Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 10. Отображено 8.
15-11-2016 дата публикации

Therapeutic use of agonists or antagonists of bradykinin receptor 1 or 2, for modulation collateral blood vessel growth

Номер: US0009492495B2
Автор: Philipp Hillmeister, Ivo Buschmann, Ferdinand Lenoble, Nora Gatzke, HILLMEISTER PHILIPP, BUSCHMANN IVO, LENOBLE FERDINAND, GATZKE NORA, Hillmeister Philipp, Buschmann Ivo, Lenoble Ferdinand, Gatzke Nora
Принадлежит: MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN, HILLMEISTER PHILIPP, BUSCHMANN IVO, LENOBLE FERDINAND, GATZKE NORA, Hillmeister Philipp, Buschmann Ivo, Lenoble Ferdinand, Gatzke Nora

The present invention relates to bradykinin receptor modulators and pharmaceutical compositions thereof for use as a medicament for modulating collateral blood vessel growth of collateral arteries and/or other blood vessels of pre-existing arterial networks. The bradykinin receptor modulators of arteriogenesis are applicable in the treatment and/or prevention of disorders associated with defective blood flow or blood vessel malformation. A preferred aspect of the invention relates to bradykinin receptor agonists for use as a medicament for the prevention of cardiovascular ischemic disease in a patient at risk thereof. Further, the invention relates to a bradykinin receptor agonist for use in a method for treating a cardiovascular ischemic disease in a patient in need thereof, wherein said cardiovascular ischemic disease is a peripheral limb disease.

Подробнее
Номер записи: 1
17-09-2019 дата публикации

Method and device for monitoring and improving arteriogenesis

Номер: US0010413195B2
Автор: Ivo Buschmann, Axel Pries, Ferdinand Lenoble, BUSCHMANN IVO, PRIES AXEL, LENOBLE FERDINAND, Buschmann, Ivo, Pries, Axel, Lenoble, Ferdinand
Принадлежит: Ivo Buschmann, BUSCHMANN IVO, PRIES AXEL, LENOBLE FERDINAND, Buschmann Ivo, Pries Axel, Lenoble Ferdinand

A method for determining an arteriovascular condition of a subject having an arterial blood flow is shown. The method involves determining a temporal progression of an instantaneous blood flow condition of the arterial blood flow as well as deriving a slew rate of the temporal progression during an increase of the temporal progression. In addition, an arteriovascular condition indicator device is shown, which comprises: an input for receiving an input signal representing an instantaneous arterial blood flow condition of a subject and a slew rate monitor connected to the input. A corresponding control device for providing an activation signal is also shown. The control device comprises a maximum detector connected to the slew rate monitor. A method for stimulation of arteriogenesis is also shown, wherein a temporal progression of an instantaneous blood flow condition is monitored, a slew rate of the temporal progression is derived, and the maximum of the slew rate is determined. An external pressure is applied repeatedly to the arteriovascular section in synchronization with the occurrence of the determined maximum.

Подробнее
Номер записи: 2
30-05-2013 дата публикации

THERAPEUTIC USE OF AGONISTS OR ANTAGONISTS OF BRADYKININ RECEPTOR 1 OR 2, FOR MODULATION COLLATERAL BLOOD VESSEL GROWTH

Номер: US20130136717A1
Автор: Philipp Hillmeister, Ivo Buschmann, Ferdinand Lenoble, Nora Gatzke
Принадлежит: MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN

The present invention relates to bradykinin receptor modulators and pharmaceutical compositions thereof for use as a medicament for modulating collateral blood vessel growth of collateral arteries and/or other blood vessels of pre-existing arterial networks. The bradykinin receptor modulators of arteriogenesis are applicable in the treatment and/or prevention of disorders associated with defective blood flow or blood vessel malformation. A preferred aspect of the invention relates to bradykinin receptor agonists for use as a medicament for the prevention of cardiovascular ischemic disease in a patient at risk thereof. Further, the invention relates to a bradykinin receptor agonist for use in a method for treating a cardiovascular ischemic disease in a patient in need thereof, wherein said cardiovascular ischemic disease is a peripheral limb disease. 1. Bradykinin receptor modulator for use as a medicament for modulating collateral blood vessel growth of collateral arteries and/or other blood vessels of pre-existing arterial networks.2. A method for modulating collateral blood vessel growth of collateral arteries and/or other blood vessels of pre-existing arterial networks comprisingadministering to a patient in need of treatment and/or prevention of a disorders associated with defective blood flow a bradykinin receptor modulator in an modulating collateral blood vessel growth of collateral arteries and/or other blood vessels of pre-existing arterial networks effective amount.3. The method of claim 2 , wherein said bradykinin receptor modulator is a bradykinin receptor 1 (B1R) and/or a bradykinin receptor 2 (B2R) modulator.4. The method of claim 2 , wherein the modulator is a bradykinin receptor agonist.5. The method of wherein the bradykinin receptor agonist is administered prophylactically and wherein said patient is at risk of cardiovascular ischemic disease.6. The method of claim 5 , wherein said cardiovascular ischemic disease is(a) cerebral ischemia, in ...

Подробнее
Номер записи: 3
08-03-2012 дата публикации

Method and device for monitoring and improving arteriogenesis

Номер: US20120059245A1
Автор: Axel Pries, Ferdinand Lenoble, Ivo Buschmann
Принадлежит: Charite Universitaetsmedizin Berlin

A method for determining an arteriovascular condition of a subject having an arterial blood flow is shown. The method involves determining a temporal progression of an instantaneous blood flow condition of the arterial blood flow as well as deriving a slew rate of the temporal progression during an increase of the temporal progression. In addition, an arteriovascular condition indicator device is shown, which comprises: an input for receiving an input signal representing an instantaneous arterial blood flow condition of a subject and a slew rate monitor connected to the input. A corresponding control device for providing an activation signal is also shown. The control device comprises a maximum detector connected to the slew rate monitor. A method for stimulation of arteriogenesis is also shown, wherein a temporal progression of an instantaneous blood flow condition is monitored, a slew rate of the temporal progression is derived, and the maximum of the slew rate is determined. An external pressure is applied repeatedly to the arteriovascular section in synchronization with the occurrence of the determined maximum.

Подробнее
Номер записи: 4
02-06-2016 дата публикации

Method and device for monitoring and improving arteriogenesis

Номер: US20160150979A1
Автор: Axel Pries, Ferdinand Lenoble, Ivo Buschmann
Принадлежит: Individual

A method for determining an arteriovascular condition of a subject having an arterial blood flow is shown. The method involves determining a temporal progression of an instantaneous blood flow condition of the arterial blood flow as well as deriving a slew rate of the temporal progression during an increase of the temporal progression. In addition, an arteriovascular condition indicator device is shown, which comprises: an input for receiving an input signal representing an instantaneous arterial blood flow condition of a subject and a slew rate monitor connected to the input. A corresponding control device for providing an activation signal is also shown. The control device comprises a maximum detector connected to the slew rate monitor. A method for stimulation of arteriogenesis is also shown, wherein a temporal progression of an instantaneous blood flow condition is monitored, a slew rate of the temporal progression is derived, and the maximum of the slew rate is determined. An external pressure is applied repeatedly to the arteriovascular section in synchronization with the occurrence of the determined maximum.

Подробнее
Номер записи: 5
15-08-2019 дата публикации

Method and device for monitoring and improving arteriogenesis

Номер: US20190246911A1
Автор: Axel Pries, Ferdinand Lenoble, Ivo Buschmann
Принадлежит: Individual

A method for determining an arteriovascular condition of a subject having an arterial blood flow is shown. The method involves determining a temporal progression of an instantaneous blood flow condition of the arterial blood flow as well as deriving a slew rate of the temporal progression during an increase of the temporal progression. In addition, an arteriovascular condition indicator device is shown, which comprises: an input for receiving an input signal representing an instantaneous arterial blood flow condition of a subject and a slew rate monitor connected to the input. A corresponding control device for providing an activation signal is also shown. The control device comprises a maximum detector connected to the slew rate monitor. A method for stimulation of arteriogenesis is also shown, wherein a temporal progression of an instantaneous blood flow condition is monitored, a slew rate of the temporal progression is derived, and the maximum of the slew rate is determined. An external pressure is applied repeatedly to the arteriovascular section in synchronization with the occurrence of the determined maximum.

Подробнее
Номер записи: 6
17-11-2011 дата публикации

Therapeutic use of agonists or antagonists of bradykinin receptor 1 or 2, for modulation collateral blood vessel growth

Номер: WO2011141188A1
Автор: Ferdinand Lenoble, Ivo Buschmann, Nora Gatzke, Philipp Hillmeister
Принадлежит: MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN

The present invention relates to bradykinin receptor modulators and pharmaceutical compositions thereof for use as a medicament for modulating collateral blood vessel growth of collateral arteries and/or other blood vessels of pre-existing arterial networks. The bradykinin receptor modulators of arteriogenesis are applicable in the treatment and/or prevention of disorders associated with defective blood flow or blood vessel malformation. A preferred aspect of the invention relates to bradykinin receptor agonists for use as a medicament for the prevention of cardiovascular ischemic disease in a patient at risk thereof. Further, the invention relates to a bradykinin receptor agonist for use in a method for treating a cardiovascular ischemic disease in a patient in need thereof, wherein said cardiovascular ischemic disease is a peripheral limb disease.

Подробнее
Номер записи: 7
26-10-2011 дата публикации

Method and device for monitoring and improving arteriogenesis

Номер: EP2378957A1
Автор: Axel Pries, Ferdinand Lenoble, Ivo Buschmann
Принадлежит: Charite Universitaetsmedizin Berlin, Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft

A method for determining an arteriovascular condition of a subject having an arterial blood flow is shown. The method involves determining a temporal progression of an instantaneous blood flow condition of the arterial blood flow as well as deriving a slew rate of the temporal progression during an increase of the temporal progression. In addition, an arteriovascular condition indicator device is shown, which comprises: an input for receiving an input signal representing an instantaneous arterial blood flow condition of a subject and a slew rate monitor connected to the input. A corresponding control device for providing an activation signal is also shown. The control device comprises a maximum detector connected to the slew rate monitor. A method for stimulation of arteriogenesis is also shown, wherin a temporal progression of an instantaneous blood flow condition is monitored, a slew rate of the temporal progression is derived, and the maximum of the slew rate is determined. An external pressure is applied repeatedly to the arteriovasculat section in synchronization with the occurrence of the determined maximum.

Подробнее
Номер записи: 8