Sensor for detecting electrical biopotential, particularly for use in medical apparatus, prosthesis liner, sleeve or belt, has substrate with multiple needles, where shell extends partially over main surface of substrate

The sensor (1) has a substrate (3) with multiple needles (5) which is sticked out from a main surface (7) to the substrate. The needles have certain length for penetrating an outer layer of the skin of a human or animal body. The needle is placed on the skin around an adjacent skin layer for providing an electrical contact. The substrate is partially covered by a shell (15) which extends partially over the main surface of the substrate. The shell is made of flexible plastic, particularly silicone. The substrate is a semiconductor substrate, particularly a silicon substrate.

Optical sensor for in situ measurement of analytes

Sensor

Transdermal bioreactor

SELECTIVE EXPOSITION OF MINIATURE PROBES WITH INTEGRATED SENSOR ARRAYS FOR CONTINUOUS IN-VIVO DIAGNOSIS

MANUFACTURING PROCESS FOR A MEDICAL ELECTRODE

PROCEDURE AND DEVICE FOR BRINGING IN OF ADDITIVES

MEDICINE PRODUCT FOR THE ANALYTENÜBERWACHUNG AND DRUG DELIVERY

CATHETER SUITOR OF IMPLANTIERBARER NEEDLE BIO SENSOR

VERFAHREN UND VORRICHTUNG ZUR EINBRINGUNG VON ZUSATZSTOFFEN

The invention relates to a method and a device for introducing and/or adding non-dry-powder additive materials and/or coating materials with a liquid, solid, semi-solid, or paste-like consistency or in suspended or emulsified form, for example, peroxides, fats, waxes, IV improvers, polymers, or similar materials, to an existing lumpy or particulate material which is moved and mixed, and optionally warmed and reduced to small pieces in a receptacle and/or compressor (1), said material being in particular polymer particles and/or flakes, wood fibers, paper cuttings, or similar materials. According to the invention, the additive material is introduced below the level of the material and/or material particles already in the receptacle (1).

A system for determining fluid level in a biological subject

A system for performing fluid level measurements on a biological subject, the system including at least one substrate including a plurality of microstructures configured to breach a stratum corneum of the subject, at least some microstructures including an electrode, a signal generator operatively connected to at least one microstructure to apply an electrical stimulatory signal to the at least one microstructure and at least one sensor operatively connected to at least one microstructure, the at least one sensor being configured to measure electrical response signals from at least one microstructure. The system also includes one or more electronic processing devices that determine measured response signals, the response signals being at least partially indicative of a bioimpedance and perform an analysis at least in part using the measured response signals to determine at least one indicator at least partially indicative of fluid levels in the subject.

Analyte detection system

A system for detecting analytes in a biological subject, the system including at least one substrate including a plurality of microstructures configured to breach a stratum corneum of the subject, and wherein a presence, absence, level or concentration of analytes is able to be detected by contact of the microneedles with the analytes causing a change in appearance in at least one of the microstructures, the substrate or the stratum corneum of the subject.

METHODS AND DEVICES FOR DETECTION AND ACQUISITION OF BIOMARKERS

The present invention provides devices and methods for detecting and capturing molecular biomarkers from a subject in situ. Specifically, the devices contain an array of microneedles to which are attached probes specific for one or more biomarkers of interest. The devices can be used directly on a subject (e.g., via skin piercing) in detecting the biomarkers in the body of the subject (e.g., tissues, blood stream).

Medical device for analyte monitoring and drug delivery

MEDICAL DEVICE FOR ANALYTE MONITORING AND DELIVERY 5 Disicosed is an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical 10 parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning 15 device, biometric recognition device and the therapeutic agent releasing device ...

Methods and devices for detection and acquisition of biomarkers

The present invention provides devices and methods for detecting and capturing molecular biomarkers from a subject in situ. Specifically, the devices contain an array of microneedles to which are attached probes specific for one or more biomarkers of interest. The devices can be used directly on a subject (e.g., via skin piercing) in detecting the biomarkers in the body of the subject (e.g., tissues, blood stream).

DELIVERING AND/OR RECEIVING FLUIDS

The present application generally relates to receiving bodily fluid through a device opening. The device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator.

Percutaneous biological fluid constituent sampling and measurement devices and methods

AN INTEGRATED CIRCUIT MODULE WITH LEAD FRAME MICRO-NEEDLES

An integrated circuit (IC) module with a lead frame micro-needle for a medical device, and methods of forming the IC module are described. The methods include forming a lead frame blank including a micro-needle integrally formed therein. The micro-needle may be bent beyond an initial lower side of the lead frame blank. The initial lower side may be joined with a protection layer such that the bent micro-needle is embedded in the protection layer, which may be removably attached to the initial lower side and the bent micro-needle. An IC component may be affixed to an upper side of the lead frame blank. The IC component and an upper surface of a core of the lead frame blank may be encapsulated with a molding compound forming a packaging of the IC module. Removal of the protection layer may expose the bent micro-needle projecting away from the packaging.

PROCESS AND DEVICE FOR INTRODUCING ADDITIVES

The invention relates to a method and a device for introducing and/or add ing non-dry-powder additive materials and/or coating materials with a liquid , solid, semi-solid, or paste-like consistency or in suspended or emulsified form, for example, peroxides, fats, waxes, IV improvers, polymers, or simil ar materials, to an existing lumpy or particulate material which is moved an d mixed, and optionally warmed and reduced to small pieces in a receptacle a nd/or compressor (1), said material being in particular polymer particles an d/or flakes, wood fibers, paper cuttings, or similar materials. According to the invention, the additive material is introduced below the level of the m aterial and/or material particles already in the receptacle (1).

SYSTEM FOR MONITORING BODY BY ELECTROPHORESIS

MINIMALLY INVASIVE DETECTING DEVICE

THE METHOD FOR MANUFACTURING HALLOW MICRONEEDLE STRUCTURES

SYSTEM AND METHOD FOR NON-INVASIVE DIAGNOSIS OF MELANOMA

The application describes a grating storage unit (50) for light multiplexing comprising a grating imprinted or fabricated on a disc (52) or a tape and a reading head (56). The grating storage unit is characterized in that different areas of the grating have different values of the one or more of the following grating parameters: density of the grooves; groove depth, geometrical shape of the grooves, and refractive index. The grating storage unit can be optically- coupled (74) to an Attenuated Reflection (AR) probe. In embodiments of the application the AR probe is a multi-channel attenuated reflection (AR) sensor head adapted for nevi probing. The sensor head can comprise AR pin probes (82) adapted to be used as Attenuated Total Reflection (ATR) probes or Scanning Near field Optical Microscope (SNOM) pin probes. In the latter case the AR probe is used as a MIR sub cellular sensor. The grating storage unit and AR probe can be used in a system for non-mvasive assessment of the condition of ...

RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS

The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain ...

SYSTEMS AND METHODS FOR APPLICATION TO SKIN AND CONTROL OF ACTUATION, DELIVERY AND/OR PERCEPTION THEREOF

The present invention generally relates, in certain aspects, to systems and methods for application to the skin, and control of actuation, delivery, and/or perception thereof. For example, certain aspects of the invention are generally directed to devices for delivering to and/or withdrawing fluid or from subjects, e.g., to or from the skin and/or beneath the skin. In one aspect, the delivery and/or withdrawal of fluid is at least partially obscured. For example, the obscuration may be by time, and/or by sensory obscuration (e.g., by providing tactile, olfactory, auditory, and/or visual sensations). Certain aspects of the invention are generally directed to devices able to automatically deliver to and/or withdraw fluid from the skin and/or beneath the skin after activation, e.g., where the fluid is delivered and/or withdrawn without the need for any additional intervention. The devices may be activated by any suitable technique. In other aspects, a device may be contained in a package, ...

BIOLOGICAL INTERFACE SYSTEM

A system and method for an improved biological interface system that processes multicellular signals of a patient and controls one or more devices is disclosed. The system includes a sensor that detects the multicellular signals and a processing unit for producing the control signal based on the multicellular signals. The system may include improved communication, self-diagnostics, and surgical insertion tools.

NEURON SIGNAL ANALYSIS SYSTEM AND METHOD

Electrical signals are collected by a microelectrode (120) positioned in a tissue. The signals are communicated to a signal data analyzer (300) that includes logic (130) for producing a statistical distribution of the electrical signals. The statistical distribution facilitates identification logic (315) distinguishing noise signals from neuronal discharge activity signals. The statistical distribution is analyzed to determine and report the nature, if any, of neuronal discharge activity in the location of the microelectrode (120). A microelectrode positioner (155) programmatically repositions the microelectrode (120) based on the nature of the neuronal discharge activity.

Monitoring platform for wound and ulcer monitoring and detection

Systems and techniques for monitoring hydration. In one implementation, a method includes measuring an electrical impedance of a region of a subject to generate an impedance measurement result, and wirelessly transmitting the data to a remote apparatus. The probe with which impedance is measured may in the form of a patch adhesively secured to the subject.

Method and apparatus for transdermal stimulation over the palmar and plantar surfaces

The disclosure describes devices and methods for providing transdermal electrical stimulation therapy to a subject including positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject and delivering electrical stimulation via a pulse generator transdermally through the glabrous skin surface and to a target nerve or tissue within the hand to stimulate the target nerve or tissue within the hand so that pain felt by the subject is mitigated. The pulses generated during the electrical stimulation therapy may include pulses of two different magnitudes.

MICRO-MOLDED ELECTRODES, ARRAYS, AND METHODS OF MAKING THE SAME

A method of manufacturing a micro-molded electrode (160) having multiple individually addressable sensors (140) along a shaft (180) can include forming a recess in a mold substrate, depositing a structural material therein, depositing a conductive material at specific locations, providing a coating (190), and removing the mold substrate. A micro-molded electrode (160) having a base (170) tapering to at least one shaft (180) can include an electrode substrate, multiple individually addressable sensors (140), and a coating (190).

Method for fabricating microneedle-based diagnostic skin patch coated with aptamer and patch

The present invention relates to a method for fabricating a microneedle-based diagnostic skin patch coated with an aptamer, comprising treating a microneedle surface with base to modify the surface with carboxyl group and binding the carboxyl group of the surface with an aptamer with an amine group and an aptamer-coated, microneedle-based diagnostic skin patch thereby. A patch of the present invention has the advantage of attaching a great number of aptamers, which are much smaller in size than antibodies, onto a relatively great number of microneedle tip surfaces, Allowing the attachment of aptamers for various kinds of biomarkers all together thereto, the patch can also simultaneously detect various kinds of materials (multiplexing). Therefore, a microneedle tip-based skin patch can also be used as a protein chip using aptamer.

Systems and methods of sample processing and fluid control in a fluidic system

This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

MICRONEEDLES MADE FROM POLYCARBONATE-POLYCARBONATE/POLYSILOXANE COPOLYMER COMPOSITIONS

A microneedle includes a shaft having a proximal end and a distal end and a capillary space within the shaft, the capillary space (i) connecting the proximal and distal ends or (ii) extending from the distal end of the shaft and connecting with one or more external openings positioned between the proximal end and distal end or (iii) performing the functions of both (i) and (ii). The microneedle includes a polymer mixture which includes (a) optionally polycarbonate, (b) a polycarbonate-polysiloxane copolymer and (c) a mold release agent.

INTRAFASCICULAR ELECTRODE IMPLANT

An implantable device for intrafascicular stimulation and/or sensing of a peripheral nerve, including a blocking element adapted for wrapping a nerve, comprising an access point and an exit point, and an electrode adapted to traverse the blocking element via the access point and the exit point having a distal end, a proximal end and an elongated body in between, the electrode being electrically isolated from the surrounding environment except that for an active site. In another aspect, the invention features a system comprising the implantable device of the invention operably coupled with an external device such an electrostimulator and/or a sensing device for sensing and recording electrical nerve signals.

PHYSIOLOGICAL SIGNAL DETECTING DEVICE AND SYSTEM

A device configured to detect, measure, and/or monitor physiological signals of a mammal. The device and system can detect a pulse and/or skin bioimpedance of a mammal and determine one or more physiological parameters based on the detected pulse and/or dermal bioimpedance. The device and system converts one or more physiological signals detected by the one or more sensors into one or more physiological parameters and stores the physiological parameters as electronic data, the electronic data being related to a physiological condition of the mammal.

IRRITATION-LIMITING SENSOR FOR BODY MONITORING DEVICE

The invention relates to a sensor for a body monitoring device comprising: an inner face (31) designed to come into contact with an individual's skin; at least one micro-needle (32) arranged on said inner face (32); at least one pad (34) arranged on the inner face of the substrate close to a microneedle and configured to absorb/adsorb moisture when the sensor (3) is on the skin.

RELATIVELY SMALL DEVICES APPLIED TO THE SKIN, MODULAR SYSTEMS, AND METHODS OF USE THEREOF

Einheitlicher Multielektrodenbiopotentialsensor und Herstellungsverfahren desselben.

HERSTELLUNGSVERFAHREN FÜR EINE MEDIZINISCHE ELEKTRODE

Multi-probe microstructed arrays

Device and method for diabetes and other disorders

MINIMAL INVASIVE INDICATOR

NAVIGATED MIKROSONDE

NEURON SIGNAL ANALYSIS SYSTEM

UNIFORM MULTI-ELECTRODE BIO POTENTIAL SENSOR AND MANUFACTURING PROCESS OF THE SAME.

DIAGNOSTIC TEST ELEMENT AND PROCEDURE FOR ITS PRODUCTION

MINIATURE ELECTRODE FOR DETECTING INTERSTITIAL TISSUE PH

NEURON SIGNAL ANALYSIS SYSTEM AND METHOD

Optical sensor for in situ measurement of analytes

OPTICAL SENSOR FOR IN SITU MEASUREMENT OF ANALYTES

An implantable sensor for use in the detection or quantitative measurement of an analyte in subcutaneous fluid, the sensor being biodegradable or hydrolysable in vivo. The sensor incorporates an assay for the analyte, the readout of which is a detectable or measurement optical signal which can, when the sensor is in operation in a subcutaneous location, be interrogated transcutaneously by external optical means.

FLUID INFUSION SYSTEMS

A fluid infusion system such as a portable fluid infusion device includes a housing to accommodate a fluid reservoir. The housing has a largest dimension and a smallest dimension. The fluid infusion device includes a drive system to be serially coupled to the removable fluid reservoir such that a combined dimension of the drive system and the fluid reservoir is less than or equal to the largest dimension. The fluid infusion device includes a planar battery configured to supply power to the drive system. The planar battery has a plurality of faces with one or more faces having a largest area, and the planar battery is situated such that the one or more faces are parallel to the largest dimension and the smallest dimension.

NEURON SIGNAL ANALYSIS SYSTEM AND METHOD

Electrical signals are collected by a microelectrode (120) positioned in a tissue. The signals are communicated to a signal data analyzer (300) that includes logic (130) for producing a statistical distribution of the electrical signals. The statistical distribution facilitates identification logic (315) distinguishing noise signals from neuronal discharge activity signals. The statistical distribution is analyzed to determine and report the nature, if any, of neuronal discharge activity in the location of the microelectrode (120). A microelectrode positioner (155) programmatically repositions the microelectrode (120) based on the nature of the neuronal discharge activity.

MICROFABRICATED NEUROSTIMULATION DEVICE AND METHODS OF MAKING AND USING THE SAME

... ²Described herein are microelectrode array devices, and methods of fabrication ²and use ²of the same, to provide highly localised and efficient electrical stimulation ²of a ²neurological target. The device includes multiple microelectrode elements ²arranged ²along an supportive backing layer. The microelectrode elements are dimensioned ²and ²shaped so as to target individual neurons, groups of neurons, and neural ²tissue as may ²be located in an animal nervous system, such as along a region of a cortex of ²a human ²brain. Beneficially, the neurological probe can be used to facilitate location ²of the ²neurological target and remain implanted for long-term monitoring and/or ²simulation.² ...

IMPLANTABLE SENSOR ELEMENT

The invention relates to a sensor element (110) for detecting at least one analyte in a body fluid or in a body tissue (130), particularly for determining at least one metabolite concentration in a body fluid. The sensor element (110) comprises an implantable, one-piece shaped body (112), which comprises a sensor end (114) and a coupling end (116). The shaped body (112) comprises, in the area of the sensor end (114), at least one sensor area (118), which comprises at least one sensor material (122). The sensor material (122) changes at least one optically measurable property in the presence of the analyte. The shaped body (112) also has at least one optically transparent coupling part (120), which is designed to transmit electromagnetic radiation in at least one spectral range between the sensor area (118) and the coupling end (116). In the sensor area (118), the shaped body (112) has at least one optically transparent matrix material (124), and the analyte can at least partially diffuse ...

SENSOR FOR MEASURING THE ACTIVITY OF .BETA.-PANCREATIC CELLS OR OF ISLETS OF LANGERHANS, MANUFACTURE AND USE OF SUCH A SENSOR

L'invention concerne un capteur (2) comprenant : un ensemble de microélectrodes (21 ); et des cellules ß-pancréatiques (23) ou des îlots (230) de Langerhans en culture sur l'ensemble de microélectrodes (21 ); caractérisé en ce que l'ensemble de microélectrodes (21 ) est adapté pour mesurer dynamiquement, en temps réel et en continu, des signaux électriques (V) produits par les cellules (23) ß-pancréatiques ou les îlots (230) de Langerhans lors de leur activation physiologique. L'invention concerne également le domaine des dispositifs pouvant être implantables dans le corps d'un patient, et comprenant un distributeur à insuline pour distribuer une quantité d'insuline. L'invention concerne également un procédé pour fabriquer un tel capteur et un tel dispositif et une utilisation d'un tel capteur.

MINIMALLY INVASIVE DETECTING DEVICE

An agent detecting device comprising a plate (6) having a plurality of microprotrusions (4) for piercing the skin of a patient. Each of the microprotrusions (4) having an electrode (14, 16 and 18) thereon for detecting the presence of an agent in the patient's interstitial fluid.

Method for manufacturing Hollow Microneedle with Controlled External Appearance Characteristics

HOLLOW MICRO NEEDLE WHOSE EXTERNAL SHAPE IS CHANGEABLE CAPABLE OF CONTROLLING THE THICKNESS OF A BOARD, THE DIAMETER OF A LIFTING FRAME, LIFTING SPEED, LIFTING TIME, A TEMPERATURE, AND AN INCLINED ANGLE FOR CUTTING

PURPOSE: A hollow micro needle whose external shape is changeable is provided to control an effective length, the inner diameter and outer diameter of an upper part, the diameter and the hardness of a lower part, a sharpness degree, an inclined angle, an aspect ratio, and a bending degree. CONSTITUTION: A method for manufacturing a hollow micro needle whose external shape is changeable comprises the following steps. A viscid solution is spread on a board. The viscid solution contacts a frame. The board, the frame, or the board and the frame are lifted to separate the frame from the board which contacts the frame so that a solid micro structure is manufactured. Metal is deposited on the solid micro structure. Metal is plated on the surface of the micro structure while protecting the upper part of the solid micro structure on which metal is deposited. A hollow micro structure is obtained by eliminating the solid micro structure. COPYRIGHT KIPO 2012 ...

Process and device for introducing additives

The invention relates to a process and a device for introducing or adding non-dry powdery additives or coating substances having a liquid, solid, semi-solid or pasty consistency or in a suspended or emulsified form, such as e.g. peroxides, fats, waxes, IV improvers, polymers or the like, to a material which is moved in a receptacle or cutting compactor (1), mixed and optionally heated and crushed, present in a fragmented or particle form, in particular polymer particles or flakes, wood fibres, paper shreds or the like. According to the invention, it is provided that the additives be added below the level or the material or material particles found in the container (1) (Fig.1).

FIBER ARRAY FOR OPTICAL IMAGING AND THERAPEUTICS

The present invention relates to the field of optical imaging and therapeutics. More particularly, embodiments of the present invention provide minimally-invasive Fiberoptic Microneedle Devices (FMDs) for light-based therapeutics, which physically penetrate tissue and deliver light directly into the target area below the skin surface (FIG. 1). A preferred embodiment of the invention is a fiberoptic microneedle device comprising: (a) one or more silica-based needles capable of guiding light and comprising a length of about 0.5-6 mm, a base having an outer diameter in the range of about 100-150 micron, and a tip having an outer diameter in the range of about 5-20 micron; (b) a support member to which the needles are secured; (c) a ferrule comprising one or more holes for each of the needles, wherein the ferrule is operably configured to provide mechanical support to each needle at all or some portion of the length of the needle. Embodiments of the invention enable depth-selective and deep ...

INSULATION OF MICRO STRUCTURES

The application discloses a method of providing a metal coating on a substrate (10), and electrically insulating sections/parts of the metal coated substrate from each other. A substrate is provided with an insulating material in the substrate, said insulating first material extending through the thickness of the substrate and protruding above one surface of the substrate. It forms an enclosed section/portion (14) of the substrate. A protective structure (15) is provided on the insulating material such that it covers the entire circumference thereof. The insulating material is selectively etched to create an under-etch (18) under said protective structure. Finally conductive material (19) is deposited to provide a metal coating over the substrate, whereby the underetch will provide a disruption in the deposited metal coating, thereby electrically insulating the enclosed section from the surrounding substrate.

SUBSTRATE FOR A TEMPERATURE-COMPENSATED SURFACE ACOUSTIC WAVE DEVICE OR VOLUME ACOUSTIC WAVE DEVICE

A substrate for a surface acoustic wave device or bulk acoustic wave device, comprising a support substrate and an piezoelectric layer on the support substrate, wherein the support substrate comprises a semiconductor layer on a stiffening substrate having a coefficient of thermal expansion that is closer to the coefficient of thermal expansion of the material of the piezoelectric layer than that of silicon, the semiconductor layer being arranged between the piezoelectric layer and the stiffening substrate.

ELECTRICALLY FUNCTIONAL POLYMER MICRONEEDLE ARRAY

A sensor device, such as a biosensor, may comprise a polymer substrate, which is structured so as to form sets of microneedles and respective vias. The microneedles extend, each, from a base surface of the substrate. Each of the vias extends through a thickness of the substrate, thereby forming a corresponding set of apertures on the base surface. Each of the apertures is adjacent to a respective one of the microneedles. The device further may comprise two or more electrodes, these including a sensing electrode and a reference electrode. Each electrode may comprise an electrically conductive material layer that coats a region of the substrate, so as to coat at least some of the microneedles and neighboring portions of said base surface. Related devices, apparatuses, and methods of fabrication and use of such devices may be provided.

PHYSIOLOGICAL SIGNAL MONITORING DEVICE

A physiological signal monitoring device includes a base, a biosensor mounted to the base, a transmitter, and a sealing unit. The base is adapted to be mounted to a skin surface of a host. The biosensor includes a mounting seat and a sensing member that is mounted to the mounting seat. The sensing member is adapted to be partially inserted underneath the skin surface of the host for measuring an analyte of the host and to send a corresponding physiological signal. The transmitter is for receiving and transmitting the physiological signal, and has a bottom portion. The transmitter covers the base while the bottom portion faces the base. The sensing member is coupled to the transmitter. The sealing unit is used to seal paths through which a liquid possibly penetrates into an interior of the physiological signal monitoring device so as to avoid damage of the device.

PEPTIDE NUCLEIC ACID FUNCTIONALIZED HYDROGEL MICRONEEDLES FOR SAMPLING AND DETECTION OF INTERSTITIAL FLUID NUCLEIC ACIDS

The present disclosure relates to a device, comprising a base and a plurality of microneedles attached to the base, wherein each microneedle has an outer surface; the outer surface of at least one microneedle being coated with a composition comprising at least one polymer and least one Peptide Nucleic Acid (PNA). The present disclosure additionally relates to a method of detecting an analyte in interstitial fluid (ISF), comprising contacting the device to a subject, for example, to human skin.

ELECTRICALLY FUNCTIONAL POLYMER MICRONEEDLE ARRAY

A sensor device, such as a biosensor, may comprise a polymer substrate, which is structured so as to form sets of microneedles and respective vias. The microneedles extend, each, from a base surface of the substrate. Each of the vias extends through a thickness of the substrate, thereby forming a corresponding set of apertures on the base surface. Each of the apertures is adjacent to a respective one of the microneedles. The device further may comprise two or more electrodes, these including a sensing electrode and a reference electrode. Each electrode may comprise an electrically conductive material layer that coats a region of the substrate, so as to coat at least some of the microneedles and neighboring portions of said base surface. Related devices, apparatuses, and methods of fabrication and use of such devices may be provided.

METHOD AND APPARATUS FOR MEASUREMENT AND VISUAL FEEDBACK OF PHYSIOLOGIC SIGNALS THROUGH HEADWORN DEVICE

An apparatus for obtaining EEG signals utilizes adjustable arms and EEG sensors mounted on an adjustable frame adapted to fit the head of an individual.

Micro-fluidic test apparatus and method

An apparatus, system, and method for determining the osmolarity of a fluid. The apparatus includes at least one micro-fluidic circuit and at least one electrical circuit disposed in communication with the micro-fluidic circuit for determining a property of a fluid contained within the at least one micro-fluidic circuit.

SYSTEM FOR MONITORING BODY CHEMISTRY

Wearable sensor patches, applicator systems for applying wearable sensor patches, and associated systems, devices, and methods are disclosed herein. In one embodiment, an applicator system includes a first applicator portion, a second applicator portion, a spring, and a trigger mechanism. The first applicator portion releasably retains a wearable sensor patch configured to detect a parameter of an analyte in fluid of a user. When the applicator system is in a loaded mode, the spring and the first applicator portion are positioned within the second applicator portion such that the spring is positioned between the first applicator portion and the second applicator portion. The trigger mechanism is configured to initiate a transition of the applicator system from the loaded mode to a released mode such that the spring accelerates the first applicator portion distally away from the second applicator portion to apply the wearable sensor patch to the user.

ELECTRODE ARRAY AND METHOD OF MANUFACTURE

The electrode array is a device for making multiple electrical contacts with cellular tissue or organs. The electrode array includes a base (1), a two dimensional array of conducting protuberances (2) arising from the base and serving as electrodes, and conductors (3) embedded onto the base and connected to such protuberances for transmitting electrical signals to and/or from the protuberances. The protuberances may also include an insulating layer (15) which covers either the entire protuberance or which leaves the tips exposed for making focused electrical contact. Electrode arrays may be used singly or in combination with a second electrode array so as to form a sandwich around a target tissue. The sandwich electrode array (16, 17) may employ indexing cones for aligning the opposing electrode arrays and for limiting their vertical proximity. The conductors of the electrode array may be electronically connected or coupled to processing circuitry which amplifies and analyzes the signal ...

СПОСОБ И УСТРОЙСТВО ДЛЯ ВВЕДЕНИЯ ПРИСАДОК

... 1. Способ для введения или подачи не сухих гранулированных, в частности не сухих порошкообразных присадок или материалов покрытия с жидкой, твердой, полутвердой или пастообразной консистенцией, при необходимости, в суспендированной или эмульгированной форме, в частности, с повышенной вязкостью, в виде пероксидов, жиров, воска, средств, улучшающих инверсионную способность, полимеров или т.п., подобное, к перемещаемому в приемном резервуаре (1) или в режущем компрессоре, смешанному при необходимости, нагретому и раздробленному материалу в виде кусочков или гранул, в частности полимерных частиц или полимерных кусочков, древесных волокон, бумажных обрезков т.п., причем присадки подают ниже уровня находящегося в резервуаре (1) материала или частиц материала, отличающийся тем, что присадки, в частности присадки с очень высокой вязкостью подают в ту зону или на той высоте резервуара (1), на которой, в частности, вращающиеся в резервуаре (1) частицы материала оказывают максимальное давление на ...

СПОСОБ И СИСТЕМА ДЛЯ ПОДКОЖНОГО СЕНСОРНОГО ОПРЕДЕЛЕНИЯ

BLOOD MONITORS AND PROCEDURES FOR IT

SET WITH A CARTRIDGE FOR EXTRACTING ANALYTEN

VERFAHREN UND VORRICHTUNG ZUR EINBRINGUNG VON ZUSATZSTOFFEN

The invention relates to a method and a device for introducing and/or adding non-dry-powder additive materials and/or coating materials with a liquid, solid, semi-solid, or paste-like consistency or in suspended or emulsified form, for example, peroxides, fats, waxes, IV improvers, polymers, or similar materials, to an existing lumpy or particulate material which is moved and mixed, and optionally warmed and reduced to small pieces in a receptacle and/or compressor (1), said material being in particular polymer particles and/or flakes, wood fibers, paper cuttings, or similar materials. According to the invention, the additive material is introduced below the level of the material and/or material particles already in the receptacle (1).

Medical device for analyte monitoring and drug delivery

Delivering and/or receiving fluids

The present application generally relates to receiving bodily fluid through a device opening. The device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator.

Method and apparatus for transdermal stimulation over the palmar and plantar surfaces

Various methods and devices for providing transdermal electrical stimulation therapy to a patient are provided. In certain variations, a method may include positioning a stimulator electrode over a glabrous skin surface overlying a target nerve of a subject. Electrical stimulation may be delivered through or across the glabrous skin surface to the target nerve to stimulate the target nerve, while remaining safe and tolerable to the patient. Electrical stimulation may be delivered at frequencies that may be painful or intolerable when applied over non-glabrous surfaces of the body. Various applicators or devices for providing transdermal electrical stimulation therapy are also provided.

Sensor for measuring the activity of beta-pancreatic cells or of islets of Langerhans, manufacture and use of such a sensor

The invention relates to a sensor (2) including: a microelectrode assembly (21); and -pancreatic cells (23) or islets (230) of Langerhans in culture on the microelectrode assembly (21); characterized in that the microelectrode assembly (21) is designed to measure dynamically, continuously and in real time, electrical signals (V) produced by the -pancreatic cells (23) or the islets of Langerhans (230) upon physiological activation. The invention also relates to the field of devices that can be implantable in in the body of a patient, and including an insulin dispenser for dispensing an amount of insulin. The invention also relates to a method for manufacturing such a sensor and to such a device and a use of such a sensor.

Treatment delivery system

A system for delivering treatment to a biological subject, the system including: at least one substrate including a plurality of microstructures configured to breach a stratum corneum of the subject; at least one sensor operatively connected to at least one microstructure, the at least one sensor being configured to measure response signals from the at least one microstructure; at least one treatment delivery mechanism operatively coupled to at least one microstructure to deliver treatment via at least one microstructure; and, one or more electronic processing devices that are configured to control the at least one treatment delivery mechanism to thereby deliver treatment to the subject at least partially in accordance with the measured response signals.

Actuator system

A system for performing measurements on a biological subject, the system including: at least one substrate including a plurality of microstructures configured to breach a stratum corneum of the subject; and, an actuator configured to apply a force to the substrate to cause the microstructures to at least one of pierce and penetrate the stratum corneum.

DELIVERING AND/OR RECEIVING FLUIDS

The present application generally relates to receiving bodily fluid through a device opening. The device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator.

MICRONEEDLE FABRICATION AND DEVICE IMPLANTATION

Methods are provided for the fabrication of microneedles. Microneedles fabricated according to the herein described methods will generally be constructed of multiple lengths of wire winded together, brazed and further manipulated to include a reversible engagement feature. The subject microneedles may find use in a variety of applications and, among other purposes, the reversible engagement feature of such a microneedle may by employed in implanting an implantable device into a biological tissue. Also provided are methods of inserting an implantable device into a biological tissue having an outer membrane. The subject methods may include ablating a section of the outer membrane and inserting the implantable device through the ablated section of outer membrane, including e.g., where the implantable device is inserted using a microneedle including e.g., those microneedles for which methods of fabrication are provided herein.

DEVICES AND METHODS FOR THE INCORPORATION OF A MICRONEEDLE ARRAY ANALYTE-SELECTIVE SENSOR

A device (1300) and method (700) for the manual delivery of a therapeutic intervention in response to a physiological state of a user is disclosed herein. The device (1300) comprises a sensor (20), an infusion system, and a singular body-worn component (1305). The sensor (20) is configured to penetrate the stratum comeum to access the viable epidermis or dermis and measure the presence of an analyte. The infusion system is configured to deliver a solution-phase therapeutic agent based on an action of the user or a control algorithm.

A SYSTEM FOR DETERMINING FLUID LEVEL IN A BIOLOGICAL SUBJECT

A system for performing fluid level measurements on a biological subject, the system including at least one substrate including a plurality of microstructures configured to breach a stratum corneum of the subject, at least some microstructures including an electrode, a signal generator operatively connected to at least one microstructure to apply an electrical stimulatory signal to the at least one microstructure and at least one sensor operatively connected to at least one microstructure, the at least one sensor being configured to measure electrical response signals from at least one microstructure. The system also includes one or more electronic processing devices that determine measured response signals, the response signals being at least partially indicative of a bioimpedance and perform an analysis at least in part using the measured response signals to determine at least one indicator at least partially indicative of fluid levels in the subject.

SYSTEMS AND METHODS FOR NEUROLOGICAL TRAFFIC AND/OR RECEPTOR FUNCTIONAL EVALUATION AND/OR MODIFICATION

Systems and methods for controlled sympathectomy procedures for neuromodulation are disclosed. A system for controlled micro ablation procedures is disclosed. A guidewire including one or more sensors or electrodes for accessing and recording physiologic information from one or more anatomical sites within the parenchyma of an organ as part of a physiologic monitoring session, a diagnostic test, or a neuromodulation procedure is disclosed. A guidewire including one or more sensors and/or a means for energy delivery, for performing a neuromodulation procedure within a small vessel within a body is disclosed.

MEDICAL DEVICE FOR ANALYTE MONITORING AND DRUG DELIVERY

DELIVERING AND/OR RECEIVING FLUIDS

The present application generally relates to receiving bodily fluid through a device opening. The device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator.

DELIVERING AND/OR RECEIVING BODILY FLUIDS

The present application generally relates to receiving bodily fluid through a device opening. The device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator.

ALLERGY TESTING DEVICE AND METHOD OF TESTING FOR ALLERGIES

An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has at least one touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activators to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and/or discomfort during testing.

Wound dressing with impedance sensor

Integrated circuit module with lead frame display micromanipulation needle

Microelectrode array comprising connected microfibers

SENSOR FOR MEASURING A PATIENT'S INSULIN REQUIREMENTS AND MANUFACTURING METHOD THEREOF

SU-8 MICRONEEDLES FOR MONITORING AND STIMULATING NEURONS

The invention relates to an SU-8 microneedle for monitoring and stimulating neurons, having a thickness of less than 100 micrometres and a length of 50 micrometres to 10 centimetres, wherein the manufacturing method enables the microneedle to be removed from the substrate without using mechanical means due to the initial coating of a rigid substrate with a layer of aluminium as a sacrificial layer and the final chemical etching of the aluminium layer for chemically removing the microneedle obtained in known intermediate photolithographic manufacturing steps.

MICROPROBES

Microprobes for common mode noise reduction are described.

SYSTEMS AND METHODS FOR CREATING AND USING SUCTION BLISTERS OR OTHER POOLED REGIONS OF FLUID WITHIN THE SKIN

The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.

Silicon microprobe with integrated biosensor

Microprobe device 10 provides an analyte signal from biosensor 12 to an external analyte meter indicating analyte presence in an analyte-containing bodily fluid of a subject (not shown).

Device for creating a neural interface and method for making same

An implant device for creating a neural interface with the central nervous system having a polyimide-based electrode array is presented along with a method for making the device. The device may be configured as a three dimensional structure and is capable of sensing multi-unit neural activity from the cerebral cortex. Mechanical, electrical and biological characteristics of the device support its use as a reliable, long term implant.

Delivering and/or receiving fluids

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

Compartment Syndrome Monitoring Systems and Methods

Embodiments of a compartment monitor that can be implanted and left in situ to continuously (or semi-continuously) measure compartment pressures are presented. An exemplary monitor includes a pressure sensor adapted to be implanted in a compartment, a transmitter external to the compartment and coupled to the pressure sensor, and a receiver in communication with the transmitter to receive and process pressure data received from the transmitter. The monitor may also be configured to transmit measured pressure data to a networkable device. The networkable device can then communicate the patient's status and condition to a healthcare provider through a local area network (LAN) or wide area network (WAN). This communication allows the healthcare provider to remotely monitor a patient. The networkable device, or associated computing system, can record and display trends in the pressure data over time, and log the data to the patient's electronic health records.

Locatable Expandable Working Channel And Method

A method and device is provided for accessing a target location within a branched network. The device may be passed through the working channel of a standard endoscope and includes a three-dimensional location sensor at its distal tip and an expandable extended working channel. The device has a very thin body proximal of the distal sensor such that, once the sensor is extended outside of the working channel of the endoscope, nearly all of the working channel may be used to pass tools through the extended working channel of the device.

Catheter, a balloon catheter and a method and apparatus for monitoring the transverse cross-section of a stoma

A balloon catheter ( 1 ) comprises a catheter ( 2 ) and a balloon ( 6 ) located on the distal end of the catheter. A pair of stimulating electrodes ( 15 ) for receiving a constant current stimulating signal when the balloon ( 6 ) is inflated with an electrically conductive medium and a plurality of sensing electrodes ( 16 ) for producing voltage response signals are located on the catheter ( 2 ). The voltage response signals are indicative of the values of the transverse cross-sectional area of the balloon ( 6 ) adjacent the sensing electrodes ( 16 ). A first lumen < 9 ) accommodates the inflating medium to and from the balloon ( 6 ), and a second lumen ( 19 ) accommodates electrically conductive wires ( 18 ) to the stimulating and sensing electrodes ( 15,16 ). A pressure sensing dement ( 21 ) is located in a protective housing ( 22 ) in the second lumen ( 19 ), and communicates through a communicating opening ( 26 ) in the protective housing ( 22 ) and through a communicating port ( 24 ) in the catheter ( 2 ) with a hollow interior region ( 7 ) of the balloon ( 6 ).

Catheter with thin film pressure sensing distal tip

A mapping and ablation catheter has contact force sensing capabilities at a distal end. In one embodiment, the catheter includes a catheter body, a deflectable section, and a tip distal tip section which has a tip electrode with a thin-film pressure sensor that is adapted to detect a force vector applied to the tip electrode. The thin-film pressure sensor includes two opposing flexible and thin support members containing a pressure-sensitive material therebetween whose resistivity changes as a result of pressure and is detected by trace electrode intersections supported on interfacing surfaces of the flexible and thin support members. Used with a stop member having a conforming shape against which the thin-film pressure sensor abuts when a force vector is applied to the tip electrode, the pressure sensor can have a 2-D, radially-symmetrical shape, e.g., a disc or ring configuration, or a 3-D, radially-symmetrical shape, e.g., a conical configuration.

Reconfirmation of ecg-assisted catheter tip placement

Reconfirmation of the position of a catheter intravascularly placed with the assistance of ECG signals of the patient is disclosed, thus assisting in determination of subsequent catheter displacement within the patient vasculature. In one embodiment a method for reconfirming a position of an indwelling medical device within a body of a patient comprises first placing the medical device within the body of the patient using ECG signals of the patient. A first ECG signal profile relating to an initial position of the indwelling medical device after initial placement of the medical device is stored. A second ECG signal profile relating to the position of the indwelling medical device at a time subsequent to initial placement of the medical device is then acquired. The first ECG signal profile is compared with the second ECG signal profile to determine whether displacement of the indwelling medical device has occurred.

Method and System For Patient-Specific Modeling of Blood Flow

Embodiments include a system for planning treatment for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of an anatomical structure of the patient, create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data, and determine a first fractional flow reserve within the anatomical structure of the patient based on the three-dimensional model and information regarding a physiological condition of the patient. The at least one computer system may be further configured to receive input from a user regarding a plan of treatment, modify the physiological condition of the patient based on the received input, and determine a second fractional flow reserve within the anatomical structure of the patient based on the modified physiological condition of the patient.

Catheter with imaging assembly

A catheter with an imaging assembly is disclosed. The catheter is used with a console for viewing and/or storing images obtained from the catheter. The catheter may be a feeding tube assembly. The imaging assembly on the feeding tube assembly allows a user to confirm placement of the feeding tube assembly in the patient's alimentary canal.

Methods and systems for determining vascular bodily lumen information and guiding medical devices

Methods and systems for determining information about a vascular bodily lumen are described. An exemplary method includes generating an electrical signal, delivering the electrical signal to a plurality of excitation elements in the vicinity of the vascular bodily lumen, measuring a responsive electrical signal from a plurality of sensing elements in response to the delivered electrical signal, and determining a lumen dimension. Specific embodiments include generating a multiple frequency electrical signal. Another embodiment includes measuring a plurality of responsive signals at a plurality of frequencies. Still other embodiments include using spatial diversity of the excitation elements. Yet other embodiments use method for calibration and de-embedding of such measurements to determine the lumen dimensions. Diagnostic devices incorporating the method are also disclosed, including guide wires, catheters and implants. The methods and systems described herein are advantageous as they do not include injecting a second fluid for the measurements.

Systems and methods for analysis and treatment of a body lumen

A catheter for placement within a body lumen, the catheter including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end, at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a lumen-expanding inflatable balloon disposed about a portion of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located within the balloon; and, at least one elongate arm connected to the conduit and positioned within the balloon, the at least one elongate arm radially translatable with respect to the conduit, and wherein at least one of the transmission output and transmission input is coupled to the elongate arm.

Medical apparatus system having optical fiber load sensing capability

Apparatus is provided for diagnosing or treating an organ or vessel, wherein a device having at least two optical fiber sensors disposed in a distal extremity thereof is coupled to processing logic programmed to compute a multi-dimensional force vector responsive to detected changes in the optical characteristics of the optical fiber sensors arising from deflection of the distal extremity resulting from contact with the tissue of the wall of the organ or vessel. The force vector may be used to facilitate manipulation of the catheter either directly or automatically using a robotic system.

In-plane dual loop fixed diameter electrophysiology catheters and methods of manufacturing therefor

An EP catheter includes a tubular body having a proximal region, a neck region, and a distal portion predisposed into an in-plane dual loop (at least, approximately, more or less) configuration and including a plurality of diagnostic electrodes. In deflectable catheter forms, at least one activation wire extends through at least a portion of the proximal region of the catheter body and is adapted to deflect the distal portion up to approximately 180 degrees relative to the proximal region. The catheter can be operated manually by a clinician or via a clinician-surrogate such as a computer processor-controlled surgical system. In addition, a variety of localization, visualization, and/or orientation-specific elements can be incorporated into the devices described, depicted, and claimed herein (e.g., metallic coil members, active impedance emitting or receiving electrodes, fluoroscopically opaque materials, and the like).

Fixed loop deflectable electrophysiology catheters having an extended braid primary shaft coupled to the periphery of the fixed loop and methods of manufacturing therefor

An EP catheter includes a tubular body having a proximal region, a neck region, and a distal portion predisposed into a single shallow helical fixed-diameter loop configuration and including a plurality of diagnostic electrodes. In deflectable catheter forms, at least one activation wire extends through at least a portion of the proximal region of the catheter body and is adapted to deflect the up to approximately 180 degrees relative to the proximal region. The catheter can be operated manually by a clinician or via a clinician-surrogate such as a computer processor-controlled surgical system. In addition, a variety of localization, visualization, and/or orientation-specific elements can be incorporated into the devices described, depicted, and claimed herein (e.g., metallic coil members, active impedance emitting or receiving electrodes, fluoroscopically opaque materials, and the like).

Imaging guidewire

An imaging guidewire having at its distal tip at least a first Imaging sensor of a forward looking imaging system directed towards an area to be treated and configured to provide imaging data to a processing system, an optical imaging system directed towards an area that has already been treated and configured to provide imaging data of a treated area to the image processing system and at least one display device for displaying images processed by the image processing system. Operating the imaging guidewire during a medical procedure includes the steps of: Generating an image of an area to be treated; Upon completion of at least a portion of the medical treatment, generating an image of an area that has been treated; and displaying at least the first and second images; wherein each one of the first and second images can be generated by one or more imaging modalities.

Devices for diagnosing sleep apnea or other conditions and related systems and methods

A system includes a sensor device having a body configured to be inserted into an airway of a patient and one or more sensors mounted in or on the body. The one or more sensors are configured to collect sensor data associated with the airway of the patient. The system also includes a signal analyzer configured to analyze the sensor data. The one or more sensors could include one or more microphones. The signal analyzer could identify volume and/or pitch characteristics of the sensor data, perform pattern recognition to identify one or more patterns using the volume and/or pitch characteristics, and use the one or more patterns to identify a type, a location, and/or a degree of airway obstruction. This could be done, for instance, to determine if the patient suffers from obstructive sleep apnea or other condition that affects his or her airway.

Method and apparatus for performing transesophageal cardiovascular procedures

An apparatus for performing a transesophageal cardiovascular procedure includes an elongated tubular main access device having a first lumen with an open proximal end and a distal side opening, and a second lumen with a rigid outer wall and a collapsible inner wall. The second lumen is adapted to receive an elongated probe or surgical device. The apparatus further includes an inflatable sealing means on the outside of the main access device above and below the side opening, and a first fluid conduit extending along the main access device for inflating the sealing means so that when the main access device is inserted into a patient's esophagus and the sealing means are inflated. The portion of the esophagus opposite the side opening is isolated from the remainder of the esophagus above and below the side opening.

Endoscope system, processor of endoscope system, and image producing method

First illumination light of a first wavelength range, in which light absorption coefficient of blood hemoglobin varies with oxygen saturation thereof, is projected into a test subject body, to capture a first image signal from the first illumination light as reflected from inside the test subject body. Then second illumination light of a second wavelength range different from the first wavelength range is projected into a test subject body, to capture a second image signal from the second illumination light as reflected from inside the test subject body. A subject image of the test subject is produced from the second image signal. Oxygen saturation levels of the test subject are calculated using the first and second image signals. According to the calculated oxygen saturation levels, color properties of the subject image are changed to produce an oxygen saturation image.

Micro-fluidic test apparatus and method

An apparatus, system, and method for determining the osmolarity of a fluid. The apparatus includes at least one micro-fluidic circuit and at least one electrical circuit disposed in communication with the micro-fluidic circuit for determining a property of a fluid contained within the at least one micro-fluidic circuit.

Actively Mode Locked Laser Swept Source for OCT Medical Imaging

An optical coherence analysis system uses a laser swept source that is constrained to operate in a mode locked condition. This is accomplished by synchronously changing the laser cavity's gain and/or phase based on the round trip travel time of light in the cavity. This improves high speed tuning by taking advantage of frequency shifting mechanisms within the cavity and avoids chaotic laser behavior.

Assembly with Imaging Electronics

A catheter with an imaging assembly is disclosed. The catheter is used with a console for viewing and/or storing images obtained from the catheter. The catheter may be a feeding tube assembly. The imaging assembly on the feeding tube assembly allows a user to confirm placement of the feeding tube assembly in the patient's alimentary canal.

System for continuous measuring, recording and monitoring of the splanchnic tissue perfusion and the pulmonary physiological dead space, and use thereof

The present invention relates to a new system for measuring, recording and monitoring the splanchnic tissue perfusion and the pulmonary physiological dead space in an automated way, both continuously and intermittently, and in real time, which is easy to manage and generates information easy to interpret. Said system comprises at least four measuring devices of medical parameters, connected to a device receiving, converting, storing, integrating, processing, and allowing the management and display of the data recorded in the measurements and the parameters estimated by the same. For this purpose, said device comprises a specific computer program of estimation of parameters related to the measurement of the splanchnic tissue perfusion and the pulmonary physiological dead space, from the data derived from the measuring devices. Likewise, the present invention is related to the use of a device for measuring, recording and monitoring of the splanchnic tissue perfusion and the pulmonary physiological dead space.

Temperature measuring device

An apparatus for accurately measuring the body temperature of a patient at the tracheal wall of the patient. The apparatus includes a novel handheld temperature readout assembly that is easy to use by the caregiver and one which clearly and accurately displays the temperature of the patient. The handheld temperature readout assembly includes a handheld housing having a viewing window and a light emitting diode temperature display that is carried by the housing and is readily viewable through the viewing window of the handheld housing for displaying the patient temperature. The apparatus also includes a built-in alarm system to alert to high and low body temperatures.

Imaging apparatus for diagnosis and control method thereof

An imaging apparatus for diagnosis is connected with a probe including a transmitting and receiving unit transmitting a light transmitted from a light source continuously to the inside of a body cavity and concurrently, receiving a reflected light continuously from the inside of the body cavity, and generates a tomographic image inside the body cavity based on the obtained reflected light by obtaining the reflected light from the transmitting and receiving unit while rotating the transmitting and receiving unit. The apparatus comprises: a mechanism for extracting intensity of the reflected light obtained by a phenomenon that the light transmitted to the transmitting and receiving unit is reflected at the transmitting and receiving unit; and a mechanism for judging whether or not the extracted intensity of each reflected light at each rotary angle of the transmitting and receiving unit lies in a range of a predetermined variation width.

Apparatus and methods for treating obstructions within body lumens

Apparatus and methods are provided for delivering fluid into a body lumen during a medical procedure. A distal end of an apparatus may be introduced into a body lumen, and a valve on the distal end may be opened to deliver fluid through a first lumen into the body lumen, e.g., contrast and/or other diagnostic or therapeutic agents. The valve may be closed, and a procedure may be performed within the body lumen, e.g., using a treatment element carried on the distal end. For example, the treatment element may include a balloon that may be inflated when fluid is delivered through the first lumen with the valve closed. Optionally, a prosthesis, energy source, drug platform, and the like may be carried by the balloon for treating the body lumen. In various embodiments, the valve may be located proximal or distal to the treatment element.

Transceiver unit in a measurement system

A measurement system may comprise a sensor wire and a transceiver unit. The sensor wire may comprise an insertable portion configured to be inserted in a blood vessel of a patient's body and a sensor disposed within the insertable portion at a distal end of the sensor wire. The sensor is configured to measure a parameter when inserted inside the patient. The transceiver unit may comprise: a housing adapted to be connected to a proximal end of the sensor wire; and a first communication module within the housing adapted to wirelessly communicate by a communication signal with an external second communication module in order to transfer information to the external second communication module.

Method and Apparatus for Measuring Blood Volume

In one aspect, a conductance catheter is provided for measuring the volume of a fluid. The conductance catheter comprises a series of electrodes and a circuit to compensate for variations in sensitivity of the electrodes in the catheter. In another aspect, a resistivity sensor is provided for determining the resistivity of a fluid. The sensor comprises a series of electrodes spaced such that the total distance between endmost electrodes does not exceed the diameter of the catheter deploying the sensor.

Magnetically guided catheters

A magnetically-guided catheter 100 includes a tip positioning magnet in the distal electrode assembly configured to interact with externally applied magnetic fields for magnetically-guided movement. A magnetically-guided mapping catheter 100 includes an electrically-conductive capsule in the form of a casing 146 that includes a distal ablation surface and isolates the positioning magnet from bio-fluids to prevent corrosion. An open irrigation ablation catheter includes an isolated manifold that isolates the positioning magnet from contact with irrigation fluid to prevent corrosion.

Method and Apparatus for Cervical Cancer Screening

The present invention relates to an apparatus for cervical cancer screening, comprising one or more light sources aligned with a beginning of a first optical test path and a beginning of a second optical test path, one or more optical detectors aligned with an end of the first optical test path and an end of the second optical test path, and a processor coupled to the one or more light sources and the one or more optical detectors and methods for using the same. The present invention further relates to a method for cervical cancer screening.

System and Method for Registration of Multiple Navigation Systems to a Common Coordinate Frame

A method of registering two or more localization systems utilizing unique coordinate frames A and B to a common coordinate frames includes measuring position information for one or more reference locations r in each coordinate frame (e.g., A r and B r ). For each reference location, a fiducial grouping is created from the respective position measurements (e.g., (A r , B r )). The fiducial groupings are used to generate a mapping functionfthat transforms position measurements expressed relative to the second coordinate frame B to the first coordinate frame A. The mapping function f is defined such that a distance between f(B r ) and A r is about zero for each reference location r. Each localization system may also measure position information for a respective fixed reference localization element. Divergence between these fixed reference localization elements in the common coordinate system may be used to monitor, signal, and correct for anomalies such as dislodgement and drift.

Methods for detection of cardiac rhythm disorders using basket style cardiac mapping catheter

A method for sensing multiple local electric voltages from endocardial surface of a heart, includes: providing a system for sensing multiple local electric voltages from endocardial surface of a heart, including: a first elongate tubular member having a lumen, a proximal end and a distal end; a basket assembly including: a plurality of flexible splines for guiding a plurality of exposed electrodes, the splines having proximal portions, distal portions and medial portions therein between, wherein the electrodes are substantially flat electrodes and are substantially unidirectionally oriented towards a direction outside of the basket.

System and method for reconstructing cardiac activation information

An example system and method of reconstructing biological activation information are disclosed. A first biological signal and a second biological signal associated with an organ are processed via a computing device to determine whether there is a point of change in a derivative of the first biological signal with respect to a derivative of the second biological signal above a threshold. An activation onset time is assigned in the first biological signal at the point of change to define biological activation associated with the organ in the first cardiac signal if it is determined that the point of change is above the threshold.

Probes having deployable sites and methods for making the same

A probe for interfacing with biological tissue includes a shank. A site to receive a signal from or stimulate the biological tissue is deployably connected to the shank. An insulated interconnect is connected to the site to guide signals or a fluid between the site and the shank. An actuator displaces the site away from a protected position on the shank to a deployed position in the biological tissue to be monitored or stimulated by the site.

Hybrid three-dimensional sensor array, in particular for measuring electrogenic cell assemblies, and the measuring assembly

The invention relates to a hybrid three-dimensional sensor array, in particular for measuring biological cell assemblies. The sensor array has a plurality of microstructured sensor plates, each having one carrier section on which a plurality of sensor needles are arranged in a comb-like manner, which carry a plurality of electrode surfaces. Furthermore, a plurality of spacer elements are provided, which are fastened between the sensor plates so that both the carrier sections and the sensor needles of adjacent sensor plates are at a distance from each other. The invention further relates to a measuring assembly for measuring electrical activities of biological cell assemblies using such a sensor array.

Contact sensor and sheath exit sensor

A system and method is provided that allows for determining the local impedance of one or more electrodes of an electrode catheter. Such local impedance may be utilized to identify the relative position of an electrode catheter to a sheath of a guiding introducer. In another arrangement, local impedance of a catheter electrode can be utilized to calibrate a catheter electrode to provide improved contact sensing.

System and method for mapping gastro-intestinal electrical activity

A gastro-electrical activity mapping system and comprises a catheter insertable through a natural orifice into the gastro-intestinal (GI) tract and comprising an array of electrodes for contacting an interior surface of a section of the GI tract to detect electrical potentials at multiple electrodes, and a signal analysis and mapping system arranged to receive and process electrical signals from multiple electrodes of the array and spatially map GI smooth muscle electrical activity as an activation time map, a velocity map, or an amplitude map, which may be in the form of contour plots and may be mapped on an anatomical computer model of at least the section of the GI tract and may be animated. A GI mapping method and catheter are also claimed.

Stimulation/sensing lead adapted for percutaneous insertion

The present invention relates to a percutaneous insertion-capable lead, wherein insertion made through a percutaneous insertion structure. For one embodiment of such lead, the electrode-supporting stimulation portion of the lead includes at least one waisted region, relative to a transverse dimension of the lead, to facilitate lead steerability.

Method and system for patient-specific modeling of blood flow

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Method and system for patient-specific modeling of blood flow

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

CATHETER FOR MEASURING ELECTRIC POTENTIAL

A highly safe catheter that measures electric potential can be inserted into a cardiac chamber together with a balloon-tip ablation catheter and is able to prevent abnormal heat generation at electric potential-measuring electrodes even when high-frequency current is distributed. The catheter includes a shaft having electric potential-measuring electrodes, a metal portion with a length of 2 mm or more, and a lumen passing therethrough from a proximal end to a distal end in the longitudinal direction; and a metal wire inserted through the lumen and connected to the metal portion. 1. A catheter that measures electric potential comprising:a shaft having electric potential-measuring electrodes, a metal portion with a length of 2 mm or more, and a lumen passing therethrough from a proximal end to a distal end in a longitudinal direction; anda metal wire inserted through said lumen and connected to said metal portion.2. The catheter according to claim 1 ,wherein said electric potential-measuring electrodes are attached at a distal side in the longitudinal direction of said shaft, andsaid metal portion is located distally relative to a position of said electric potential-measuring electrodes in the longitudinal direction of said shaft.3. The catheter according to claim 1 , wherein said metal portion has a length of 2 to 50 mm.4. The catheter according to claim 1 , wherein said metal wire is electrically insulated.5. A catheter that measures electric potential comprising a metallic shaft having electric potential-measuring electrodes and a lumen extending in a longitudinal direction.6. The catheter according to claim 5 , wherein said metallic shaft is obtained by forming a metal wire into a coil shape.7. The catheter according to claim 5 , wherein said metallic shaft is electrically insulated.8. A balloon-tip ablation catheter system comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the catheter according to ;'}a balloon-tip ablation catheter comprising a lumen ...

DETECTING AND TREATING NERVOUS SYSTEM DISORDERS

Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium. 1. A method of using a catheter device to provide intravenous brain mapping from within one or more cerebral veins , comprising:advancing a distal tip portion of a brain mapping catheter device through a patient's vein that extends below the patient's head to a position within one or more cerebral veins proximal to brain tissue within the patient's head, wherein the brain mapping catheter device accesses the one or more cerebral veins without surgical access through an opening in the patient's cranium; andusing one or more electrodes positioned along the distal tip portion of the brain mapping catheter device to detect electrophysiological signals in a portion of the brain tissue while the one or more electrodes remain disposed within the one or more cerebral veins and while a proximal portion of the brain mapping catheter device resides external to the patient.2. The method of claim 1 , further comprising electrically coupling at least one component of the proximal portion of the brain mapping catheter device to an electrophysiological mapping control and display system.3. The method of claim 2 , wherein the brain mapping catheter device comprises a flexible elongated body having an internal conduit through which ...

Methods and systems for detection and thermal treatment of lower urinary tract conditions

The invention is directed to a method for treating a urinary system. The method includes positioning one or more treatment units with respect to an organ wall. The one or more treatment units may be configured to deliver thermal energy. The method further includes delivering energy through the one or more treatment units to heat tissue of the organ wall.

Medical devices including ablation electrodes

Medical devices and methods for making and using medical devices are disclosed. An example medical device may be a renal nerve modulation catheter. The catheter may include an elongate catheter shaft. The catheter shaft may have a plurality of cuts formed therein define a plurality of electrode assemblies. The electrode assemblies may each include a main strut, one or more branched spacer struts extending from the main strut, and an electrode extending from the main strut and positioned radially inward from the spacer struts.

DEVICE AND METHODS FOR MEASURING AND TREATING AN ANATOMICAL STRUCTURE

A sensor delivery device and methods of using the device are provided, wherein the sensor delivery device includes a sensor that is adapted to obtain a measurement that can be used to calculate cross-sectional area of a surrounding anatomical structure. In certain cases, the sensor is an electrode arrangement, wherein the electrode arrangement generates a current and measures voltage resulting from the current. The voltage measurement is then used to calculate conductivity of fluid in the surrounding anatomical structure and thus cross-sectional area. 1. An intravascular sensor delivery device comprising:a distal sleeve having a guidewire lumen for slidably receiving a medical guidewire;a first sensor coupled to the distal sleeve, wherein the first sensor is adapted to measure blood pressure and generate a signal representative of the blood pressure;a second sensor coupled to the distal sleeve, wherein the second sensor is adapted to measure cross-sectional area of a surrounding anatomical structure and generate a signal representative of the cross-sectional area;a proximal portion coupled to the distal sleeve, the proximal portion comprising a communication channel, wherein the communication channel communicates the signal from the first sensor and the signal from the second sensor to a location outside of the patient.2. The device of wherein the second sensor comprises an electrode arrangement.3. The device of wherein the electrode arrangement includes source electrodes and sense electrodes claim 2 , wherein the source electrodes generate a current and the sense electrodes measure voltage resulting from the current.4. The device of wherein the signal representative of the cross-sectional area is the voltage measured by the sense electrodes.5. The device of wherein the electrode arrangement includes two source electrodes and two sense electrodes.6. The device of wherein the source electrodes and the sense electrodes are ring-shaped electrodes that surround a ...

INTERVENTIONAL PHOTOACOUSTIC IMAGING SYSTEM

An interventional photoacoustic imaging system and method for cancer treatment comprises an optical source for applying laser energy to optically excite a treatment area, a needle, ablation tool or catheter for inserting the optical source into a body of a patient adjacent the treatment area, and an ultrasonic transducer for detecting the acoustic waves. A processor receives the raw data from the ultrasound system and processes it to thereby form a photoacoustic image of the tissue in real time. As such, image formation may be performed preoperatively, intraoperatively, and postoperatively. 1. An interventional photoacoustic imaging system for cancer treatment , comprising:an energy source including an optical source for applying laser energy to optically excite a treatment area;means for inserting the optical source into a body of a patient adjacent the treatment area;an ultrasonic transducer for detecting the acoustic waves; anda processor for analyzing the acoustic waves to thereby form a photoacoustic image of the tissue in real time.2. The interventional photoacoustic imaging system of claim 1 , wherein said inserting means is a needle and said optical source is an optical fiber coupled within a shaft of the needle claim 1 , said optical source operatively connected to a pulsed laser source.3. The interventional photoacoustic imaging system of claim 1 , wherein said inserting means is a brachytherapy needle claim 1 , a biopsy needle or an ablation tool.4. The interventional photoacoustic imaging system of claim 1 , wherein said inserting means is a needle and said optical source is an optical fiber disposed on an outer surface of a shaft of the needle claim 1 , said optical source operatively connected to a pulsed laser source.5. The interventional photoacoustic imaging system of claim 4 , wherein said inserting means is a brachytherapy needle claim 4 , a biopsy needle or an ablation tool.6. The interventional photoacoustic imaging system of claim 5 , wherein ...

Systems and Methods for Visualizing Ablated Tissue

Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue includes a catheter having an expandable balloon at a distal end, an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue, and an imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera. 1. A system for imaging tissue comprising:a catheter having an expandable balloon at a distal end;an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native reduced nicotinamide adenine dinucleotide (NADH) in the tissue; andan imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera.2. The system of further comprising an ablation device for ablating the tissue.3. The system of claim 1 , wherein the tissue being treated is heart tissue.4. The system of further comprising a display system connected to the camera for generating an image of the illuminated tissue based on the detected NADH fluorescence.5. The system of claim 4 , wherein in the image tissue that was effected by a treatment is illustrated as having less fluorescence than tissue not affected by the treatment6. The system of further comprising a dichroic mirror and a plurality of filters for conditioning light from the light source and light reflected by the tissue.7. A system for imaging tissue comprising:a catheter system configured to position an illumination device and an imaging device in proximity to a tissue;an ablation device ...

BASKET STYLE CARDIAC MAPPING CATHETER HAVING A FLEXIBLE ELECTRODE ASSEMBLY AND AN ATRAUMATIC TIP FOR DETECTION OF CARDIAC RHYTHM DISORDERS

A system for sensing multiple local electric voltages from endocardial surface of a heart, includes: an elongate tubular member; a plurality of flexible splines having proximal portions, distal portions and medial portions therein between; an anchor for securably affixing the proximal portions of the splines; an atraumatic tip for securably affixing the distal portions of the splines; and a polymeric member including opposed a first open end and a second open end defining an open lumen therein between and an inner member surface and an outer member surface, wherein at least one of the plurality of flexible splines is at least partially disposed within the lumen of the polymeric member; a flexible electrode assembly strip with one or more exposed electrodes disposed on at least a portion of the outer surface of the polymeric member. 130.-. (canceled)31. A system for sensing multiple local electric voltages from endocardial surface of a heart , comprising:a first elongate tubular member having a lumen, a proximal end and a distal end; a plurality of flexible splines having proximal portions, distal portions and medial portions therein between, wherein the splines comprise an outer surface, an inner surface and two side surfaces, and wherein the splines further comprise alignment members projecting laterally outwardly from the two side surfaces at the distal portions of the splines;', 'a proximal anchor for securably affixing the proximal portions of the splines, wherein the anchor is securably affixed within the lumen of the elongate tubular member at the distal end of the first elongate tubular member;', 'a distal tip having a plurality of channels, each of the channels having a distal portion of one of the plurality of the splines disposed thereat, said tip further comprising a central spline alignment portion, wherein the alignment members of the splines are securably disposed within the spline alignment portion of the distal tip; wherein said proximal anchor and ...

FLUOROSCOPY-INDEPENDENT, ENDOVASCULAR AORTIC OCCLUSION SYSTEM

A system for deploying and selectively inflating a thoracic aortic balloon at a desired location within the thoracic aorta for resuscitative aortic occlusion, inferior to the left subclavian artery, without the aid of fluoroscopy is described. Using CT imaging data, a distance between readily identifiable and consistently located external landmarks of torso extent is measured. Next, using the same data, a second distance from the femoral artery to a desired aortic occlusion location inferior to the left subclavian artery is determined. A correlation between the external measure of torso extent and the desired intra-arterial (i.e. endovascular) distance within the torso is made. Using a nomogram, a calibrated endovascular resuscitative thoracic aortic occlusion system can be positioned to this desired location on any injured individual with end-stage shock and impending cardiovascular collapse or death without the aid of fluoroscopy for delivery or balloon inflation. 114-. (canceled)15. A system for determining a length to which an endovascular wire and a balloon shaft of a thoracic aortic occlusion system are to be inserted into a femoral artery at a femoral head of a patient , thereby positioning the aortic occlusion balloon in a thoracic aorta inferiorly of a left subclavian artery of the patient without fluoroscopy , comprising:measuring a distance between at least two anatomical landmarks of the patient, said anatomical landmarks including at least a symphysis pubis of the patient and a sternal notch of the patient; andcomparing the distance between the at least two external anatomical landmarks of the patient to a nomogram, the nomogram including one of a table, chart or graph correlating distances between the at least two external anatomical landmarks of a pool of humans to centerline distances from the femoral artery at the femoral head to a location within the thoracic aorta of the humans, to calculate the length to which the endovascular wire and the ...

SENSOR JACKET

A sensor guide wire for intravascular measurement of a physiological variable includes a sensor element arranged in a jacket in a sensor region of the sensor guide wire, a core wire extending at least partly along the length of the sensor guide wire, and at least one electrical lead connected to the sensor element. The jacket is tubular and includes proximal and distal end openings, a jacket wall, a first opening arranged in the jacket wall, and a second opening arranged in the jacket wall. The first and second openings are proximate to the sensor element, and the core wire is adapted to extend through the jacket via the proximal and distal end openings. The sensor guide wire can provide a more reliable and stable sensor output by preventing air from becoming entrapped within the jacket wall or allowing such entrapped air to escape. The sensor guide wire may also prevent air from adhering to the outer surface of the jacket wall by enabling improved fluid communication between the sensor element and a fluid medium. 113.-. (canceled)14. A sensor guide wire for intravascular measurement of a physiological variable , comprising:a sensor element arranged in a jacket in a sensor region of the sensor guide wire;a core wire extending at least partly along a length of the sensor guide wire; andat least one electrical lead connected to the sensor element;wherein the jacket is tubular and includes proximal and distal end openings, a jacket wall, a first opening arranged in the jacket wall, and a second opening arranged in the jacket wall, the first and second openings being proximate to the sensor element; andwherein the core wire is adapted to extend through the jacket via the proximal and distal end openings.15. The sensor guide wire according to claim 14 , wherein the second opening is arranged at the opposite side of the jacket in relation to the first opening.16. The sensor guide wire according to claim 14 , wherein the jacket has a longitudinal axis claim 14 , and ...

Method and apparatus for performing transesophageal cardiovascular procedures

An apparatus for performing a transesophageal cardiovascular procedure includes an elongated tubular main access device having a first lumen with an open proximal end and a distal side opening, and a second lumen with a rigid outer wall and a collapsible inner wall. The second lumen is adapted to receive an elongated probe or surgical device. The apparatus further includes an inflatable sealing means on the outside of the main access device above and below the side opening, and a first fluid conduit extending along the main access device for inflating the sealing means so that when the main access device is inserted into a patient's esophagus and the sealing means are inflated. The portion of the esophagus opposite the side opening is isolated from the remainder of the esophagus above and below the side opening.

ELECTROANATOMICAL MAPPING

This invention relates to the determination and/or representation of physiological information relating to a heart surface. 175-. (canceled)76. A method for providing an electroanatomical representation of a patient's heart , the method comprising:measuring signals at one or more electrodes at multiple positions in the patient's heart cavity over a time period including multiple heart beat cycles, at least some of the signals being in response to electrical activity in the patient's heart cavity;selecting portions of one or more specific signals to process to determine a triggering event based on a second, different signal of the measured signals;applying an algorithm to the selected portions of the one or more specific signals of the measured signals to determine the triggering event in the specific signal;synchronizing, by the computer, the signals measured at the one or more electrodes with one another according to a heart beat cycle based on the triggering event; andgenerating, by the computer, the electroanatomical representation of the patient's heart based on the synchronized measured signals and positions of the catheter electrodes.77. (canceled)78. The method of claim 76 , wherein selecting portions of the specific signal comprises selecting portions of the specific signal to exclude from processing.79. The method of claim 76 , wherein selecting portions of the specific signal comprises selecting portions of the specific signal to include in processing.8084-. (canceled)85. The method of claim 76 , wherein the one or more electrodes comprise one or more electrodes on an intracardiac catheter.86. The method of claim 76 , further comprising:generating, by the computer, annotation information for the measured signals by applying one or more algorithms to the measured signals.87. The method of claim 86 , further comprising conveying at least some of the annotation information to the user.88. The method of claim 76 , further comprising:inserting a catheter ...

RENAL FUNCTION ANALYSIS METHOD AND APPARATUS

A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule. 130-. (canceled)31. An apparatus for analyzing the condition of a kidney , said apparatus comprising:a source of a kidney function analysis composition, said composition comprising a plurality of fluorescent reporter molecules and a plurality of fluorescent marker molecules, said reporter molecules and said marker molecules sharing a molecular property;a catheter for introducing the analysis composition into the blood steam of a patient; anda detector for monitoring the level of the analysis composition within the blood stream and reporting the operating condition of the kidney;wherein the volume of plasma distribution based on the fluorescent of the marker molecules relative to the fluorescence of the reporter molecules is calculated and reported as a measure of kidney function and condition.32. The apparatus of wherein the molecular property is selected from the group consisting of molecular weight claim 31 , size claim 31 , shape claim 31 , charge claim 31 , fluorescence and radio frequency.33. The apparatus of wherein the molecular property is fluorescence claim 32 , the reporter molecule has a first fluorescence claim 32 , and the marker molecule has a second fluorescence.34. The apparatus of wherein the molecular property is molecular weight claim 32 , the reporter molecule has a first molecular weight claim 32 , and the marker molecule has a second molecular weight which is greater than the molecular weight of ...

SYSTEM FOR IDENTIFYING THE LOCATION OF A DEVICE WITHIN A PATIENT'S BODY IN ORDER TO LOCATE THE FOSSA OVALIS FOR TRANS-SEPTAL PROCEDURES

A system and method for identifying the location of a medical device within a patient's body may be used to localize the fossa ovalis for trans-septal procedures. The systems and methods measure light reflected by tissues encountered by an optical array. An optical array detects characteristic wavelengths of tissues that are different distances from the optical array. The reflectance of different wavelengths of light at different distances from an optical array may be used to identify the types of tissue encountered, including oxygenated blood in the left atrium as detected from the right atrium through the fossa ovalis. 1. A medical device for identifying the location of a medical device within a patient's body comprising:an intravascular catheter;an optical array comprising a light emitter and a plurality of receivers for detecting reflected light, wherein two or more of the plurality of receivers are each positioned at different distances from the emitter; anda spectrometer in communication with the emitter and the plurality of receivers.2. The medical device of claim 1 , wherein the optical array further comprises a face plate claim 1 , wherein the emitter and each of the plurality of receivers are located on the face plate.3. The medical device of claim 1 , wherein the catheter further comprises a lumen and the face plate is annular and surrounds an opening to the lumen at a distal region of the catheter.4. The medical device of claim 3 , wherein the catheter has a longitudinal axis and the annular face plate lies in a plane that is substantially orthogonal to the longitudinal axis of the catheter.5. The medical device of claim 4 , wherein the emitter and plurality of receivers are positioned radially around the lumen on the face plate.6. The medical device of claim 5 , wherein the plurality of receivers comprises at least a first receiver claim 5 , a second receiver claim 5 , and a third receiver.7. The medical device of claim 6 , wherein the first receiver ...

OCCLUSION-CROSSING DEVICES, ATHERECTOMY DEVICES, AND IMAGING

Described herein are methods for producing and identifying characteristic (“crescent shaped”) regions indicative of an atherectomy plaque within a vessel, and systems and devices adapted to take advantage of this characteristic region. 1. A method of identifying an atherectomy plaque mass within a vessel , the method comprising:applying circumferential radial force within the vessel to displace a rigid plaque mass and force the vessel wall to stretch away from the device;imaging the vessel to create an image; andidentifying crescent-shaped structures associated with an atherectomy plaque in the image.2. The method of claim 1 , further comprising identifying the orientation of a plaque mass based on the directionality of the crescent-shaped structures.3. The method of claim 1 , further comprising identifying the position of a plaque mass relative to outer layered structures of a vessel wall based on the crescent-shaped structures.4. The method of claim 1 , wherein imaging the vessel comprises imaging the vessel with optical coherence tomography.5. The method of claim 1 , further comprising inserting a device into the vessel claim 1 , the device applying the circumferential radial force.6. The method of claim 5 , wherein imaging the vessel comprises imaging with an imaging sensor attached to the device.7. The method of claim 6 , further comprising orienting the device within the vessel based on the crescent-shaped structures.8. The method of claim 7 , wherein orienting the device comprises pointing a directional cutter at a plaque mass identified based upon the crescent-shaped structure.9. The method of claim 7 , wherein orienting the device comprises directing the device based upon the relationship between markers in the image and the crescent-shaped structures.10. The method of claim 6 , further comprising rotating the imaging sensor to obtain the image.11. An atherectomy device having a distal end configured to dissect plaque from within a vessel claim 6 , the ...

MEDICAL DEVICE HAVING A LUBRICIOUS COATING WITH A HYDROPHILIC COMPOUND IN AN INTERLOCKING NETWORK

A medical device having a lubricious coating on at least a section of the medical device, and a method of coating a medical device, the lubricious coating being a network of short chain and long chain hydrophilic compounds cross-linked to one another and interlocked with a network of a cross-linked polymerized multifunctional monomer or polymer. The coating can include one or more agents which provide enhanced adhesion of the coating on the device, or which provide faster hydration of the coating and/or improved lubricity. Additionally, the lubricious coating can be provided with one or more therapeutic or diagnostic agents, and in one embodiment the agent elutes relatively quickly in a concentrated release from the lubricious coating upon hydration of the coating. 1. A medical device having at least a section with a lubricious coating that comprises the cured reaction product of a solution mixture applied to the device , the solution mixture , comprising:a) a multifunctional monomer or polymer network-forming compound;b) a short chain hydrophilic compound;c) a long chain hydrophilic compound;d) one or more first cross-linkers for cross-linking the multifunctional monomer or polymer, which preferentially cross-links the multifunctional monomer or polymer relative to the hydrophilic compounds; ande) one or more second cross-linkers, different than the first cross-linkers, for cross-linking the hydrophilic compounds, which preferentially cross-links the hydrophilic compounds relative to the multifunctional monomer or polymer, such that the cured reaction product on the medical device is a network of the hydrophilic compounds cross-linked to one another and interlocked with a polymerized network of the monomer or polymer.2. The method of claim 1 , wherein the lubricious coating is cured using a radiation source.3. The method of claim 1 , wherein the lubricious coating is cured using an ultraviolet source.4. The method of claim 1 , wherein the lubricious coating is ...

FLOW REDUCTION HOOD SYSTEMS

Flow reduction hood systems are described which facilitate the visualization of tissue regions through a clear fluid. Such a system may include an imaging hood having one or more layers covering the distal opening and defines one or more apertures which control the infusion and controlled retention of the clearing fluid into the hood. In this manner, the amount of clearing fluid may be limited and the clarity of the imaging of the underlying tissue through the fluid within the hood may be maintained for relatively longer periods of time by inhibiting, delaying, or preventing the infusion of surrounding blood into the viewing field. The aperture size may be controlled to decrease or increase through selective inflation of the membrane or other mechanisms. 1. An apparatus configured to control fluid flow for visualization , comprising:a barrier projecting distally from a deployment catheter and defining an open area therein, wherein the open area is in fluid communication with at least one lumen defined through the catheter;at least one membrane extending over a distal opening defined by the barrier such that the membrane partially covers the open area and further defines at least one aperture through the membrane, wherein the aperture has a size which is less than a diameter of the membrane to control a flow of a clearing fluid through the aperture and to an environment external to the barrier, the fluid being infused within the open area via the at least one lumen; andan imaging element positioned to image the open area through the clearing fluid.2. The apparatus of further comprising an energizable element positioned proximal to the aperture.3. The apparatus of wherein the energizable element is advanceable through the open area.4. The apparatus of wherein the energizable element positioned within the open area.5. The apparatus of wherein the energizable element is energized via RF energy.6. The apparatus of wherein the aperture is controllable to variably alter ...

Medical device comprising a multipart housing

A medical device for carrying out at least one medical function, comprising at least one element that can be at least partially inserted into a body tissue of a user and further comprising at least one housing that can be placed on a skin surface of the user. The housing has a multipart design and comprises at least one functional component. The functional component can be connected to the insertable element. The housing further comprises at least one protective component. The protective component is designed to at least partially enclose the functional component. The protective component can be connected to the functional component, particularly after insertion of the insertable element.

Intravascular sensing method and system

Methods and systems for calculating a corrected Fractional Flow Reserve. Methods include delivering a pressure sensing device including a pressure sensor to a location in an artery having a stenosis, positioning the pressure sensor distal to the stenosis, measuring the distal pressure, measuring the proximal pressure, and calculating a corrected Fractional Flow Reserve using the measured proximal and distal pressures and applying a correction factor or correction equation. The correction factor or correction equation corrects for changes in the measured distal pressure caused by a presence of the pressure sensing device. A data set of correction factors or correction equations may be stored in a memory component of the system. The corrected Fractional Flow reserve may approximate the Fractional Flow Reserve that would be obtained if a different sized device was used to measure the distal pressure, such as a pressure sensing guidewire having a 0.014 inch outer diameter.

GUIDEWIRE HAVING LINEAR CHANGE IN STIFFNESS

The invention is directed to a guidewire having a distal section with multiple distally tapered core segments with at least two contiguous distally tapering core segments in which the most distal tapered core segment preferably has a greater degree of taper than the proximally contiguous tapered core segment. The invention is also directed to an elongated intracorporeal device, preferably a guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal section of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that preferably is configured to produce a linear change in stiffness of the core over a longitudinal section of the device. 163-. (canceled)64. A guidewire , comprising:an elongated core member having a substantially constant change in bending stiffness based on relative bending stiffness values of the elongated core member versus axial position values along the core member.65. The guidewire of claim 64 , wherein the slope of a graph of the bending stiffness values of the elongated core member versus the axial position values of the core member is constant.66. The guidewire of claim 64 , wherein the elongated core member is comprised of multiple core segments claim 64 , at least some of the multiple core segments having a constant taper angle along a length thereof.67. The guidewire of claim 66 , wherein the elongated core member has a distal end and a proximal end; the constant taper angle of each of the at least some of the multiple core segments being greater than the constant taper angle proximally adjacent thereto.68. The guidewire of claim 64 , wherein the elongated core member is comprised of multiple core segments each having a tapered segment with a constant taper angle along a length thereof.60. The guidewire of claim 68 , ...

Delivering and/or receiving fluids

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

BIO-DIAGNOSTIC TESTING SYSTEM AND METHODS

An implantable diagnostic device in accordance with the present disclosure includes a probe assembly that can be implemented in a variety of ways. A few example implementations include: a needle inside which is located a bio-sensor chip (the needle being insertable into a human being); a compact package containing the bio-sensor chip (the compact package configured for placement inside a catheter); or a silicon-based bio-sensor package configured for insertion into a vein. 1. A bio-diagnostic system comprising:a probe assembly configured for insertion into an animate object, the probe assembly comprising:an optical waveguide configured for propagating a light beam; andan optical resonator incorporating a capture agent placed upon a binding site that is exposed to a fluid, the optical resonator configured to receive at least a portion of the propagated light beam and generate therefrom, a first resonant wavelength when no binding reaction is present at the binding site, and a second resonant wavelength when a binding reaction is present at the first binding site, the binding reaction modifying a refractive index of the optical resonator.2. The bio-diagnostic system of claim 1 , wherein the probe assembly is at least one of: a) a needle comprising a first bio-sensor chip that includes the optical waveguide and the first optical resonator claim 1 , b) a catheter comprising a second bio-sensor chip that includes the optical waveguide and the first optical resonator claim 1 , or c) a third bio-sensor chip configured for insertion into the vein claim 1 , the third bio-sensor chip comprising the optical waveguide and the first optical resonator.3. The bio-diagnostic system of claim 2 , wherein at least one of the needle or the catheter is a part of an intravenous (IV) apparatus.4. The bio-diagnostic system of claim 2 , wherein the needle has a sub-mm diameter.5. The bio-diagnostic system of claim 4 , wherein the fluid is one of: blood claim 4 , lymphatic fluid claim 4 , ...

DEVICE FOR SENSING A TARGET CHEMICAL AND METHOD OF ITS MAKING

The present invention relates to a device for sensing a target chemical. The device includes a flexible, non-planar substrate; a printed, solid-state sensing element comprising a chemical sensing material which produces an electrical signal upon interaction with the target chemical; a first printed electrode comprising a first conductive composition; and a second electrode comprising a second conductive composition. The first and second electrodes are electrically isolated from one another, and one or both of the first and second electrodes is in electrical contact with said sensing element. The first and second electrodes and the sensing element collectively form an electrochemical sensor which is coupled to the flexible, non-planar substrate. Medical devices comprising the device of the present invention and methods of making a device for sensing a target chemical are also disclosed. 1. A device for sensing a target chemical comprising:a flexible, non-planar substrate;a printed, solid-state sensing element comprising a chemical sensing material which produces an electrical signal upon interaction with the target chemical;a first printed electrode comprising a first conductive composition; anda second electrode comprising a second conductive composition, wherein said first and second electrodes are electrically isolated from one another, and one or both of the first and second electrodes is in electrical contact with said sensing element, wherein said first and second electrodes and said sensing element collectively form an electrochemical sensor, which is coupled to said flexible, non-planar substrate.2. The device according to claim 1 , wherein the first printed electrode is in electrical contact with said sensing element.3. The device according to claim 1 , wherein both the first and second electrodes are in electrical contact with said sensing element.4. The device according to claim 1 , wherein the second electrode is printed onto the substrate.5. The device ...

Catheter balloon methods and apparatus employing sensing elements

An apparatus for medical diagnosis and/or treatment is provides. The apparatus includes a flexible substrate forming an inflatable body and a plurality of sensing elements disposed on the flexible substrate. The plurality of sensing elements are disposed about the inflatable body such that the sensing elements are disposed at areas of minimal curvature of the inflatable body in a deflated state.

SURGICAL TISSUE MONITORING SYSTEM

A tissue monitoring system includes an introducer having an inflatable section and a plurality of electrodes disposed thereon. The electrodes are alternatively connected to an electrode contact system which includes at least one signal line and at least one measurement line for taking readings about a circumferential segment of tissue encompassed by the electrodes. 1. A method of monitoring tissue comprising:placing an introducer having an inflatable section and a plurality of electrodes disposed about the inflatable section adjacent to a section of tissue;distending the first inflatable section of the introducer;imposing an electrical signal on the tissue using a subset of the plurality of electrodes selected for an electrode contact system;measuring a resulting potential with the subset of the plurality of electrodes of the electrode contact system; andshifting the electrode contact system to alternate placement of the electrode contact system within the tissue.2. The method of claim 1 , wherein the step of shifting the electrode contact system includes electronically shifting each contact of the electrode contact system to encompass a different subset of the plurality of electrodes.3. The method of claim 2 , wherein electronically shifting each contact includes shifting each contact to an adjacent electrode on the inflatable section of the introducer.4. The method of claim 1 , wherein the introducer further includes a shaft extending through the introducer claim 1 , and wherein the step of shifting the electrode contact system includes rotating the shaft to shift the electrode contact system clockwise or counterclockwise around a circumferential segment of the tissue.5. The method of claim 1 , further comprising repeating the step of shifting the electrode contact system until an entire circumference of the tissue is characterized.6. The method of claim 1 , wherein the step of imposing an electrical signal includes attaching two electrodes of the subset of the ...

NON-INVASIVE MEDICAL CONDITION MONITORING APPARATUS

Embodiments of the present invention may provide a detector device including a communication interface to couple the detection device to an external antenna device. The detector device may detect medical condition(s) by performing a reference scan and a subsequent target scan. The target scan may be compared to the reference scan, and deviations from the reference scan may indicate the presence of the medical condition(s). According to embodiments of the present invention, the detection device may continuously monitor for medical condition(s) by performing an initial reference scan and subsequent target scans. Each target scan may be compared to the reference scan, and deviations from the reference scan may indicate the presence of the medical condition(s) or a change in the medical condition(s). 1. A detector device comprising:transmitting circuitry to generate micropower impulse radar signals and transmit a first signal to perform a reference scan and a second signal to perform a target scan;receiving circuitry to receive reflection data in response the reference scan and the target scan; anda processor to compare the reflection data of the reference scan and the reflection data of the target scan to determine if a medical condition is present.2. The device of claim 1 , wherein:the transmitting circuitry transmits the first and second signals to an antenna that transmits electromagnetic waves in response to the signals; andthe receiving circuitry receives reflection data associated with the first and second signals from the antenna.3. The device of claim 1 , wherein the detector device continuously monitors for medical conditions by sending an initial reference scan and subsequent target scans.4. The device of claim 1 , wherein the medical condition is a pneumothorax.5. The device of claim 1 , wherein the reference scan is performed when the medical condition is not present.6. The device of claim 1 , wherein the processor uses envelope detection with a synthetic ...

MAPPING SYSTEM AND METHOD FOR MEDICAL PROCEDURES

A system and method for mapping interluminal structures includes an elongated flexible instrument (). An optical shape sensing device () is disposed within the flexible instrument and is configured to determine a shape of the flexible instrument relative to a reference. The shape sensing device is configured to collect information based on its configuration to map an interluminal structure during a procedure. An imaging enabled ablation device () is mounted at or near a distal end portion of the flexible instrument. 1. A system for mapping interluminal structures , comprising:{'b': '102', 'an elongated flexible instrument ();'}{'b': 152', '154, 'an optical shape sensing device (, ) disposed within the flexible instrument and configured to determine a shape of the flexible instrument relative to a reference, the shape sensing device configured to collect information based on its configuration to map an interluminal structure during a procedure; and'}{'b': '117', 'an imaging enabled ablation device () mounted at or near a distal end portion of the flexible instrument.'}2152154154. The system as recited in claim 1 , wherein the optical shape sensing device includes an optical fiber () having at least one of Fiber Bragg Gratings (FBGs) () and a Rayleigh scatter interrogation setup () for sensing strain in the fiber.3152154. The system as recited in claim 1 , wherein the optical shape sensing device includes an area of higher sensitivity by including an area with a higher number of optical fibers () having optical strain sensors ().4. The system as recited in claim 1 , wherein the optical shape sensing device includes one of a spiral shape claim 1 , a ring shape and a loop shape.5. The system as recited in claim 1 , wherein the reference includes one of a position on the flexible instrument and an anatomical reference.6102. The system as recited in claim 1 , wherein the flexible instrument () includes one of a catheter and an endoscope.7. A system for mapping ...

MEDICAL DEVICE WITH SLOTTED MEMORY METAL TUBE

A series of medical instruments can be made with the use of shape memory tube with a transformation temperature that is above or below ambient temperature. In the first case, the material behaves with the shape memory effect and in the second case the behavior is superelastic. The wall of the tube has been provided with a plurality of slots in specific places, often near or at the distal end of the instrument, and in specific arrangements which allow local variations in diameter, shape, and/or length. These variations can either be caused by the memory effect during temperature change or by superelastic behavior during change of the mechanical influences on the memory metal by the surrounding material. 1. A medical instrument comprising:at least one memory metal tube programmed for memory effect or superelasticity and having in at least one section thereof a plurality of slots such that the slotted section is capable of expansion and contraction, said memory metal tube having an expandable section that is substantially filled by an elastically deformable polymer, which upon expansion in a tubular cavity plugs the cavity; anda delivery tube that surrounds at least the slotted section of the memory metal tube during delivery and which is partially removed from surrounding the slotted section of the memory metal tube by a relative longitudinal movement between the respective tubes.2. The instrument of being a retrieval basket for retrieving particles to be removed from the human body.3. The instrument of being a dilator to enlarge the diameter of collapsed or obstructed ducts claim 1 , veins claim 1 , arteries or other cavities in the human body.4. The instrument of being a reaming tool to cut parts off the wall of a cavity by rotational movement around the longitudinal axis of the instrument.5. The instrument of being an expansion tool that is expandable at a distal end to enlarge a body cavity.6. The instrument of wherein the slots in the memory metal tube extend to ...

PRESSURE SENSING SYSTEM AND METHOD

A device for detecting rhinitis in a human subject includes an inflatable member that, in a first state, is configured to be introducible into the nasal cavity of the human subject; an expansion member configured to expand the inflatable member to an expanded, second state within the nasal cavity such that the inflatable member abuts against the tissue of the nasal cavity, and a pressure sensing member configured to measure a pressure exerted on the inflatable member by the tissue of the nasal cavity. A system for detecting rhinitis and methods for analyzing tissue response pressure, detecting rhinitis, predicting the efficacy of a planned rhinitis treatment and evaluating the efficacy of a previous rhinitis treatment are provided. 1. A method for detecting rhinitis , comprising:introducing an inflatable member into a nasal cavity of a human subject;expanding the inflatable member within the nasal cavity such that the inflatable member abuts against a tissue of the nasal cavity;measuring a pressure exerted on the inflatable member by the tissue of the nasal cavity over a period of time to create a measured pressure curve; andanalyzing the measured pressure curve to detect rhinitis.2. A method for evaluating the efficacy of a previously performed rhinitis treatment , comprising:introducing an inflatable member into a nasal cavity of a human subject;expanding the inflatable member within the nasal cavity such that the inflatable member abuts against a tissue of the nasal cavity;measuring a pressure exerted on the inflatable member by the tissue of the nasal cavity over a period of time to create a measured pressure curve; andanalyzing the measured pressure curve to evaluate the efficacy of the previous rhinitis treatment.3. A method for predicting the efficacy of a rhinitis treatment , comprising:introducing an inflatable member into a nasal cavity of a human subject;expanding the inflatable member within the nasal cavity such that the inflatable member abuts against ...

Device and method for measuring pressure exerted on a surface

Provided are methods and devices for measuring pressure exerted against a surface. In an aspect, the surface corresponds to the urethra and the device measures the pressure exerted against the urethra. Methods include treatment of a patient suffering urinary stress incontinence. A pressure sensor system is used to determine, pre-surgically, the minimum pressure required to alleviate incontinence. During surgery, the pressure sensor system is employed to ensure the surgical intervention provides a corresponding minimum pressure that was clinically identified. In this manner, the surgical intervention is precisely monitored and measured to insure the appropriate pressure is exerted on the urethra to alleviate stress incontinence, thereby improving surgical outcome and decreasing post-operative complications.

System And Method For Treating Heart Tissue

Some embodiments of a system or method for treating heart tissue can include a control system and catheter device operated in a manner to intermittently occlude a heart vessel for controlled periods of time that provide redistribution of blood flow. In particular embodiments, the system and methods may be configured to monitor at least one input signal detected at a coronary sinus and thereby execute a process for determining a satisfactory time period for the occlusion of the coronary sinus. In further embodiments, after the occlusion of the coronary sinus is released, the control system can be configured to select the duration of the release phase before the starting the next occlusion cycle.

Systems and methods for making and using medical ablation systems having mapping catheters with improved anchoring ability

A mapping catheter includes an elongated body for inserting into patient vasculature. A distal end of the elongated body includes a distal portion that includes a plurality of electrodes, a proximal portion disposed proximal to the distal portion, and a reduced-dimension portion disposed between the proximal and distal portions. The distal end is formed, at least in part, from a memory shape material that bends into a preformed shape upon release from a confined space. The preformed shape includes a first loop formed, at least in part, by the distal portion. The first loop is transverse to a longitudinal axis of the proximal portion. The reduced-dimension portion is configured and arranged to bend such that the reduced-dimension section advances distally through the first loop when the first loop is held in a fixed position and a force is applied distally along the longitudinal axis of the proximal portion.

SENSOR GUIDE WIRE

The present invention relates to a sensor guide wire () for intravascular measurements of at least one variable in a living body, which sensor guide wire () has a proximal region (), a distal sensor region () and a tip region (). The sensor guide wire () comprises, a sensor element arranged in said sensor region (), a tip region core wire () having a longitudinal axis () and extending essentially along said tip region (), and a coil () arranged in said tip region (). The coil () at least partly encloses said tip region core wire (), and a distal tip joint () is arranged at a distal end () of said sensor guide wire () for attaching said coil () to said tip region core wire (). A major part of said tip region core wire () has a circular cross-section in a plane perpendicular to said longitudinal axis (). 1112341. Sensor guide wire () for intravascular measurements of at least one variable in a living body , which sensor guide wire () has a proximal region () , a distal sensor region () and a tip region () , the sensor guide wire () comprises:{'b': '3', 'a sensor element arranged in said sensor region (),'}{'b': 5', '6', '4, 'a tip region core wire () having a longitudinal axis () and extending essentially along said tip region (),'}{'b': 7', '4, 'a coil () arranged in said tip region (),'}{'b': 7', '4', '8', '9', '1', '7', '5', '5', '6, 'which coil () at least partly encloses said tip region core wire (), wherein a distal tip joint () is arranged at a distal end () of said sensor guide wire () for attaching said coil () to said tip region core wire (), characterized in that a major part of said tip region core wire () has a circular cross-section in a plane perpendicular to said longitudinal axis ().'}21564. Sensor guide wire () according to claim 1 , wherein said tip region core wire () has a circular cross-section in a plane perpendicular to said longitudinal axis () in the entire tip region ().315. Sensor guide wire () according to claim 1 , wherein said major part ...

Scalable network apparatus for content based switching or validation acceleration

A network apparatus is provided that may include one or more security accelerators. The network apparatus also includes a plurality of network units cascaded together. According to one embodiment, the plurality of network units comprise a plurality of content based message directors, each to route or direct received messages to one of a plurality of application servers based upon the application data in the message. According to another embodiment, the plurality of network units comprise a plurality of validation accelerators, each validation accelerator to validate at least a portion of a message before outputting the message.

Enhanced medical device for use in bodily cavities, for example an atrium

Systems, methods, and devices allow intravascular or percutaneous mapping, orientation and/or ablation, in bodily cavities or lumens. A device includes elongate members, moveable between an unexpanded configuration and an expanded or fanned configuration. The elongate members form a stack in the unexpanded configuration to fit through a catheter sheath. The elongate members follow respective arcuate or curvilinear paths as advanced from the sheath into the bent or coiled stack configuration, adopting volute, scroll or rho shapes, and may be nested. The elongated members are fanned or radially spaced circumferentially with respect to one another into the expanded or fanned configuration. Transducer elements carried by elongate members sense various physiological characteristics of or proximate tissue, and/or may apply energy to or proximate tissue. The elongate members are rotatable in groups or as a group in the expanded configuration. The device is retractable.

SINGLE INJECTION METHODS FOR OBTAINING CONDUCTANCE MEASUREMENTS WITHIN LUMINAL ORGANS USING IMPEDANCE DEVICES

Single injection methods for obtaining conductance measurements within luminal organs using impedance devices. In at least one method embodiment, the method is performed by introducing at least part of an impedance device into a mammalian luminal organ, the impedance device comprising an elongated body and a detector positioned along the elongated body, obtaining conductance measurements indicative of a fluid native to the mammalian luminal organ and indicative of a fluid injection while the detector is present within and outside of the lumen of the outer sheath, and calculating a size parameter of the mammalian luminal organ based in part upon some of the obtained conductance measurements. 1. A method for obtaining one or more conductance measurements using an impedance device , the method comprising the steps of:introducing at least part of an impedance device into a mammalian luminal organ, the impedance device comprising an elongated body and a detector positioned along the elongated body;obtaining a first conductance measurement using the detector while the detector is surrounded by an outer sheath surrounding at least part of the impedance device, the first conductance measurement indicative of a fluid native to the mammalian luminal organ present within a lumen of the outer sheath;obtaining a second conductance measurement using the detector while the detector is surrounded by the outer sheath, the second conductance measurement indicative of a first injection of a first solution of a first compound through the lumen of the outer sheath;moving the impedance device and/or the outer sheath relative to one another so that the outer sheath no longer surrounds the detector;obtaining a third conductance measurement using the detector, the third conductance measurement indicative of the fluid native to the mammalian luminal organ;obtaining a fourth conductance measurement using the detector, the fourth conductance measurement indicative of a second injection of the ...

Method for producing an electrophysiological map of the heart

Methods and systems for producing an electrophysiological map of a heart of a patient are disclosed. An example method may include determining a target location and an orientation of a catheter tip, confirming that the tip is located at the target location, measuring the heart parameter value at each of the target locations, and superimposing a plurality of representations of the heart parameter value. Confirmation that the tip of the catheter is located at a target location can be accomplished by comparing the current location of the tip with the target location, a corresponding heart parameter value being measured at each of the target locations by a heart parameter sensor, and the representations of the heart parameter value being superimposed on an image of the heart at the target location to produce the electrophysiological map. 1. A method for producing an electrophysiological map of a heart , the method comprising:reconstructing a three-dimensional model of the heart from a plurality of two-dimensional images, wherein a coordinate system of the three-dimensional model is registered with a medical positioning system coordinate system;for each of a plurality of target points within the heart, determining a target point location associated with the three-dimensional model and a respective target probe orientation at which a heart parameter value is to be measured;for each target point, confirming that a probe of a catheter is located at the target point location by comparing a currently detected location of the probe with the respective target point location;for each target point, confirming that the probe is oriented at the probe orientation by comparing the currently detected orientation of the probe with the respective target probe orientation;for each target point, measuring the heart parameter value with a heart parameter sensor; andproducing the electrophysiological map.2. The method according to claim 1 , wherein the coordinate system of the three- ...

System, method and apparatus for optical imaging of luminal organs, and for centering within and contacting a luminal organ

Exemplary apparatus and method can be provided for obtaining data for at least one portion within at least one luminal or hollow sample. It is possible, e.g., using a first optical arrangement, to transceive at least one electromagnetic radiation to and from the portion(s). Further, it is possible, e.g., to actuate an expandable second basket arrangement so as to position the first arrangement at a predetermined location within the luminal or hollow sample(s). The second arrangement can have at least one prong or strip that has a flat shape on at least one side thereof.

Interface Devices, Systems, and Methods for Use With Intravascular Pressure Monitoring Devices

Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to provide FFR measurements in a small, compact device that integrates with existing proximal and distal pressure measurement systems and does not require a separate power source. 1. An interface for intravascular pressure sensing devices , comprising:a distal input configured to receive a distal pressure signal from a distal pressure sensing device;a distal output configured to output the distal pressure signal to a hemodynamic system in a format useable by the hemodynamic system;a proximal input configured to receive a proximal pressure signal from a proximal pressure sensing device;a proximal output configured to output the proximal pressure signal to the hemodynamic system in a format useable by the hemodynamic system;a processor coupled to the distal input, distal output, proximal input, and proximal output, the processor configured to calculate a pressure differential between the distal pressure and the proximal pressure based on the received distal pressure signal and the received proximal pressure signal; anda display in communication with the processor and configured to display the pressure differential calculated by the processor.2. The interface of claim 1 , wherein the distal input claim 1 , distal output claim 1 , proximal input claim 1 , proximal output claim 1 , processor claim 1 , and display are secured to a housing.3. The interface of claim 2 , wherein the housing has a width between 5 cm and 25 cm claim 2 , a height between 5 cm and 25 cm claim 2 , and a depth between 1 cm and 10 cm.4. The interface of claim 3 , wherein the distal pressure sensing device is a pressure-sensing guidewire.5. The interface of claim 4 , wherein the proximal pressure sensing device is a pressure-sensing catheter ...

System to diagnose the function of intrinsic sphincters

A system treats at least one of the urethral and anal sphincters. A muscle contraction device is located on at least one of the urethral and anal sphincters. A controller is connected to the muscle contraction device and operative to transmit control signals to the muscle contraction device located on at least one of the urethral and anal sphincters to contract the muscle during an inspiratory phase of respiration.

Systems and Methods for Positioning a Catheter

A method for displaying a position of a medical device, such as a catheter, during insertion thereof into a patient. In one example embodiment, the method includes obtaining a first set of detected position data relating to a location marker, such as a permanent magnet, then determining a possible first position thereof. A first confidence level relating to a match between the first set of detected position data and a first set of predicted position data is assigned. A determination is made whether the first confidence level meets or exceeds a first threshold. If the first confidence level meets or exceeds the first threshold, a determination is then made whether the first position of the location marker is within a first detection zone. If the first position of the location marker is within the first detection zone, the first position of the location marker is displayed. 1. A method of depicting a position of a catheter that is within a patient , the method comprising:providing a device including a permanent magnet;inserting the device into a blood vessel;positioning a detector having a first detection zone and a second detection zone such that at least the first detection zone includes a portion of the blood vessel into which the device is inserted;obtaining, via the detector, first measurements of the magnetic field produced by the permanent magnet;determining a first confidence level regarding a first position of the permanent magnet based on the first measurements;displaying an initial representative image of the permanent magnet if the first position is within the first detection zone and the confidence level is above a first threshold value;obtaining, via the detector, second measurements of the magnetic field produced by the permanent magnet;determining a second confidence level regarding a second position of the permanent magnet based on the second measurements; anddisplaying a subsequent representative image of the permanent magnet if the second position ...

Catheter locator apparatus and method of use

This invention relates to a method of catheter and radiating coil location in a human body and in particular to the determination over time of the location of the tip of a catheter as it is inserted and during its use in the body. In particular when a radiating coil is used in conjunction with a catheter, a coil locating device can be used to determine the distance the coil is from the device and hence its depth in the body of a patient. To assist a clinician using the coil-locating device, a display is provided that shows both a reference image of a part or portion of a body (non-subject body) and an image of the coil located on the display with reference to the reference image. This is achieved by locating the coil-locating device on or over a predetermined landmark on the patient's body. The coil and its associated signal wires can be incorporated into a stylet, guide wire or a catheter. The coil locating device has a preferable triangular shape in plan view that allows its uppermost apex to be orientated towards the head of the patient and for an axis of the device to be aligned with the mid sagittal plane of the patient. Preferable landmarks on a human body include the xiphoid sternal junction and the caudal/mid sagittal aspect of the jugular sternal notch.

Guidewire with internal pressure sensor

The present document describes a pressure guidewire comprising: a shaft tube with a proximal section; a middle section extending from the proximal section of the shaft tube, the middle section having greater flexibility than the proximal section; an inner hypotube installed substantially within the middle section for optimal mechanical properties; a pressure sensor with a communication means routed through the middle section and the proximal section; and a sensor housing for receiving the pressure sensor. There are also described methods for joining the inner hypotube to the shaft tube.

INTERFACE UNIT, MEASUREMENT SYSTEM AND A METHOD IN AN INTERFACE UNIT

The present invention relates to an extracorporeale interface unit (), for an intravascular measurement system for measuring a physiological, or other, variable in a living body, being adapted to generate a sensor signal in response of said variable. The interface unit () comprises a sensor interface circuitry () adapted to interface a sensor wire configured to be inserted into the living body and provided with one or many sensor element(s) at its distal region. The sensor interface circuitry () further comprises a measurement unit () adapted to generate the measured data of the variable as a sensor signal. The sensor interface circuitry () comprises two current source units (CSU, CSU) adapted to energize the sensor element(s) via at least two connection points (CP, CP, . . . CPn), and a switching unit (), wherein the switching unit () is adapted to alternately switch connection between the current source units (CSU, CSU) and at least two of the connection points (CP, CP, . . . CPn), using a preset switching frequency having essentially the same connection time period (T) for each connection. The measurement unit () is adapted to determine a sensor variable value (V) related to the variable at two of the connection points (CP, CP, . . . CPn). The present invention further relates to a measurement system () comprising said extracorporeale interface unit () and a method in said interface unit. 28. The interface unit () according to claim 1 , wherein said sensor signal is related to the average value of sensor variable values (V) from at least two connection time periods (T).3812. The interface unit () according to claim 1 , wherein said sensor variable value (V) is the absolute value of the voltage difference between the connected connection points (CP claim 1 , CP claim 1 , . . . CPn) during one connection time period (T).4812. The interface unit () according to claim 1 , wherein the variable is determined as a value related to the sensor variable value (V) and the ...

SURGICAL CATHETER HAVING SIDE EXITING MEDICAL INSTRUMENT AND RELATED SYSTEMS AND METHODS FOR FOUR DIMENSIONAL SOFT TISSUE NAVIGATION

A surgical instrument navigation system is provided that visually simulates a virtual volumetric scene of a body cavity of a patient from a point of view of a surgical instrument residing in the cavity of the patient, wherein the surgical instrument, as provided, may be a steerable surgical catheter with a biopsy device and/or a surgical catheter with a side-exiting medical instrument, among others. Additionally, systems, methods and devices are provided for forming a respiratory-gated point cloud of a patient's respiratory system and for placing a localization element in an organ of a patient. 1. A surgical catheter for navigated surgery , comprising:an elongate flexible shaft having a proximal end portion, an opposite distal end portion, a longitudinal axis, a side exit in the distal end portion, and an outer wall extending from the proximal end portion to the distal end portion;a handle attached to the proximal end portion;an electromagnetic localization element at the distal end portion; anda medical instrument housed within the elongate flexible shaft that is extendable along a path from a position within the outer wall and through the side exit to an extended position outside the outer wall, the medical instrument being disposed at an angle of at least 10 degrees relative to the longitudinal axis at the side exit when in the extended position, wherein the position of the medical instrument along the path can be calibrated to the location of the electromagnetic localization element and displayed by a surgical instrument navigation system.2. The surgical catheter of wherein the elongate flexible shaft comprises a steering mechanism comprising a steering actuator at the proximate end portion and a pull wire connected to the steering actuator wherein the distal end portion may be moved relative to the proximal end portion by manipulating the steering actuator to apply a tension to the pull wire.3. The surgical catheter of wherein an arc of at least 20 degrees may ...

STEERABLE SURGICAL CATHETER HAVING BIOPSY DEVICES AND RELATED SYSTEMS AND METHODS FOR FOUR DIMENSIONAL SOFT TISSUE NAVIGATION

A surgical instrument navigation system is provided that visually simulates a virtual volumetric scene of a body cavity of a patient from a point of view of a surgical instrument residing in the cavity of the patient, wherein the surgical instrument, as provided, may be a steerable surgical catheter with a biopsy device and/or a surgical catheter with a side-exiting medical instrument, among others. Additionally, systems, methods and devices are provided for forming a respiratory-gated point cloud of a patient's respiratory system and for placing a localization element in an organ of a patient. 1. A surgical catheter , comprising:an elongate flexible shaft having a proximal end portion, an opposite distal end portion, a longitudinal axis extending from the proximal end portion to the distal end portion and an outer wall extending from the proximal end portion to the distal end portion;a handle attached to the proximal end portion;a biopsy device at the distal end portion;an actuation wire extending from the proximal end portion to the distal end portion to operate the biopsy device; anda steering mechanism comprising a steering actuator at the proximal end portion and a pull wire connected to the steering actuator wherein the distal end portion may be moved relative to the proximal end portion by manipulating the steering actuator to apply a tension to the pull wire.2. The surgical catheter of wherein an arc of at least 20 degrees may be introduced into the elongate flexible shaft by manipulation of the steering actuator.3. The surgical catheter of wherein an arc of at least 120 degrees may be introduced into the elongate flexible shaft by manipulation of the steering actuator.4. The surgical catheter of wherein manipulation of the steering actuator to introduce an arc of at least 120 degrees into the elongate flexible shaft causes the distal end portion to move such that a distance of no more than 1 inch separates two regions of the elongate flexible shaft located ...

Robotic catheter system

A robotic catheter system includes a controller with a master input device. An instrument driver is in communication with the controller and has a guide instrument interface including a plurality of guide instrument drive elements responsive to control signals generated, at least in part, by the master input device. An elongate guide instrument has a base, distal end, and a working lumen, wherein the guide instrument base is operatively coupled to the guide instrument interface. The guide instrument includes a plurality of guide instrument control elements operatively coupled to respective guide drive elements and secured to the distal end of the guide instrument. The guide instrument control elements are axially moveable relative to the guide instrument such that movement of the guide instrument distal end may be controlled by the master input device.

Biomarker Sampling in the Context of Neuromodulation Devices, Systems, and Methods

Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to biomarker sampling in the context of neuromodulation devices, systems, and methods. Some embodiments, for example, are directed to catheters, catheter systems, and methods for sampling biomarkers that change in response to neuromodulation. A system can include, for example, an elongated shaft and a neuromodulation and sampling assembly having a neuromodulation and a sampling element. 1. A system , comprising:a neuromodulation element configured to modulate nerves at or otherwise proximate to a renal artery of a patient;an elongated shaft having a first portion configured to be intravascularly positioned while the neuromodulation element modulates the nerves, and a second portion proximal to the first portion, the second portion configured to be extracorporeally positioned while the neuromodulation element modulates the nerves;an occlusion member extending around a segment of the first portion;a sampling port distal to the segment of the first portion;a sampling lumen extending from the sampling port toward the second portion;an inflation opening within the occlusion member; andan inflation lumen extending from the inflation opening toward the second portion.2. The system of claim 1 , further comprising an analyzer configured to analyze a biological sample from the patient for a biological parameter that changes in response to modulating the nerves.3. The system of wherein:the analyzer is operably connected to the second portion; andthe sampling lumen extends from the sampling port along the shaft to the analyzer.4. The system of claim 2 , further comprising a handle coupled to the second portion claim 2 , wherein the analyzer is carried by the handle.5. The system of wherein the analyzer includes an indicator configured to indicate a status of the biological parameter claim 2 , a ...

System and methods for locating and ablating arrhythomogenic tissues

The disclosure relates to a variety of systems and methods for sensing electrical events about a selected annulus region of the heart and for treating tissue in the selected annulus region. Wherein the system includes a first catheter that has an expandable member, an ablation element, and a lumen configured to allow a second catheter therethrough. The second catheter includes a distal section in a ring shape and a plurality of electrodes coupled around the ring. Optionally a second lumen can be included through the first catheter that allows for contrast media to be delivered to the distal end of the system. 120-. (canceled)21. A system for sensing electrical events about a selected intrabody annulus region and for treating tissue in the selected annulus region , comprising:a first catheter and a second catheter; a first handle assembly;', 'a first shaft having a first proximal end coupled to the first handle assembly, and a first distal end, the first shaft extending along a first axis;', 'a first lumen extending entirely through the first distal end of the first shaft along the first axis;', 'a second lumen extending entirely through the first distal end of the first shaft along the first axis;', 'an ablation element provided adjacent the first distal end of the first shaft;', 'an expandable member adjacent the first distal end; and', 'wherein the first lumen is adapted to receive the second catheter therethrough;, 'the first catheter comprising a second handle assembly;', 'a second shaft having a second proximal end coupled to the second handle assembly, and a second distal end, the second shaft of the second catheter extending along a second axis; and', 'a distal ring provided at the second distal end of the second shaft of the second catheter and oriented substantially perpendicular to the second axis of the second shaft of the second catheter, the distal ring having a plurality of discrete electrodes positioned about the distal ring of the second catheter., ' ...

DEVICES, SYSTEMS, AND METHODS FOR OCCLUDING A DEFECT

A method of occluding a defect in a patient is provided. The method includes inserting a placement member, such as a wire guide, into a defect; advancing the placement member to a desired location; inserting the placement member into a lumen in an occluding member, such as a plug or a graft; and advancing the occluding member to the desired location by inserting the placement member into a lumen in a pusher member and pushing the occluding member with the pusher member until the occluding member reaches the desired location. Medical devices and systems for occluding defects are also provided. 130-. (canceled)31. A method of occluding a defect , comprising:inserting a placement member at least partially into the defect;advancing the placement member to a desired location;inserting the placement member into the occluding member;placing a pusher member against the occluding member; andadvancing the occluding member over the placement member to the desired location by pushing the occluding member with the pusher member until the occluding member reaches the desired location, whereby the defect is occluded.32. The method of claim 31 , wherein the placement member comprises a wire guide.33. The method of claim 31 , wherein the placement member comprises a tubular device.34. The method of claim 33 , further comprising injecting a contrast solution into the defect using the hollow tubular device.35. The method of claim 31 , wherein the placement member comprises an endoscope.36. The method of claim 31 , wherein the occluding member comprises a plug.37. The method of claim 36 , wherein the plug comprises an extracellular matrix material.38. The method of claim 37 , further comprising advancing the plug to the desired location prior to rehydration of the plug.39. The method of claim 31 , wherein the occluding member comprising a first lumen extending throughout its length.40. The method of claim 31 , further comprising anchoring the occluding member within the defect.41. The ...

STEERABLE GUIDE WIRE WITH PRESSURE SENSOR AND METHODS OF USE

A high performance guide wire with a pressure sensor for measuring blood pressure, may utilize a single electrical lead connected to the guide wire. An integrated circuit, powered by the single electrical connection on the guide wire, may interface with the pressure sensor, and may convert pressure information to an encoded signal. The encoded signal may be detectable in the electrical circuit, and can be used to display a pressure waveform as detected by the pressure sensor. For example, when utilized for percutaneous coronary interventions, such a guide wire can provide high quality blood pressure measurements (e.g., for fractional flow reserve), while also possessing excellent steerability and handling characteristics for navigating tortuous anatomy. 1. An elongate intravascular guide wire , comprising:an electrically conductive core wire connected to a sensor housing;an insulating layer covering at least part of the core wire;a pressure sensor and an integrated circuit located within the sensor housing;at least one return electrode connected to the integrated circuit, wherein the integrated circuit, pressure sensor, and return electrode are electrically connected to form part of a primary electrical circuit; andan electrical connector disposed on a proximal portion of the core wire, configured to penetrate the insulating layer, and electrically connected to the core wire, said core wire being configured to deliver electrical power to the integrated circuit from the connector, and said integrated circuit being configured to transmit electrical information.2. The guide wire of claim 1 , wherein the integrated circuit is configured to convert transduced pressure information from the pressure sensor to digital information claim 1 , and convey the digital information to the primary electrical circuit.3. (canceled)4. (canceled)5. The guide wire of claim 1 , further comprising a distal coil extending from the sensor housing claim 1 , wherein the distal coil forms at ...

Mapping probe assembly with skived tube body frame

An embodiment of a mapping probe assembly includes a body frame with a lumen therein. The body frame includes a catheter shaft region, a loop section and a transition region between the catheter shaft region and a loop section. A plurality of mapping electrodes are attached around the loop section. Electrical conductors extend through the lumen of the body frame to the mapping electrodes. In some embodiments, the loop section is skived, where a portion of the body frame is removed toward the interior of the loop section. The loop section has a generally planar loop, and further has a loop center. In some embodiments, the catheter shaft has an alignment generally perpendicular to the loop section where the alignment of the catheter shaft is along a line that intersects the planar loop proximate to the loop center.

MINIMALLY INVASIVE DETERMINATION OF COLLATERAL VENTILATION IN LUNGS

Minimally invasive methods, systems and devices are provided for qualitatively and quantitatively assessing collateral ventilation in the lungs. In particular, collateral ventilation of a target compartment within a lung of a patient is assessed by advancement of a catheter through the tracheobronchial tree to a feeding bronchus of the target compartment. The feeding bronchus is occluded by the catheter and a variety of measurements are taken with the use of the catheter in a manner which is of low risk to the patient. Examples of such measurements include but are not limited to flow rate, volume and pressure. These measurements are used to determine the presence of collateral ventilation and to quantify such collateral ventilation. 1. A method for determining the function or malfunction of an endobronchial prosthesis positioned within a lung passageway of a patient , said method comprising:occluding the lung passageway proximally of the endobronchial prosthesis;allowing the patient to breathe air without any markers; andmeasuring air flow or accumulation from the lung passageway over time wherein said measurement is correlative to the function or malfunction of the endobronchial prosthesis.2. A system for detecting collateral ventilation into a lung compartment in a patient , said system comprising:a catheter adapted to be introduced transtracheally to a bronchus leading to a target lung compartment;an occlusion member on a distal region of the catheter, said occlusion member being adapted to selectively occlude the bronchus; anda flow measurement sensor on the catheter to detect flow of air from the isolated compartment as the patient exhales.3. A system for detecting collateral ventilation into a lung compartment in a patient , said system comprising:a catheter adapted to be introduced transtracheally to a bronchus leading to a target lung compartment;an occlusion member or a distal region of the catheter, said occlusion member being adapted to selectively ...

GUIDE FOR PLACEMENT OF CATHETER INTO BRAIN AND A METHOD OF UTILIZING THE SAME

The subject matter discloses an apparatus for detecting an environment within a body comprising: an apparatus comprising a stylet and a catheter capable of being inserted into the body; a bio-sensing module for detecting a predefined material within the body, upon insertion of the stylet and catheter with close proximity to the predefined material 1. An apparatus for detecting an environment within a body comprising:an apparatus comprising a stylet and a catheter capable of being inserted into the body;a bio-sensing module for detecting a predefined material within the body, upon insertion of the stylet and catheter with close proximity to the predefined material.2. The apparatus of wherein the bio-sensing module further indicates the presence of the predefined material.3. The apparatus of wherein the indication is provided using electrical connecting element.4. The apparatus of wherein the predefined material is beta-transferrin.5. The apparatus of wherein at least a portion of the bio-sensing module is located within the stylet.6. The apparatus of wherein the bio-sensing module comprises a biosensor claim 1 , transmitter and an indication unit.7. The apparatus of wherein the bio-sensing module is located in a cavity within the stylet.8. The apparatus of claim 7 , wherein the stylet further comprises one or more apertures for allowing fluid containing the predefined material to enter the stylet cavity.9. The apparatus of wherein the predefined material contacts and activates the bio-sensing module.10. The apparatus of wherein at least a portion of the biosensor is located outside surface of the stylet.11. A method of inserting a catheter or trocar into a body comprising:a. inserting an apparatus comprising a stylet and catheter into the body;b. detecting a predefined material by a biosensor connected to the apparatus upon close proximity of the apparatus to the predefined material.12. The method according to claims 11 , further comprises a step of transmitting data ...

CARDIAC MAPPING CATHETER

A multi electrode catheter for non contact mapping of the heart having independent articulation and deployment features. 118-. (canceled)19. A catheter comprising:an elongate catheter body having a distal end and a proximal end;a proximal handle segment having an articulation control and a deployment control, said proximal handle connected to said proximal end;an intermediate segment connected to said handle segment;a deflectable segment connected to said intermediate segment, said deflectable segment adapted to articulate in a plane through an angle in response to said articulation control;a distal array segment connected to said deflectable segment, said distal array segment including a deployable electrode array that can move from a first retracted position to a second deployed position; said deployable electrode array formed from a flexible printed circuit slit to form splines and rolled about the major axis, the splines of the flexible printed circuit including first regions having a first stiffness and second regions that include one or more stiffener layers and have a second stiffness that is greater than the first stiffness, the stiffness of the first and second regions at least partially determining the shape of the electrode array in the deployed position, said distal array segment has a non-uniform distribution of electrodes in the array with the electrodes being distributed more densely in regions of the deployed array that are more likely to be positioned closely to the endocardium.20. The catheter of wherein:each spline in said deployable electrode array has a non-uniform shape characteristic resulting in control of the shape of the electrode array in the deployed position.21. The catheter of wherein:said distal array segment has a uniform and symmetrical distribution of electrodes in the array.22. The catheter of wherein;said deployable electrode array having bonding apertures at an end of the array adapted for encapsulation to form and retain said ...

Catheter die

A catheter die is provided and includes an elongate body having first and second opposing end portions and an end face at the first one of the first and second opposing end portions. The elongate body defines a cavity within the first end portion with an interior facing surface of the cavity disposed to extend alongside at least a portion of the first end face. At least one or more piezoresistive pressure sensors are operably disposed proximate to the cavity.

SENSOR GUIDE WIRE COMPRISING A POLYMER LAYER

A sensor guide wire for an intravascular measurement of at least one physiological or other variable in a living body may have a proximal region, a distal sensor region, and a tip region. The sensor guide wire may further comprise a sensor clement arranged in the sensor region, and comprising a sensor portion for measuring the variable and to generate a sensor signal in response to the variable. Furthermore, a core wire, having a longitudinal axis A, and comprising at least a tip core wire portion, extends essentially along the tip region of the sensor guide wire. The tip core wire portion may further comprise a distal tip. At least a major part of the tip core wire portion is provided with a polymer layer essentially enclosing the at least major part. The distal tip of the tip core wire portion may further comprise an enlargement. 1. A sensor guide wire for an intravascular measurement of at least one variable in a living body , wherein the sensor guide wire has a proximal region , a distal sensor region and a tip region , the sensor guide wire comprising:a sensor element arranged in the sensor region, the sensor element comprising a sensor portion configured to measure the variable and to generate a sensor signal in response to the variable; anda core wire comprising at least a tip core wire portion extending along the tip region of the sensor guide wire, wherein the tip core wire portion comprises a distal tip; anda polymer layer enclosing at least a major part of the tip core wire portion.2. The sensor guide wire according to claim 1 , wherein the major part of the tip core wire portion is at least 75% of an entire length of the tip core wire portion.3. The sensor guide wire according to claim 1 , wherein the polymer layer covers a distal half of the tip core wire portion.4. The sensor guide wire according to claim 1 , wherein the polymer layer covers the entire tip core wire portion.5. The sensor guide wire according to claim 1 , wherein an entire length of the ...

METHOD OF TREATING BENIGN HYPERTROPHY OF THE PROSTATE

Measurement of a patient's leak point pressure in the bladder can be taken by a processor in communication with a pressure catheter in the bladder. When leakage occurs pressure data points can be recorded. In some embodiments, the peak pressure can be determined based on pressure data points measured during a set time just before receiving a clinician input indicative that leakage has occurred. 1. (canceled)2. A system for measuring leak point pressure in a bladder comprising:a pressure catheter having at least a portion configured for placement in a bladder of a patient;an input device; anda processor in communication with the input device and the pressure catheter, the processor configured to measure pressure associated with the bladder of the patient based on data received from the pressure catheter, wherein in response to receiving a clinician input from the input device the processor is further configured to determine a peak pressure during a set time just before receiving the clinician input.3. The system of claim 2 , wherein the set time comprises five seconds or less.4. The system of claim 2 , wherein the set time comprises three seconds or less.5. The system of claim 2 , wherein the set time comprises two seconds or less.6. The system of claim 2 , wherein the set time comprises one second or less.7. The system of claim 2 , wherein the processor is configured to measure pressure at the rate of about 1000 points per second.8. The system of claim 3 , wherein the processor is configured to measure pressure at the rate of about 1000 points per second.9. The system of claim 2 , further comprising a second pressure catheter having at least a portion configured for placement in a rectum of the patient.10. The system of claim 2 , wherein the input device comprises a button.11. A method for measuring leak point pressure in a bladder comprising:measuring pressure with a processor, the pressure associated with a bladder of a patient based on data received from a ...

CARDIAC CATHETER EMPLOYING CONFORMAL ELECTRONICS FOR MAPPING

An apparatus for medical diagnosis and/or treatment is provided. The apparatus includes a flexible substrate, an intermediate bus disposed on the flexible substrate, and a plurality of sensing elements disposed on the flexible substrate and coupled to the intermediate bus. The plurality of sensing elements and intermediate bus are disposed on the flexible substrate such that the sensing elements are disposed at areas of minimal strain of the flexible substrate. 1. An apparatus for medical diagnosis and/or treatment , the apparatus comprising:a flexible substrate;at least one intermediate bus disposed on the flexible substrate; and 'wherein each sensing element of the plurality of sensing elements is coupled to the at least one intermediate bus.', 'a plurality of sensing elements disposed in a close-packed array proximate to an end of the at least one intermediate bus,'}2. The apparatus of claim 1 , wherein the sensing elements are disposed at areas of minimal bending and/or flexing of the flexible substrate.3. The apparatus of claim 1 , wherein the flexible substrate is an adhesive patch or a bandage.4. The apparatus of claim 1 , wherein a measurement of the plurality of sensing elements provides a measure of an amount of contact between the inflatable body and a surface.5. The apparatus of claim 4 , wherein the surface is a portion of a tissue claim 4 , wherein a measurement from the plurality of sensing elements provides an indication of an arrhythmia condition of the tissue.6. The apparatus of claim 4 , wherein the surface is a portion of a tissue claim 4 , wherein a measurement from the plurality of sensing elements provides an indication of an artial fibrillation or a ventricular fibrillation of the tissue.7. The apparatus of claim 1 , wherein the flexible substrate forms an inflatable body claim 1 , and wherein a portion of the at least one intermediate bus is disposed about a distal region of the inflatable body.8. The apparatus of claim 7 , wherein the ...

System and Method for Diagnosing Arrhythmias and Directing Catheter Therapies

An efficient system for diagnosing arrhythmias and directing catheter therapies may allow for measuring, classifying, analyzing, and mapping spatial electrophysiological (EP) patterns within a body. The efficient system may further guide arrhythmia therapy and update maps as treatment is delivered. The efficient system may use a medical device having a high density of sensors with a known spatial configuration for collecting EP data and positioning data. Further, the efficient system may also use an electronic control system (ECU) for computing and providing the user with a variety of metrics, derivative metrics, high definition (HD) maps, HD composite maps, and general visual aids for association with a geometrical anatomical model shown on a display device.

SINGLE CHANNEL MRI GUIDEWIRE

The present application discloses a guidewire for magnetic resonance imaging with a single channel design to reduce complexity and to provide conspicuous tip visibility under MRI. In one embodiment, a guidewire body includes an antenna formed from a rod and a helical coil coupled together. The helical coil can have multiple windings without any gaps between the windings. The rod passes through the windings of the helical coil and is coupled to the helical coil using a conductive joint positioned at an end of the rod and at an end of the helical coil. Insulation can be positioned between the rod and the windings of the helical coil. The configuration allows visibility of the antenna along the length of a rod, except where it enters the windings of the coil. Thus, the tip visibility is enhanced as being separated from the rod. 1. A guidewire for use with magnetic resonance imaging , comprising:a guidewire body having a distal end and a proximal end;an antenna disposed in the guidewire body, the antenna being formed from a rod passing through the guidewire body and a helical coil positioned at the distal end, the helical coil having multiple windings without a gap between the windings;the rod passing through the windings of the helical coil and coupled to the helical coil using a conductive joint positioned at an end of the rod and at an end of the helical coil; andinsulation positioned between the rod and the windings of the helical coil.2. The guidewire of claim 1 , wherein the rod is formed from a non-magnetic material.3. The guidewire of claim 1 , wherein the conductive joint is an electrical connection.4. The guidewire of claim 1 , wherein the rod has a first diameter for a first portion of the rod claim 1 , which is positioned outside of the windings of the helical coil claim 1 , and a second diameter for a second portion of the rod that is positioned within the windings.5. The guidewire of claim 1 , wherein the conductive joint has a semispherical shape so as to ...

Systems and methods for a low-profile vascular pressure measurement device

A measuring system includes an elongated sleeve having a compact diameter configured to be delivered over a standard guide wire and able to be flexibly threaded into a tortuous or diseased vascular pathway of a human. Sensor(s), located at a distal end of the sleeve, measure physiological parameter(s) inside the human. The sleeve measuring system has an outer diameter of approximately 20 mils or less and is capable of accommodating the standard guide wire, typically 14 mils in diameter.

Haptic system for balloon tipped catheter interventions

Embodiments of this invention include hand-held handles and systems for balloon-tipped catheter interventions that enable a user to appreciate a combination of palpable sensations as though his or her hand is actual anatomic tissue in situ in real time. The system may include a haptic handle coupled to the proximal end of the catheter where the haptic handle includes a balloon-shaped haptic interface that exhibits geometric characteristics reflecting an anatomy of the interventional balloon and provides tangible sensations representative of tissues surrounding the interventional balloon. Multiple sensors and actuators may be used to create a non-virtual, transparent experience communicated to a user with a three dimensional, volumetric haptic display. In one embodiment, the sensors are positioned about or within an inflatable balloon positioned at the distal aspect of an inserted catheter used to treat cardiac and vascular diseases such as coronary or peripheral vascular occlusion and ablation of cardiac tissue.