ВНУТРИПРОСВЕТНЫЙ СОСУДИСТЫЙ ПРОТЕЗ

Изобретение относится к медицине, а именно к сердечно-сосудистой хирургии. Изобретение обеспечивает протезирование для перекрытия абдоминальной аортальной аневризмы. Протез содержит трубчатый проволочный каркас с проксимальным и дистальным концом и проходящий через протез центральный просвет. Каркас содержит, по меньшей мере, первый и второй смежные в осевом направлении трубчатые сегменты. Каждый трубчатый сегмент содержит последовательность проксимальных и дистальных изгибов. Трубчатые сегменты соединены проходящим между ними соединителем. Первый и второй сегменты и соединитель выполнены из одного куска проволоки. По меньшей мере, первый дистальный изгиб в первом трубчатом сегменте соединен, по меньшей мере, с первым проксимальным изгибом во втором трубчатом сегменте. По меньшей мере, первый проксимальный изгиб и первый дистальный изгиб содержат на себе петлю. Изобретение также касается способа изготовления внутрипросветного протеза, многозонного внутрипросветного протеза и способа имплантации ...

ЭНДОПРОТЕЗ С ВЫРОВНЕННЫМИ НОЖКАМИ ДЛЯ УПРОЩЕНИЯ КАНЮЛЯЦИИ

... 1. Разветвленный эндопротез, содержащий:трансплантатный компонент и по меньшей мере один опорный компонент, совместно определяющие корпусную часть, первую ножечную часть и вторую ножечную часть; иразъемное крепление, выравнивающее первую ножечную часть и вторую ножечную часть относительно друг друга для упрощения канюляции второй ножечной части.2. Эндопротез по п. 1, в котором разъемное крепление содержит привязь, торцевая оконечность которой заправлена под неразвернутые части муфты, окружающей разветвленный эндопротез.3. Эндопротез по п. 1, в котором разъемное крепление содержит привязь, торцевая оконечность которой пропущена под одной или несколькими вершинами по меньшей мере одного опорного компонента.4. Эндопротез по п. 1, в котором первая ножечная часть, по существу, аксиально длинней второй ножечной части.5. Эндопротез по п. 1, в котором первая ножечная часть и вторая ножечная часть конструктивно отклонены под углом в разные стороны, образуя Y-образную конфигурацию.6. Эндопротез по ...

VORRICHTUNG ZUR BEHANDLUNG VON BLUTGEFÄSSEN

STENTZUFÜHRVORRICHTUNG UND -VERFAHREN

STENT MIT KOLLAGEN

UMMANTELTE ENDOPROTHESE

VERFAHREN UND VORRICHTUNG ZUR GESTALTUNG VON GEFÄSSPROTHESEN

PROTHESE AUS GEFLOCHTENEM VERBUNDMATERIAL

Selbstausdehnbares Stentgewebe

Stent-Graft mit erhöhter Flexibilität

Self-expanding stent for reinforcing and/or keeping open a hollow organ comprise two elastic tubular layers which bracket and positionally fix at least one helical filament

The self-expanding stent (10) for reinforcing and/or keeping open a hollow organ comprise two elastic tubular layers (11, 14) which bracket and positionally fix at least one helical filament (12), and are joined one another at least at their ends by material bonds.

Device for application in blood vessels or other difficultly accessible locations

PCT No. PCT/SE82/00283 Sec. 371 Date May 5, 1983 Sec. 102(e) Date May 5, 1983 PCT Filed Sep. 15, 1982 PCT Pub. No. WO83/00997 PCT Pub. Date Mar. 31, 1983.Device comprising a helically shaped spiral spring and means for bringing the spring to expand from a first state of a certain diameter to a second state of larger diameter and vice versa, characterized thereby that said means are arranged to rotate the ends of the spring relative to each other with maintained length of the spring so that the transition from said first state to said second state takes place by reducing the number of spring turns within said length and the corresponding increase of the pitch of the spring, or to supply to a given length of the spring further spring material at at least one end of the said length of the spring so that the transition from said first state to said second state takes place independent of pitch and number of spring turns within the said length; and a method for transluminal implantation of an ...

Method of manufacturing stent attached to artificial blood vessel and stent attached to artificial blood vessel manufactured by the same

A method of manufacturing an artificial blood vessel attached stent, the method comprising forming a stent 10 having a hollow cylindrical body by cross weaving a super-elastic shape memory alloy wire 2, performing attachment preparation by forming an inner artificial blood vessel layer 31 by inclined winding an artificial blood vessel (PTFE, polytetrafluoroethylene) 5 along the outer side of a rod 20 to form an inner artificial blood vessel layer 31, inserting the inner artificial blood vessel layer 31 into the stent 10. Winding an artificial blood vessel 5 along an outer side of the stent 10 to form an outer artificial blood vessel layer 32, and inserting a silicon tube 40. Fixedly mounting the rod 20 inside a vacuum heating device 50, attaching the inner artificial blood vessel layer 31 and the outer artificial blood vessel layer 32 positioned at the inside and outside of the stent to each other by vacuuming operation towards the stent 10 with the inner artificial blood vessel layer 31 ...

A tubular conduit with an internal and external helical formation

A tubular conduit (1) comprising a tubular portion (2) made from a flexible material. There is an external helical formation (7) extending around the exterior of, and parallel to the axis of, the tubular portion (2) and defining a first region of the tubular portion (2). The external helical formation (7) is for supporting the tubular portion (2). There is also an internal helical formation (10), protruding inwardly of the interior of the tubular portion (2) and extending parallel to the axis of the tubular portion (2) and defining a second region of the tubular portion (2). The internal helical formation (10) is for imparting helical flow on fluid passing through the tubular portion (2). The first region does not extend throughout the second region but may overlap the second region. An external helical formation may also be provided (11) corresponding to the internal helical formation (10) to provide some support for the conduit in the second region of the conduit. The arrangement provides ...

Stent graft devices having collagen coating

EINRICHTUNG ZUR BEHANDLUNG VON BLUTGEFAESSEN OD.DGL.

PCT No. PCT/SE82/00283 Sec. 371 Date May 5, 1983 Sec. 102(e) Date May 5, 1983 PCT Filed Sep. 15, 1982 PCT Pub. No. WO83/00997 PCT Pub. Date Mar. 31, 1983.Device comprising a helically shaped spiral spring and means for bringing the spring to expand from a first state of a certain diameter to a second state of larger diameter and vice versa, characterized thereby that said means are arranged to rotate the ends of the spring relative to each other with maintained length of the spring so that the transition from said first state to said second state takes place by reducing the number of spring turns within said length and the corresponding increase of the pitch of the spring, or to supply to a given length of the spring further spring material at at least one end of the said length of the spring so that the transition from said first state to said second state takes place independent of pitch and number of spring turns within the said length; and a method for transluminal implantation of an ...

A-TOTALLY ENCLOSED STENT GRAFT WITH CONNECTION BETWEEN THE GRAFTHÜLLEN

DRUG OF DELIVERING ENDOVASKULÄRER STENT

RADIATIONIMPERMEABLE MEDICAL DEVICES FROM EPTFE

CONTAINER PROSTHESES WITH IMPROVED FLEXIBILITY AND A DELIVERY CONFIGURATION WITH INTERLOCKED CELLS

BREAK CELEBRATION ENDOVASKULÄRES IMPLANT

ENDOVASKULARES EQUIPMENT

GRADIENT-COATED STENT AND MANUFACTURING PROCESS FOR IT

ENDOVASKULÄRER STENT GRAFT

STENTSYSTEM

SPREAD-CASH INTRALUMINALES FABRIC AND EQUIPMENT FOR IMPLANTIEREN THIS SPREAD-CASH INTRALUMINALEN OF FABRIC.

ENDOLUMINALE VASCULAR PROSTHESIS

SEGMENTED STENT GRAFT

MEDICAL INSTRUMENT WITH WINDOW

STENT WITH KOLLAGEN

SCREW-SHAPED EDUCATION STENT/TRANSPLANTAT

WOVEN PIPE FOR STENTARTIGE CONTAINER PROSTHESIS AND CONTAINER PROSTHESIS WITH THIS PIPE

RADIALLY EXPAND-CASH POLYTETRAFLUORETHYLENE AND OUT OF IT FIGURATION EXPAND-CASH ENDOVASKULÄRE STENTS

MANUFACTURING PROCESS FOR VASCULAR PROSTHESIS WITH LARGE DIAMETER AS WELL AS BY THIS PROCEDURE MANUFACTURE VASCULAR PROSTHESIS

SELFEXPAND-CASH STENTGEWEBE

MECHANISM FOR FOLDING UP A FOLD UP-CASH AND FLEXIBLE AGAIN IN FORM BRING-CASH INTO A HUMAN ORGAN APPLICABLE DEVICE

EPTFE GRAFT WITH AXIAL STRETCH CHARACTERISTICS

CONTAINER TRANSPLANT FROM PTFE AND PROCEDURE FOR ITS PRODUCTION

STENT FOR THE OESOPHAGUS

STENCILS ON BASIS MANUFACTURED BY KOLLAGEN AND SYNTHETIC ONE POLYMER USING A MULTI-LEVEL REACTION

Stent grafts containing purified submucosa

Radially expandable stent featuring aneurysm covering surface

Expandable stent with wrinkle-free elastomeric cover

An improved stent-graft device is provided that delivers a smooth flow surface over a range of operative expanded diameters by applying a unique cover material to the stent through a technique that allows the cover to become wrinkle-free prior to reaching fully deployed diameter. The unique cover material then allows the device to continue to expand to a fully deployed diameter while maintaining a smooth and coherent flow surface throughout this additional expansion. Employed with a self-expanding device, when the device is unconstrained from a compacted diameter it will self-expand up to a fully deployed diameter with the graft being substantially wrinkle-free over diameters ranging from about 30-50% to 100% of the fully deployed diameter. Preferably, the graft component comprises an elastomeric material, such as silicone, polyurethane, or a copolymer of PAVE-TFE.

HIGH STRENGTH VACUUM DEPOSITED NITIONOL ALLOY FILMS, MEDICAL THIN FILM GRAFT MATERIALS AND METHOD OF MAKING SAME

Stent and method of making a stent

A stent (42) for use in a stent graft comprising a strut region comprising at least two struts (46,48), the struts having at least one radius of curvature; a bend connecting the at least two struts and forming an eyelet region (54), where the strut region and the eyelet region are electropolished and the eyelet region is locally polished; and an eyelet (54) positioned in the eyelet region, having at least one radius of curvature greater than zero is provided. A method of manufacturing the same also is disclosed.

Encapsulated stent-graft with graft to graft attachment

Stent device

Disclosed is a stent device (1) in which a stent (3) that supports a blood vessel from inside is held by a stent cover member (4). Said stent device comprises a tube-shaped cartridge (2), a stent, and a stent cover member. The tube-shaped cartridge can expand and contract radially, but axial elongation thereof is restricted. The stent, which is formed into a tube shape from a bioabsorbable shape-memory polymer material, stores a shape which is equal or larger in diameter than the inside diameter of a blood vessel. In a contracted state, the stent is fitted around the outer surface of the tube-shaped cartridge. The stent cover member, which comprises an elastic bioabsorbable polymer material, is formed into a tube shape that has an inner diameter such that the stent is held in the aforementioned contracted state, and when the stent expands to the size stored therein, the stent cover member plastically deforms such that the stent is no longer held. As the tube-shaped cartridge expands radially ...

Helical hybrid stent

An expandable helical stent is provided, wherein the stent may be formed of a main stent component and a securement. The main stent component is formed from a flat strip having one or more undulating side bands (401, 402) that may be connected to form geometrically shaped cells (430) and are helically wound to form a stent. The helical coils of the main stent component may be spaced apart or nestled to each other. The nestling of the undulation of adjacent helical windings contributes to maintaining the tubular shape and uniformity of the helically coiled stent. Alternatively, the flat strip may comprise a single undulating pattern. At the ends of the main stent component are end bands 407), which when wound, form a cylindrical ring. In one embodiment, one or more struts of the main stent component may have a width sufficient to include one or more fenestrations. The fenestrated struts may be connected by loops or turns wherein the material is narrower than that of the fenestrated struts ...

Covered segmented stent

Encapsulated radiopaque markers

Devices and methods related to deposited support structures

The present disclosure describes medical devices comprising a bio-corrodible stent member and a graft member. The bio-corrodible stent member can comprise a metal applied directly to the graft member via a vapor deposition process, such as a chemical or physical vapor deposition process.

Customized aortic stent device and method of making the same

The application provides customized aortic stent and stent graft devices and methods for the manufacture thereof. The customized aortic stent or stent graft are patient-specific in that they conform to at least part of the ascending aorta, aortic arch and/or thoracic aorta.

Branched vessel endoluminal device

An endoluminal prosthesis (520) comprises a prosthetic trunk having a trunk lumen and a trunk wall, a first prosthetic branch (533) having a first branch lumen and a branch wall, and a second prosthetic branch (534) having a second branch lumen. The first branch lumen and the second branch lumen are both in fluid communication with the trunk lumen through the trunk wall and the second branch lumen is in fluid communication with the first branch lumen through the branch wall. Additional devices, systems, and methods are disclosed.

Implantable biocompatible tubular material

The present disclosure describes medical devices comprising a biocompatible tubular material. Such devices can include graft members for implanting in the vasculature of a patient. The tubular material of these graft members can be relatively thin, while providing comparable or improved performance over conventional graft members.

A stent graft with double ePTFE-layered-system with high plasticity and high rigidity

A vascular prosthesis and method are disclosed comprising a first flexible stent having a lattice structure with a compacted configuration and an expanded configuration, a second flexible stent inside the first flexible stent to form a tubular structure, a first film layer of graft material such as expanded polytetrafluoroethylene sandwiched between the first and second flexible stents, and a second film layer of expanded polytetrafluoroethylene sandwiched between the first and second flexible stents, the second layer having a higher rigidity and a lower plasticity than the first layer.

Applicator instruments for dispensing surgical fasteners having articulating shafts and articulation control elements

An applicator instrument for dispensing surgical fasteners includes a handle and an articulating shaft extending from the distal end of the handle. The articulating shaft includes a proximal shaft section, a distal shaft section, and an articulating joint. An articulation control element is coupled with the proximal shaft section for articulating the distal shaft section relative to the proximal shaft section via the articulating joint. The applicator instrument includes an incompressible member interconnecting the proximal and distal shaft sections that maintains a fixed distance between the distal end face of the distal shaft section and the distal end of the handle as the articulating shaft moves between a straight configuration and an articulated configuration to ensure a consistent firing stroke.

Covered Stent

Abstract The utility discloses a covered stent, which comprises a reticular bare stent and a mesenteric layer, the reticular bare stent curling inward to form a cylindrical shape, and the mesenteric layer is fixed on the outer or inner wall of the reticular bare stent. The utility relates to a membranous scaffold, which has good biocompatibility and can be well attached to the blood vessel wall to support the stenosis of the blood vessel and close the rupture of the blood vessel, reduce the occurrence of inflammatory reaction, and is not easy to form mural thrombus; Convenient storage, low preparation and storage cost. Figures Figure ...

Covered expanding mesh stent

A surgical graft/stent system

Spider silk covered stent

Multi-stage expandable stent-graft

Endoluminal vascular prosthesis

A biliary stent-graft

An implant comprising a support structure and a transition material made of porous plastics material

ARTERIAL GRAFT PROSTHESIS

REINFORCED GRAFT

A graft is provided with a flexible sheet (10) of graft material to which is sewn a reinforcing wire (12), preferably of shape-memory alloy. Sewing of the wire (12) is carried out while the sheet (10) is substantially planar, thus by conventional embroidery machines. The sheet (10) is subsequently rolled into a tubular shape.

IMPLANTABLE OR INSERTABLE MEDICAL DEVICES FOR CONTROLLED DRUG DELIVERY

Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device. Methods for manufacturing implantable or insertable medical ...

DELAYED MEMORY DEVICE

... ²²²A device for reshaping a cardiac valve (26), which is elongate and has such ²dimensions as to be insertable into a cardiac vessel (24). The device has two ²states, in a first state (K) of which the device has a shape that is adaptable ²to the shape of the vessel (24), and to the second state (k') of which the ²device is transferable from said first state (K). Further, the device ²comprises a fixing means (22,23;22a,23a) for fixing the ends of the device ²within the vessel (24), when the device is first positioned therein, a shape-²changing member (20;20a) for transferring the device to the second state (K') ²by reshaping it, and a delay means (21;21a) for delaying said reshaping until ²the fixing of the ends of the device has been reinforced by keeping said ²device in said first state (K) until the delay means (21;21a) is resorbed.² ...

LOW PROFILE STENT AND GRAFT COMBINATION

Large diameter self-expanding endoprosthetic devices, such as stents and stent grafts for delivery to large diameter vessels, such as the aorta, are disclosed having very small compacted delivery dimensions. Devices with deployed dimensions of 26 to 40 mm or more are disclosed that are compacted to extremely small dimensions of 5 mm or less, enabling percutaneous delivery of said devices without the need for surgical intervention. Compaction efficiences are achieved by combining unique material combinations with new forms of restraining devices, compaction techniques, and delivery techniques. These inventive devices permit consistent percutaneous delivery of large vessel treatment devices. Additionally, small endoprosthetic devices are disclosed that can be compacted to extremely small dimensions for delivery through catheter tubes of less than 1 mm diameter.

CONTROLLED DEPLOYABLE MEDICAL DEVICE AND METHOD OF MAKING THE SAME

Controlled deployable medical devices that are retained inside a body passage and in one particular application to vascular devices used in repairing arterial dilations, e.g., aneurysms. Such devices can be adjusted during deployment, thereby allowing at least one of a longitudinal or radial re-positioning, resulting in precise alignment of the device to an implant target site.

STENT-GRAFT-MEMBRANE AND METHOD OF MAKING SAME

A braided self-expandable stent-graft-membrane made of elongated members forming a generally tubular body. A membrane layer and graft layer are disposed on an endoprosthesis such as a stent. The membrane layer is substantially impermeable to fluids. The outermost layer is biocompatible with the body tissue. The innermost layer is biocompatible with the fluid in the passage. An embodiment includes a graft layer disposed on the inside of a stent and a membrane layer disposed on the outside of the stent. The innermost layer is biocompatible with the fluid in the passage. The stent-graft-membrane is used at a treatment site in a body vessel or organ where it is desirous to exclude a first fluid located outside the endoprosthesis from reaching a second fluid located in the lumen. The membrane may be made of silicone or polycarbonate urethane. The graft may be braided, woven, spun or spray-cast PET, PCU, or PU fibers. The layers may include ePTFE or PTFE.

MULTI-STAGE EXPANDABLE STENT-GRAFT

... ▓▓▓An improved device for use in a conduit, such as a blood vessel, is provided. ▓The device uniquely combines desirable properties from two distinct previous ▓devices. The device (10) of the present invention assumes and is constrained ▓to a first diametrical dimension (14) for insertion into the conduit. Once ▓inserted and properly positioned in the conduit the device (10) expands to a ▓second diametrical dimension within the conduit when the constraint is ▓removed. The device (10) can then be dilated to one or more enlarged third ▓diametrical dimensions by using a balloon catheter or similar device. The ▓result is a device (10) that provides desirable properties of both self-▓expanding stents and balloon-expandable endoprostheses. The device (10) can be ▓employed in a variety of applications.▓ ...

METHOD AND APPARATUS FOR MANUFACTURING AN ENDOVASCULAR GRAFT SECTION

A device and method for the manufacture of medical devices, specifically, endovascular grafts (16), or sections thereof. Layers of fusible material (13) are disposed upon a shape forming member (14) and seams (81) formed between the layers in a configuration that can produce inflatable channels (82) in desired portions of the graft. After creation of the seams (81), the fusible material of the inflatable channels may be fixed in a mold (90) to constrain an outer layer or layers of fusible material while the channels (82) are being expanded. A joint (330) may be produced on the endovascular graft by folding a flap (333) of a flexible material portion of an endovascular graft about a portion of an expandable member (314) to form a loop portion (348). The flap (333) may be secured in the loop configuration (348) so that tensile force on the expandable member (314) is transferred into a shear force on the fixed portion of the flap.

ENDOLUMINAL ENCAPSULATED STENT AND METHODS OF MANUFACTURE AND ENDOLUMINAL DELIVERY

MEDICAL DEVICES

Endoprostheses including composites, and methods of making the endoprosthesis, are disclosed. The composites include at least a first material and a second material having different chemical compositions from each other.

EPTFE GRAFT WITH AXIAL ELONGATION PROPERTIES

An improved ePTFE material and method of preparing the improved ePTFE material provides a tubular structure with enhanced axial elongation, radial expansion, and physical recovery characteristics.

FLOW RESTRICTING STENT-GRAFT

The presently described stent-graft includes a stent frame forming a cavity and frame wires extending around the stent frame perimeter. The stent frame is formed such that the cavity cross sectional area decreases along a first length of a flow restricting section to a cavity minimum cross sectional area and increases along a second length of the flow restricting section. The first length extends from a cavity proximal cross sectional area to the cavity minimum cross sectional area and the second length extends from the cavity minimum cross sectional area to a cavity distal cross sectional area. When placed within a patient's aorta, the stent-graft may help the treatment of congestive heart failure by increasing blood flow to the kidneys. The provided stent-graft may also be adapted for placement within a patient's urethra to help the treatment of urinary incontinence.

APPLICATOR INSTRUMENTS FOR DISPENSING SURGICAL FASTENERS HAVING ARTICULATING SHAFTS AND ARTICULATION CONTROL ELEMENTS

An applicator instrument for dispensing surgical fasteners includes a handle and an articulating shaft extending from the distal end of the handle. The articulating shaft includes a proximal shaft section, a distal shaft section, and an articulating joint. An articulation control element is coupled with the proximal shaft section for articulating the distal shaft section relative to the proximal shaft section via the articulating joint. The applicator instrument includes an incompressible member interconnecting the proximal and distal shaft sections that maintains a fixed distance between the distal end face of the distal shaft section and the distal end of the handle as the articulating shaft moves between a straight configuration and an articulated configuration to ensure a consistent firing stroke.

DIAMETRICALLY ADJUSTABLE ENDOPROSTHESES AND ASSOCIATED SYSTEMS AND METHODS

A diametrically adjustable endoprosthesis includes a controlled expansion element extending along at least a portion of a graft and is supported by a stent. The controlled expansion element diametrically constrains and limits expansion of the endoprosthesis. Upon deployment from a smaller, delivery configuration, the endoprosthesis can expand to the initial diameter set by the controlled expansion element. Thereafter, the endoprosthesis can be further diametrically expanded (e.g., using balloon dilation) by mechanically altering the controlled expansion element.

PROSTHESIS FOR REPAIRING A BLOOD VESSEL AND METHOD

A prosthesis for repairing a blood vessel, wherein the prosthesis is inserted intraluminally and fixed in the vessel so as to isolate a diseased section thereof and maintain the flow of blood from the vessel to collateral vessels involved in the diseased section, and the prosthesis comprises a stent support and a flexible fabric liner of woven material comprising a plurality of concentric layers, wherein each of said layers has a very open fabric web which allows the passage of blood flow through the layers during the installation of the prosthesis but which allows the sealing of layers once the prosthesis is installed. A method is also provided for safe installation of the prosthesis.

COVERED STENTS WITH SIDE BRANCH

A system for treating stenosis in a target blood vessel, such as the common carotid artery, comprising a graft portion having a main portion and a branch portion extending therefrom. The branch portion extends from the intermediate portion of the main portion at an angle thereto and is in fluid communication with the main portion. A first stent is associated with the main portion and is expandable from a first configuration to a second configuration to retain the main portion in position within the target vessel. A second stent is associated with the branch portion and is expandable from a first configuration to a second configuration to retain the branch portion in position within a branching vessel. In one embodiment, the branch portion is integral with the main portion. In an alternate embodiment the branch portion is connected to the main portion.

THIN-LAYERED, ENDOVASCULAR, SILK-COVERED STENT DEVICE AND METHOD OF MANUFACTURE THEREOF

A stent-graft composite intraluminal prosthesis comprises an elongate radially adjustable tubular stent, defining opposed exterior and luminal stent surfaces and a polymeric stent sheath covering at least the exterior surface thereof. The stent can include a plurality of open spaces extending between the opposed exterior and interior surfaces so as to permit said radial adjustability. The stent has a polymeric material on its exterior surface, its interior surface, in interstitial relationship with the stent or any combination of the above. The polymer is preferably selected from the group of polymeric materials consisting of biological or genetically engineered spider silks, such as those derived fromNephila clavipes. The silk includes bioengineered spider silks as well as silk-like polymers manufactured using human proteins and blends of such silks with commonly used polymeric graft materials. If separate sheaths are placed on both the exterior and interior surfaces of the stent, the ...

ENDOVASCULAR APPARATUS

Percutaneous treatment of aortic aneurysms and like vascular anomalies by an apparatus and method wherein the apparatus is delivered via catheter and comprises s sleeve with at least one peripheral conduit which is caused to assume are expanded, rigid configuration by the introduction of a chemical or mechanical hardening means, whereby the sleeve is caused to assume an open cylindrical configuration for fluid flow therethrough.

ENDOLUMINALLY PLACED VASCULAR GRAFT

A delivery system and device for re-lining bodily vessels. A stent (22) is attached to a distal end of a tubular lining (20) made of biocompatible material and loaded into a hollow atraumatic tip (32). A semi-rigid shaft (30) connects the atraumatic tip to a stopper (36) and runs through the center of the tubular lining (20). The proximal end of the tubular lining (20) is attached to a sliding hub (28). Optionally, a balloon (34) is positioned near the stent in fluid communication with the shaft. The assembled device is introduced into a bodily vessel (40) following an endarterectomy or atherectomy procedure. The atraumatic tip (32) is delivered to a pre- determined location and upon reaching that destination, the stent (22) is released from the tip (32) to expand against the vessel wall. If a balloon (34) is utilized, it is inflated to ensure that the stent (22) is fully deployed within the vessel. The balloon (34) is then deflated and the tip (32) and shaft (30) are pulled through the ...

LAYERED STENT-GRAFT AND METHODS OF MAKING THE SAME

A stent-graft (10) made of at least three concentric layers (12, 14, 16) is disclosed. The inner and outer layers (16, 12) can be porous. The middle layer (14) can be non-porous and encompasses a stent (18).

DRUG-IMPREGNATED ENCASEMENT

INTRALUMENAL STENT GRAFT FIXATION

This document describes intralumenal stent graft devices with integrated anchor members that are selectively deployable in situ. The deployment of the anchor members is also reversible, to thereby facilitate retrieval of the stent graft device. These stent graft devices are well-suited for sealing and repairing defects in a body lumen wall. Such defects can include, but are not limited to, aneurysms and lumen wall openings. In some embodiments, the intralumenal stent graft devices provided herein are well-suited for use in the GI tract including the colon. That is the case because the integrated anchor members provide the stent graft devices with a high level of migration resistance, whereby the stent grafts can remain resiliency located in a desired position within the GI tract despite the peristaltic movements of the GI tract.

ARTIFICIAL VASCULAR GRAFT

The invention relates to an artificial vascular graft comprising a primary scaffold structure encompassing an inner space of the artificial vascular graft, said primary scaffold structure having an inner surface facing towards said inner space and an outer surface facing away from said inner space, a coating on said inner surface, wherein a plurality of grooves is comprised in said coating of said inner surface. The primary scaffold structure comprises further a coating on said outer surface. The primary scaffold structure and the coating on said inner surface and on said outer surface are d designed in such a way that cells, in particular progenitor cells, can migrate from the periphery of said artificial vascular graft through said outer surface of said coating, said primary scaffold structure and said inner surface to said inner space, if the artificial vascular graft is used as intended. The invention relates further to a method for providing said graft.

ENDOPROSTHESIS HAVING ALIGNED LEGS FOR EASE OF CANNULATION

The present disclosure is directed to a branched endoprosthesis comprising a graft component and at least one support component. In various embodiments, the branched endoprosthesis comprises a body portion and at least two leg portions, wherein at least two legs are in an aligned configuration for ease of cannulation. The endoprosthesis comprises a removable restraint (245) aligning the two legs relative to each other. In various embodiments, at least one leg is in an open configuration for ease of cannulation. Cannulation methods are also taught.

ENDOPROSTHESIS WITH VARYING COMPRESSIBILITY AND METHODS OF USE

The present disclosure is directed to an endoprosthesis comprising a graft component and at least one support component with varying compressibility along the length of the endoprosthesis. In various embodiments, the endoprosthesis comprises at least a first segment and a second segment, wherein the first segment is more compressible than the second. In another embodiment having a second segment between the first and third segments, the third segment can also be more compressible than the second segment. Altematively, in an embodiment, a second segment can have greater rigidity than a first segment, as well as a third segment, if present.

MULTILAYERED BIODEGRADABLE STENT AND METHOD FOR ITS MANUFACTURE

A stent of multilayered laminated construction wherein one layer addresses the structural requirements of the stent and additional layers release drugs at predictable rates. Both the structural layer as well as the drug releasing layers are eventually completely resorbed by the body.

ENDOLUMINAL ENCAPSULATED STENT AND METHODS OF MANUFACTURE AND ENDOLUMINAL DELIVERY

A radially expandable stent-graft and method of making the same, including a t least one stent member encapsulated between at least two longitudinally expanded polytetrafluoroethylene (ePTFE) coverings. The a t least one stent member (22) has openings through wall surfaces of the stent to permit radial expansion. The at least two longitudinally expanded ePTFE coverings (24, 26) are circumferentially applied over the at least one stent member in their unsintered state, and sintered during application of a circumferential pressure to bond the ePTFE around and through the wall surfaces of the stent (22). The sintered ePTFE forms a substantially continuous, monolithic and integral encapsulation of the at least one stent. Upon radial expansion of the stent graft (10), the stent and the ePTFE node-fibril microstructure radially deform. Radial deformation of the ePTFE encapsulation results in nodal elongation in the axis of radial expansion. After radial expansion of the stent-graft (10), a substantial ...

RADIALLY EXPANDABLE VASCULAR GRAFT WITH RESISTANCE TO LONGITUDINAL COMPRESSION AND METHOD OF MAKING SAME

A microporous polytetrafluoroethylene endovascular graft (10) which has a reinforcing structure (16) integrally bound to the graft which permits radial expansion of the graft and stabilizes the graft against longitudinal compression upon application of an axial force thereto and against axial foreshortening upon radial expansion of the graft. The graft is particularly useful as a covering for an endovascular stent.

EXPANDABLE SUPPORTIVE BIFURCATED ENDOLUMINAL GRAFTS

An endoluminal graft which is both expandable and supportive is provided in a form suitable for use in a bifurcated body vessel location. The graft expands between a first diameter and a second, larger diameter . The support component is an expandable stent endoprosthesis. A cover, a liner, or both a cover and a liner are applied to the endoprosthesis in the form of a stretchable wall material that is porous, elastomeric and biocompatible in order to allow normal cellular invasion upon implantation, without stenosis, when the expandable and supportive graft is at its second diameter. The supportive endoluminal graft is preferably provided as a plurality of components that are deployed separately at the bifurcated body vessel location.

CONTROLLED POROSITY ENDOVASCULAR IMPLANT

A covered stent for treating a stenotic region in a blood vessel. The stent covering has different porosities in different regions. In those regions, typically the ends, where tissue ingrowth and re-endothelialization are desired, the stent covering is more porous, and in those regions were it is desirable to inhibit such ingrowth, the stent covering is substantially non-porous.

MULTI-STAGE PROSTHESIS

A porous fluoropolymer article forms an artificial internal organ, for example, a vascular bypass, vascular access, or endovascular prosthesis. PTFE having a fibrous structure of nodes and fibers connecting the nodes together forms a wall with radial zones of differing porosity in a porous tube. In one aspect an integrated intrawall circumferential support adjacent to areas of variable porosity provides enhanced tunneling and cannulizability. In another aspect, the wall of a prosthesis has a region which modulates communication through the porosity of the wall. The prosthesis is unitary, but may be assembled in successive bodies which are coalesced, so that the porous microstructure changes distinctly at stages through the thickness dimension of the wall. One embodiment is formed entirely of fluoropolymer, and has at least one surface adapted to support tissue regeneration and ingrowth. The modulation region is a stratum of high water entry pressure that reduces pulsatile hydraulic pressure ...

STENT GRAFTS CONTAINING PURIFIED SUBMUCOSA

A graft construct and method for repairing the inner linings of damaged or diseased vessels is described. The method comprises the steps of positioning a graft construct within a blood vessel at a site in need of repair. The graft construct comprises purified submucosa removed from a submucosa tissue source.

CONFORMAL LAMINATE STENT DEVICE

A method and apparatus for forming a covered endoprosthesis employs a conformed polymeric coating about an expandable stent. The expandable stent has an open tubular construction. A first polymeric lin er is positioned about an inner surface of the tubular stent and a second polymeric liner is positioned about an outer surface of the tubular stent. The first and second polymeric liners are conformed to the tubular stent and laminated together through the open construction of th e stent at a location coextensive with the inner surface of the tubular stent.

EXPANDABLE DEVICE IMPLANTABLE IN A CONDUIT OF A LIVING BEING, SUCH AS A BLOOD VESSEL.

Medical stent

A medical stent (1) is provided with: a coil (3) formed by winding a wire (2) around an axis (C1); an outer layer (4) formed in a roughly tubular shape of a first resin material and provided on the outer circumference of the coil; an inner layer (5) formed in a roughly tubular shape and provided on the inner circumference of the coil; and an elastic part (6) formed of a second resin material differing from the first resin material and formed so that a surface-treated part (6b) formed on the outer circumferential surface at one end (6a) contacts and is fixed to the outer circumferential surface of an end of the outer layer and the other end (6c) extends along the axis towards the midpoint of the outer layer while opening outward in the radial direction of the outer layer. The temperature at which the second resin material melts is higher than the temperature at which the first resin material melts, and the surface-treated part of the elastic part and the outer circumferential surface of ...

Satiation devices and methods

A device for inducing weight loss in a patient includes a tubular prosthesis self-expandable from a collapsed position in which the prosthesis has a first diameter to an expanded position in which the prosthesis has a second, larger, diameter. In a method for inducing weight loss, the prosthesis is placed in the collapsed position and inserted into a stomach of a patient. The prosthesis is allowed to self-expand from the collapsed position to the expanded position and into contact with the walls of the stomach, where it induces feelings of satiety and/or inhibits modulation of satiety-controlling factors such as Ghrelin.

Hydrogel jacketed stents

Hydrogel jacketed stents provide the ability to fill in the stent frame in vivo to at least partially cover the interior of the surface of the stent following deployment while having the convenience of attaching the jacket to the exterior of the stent. The hydrogel can be pleated and/or folder over the exterior of the stent to provide for extension of the stent without damaging the hydrogel. The hydrogel sheet can be secured at one or more points along the circumference to associate the sheet of hydrogel with the exterior surface of the stent frame. The stent can be conveniently delivered using similar technology as conventional stents if desired. The hydrogel can provide for drug delivery if desired.

Stent Graft System

The stent graft system in accordance with the present invention has a trunk, a left subclavian tube, a left common carotid tube and a brachiocephalic tube. The trunk is tubular and expandable and has a descending end, an ascending end, a left subclavian mount, a left common carotid mount and a brachiocephalic mount, for receiving the aforementioned branch tubes that are elastic and self-expandable for respectively connecting the left subclavian artery, the left common carotid artery and the brachiocephalic artery to the trunk. With the above-described structure, the present invention allows fast determination of a suitable trunk and branch tubes for a patient and allows a medical institute to prepare compatible branch tubes and trunks for a composite stent graft system instead of numerous stent grafts of various combinations of differently sized tubular bodies and branches, wherein the former requires significantly less warehousing cost than the latter.

Implantable or insertable medical devices for controlled drug delivery

Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device. Methods for manufacturing implantable or insertable medical devices are also provided.

STENT GRAFT WITH TWO LAYER ePTFE LAYER SYSTEM WITH HIGH PLASTICITY AND HIGH RIGIDITY

A vascular prosthesis and method are disclosed comprising a first flexible stent having a lattice structure with a compacted configuration and an expanded configuration, a second flexible stent inside the first flexible stent to form a tubular structure, a first film layer of graft material such as expanded polytetrafluoroethylene sandwiched between the first and second flexible stents, and a second film layer of expanded polytetrafluoroethylene sandwiched between the first and second flexible stents, the second layer having a higher rigidity and a lower plasticity than the first layer.

Defferential dilation stent and method of use

Embodiments herein provide differential dilation stents for use in percutaneous interventions, such as transluminal bypass procedures. In some embodiments, the stents may be used in the process of creating an arteriovenous (AV) fistula during a percutaneous bypass procedure, and such stents may have two or more specialized regions that are configured to adopt a predetermined diameter, shape, and/or tensile strength upon insertion in order to suit the needs of the vessel or procedure. The disclosed stents may be used for creating and/or maintaining an arterial/venous fistula for bypass of an occlusion in a cardiac artery using a cardiac vein, or the femoral artery, for example using the tibial or popliteal vein.

Helical hybrid stent

An expandable helical stent is provided, wherein the stent may be formed of an amorphous metal alloy or other non-amorphous metal with a securement. The stent is formed from flat or tubular metal in a helical coiled structure which has an undulating pattern. The main stent component may be formed of a single helically coiled component. Alternatively, a plurality of helically coiled ribbons may be used to form a stent heterogeneous in design, material, or other characteristic particular to that stent. The helical tubular structure may be secured with a securement, such as a weld, interlock or a polymer, to maintain the helical coils in a tubular configuration. The helical coils of the main stent component may be spaced apart or nestled to each other to maintain the tubular shape of the helically coiled stent and prevent the polymer layer from sagging at any point between cycles of the coils.

Arteriovenous Shunt Having a Flow Control Mechanism

An arteriovenous shunt assembly including a shunt and a pull wire operated flow control mechanism. The shunt has a tubular body that defines a fluid passageway between a first end and a second end thereof The pull wire mechanism includes a portion disposed around the tubular shunt in at least one loop. The at least one loop may be selectively tightened or loosened remotely from the shunt to regulate the rate of blood flow through the tubular shunt.

Debranching Great Vessel Stent Graft and Methods for Use

A debranching Great vessel stent graft and methods for its use, where the stent graft comprises, a main body stent graft with a first bifurcation defining a first leg and a second leg, the main body stent graft has distal and proximal ends, the main body stent graft has a diameter at the proximal end in the range from about 18 mm to about 28 mm, the first leg and the second leg each have a diameter in the range from about 12 mm to about 18 mm, the distance from the proximal end of the main body to the distal end of the first leg is in the range from about 30 mm to about 50 mm, and the distance from the proximal end of the main body to the distal end of the second leg is in a range from about 50 mm to about 70 mm.

Stent graft

A stent-graft including an inner stent having a wall structure including juxtaposed strut-patterns with interconnected struts and connectors connecting the strut-patterns is described. The wall structure of the inner stent has a predetermined length. An outer stent is coaxially arranged around the inner stent and has a wall structure including juxtaposed strut-patterns with interconnected struts and connectors connecting the strut-patterns. The wall structure of the outer stent has a predetermined length and a flexible stretchable material layer arranged between the inner stent and the outer stent. The wall structure of the inner stent has a design differing from the design of the wall structure of the outer stent and the length of the inner stent is equal to the length of the outer stent.

Methods for Making an Encapsulated Stent

A method for making an encapsulated stent includes providing first and second ePTFE layers and a stent positioned therebetween. The first ePTFE layer may be unsintered and have a node-fibril microstructure in which the fibrils are oriented perpendicular to the longitudinal axis. The second ePTFE layer may be unsintered and have a node-fibril microstructure in which the fibrils are oriented parallel to the longitudinal axis. The method includes joining the first ePTFE layer to the second ePTFE layer through openings in a wall of the stent.

THIN FILM VASCULAR STENT FOR ARTERIAL DISEASE

A thin film nitinol stent cover is provided that includes a plurality of fenestrations. Each fenestration extends in both longitudinal and transverse dimension, wherein the longitudinal and transverse dimensions are both less than or equal to a critical dimension that inhibits muscle cell migration through the fenestrations. 1. An implant for treating peripheral arterial disease , comprising:a plurality of stent struts; anda micro-patterned-thin-film (MTFN) nickel titanium (NiTi) stent cover configured to be positioned circumferentially around the plurality of stent struts, the stent cover including a plurality of fenestrations;wherein the fenestrations are sized to be small enough to substantially inhibit abluminal migration through the fenestrations.2. An implant as recited in claim 1 , wherein the fenestrations are sized to be large enough to allow for intercellular communication through the sheet.3. An implant as recited in claim 2 , wherein the MTFN stent cover extends in a longitudinal dimension claim 2 , and wherein the fenestrations are sized to have a maximum longitudinal dimension of 10 μm or less claim 2 , and wherein the fenestrations are sized to have a maximum transverse dimension of 10 μm or less.4. An implant as recited in claim 2 , wherein the longitudinal and transverse dimensions for the fenestrations are between approximately 5 μm and 10 μm.5. An implant as recited in claim 1 , wherein the MTFN stent cover has a thickness of less than approximately 50 μm.6. An implant as recited in claim 5 , wherein the MTFN stent cover has a thickness of less than approximately 10 μm.7. An implant as recited in claim 6 , wherein the MTFN stent cover has a thickness ranging between approximately 5 μm and 10 μm.8. An implant as recited in claim 1 , wherein the MTFN stent cover comprises at least one hydrophilic surface having a water contact angle of approximately 40 degrees or less.9. An implant as recited in claim 8 , wherein the MTFN stent cover comprises at ...

PERSONALIZED PROSTHESIS AND METHODS OF USE

A personalized prosthesis for implantation at a treatment site of a patient includes a self-expanding mesh or membrane having collapsed and expanded configurations. The collapsed configuration is adapted to be delivered to the treatment site, and the expanded configuration engages the personalized prosthesis with the treatment site. The mesh or membrane is personalized to match the treatment site in the expanded configuration, and has an outer surface that substantially matches the treatment site shape and size. The self-expanding mesh or membrane forms a central lumen configured to allow blood or other body fluids to flow therethrough. Methods of manufacturing and delivery of the personalized prosthesis are also disclosed. 1. A personalized prosthesis , said prosthesis comprising:A radially expandable prosthesis, wherein the prosthesis is personalized prior to implantation thereof such that the prosthesis substantially matches a shape and a volume of a treatment site.2. A method of treating a treatment site , said method comprising:providing a personalized prosthesis;delivering the prosthesis to the treatment site; andradially expanding the prosthesis into engagement with the treatment site such that the prosthesis substantially matches a shape and a volume of the treatment site. The present application is a continuation of U.S. patent application Ser. No. 15/628,431 (Attorney Docket No. 44600-703.302) now U.S. Pat. No. filed Jun. 20, 2017 which is a continuation of U.S. patent application Ser. No. 14/850,586 (Attorney Docket No. 44600-703.401) now U.S. Pat. No. 9,744,060 filed Sep. 10, 2015 which is a divisional application of U.S. patent application Ser. No. 13/663,160 (Attorney Docket No. 44600-703.201, formerly 45045-703.201) filed Oct. 29, 2012 now abandoned, which is a non-provisional of and claims the benefit of U.S. Provisional Patent Application No. 61/554,099 (Attorney Docket No. 44600-703.101, formerly 45045-703.101) filed Nov. 1, 2011; the entire ...

ENDOGRAFT VISUALIZATION WITH PRE-INTEGRATED OR REMOVABLE OPTICAL SHAPE SENSING ATTACHMENTS

An endograft () includes a stent structure. An optical shape sensing (OSS) system () is associated with the endograft and is configured to measure shape, position and/or orientation of the stent structure. The OSS system () is connected to the stent structure and removable in a plurality of ways. Methods for deployment and removal of the OSS system are also provided. 1. An endograft , comprising:a stent structure;at least one attachment mechanism configured to releasably attach to the stent structure; andat least one optical shape sensing (OSS) system having one or more optical fibers, wherein said optical shape sensing system is coupled to the at least one attachment mechanism and is configured to measure at least one of shape, position or orientation of the stent structure.2. The endograft as recited in claim 1 , wherein the at least one attachment mechanism includes a hook claim 1 , a clip claim 1 , a clamp claim 1 , a magnet and a capture tube.3. The endograft as recited in claim 1 , wherein the at least one attachment mechanism is coupled at a distal end of the at least one OSS system.4. The endograft as recited in claim 1 , wherein the at least one attachment mechanism attached to the stent structure at attachment point of a geometric landmark.5. The endograft as recited in claim 4 , wherein the attachment point includes one or more of a ring of the endograft claim 4 , a fenestration claim 4 , a scallop or a bifurcation junction.6. The endograft as recited in claim 1 , wherein the at least one attachment mechanism is selectively releasable from the stent structure.7. The endograft as recited in claim 1 , wherein the at least one attachment mechanism includes a plurality of attachment points on the stent structure for a same OSS system.8. An endograft claim 1 , comprising:a stent structure;at least one deployable instrument pre-cannulated through a fenestration in the stent structure; andthe at least one deployable instrument including an optical shape sensing ...

LAYERED MEDICAL APPLIANCES AND METHODS

Medical appliances may be formed of multilayered constructs. The layers of the constructs may be configured with various physical properties or characteristics. The disposition and arrangement of each layer may be configured to create an overall construct with a combination of the individual properties of the layers. Constructs may be used to create vascular prostheses or other medical devices. 1. (canceled)3. The multilayered vascular prosthesis of claim 2 , wherein the axis of longitudinal expansion of at least one of the ePTFE sublayers is disposed at an angle between 0 degrees and 90 degrees to the axis of longitudinal expansion of at least one adjacent ePTFE sublayer.4. The multilayered vascular prosthesis of claim 2 , wherein the axis of longitudinal expansion of at least one of the ePTFE sublayers is perpendicular to the axis of longitudinal expansion of at least one adjacent ePTFE sublayer.5. The multilayered vascular prosthesis of claim 2 , wherein the axis of longitudinal expansion of at least one of the ePTFE sublayers is at an angle to a longitudinal axis of the multilayered vascular prosthesis.6. The multilayered vascular prosthesis of claim 2 , wherein at least one of the ePTFE sublayers is configured to be impermeable to red blood cell migration.7. The multilayered vascular prosthesis of claim 6 , wherein an average pore size of at least one of the ePTFE sublayers is different than an average pore size of at least one adjacent ePTFE sublayer.8. The multilayered vascular prosthesis of claim 6 , wherein pores of at least one of the ePTFE sublayers are misaligned with pores of at least one adjacent ePTFE sublayer such that a tortuous path is defined between the pores of the sublayers.9. The multilayered vascular prosthesis of claim 6 , wherein at least one of the ePTFE sublayers is coupled to a non-porous layer.10. A multilayered vascular prosthesis claim 6 , comprising:a luminal surface comprising a serially deposited fiber layer; andan expanded ...

Implantable graft and methods of making same

The present invention relates to an implantable endoluminal graft comprised of a microporous thin-film metal covering having a plurality of openings and a structural support element underlying and physically attached to the microporous thin-film metal covering, the microporous thin-film metal covering having shape memory properties.

Bridging Stent Graft with Interlocking Features and Methods for Use

The present disclosure provides a stent graft comprising (a) a self-expandable stent structure and a graft covering positioned over the self-expandable stent structure, the self-expandable stent structure having a first end and a second end, wherein the self-expandable stent structure defines a lumen, and (b) at least one annular channel defined by at least one of the self-expandable stent structure and the graft covering and extending radially outward from the self-expandable stent structure or at least one annular protrusion defined by at least one of the self-expandable stent structure and the graft covering and extending radially inward from the self-expandable stent structure. 1. A stent graft , comprising:a self-expandable stent structure and a graft covering positioned over the self-expandable stent structure, the self-expandable stent structure having a first end and a second end, wherein the self-expandable stent structure defines a lumen; andat least one annular channel defined by at least one of the self-expandable stent structure and the graft covering and extending radially outward from the self-expandable stent structure or at least one annular protrusion defined by at least one of the self-expandable stent structure and the graft covering and extending radially inward from the self-expandable stent structure.2. The stent graft of claim 1 , wherein the lumen has a diameter ranging from about 4 mm to about 30 mm and a length ranging from about 20 mm to about 250 mm.3. The stent graft of claim 1 , wherein the graft covering extends about 2 mm to about 3 mm past the second end of the self-expandable stent structure.4. The stent graft of claim 1 , wherein the second end of the self-expandable stent structure comprises a plurality of extensions biased radially outward.5. The stent graft of claim 4 , wherein the plurality of extensions are at least about 5 mm in length.6. The stent graft of claim 4 , wherein the plurality of extensions comprise a plurality ...

Drug-Impregnated Encasement

A drug-impregnated sleeve for encasing a medical implant is provided. In one embodiment, the sleeve may include a body made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet of a biologically-compatible material. 1a body made of a biologically-compatible material and defining an internal cavity configured to receive a medical implant, the body including a plurality of apertures extending from the cavity through the body;a first end;a second end; anda drug impregnated into the material. A biologically-compatible sleeve comprising: The present invention relates to an improved drug-impregnated encasement that is configured and adapted to receive a medical implant, and more particularly to a sleeve in one embodiment that is operative to encase orthopedic implants of varying types, sizes, and shapes for delivering a drug to the implantation site.Colonization of bacteria on the surface of implants often leads to infections. Systemic antibiotics can reduce the risk of infection; however infections can still develop on the surface of implants even in the presence of systemic prophylactic antibiotics. It is not uncommon for orthopedic surgeons to treat implant sites with local antibiotics or other biologically active agents. In sonic cases the ...

ENDOLUMINAL PROSTHESIS HAVING MULTIPLE BRANCHES OR FENESTRATIONS AND METHODS OF DEPLOYMENT

A system for facilitating deployment of an endoluminal prosthesis may include a main tubular graft body including a proximal end opening, a distal end opening, a lumen, and a sidewall. A branch may extend from the sidewall and may include a first end opening, a second end opening, and a lumen. A fenestration may be disposed in the sidewall and positioned distal of the second end opening of the branch. A wire segment may include a proximal portion positioned proximal of the proximal end opening and a distal portion positioned distal of the distal end opening. The wire segment extend through the fenestration and through the lumen of the branch in a preloaded configuration. 1. A branched prosthesis comprising:a tubular body of biocompatible graft material having a proximal end, a distal end, an internal lumen, and a longitudinal axis from the proximal end to the distal end;a proximal portion having a first diameter;a distal portion having a second diameter less than the first diameter;a tapered portion between the proximal portion and the distal portion;a retrograde portal at least partially disposed in the distal portion having an opening and configured to permit retrograde fluid flow therethrough;at least two antegrade portals at least partially disposed in the proximal portion each having an open end extending toward the distal end and configured to permit antegrade fluid flow therethrough.2. The prosthesis of claim 1 , wherein the retrograde portal and the at least two antegrade portals are configured to receive a branch extension.3. The prosthesis of claim 1 , wherein one or more radiopaque markers is positioned proximate to one or more of the portals to facilitate imaging of the one or more portals.4. The prosthesis of claim 2 , wherein the branch extensions are balloon expandable.5. The prosthesis of claim 5 , wherein the branch extensions are covered balloon expandable stents.6. The prosthesis of claim 1 , wherein the open ends of the antegrade portals are ...

GRAFT DIMPLING TO IMPROVE CRIMP PROFILE AND REDUCE DELIVERY FORCES

A stent-graft assembly is provided for a variety of medical treatments. The stent-graft assembly includes a stent disposed to and attached between an inner layer of graft material and an outer layer of graft material. One of both of the graft layers includes one or more of a depression, dimple or detent that increases the localized surface area of the graft in one or more portions of the stent otherwise susceptible to graft stretching in the absence of the depression, dimple or detent. There is also described a method of forming dimples in selective locations on one or port graft layers in one or more locations relative to a portion of the stent where a portion of the graft may be susceptible to stretching or tearing during crimping or loading operations. 1. A stent graft assembly , comprising:a stent structure comprising a luminal surface and an abluminal surface and having at least a first radial opening and a second radial opening, said first and second radial openings extending through said stent structure between said luminal surface and said abluminal surface, wherein said first and second radial openings are spaced apart along a first direction;a first graft layer having a first thickness disposed along and covering said luminal surface of said stent structure;a second graft layer having a second thickness disposed along and covering a portion of said abluminal surface of said stent structure;one or more dimples formed in the first graft layer and the second graft layer positioned with respect to the stent structure to form a dimple zone of localized additional material.2. The stent graft assembly of wherein the one or more dimples are formed so as to from a protrusion in a portion of the graft layer.3. The stent graft assembly of wherein the one or more dimples are formed so as to form a protrusion in a portion of the second graft layer.4. The stent graft assembly of wherein the dimple zone of localized additional material is selected to accommodate ...

FLEXIBLE STENT WITH NON-BONDED STENT COVER MATERIAL REGIONS

A prosthesis is provided for a variety of medical treatments. The prosthesis may include an expandable tubular frame structure and a covering disposed along the frame structure. A proximal liner may be situated along a proximal end of the frame, a distal liner may be situated along a distal end of the frame, and an intermediate liner may be between the proximal liner and the distal liner along the frame. The intermediate liner comprises an extended layer that meets and bonds to the proximal liner and the distal liner at their respective ends. A method of manufacturing the prosthesis is also provided. 1. A prosthesis comprising:an expandable tubular frame structure having a proximal frame end and a distal frame end;a covering disposed along the frame structure, the covering including a first liner, a proximal liner, and a distal liner discrete from the proximal liner, the first liner comprising a plurality of first liner layers, wherein at least one of the first liner layers is an extended layer extending beyond a proximal end of the remaining first liner layers and a distal end of the remaining first liner layers of the first liner,wherein a proximal end of the extended layer is bonded to the proximal liner along the proximal frame end at a first coupling segment, and a distal end of the extended layer is bonded to the distal liner along the distal frame end at a second coupling segment, andwherein one of the first liner layers immediately adjacent to the expandable tubular frame structure remains unbonded to the expandable tubular frame structure along an intermediate region of the frame structure disposed between the proximal and distal frame ends.2. The prosthesis of claim 1 , wherein the first and second coupling segments have a common wall thickness claim 1 , and an intermediate segment of the first liner that remains unbonded to the expandable tubular frame structure comprises a wall thickness sized the same as the common wall thickness.3. The prosthesis of ...

Method of making implantable medical devices having controlled surface properties

An implantable medical device that is fabricated from materials that present a blood or body fluid or tissue contact surface that has controlled heterogeneities in material constitution. An endoluminal stent-graft and web-stent that is made of a monolithic material formed into differentiated regions defining structural members and web regions extending across interstitial spaces between the structural members. The endoluminal stent-graft is characterized by having controlled heterogeneities at the blood flow surface of the stent.

METHODS OF MAKING A PROSTHESIS WITH A SMOOTH COVERING

The present invention relates to methods of making a prosthesis or a stent with a smooth covering. The method includes providing an elastomeric tube including an inner diameter and an outer diameter, positioning the elastomeric tube in a tube expander including a vacuum, expanding the inner diameter and the outer diameters of the elastomeric tube by applying the vacuum, providing a mandrel, positioning an inner covering over the mandrel, positioning a stent over the inner covering, positioning an outer covering over the stent to form a covered stent, positioning the mandrel and the covered stent in the tube expander, releasing the vacuum, removing the elastomeric tube, the covered stent, and the mandrel form the tube expander, applying pressure and heat to the elastomeric tube, the covered stent, and the mandrel, removing the elastomeric tube, the covered stent, and the mandrel from the pressure and the heat, removing the elastomeric tube from the covered stent, and removing the mandrel from the covered stent. 1. A method of making a stent with a smooth covering , said method comprising:positioning an elastomeric tube comprising an inner diameter and an outer diameter in a tube expander comprising a vacuum;expanding the inner diameter and the outer diameter of the elastomeric tube by applying the vacuum;positioning an inner covering over a mandrel;positioning a stent over the inner covering;positioning an outer covering over the stent to form a covered stent;positioning the mandrel and the covered stent in the tube expander;releasing the vacuum;removing the elastomeric tube, the covered stent, and the mandrel form the tube expander;applying pressure and heat to the elastomeric tube, the covered stent, and the mandrel;removing the elastomeric tube, the covered stent, and the mandrel from the pressure and the heat;removing the elastomeric tube from the covered stent; andremoving the mandrel from the covered stent.2. The method of claim 1 , wherein the inner covering ...

Rotational spun material covered medical appliances and methods of manufacture

A medical appliance or prosthesis may comprise one or more layers of rotational spun nanofibers, including rotational spun polymers. The rotational spun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Rotational spun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis. Additionally, one or more cuffs may be configured to allow tissue ingrowth to anchor the prosthesis.

Drug-impregnated encasement

A drug-impregnated sleeve for encasing a medical implant is provided. In one embodiment, the sleeve may include a body made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet of a biologically-compatible material.

ELECTROSPUN PTFE COATED STENT AND METHOD OF USE

A stent or other prosthesis may be formed by coating a single continuous wire scaffold with a polymer coating. The polymer coating may consist of layers of electrospun polytetrafluoroethylene (PTFE). Electrospun PTFE of certain porosities may permit endothelial cell growth within the prosthesis. 1. A covered stent , comprising:a scaffolding structure comprising a midsection and an end section,wherein a compressibility of the first end section is greater than a compressibility of the midsection; and an inner layer of electrospun polytetrafluoroethylene (PTFE);', 'an outer layer of electrospun PTFE; and', 'a tie layer disposed between the inner layer and the outer layer,', 'wherein the scaffolding structure is disposed between the inner layer and the outer layer., 'a cover coupled to the scaffolding structure, comprising2. The covered stent of claim 1 ,wherein the midsection comprises a first plurality of apexes and the end section comprises a second plurality of apexes, andwherein a first apex distance between each apex of the first plurality of apexes is less than a second apex distance between each apex of the second plurality of apexes.4. The covered stent of claim 3 , wherein one or more of the first apex distance claim 3 , the second apex distance claim 3 , and the third apex distance incrementally increases from a longitudinal midpoint of the scaffolding structure toward ends of the scaffolding structure.5. The covered stent of claim 3 ,wherein each of the first plurality of apexes is nested within an adjacent apex of the first plurality of apexes; andwherein each of the second plurality of apexes and third plurality of apexes is non-nested relative to an adjacent apex of the second plurality of apexes and third plurality of apexes.6. The covered stent of claim 1 ,wherein the midsection comprises a first plurality of arms and the end section comprises a second plurality of arms; andwherein a first arm length of each of the first plurality of arms is less than a ...

Atraumatic gastrointestinal anchor

The present invention relates to methods and articles for anchoring within a natural bodily lumen. An anchor is adapted to provide differing radially-outward forces along its length, a securing force and a transitional force. Production of these forces can be controlled by varying a physical property of the anchor, such as its stiffness, thickness, or shape. For example, the stiffness of an elongated anchor can be varied from a relatively soft value at its proximal and distal ends to a relatively stiff value at its center by varying the diameter of wire forming the anchor, thereby tailoring it to an intended application. Such force tailoring can be combined with external barbs and used to reliably anchor other instruments, such as feeding tubes and intestinal sleeves.

STENT DEVICE HAVING REDUCED FORESHORTENING AND RECOIL AND METHOD OF MAKING SAME

A stent device includes generally cylindrical rings aligned along a longitudinal axis, and interconnected by interconnecting members. Each interconnecting member includes a first coupling end, a second coupling end, and an elongate portion therebetween. The first coupling end, the elongate portion, and the second coupling end combine in either a first orientation or a second orientation, which are substantially mirror images. For each interconnecting member, the first coupling end can intersect with a midpoint of a transition region of a substantially repeating curved segment on one of the rings, and the second coupling end can intersect with a midpoint of a curved segment of a different and immediately adjacent ring. The interconnecting members can be arranged in rows extending longitudinally along the device. Along each row, consecutive interconnected members alternate between the first orientation and the second orientation. A cover may be provided over the stent device. 126-. (canceled)27. A method of manufacturing a stent device , the method comprising:providing a plurality of generally cylindrical rings each formed by a plurality of substantially repeating bent segments, each of the plurality of bent segments comprising one substantial peak, one substantial valley, and a transition region leading between the one substantial peak and the one substantial valley, each bent segment having a midpoint on the transition region substantially midway between the one substantial peak and the one substantial valley, the plurality of rings being arranged in a series along a longitudinal axis in such a way that the one substantial peak and the one substantial valley of each bent segment of each ring in the series is substantially a mirror image of one substantial peak and one substantial valley of a corresponding curved segment in an immediately adjacent ring; and a first coupling end;', 'a second coupling end opposite the first coupling end; and', 'an elongate portion ...

External support for elongated bodily vessels

External support implant for unbound covering of a blood vessel graft in a peripheral vascular bypass system. The implant includes: elongate body having a longitudinal axis, and interior collapsible upon exterior of the blood vessel graft. Elongate body includes tubular fabric having intertwined coiled compression springs configured for elastically resisting longitudinal compression of the elongate body from a relaxed length, when compression springs are slightly stressed, and for elastically increasing diameter of the elongate body when compression springs are subjected to the longitudinal compression.

SYSTEM AND METHOD FOR SCAFFOLDING OF ANASTOMOSES

Embodiments of the invention provide systems and methods for using a tissue scaffold to facilitate healing of an anastomosis. One embodiment provides a tissue scaffold for placement at an anastomotic site within a body lumen comprising a radially expandable scaffold structure having lateral and mid portions, at least one retention element coupled to each lateral portion and a barrier layer. The retention element engages a luminal wall when the scaffold structure is expanded to retain the structure and exert a compressive force on the anastomosis. The mid portion has a greater radial stiffness than the lateral portions such that when the structure is expanded, the lateral portions engage tissue prior to the mid portion. The barrier layer is configured to engage a luminal wall when the structure is expanded to provide a fluidic seal at the anastomosis. The barrier layer may also include releasable biological agents to promote anastomotic healing. 1. A method for healing of an anastomosis in a target body lumen , the method comprising:positioning a prosthetic scaffold at an anastomotic site in the target body lumen;radially expanding the prosthetic scaffold to engage a wall of the target body lumen;utilizing the prosthetic scaffold to apply a compressive force on the wall of the target body lumen to maintain opposing like tissue layers of the anastomosis in substantial alignment; andretaining the prosthetic scaffold at the anastomotic site during a period of anastomotic healing.2. The method of claim 1 , wherein the prosthetic scaffold includes a barrier layer claim 1 , the method further comprising:engaging the barrier layer with the wall of the target body lumen to form a fluidic seal between the anastomosis and the barrier layer.3. The method of claim 1 , wherein the prosthetic scaffold includes a biological agent claim 1 , the method further comprising:delivering the biological agent to the anastomotic site to facilitate healing of the anastomosis.4. The method of ...

INTRALUMINAL VASCULAR PROSTHESIS

The invention relates to an intraluminal vascular prosthesis, preferably for implanting in the aortic arch. The prosthesis has a hollow cylindrical body with a first end and a second end; a first vascular prosthesis portion; a second vascular prosthesis portion; and a stent portion which is provided between the first and the second vascular prosthesis portion and which is rigidly connected to said vascular prosthesis portions, said stent portion being free of prosthesis material. 2. The intraluminal vascular prosthesis as claimed in claim 1 , wherein the first vascular prosthesis portion and the second vascular prosthesis portion are designed for anchoring the vascular prosthesis in the aorta.3. The intraluminal vascular prosthesis as claimed in claim 1 , wherein the first vascular prosthesis portion has a self-expanding material.4. The intraluminal vascular prosthesis as claimed in claim 1 , wherein the first vascular prosthesis portion has between two and five rings of successive meandering supports.5. The intraluminal vascular prosthesis as claimed in claim 1 , wherein the first vascular prosthesis portion has three successive rings of meandering supports claim 1 , which are connected to one another by the prosthesis material.6. The intraluminal vascular prosthesis as claimed in claim 1 , wherein the stent portion free of prosthesis material has a braided or twisted wire braid.7. The intraluminal vascular prosthesis as claimed in claim 1 , wherein the stent portion free of prosthesis material is a laser-cut tube.8. A method for releasing the intraluminal vascular prosthesis as claimed in claim 1 , wherein the method has the following consecutive steps:introducing the intraluminal vascular prosthesis in the compressed state into an aorta of a patient, in such a way that the whole of the first vascular prosthesis portion is positioned in the distal direction in relation to the subclavian artery;transferring the intraluminal vascular prosthesis to the expanded state ...

Grafts and Stent Grafts Having a Radiopaque Marker

A graft device comprising a layer of synthetic non-metallic material having a first surface and a second surface spaced apart from the first surface. The device further includes a radiopaque marker at least partially embedded in the layer.

STENT GRAFT HAVING MOVABLE FENESTRATED TUBULAR BRIDGE

A stent graft comprising an elongate main tubular body of a biocompatible graft material is disclosed. The main tubular body comprises a main lumen, a distal end and a proximal end; and an elongate tubular bridge of a biocompatible graft material. The elongate tubular bridge extends around a portion of the main tubular body so as to form a bridging lumen bridging between two circumferentially spaced-apart openings within the main tubular body. The tubular bridge has at least two fenestrations. The tubular bridge comprises concertinaed graft material. 1. A stent graft comprising:an elongate main tubular body of a biocompatible graft material, the main tubular body comprising a main lumen, a distal end and a proximal end; andan elongate tubular bridge of a biocompatible graft material, the elongate tubular bridge extending around a portion of the main tubular body and forming a bridging lumen bridging between two circumferentially spaced-apart openings within the main tubular body, the tubular bridge comprising at least two fenestrations.2. The stent graft as claimed in wherein the tubular bridge comprises concertinaed graft material.3. The stent graft as claimed in wherein the concertinaed graft material comprises a plurality of circumferential crimps.4. The stent graft as claimed in wherein a first sub-set of the circumferential crimps project outwards radially.5. The stent graft as claimed in wherein a second sub-set of the circumferential crimps project inwards radially.6. The stent graft as claimed in wherein the tubular bridge comprises at least three fenestrations.7. The stent graft as claimed in wherein the tubular bridge comprises first and second end portions joined by an intermediate portion claim 1 , the first and second end portions located within the main tubular body.8. The stent graft as claimed in wherein the first end portion terminates in an opening claim 7 , the opening comprising a reinforcing end ring.9. The stent graft as claimed in wherein the ...

ENDOLEAK ISOLATION SLEEVES AND METHODS OF USE

Devices and methods for reducing or eliminating endoleaks by isolating feeder vessels from an aneurysm of a patient. In some cases, a tubular isolation sleeve may be deployed in a patient's aneurysm prior to deployment of an endograft such as a modular bifurcated endograft. 1. A self-expanding tubular isolation sleeve for treatment of an aneurysm and reduction of endoleaks , comprising:a self-expanding resilient frame including one or more resilient strands formed into a tubular structure that is configured to expand from a radially constrained state to a radially expanded state and conform to an irregular morphology of an abdominal aortic aneurysm;at least one tubular layer of thin flexible sheet material disposed on the resilient frame which has an outside surface that is configured to seal against an inner wall of an aneurysm and isolate a feeder vessel of the aneurysm; anda fusiform configuration wherein an outer profile of the tubular isolation sleeve in a relaxed unconstrained state is configured to roughly approximate a profile of an interior surface of a typical abdominal aortic aneurysm and wherein the outer profile includes a proximal reduced transverse dimension section at a proximal end thereof, a distal reduced transverse dimension section at a distal end thereof and an enlarged center section of greater transverse dimension than the proximal and distal reduced transverse dimension sections.24. The tubular isolation sleeve of wherein the enlarged center section has a transverse dimension up to about times the transverse dimension of the proximal reduced diameter section and the distal reduced diameter section.3. The tubular isolation sleeve of wherein the enlarged center section has a transverse dimension that is about 1.4 times to about 3 times the transverse dimension of proximal reduced diameter section and the distal reduced diameter section.4. The tubular isolation sleeve of wherein an axial length of the tubular isolation sleeve is about 8 cm to ...

STENT TO BE PLACED IN BILE DUCT AND PROCESS FOR PRODUCING SAME

Provided are a stent to be placed in the bile duct and a process for producing the stent, the stent hollow being less apt to be blocked even when the stent is placed in the bile duct for a long period. The inner peripheral surface of the stent is coated with a resin layer with resistance to sludge formation that includes a polymer obtained by polymerizing 2-methoxyethyl acrylate. This stent is produced by applying a coating fluid that contains 0.1-0.5 mass % polymer obtained by polymerizing 2-methoxyethyl acrylate, to the inner peripheral surface of a stent. 1. A stent to be placed in bile duct providedas a stent body of a cylindrical metal mesh tube and a cover member covering the outer periphery and/or inner periphery of the stent body, oras a cylindrical resin tube,wherein the inner peripheral surface of the stent is covered by a sludge-resistant resin layer formed by coating a coating liquid containing 0.1 to 0.5 mass % of a polymer obtained through polymerization of 2-methoxyethyl acrylate.2. The stent to be placed in bile duct of claim 1 ,wherein the sludge-resistant resin layer has a contact angle to water of 32° or less at a temperature of 22° C.3. The stent to be placed in bile duct of claim 1 ,wherein the cover member includes a polyurethane film covering the stent body and a silicone film covering the stent body and the outer periphery of the polyurethane film, andwherein the sludge-resistant resin layer is formed on the inner periphery of the polyurethane film of the cover member.4. The stent to be placed in bile duct of claim 1 ,wherein the sludge-resistant resin layer is formed by coating the coating liquid containing 0.1 to 0.2 mass % of the polymer obtained through polymerization of 2-methoxyethyl acrylate on the inner peripheral surface of the stent.5. The stent to be placed in bile duct of claim 1 ,wherein concaves and convexes are formed on the outer peripheral surface of the stent.6. A method for producing a stent to be placed in bile duct claim ...

DIAMETRICALLY ADJUSTABLE ENDOPROSTHESES AND ASSOCIATED SYSTEMS AND METHODS

A diametrically adjustable endoprosthesis includes a controlled expansion element extending along at least a portion of a graft and is supported by a stent. The controlled expansion element diametrically constrains and limits expansion of the endoprosthesis. Upon deployment from a smaller, delivery configuration, the endoprosthesis can expand to the initial diameter set by the controlled expansion element. Thereafter, the endoprosthesis can be further diametrically expanded (e.g., using balloon dilation) by mechanically altering the controlled expansion element. 1. A diametrically adjustable endoprosthesis comprising:a stent-graft including a stent and a base graft secured to the stent, the base graft having a first end and a second end and the stent-graft being self-expanding and exhibiting a self-expansion force, the stent-graft having a maximum diametric expansion limit; anda controlled expansion element having a continuous wall, the controlled expansion element having an initial diametric expansion limit and being adjustable to an adjusted diameter in a range of diameters between the initial diametric expansion limit and the maximum diametric expansion limit when placed under an expansion force in addition to the self-expansion force of the stent-graft, the controlled expansion element being configured to maintain the adjusted diameter under physiological conditions following removal of the expansion force and the stent-graft being configured to limit the range of diameters for the adjusted diameter to the maximum diametric expansion limit.2. The endoprosthesis of claim 1 , wherein the controlled expansion element defines a sliding interface with the stent-graft such that during diametric expansion of the endoprosthesis claim 1 , the sliding interface between the controlled expansion element and the stent-graft permits at least a portion of the controlled expansion element to change in longitudinal dimension at a different rate than the stent-graft at the ...

COMPOSITE PROSTHETIC DEVICES

The present disclosure provides composite prosthetic devices comprising two or more layers of electrospun polymers and methods of preparation thereof. In some embodiments, the two or more layers can be porous and in other embodiments, one or more components is nonporous. The composite prosthetic devices can comprise various materials and the properties of the prosthetic devices can be tailored for use in a range of different applications. 120-. (canceled)21. A method for producing a composite prosthetic device comprising:combining at least one porous layer comprising electrospun poly(tetrafluoroethylene) and at least one porous layer comprising a second electrospun polymer to give a composite prosthetic device precursor; andapplying pressure, heat, or both pressure and heat to the composite prosthetic device precursor to provide a composite prosthetic device.22. The method of claim 21 , further comprising placing a structural frame around the porous layer comprising electrospun poly(tetrafluoroethylene).23. The method of claim 22 , wherein the structural frame is a stent.24. The method of claim 22 , wherein the structural frame comprises open spaces through which the second electrospun polymer penetrates.25. The method of claim 21 , wherein the combining comprises wrapping the porous layer comprising a second electrospun polymer around the porous layer comprising electrospun poly(tetrafluoroethylene).26. The method of claim 21 , wherein the combining comprises electrospinning the porous layer comprising a second electrospun polymer onto the porous layer comprising electrospun poly(tetrafluoroethylene).27. The method of claim 21 , wherein the second electro spun polymer comprises a solution-electrospun polymer.28. The method of claim 21 , wherein the second electrospun polymer comprises a thermoplastic polymer or a thermoset polymer.29. The method of claim 21 , wherein the second electrospun polymer layer comprises a polyurethane or a silicone.30. The method of claim ...

VASCULAR GRAFTS WITH MULTIPLE CHANNELS AND METHODS FOR MAKING

A wall, for example the wall of a vascular graft, has multiple channels within it. The channels may be used to hold drugs or reinforcing fibers. The channels may have a predetermined roughness. The channels may be formed by coextrusion using a soluble material, for example, to define the channels and then dissolving them to open the channels in the extrudate. 1. A medical device comprising:billet-A having a first billet-A material surrounding a first array of helical channels having a first handedness;billet-B having a first billet-B material surrounding a second array of helical channels having a second handedness that is opposite the first handedness and wherein Billet-B is disposed coaxial and inside of billet-A,wherein the first helical channels contain reinforcements and the second helical channels contain a drug.2. The medical device of wherein the interior roughness of a second helical channel is greater than 50 micrometers or greater than 100 micrometers.3. The medical device of wherein the first billet-B material is porous.4. The medical device of wherein the diameter of a second helical channel is greater than twice that of the largest pore.5. The medical device of further comprising a stent disposed between billet-A and billet-B.6. The medical device of wherein the drug is heat sensitive.7. The medical device of wherein the drug is inside of a non-drug material.8. The medical device of wherein the drug is impregnated in a drug-releasing fiber.9. The medical device of wherein the first billet-A material is not the same as the first billet-B material.10. The medical device of further comprising a longitudinal seam.11. The medical device of wherein the drug is heat sensitive.12. The medical device of wherein the drug is inside of a non-drug material.13. The medical device of wherein the drug is in a drug-releasing fiber.14. The medical device of wherein the first billet-A material is not the same as the first billet-B material.15. The medical device of ...

AORTIC INSUFFICIENCY REPAIR DEVICE AND METHOD

The present application concerns embodiments of methods, systems, and apparatus for treating aortic insufficiency. Disclosed methods, systems and apparatus can also be used to treat aortic root dilation. Certain embodiments include a percutaneous or minimally invasively implantable prosthetic device, such as a stented graft, that is configured to be implanted in the sinus of Valsalva (the aortic sinuses) and anchored within one or both of the coronary arteries. An expandable prosthetic heart valve can then be implanted in the previously implanted prosthetic device. In patients suffering from root dilation, another percutaneous or minimally invasively implantable graft can be implanted within the ascending aorta. 1. A method comprising:introducing a guidewire into a patient's body;advancing the guidewire until a distal end portion of the guidewire extends into the aortic root and into one of the coronary arteries;advancing a prosthetic device along the guidewire into the aortic root;aligning a side opening of the prosthetic device with the coronary artery into which the guidewire extends; andradially expanding the prosthetic device within the aortic root.2. The method of claim 1 , further comprising implanting a prosthetic valve within the prosthetic device.3. The method of claim 2 , wherein implanting the prosthetic valve within the prosthetic device comprises introducing the prosthetic valve into the patient's body on a catheter and radially expanding the prosthetic valve within the prosthetic device.4. The method of claim 1 , wherein the prosthetic device comprises prosthetic valve leaflets.5. The method of claim 1 , further comprising implanting a stented graft in the ascending aorta.6. The method of claim 5 , wherein an inflow end portion of the stented graft overlaps an outflow end portion of the prosthetic device.7. The method of claim 1 , wherein:the act of introducing a guidewire into a patient's body comprises introducing first and second guidewires into ...

DEVICES FOR FLUID FLOW THROUGH BODY PASSAGES

A device includes a first end portion, a second end portion, an intermediate portion between the first end portion and the second end portion, and a graft material coupled to at least the intermediate portion. The first end portion has a first end diameter. The second end portion has a second end diameter larger than the first end diameter. The intermediate portion tapers between the first end portion and the second end portion. A method of diverting fluid flow from a first passage to a second passage comprising deploying the device in a third passage between the first passage and the second passage, expanding the first end portion against sidewalls of the first passage, and expanding the second end portion against sidewalls of the second passage. 1. (canceled)2. A method of diverting fluid flow from a first vessel to a second vessel in a limb , the method comprising:inserting a first catheter in the first vessel;inserting a second catheter in the second vessel;deploying a needle from the first catheter, through tissue between the first vessel and the second vessel, and into the second vessel; and a first end portion having a first end diameter sized to correspond to a diameter of the first vessel,', 'a second end portion having a second end diameter sized to correspond to a diameter of the second vessel, and', 'an intermediate portion between the first end portion and the second end portion,, 'deploying a device in the first vessel, the second vessel, and the tissue between the first vessel and the second vessel, the device comprising expanding the first end portion coaxial with and against sidewalls of the first vessel, wherein expanding the first end portion comprises self-expanding the first end portion,', 'expanding the intermediate portion, wherein expanding the intermediate portion comprises self-expanding the intermediate portion, and', 'expanding the second end portion coaxial with and against sidewalls of the second vessel, wherein expanding the second end ...

Vascular Medical Device, System And Method

The present application discloses a covered stent and a method for navigating the covered stent to a branch vessel, the covered stent including a main body and at least one lateral side branch connected to the main body. A system of covered stents and a method for implanting, including interconnecting the covered stents is also disclosed. 1. A covered stent comprising:a main body,at least one branch, including one, two or three branches, connected to the main body, and characterized byat least one bendable and/or flexible guiding element being distally permanently or releasably attached to an interior of one of said at least one said branches at a connection point at a distal orifice of said branch, and said guiding element being proximally arranged in the interior, through and along a proximal portion of said main body and extending proximally through a proximal opening of the main body or through a leg of said covered stent, said guiding element being arranged to be received by a guiding mate of a delivery catheter for delivery of a further element such as a further covered stent to said one of said at least one said branches at said connection point, and said guiding element being configured for guiding said delivery catheter over said guiding element through said main body towards said distal orifice of said branch.2. The covered stent of claim 1 , including a fiducial marker at said connection point and/or at said distal orifice of said lateral side branch.3. The covered stent according to claim 1 , wherein the lateral side branch is laterally extendable and/or collapsible from or towards the main body.4. The covered stent according to claim 1 , wherein the side branch comprises a covered stent claim 1 , wherein the lateral side branch is integral with the main body claim 1 , and a stent portion of said covered stent is a spring claim 1 , such as a helically coiled wire claim 1 , elastically self deploying in the longitudinal direction of the side branch ...

Side branch stent graft

A joining arrangement between a main tube ( 3 ) and a side arm ( 5 ) in a side arm stent graft ( 1 ). The side arm ( 5 ) is stitched into an aperture ( 11 ) in the main tube and is in fluid communication with it. The aperture is triangular, elliptical or rectangular and the side arm is cut off at an angle to leave an end portion having a circumferential length equal to the circumference of the aperture. The side arm can also include a connection socket ( 76 ) comprising a first resilient ring ( 79 ) around the arm at its end, a second resilient ring ( 80 ) spaced apart along the arm from the first ring and a zig zag resilient stent ( 82 ) between the first and second rings. The zig-zag resilient stent can be a compression stent. Both the main tube and the side arm are formed from seamless tubular biocompatible graft material.

Reinforced Vascular Prostheses

Vascular grafts for treating, reconstructing and replacing damaged or diseased cardiovascular vessels that are formed from decellularized extracellular matrix (ECM). The vascular grafts include outer or outer and inner coatings that provide structural reinforcement.

Stents with increased flexibility

Stents that are adapted to be balloon-expanded and include a plurality of rings of repeating cells, wherein adjacent rings are connected by s-shaped or omega-shaped crosslink connectors or a combination of both connectors. The configurations, materials, and/or dimensions of these devices, including the unit cells and/or crosslink connectors allow the stents to be expanded to a greater extent (e.g., up to or greater than 12 mm of diameter), and optionally with reduced foreshortening and without increasing the strain on the materials forming the crosslink connectors and unit cells. The biphasic arrangement of trapezoidal unit cells, as well as the configuration and arrangement of the s-shaped connectors, may allow these stents to expand while maintaining their radial compression strength and longitudinal compression strength with minimal recoil and stent foreshortening.

METHODS AND COMPOSITIONS FOR PROMOTING THE STRUCTURAL INTEGRITY OF SCAFFOLDS FOR TISSUE ENGINEERING

Aspects of the disclosure relate to synthetic tissue or organ scaffolds and methods and compositions for promoting or maintaining their structural integrity. Aspects of the disclosure are useful to prevent scaffold damage (e.g., delamination) during or after implantation into a host. Aspects of the disclosure are useful to stabilize tissue or organ scaffolds that include electrospun fibers. 1. A method of enhancing the mechanical properties of a synthetic or natural tubular organ scaffold , the method comprising:integrating a continuous support structure within a tubular structure, the tubular structure comprising electrospun nanofiber.2. The method of claim 1 , wherein the support structure is a coiled structure and is captured within the electropsun nanofiber structure.3. (canceled)4. The method of claim 2 , wherein the support structure or fiber is electrically conductive.5. The method of claim 2 , wherein the support structure is non-electrically conductive.6. The method of claim 2 , wherein the support structure is a metallic or polymeric structure.7. (canceled)8. (canceled)9. (canceled)10. An organ support structure comprising a conductive support structure and at least one tubular layer in overlying relationship with the conducive support structure claim 2 , the at least one electrospun layer comprising nanofibers.11. (canceled)12. The organ support structure of claim 10 , wherein the conductive support structure is selectively electrically charged13. The organ support structure of claim 12 , wherein the charge is positive claim 12 , negative claim 12 , alternating claim 12 , biphasic claim 12 , pulsed claim 12 , or ramped.14. The organ support structure of claim 10 , wherein the charge is selectively controlled/maintained in order to alter the bonding properties of electrospun nanofiber layers which come into contact with the conductive support structure15. The organ support structure of claim 10 , wherein the conductive support structure serves as the ...

COMPOSITE VASCULAR FLOW DIVERTER

A vascular flow diverter includes a tubular mesh framework which includes a mesh cover and an opening. The tubular mesh framework is collapsible and configured to expand from a collapsed shape to a tubular shape when the vascular flow diverter is deployed. The mesh cover conforms to the shape of the tubular mesh, is surrounded by the tubular mesh framework, and is less porous than the tubular mesh framework. The opening is located within the mesh cover. A delivery wire passes through the opening in order to guide the flow diverter into place over an aneurysm. 1. A vascular flow diverter comprising:a tubular mesh framework configured to transition from a collapsed configuration to an expanded configuration in response to the vascular flow diverter being deployed, the tubular mesh framework having a first porosity; anda mesh cover surrounded by the tubular mesh framework and comprising an opening sized to allow a guide member to extend through the opening, the mesh cover configured to conform to a shape of the tubular mesh framework, the mesh cover having a second porosity, the first porosity being greater than the second porosity.2. The vascular flow diverter of claim 1 , wherein the mesh cover has a rounded perimeter.3. The vascular flow diverter of claim 1 , wherein the mesh cover has a circular perimeter.4. The vascular flow diverter of claim 1 , wherein the mesh cover is integrated with the tubular mesh framework.5. The vascular flow diverter of claim 1 , wherein the mesh cover is separate from and attached to the tubular mesh framework.6. The vascular flow diverter of claim 1 , wherein the mesh cover is attached to the tubular mesh framework by welding.7. The vascular flow diverter of claim 1 , wherein the mesh cover is attached to the tubular mesh framework by interlacing mesh strands of the mesh cover with mesh strands of the tubular mesh framework.8. The vascular flow diverter of claim 1 , wherein the tubular mesh framework transitions from the collapsed ...

PANCREATIC STENT WITH DRAINAGE FEATURE

A pancreatic stent includes a main body convertible between a compressed configuration for delivery and an expanded configuration once deployed, the main body including an inner surface defining a stent lumen and an outer surface. A plurality of drainage features are formed within the outer surface of the main body, the plurality of drainage features permitting placement of the pancreatic stent within a patient's pancreas without blocking side branches of the pancreas. 1. A medical stent comprising:a main body convertible between a compressed configuration for delivery and an expanded configuration once deployed, the main body including an inner surface defining a stent lumen and an outer surface;a plurality of drainage features formed within the outer surface of the main body and at least partly formed by the outer surface of the main body, the plurality of drainage features permitting placement of the medical stent within a patient's body structure without blocking side branches of the body structure.2. The medical stent of claim 1 , wherein the main body includes an expandable metal framework.3. The medical stent of claim 2 , further comprising a polymeric layer over the expandable metal framework creating the outer surface of the main body.4. The medical stent of claim 3 , wherein the outer surface is non-uniform and includes high spots forming peaks of the plurality of drainage features.5. The medical stent of claim 3 , wherein the expandable metal framework and the polymeric layer in combination are convertible between the compressed configuration and the expanded configuration.6. The medical stent of claim 2 , wherein the expandable metal framework comprises a braided metal structure.7. The medical stent of claim 6 , wherein the braided metal structure comprises nitinol.8. The medical stent of claim 1 , wherein in the compressed configuration claim 1 , the medical stent has a diameter of at least 2 millimeters.9. The medical stent of claim 6 , wherein in the ...

STENT AND SLEEVE DEPLOYMENT

A delivery system for delivering an implant having both a rigid portion and a flexible portion to a body lumen. The delivery system includes an outer tubular member and an inner tubular member slidably disposed within the lumen of the outer tubular member. The inner tubular member includes at least one opening positioned in a side wall adjacent to a distal end region. An expandable implant, including a rigid portion and a flexible portion, is disposed about the outer surface of the inner tubular member. A distal portion of a thread is wrapped around the flexible portion of the implant and configured to maintain the flexible portion in a radially collapsed configuration during delivery of the implant. A distal end region of the outer tubular member is disposed around the rigid portion of the implant to maintain the rigid portion in a radially collapsed configuration during delivery of the implant. 1. A delivery system for delivering an implant to a body lumen , the system comprising:an outer tubular member defining a lumen;an inner tubular member defining a lumen and being slidably disposed within the lumen of the outer tubular member;an expandable implant disposed about an outer surface of the inner tubular member adjacent a distal end region of the inner tubular member, the implant comprising at least a first rigid portion and a first flexible portion; anda thread including a distal portion wrapped around an outer surface the first flexible portion of the implant thereby maintaining an entirety of the first flexible portion in a radially collapsed configuration;wherein a distal end region of the outer tubular member is disposed over the first rigid portion of the implant and is configured to maintain the first rigid portion in a radially collapsed configuration.2. The delivery system of claim 1 , wherein the thread maintains the first flexible portion of the implant in the radially collapsed configuration when the outer tubular member is not disposed over the first ...

SYSTEMS AND METHODS FOR MAKING ENCAPSULATED HOURGLASS SHAPED STENTS

Systems and methods for the manufacture of an hourglass shaped stent-graft assembly having an hourglass shaped stent, graft layers, and an assembly mandrel having an hourglass shaped mandrel portion. Hourglass shaped stent may have superelastic and self-expanding properties. Hourglass shaped stent may be encapsulated using hourglass shaped mandrel assembly coupled to a dilation mandrel used for depositing graft layers upon hourglass shaped mandrel assembly. Hourglass shaped mandrel assembly may have removably coupled conical portions. The stent-graft assembly may be compressed and heated to form a monolithic layer of biocompatible material. Encapsulated hourglass shaped stents may be used to treat subjects suffering from heart failure by implanting the encapsulated stent securely in the atrial septum to allow blood flow from the left atrium to the right atrium when blood pressure in the left atrium exceeds that on the right atrium. The encapsulated stents may also be used to treat pulmonary hypertension. 1. A stent-graft assembly comprising:an expandable stent comprising a first flared region, a neck region, and a second flared region, the neck region positioned between the first flared region and the second flared region; and the first flared region is covered by two layers of biocompatible material comprising the second graft portion and the third graft portion,', 'the neck region is covered by three layers of biocompatible material comprising the first graft portion, the second graft portion, and the third graft portion, and', 'the second flared region is covered by two layers of biocompatible material comprising the second graft portion and the first graft portion., 'a continuous biocompatible graft-tube covering the expandable stent, the continuous biocompatible graft tube comprising a first end and a second end, and first, second, and third portions, the first end of the biocompatible graft tube being an end of the first graft portion and the second end of the ...

ENDOVASCULAR STENT GRAFT ASSEMBLY AND DELIVERY DEVICE

A pre-loaded delivery device that facilitates accurate placement of a stent graft assembly in the aorta is disclosed. A stent graft is carried on the delivery device and held in a pre-deployment configuration by a sheath. A split in the sheath facilitates the pre-cannulation of one or more branch arteries extending from the aorta before the stent graft is fully released in the aorta. The stent graft comprises a tubular body having at least one scalloped fenestration formed in one end of the graft material and at least one fenestration formed in the graft material of the main tubular body. A helical internal side branch extends from the fenestration within the lumen of the main tubular body. The helical side branch is configured to curve at least partially around the scalloped fenestration. The assembly further comprises a connection stent graft extending from the fenestration into a branch vessel. 1. A system for the delivery and deployment of an endovascular stent graft comprising:a delivery device having a longitudinal axis comprising a pusher catheter having a proximal end and a distal end and defining a lumen extending between the proximal and distal ends and a guide wire catheter extending longitudinally within the lumen of the pusher catheter;a stent graft releasably coupled to the delivery device,a sheath having a proximal end and a distal end, wherein the sheath is disposed over the stent graft thereby retaining the stent graft in a radially contracted configuration on the delivery device, the sheath comprising a split located between the proximal and distal ends of the sheath thus forming a distal sheath segment located distal of the split and a proximal sheath segment located proximal of the split; andan auxiliary catheter having a proximal end and a distal end and defining a guide wire lumen therebetween, wherein the auxiliary catheter extends longitudinally under the distal sheath segment and through the sheath split between the proximal and distal ...

DEVICES FOR FLUID FLOW THROUGH BODY PASSAGES

A device includes a first end portion, a second end portion, an intermediate portion between the first end portion and the second end portion, and a graft material coupled to at least the intermediate portion. The first end portion has a first end diameter. The second end portion has a second end diameter larger than the first end diameter. The intermediate portion tapers between the first end portion and the second end portion. A method of diverting fluid flow from a first passage to a second passage comprising deploying the device in a third passage between the first passage and the second passage, expanding the first end portion against sidewalls of the first passage, and expanding the second end portion against sidewalls of the second passage. 1. (canceled)2. A device comprising:a longitudinal axis;a first end portion having a terminal first end diameter, the first end portion having a first length along the longitudinal axis, the first end portion being self-expanding;a second end portion having a second end diameter smaller than the terminal first end diameter, the second end portion being substantially cylindrical, the second end portion having a second length along the longitudinal axis, the second end portion being self-expanding;an intermediate portion between the first end portion and the second end portion, the intermediate portion tapering between the first end portion and the second end portion, the intermediate portion having a third length along the longitudinal axis, the first end portion being frustoconical, the first end portion tapering between the terminal first end diameter and the intermediate portion; anda graft material coupled to at least the intermediate portion, the device configured to provide fluid flow between a first passage in which the first end portion is anchored and a second passage in which the second end portion is anchored.3. The device of claim 2 , wherein each of the first end portion claim 2 , the second end portion claim 2 ...

FLEXIBLE HOLLOW LUMEN COMPOSITE

A composite lumen includes an extruded tube of a composite including a poly(glycerol sebacate) (PGS) matrix mixed with a PGS thermoset filler. The composite lumen also includes an overbraid structure overlying an outer surface of the extruded tube. A method of forming a composite lumen includes extruding a PGS tube of a composite including a PGS matrix mixed with a PGS thermoset filler. The method also includes applying an overbraid structure over an outer surface of the extruded tube. 1. A composite lumen comprising:an extruded tube of a composite comprising a poly(glycerol sebacate) (PGS) matrix mixed with a PGS thermoset filler; andan overbraid structure overlying an outer surface of the extruded tube.2. The composite lumen of wherein the PGS thermoset filler comprises a powder of thermoset PGS having an average particle size in the range of about 75 to about 300 microns.3. The composite lumen of claim 1 , wherein the PGS thermoset filler is present in an amount in the range of 10% to 90% by weight of the extruded tube.4. The composite lumen of claim 1 , wherein the overbraid structure comprises fibers of a bioresorbable material.5. The composite lumen of claim 4 , wherein the bioresorbable material is selected from the group consisting of polyglycolide claim 4 , polylactide claim 4 , poly(lactic-co-glycolic acid) claim 4 , poly(caprolactone) and PGS.6. The composite lumen of claim 1 , wherein the overbraid structure is laminated to the extruded tube.7. The composite lumen of claim 1 , wherein the extruded tube has an inner diameter of less than 6 mm.8. The composite lumen of claim 1 , wherein the overbraid structure has an overbraid angle in the range of 75° to 151°.9. The composite lumen of claim 1 , wherein the overbraid structure has a picks per inch in the range of 30 to 150.10. The composite lumen of claim 1 , wherein the overbraid structure has a 1×1 claim 1 , 2×2 claim 1 , or 2×1 braid pattern.11. The composite lumen of claim 1 , wherein the overbraid ...

Self-Sealing PTFE Graft with Kink Resistance

A self-sealing vascular graft, including a substrate with a sealant layer and several optional additional layers, is described. The substrate can be ePTFE and the material used for the sealant and additional layers can be polyurethane. The sealant layer and additional layers may include one or more base layers, one or more foam layers, beading of different sizes and shapes, and ePTFE tape. A flared cuff may be integral to one or both ends of the substrate or may be attached to one or both ends. Various methods of making a self-sealing vascular graft are also described, including methods of disposition, methods of forming, methods of bonding and methods of attaching. 1. A vascular graft comprising:a tubular ePTFE substrate having a first surface, a second surface, a first end portion, a second end portion, and a middle portion; anda sealant layer disposed over the first surface or the second surface,wherein the graft is self-sealing.2. The graft of wherein the substrate is any one or any combination of a high porosity graft or a thin-wall graft.3. The graft of wherein the sealant layer is disposed over any one or any combination of a first end portion claim 2 , a second end portion claim 2 , or a middle portion.4. The graft of wherein the sealant layer has a plurality of grooves.5. The graft of wherein the grooves are radial or longitudinal.6. The graft of further comprising a base layer and one or more foam layers dispersed on the base layer.7. The graft of further comprising a beading embedded in a first foam layer of the one or more foam layers.8. The graft of wherein a second foam layer of the one or more foam layers is disposed over the first foam layer and the beading.9. The graft of further comprising a polymer outer layer.10. The graft of further comprising a base layer.11. The graft of wherein the sealant layer is disposed over the first end portion and the second end portion and the sealant layer has a plurality of radial grooves.12. The graft of wherein ...

Apparatus and method for treating cardiovascular diseases

A removable apparatus is provided for temporary implantation in a pulmonary vein for ablating atrial tissue surrounding the antrum of the pulmonary vein to treat atrial fibrillation in a subject. The apparatus comprises an electrically-insulated expandable support member and a retrieval mechanism. The support member has oppositely disposed proximal and distal end portions and a main body portion extending between the end portions. The proximal end portion includes at least one annularly disposed wing member, and has a free end defined by oppositely disposed first and second major surfaces. The at least one wing member includes at least one ablation element located at the free end thereof. The retrieval mechanism is for removing the support member and for energizing the at least one ablation element. The retrieval mechanism includes at least one electrically-conductive wire, which is separately connected to the at least one wing member.

BALLOON CATHETER HAVING MULTIPLE INFLATION LUMENS AND RELATED METHODS

An apparatus is for performing a medical procedure using an inflation fluid. The apparatus includes a shaft with two inflation lumens for transmitting the inflation fluid. A balloon supported by the shaft has an interior capable of being inflated by the inflation fluid transmitted through the inflation lumens of the shaft. The tubes defining the inflation lumens provide two outlets for transmitting different flows of the inflation fluid to the interior of the balloon. A stent and related methods are also disclosed. 1. An apparatus comprising:an inflatable balloon having proximal and distal cones and an interior for receiving inflation fluid;a first tube comprising a first inflation lumen with a first outlet for transmitting a first flow of the inflation fluid to the interior of the balloon;anda second tube inside the balloon having a proximal end, a distal end, and a passage between the proximal and distal ends.2. The apparatus of adapted to transfer inflation fluid through the passage.3. The apparatus of wherein the proximal end is located within a proximal balloon cone and the distal end is located within a distal balloon cone.4. The apparatus of wherein the balloon comprises any one or any combination of a therapeutic agent claim 3 , a stent claim 3 , or a stent graft.7. The apparatus according to wherein the second tube has a wall thickness in the range of 0.0005 inches to 0.0025 inches.8. The apparatus according to whereinthe balloon further comprises a barrel between the proximal and distal cones,andthe second tube has a proximal end spaced from the first outlet and a length of the second tube is greater than or equal to a length of the barrel.9. The apparatus according to wherein the first outlet is located proximally of the balloon distal cone.10. The apparatus of further comprising a guidewire tube claim 9 , wherein the guidewire tube supports both the first tube and the second tube within the balloon.11. The apparatus of wherein the first tube extends into ...

SYSTEMS AND METHODS FOR MAKING ENCAPSULATED HOURGLASS SHAPED STENTS

Systems and methods for the manufacture of an hourglass shaped stent-graft assembly comprising an hourglass shaped stent, graft layers, and an assembly mandrel having an hourglass shaped mandrel portion. Hourglass shaped stent may have superelastic and self-expanding properties. Hourglass shaped stent may be encapsulated using hourglass shaped mandrel assembly coupled to a dilation mandrel used for depositing graft layers upon hourglass shaped mandrel assembly. Hourglass shaped mandrel assembly may have removably coupled conical portions. The stent-graft assembly may be compressed and heated to form a monolithic layer of biocompatible material. Encapsulated hourglass shaped stents may be used to treat subjects suffering from heart failure by implanting the encapsulated stent securely in the atrial septum to allow blood flow from the left atrium to the right atrium when blood pressure in the left atrium exceeds that on the right atrium. The encapsulated stents may also be used to treat pulmonary hypertension. 1. A method for making an encapsulated stent-graft , the method comprising:compressing a stent comprising a first flared region, a second flared region, and a neck region situated between the first flared region and the second flared region, into a compressed state;positioning the second flared region and the neck region within a graft tube comprising a first end and a second end;releasing the second flared region to an expanded state within the graft tube thereby depositing a first layer of graft material over the neck region and the second flared region;releasing the first flared region to expand to the expanded state;guiding the second end of the graft tube through an interior portion of the stent such that the second end of the graft tube extends beyond the first flared region, thereby depositing a second layer of graft material along the interior portion;selecting a mandrel comprising a first portion comprising a first mandrel end that is removably coupled ...

PANCREATIC STENT WITH DRAINAGE FEATURE

A pancreatic stent includes a main body convertible between a compressed configuration for delivery and an expanded configuration once deployed, the main body including an inner surface defining a stent lumen and an outer surface. A plurality of drainage features are formed within the outer surface of the main body, the plurality of drainage features permitting placement of the pancreatic stent within a patient's pancreas without blocking side branches of the pancreas. 1. A mandrel for forming an expandable stent structure , comprising: a plurality of first grooves extending helically in a first direction around a circumference of the mandrel, the plurality of first grooves defining a first base; and', 'a plurality of second grooves extending helically in a second direction around the circumference of the mandrel, the plurality of second grooves defining a second base;, 'a plurality of projections extending radially outward definingwherein the plurality of projections includes a plurality of taller projections having grooves formed therein defining a raised base that is disposed radially outward from the first base.2. The mandrel of claim 1 , wherein the raised base is disposed radially outward from the second base.3. The mandrel of claim 1 , wherein the second direction is opposite the first direction.4. The mandrel of claim 1 , wherein the plurality of taller projections are disposed along at least a portion of the mandrel.5. The mandrel of claim 1 , wherein the grooves of the plurality of taller projections extend helically along the mandrel in the first direction.6. The mandrel of claim 1 , wherein the plurality of taller projections extend radially outward farther than a remainder of the mandrel.7. The mandrel of claim 1 , wherein one or more first wires are wrapped around the mandrel in the first direction claim 1 , the one or more first wires pass over the plurality of taller projections resulting in portions of the one or more first wires extending radially ...

Intralumenal Stent Graft Fixation

This document describes intralumenal stent graft devices with integrated anchor members that are selectively deployable in situ. The deployment of the anchor members is also reversible, to thereby facilitate retrieval of the stent graft device. These stent graft devices are well-suited for sealing and repairing defects in a body lumen wall. Such defects can include, but are not limited to, aneurysms and lumen wall openings. In some embodiments, the intralumenal stent graft devices provided herein are well-suited for use in the GI tract including the colon. That is the case because the integrated anchor members provide the stent graft devices with a high level of migration resistance, whereby the stent grafts can remain resiliently located in a desired position within the GI tract despite the peristaltic movements of the GI tract. 1. An implantable stent graft device comprising:a stent frame comprised of one or more elongate members;a covering material attached to the stent frame; andone or more anchor members extending from the stent frame, wherein the one or more anchor members reconfigure from a deployed configuration to an undeployed configuration by an eversion of a portion of the stent frame.2. The device of claim 1 , wherein the one or more anchor members each comprise a hook portion with a free end claim 1 , and wherein the hook portion pivots in response to the eversion of the portion of the stent frame.3. The device of claim 1 , further comprising a purse string suture claim 1 , the purse string suture engaged with the portion of the stent frame such that tensioning the purse string suture causes the eversion of the portion of the stent frame.4. The device of claim 1 , wherein the stent frame comprises a plurality of stent rings claim 1 , and wherein the one or more anchor members extend from a single first stent ring.5. The device of claim 4 , wherein the single first stent ring is an end-most stent ring of the plurality of stent rings.6. The device of ...

Devices and methods for treating aneurysms and other vascular conditions

A fenestrated aortic cuff is configured to be delivered endovascularly to a target region, deployed, fastened, and sealed to a vessel wall, e.g., in a neck region of an aortic aneurysm. Example fenestrated cuffs provide a suitable landing zone for a commercially available endograft, which may be, in some cases, positioned below or above the renal arteries in order to complete exclusion of an abdominal aortic aneurysm (AAA) or a thoracic aortic aneurysm (TAA), respectively, from systematic circulation. In some cases, fenestrated cuff function is facilitated and improved by employing active fixation and sealing mechanisms, including, e.g., helical fasteners, which may allow deployment of the fenestrated cuff in short neck regions with limited sealing area.

Stent graft

Stent graft comprising a stent ( 1 ) having a plurality of ring segments ( 3 ) arranged side by side and connected with each other by connecting webs ( 7 ) having a meandering pattern, and at least one membrane ( 2 ), characterized in that a plurality of connecting webs ( 7 ) between adjacent ring segments ( 3 ) are provided with flexible tongues ( 6 ), which are arranged in a form-closed manner in the connecting webs ( 7 ) and which are resiliently movable against the connecting webs ( 7 ), wherein the membrane ( 2 ) being clamped between flexible tongues ( 6 ) and connecting webs ( 7 ).

METHODS FOR FLUID FLOW THROUGH BODY PASSAGES

A device includes a first end portion, a second end portion, an intermediate portion between the first end portion and the second end portion, and a graft material coupled to at least the intermediate portion. The first end portion has a first end diameter. The second end portion has a second end diameter larger than the first end diameter. The intermediate portion tapers between the first end portion and the second end portion. A method of diverting fluid flow from a first passage to a second passage comprising deploying the device in a third passage between the first passage and the second passage, expanding the first end portion against sidewalls of the first passage, and expanding the second end portion against sidewalls of the second passage. 112-. (canceled)13. A method of diverting fluid flow from a first passage to a second passage , the method comprising: inserting a first catheter in the first passage upstream of an occlusion site;', 'inserting a second catheter in the second passage; and', 'deploying a needle from the first catheter through tissue between the first passage and the second passage, and into the second passage, wherein deploying the needle comprises guiding the needle using an ultrasound transmitter;, 'forming a third passage between the first passage and the second passage, wherein the first passage is an artery and the second passage is a vein and wherein the first passage is substantially parallel to the second passage, wherein forming the third passage comprises a first end portion having a first end diameter, the first end portion having a first length along the longitudinal axis, the first end portion being substantially cylindrical;', 'a second end portion having a second end diameter larger than the first end diameter, the second end portion having a second length along the longitudinal axis;', 'an intermediate portion between the first end portion and the second end portion, the intermediate portion tapering between the first end ...

METHOD OF MANUFACTURING STENT ATTACHED TO ARTIFICIAL BLOOD VESSEL AND STENT ATTACHED TO ARTIFICIAL BLOOD VESSEL MANUFACTURED BY THE SAME

A stent may be inserted and placed in a lesion portion that is being stenosed or has been stenosed in a blood vessel or a lumen in the body to expand the lesion portion that is being stenosed or has been stenosed. Further, the stent and the artificial blood vessel layers are integrally formed with each other without floating between the stent and the artificial blood vessel layers. Accordingly, foods or other contents travelling through the pathway of a lumen in the body or blood in the vessel may be prevented from contacting the lesion portion, and the progress of the stenosis of the lesion portion may be prevented that may occur as the lesion portion grows toward the inside of the hollow cylindrical body of the stent. 1. A method of manufacturing an artificial blood vessel-attached stent , the method comprising:forming a stent having a hollow cylindrical body by crossingly weaving a superelastic shape memory alloy wire;performing attachment preparation by forming an inner artificial blood vessel layer by inclinedly winding an artificial blood vessel (PTFE: Polytetrafluoroethylene) along an outer side of a SUS rod to form an inner artificial blood vessel layer, inserting the inner artificial blood vessel layer into the stent, inclinedly winding an artificial blood vessel (PTFE; Polytetrafluoroethylene) along an outer side of the stent to form an outer artificial blood vessel layer, and inserting a silicone tube; andfixedly mounting the SUS rod inside a vacuum heating device, attaching the inner artificial blood vessel layer and the outer artificial blood vessel layer positioned at the inside and outside of the stent to each other by a vacuuming operation towards the stent with the inner artificial blood vessel layer and the outer artificial blood vessel layer internally and externally wrapping around the stent, and thermally fusing the inner artificial blood vessel layer and the outer artificial blood vessel layer to each other by a heating operation so that the ...

Layered cover material and method of use thereof

The present disclosure relates to a multi-layered cover including a reinforcement layer including polytetrafluoroethylene and an attached bonding layer, and to implantable medical devices including such a cover. In one embodiment, the bonding layer includes at least one of polyurethane, silicone and fluorinated ethylene propylene. Other aspects of the invention relate to methods of manufacturing and using such implantable devices.

Hydrogel jacketed stents

Hydrogel jacketed stents provide the ability to fill in the stent frame in vivo to at least partially cover the interior of the surface of the stent following deployment while having the convenience of attaching the jacket to the exterior of the stent. The hydrogel can be pleated and/or folder over the exterior of the stent to provide for extension of the stent without damaging the hydrogel. The hydrogel sheet can be secured at one or more points along the circumference to associate the sheet of hydrogel with the exterior surface of the stent frame. The stent can be conveniently delivered using similar technology as conventional stents if desired. The hydrogel can provide for drug delivery if desired.

Helical High Fatigue Stent-Graft

An implantable prosthesis, including a generally tubular substrate and a continuous shape memory member disposed over the outer surface of the substrate. The shape memory member may include a series of zig-zag struts alternating between a first strut with a first length and a second strut with a second length different from the first length. A graft member may be positioned over the substrate and shape memory member.

DIAMETRICALLY ADJUSTABLE ENDOPROSTHESES AND ASSOCIATED SYSTEMS AND METHODS

A diametrically adjustable endoprosthesis includes a controlled expansion element extending along at least a portion of a graft and is supported by a stent. The controlled expansion element diametrically constrains and limits expansion of the endoprosthesis. Upon deployment from a smaller, delivery configuration, the endoprosthesis can expand to the initial diameter set by the controlled expansion element. Thereafter, the endoprosthesis can be further diametrically expanded (e.g., using balloon dilation) by mechanically altering the controlled expansion element. 1. A diametrically adjustable endoprosthesis comprising:a stent-graft including a stent and a base graft secured to the stent, the base graft having a first end and a second end and the stent-graft being self-expanding and exhibiting a self-expansion force, the stent-graft having a maximum diametric expansion limit; anda controlled expansion element having a continuous wall, the controlled expansion element having an initial diametric expansion limit and being adjustable to an adjusted diameter in a range of diameters between the initial diametric expansion limit and the maximum diametric expansion limit when placed under an expansion force in addition to the self-expansion force of the stent-graft, the controlled expansion element being configured to maintain the adjusted diameter under physiological conditions following removal of the expansion force and the stent-graft being configured to limit the range of diameters for the adjusted diameter to the maximum diametric expansion limit.2. The endoprosthesis of claim 1 , wherein the controlled expansion element defines a sliding interface with the stent-graft such that during diametric expansion of the endoprosthesis claim 1 , the sliding interface between the controlled expansion element and the stent-graft permits at least a portion of the controlled expansion element to change in longitudinal dimension at a different rate than the stent-graft at the ...

Stents with metallic covers and methods of making same

All metal stent grafts and covered stents having either a single structural supporting stent member with concentrically positioned graft members on the luminal and abluminal surfaces of the stent member or a single graft member with concentrically positioned structural supporting stent members on the luminal and abluminal surfaces of the graft member are provided.

BALLOON EXPANDABLE ENDOPROSTHESIS

An improved medical device reduces the loss of longitudinal length during expansion of a stent-graft from a compressed state to an expanded state. For example, the stent-graft is placed over a cover that provides resistance to expansion of the balloon during inflation, which reduces longitudinal compressing forces exerted on the stent-graft. 1. A medical device , comprising:a stent-graft defining a first free end, a second free end, and an intermediate portion between the first and second free ends, the stent-graft having an undeployed state with an undeployed diameter and an undeployed longitudinal length between the first free end and the second free end and a deployed state with a deployed diameter and a deployed longitudinal length between the first free end and the second free end, the stent-graft including a stent portion and a graft portion; and a balloon, and', 'a cover concentrically surrounding the balloon, the intermediate portion of the stent-graft imparting a resistance to expansion of the balloon at the intermediate portion of the stent-graft and the cover also imparting a resistance to expansion of the balloon to reduce a difference in an expansion rate of the balloon at the free ends of the stent-graft relative to an expansion rate of the balloon at the intermediate portion of the stent-graft so as to reduce longitudinal compression of the stent-graft as the balloon expands the stent-graft from its undeployed state to its deployed state., 'a catheter assembly onto which the stent-graft is assembled in the undeployed state, the catheter assembly including,'}2. The medical device of claim 1 , wherein the deployed length of the stent-graft is at least 85% of the undeployed length of the stent-graft.3. The medical device of claim 1 , wherein the cover includes reinforcing portions configured to resist inflation of corresponding shoulder portions of the balloon so as to reduce longitudinal compression of the stent-graft as the balloon expands the stent- ...

STENT

The invention relates to a radially expandable stent () comprising a plurality of flexibly interconnected meandering ring elements () defining a stent () having a proximal and a distal end and a longitudinal axis, wherein said ring elements () being arranged side by side along the longitudinal axis of the stent and adjoining ring elements () being attached to each other through connection elements (), wherein connection elements () are arranged between at least two adjoining ring elements (), said connection elements each having at least one expandable expansion element with predetermined breaking point (), wherein the expansion being possible in the longitudinal and/or transverse direction and the predetermined breaking points () only disrupting after the expansion element has been overstretched beyond its maximum expansion point. 11231232344231010. Radially expandable stent () comprising a plurality of flexibly interconnected meandering ring elements ( , ) defining a stent () having a proximal and a distal end and a longitudinal axis , wherein said ring elements ( , ) being arranged side by side along the longitudinal axis of the stent and adjoining ring elements ( , ) being attached to each other through connection elements () , characterized in that connection elements () are arranged between at least two adjoining ring elements ( , ) , said connection elements each having at least one expandable expansion element with predetermined breaking point () , wherein the expansion being possible in the longitudinal and/or transverse direction and the predetermined breaking points () only disrupting after the expansion element has been overstretched beyond its maximum expansion point.24. Stent according to claim 1 , characterized by the connecting webs within the connection elements () claim 1 , which are arranged in such a way that the extension elements can be extended in stages or stepwise.3104. Stent according to claim 1 , characterized in that the predetermined ...

BRANCHING COVERED STENT-GRAFTS AND RELATED DEPLOYMENT SYSTEMS AND METHODS

A bifurcated stent-graft and stent-graft delivery system for placement and delivery into an anatomical structure of the body, such as the superior vena cava, are disclosed. The stent-graft includes a first, second and third wire portions that provide strength, flexibility, and resilience. The wire portions are incorporated and joined by a graft fabric that forms a flexible joint that provides increased flexibility. The stent-graft can also include an aperture to allow for unobstructed blood flow from branched or tributary blood vessels such as the azygos vein. 1. A stent-graft comprising:a first wire portion defining a first flowpath;a second wire portion defining a second flowpath;a third wire portion defining a third flowpath; anda flexible joint comprising a continuous sheet of fluid barrier material coupled to and interposed between the first wire portion, the second wire portion, and the third wire portion, the flexible joint defining a plenum that is fluidically coupled to each of the first flowpath, the second flowpath, and the third flowpath.2. The stent-graft of claim 1 , wherein the fluid barrier comprises PTFE or PET.3. The stent-graft of claim 1 , wherein the first wire portion claim 1 , the second wire portion and the third wire portion define an exterior surface coupled to a fluid barrier claim 1 , the fluid barrier defining a first aperture having an edge that is arranged between about 0.1 cm and about 7 cm from the flexible joint.4. The stent-graft of claim 3 , wherein the third wire portion defines a second aperture that is arranged adjacent to the first aperture of the fluid barrier.5. The stent-graft of claim 1 , wherein the first wire portion claim 1 , the second wire portion and the third wire portion define an interior surface coupled to a fluid barrier claim 1 , the fluid barrier defining a first aperture having an edge that is arranged between about 0.1 cm and about 7 cm from the flexible joint.6. The stent-graft of claim 5 , wherein the ...

STENT HAVING EXTERIOR PATH

A stent according to the present invention includes: a stent main body that has a plurality of holes formed in the surface thereof and a circumferential part of which the inside is hollow; and a cover that covers one side of the outer circumferential surface of the stent main body, in which the stent main body has an exterior path that provides a channel through which the body fluid secreted from a diverging duct can flow along the longitudinal direction of the stent main body to the outside of the cover. 1. A stent comprising:a stent main body that has a plurality of holes formed in the surface thereof and a circumferential part of which the inside is hollow; anda cover that covers one side of the outer circumferential surface of the stent main body,wherein the stent main body has an exterior path that provides a channel through which the body fluid secreted from a diverging duct can flow along the longitudinal direction of the stent main body to the outside of the cover.2. The stent of claim 1 , wherein the external path is formed by a recession on a side of the circumferential part of the stent main body and the recession is formed along the longitudinal direction of the stent main body so that the body fluid secreted from the diverging duct flows through the recession.3. The stent of claim 1 , wherein the external path is formed by a projection on a side of the circumferential part of the stent main body and the projection is formed along the longitudinal direction of the stent main body so that the body fluid secreted from the diverging duct flows through a spaced space formed between the duct and the stent main body by the projection.4. The stent of claim 1 , wherein a plurality of external paths is provided.5. The stent of claim 4 , wherein the external paths are formed by recessions and projections repeatedly formed along the circumferential part of the stent main body and the recessions and the projections are formed along the longitudinal direction of the ...

SHAPE MEMORY TUBULAR STENT WITH GROOVES

An implantable, radially distensible stent includes a tubular structure having opposed open ends. The wall of the stent is made from a shape memory polymeric material. Grooves may be disposed within an outer surface of stent wall to improve flexibility and drainage of the stent. 1. An implantable , radially distensible device comprising:a solid tubular structure having an outer circumference, an open first end and an opposed open second end, the tubular structure having a continuous wall extending around the entire outer circumference and between the first end and the second end to define an open lumen therethrough, the wall having an outer surface and an opposed inner surface defining a wall thickness therebetween, the wall comprising a shape memory polymeric material; anda graft secured to the tubular structure.2. The device of claim 1 , wherein the tubular structure includes a plurality of tubular structures spaced apart from one another.3. The device of claim 2 , wherein the plurality of tubular structures are hollow cylinders.4. The device of claim 3 , wherein the hollow cylinders are partially embedded in the graft.5. The device of claim 3 , wherein the graft includes a plurality of graft portions disposed between the spaced apart tubular structures.6. The device of claim 1 , wherein the graft completely covers the tubular structure.7. The device of claim 1 , wherein the tubular structure has a plurality of grooves disposed within the outer surface of the wall.8. The device of claim 7 , wherein the outer surface of the wall between the plurality of grooves extends parallel to a longitudinal axis of the tubular structure.9. The device of claim 8 , wherein a length of the outer surface of the wall between two adjacent grooves is greater than a width of the grooves extending along the longitudinal axis.10. The device of claim 7 , wherein the grooves are present in the wall when the device is in a radially contracted state and in a radially expanded state.11. The ...

SELECTIVE ADHERENCE OF STENT-GRAFT COVERINGS

An endoluminal prosthesis including a radially expandable support member having interior and exterior surfaces and a wall with openings, a first covering member including a biocompatible polymer material at least partially positioned against the interior surface, and a second covering member including a biocompatible polymer material at least partially positioned against the exterior surface. The first covering member attaches to the second covering member at predetermined bonding locations within less than all of the openings thereby leaving unbonded regions. 1. A prosthesis comprising:an expandable support comprising plural openings;a first covering inside of the support;anda second covering outside of the support,wherein the first and second coverings have multiple connections that extend through openings in the support and the connections form a pattern of loose space around the support.2. The prosthesis of wherein the pattern of loose space includes a pocket around the support.3. The prosthesis of wherein the prosthesis further comprises a therapeutic agent.4. The prosthesis of wherein the pocket holds the therapeutic agent.5. The prosthesis of wherein the connections additionally form a predominantly circumferential pattern.6. The prosthesis of wherein the first covering is biocompatible.7. The prosthesis of wherein the second covering is biocompatible.8. The prosthesis of wherein the support and the first covering are unconnected.9. The prosthesis of wherein the connections additionally form a predominantly longitudinal pattern.10. The prosthesis of wherein the prosthesis length is greater than the first covering length and the second covering length.11. The prosthesis of wherein the first covering and the second covering are fully bonded at their ends.12. The prosthesis of wherein the second covering is biocompatible.13. The prosthesis of wherein the first covering is biocompatible.14. The prosthesis of wherein the support and the second covering are ...

ENDOLUMINAL PROSTHESIS HAVING MULTIPLE BRANCHES OR FENESTRATIONS AND METHODS OF DEPLOYMENT

A branched and fenestrated prosthesis may include a main tubular graft body including a proximal end opening, a distal end opening, a lumen, and a sidewall. A branch may extend from the sidewall and may include a first end opening, a second end opening, and a lumen. A fenestration may be disposed in the sidewall and positioned distal of the second end opening of the branch. The branched and fenestrated prosthesis may include a plurality of branches and a plurality of fenestrations. 1. A branched prosthesis comprising:a tubular body of biocompatible graft material having a proximal end, a distal end, an internal lumen, a sidewall, and a longitudinal axis from the proximal end to the distal end;a proximal portion having a first diameter;a distal portion having a second diameter;a tapered portion between the proximal portion and the distal portion;at least one antegrade branch connected to and extending from the sidewall and having a distally extending free open, the at least one antegrade branch disposed at least partially in the tapered portion and configured to permit antegrade fluid flow therethrough;at least one unbranched fenestration in the sidewall at least partially disposed distal of the tapered portion and distal of the free open end of the at least one antegrade branch.2. The prosthesis of claim 1 , wherein the at least one antegrade branch comprises first and second antegrade branches.3. The prosthesis of claim 2 , wherein the first and second antegrade branches are both circumferentially and longitudinally offset from each other.4. The prosthesis of claim 1 , wherein the at least one unbranched fenestration comprises first and second unbranched fenestrations that are disposed distal of the tapered portion and distal of the free open end of the at least one antegrade branch.5. The prosthesis of claim 5 , wherein the first and second unbranched fenestrations are circumferentially offset from each other.6. The prosthesis of claim 2 , wherein the at least one ...

Multilayered composite

In accordance with certain embodiments of the present disclosure, a process for forming a multilayered electrospun composite is provided. The process includes forming a dispersion of polymeric nanofibers, a fiberizing polymer, and a solvent, the dispersion having a viscosity of at least about 50,000 cPs. Nanofibers from the dispersion are electrospun onto a first ePTFE layer. A second ePTFE layer is applied onto the nanofibers to form a composite structure. The composite structure is heated.

COMPOSITE LUMEN WITH REINFORCING TEXTILE AND MATRIX

A composite hollow lumen and a method for producing the lumen are provided. The lumen includes a tubular textile formed of yarns having a first tensile strength and a matrix material in which the tubular textile is embedded to form a conduit having a bore and a sidewall substantially impermeable to liquid. The matrix material has a second tensile strength that is lower than the first tensile strength. The method for producing a composite lumen includes selecting yarns having a first tensile strength, selecting an elastomeric matrix material having a second tensile strength that is lower that the first tensile strength, forming a tubular textile of the yarns, and embedding the tubular textile in the matrix material to form a conduit having a bore and conduit walls that are substantially impermeable to liquid. The elastomeric matrix material is a biodegradable or bioresorbable polyester. 1. A method for producing a composite lumen , comprising the steps of:selecting yarns having a first tensile strength;selecting an elastomeric matrix material having a second tensile strength that is lower that the first tensile strength;forming a tubular textile of the yarns; andembedding the tubular textile in the elastomeric matrix material to form a conduit having a bore and conduit walls that are substantially impermeable to liquid;wherein the elastomeric matrix material is a biodegradable or bioresorbable polyester.2. The method of claim 1 , wherein the step of selecting an elastomeric matrix material comprises selecting poly(glycerol sebacate).3. The method of claim 1 , wherein the step of forming a tubular textile comprises weaving claim 1 , knitting claim 1 , or braiding the yarns.4. The method of claim 3 , wherein the step of forming a tubular textile comprises using a circular warp knitting process.5. The method of claim 3 , wherein the step of selecting yarns comprises selecting biodegradable or bioresorbable yarns.6. The method of claim 5 , wherein the step of selecting ...

Cell impregnated sleeve for paracrine and other factor production

Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.

Stents with improved fixation

The present disclosure provides stents, particularly self-expanding stents, useful for the GI tract, and more particularly, useful for treating esophageal strictures. The stents provided herein include a medial region and proximal and distal cuffs having external diameters greater than the medial region diameter when the stent is in the deployed state. The medial region comprises an open weave wire construction. An elastomeric coating circumscribes the medial region, while the may be an extension of the wire construction or separate elements. Preferably, the cuffs have a textured surface for contact with the esophageal wall tissue to resist stent migration. The elastomer coated medial region provides a barrier to tissue ingrowth, and has an enhanced radial restoring force to maintain an open passageway in a body lumen. Optionally, the stent includes an exterior sheath with a surface pattern, to which the stent couples. A low durometer sleeve, between the stent and body lumen, axial positioning of the stent relative to the body lumen. Consequently, precision in stent placement is provided without tissue damage that could result if positioning motion occurred between the surface texture and the body lumen.

Fiber reinforced composite stents

Polymeric composite stents reinforced with fibers for implantation into a bodily lumen are disclosed.

Electrospun ptfe coated stent and method of use

A stent or other prosthesis may be formed by coating a single continuous wire scaffold with a polymer coating. The polymer coating may consist of layers of electrospun polytetrafluoroethylene (PTFE). Electrospun PTFE of certain porosities may permit endothelial cell growth within the prosthesis.

DIFFERENTIAL DILATION STENT AND METHOD OF USE

Embodiments herein provide differential dilation stents for use in percutaneous interventions, such as transluminal bypass procedures. In some embodiments, the stents may be used in the process of creating an arteriovenous (AV) fistula during a percutaneous bypass procedure, and such stents may have two or more specialized regions that are configured to adopt a predetermined diameter, shape, and/or tensile strength upon insertion in order to suit the needs of the vessel or procedure. The disclosed stents may be used for creating and/or maintaining an arterial/venous fistula for bypass of an occlusion in a cardiac artery using a cardiac vein, or the femoral artery, for example using the tibial or popliteal vein. 1. A stent configured for insertion in a human blood vessel , the stent comprising:a bent wire formed into a cylindrical body comprising a plurality of serpentine rings including a terminal ring at one end of the body and an adjacent ring inward from the terminal ring, wherein each serpentine ring comprises a plurality of axial struts, wherein circumferentially adjacent axial struts are joined by arcuate joints and wherein each serpentine ring has an inside surface, an outside surface, a proximal end, and a distal end, and wherein at least some of the axially adjacent serpentine rings other than the terminal ring and inward ring maintain a longitudinal gap between ends of adjacent arcuate joints.2. The stent of claim 1 , wherein the terminal ring ends in a tail strut and at least one strut in the terminal ring other than other than the tail strut is longer than all other struts in the terminal ring and has a length sufficient to span the terminal ring and the adjacent ring inward from the terminal ring to create an overlap which enhances the strength of the ends of the body.3. The stent of claim 2 , further comprising a flexible coating including at least one sheet or membrane covering the inside and outside surfaces of at least some of the serpentine rings ...

STENT GRAFT SYSTEMS WITH RESTRAINTS IN CHANNELS AND METHODS THEREOF

A stent graft system includes a first layer of graft material, a second layer of graft material, one or more stent members, one or more reducing belts, and a release wire. The one or more stent members are located between the first layer of graft material and the second layer of graft material. The second layer of graft material is formed to have a corresponding channel over each of the one or more stent members. The one or more reducing belts each include a loop at both ends and each is located in a corresponding channel around a corresponding one of the stent members. The release wire passes through both loops of each of the one or more reducing belts when the one or more stent members are in a compressed state. Pulling the release wire allows for the stent graft system to radially expand. 1. A stent graft system , comprising:a first layer of graft material;a second layer of graft material;a stent member located between the first layer of graft material and the second layer of graft material; anda reducing belt located at least partially in a channel between the second layer of graft material and the first layer of graft material and around at least a portion of the stent member.2. The stent graft system of claim 1 ,wherein the second layer of graft material has a shape that provides the channel between the second layer of graft material and the first layer of graft material.3. The stent graft system of claim 1 ,wherein the reducing belt has a length that is shorter than a circumference of the stent member when the stent member is fully expanded but longer than a circumference of the stent member when the stent member is in a compressed state.4. The stent graft system of claim 1 ,wherein the reducing belt includes loops and there is a corresponding loop of the loops at each end of the reducing belt.5. The stent graft system of claim 4 , further comprising:a release wire passing through the loops of the reducing belt.6. The stent graft system of claim 1 ,wherein ...

LOW PROFILE PROSTHESIS DELIVERY DEVICE

A delivery device system for delivering a low profile prosthesis and a method for releasably retaining a prosthesis on the device are described. The delivery device comprises a prosthesis disposed about the proximal end of the inner cannula. In a first configuration the prosthesis is releasably secured to the inner cannula in a radially inwardly contracted low profile delivery configuration and in a second configuration the prosthesis is at least partially radially outwardly deployed. First and second trigger wires extend longitudinally and circumferentially about the prosthesis in helical configurations. The first trigger wire is helically wound in a clockwise direction and the second trigger wire is helically wound in a counter-clockwise direction. When the first and second helical trigger wires are in a tensioned condition, the prosthesis is releasably secured to the inner cannula in a radially inwardly contracted low profile delivery configuration. 1. A delivery device system for delivering a low profile prosthesis to a body vessel comprising:an inner cannula having a proximal end and a distal end;a prosthesis formed of biocompatible graft material and having a proximal end and a distal end, the prosthesis disposed about the proximal end of the inner cannula, wherein the prosthesis comprises a first configuration in which the prosthesis is releasably secured to the inner cannula in a radially inwardly contracted low profile delivery configuration and a second configuration in which the prosthesis is at least partially radially outwardly expanded;a first trigger wire having a tensioned condition and a relaxed condition and extending longitudinally and circumferentially about the prosthesis in a helical configuration from the proximal end of the prosthesis to the distal end of the prosthesis;a second trigger wire having a tensioned condition and a relaxed condition and extending longitudinally and circumferentially about the prosthesis in a helical configuration ...

ELASTIC STENT GRAFT

A stent graft including (1) a stent having a wall having at least one opening, an outer surface, and an inner surface and (2) a covering of a composite material having a least one expanded fluoropolymer membrane and an elastomer is provided. The cover can be used to cover the outer and/or the inner surface of the stent. The expanded fluoropolymer membrane contains serpentine fibrils. In exemplary embodiments, the fluoropolymer is polytetrafluoroethylene. The composite material may be axially and/or circumferentially wrapped around the stent. The composite material is fold-free throughout its operating diameter range and exhibits a sharp increase in stiffness at a predetermined diameter. The stent graft can be designed to have a stop point in either a radial or axial direction. The stent graft can advantageously be implanted undersized with respect to a nominal diameter without having material infolding. 1. A method of manufacturing a stent graft comprising:positioning a cover comprising a composite material under tension sufficient to overcome the retraction force of said composite material on at least one surface of a stent at an expanded diameter of said stent to form a stent graft; andbonding said cover to said stent,wherein said composite material comprises at least one expanded fluoropolymer membrane and an elastomer, andwherein said expanded fluoropolymer membrane comprises serpentine fibrils.2. The method of claim 1 , wherein each said serpentine fibril has a width of about 1.0 micron or less.3. The method of claim 2 , wherein each said serpentine fibril has a width of about 0.5 micron or less.4. The method of claim 1 , wherein said cover is wrinkle-free before loading and after deployment.5. The method of claim 1 , wherein said cover is positioned on at least one of an outer surface and an inner surface of said stent.6. The method of claim 1 , wherein said at least one expanded fluoropolymer membrane comprises a plurality of pores and said elastomer is ...

Uniformly Expandable Stent

An intraluminal prosthesis includes a stent architecture having a series of stent elements repeating along a circumferential axis. One series of stent elements includes v-shaped stent elements having at least four different orientations, and V-shaped stent elements connecting adjacent v-shaped stent elements. One series of stent elements includes R-shaped stent elements having at least four different orientations, and U-shaped stent elements having at least two different orientations, the U-shaped stent elements connecting adjacent R-shaped stent elements. Adjacent series of stent elements can be connected by connectors. Portions of the stent elements may narrow in width along a length thereof. The stent architecture may include radiopaque element receiving members. The stent architecture may be formed by machining a metal or polymer tube. The intraluminal prosthesis may include one or more graft layers. 1. An intraluminal prosthesis , comprising: v-shaped stent elements having a first leg portion, a second leg portion, and a peak portion, the v-shaped stent elements having four distinct orientations with respect to the circumferential axis; and', 'V-shaped stent elements connecting adjacent v-shaped stent elements such that the second leg portion of each of the v-shaped stent elements is connected to a V-shaped element, the second leg portion of each of the v-shaped stent elements narrowing in width toward the V-shaped stent element., 'a stent architecture comprising a plurality of stent rings extending along a longitudinal axis, adjacent stent rings connected by a plurality of connectors, each of the plurality of stent rings comprising a series of stent elements repeating along a circumferential axis, the stent elements comprising2. The intraluminal prosthesis according to claim 1 , further comprising one or more graft layers attached to the stent architecture.3. The intraluminal prosthesis according to claim 2 , wherein the one or more graft layers include an ...

LOW PROFILE STENT GRAFT HAVING A CHECK VALVE

An endoluminal prosthesis is provided including an tubular graft having a proximal end, a distal end, and a main lumen disposed therein, the tubular graft comprising a first biocompatible material; a plurality of stents disposed about a surface of the tubular graft and arranged in longitudinally spaced rows; at least one aperture disposed through a sidewall of the tubular graft, the at least one aperture positioned between two longitudinally spaced rows of stents; a valve arrangement associated with the at least one aperture, the valve arrangement being secured to the graft about the at least one aperture; and, an outer liner connected to the tubular graft between the proximal end and the distal end and surrounding the valve arrangement. In some embodiments, the valve arrangement comprises a third biocompatible material having four sides, wherein three of the four sides are secured to the graft. 1. An endoluminal prosthesis , comprising:a graft having a tubular body and a surface comprising a first biocompatible material, the graft comprising a main lumen disposed therein, a proximal end, and a distal end, and an intermediate section positioned between the proximal end and the distal end,at least one aperture through a side wall of the intermediate section of the graft, the aperture in fluid communication with the main lumen;a valve arrangement connected to the intermediate section and associated with the at least one aperture, the valve arrangement having an open position and a closed position, and;a liner comprising a second biocompatible material secured about the intermediate section and surrounding the valve arrangement.2. The endoluminal prosthesis of claim 1 , wherein the second biocompatible material has greater pliability than the first biocompatible material.3. The endoluminal prosthesis of claim 1 , wherein the aperture comprises a generally circular configuration.4. The endoluminal prosthesis of claim 1 , wherein the aperture comprises a slit in a ...

METHODS AND DEVICES FOR PERCUTANEOUS IMPLANTATION OF ARTERIO-VENOUS GRAFTS

Methods, devices, and kits for implanting a vascular graft to perform hemodialysis treatments on patients with renal failure are disclosed. The kits can include access devices comprised of an access catheter having a guidewire lumen and stylet lumen, a guide tube having a curved distal end, a stylet, an actuator handle and a vascular graft. The methods describe techniques for using the described kits and devices for performing vascular procedures, such as percutaneous implantation of the vascular graft. 1. A method of percutaneously implanting an arterio-venous graft , comprising:advancing a first guidewire into a lumen of a first artery from a second artery;advancing a second guidewire into a lumen of a first vein from a second vein;advancing a first access catheter over the first guidewire into the lumen of the first artery;advancing a second access catheter over the second guidewire into the lumen of the first vein;operating a first guide tube actuator to advance a first guide tube from the first access catheter toward a portion of a wall of the first artery;operating a second guide tube actuator to advance a second guide tube from the second access catheter toward a portion of a wall of the first vein;operating a first stylet actuator to advance a first stylet along a curved path through the first guide tube and through the wall of the first artery to form an arterial exit site; andoperating a second stylet actuator to advance a second stylet along a curved path through the second guide tube and through the wall of the first vein to form a venous exit site.2. The method of claim 1 , further comprising forming a subcutaneous tunnel between the arterial exit site and the venous exit site.3. The method of claim 2 , further comprising:advancing a guide catheter over the second stylet;wherein the guide catheter passes through the venous exit site and through the subcutaneous tunnel; andwherein a distal end of the guide catheter is disposed adjacent the arterial exit ...

GRAFT WITH EXPANDABLE REGION AND METHODS OF MAKING AND USING THE SAME

A vascular graft suitable for implantation, and more particular to a vascular graft having an expandable outflow region for restoring patency of the graft after implantation into a body lumen. 1. A graft , comprising: a first fluid flow region and a second fluid flow region merging together at a junction, which is in fluid communication with an expandable third fluid flow region opposite the first fluid flow region;', 'a first aperture disposed at an outermost end of the first fluid flow region, a second aperture disposed at an outermost end of the second fluid flow region, and a third aperture disposed at an outermost end of the third fluid flow region, the second aperture of each of the first and second vessel insertion regions coupled to each other via the coupling region in a manner enabling fluid communication therebetween;, 'a first vessel insertion region, a second vessel insertion region, and a coupling region providing fluid communication therebetween, the first and second vessel insertion regions each comprising, 'a conduit having a wall, the conduit comprisingwherein the wall comprises a support structure and a biocompatible layer; andwherein the support structure along at least a portion of the third fluid flow region of at least the first vessel insertion region is under continuous compressive stress resulting from a continuous applied load caused by the biocompatible layer against the support structure.2. The graft of claim 1 , wherein the support structure along at least a portion of the third fluid flow region of the second vessel insertion region is under continuous compressive stress resulting from a continuous applied load caused by the biocompatible layer against the support structure.3. The graft of claim 1 , wherein the compressive stress resulting from the continuous applied load in the third fluid flow region is greater than a compressive stress resulting from a continuous applied load in either the first fluid flow region or the second fluid ...

IMPLANTABLE GRAFT AND METHODS OF MAKING SAME

The present invention relates to an implantable endoluminal graft. The implantable endoluminal graft is comprised of a microporous thin-film metal covering having a plurality of openings and a structural support element underlying and physically attached to the microporous thin-film metal covering, the microporous thin-film metal covering having shape memory properties. 1. An endoluminal covered-stent , comprising:a) a radially expandable stent having a proximal end, a distal end and an intermediate region, the radially expandable stent being comprised of a plurality of interconnected structural members defining a generally tubular stent member having a plurality of stent fenestrations and a plurality of attachment members associated with some of the plurality of interconnected structure members at one or more of the proximal end, distal end and intermediate region of the stent;b) a generally tubular thin film metal cover member having a plurality of microporous openings, wherein each of the plurality of microporous openings has an open surface area less than an open surface area of each of the plurality of stent fenestrations, the generally tubular thin film metal cover member is concentrically joined to at least one of a luminal surface or an abluminal surface of the stent and coupled to the stent only at the plurality of attachment members, such that the generally tubular thin film metal cover member at least partially occludes the plurality of stent fenestrations; andc) wherein the joined radially expandable stent and the generally tubular thin film metal cover member are capable of radial expansion together with one another.2. The endoluminal covered-stent of claim 1 , wherein the radially expandable stent and the generally tubular thin film metal cover member have compatible degrees of foreshortening upon radial expansion of the stent and generally tubular thin film metal cover.3. The endoluminal covered-stent of claim 1 , wherein the generally tubular thin ...

CONTROLLED DEPLOYABLE MEDICAL DEVICE AND METHOD OF MAKING THE SAME

Controlled deployable medical devices that are retained inside a body passage and in one particular application to vascular devices used in repairing arterial dilations, e.g., aneurysms. Such devices can be adjusted during deployment, thereby allowing at least one of a longitudinal or radial re-positioning, resulting in precise alignment of the device to an implant target site. 1. A method of deploying a medical device , comprising:providing a catheter having a stent graft arranged on the catheter such that a movable element coupled to a torsional member includes a portion that extends from the torsional member and forms a loop that extends circumferentially about the stent graft;advancing the stent graft to a target location within a body of a patient;expanding the stent graft from a delivery diameter to an intermediate diameter;rotating the torsional member relative to the stent graft to change a dimension of the loop, wherein rotating the torsional member in a first direction causes radial compression of the stent graft, and wherein rotating the torsional member in an opposite second direction allows radial expansion of the stent graft from the intermediate diameter to a deployed diameter;releasing the movable element from the stent graft; andwithdrawing the movable element and torsional member with the catheter from the stent graft.2. The method of claim 1 , wherein expanding the stent graft from a delivery diameter to an intermediate diameter comprises releasing a constraining sheath from the stent graft such that the constraining sheath separates to release the stent graft.3. The method of claim 2 , wherein releasing a constraining sheath from the stent graft comprises withdrawing a cord from the constraining sheath such that the constraining sheath separates to release the stent graft.4. The method of claim 1 , wherein rotating the torsional member in the first direction operates to tension the movable element.5. The method of claim 1 , wherein when the stent ...

FILAMENT-WOUND IMPLANTABLE DEVICES

A self-expanding implantable medical device formed from one or more non-interlocking filaments. Stents, stent-grafts, occluder devices, and filters are manufactured from one or more filaments utilizing a non-interlocking crossing pattern. 1. An implantable device comprising a filament-wound tubular structure having a longitudinal axis wherein the tubular structure has been formed into a shape having a pair of opposing planar forms each having a generally circular shape oriented to be substantially transverse to the longitudinal axis , said opposing planar forms having a diameter and interconnected by a waist having a diameter less than the diameters of the opposing planar forms.2. An implantable device according to wherein the waist includes an orifice extending through a center portion thereof.3. An implantable device according to wherein the device is formed of a single filament.4. An implantable device according to wherein the device is formed of a single filament.5. An implantable device according to wherein the device is removable from a body in which it has been implanted by being withdrawn into a catheter.6. An implantable device according to wherein the device is removable from a body in which it has been implanted by being withdrawn into a catheter.7. An implantable device according to wherein the device is removable by being disassembled and withdrawn into the catheter.8. An implantable device according to wherein the device is removable intact by being withdrawn into a catheter.9. An implantable device according to wherein the device is removable intact by being withdrawn into a catheter.10. An implantable device according to wherein the device is removable intact by being withdrawn into a catheter.11. An implantable device according to wherein the device further comprises a graft covering material over an outer surface of the device.12. An implantable device according to wherein the device further comprises a graft covering material over an inner surface ...

Personalized prosthesis and methods of use

A personalized prosthesis for implantation at a treatment site of a patient includes a self-expanding mesh or membrane having collapsed and expanded configurations. The collapsed configuration is adapted to be delivered to the treatment site, and the expanded configuration engages the personalized prosthesis with the treatment site. The mesh or membrane is personalized to match the treatment site in the expanded configuration, and has an outer surface that substantially matches the treatment site shape and size. The self-expanding mesh or membrane forms a central lumen configured to allow blood or other body fluids to flow therethrough. Methods of manufacturing and delivery of the personalized prosthesis are also disclosed.

INTEGRALLY WOVEN OR KNITTED TEXTILE WITH POUCH AND METHODS OF MAKING THE SAME

An integrally woven or knitted textile, such as a tubular graft or sheet, having a base textile layer, in the case of a graft, it has at least one longitudinal tubular graft portion, and at least one pouch or flap integrally woven from at least a portion of the same set of yarns. Methods of making the same are also disclosed. 1. An integrally woven or knitted textile having a first end , a second end and a length there between , comprising:at least one longitudinal textile portion woven or knitted from a set of yarns; andat least one pouch or flap woven or knitted from at least a portion of said set of yarns and integrally woven or knitted with the longitudinal tubular graft portion;wherein, if integrally woven, the set of yarns comprises at least one set of warp yarns or ends and at least one set of weft yarns or picks; andwherein, if integrally knitted, the set of yarns comprises at least one set of wale yarns and at least one set of course yarns.2. The textile of claim 1 , wherein the at least one pouch is a first pouch having an outer wall claim 1 , an inner tubular wall and an open inner space claim 1 , positioned near the first end of the textile.3. The textile of claim 2 , wherein the first pouch has a slit opening positioned substantially parallel to a longitudinal axis of the textile.4. The textile of claim 3 , wherein the slit opening is woven in the outer wall of the first pouch and extends across the first pouch.5. The textile of claim 2 , comprising a second pouch having an outer wall claim 2 , an inner wall and an open inner tubular space claim 2 , near the second end of the textile.6. The textile of claim 5 , wherein each pouch has a slit opening positioned substantially parallel to a longitudinal axis of the textile.7. The textile of claim 6 , wherein the slit opening in the first pouch and the slit opening in the second pouch are woven in the outer tubular wall of the pouch and extend across the pouch.8. The textile of claim 7 , wherein the slit ...

COMPOSITE VASCULAR FLOW DIVERTER

A vascular flow diverter includes a tubular mesh framework which includes a mesh cover and an opening. The tubular mesh framework is collapsible and configured to expand from a collapsed shape to a tubular shape when the vascular flow diverter is deployed. The mesh cover conforms to the shape of the tubular mesh, is surrounded by the tubular mesh framework, and is less porous than the tubular mesh framework. The opening is located within the mesh cover. A delivery wire passes through the opening in order to guide the flow diverter into place over an aneurysm. 1. A vascular flow diverter comprising: the tubular mesh framework is collapsible and configured to expand from a collapsed shape to a tubular shape when the vascular flow diverter is deployed;', 'the mesh cover conforms to the shape of the tubular mesh and is surrounded by the tubular mesh framework;', 'the opening is located within the mesh cover; and', 'the tubular mesh framework is more porous than the mesh cover., 'a tubular mesh framework comprising a mesh cover and an opening, where2. The vascular flow diverter of where the tubular mesh framework has a circular cross section.3. The vascular flow diverter of where the mesh cover has a rounded perimeter.4. The vascular flow diverter of where the mesh cover has a circular perimeter5. The vascular flow diverter of where the mesh cover is integrated with the tubular mesh framework.6. The vascular flow diverter of where the mesh cover is separate from and attached to the tubular mesh framework.7. The vascular flow diverter of where the mesh cover is attached to the tubular mesh framework by welding.8. The vascular flow diverter of where the mesh cover is attached to the tubular mesh framework by interlacing mesh strands of the mesh cover with mesh strands of the tubular mesh framework.9. A device for deploying a vascular flow diverter claim 1 , the device comprising:a microcatheter comprising a tubular outer wall, a distal end, and a proximal end, the distal ...

Selective Adherence of Stent-Graft Coverings

An endoluminal prosthesis including a radially expandable support member having interior and exterior surfaces and a wall with openings, a first covering member including a biocompatible polymer material at least partially positioned against the interior surface, and a second covering member including a biocompatible polymer material at least partially positioned against the exterior surface. The first covering member attaches to the second covering member at predetermined bonding locations within less than all of the openings thereby leaving unbonded regions.

BIFURCATED STENT GRAFT WITH HEMODYNAMIC BLOOD FLOW DIVIDING WALL

A bifurcated stent graft includes a stent graft body that defines exactly one main body opening and at least two exit openings. The stent graft body includes at least one stent attached to a graft fabric material, and includes a dividing wall that divides a combined flow path, into a first flow path and a second flow path that each terminate at one of the respective exit openings. The dividing wall includes a thickness profile that terminates at a leading edge radius that extends across a width of the combined flow path. 1. A bifurcated stent graft comprising:a stent graft body defining exactly one main body opening and at least two exit openings;the stent graft body includes at least one stent attached to a graft fabric material, a bifurcation and a dividing wall that divides a combined flow path into a first flow path and a second flow path that each terminate at one of the respective exit openings; andthe dividing wall includes a thickness profile that terminates at a leading edge radius that extends across a width of the combined flow path.2. The bifurcated stent graft of wherein the thickness profile of the dividing wall includes a tapered segment that begins as a tangent to the leading edge radius.3. The bifurcated stent graft of wherein the tapered segment has a length greater than double the leading edge radius.4. The bifurcated stent graft of wherein a taper angle of the tapered segment is a function of the leading edge radius and the length of the tapered segment.5. The bifurcated stent graft of wherein the tapered segment thins toward the leading edge radius.6. The bifurcated stent graft of wherein the tapered segment thickens toward the leading edge radius.7. The bifurcated stent graft of wherein one of the two exit openings is further from the bifurcation than an other one of the two exit openings.8. The bifurcated stent graft of wherein the leading edge radius is further from the bifurcation than the main body opening.9. The bifurcated stent graft of ...

TISSUE ENDOPROSTHESIS AND METHOD FOR THE PRODUCTION THEREOF

According to the invention, said tissue endoprosthesis comprises an expandable support structure or stent held between an inner tissue structure and an outer coating consisting of a hemocompatible soft synthetic material which impregnates said inner structure through the openings in said support structure. 1. A tissue endoprosthesis comprising:an expandable hollow support structure having a surface with openings; andan inner tissue structure at least partly covering the inner surface of said support structure,wherein the tissue endoprosthesis comprises an outer covering which is composed of a flexible haemocompatible synthetic material and is anchored mechanically to said inner tissue structure, said support structure being held at least partially between said outer covering and said inner tissue structure.2. The tissue endoprosthesis according to claim 1 ,wherein the flexible haemocompatible synthetic material of said outer covering impregnates said inner tissue structure at least partially.3. The tissue endoprosthesis according to claim 1 ,wherein the flexible haemocompatible synthetic material of said outer covering is an elastomer.4. The tissue endoprosthesis according to claim 3 ,wherein said elastomer is a polyurethane elastomer or a silicone elastomer.5. The tissue endoprosthesis according to claim 1 ,wherein the flexible haemocompatible synthetic material of said outer covering is pure or loaded.6. The tissue endoprosthesis according to claim 1 ,wherein the thickness of said outer covering is at least 0.1 mm and at most 5 mm.7. The tissue endoprosthesis according to claim 1 ,wherein the thickness of said outer covering is different at different locations of said endoprosthesis.8. The tissue endoprosthesis according to claim 1 ,wherein the inner tissue structure is composed of animal pericardium.9. The tissue endoprosthesis according to claim 1 ,wherein the inner tissue structure is composed of expanded polytetrafluoro-ethylene.10. The tissue endoprosthesis ...

SELF-SEALING TUBULAR GRAFTS, PATCHES, AND METHODS FOR MAKING AND USING THEM

A self-sealing tubular graft is provided for implantation within a patient's body that includes an elongate tubular body including first and second self-sealing cannulation regions and a loop region extending between the first and second cannulation regions. The loop region includes one or more reinforcement members attached to a first length of the loop region and extending at least partially around a circumference of the tubular body. For example, the reinforcement members may include one or more sinusoidal or zigzag members extending along the first length with alternating peaks and valleys extending at least partially around a circumference of the tubular body. Self-sealing patches are also provided that include one or more reinforcement members embedded within base material. 122-. (canceled)23. A tubular graft , comprising:an elongate tubular body including a first end, a second end, and a lumen extending between the first and second ends; anda first self-sealing region at least partially surrounding a first length of the tubular body, the self-sealing region including one or more reinforcement members embedded within a base material, the one or more reinforcement members comprising a first helical coil that extends axially along the first length, the helical coil applying an axially compressive force to the base material.24. The tubular graft of claim 23 , wherein the base material comprises an elastomeric material.25. The tubular graft of claim 23 , wherein the one or more reinforcement members further comprise a second helical coil that extends axially along the first length claim 23 , the second helical coil spaced apart radially from the first helical coil.26. The tubular graft of claim 25 , wherein the second helical coil is located closer to an outer surface of the base material than the first helical coil.27. The tubular graft of claim 25 , wherein the first helical coil includes windings extending in a first helical direction and the second helical ...

Artificial vascular graft

The invention relates to an artificial vascular graft comprising a primary scaffold structure encompassing an inner space of the artificial vascular graft, said primary scaffold structure having an inner surface facing towards said inner space and an outer surface facing away from said inner space, a coating on said inner surface, wherein a plurality of grooves is comprised in said coating of said inner surface. The primary scaffold structure comprises further a coating on said outer surface. The primary scaffold structure and the coating on said inner surface and on said outer surface are d designed in such a way that cells, in particular progenitor cells, can migrate from the periphery of said artificial vascular graft through said outer surface of said coating, said primary scaffold structure and said inner surface to said inner space, if the artificial vascular graft is used as intended. The invention relates further to a method for providing said graft.

CUSTOMIZED AORTIC STENT DEVICE AND METHOD OF MAKING THE SAME

The application provides customized aortic stent and stent graft devices and methods for the manufacture thereof. The customized aortic stent or stent graft are patient-specific in that they conform to at least part of the ascending aorta, aortic arch and/or thoracic aorta. 1. A method for manufacturing a vascular endoprosthesis fitting at least part of a patient's lumen anatomy , the method comprising:obtaining a 3D image of a region of the patient's lumen anatomy comprising the at least part of the patient's lumen anatomy;obtaining a corrected 3D model of the region of the patient's lumen anatomy based on the 3D image of the region of the patient's lumen anatomy;designing a 3D model of the vascular endoprosthesis based on the corrected 3D model of the region of the patient's lumen anatomy;unfolding the 3D model of the vascular endoprosthesis to a 2D pattern of the vascular endoprosthesis;manufacturing a 2D endoprosthesis structure from the 2D pattern; andassembling the 2D endoprosthesis structure to obtain a 3D endoprosthesis corresponding to the 3D model of the vascular endoprosthesis.2. The method of claim 1 , wherein obtaining the corrected 3D model of the region of the patient's lumen anatomy comprises correcting a portion of the 3D image or a 3D model based on the 3D image corresponding to a diseased portion of the region of the patient's lumen anatomy.3. The method of claim 1 , wherein obtaining the corrected 3D model of the region of the patient's lumen anatomy comprises locally enlarging or reducing a size of a portion of the 3D image or a 3D model based on the 3D image corresponding to a portion of the region of the patient's lumen anatomy.4. The method of claim 1 , wherein obtaining the corrected 3D model of the region of the patient's lumen anatomy comprises locally correcting a portion of the 3D image or a 3D model based on the 3D image corresponding to a portion of the region of the patient's lumen anatomy based on average population data.5. The ...