spin echo (TSE) sequence, and', 'calculating ...

Systems and methods for making and using medical ablation systems having mapping catheters with improved anchoring ability

A mapping catheter includes an elongated body for inserting into patient vasculature. A distal end of the elongated body includes a distal portion that includes a plurality of electrodes, a proximal portion disposed proximal to the distal portion, and a reduced-dimension portion disposed between the proximal and distal portions. The distal end is formed, at least in part, from a memory shape material that bends into a preformed shape upon release from a confined space. The preformed shape includes a first loop formed, at least in part, by the distal portion. The first loop is transverse to a longitudinal axis of the proximal portion. The reduced-dimension portion is configured and arranged to bend such that the reduced-dimension section advances distally through the first loop when the first loop is held in a fixed position and a force is applied distally along the longitudinal axis of the proximal portion.

MICROMACHINED NEURAL PROBES

A neural probe includes at least one shaft, at least one first electrode disposed on a first side of the at least one shaft, and at least one second electrode disposed on a second side of the at least one shaft. The at least one second electrode is separately addressable from the at least first electrode. 116.-. (canceled)17. A method of making a neural probe , comprising:providing a substrate having a thickness of 150 μm or less;patterning at least one first electrode on a first side of the substrate;attaching the substrate to a carrier;patterning the substrate into the neural probe comprising at least one shaft connected to a base; andremoving the neural probe from the carrier.18. The method of claim 17 , further comprising forming at least one second electrode on a second side of the substrate wherein the at least one second electrode is separately addressable from the at least one first electrode.19. The method of claim 17 , further comprising forming alignment marks through the substrate and using the alignment marks to align the at least one second electrode with the at least one first electrode.20. The method of claim 17 , further comprising forming a layer comprising Parylene claim 17 , silicon oxide claim 17 , silicon nitride or polyimide over the at least one first electrode claim 17 , forming a resist layer over the layer claim 17 , patterning the resist layer by electron beam or UV lithography claim 17 , and forming at least one opening in the layer to expose the at least one first electrode using the patterned resist layer as a mask.21. The method of claim 17 , further comprising attaching a second neural probe to the neural probe.22. The method of claim 17 , wherein the substrate comprises a silicon substrate and the neural probe is a part of an array of neural probes.2329.-. (canceled) This application claims priority to U.S. Provisional Application Ser. No. 61/007,990, filed Dec. 17, 2007, incorporated herein by reference in its entirety.The ...

Apparatus, system and method for detection and delivery of a medicinal dose

An apparatus is disclosed as part of a system for tracking and confirming delivery of a medicinal dose to a user. The apparatus includes a detector. The detector is secured to and communicatively coupled to the user and is capable of detecting a current flow through the user's body. The current flow is produced when the user makes contact with the apparatus. The apparatus includes at least two contact areas connected to a power source where a circuit and, hence, a current path is completed through the user's body as the user makes contact with the apparatus. The current flow is detected by the detector, which is coupled to the user. Also disclosed is an apparatus for tracking and confirming delivery of a medicinal dose to a user where the apparatus includes an acoustic detector. Upon loading the dose into a chamber an acoustic vibration is generated. The vibration is detected and correlated with a current flow that is produced when the user makes contact with the apparatus. The combined event of vibration detection and current flow detection confirms that the dose is loaded and the user is in contact with the apparatus and ready to receive the dose.

SWALLOWABLE CAPSULE FOR MONITORING A CONDITION

A swallowable capsule () is provided with a drug reservoir () and at least one sensor (). The drug reservoir () is arranged to hold a pharmaceutical composite. A wall () of the drug reservoir () comprises at least one opening for allowing fluid from the surroundings of the capsule () to enter the drug reservoir () and for allowing dissolved drug or liberated particles of the pharmaceutical composite to enter the surroundings of the capsule (). The at least one sensor () is provided for monitoring a condition of the surroundings of the capsule (). 110. A swallowable capsule () , comprising:{'b': 18', '12', '10', '18', '10, 'a drug reservoir () for holding a pharmaceutical composite, with a wall () comprising at least one opening for allowing fluid from the surroundings of the capsule () to enter the drug reservoir () and for allowing dissolved drug or liberated particles of the pharmaceutical composite to enter the surroundings of the capsule (), and'}{'b': 13', '10, 'at least one sensor () for monitoring a condition of the surroundings of the capsule ().'}210181018. A swallowable capsule () as claimed in claim 1 , wherein the drug reservoir () can be opened or detached from the capsule () in order to allow placement of the pharmaceutical composite in the reservoir ().310181212. A swallowable capsule () as claimed in claim 1 , wherein the drug reservoir () comprises a meshed wall () claim 1 , the meshed wall () comprising the at least one opening.41012. A swallowable capsule () as claimed in claim 3 , wherein the meshed wall () is injection molded.51012. A swallowable capsule () as claimed in claim 3 , wherein the meshed wall () comprises meshed metal wires.61013. As swallowable capsule () as claimed in claim 1 , wherein the sensor () is capable of providing time-stamped data.7101513. A swallowable capsule () as claimed in claim 1 , further comprising a transmitter () coupled to the sensor () for transmitting sensor information regarding the monitored condition to an ...

IDENTIFYING AREAS OF THE BRAIN BY EXAMINING THE NEURONAL SIGNALS

The present invention relates to a method of identifying a region of the brain by measuring neuronal firing and/or local field potentials by recording discharges from at least one implanted electrode and analyzing the recording of the discharges within the beta frequency band range to determine an area of beta oscillatory activity. Once the region of the brain is identified, this region may be stimulated to disrupt the beta oscillatory activity thereby treating a movement disorder. 1. A method of identifying a region of the brain comprising the steps of:measuring neuronal firing and/or local field potentials by recording discharges from at least one implanted electrode; andanalyzing the recording of the discharges within the beta frequency band range to determine an area of beta oscillatory activity thereby identifying the region of the brain.2. The method of claim 1 , wherein the electrode is implanted in the cortex claim 1 , subthalamic nucleus claim 1 , basal ganglia claim 1 , or globus pallidus.3. The method of claim 1 , wherein the discharges of neuronal firing and local field potentials are synchronized.4. The method of further comprising the step of stimulating the identified brain region to disrupt the discharges thereby treating a disease.5. The method of claim 4 , wherein the disease is a movement disorder.6. The method of claim 5 , wherein the movement disorder is Parkinson's disease.7. A method of improving at least one symptom in an individual suspected of having a movement disorder claim 5 , comprising the steps of:measuring neuronal firing and/or local field potentials by recording discharges from at least one electrode implanted in the subthalamic nucleus;analyzing the recording of the discharges within the beta frequency band range to determine an area of synchronized beta oscillatory activity; andstimulating the area to disrupt the beta oscillatory activity, thereby improving at least one symptom in the individual.8. The method of claim 7 , wherein ...

Systems And Methods For Using Photoplethysmography In The Administration Of Narcotic Reversal Agents

Provided according to embodiments of the present invention are methods of monitoring and treating respiratory depression that include securing a photoplethysmography (PPG) sensor to a central source site of an individual; administering a central nervous system (CNS) depressant to the individual; processing PPG signals front the PPG sensor with a computer in communication with the PPG sensor; and administering a narcotic reversal agent to the individual if the PPG signals or a physiological parameter derived therefrom are outside a preset value range. Related systems are also described. 1. A method of monitoring and treating respiratory depression comprising:securing a photoplethysmography (PPG) sensor to a central source site of an individual;administering a central nervous system (CNS) depressant to the individual;processing PPG signals from the PPG sensor with a controller in communication with the PPG sensor; andadministering a narcotic reversal agent to the individual if the PPG signals or a physiological parameter derived therefrom are outside a preset value range.2. The method of claim 1 , wherein the narcotic reversal agent is administered to the individual if a respiration rate of the individual is outside the preset value range.3. The method of claim 1 , wherein the narcotic reversal agent is administered to the individual if a respiratory effort of the individual is outside the preset value range.4. The method of claim 1 , wherein the narcotic reversal agent is naloxone.5. The method of claim 1 , further comprising securing to the individual an additional sensor configured to determine at least one parameter selected from respiration rate claim 1 , end-tidal carbon dioxide content claim 1 , blood pressure claim 1 , heart rate and heart rate variability.6. The method of claim 5 , wherein the narcotic reversal agent is administered if (a) the PPG signals or a physiological parameter derived therefrom are outside a first preset value range; and (b) a ...

METHOD AND APPARATUS FOR MONITORING THE RESPIRATION ACTIVITY OF A SUBJECT

The invention relates to a method for monitoring the respiration activity of a subject, comprising the acquisition of a sensor signal of at least one Doppler-Radar sensor representing the respiration activity of a subject, the transformation of the sensor signal into a transformation signal being a series according to Formula (I) where ais a set of predetermined constant coefficients specific for one individual subject, and processing the transformation signal S(t). The transformation signal can be analysed with basic signal processing techniques that are applied in the field of inductive plethysmography. The invention is further related to a corresponding monitoring system. 2. The method according to claim 1 , characterized in that the set of coefficients ais taken from a look-up table.3. The method according to claim 2 , characterized in that the look-up table contains a plurality of different sets of coefficients a.4. The method according to claim 3 , characterized in that the subject is identified claim 3 , and one corresponding set of coefficients ais chosen from the plurality of sets of coefficients aaccording to the result of the identification.6. The method according to claim 1 , characterized in that D(t) is the sum of the sensor signals D(t) claim 1 , i=1 to n from n sensors.7. The method according to claim 1 , characterized in that a plurality of sensor signals D(t) claim 1 , i=1 to n is acquired from a plurality of n sensors claim 1 ,{'sub': 'k', 'and one set of coefficients ais determined for each one of these n sensors.'}1018. System according to claim 9 , characterized by a plurality of Doppler-Radar sensors () disposed at different positions within a measurement range.1120. System according to claim 10 , characterized in that said sensor transformation unit () is provided for transforming a sensor signal D(t) of each sensor i into a transformation signal S(t) and to summarize the resulting transformation signals S(t) to a summarized transformation ...

Controlling an apparatus for fluid transfer to and/or from a subject

A control system ( 23 ) is arranged to control the operation of an apparatus ( 200 ) for extracorporeal blood treatment. The apparatus ( 200 ) comprises an extracorporeal blood circuit ( 20 ) and a connection system (C) for connecting the blood circuit ( 20 ) to the vascular system of a patient. The blood circuit ( 20 ) comprises a blood processing device ( 6 ), and at least one pumping device ( 3 ). The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The blood treatment mode involves operating the blood circuit ( 20 ) to pump blood from the vascular system via the connection system (C) through the blood processing device ( 6 ) and back to the vascular system via the connection system (C). The control system ( 23 ) is operable to obtain measurement data from at least one energy transfer sensor ( 40 ) arranged to sense a transfer of energy between the patient and the connection system (C) or between the patient and the blood circuit ( 20 ). The control system ( 23 ) is configured to, in the pre-treatment mode, process the measurement data for identification of a characteristic change indicating a connection of the blood circuit ( 20 ) to the vascular system of the patient, and, upon such identification, take dedicated action. The action may involve activating at least part of a patient protection system and/or enabling entry into the blood treatment mode. The control system may be included in an apparatus ( 200 ) for blood treatment, such as a dialysis machine.

Neural Monitor-Based Dynamic Haptics

A computer-assisted surgery system may have a robotic arm including a surgical tool and a processor communicatively connected to the robotic arm. The processor may be configured to receive, from a neural monitor, a signal indicative of a distance between the surgical tool and a portion of a patient's anatomy including nervous tissue. The processor may be further configured to generate a command for altering a degree to which the robotic arm resists movement based on the signal received from the neural monitor; and send the command to the robotic arm.

DEVICE FOR APPLYING A PNEUMATIC PRESSURE STIMULUS IN THE NASAL FOSSAE AND EUSTACHIAN TUBE AT THE TIME OF DEGLUTITION

Apparatus for automatically applying a pneumatic overpressure phase, of a value of between 5 and 100 hPa in the Eustachian tube and/or in the nasal fossae of a patient through at least one nostril at the moment of swallowing, includes a gas generator, a gas reservoir, a detection-fluid and control circuit communicating with the gas reservoir and gas generator and leading to a sealed plug in the nostrils forming part of a nosepiece equipped with a control nozzle, a device for measuring at least one characteristic value of a flow of gas during swallowing, a device for automatically comparing the characteristic value with at least one pre-set value, and a device for informing the patient whether the swallowing action is being correctly performed. 1. Device for automatically applying a pneumatic overpressure phase , of a value of between 5 and 100 hPa in a Eustachian tube and/or in a nasal fossae of a patient through at least one nostril at a moment of swallowing , the device comprising a gas generator , a gas reservoir and a detection-fluid and control circuit communicating with the gas reservoir and the gas generator and leading to a sealed plug of a nosepiece equipped with a control nozzle for placement in nostrils; first means for measuring at least one characteristic value of a flow of gas during swallowing , second means for automatically comparing the characteristic value with at least one pre-set value , and third means for informing the patient whether the swallowing action is being correctly performed.2. Device according to claim 1 , wherein the first means comprises means for measuring variation of the flow and/or duration of the variation of the flow on swallowing and the second means comprises means for automatically comparing value of the variation of the flow and/or the duration of the variation of the flow with at least one pre-set value of variation of flow and/or with at least one pre-set duration of variation of flow.3. Device according to claims 1 , ...