УСТРОЙСТВО ДЛЯ ПРОДВИЖЕНИЯ СТЕНТОВ

Изобретение относится к медицинской технике, а именно к устройствам для размещения стентов, например, в сосуде или протоке тела или в структуре, используемой для тестирования или демонстрирования (такой как полимерная трубка). Устройство для продвижения стента содержит наружный футляр и стент-зацепляющий элемент, расположенный внутри наружного футляра. Стент-зацепляющий элемент выполнен с возможностью перемещения стента в дистальном направлении из наружного футляра на протяжении по меньшей мере двух периодов зацепления стента стент-зацепляющим элементом. Каждый период зацепления выполнен с возможностью перемещения стента в дистальном направлении без механического сопутствующего возврата наружного футляра. Каждый период зацепления отделен периодом без зацепления стента стент-зацепляющим элементом, в котором стент не приводится в движение в дистальном направлении. 20 з.п. ф-лы, 16 ил.

СТЕНТ-ГРАФТ

Группа изобретений относится к медицине, а именно к лечению сосудистых патологий. Стент-графт, состоящий из стента, содержащего кольцевые сегменты, имеющие извилистую конфигурацию, расположенные бок о бок и соединенные друг с другом соединительными перемычками, и по меньшей мере одну мембрану, покрывающую всю наружную сторону стента, обернутую внутрь вокруг концов стента и зафиксированную между петлями кольцевых сегментов и соединительными перемычками, которые соединяют соседние кольцевые сегменты друг с другом, при этом мембрана зафиксирована между по меньшей мере двумя петлями второго кольцевого сегмента, если смотреть c концов стента, и соединительными перемычками с соседним концевым кольцевым сегментом. Способ изготовления стент-графта включает отгибание внутрь по меньшей мере одной петли кольцевого сегмента, который расположен около периферического кольцевого сегмента, обертывание трубчатой мембраны вокруг по меньшей мере одного периферического кольцевого сегмента таким образом, чтобы ...

МЕДИЦИНСКОЕ УСТРОЙСТВО ДЛЯ ПЛАСТИКИ ГРУДИ

Изобретение относится к медицине. Медицинское устройство для пластики груди первоначально сформировано из внеклеточного матрикса (ECM) квадратичной формы, имеющего полусферическую, параболоидную, эллипсоидную или гиперболоидную форму. Упомянутый внеклеточный матрикс имеет трехмерную форму в развернутом виде и является свернутым для получения тела продолговатой формы, имеющего центральное сечение (SM), большее чем дистальные сечения (SD), и при этом упомянутое тело продолговатой формы сужается на концах. Изобретение обеспечивает предотвращение посещения операционной для ревизионного хирургического вмешательства по поводу провисания тканей субмаммарной борозды, происходящего в результате неестественного веса и объема силиконового протеза, устанавливаемого с целью дополнения чаще всего между большой грудной мышцей и молочной железой. 5 з.п. ф-лы, 5 ил.

Соединитель для защитного устройства индивидуального пользования, в частности для устройства защиты органов слуха

Группа изобретений относится к области медицины и медицинской техники. Предлагается соединитель для защитного устройства индивидуального пользования, а также способ его применения и хранения. Соединитель имеет исходную длину (L1). Соединитель, будучи растянут, самостоятельно сохраняет свою длину (L2) в растянутом состоянии. Кроме того, соединитель выполнен с возможностью самостоятельного перехода при нагревании из растянутого состояния в восстановленное состояние (L3). При этом соединитель может быть растянут до длины, которую предпочитает пользователь; а после использования устройства соединитель может быть сокращен до длины для его хранения. В случае если длина соединителя в растянутом состоянии больше, чем предпочитаемая пользователем, соединитель может быть сокращен до требуемой длины в восстановленном состоянии. Соединитель может быть изготовлен из смеси полимеров, включающей этиленвинилацетат и термопластический полиуретан. Изобретение позволяет повысить комфортность использования ...

Гибкий стент

ОДНОСТУПЕНЧАТОЕ РАСШИРЕНИЕ СПЛАВОВ С ПАМЯТЬЮ ФОРМЫ

... 1. Способ образования изделия из сплава с памятью формы (SMA), содержащий:а. создание изделия из сплава SMA, имеющего исходную форму, при этом сплав SMA имеет температуру установления формы;b. нагрев изделия из сплава SMA до примерной температуры установления формы;с. деформирование изделия из сплава SMA при его примерной температуре установления формы до окончательной формы иd. охлаждение сжатого изделия из сплава SMA, по существу удерживающего вышеуказанную окончательную форму.2. Способ по п. 1, в котором после деформирования вышеуказанного изделия из сплава SMA на этапе с) осуществляют выдержку вышеуказанного деформированного изделия из сплава SMA при его примерной температуре установления формы.3. Способ по п. 1, в котором вышеуказанный сплав SMA является нитинолом.4. Способ по п. 3, в котором вышеуказанная температура установления формы составляет примерно от 300 примерно до 650°С.5. Способ по п. 1, в котором деформирование изделия из вышеуказанного сплава SMA до вышеуказанной окончательной ...

ПРОТЕЗ АОРТАЛЬНОГО КЛАПАНА

УСТРОЙСТВО ДЛЯ ПРОДВИЖЕНИЯ СТЕНТОВ

... 1. Устройство, содержащее:наружный футляр; истент-зацепляющий элемент, расположенный внутри наружного футляра;в котором стент выполнен с возможностью перемещения в дистальном направлении из наружного футляра на протяжении, по меньшей мере, двух периодов зацепления стента стент-зацепляющим элементом, при этом каждый период зацепления выполнен с возможностью приведения стента в перемещение в дистальном направлении без механического сопутствующего возврата наружного футляра, причем каждый период зацепления отделен периодом без зацепления стента стент-зацепляющим элементом, в котором стент не приводится в движение в дистальном направлении.2. Устройство по п.1, дополнительно содержащее стент, расположенный внутри наружного футляра.3. Устройство по п.2, в котором стент имеет дистальный конец, проксимальный конец и полость, простирающуюся между дистальным концом и проксимальным концом, при этом стент-зацепляющий элемент расположен, по меньшей мере, частично внутри полости стента.4. Устройство ...

МЕДИЦИНСКОЕ УСТРОЙСТВО ДЛЯ ПЛАСТИКИ ГРУДИ

СПОСОБЫ ДЛЯ СКРЕПЛЕНИЯ КОНЦОВ НИТЕЙ И ПОЛУЧЕННЫЕ В РЕЗУЛЬТАТЕ УСТРОЙСТВА

... 1. Способ формирования саморасширяющегося стента, содержащий следующие стадии:образование первого изгиба в каждой из множества нитей, каждая из которых включает в себя часть нити на обоих сторонах первого изгиба нити, при этом каждая часть нити имеет конец;сплетание частей нити, при этом каждый конец частей нити расположен вблизи первого конца нити после сплетания частей нити;термообработка множества нитей в течение первого периода времени после сплетания частей нити;образование второго изгиба каждой из множества нитей.2. Способ по п.1, дополнительно содержащий термообработку множества нитей в течение второго периода времени после формирования вторых изгибов нитей.3. Способ по п.1, дополнительно содержащий обратное заплетание некоторых частей нити после формирования вторых изгибов нитей, которое содержит их прохождение, по меньшей мере, двумя пересечениями нити от первого конца стента.4. Способ по п.1, дополнительно содержащий обрезку частей нити.5. Способ по п.1, в котором множество нитей ...

УСТРОЙСТВА ДЛЯ ТЕРАПИИ НАРУШЕНИЙ ФУНКЦИИ СЕРДЦА

ЭНДОПРОТЕЗ С ВЫРОВНЕННЫМИ НОЖКАМИ ДЛЯ УПРОЩЕНИЯ КАНЮЛЯЦИИ

... 1. Разветвленный эндопротез, содержащий:трансплантатный компонент и по меньшей мере один опорный компонент, совместно определяющие корпусную часть, первую ножечную часть и вторую ножечную часть; иразъемное крепление, выравнивающее первую ножечную часть и вторую ножечную часть относительно друг друга для упрощения канюляции второй ножечной части.2. Эндопротез по п. 1, в котором разъемное крепление содержит привязь, торцевая оконечность которой заправлена под неразвернутые части муфты, окружающей разветвленный эндопротез.3. Эндопротез по п. 1, в котором разъемное крепление содержит привязь, торцевая оконечность которой пропущена под одной или несколькими вершинами по меньшей мере одного опорного компонента.4. Эндопротез по п. 1, в котором первая ножечная часть, по существу, аксиально длинней второй ножечной части.5. Эндопротез по п. 1, в котором первая ножечная часть и вторая ножечная часть конструктивно отклонены под углом в разные стороны, образуя Y-образную конфигурацию.6. Эндопротез по ...

Стент

Изобретение относится к стентам, используемым для расширения просвета стенозированной части в случае, когда в биологическом органе, имеющем структуру с просветом, таком как кровеносный сосуд, возникает стеноз или тому подобное. Стент содержит первый каркас, второй каркас, первую удлинительную часть, вторую удлинительную часть и перемычку. Первый каркас расположен вдоль цилиндрической поверхности и образует волнообразную форму, направление амплитуды которой является осевым направлением цилиндрической поверхности. Второй каркас расположен вдоль цилиндрической поверхности, образует волнообразную форму, направление амплитуды которой является осевым направлением, и расположен смежно с первым каркасом в осевом направлении. Первая удлинительная часть сформирована на первом гребне и проходит вдоль первой биссектрисы, делящей первый гребень пополам, с обеих сторон относительно первой биссектрисы в направлении второго каркаса, при этом первый гребень представляет собой по меньшей мере один из гребней ...

Neurovaskuläres Brückenimplantat

Distale Schutzvorrichtung

Verfahren zur Herstellung eines Stents

AXIALES WIRBELIMPLANTAT

Medical device with plasma modified oxide layer and method of forming such a device

Implantable medical device with flexible connection

An implantable double-ended medical device 10 such as a filter or occluder has first and second conical material capture filter baskets 12, 14 disposed in opposing orientations with their narrow ends 18 facing one another in an hourglass arrangement and connected by a flexible connector 26, which enables the implantable medical device 10 to curve within a curved vessel of a patient. The flexible connector 26 may be a coiled wire, helically cut cannula, made from a flexible material, formed by a flexible rod with transverse grooves, channels or recesses or be integral with shape memory alloy or spring steel framework of the material capture baskets - and is either closed or has a lumen passing therethrough with a closure element such as valve or incorporating thrombogenic fibres for closing the lumen after deployment of the device 10 within a patient.

STENT AND METHOD OF INSERTING A STENT INTO A DELIVERY CATHETER

A stent 2 and method of inserting a stent 2 into a delivery catheter are disclosed. In a disclosed embodiment, a stent 2 for redirecting blood flow away from an aneurysmal sac is provided. The stent comprises an elongate frame that is radially contractable from a fully radially expanded state (Figure 2) to a radially contracted state (Figure 3) in a process involving elongation of the frame. The fully radially expanded state represents the state of the frame at body temperature when no external force is applied to the frame. In the radially contracted state the frame has a maximum lateral dimension that is at least 30% smaller than the maximum lateral dimension of the frame in the fully radially expanded state. The frame further comprises a low porosity region 4 for positioning at the opening to the aneurysmal sac, the low porosity region having a porosity of less than 50% when the frame is in the fully radially expanded state.

Method of manufacturing stent attached to artificial blood vessel and stent attached to artificial blood vessel manufactured by the same

A method of manufacturing an artificial blood vessel attached stent, the method comprising forming a stent 10 having a hollow cylindrical body by cross weaving a super-elastic shape memory alloy wire 2, performing attachment preparation by forming an inner artificial blood vessel layer 31 by inclined winding an artificial blood vessel (PTFE, polytetrafluoroethylene) 5 along the outer side of a rod 20 to form an inner artificial blood vessel layer 31, inserting the inner artificial blood vessel layer 31 into the stent 10. Winding an artificial blood vessel 5 along an outer side of the stent 10 to form an outer artificial blood vessel layer 32, and inserting a silicon tube 40. Fixedly mounting the rod 20 inside a vacuum heating device 50, attaching the inner artificial blood vessel layer 31 and the outer artificial blood vessel layer 32 positioned at the inside and outside of the stent to each other by vacuuming operation towards the stent 10 with the inner artificial blood vessel layer 31 ...

Orthopaedic implants and prosthesis

Spinal implantation device

Implantable flow diverter

SELF ACTUATED BREAST LESION PROBE

Prosthetic heart valve

ANNULUSVERSTÄRKENDES VOLUME

EQUIPMENT FOR THE TREATMENT OF THE SURFACE OF A JOINT

DEVICE FOR THE EXECUTION OF THERAPEUTHI TREATMENTS IN THE SPINAL COLUMN

FEMURKOPF ARRANGEMENT WITH VERANDERLICHER SHIFT

DEVICE FOR THE ATTACHMENT OF A CONTAINER ANASTOMOSIS

FABRIC WITH THREADS FROM A FORM MEMORY ELEMENT

DISTAL SAFETY DIVICE

COATED MEDICAL DEVICE

FLEXIBLE HIP JOINT PAN AND PROCEDURE FOR THE PRODUCTION OF SUCH

NOT KAPSULÄRES INTRAOKULARLINSEN IMPLANT

DYNAMIC KNEE BALANCER WITH PRESSURE MEASUREMENT

SURGICAL CLIP

IN-SITU MANUFACTURE INTERVERTEBRALE FUSION DEVICE

UNIFORMLY AKKOMMODIERENDE INTRAOKULARLINSEN (AIOLS) AND DISCRETE ONE OF BASIS ELEMENTS FOR USE THEREBY

SYSTEMS FOR THE SPINAL COLUMN SURGERY

EXPAND-CASH INTERMEDIATE EDDY IMPLANT

IN-VIVO-SENSOR AND PROCEDURE FOR ITS PRODUCTION

PROCEDURE FOR THE EMPLOYMENT OF A MEDICINE PRODUCT INTO A RELEASE SYSTEM

FABRIC MOUNTING DEVICES

EXPAND-CASH SPINAL COLUMN IMPLANT

CONTAINER IMPLANT

DEVICE FOR THE ATTACHMENT OF CONTAINER ANASTOMOSES

BILATERAL LAMINOPLASTIE IMPLANTS

ARTIFICIAL VOLUME DISK FOR THE LENDENWIRBELBEREICH

ENDOLUMINALE SIDE BRANCH PROSTHESIS

GRAFT ADJUSTMENT

HERZKLAPPENERSATZ STENTVENTILE ONE AS WELL AS EQUIVALENT SURGERY PROCEDURE AND - SYSTEMS

DISTAL SAFETY DIVICE

FIXING RING TO ENDO OR EXTRAKAPSULÄREN PROTHETI RECONSTRUCTION IN THE FRONT PARAGRAPH REGION OF THE HUMAN EYE

SURGICAL DEVICE

ELECTRICALSURGICAL EQUIPMENT

SURGICAL PATCH AS WELL AS INTRODUCTION DEVICE

WOVEN INTRAVASKUL�RE DEVICE AND PROCEDURE FOR THE PRODUCTION

DEVICE FOR BRINGING IN A MEDICAL TRANSPLANT

EMPFÄNGNISVERHÜTUNGSSYSTEM

ARTIFICIAL INTERMEDIATE EDDY IMPLANT

MEDICAL TRANSPLANT LINKS

USER PROGRAMMABLE COMBINATION OF SPUTTERED PARTICLES FOR ELECTROMAGNETICALLY INDUCING CUTTING

CATHETER SYSTEM FOR THE ATTACHMENT OF A STENT

PROSTHESIS FOR CONTROLLING THE RIVER DIRECTION IN A BODY CONTAINER

BONE TRANSPLANT MATRIX

SAMPLING FROM A SUCTION BLISTER

Heat tunable intraocular lens

A method and system provide an ophthalmic lens (110) including a lens body (120) having a chamber (126) therein, a reservoir module (130) coupled with the lens body and an optical fluid (140). At least part of the lens body is flexible. The reservoir module includes a reservoir (132A, 132B) and a heat sensitive portion (134) bordering the reservoir. The reservoir has a reservoir volume and is fluidically connected with the chamber. The heat sensitive portion has a shape responsive to a temperature of at least forty five degrees Celsius such that the reservoir volume changes in response to at least part of the heat sensitive portion reaching the temperature. The optical fluid resides in the chamber and the reservoir. A change in the reservoir volume flows a portion of the optical fluid between the reservoir and the chamber such that the flexible portion of the lens body undergoes a shape change corresponding to a base power change.

Cell encapsulation devices with controlled cell bed thickness

An implantable containment apparatus for receiving and retaining a biological moiety, including a plurality of cells, for insertion into a patient, such as into a tissue bed, is disclosed. The device includes a cell encapsulating pouch that forms and interior volume having a reservoir space for receiving cells, where the reservoir space includes first and second interior surfaces, and a tensioning member to maintain an average distance between the first interior surface and the second interior surface.

Spiral-based thin-film mesh systems and related methods

A spiral-based thin-film mesh for medical devices and related methods is provided. The spiral -based thin-film mesh may be used as a stent cover for a stent device. The thin-film mesh may include a plurality of spirals. The spirals allow the thin-film mesh to expand omni-directionally. In one or more embodiments, the spirals may be logarithmic spirals, golden spirals, approximated golden spirals, box Phi spirals, or Fibonacci spirals. The thin-film mesh may be formed from thin-film Nitinol (TFN), and may be fabricated via sputter deposition on a micropatterned wafer.

Leaflet frame attachment for prosthetic valves

Described embodiments are directed toward centrally-opening leaflet prosthetic valves having a frame and a leaflet construct. Leaflet frame attachments for prosthetic valves include the leaflet construct being at least partially coupled to a frame outer side by a looped structure.

Prosthetic valves with mechanically coupled leaflets

Described embodiments are directed toward centrally-opening leaflet prosthetic valve devices having a leaflet frame and a mechanically coupled leaflet. The described leaflet frames have projections that are configured to couple with a leaflet attachment region of a leaflet. Some embodiments include a leaflet retention feature that engages the leaflet frame projections and operates to secure the leaflet to the leaflet frame. Methods of making and using such prosthetic valve devices are also described.

IMPROVEMENTS FOR PROSTHETIC VALVES AND RELATED INVENTIONS

This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.

Implantable damping device for modifying blood flow characteristics

An implantable damping device (100) for modifying blood flow characteristics in a vessel (50), the device (100) including: a first expansion chamber (110) having a first chamber proximal end (130), a first chamber distal end (170) and a first chamber intermediate portion (140) having a larger cross-sectional area than the first chamber proximal and distal ends (130), wherein the first expansion chamber (110) generates a pressure drop in blood flow downstream of the device (100) relative to blood flow upstream of the device (100).

Medical devices and anchors therefor

Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for placement in vessels, appendages, and openings in a body including a frame having a proximal end, a distal end, and a longitudinal axis. In certain instances, the frame includes a waist portion angled relative to the longitudinal axis and one or more anchors arranged along the waist portion.

Surgical scaffold

Modular hip prosthesis

Endovascular heart valve replacement comprising tissue grasping elements

Radially extended support member for spinal nucleus implants and methods of use

HIGH STRENGTH VACUUM DEPOSITED NITIONOL ALLOY FILMS, MEDICAL THIN FILM GRAFT MATERIALS AND METHOD OF MAKING SAME

A graft fixation device and method

Method and apparatus for the treatment of the intervertebral disc annulus

Side branched endoluminal prostheses and methods of delivery thereof

Method of doping surfaces

Disclosed herein are methods of treating an article surface. The method comprises removing a metal oxide surface from the metal substrate to expose a metal surface; and delivering particles comprising a dopant from at least one fluid jet to the metal surface to impregnate the surface of the article with the dopant. The method also comprises delivering substantially simultaneously a first set of particles comprising a dopant and a second set of particles comprising an abrasive from at least one fluid jet to a surface of an article to impregnate the surface of the article with the dopant.

Method and apparatus for replacing the function of facet joints

Stent graft and introducer assembly

A stent graft (40) for treating Type-A dissections in the ascending aorta (22) is provided with a plurality of diameter-reducing suture loops (56-60) operable to constrain the stent graft during deployment thereof in a patient's aorta. The diameter-reducing loops (56-60) allow the stent graft (40) to be partially deployed, in such a manner that its location can be precisely adjusted in the patient's lumen. In this manner, the stent graft can be placed just by the coronary arteries (26, 28) with confidence that these will not be blocked. The stent graft (40) is also provided with proximal and distal bare stents (44,52) for anchoring purposes.

Suction blister sampling

Medical instruments and devices and parts thereof using shape memory alloys

Stent

Method and device for optimizing vision via customization of spherical aberration of eye

Artificial lenses and methods for optimizing vision in an eye of a patient comprising the steps of determining a target optical configuration including the optimum defocus and aberrations that the patients' eye should have in order to match or approximate the original optical configuration of the patient; determining the refractive change of the patient's eye required to achieve the optical configuration best corresponding to target optical configuration for the patient; and implementing the selected refractive change to achieve the target optical configuration.

Ear scaffold

A scaffold (6) for reshaping the cartilaginous portion of an ear. The scaffold is formed of shape memory material and in the form of a horseshoe shape, or is formed from a thermoplastic pliable material.

Implantable vein frame

An implantable vein frame is contemplated in which two ring members are rigidly joined in spaced axial alignment via one or more interconnecting members. One of the one or more interconnecting members defines a protruding region that acts upon the implant placed within the frame and/or the vein that the vein frame is placed within to define a sinus region. The implant is placed within and scaffolded by the vein frame, and the vein frame is subsequently inserted within a vein via a venotomy, or interposed between two vein segments via vein interposition graft. The vein frame acts to support the structural integrity of the implant, and to scaffold and anchor the implant in place with the vein.

Adjustable percutaneous annuloplasty devices, delivery systems, a method for percutaneously deploying an annuloplasty device and a method performed by one or more processing devices

Electrosurgical apparatus

Telescoping prosthetic valve and delivery system

A prosthetic valve for replacing a native valve of a patient's anatomy comprises: an anchor frame subcomponent; a valve frame subcomponent nestable within the anchor frame subcomponent; and a tissue retention feature configured to engage tissue associated with the native valve and secure the leaflet of the native valve between the valve frame subcomponent and the anchor frame subcomponent. 18222086_1 (GHMatters) P113410.AU.1 ...

Stent for vessels

Bone grafting matrix

Intravitreous self adaptive stent

Disclosed herein are devices, methods and kits for a stent for treating an eye, comprising a flexible material, wherein the stent is self adaptive to a dimension of a vitreous cavity in the eye.

Hydrogel jacketed stents

Hydrogel jacketed stents provide the ability to fill in the stent frame in vivo to at least partially cover the interior of the surface of the stent following deployment while having the convenience of attaching the jacket to the exterior of the stent. The hydrogel can be pleated and/or folder over the exterior of the stent to provide for extension of the stent without damaging the hydrogel. The hydrogel sheet can be secured at one or more points along the circumference to associate the sheet of hydrogel with the exterior surface of the stent frame. The stent can be conveniently delivered using similar technology as conventional stents if desired. The hydrogel can provide for drug delivery if desired.

Proximally Self-Locking Long Bone Prosthesis

A femoral stem hip implant for insertion into a surgically created aperture in a femur includes a monolithic femoral stem made of shape memory material. The stem is configured to be inserted into the aperture, has a proximal portion and a longitudinal axis. The shape memory material within the proximal portion has a cross-section perpendicular to the longitudinal axis. At least a portion of the shape memory material within the proximal portion is in a compressed state by application of a plurality of compressive forces at a temperature below an austenitic finish temperature of the shape memory material so that the cross-section expands through shape memory effect via the formation of austenite in response to a temperature increase after insertion into the aperture thereby causing a locking-force to be exerted against an inner surface of the aperture, the locking force being sufficient to stabilize the implant in the aperture.

Method of Accessing the Left Common Carotid Artery

Single filter and multi-filter endolumenal methods and systems for filtering fluids within the body. In some embodiments a blood filtering system captures and removes particulates dislodged or generated during a surgical procedure and circulating in a patient's vasculature. In some embodiments a filter system protects the cerebral vasculature during a cardiac valve repair or replacement procedure.

Implantable and lumen-supporting stents and related methods of manufacture and use

An implantable medical stent system, including a radially expandable stent including a filamental structure in a pattern surrounding a bore to form a substantially tubular wall along a length relative to a longitudinal axis; wherein the filamental structure includes at least one actuate crown with a crown peak having a radius of curvature located along a reference axis, and first and second arcuate crown shoulders on first and second sides, respectively, of the reference axis; and wherein the filamental structure also includes at least one pair of adjacent first and second elongated struts extending from the first and second crown shoulders, respectively.

Thoracic aorta stent graft

A stent graft for placement in the thoracic arch of a patient has a tubular body defining a main lumen therethrough, a plurality of zig zag stents along the tubular body, each of the stents comprising a plurality of struts and bends, the bends being between adjacent struts. At least a first stent and an adjacent second stent having at least a pair of adjacent bends on the first stent aligned with an adjacent pair of bends on the second stent, whereby a first pair of adjacent struts of the first stent and a second pair of adjacent struts of the second adjacent stent together define a diamond shape region. A recess is within the diamond shaped region with the recess extending into the lumen of the tubular body. A fenestration extending into the tubular body within the recess in the diamond shaped region and a graft tube leading from the fenestration into the main lumen. There can be one, two or three diamond shaped regions, recesses, fenestrations and graft tubes Proximally of the or each diamond shaped region the tubular body has a first diameter, distally of the diamond shaped region the tubular body has a second diameter and in the region of the tubular body around the diamond shaped region the tubular body has a third diameter, the first diameter being greater than the second diameter and both the first and second diameter being greater than the third diameter whereby a central region is defined which will allow circumferential blood flow during an operation out of the graft tube into the recess and then into the central region.

In-situ intervertebral fusion device and method

An orthopedic device for implanting between adjacent vertebrae comprising: an arcuate balloon and a hardenable material within said balloon. In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means.

Low profile intervertebral implant

The present invention is directed to a low profile intervertebral implant ( 10 ) for implantation in an intervertebral disc space (D) in-between adjacent vertebral bodies (V). The intervertebral implant includes a plate ( 40 ) preferably coupled to a spacer ( 20 ). The plate is preferably formed from a first material and the spacer is preferably formed from a second material, the first material being different from the second material. The plate is preferably sized and configured so that the plate does not extend beyond the perimeter of the spacer. In this manner, the plate preferably does not increase the height profile (hs) of the spacer and the plate may be implanted within the intervertebral disc space in conjunction with the spacer.

Heart valve repair devices and methods

Devices and methods for the repair of the functioning of heart valves are provided. A device may comprise a first section having a generally spiral shape and a second section connected to the first section. A method involves positioning the device such that chords associated with the heart valve are positioned within the path of the generally spiral shape of the first section and positioning the second section on an opposite side of the heart valve. The first section may be turned in a manner such that the chords move closer to the center of the first section. The first section draws the chords closer together, thereby pulling the valve leaflets closer together in order to facilitate their coaptation and proper closing.

Dynamic knee balancer with pressure sensing

A device for performing a surgical procedure on a knee includes an adjustable femoral portion, a tibial portion and at least one sensor coupled with the femoral and/or tibial portions to sense pressure exerted by the femoral and tibial portions against one another. The femoral portion is adapted for removably coupling with a distal end of a femur to adjust tension in soft tissue adjacent the knee and has at least one positioning feature adapted to move relative to the distal end of the femur as the femoral portion is adjusted, thus helping position a femoral prosthetic on the distal end of the femur. The sensor(s) may be adapted to sense pressure at medial and lateral sides of the knee, and relative pressures may be displayed as data on a visual display. Adjustments to the femoral member may be made to balance pressure at flexion and extension of the knee.

Surgical spreadable sheet delivery and positioning system and method

A prepackaged mesh unit which comprises a spreadable sheet, a guide rod configured for remotely positioning the spreadable sheet within a body cavity, and a plurality of self-extending elements collapsed with the spreadable sheet and held at one end by the guide rod, wherein the self-extending elements have an elastic property and store elastic energy while collapsed with the spreadable sheet, wherein the number and configuration of the self-extending elements is selected to match a size and shape of the spreadable sheet.

In vivo sensor and method of making same

Implantable in vivo sensors used to monitor physical, chemical or electrical parameters within a body. The in vivo sensors are integral with an implantable medical device and are responsive to externally or internally applied energy. Upon application of energy, the sensors undergo a phase change in at least part of the material of the device which is then detected external to the body by conventional techniques such as radiography, ultrasound imaging, magnetic resonance imaging, radio frequency imaging or the like. The in vivo sensors of the present invention may be employed to provide volumetric measurements, flow rate measurements, pressure measurements, electrical measurements, biochemical measurements, temperature, measurements, or measure the degree and type of deposits within the lumen of an endoluminal implant, such as a stent or other type of endoluminal conduit. The in vivo sensors may also be used therapeutically to modulate mechanical and/or physical properties of the endoluminal implant in response to the sensed or monitored parameter.

Branch vessel prostheses

The present embodiments provide a branch vessel prosthesis for placement at least partially between a main vessel and a branch vessel of a patient. The branch vessel prosthesis has a graft including a generally tubular body of a biocompatible material. At least one stent is coupled to a proximal region of the graft, and at least one stent is coupled to a distal region of the graft. The proximal region of the graft includes a generally straight configuration in an expanded deployed state that is substantially parallel to a longitudinal axis of a main vessel. The distal region of the graft includes a generally straight configuration in the expanded deployed state that is substantially parallel to a branch vessel. A curvature of a central region varies an angle in which the distal region of the graft is disposed relative to the proximal region.

Device and method for replacing mitral valve

A prosthetic mitral valve assembly is disclosed. The assembly comprises a radially-expandable stent including a lower portion sized for deployment between leaflets of a native mitral valve and an upper portion having a flared end. The upper portion is sized for deployment within the annulus of the mitral valve and the flared end is configured to extend above the annulus. The stent is formed with a substantially D-shape cross-section for conforming to the native mitral valve. The D-shape cross-section includes a substantially straight portion for extending along an anterior side of the native mitral valve and a substantially curved portion for extending along a posterior side of the native mitral valve. The assembly further includes a valve portion formed of pericardial tissue and mounted within an interior portion of the stent for occluding blood flow in one direction.

Endoluminal prosthesis with steerable branch

An endoluminal prosthesis may include a tubular main graft body including a sidewall and proximal and distal ends. A first stent may be positioned near the proximal end of the main graft body. A second stent may be positioned adjacent to and distal of the first stent. An opening in the sidewall may be positioned longitudinally between a peak of the first stent and a valley of the second stent. A tubular branch may be disposed in the opening. The branch may include first and second end openings. The branch may be flexibly orientable between a retrograde configuration in which the first end opening is oriented toward the distal end and the second end opening is oriented toward the proximal end and an antegrade configuration in which the first end opening is oriented toward the proximal end and the second end opening is oriented toward the distal end.

Embolic protection devices and related systems and methods

According to one aspect of the disclosure, an embolic protection device is provided comprising an elongate element having a deflector at its distal end. The embolic protection device is generally configured to redirect and/or funnel embolic debris and permit at least a portion of the blood, no longer containing the redirected and/or funneled embolic debris, to perfuse the surrounding vasculature and/or tissue.

Device for endovascular aortic repair and method of using the same

A device and method for endovascular repair of a patient's aorta is disclosed. The device includes a frame component that has a balloon-expandable frame and a self-expanding frame secured to the balloon-expandable frame. The device also includes a valve element positioned at the proximal end of the frame component. The device may include another prosthetic component that may be secured to the frame component. The prosthetic component may include at least one conduit configured to receive a covered stent.

Pelvic Implant System and Method

Systems and methods are provided and adapted to engage and pull (e.g., pull up) or reposition urethral support tissue, such as the portion of the perineal membrane above or below the urethra. The perineal membrane intersects the urethra and vagina at the midurethra or distal location and can thus be stabilized or controlled in a manner that helps restore continence.

Two-stage collapsible/expandable prosthetic heart valves and anchoring systems

Prosthetic heart valve apparatus is adapted for delivery into a patient in a circumferentially collapsed condition, followed by circumferential re-expansion at the implant site in the patient. The apparatus includes an annular anchoring structure that can be implanted in the patient first. The apparatus further includes an annular valve support structure, which supports a flexible leaflet structure of the valve. The support and leaflet structures are initially separate from the anchoring structure, but they can be implanted in the patient by interengagement of the support structure with the already-implanted anchoring structure.

Device and method for reducing mitral valve regurgitation

In one embodiment, the present invention provides a prosthesis that can be implanted within a heart to at least partially block gaps that may be present between the two mitral valve leaflets. In one preferred embodiment, the prosthesis includes an anchoring ring that expands within the left atrium to anchor the prosthesis and a pocket member fixed to the anchoring ring. When the mitral valve is open, blood flows past the pocket member, maintaining the pocket member in a collapsed state. When the mitral valve closes, the backpressure of the blood pushes into the pocket member, expanding the pocket member to an inflated shape. The mitral valve leaflets contact the expanded pocket member, allowing the prosthesis to block at least a portion of the openings between the leaflets, thereby minimizing regurgitated blood flow into the left atrium.

Percutaneous transcatheter repair of heart valves

Apparatus, systems, and methods are provided for repairing heart valves through percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves. An annuloplasty ring includes an outer hollow member including a plurality of segments. Adjacent segments cooperate with one another to change the outer hollow member from an elongate insertion geometry to an annular operable geometry. The annuloplasty ring also includes an internal anchor member located at least partially within the outer hollow member. The internal anchor member includes a plurality of anchors configured to attach the annuloplasty ring to tissue of a heart valve annulus. The internal anchor member is configured to move the plurality of anchors with respect to a plurality of windows in the outer hollow member to selectively deploy the plurality of anchors through the respective windows.

Method and Device for Percutaneous Valve Annuloplasty

A delivery system for delivery of a radially expandable device to an implantation site in a patient, the delivery system including an elongated tubular member comprising a distal tip and an outer surface, first and second balloon portions spaced proximally from each other and the distal tip along a length of the tubular member, an annular space between the first and second balloon portions, a plurality of clip deployment tubes extendably moveable relative to the outer surface of the tubular member, and a plurality of clips, wherein each clip is moveable within a length of one of the clip deployment tubes between a retracted position and a deployed position.

Intraocular implants and related kits and methods

Devices, methods and kits are described for reducing intraocular pressure. The devices include a support that is implantable within Schlemm's canal and that may restore or maintain at least partial patency of the canal without substantially interfering with transmural or transluminal fluid flow across the canal. The devices utilize the natural drainage process of the eye and may be implanted with minimal trauma to the eye. Kits may include a support and an introducer for implanting the support within Schlemm's canal. Methods may include implanting a support within Schlemm's canal, where the support is capable of restoring or maintaining at least partial patency of the canal without substantial interference with transmural or transluminal fluid flow across the canal.

Blood flow disruption devices and methods for the treatment of vascular defects

A blood flow disruption device for embolizing blood flowing into a vascular defect between a proximal vascular segment and a distal vascular segment, wherein the device includes a porous inner flow disruption element configured to extend through the defect between the proximal vascular segment and the distal vascular segment, whereby a first portion of the blood flowing into the inner flow disruption element from the proximal vascular segment is directed to flow into the defect and a second portion of the blood flowing into the inner flow disruption element is directed to flow into the distal vascular segment. A porous outer flow disruption element coaxially surrounds the inner flow disruption element and is radially expansible from a collapsed state to an expanded state. The outer flow disruption element, in its expanded state, promotes sufficient hemostasis of the first portion of the blood within the defect to embolize the defect.

Expanding ocular implant devices and methods

Disclosed herein are devices and methods related to implants for treating one or more physiological conditions of the eye. Some embodiments disclosed herein include an expandable ocular implant for implanting in an eye. The expandable implant can include an implant having an elongate tubular body and an expandable sheath securely adapted to a part of the implant. Some embodiments of the expandable sheath can have at least one expandable feature that can assist the expandable sheath in forming a compact and an expanded configuration.

Expandable support device and method of use

An expandable support device for tissue repair is disclosed. The device can be used to repair hard or soft tissue, such as bone or vertebral discs. A method of repairing tissue is also disclosed. The device and method can be used to treat compression fractures. The compression fractures can be in the spine. The device can be deployed by compressing the device longitudinally resulting in radial expansion.

KINK RESISTANT GRAFT

A kink resistant stent graft includes a graft forming a tube with a central lumen extending from a first end of the tube to a second end of the tube and a stent secured to the graft adjacent the first end of the tube. The graft includes a corrugated inner graft layer forming at least a middle portion of the tube, and an outer graft layer covering the corrugated inner graft layer. 1. A method of forming a kink resistant graft comprising:wrapping a film to form an inner graft layer forming a tube with a central lumen extending from a first end of the tube to a second end of the tube;scrunching the inner graft layer to form corrugations in the inner graft layer, the corrugations providing a stored length of the corrugated inner graft layer of at least twenty-five percent;wrapping an outer graft layer over the corrugated inner graft layer to cover the corrugated inner graft layer; andbonding the outer graft layer to the corrugated inner graft layer to form the kink resistant graft.2. The method of claim 1 , further comprising securing a stent to the graft adjacent the first end of the tube.3. The method of claim 1 , wherein wrapping the film to form the inner graft layer forming the tube includes wrapping more than one layer of the film to form the tube.4. The method of claim 1 , further comprising claim 1 , after wrapping the film to form the inner graft layer forming the tube and before scrunching the inner graft layer to form the corrugations in the inner graft layer claim 1 , heating the wrapped film to set the film in the tube.5. The method of claim 1 , further comprising claim 1 , after wrapping the outer graft layer over the corrugated inner graft layer to cover the corrugated inner graft layer claim 1 , bonding the wrapped outer graft layer to the corrugated inner graft layer.6. The method of claim 1 , wherein the kink resistant graft is configured to resist kinking while experiencing a 90 degree bend with an internal fluid pressure of at least 100 mmHg in that ...

Delivery and retrieval devices and methods for side-deliverable transcatheter prosthetic valves

A delivery system for side-delivery of a prosthetic valve includes a compression device defining a lumen having a first perimeter at a proximal end that is larger than a second perimeter of the lumen at a distal end. A loading device is coupleable to the compression device and defines a lumen having substantially the second perimeter. A distal end of the loading device includes a first gate that is movable between an open state and a closed state to at least partially occlude the lumen of the loading device. A delivery device defines a lumen having substantially the second perimeter. A proximal end of the delivery device is coupleable to the distal end of the loading device and includes a second gate movable between an open state and a closed state to at least partially occlude the lumen of the delivery device.

Prosthetic Heart Valves And Apparatus And Methods For Delivery Of Same

Apparatus and methods are described herein for use in the transvascular delivery and deployment of a prosthetic heart valve. In some embodiments, an apparatus includes an outer sheath, a tube member movably disposed within the outer sheath, a retention device coupled to the tube member, and a valve holder. A prosthetic heart valve is disposed within the outer sheath and includes an outer frame and an inner frame that is removably coupled to the valve holder. The outer frame is disposed in an inverted configuration relative to the inner frame. A first actuation wire is releasably coupled to a first portion of the outer frame and releasably coupled to the retention device at a first location on the retention device. A second actuation wire is releasably coupled to a second portion of the outer frame and releasably coupled to the retention device at a second location on the retention device. 1. A method , comprising:inserting a distal end portion of a delivery sheath of a valve delivery device into a left atrium of a heart, the delivery sheath having a prosthetic heart valve disposed within a lumen of the delivery sheath, the prosthetic heart valve having an outer frame coupled to an inner frame, the outer frame being inverted relative to the inner frame, the prosthetic heart valve being releasably coupled to a retention device, the retention device including a proximal retention member defining a first opening, a center retention member including a first pin and a second pin, and a distal retention member defining a second opening, an actuation wire being coupled to the prosthetic heart valve and including a first loop secured to the retention device with the first pin and a second loop secured to the retention device with the second pin;moving the prosthetic heart valve distally out of the distal end portion of the delivery sheath;moving the retention device proximally such that the actuation wire pulls the outer frame of the prosthetic heart valve proximally and the ...

CARDIAC VALVE COMMISSURE BRACE

A brace for mounting to an annulus of a cardiac valve, the brace comprising: first and second bottom gripping wings for gripping the annulus; first and second top gripping wings for gripping the annulus; and a support bridge that connects the top wings to the bottom wings; wherein the brace is formed from a shape memory alloy and is deformable from a delivery configuration to a deployed configuration and in the delivery configuration the top wings are oriented substantially back to back along an axis and the bottom wings are oriented substantially back to back along the same axis, and in the deployed configuration the first top and first bottom gripping wings face each other to grip the annulus between them and the second top and second bottom gripping wings face each other to grip the annulus between them. 1. A brace for mounting to an annulus of a cardiac valve , the brace comprising:first and second bottom gripping wings for gripping the annulus;first and second top gripping wings for gripping the annulus; anda support bridge that connects the top wings to the bottom wings;wherein the brace is formed from a shape memory alloy and is deformable from a delivery configuration to a deployed configuration and in the delivery configuration the top wings are oriented substantially back to back along an axis and the bottom wings are oriented substantially back to back along the same axis, and in the deployed configuration the first top and first bottom gripping wings face each other to grip the annulus between them and the second top and second bottom gripping wings face each other to grip the annulus between them.2. The brace according to wherein the brace comprises a wireform having first and second wire-loops connected by the support bridge.3. The brace according to wherein the support bridge comprises at least one wire segment.4. The brace according to wherein the first top and first bottom gripping wings are wireform gripping wings comprised in the first wire-loop.5 ...

Distal End Structure of Sheath for Delivering Interventional Instrument and Sheath

A distal end structure of a sheath for delivering an interventional instrument includes a tubular body section which has opposite distal and proximal sides. A plurality of elastic expansion pieces is arranged circumferentially at the distal side of the body section at intervals. Each expansion piece assumes a converged configuration extending in an axial direction of the body section and a flared configuration away from each other. A connecting strip is provided between two adjacent expansion pieces, and two ends of the connecting strip are respectively connected to expansion pieces at respective sides at connection positions adjacent to distal ends of the expansion pieces. In the converged configuration of each expansion piece, a middle portion of the connecting strip is folded and received in a region between two adjacent expansion pieces; and in the flared configuration of each expansion piece, the middle portion of the connecting strip is unfolded. 120-. (canceled)21. A distal end structure of a sheath for delivering an interventional instrument , comprising a tubular body section , the body section having opposite distal and proximal sides , a plurality of elastic expansion pieces being arranged circumferentially at the distal side of the body section at intervals , each expansion piece assuming a converged configuration extending in an axial direction of the body section and a flared configuration away from each other , wherein a connecting strip is provided between two adjacent expansion pieces , and two ends of the connecting strip are respectively connected to expansion pieces at respective sides at connection positions adjacent to distal ends of the expansion pieces , whereinin the converged configuration of each expansion piece, a middle portion of the connecting strip is folded and received in a region between two adjacent expansion pieces; andin the flared configuration of each expansion piece, the middle portion of the connecting strip is unfolded.22. ...

CAPSULOTOMY DEVICE AND METHOD

A capsulotomy device has a tool holder. The tool holder includes a cutting blade at its distal end and is arranged to move in a distal direction in the device to form an operative state of the device where the cutting blade projects out of a distal end of the capsulotomy device. The at least a portion of the tool holder is adapted in the device's operative state to reciprocate in the distal and proximal directions to urge rotation of the cutting blade. 1. A capsulotomy device comprising a tool holder , the tool holder comprising a circular cutting blade at its distal end and being arranged to move in a distal direction in the device to form an operative state of the device where the cutting blade projects out of a distal end of the capsulotomy device , wherein the tool holder comprising an axially extending rod that is connected at its distal axial end to the cutting blade and is adapted in the device's operative state to reciprocate in the distal and proximal directions to urge oscillating rotation of the cutting blade.2. The capsulotomy device of and comprising a piston and the tool holder being coupled to the piston at its proximal end claim 1 , wherein the urging of the tool holder in the distal direction is via the piston.3. The capsulotomy device of claim 2 , wherein the piston is actuated claim 2 , possibly electrically actuated claim 2 , to urge the tool holder in the distal direction.4. The capsulotomy device of claim 2 , wherein the piston is manually activated.5. The capsulotomy device of and comprising a driving mechanism for reciprocating the at least portion of the tool holder in the distal and proximal directions.6. The capsulotomy device of claim 5 , wherein the driving mechanism is manually activated.7. The capsulotomy device of claim 5 , wherein the driving mechanism is automatically activated claim 5 , for example via an electrical motor.8. The capsulotomy device of claim 1 , wherein the tool holder comprises an outer tube and the rod extending ...

PERFUSION BALLOON WITH AN EXPANDABLE INTERNAL LUMEN

The present invention relates to a perfusion balloon catheter that has an expandable (enlargeable) inner lumen with a novel design feature that allows a continuous flow through this enlarged lumen sufficient perfusion to the distal lumen of the blood vessel or air passage concurrent to and independently of balloon inflation or deflation resulting in the prolonged dilatation and avoiding the high risks of blood or air flow stricture during balloon inflation. 1. A perfusion balloon catheter device which creates pulsative perfusion of air , blood or any liquid during balloon inflation in trachea , blood vessel , artery or vein with a constant flow , characterized by comprising;{'b': 114', '101, 'An internal lumen () made of Nylon-12, polyether block amide (PEBA), or polyurethane (PU) attached to the external surface of the self/mechanically expandable stent frame (),'}{'b': '101', 'a self/mechanically expandable stent frame () utilized as a skeleton to increase the cross-section of the blood perfusion lumen to create sufficient blood perfusion to the distal vessel or tissues which is made of a shape-memory metallic wire,'}{'b': '102', 'an inner lumen () for the balloon catheter system used as a guidewire lumen made of Nylon-12, polyether block amide (PEBA), or polyurethane (PU),'}{'b': '103', 'a radiopaque marker band () made of platinum-iridium to visualize the balloon location under fluoroscopy,'}{'b': '105', 'a kink-resistant inflation lumen () for the balloon catheter made of Nylon-12, polyether block amide (PEBA), or polyurethane (PU),'}{'b': 106', '101', '102, 'a connecting strut () of the self/mechanically expandable stent frame () to the external surface of the inner lumen () made of shape-memory metallic wire,'}{'b': '107', 'a balloon catheter main shaft () to push and pull the total system made of Nylon-12, polyether block amide (PEBA), or polyurethane (PU),'}{'b': '108', 'one or more fenestration holes () to create perfusion of the connection part of the ...

Tensioning rings for anterior capsules and accommodative intraocular lenses for use therewith

A tensioning device for attaching to the anterior capsule of an eye, and accommodative intraocular lens systems employing the device. The tensioning device includes a biocompatible, elastically reconfigurable ring for restoring at least a portion of the anterior capsule centripetal forces lost by capsulorhexis. The tensioning device also includes a plurality of penetrators configured for attaching the ring to the anterior capsule. The plurality of penetrators is biocompatible with the eye and partially embedded in a part of the ring configured for facing the anterior capsule.

HEART VALVE PROSTHESIS

A stent () used for a heart valve prosthesis and the heart valve prosthesis that includes the stent () and is used for heart valve replacement. The stent is configured to support a heart valve () and includes, along a longitudinal axis, an inflow section (), an outflow section () and a transition section () between the inflow section () and the outflow section (). The stent () has a contracted delivery configuration and an expanded deployed configuration. In the expanded deployed configuration, the inflow section () defines a concave contour that is complementary to a structure of a native valve annulus. The concave contour enables self-deployment and close adherence of the stent (), thereby preventing its displacement and perivalvular leakage after implantation. 1. A stent for use in a heart valve prosthesis , the stent configured to support a heart valve and comprising , along a longitudinal axis , an inflow section , an outflow section and a transition section between the inflow section and the outflow section , the stent having a contracted delivery configuration and an expanded deployed configuration ,wherein in the expanded deployed configuration, the inflow section defines a concave contour that is complementary to a structure of a native valve annulus.2. The stent according to claim 1 , wherein the stent is a self-expanding stent comprising a mesh having a plurality of mesh cells.3. The stent according to claim 2 , wherein ones of the plurality of mesh cells in the inflow section corresponding to the concave contour are larger than remaining ones of the plurality of mesh cells in the inflow section.4. The stent according to claim 1 , wherein in the expanded deployed configuration claim 1 , the stent conically tapers from the inflow section toward the transition section and flares from the transition section toward the outflow section.5. The stent according to claim 1 , wherein the inflow and outflow sections have ends slightly contracted so as to be tapered. ...

STENT AND REPLACEMENT HEART VALVE PROSTHESIS WITH IMPROVED FIXATION FEATURES

The present invention relates to an improved stent and a replacement heart valve prosthesis exhibiting improved fixation features. 1. Mesh stent wherein the stent comprises one or more re-enforced areas.2. Mesh stent according to further comprising one or more fixation loops.3. Mesh stent according to wherein the one or more fixation loops are characterized by a wire extending from and returning to the stent forming a loop extending outwardly from the stent claim 2 , preferably in an angle of 30°-90° claim 2 , preferably 50°-60° in proximal direction (in inflow direction) claim 2 , preferably located in the sub-annular area of the stent (ventricular area) claim 2 , preferably wherein a number of loops is located circumferentially of the stent with the same or different distances between each other claim 2 , or/and are positioned in several rows or levels claim 2 , or/and are positioned in different rows or/and in alternating positions.4. Mesh stent according to wherein the loops are formed as oval claim 3 , round claim 3 , open claim 3 , closed claim 3 , or/and tapered geometry claim 3 , or as drops.5. Mesh stent according to or wherein the loops are in the range of 2 mm-15 mm in length claim 3 , or/and the loops are in the range of 2 mm-10 mm in diameter.6. Mesh stent according to claim 3 , or wherein the loops are formed in an atraumatic design.7. Mesh stent according to any of to wherein the loops are designed to flip over in distal direction (in outflow direction) during reloading of the stent into the catheter in situ.8. Mesh stent according to any of - wherein the re-enforced area is re-enforced by a stabilizer and/or one claim 3 , two or more additional mesh layers claim 3 , preferably wherein the stabilizer is at least one or two nitinol rings claim 3 , preferably attached inside or outside of the mesh stent claim 3 , or combined with or introduced into the mesh of the mesh stent claim 3 , preferably wherein the at least one nitinol ring has an undulating ...

DEVICES, SYSTEMS, AND METHODS FOR ANCHORING AN ARTIFICIAL CHORDAE TENDINEAE TO A PAPILLARY MUSCLE OR HEART WALL

The present disclosure relates generally to the field of medical devices for delivering artificial chordae tendineae in a patient. In an embodiment, an anchor is movable between a delivery configuration and a deployed configuration, the anchor being in the delivery configuration when disposed within a delivery catheter, the anchor being in the deployed configuration when the anchor is moved beyond a distal end of the delivery catheter. When the anchor is in the delivery configuration it has a first outer dimension and when the anchor is in the deployed configuration it has a second outer dimension, the first outer dimension being smaller than the second outer dimension. The anchor is engageable with a papillary muscle or a heart wall when the anchor is in the deployed configuration and is also coupleable to an artificial chordae tendineae to anchor the artificial chordae tendineae to the papillary muscle or heart wall. 1. A system for anchoring an artificial chordae tendineae to papillary muscle or heart wall , the system comprising:an anchor movable between a delivery configuration and a deployed configuration, the anchor being in the delivery configuration when disposed within a delivery catheter, the anchor being in the deployed configuration when the anchor is moved beyond a distal end of the delivery catheter;wherein:when the anchor is in the delivery configuration the anchor has a first outer dimension and when the anchor is in the deployed configuration the anchor has a second outer dimension, the first outer dimension being smaller than the second outer dimension;the anchor is engageable with a papillary muscle or a heart wall when the anchor is in the deployed configuration, andthe anchor is coupleable to the artificial chordae tendineae to anchor the artificial chordae tendineae to the papillary muscle or heart wall.2. The system of claim 1 , wherein the anchor comprises a plurality of arms coupled at a proximal end thereof to a body portion claim 1 , at ...

PERCUTANEOUS TRANSCATHETER REPAIR OF HEART VALVES VIA TRANS-APICAL ACCESS

Apparatus, systems, and methods are provided for repairing heart valves through percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves via a trans-apical approach to accessing the heart. A guiding sheath may be introduced into a ventricle of the heart through an access site at an apex of the heart. A distal end of the guiding sheath can be positioned retrograde through the target valve. An annuloplasty ring arranged in a compressed delivery geometry is advanced through the guiding sheath and into a distal portion of the guiding sheath positioned within the atrium of the heart. The distal end of the guiding sheath is retracted, thereby exposing the annuloplasty ring. The annuloplasty ring may be expanded from the delivery geometry to an operable geometry. Anchors on the annuloplasty ring may be deployed to press into and engage tissue of the annulus of the target valve. 1. A system for percutaneous transcatheter delivery of an annuloplasty ring to repair a target valve of a heart via a trans-apical approach , the delivery apparatus comprising:a guide sheath having a lumen therethrough and configured to be positioned into the heart via an access site through a wall of the heart at the apex of the heart, the guide sheath having a length configured to be positioned through a ventricle of the heart, retrograde through the target valve, and into an atrium of the heart;a delivery assembly configured to be positioned within the guide sheath and advanced to a distal portion of the guide sheath; andthe annuloplasty ring configured to be arranged in a compressed delivery geometry within a plane that is transverse to a longitudinal axis of the lumen of the guiding sheath, wherein the annuloplasty ring comprises a plurality of anchors configured to be pressed into and engage tissue of an annulus of the target valve.2. The system of claim 1 , wherein the delivery assembly comprises a balloon assembly comprising:an upper balloon portion defining an ...

SELF-SUPPORTING LAMINATED FILMS, STRUCTURAL MATERIALS AND MEDICAL DEVICES MANUFACTURED THEREFROM AND METHODS OF MAKING SAME

Metal foils, wires, and seamless tubes with increased mechanical strength are provided. As opposed to wrought materials that are made of a single metal or alloy, these materials are made of two or more layers forming a laminate structure. Laminate structures are known to increase mechanical strength of sheet materials such as wood and paper products and are used in the area of thin films to increase film hardness, as well as toughness. Laminate metal foils have not been used or developed because the standard metal forming technologies, such as rolling and extrusion, for example, do not lend themselves to the production of laminate structures. 1. An implantable medical material comprising a self-supporting monolithic structure composed of a plurality of layers of at least one biocompatible metal material , at least one of the plurality of layers consisting of a radiopaque biocompatible material.2. The implantable medical material according to claim 1 , wherein the biocompatible metal material is selected from the group consisting of titanium claim 1 , vanadium claim 1 , aluminum claim 1 , nickel claim 1 , tantalum claim 1 , zirconium claim 1 , chromium claim 1 , silver claim 1 , gold claim 1 , silicon claim 1 , magnesium claim 1 , niobium claim 1 , scandium claim 1 , platinum claim 1 , cobalt claim 1 , palladium claim 1 , manganese claim 1 , molybdenum and alloys thereof claim 1 , zirconium-titanium-tantalum alloys claim 1 , nitinol claim 1 , and stainless steel.3. The implantable medical material according to claim 1 , wherein the plurality of layers further comprise an interface region between adjacent pairs of plurality of layers claim 1 , wherein the interface region is characterized by a local concentration of grain boundaries that is higher than a local concentration of grain boundaries within the biocompatible metal materials of the plurality of layers.4. The implantable medical material according to claim 3 , wherein the interface region further comprises a ...

Device for treating regurgitation of tricuspid and implantation method therefor

A device for treating regurgitation of a tricuspid valve (4) is disclosed. The device comprises a tricuspid valve plug (21) capable of compressing and expanding and a tricuspid valve plug fixing device used for anchoring the tricuspid valve-in-plug (21) to an orifice of the tricuspid valve (4). The tricuspid valve plug (21) is provided with an inflow end (42, 52) and an opposite outflow end (47, 57), and a prosthetic valve (50, 70) capable of being opened and closed is disposed in the tricuspid valve plug (21). When the tricuspid valve (4) is dosed, the prosthetic valve (50, 70) is automatically closed, and when the tricuspid valve (4) is opened, the prosthetic valve (50, 70) is automatically opened.

METHODS FOR ANCHORING A HEART VALVE PROSTHESIS IN A TRANSCATHETER VALVE IMPLANTATION PROCEDURE

Methods of deploying and securing a heart valve prosthesis are disclosed. A heart valve prosthesis () having a plurality of anchor guides () is loaded within a catheter-based delivery device, wherein each of the anchor guides is releasably engaged by a respective elongate member () and wherein tensioning of the elongate members aids in collapsing the prosthesis during loading. The delivery device is advanced via a transcatheter procedure to position the heart valve prosthesis at an implantation site. The heart valve prosthesis undergoes controlled deployment by controlling the release of tension on the elongate members. After deployment of the heart valve prosthesis, an anchor tool () is advanced along a guide member to the anchor guide positioned at a securement site. When the securement site is reached, an anchor clip () is released from the anchor tool to secure the prosthesis to the heart. 1. A method of securing a heart valve prosthesis to a heart of a patient comprising:implanting a heart valve prosthesis having an anchor guide within one of a native heart valve or a previously implanted heart valve prosthesis, the anchor guide having an elongate guide member releasably secured thereto with an end or ends of the elongate guide member extending externally of the patient;advancing an anchor tool having an anchor clip loaded therein along the elongate guide member to the anchor guide of the heart valve prosthesis;positioning the anchor tool at a securement site on the heart valve prosthesis; andreleasing the anchor clip from the anchor tool at the securement site to secure the heart valve prosthesis to the heart.2. The method of claim 1 , wherein the anchor guide is a rail attached to one or both of a frame and a graft material of the heart valve prosthesis.3. The method of claim 2 , wherein the rail extends parallel to a strut of the frame with a first end disposed adjacent to a crown of the frame and a second end disposed along the strut.4. The method of claim ...

METHOD FOR REPLACING A HEART VALVE

A method for replacing a native heart valve in need thereof comprises delivering to the native heart valve an apparatus comprising a valve member, a connecting member, and an anchor member suitable for anchoring the apparatus. The valve member reversibly moves between an open position and a closed position to augment or replace the function of the native valve leaflets, thereby reducing valve regurgitation. Some embodiments include a stent that is positioned in the native heart valve with the valve member disposed therein. 1. A method for replacing a function of a native heart valve , the method comprising:compressing a valve-replacement apparatus to a small diameter;delivering the valve-replacement apparatus to a native mitral valve using a catheter;expanding a stent of the valve-replacement apparatus within the native mitral valve, the stent at least partially covered, a valve member disposed within the stent, the valve member including a plurality of pericardial tissue flaps arranged side-by-side with adjacent surfaces having coaptation areas in close contact with each other to prevent leakage between the flaps;extending a portion of a first end of a flexible connecting member through a tissue wall, a second end of the connecting member coupled to an outflow portion of the valve-replacement apparatus; andsecuring a disk-shaped element to the connecting member, the disk-shaped element contacting the tissue wall, to fix a position of the valve member within the native mitral valve.2. The method of claim 1 , wherein extending the portion of the first end of a flexible connecting member through the tissue wall includes extending the portion of the first end of a flexible connecting member through an interventricular muscular septum or a muscular ventricular wall.3. The method of claim 1 , wherein the disk-shaped element is a first disk-shaped element claim 1 , the method further comprising securing a second disk-shaped element to the connecting member claim 1 , the ...

Intra-aortic emboli protection filter device

An embolic protection device including a porous deflector screen including a filter, arranged to expand and to conform to a wall of the aortic arch covering entrances to arteries branching from an aorta, an emboli collector including a cylinder arranged to expand and to lie along walls of a descending aorta, pushing against walls of the descending aorta and anchoring the porous deflector screen, and a connecting portion for connecting the porous deflector screen and the emboli collector, arranged to push the porous deflector screen against a wall of the aortic arch while anchoring against the emboli collector. Related apparatus and methods are also described.

Heart valve sealing devices and delivery devices therefor

An exemplary implantable prosthetic device has a paddle frame, an inner paddle, and an outer paddle. The outer paddle is connected to the inner paddle. The inner and outer paddles are connected to the paddle frame at a connection between the inner paddle and the outer paddle. The paddle frame can be positioned inside the inner paddle, outside the outer paddle, or between the inner and outer paddles.

Subannular Sealing for Paravalvular Leak Protection

A prosthetic heart valve for replacing a native valve includes a collapsible and expandable stent extending between a proximal end and a distal end. The stent includes an annulus section adjacent the proximal end and having a first diameter, a plurality of first struts forming cells, and a plurality of second struts connected to the annulus section and forming a plurality of deflecting cells expandable to define a second diameter larger than the first diameter. A valve assembly is disposed within the stent and a cuff is coupled to the stent and covers the plurality of deflecting cells. 1. A prosthetic heart valve for replacing a native valve , comprising:a collapsible and expandable stent extending between a proximal inflow end and a distal outflow end, the stent including an annulus section adjacent the proximal end and having a first diameter, a plurality of first struts forming first cells, and a plurality of second struts connected to the annulus section and forming a plurality of second cells expandable to define a second diameter larger than the first diameter, the second cells being positioned nearer the proximal end than are the first cells;a valve assembly disposed within the stent; anda cuff coupled to the stent and covering the plurality of second cells, the cuff including an abluminal portion disposed on an abluminal surface of the stent, and a luminal portion disposed on a luminal surface of the stent.2. The prosthetic heart valve of claim 1 , wherein each of the second cells includes upper struts and lower struts claim 1 , the upper struts being joined to the lower struts at an angle of between about 90 degrees and about 145 degrees.3. The prosthetic heart valve of claim 1 , wherein the heart valve is implantable within a native valve annulus and a portion of the second cells is disposed below the native valve annulus when implanted.4. The prosthetic heart valve of claim 1 , wherein the second diameter is about 4.0 mm to about 6.0 mm larger than the ...

Force transducting inflatable implant system including a dual force annular transduction implant

An implant system for restoring and improving physiological intracardiac vortical flow in a human heart is provided including a dual force transducting annular implant comprising laterally extending struts transitioning into annular structural members for positioning on the atrial side of the valve annulus; an anchoring system comprising a therapeutic base plate assembly attachable to the apex of the heart; and a tether assembly comprising a tether connected between the implant and the therapeutic base plate assembly.

DISTAL ANCHOR APPARATUS AND METHODS FOR MITRAL VALVE REPAIR

In some embodiments, an apparatus includes a needle, a pusher, a distal anchor having a distal end, a proximal end, a plurality of radially expandable members between the distal end and the proximal end, and a central bore, and an artificial chordae having a proximal portion and a distal portion terminating in a stopper. The pusher is disposed within a bore of the needle for movement between a delivery position and a deployed position. The distal anchor is disposed within the bore of the needle in a delivery configuration and movable between a delivery position and a deployed position. The artificial chordae is disposed within the bore of the distal anchor with the stopper distal to a distal end of the stopper and the proximal portion proximal to the proximal end of the distal anchor. The distal anchor is reconfigurable from the delivery configuration to a deployed configuration. 1. An apparatus , comprising:a needle having a bore and a distal tip;a pusher having a distal end, the pusher being disposed within the bore of the needle for movement between a delivery position within the needle and a deployed position distal to the distal tip of the needle;a distal anchor having a distal end, a proximal end, a plurality of radially expandable members between the distal end and the proximal end, and a central bore extending between the distal end and the proximal end, the distal anchor being configured to be disposed within the central bore of the needle in a delivery configuration in which the radially expandable members are oriented substantially axially and deployed distally from the needle in a deployed configuration in which the radially expandable members extend radially outwardly from a center of the central bore; anda suture disposed at least partially within the central bore of the distal anchor, the suture having a proximal portion and a distal portion associated with a stopper.2. The apparatus of claim 1 , wherein the distal anchor is reconfigurable from the ...

OCULAR IMPLANTS FOR REDUCTION OF INTRAOCULAR PRESSURE AND METHODS FOR IMPLANTING SAME

Devices and methods for treating intraocular pressure are disclosed. The devices include shunts for draining aqueous humor from the anterior chamber to the uveoscleral outflow pathway, including the supraciliary space and the suprachoroidal space. 150-. (canceled)51. A method for reducing intraocular pressure in an eye of a mammal , comprising:introducing an ocular implant through the anterior chamber of the eye, the ocular implant comprising an elongate outer shell with proximal and distal ends and being shaped to define at least one fluid flow passageway;introducing the implant into eye tissue such that the distal end is in fluid communication with a physiological outflow pathway for ocular fluid and the proximal end is in fluid communication with the anterior chamber of the eye; andejecting from the ocular implant and into the physiological outflow space an expandable material, wherein upon expansion, the expandable material expands in one or more dimensions to create a void in the physiological outflow space more posterior in the eye than the distal end of the implant,wherein aqueous humor is conducted between the proximal and distal ends of the implant and into the physiological outflow space, thereby reducing intraocular pressure andwherein the expandable material is bioerodible.52. The method of claim 51 , wherein the expandable material bioerodes within about 2 weeks to 2.53. The method of claim 51 , wherein the fluid flow passageway comprises one or more inflow portions positioned at or near the proximal end of the implant and at least one outflow portion positioned substantially along a distal portion of the elongate outer shell claim 51 , with at least one outflow portion being at the distal end of the implant.54. The method according to claim 51 , wherein the proximal end is positioned within the anterior chamber of the eye.55. The method according to claim 54 , wherein the distal end is positioned within the physiological outflow space.56. The method ...

SPIRAL-BASED THIN-FILM MESH SYSTEMS AND RELATED METHODS

A spiral-based thin-film mesh for medical devices and related methods is provided. The spiral-based thin-film mesh may be used as a stent cover for a stent device. The thin-film mesh may include a plurality of spirals. The spirals allow the thin-film mesh to expand omni-directionally. In one or more embodiments, the spirals may be logarithmic spirals, golden spirals, approximated golden spirals, box Phi spirals, or Fibonacci spirals. The thin-film mesh may be formed from thin-film Nitinol (TFN), and may be fabricated via sputter deposition on a micropattemed wafer. 1. A thin-film mesh device comprising:a thin-film mesh that comprises a plurality of spirals that are omni-directionally expandable.2. The thin-film mesh device of claim 1 , wherein the plurality of spirals is arranged around an approximate central point on the thin-film mesh.3. The thin-film mesh device of claim 1 , wherein each of the spirals comprises one of three spiral arms claim 1 , four spiral arms claim 1 , six spiral arms claim 1 , twelve spiral arms claim 1 , or twenty-four spiral arms.4. The thin-film mesh device of claim 1 , wherein claim 1 , for each of the spirals claim 1 , a distance between adjacent spiral arms increases as the spiral arms radiate out from a center of the spiral.5. The thin-film mesh device of claim 1 , wherein the thin-film mesh further comprises a plurality of triangular interconnects claim 1 , wherein each of the triangular interconnects connects three of the spirals with one another.6. The thin-film mesh device of claim 1 , wherein each of the spirals is one of a logarithmic spiral claim 1 , a golden spiral claim 1 , an approximated golden spiral claim 1 , a box Phi spiral claim 1 , or a Fibonacci spiral.7. The thin-film mesh device of claim 6 , wherein the box Phi spiral is one of a two box Phi spiral claim 6 , a three box Phi spiral claim 6 , or a four box Phi spiral.8. The thin-film mesh device of claim 1 , wherein the thin-film mesh comprises thin-film Nitinol (TFN ...

INTESTINAL BARRIER SLEEVE RELEASE SYSTEM

An intestinal barrier sleeve release system includes a tubular housing having a first opening at one end and a second opening at the other end. A tubular sleeve to be released is disposed in the housing. A release body connected to the one end of the tubular sleeve is disposed at the first opening of the housing and is made of a material that can be dissolved and absorbed in human intestines. An inner sheath, a middle sheath and an outer sheath are sequentially set and move relative to each other. The inner sheath and the middle sheath are operated to move axially, the release body is disengaged from the housing, and the tubular sleeve moves out of the housing and is released at a specified position of the human intestines. 1. An intestinal barrier sleeve release system , including a tubular housing having a first opening at one end and a second opening at the other end , a folded tubular sleeve to be released disposed in the housing , the intestinal barrier sleeve release system comprising:a release body disposed at the first opening, connected to one end of the tubular sleeve, and made of a material that is able to be dissolved and absorbed in human intestines;a push assembly including an inner sheath, a middle sheath and an outer sheath sequentially set and able to move relative to each other, the inner sheath partially located in the housing and connected to the release body, the middle sheath having a piston stopper in the housing fixedly sleeved on an end, and the outer sheath located outside the housing and having an end fixedly connected to the second opening;wherein the inner sheath and the middle sheath are operated to move axially, the release body is disengaged from the housing, and the tubular sleeve moves out of the housing and is released at a specified position of the human intestines.2. The intestinal barrier sleeve release system according to claim 1 , wherein the release body includes:an internal core having a body portion and a tubular sleeve ...

DELIVERY DEVICE AND METHOD OF DELIVERY

A delivery device can provide sequential delivery of a plurality of intraluminal devices held in a compressed state on the delivery device. Delivery platforms on the delivery device can hold an intraluminal device in a compressed position and be positioned between pusher bands that may also be radiopaque markers. A post deployment dilation device can be included. The post deployment dilation device can be a plurality of expansion filaments, a bellows, or a balloon. An intravascular device deployment method can include allowing a self-expanding intravascular device to expand, aligning the post deployment dilation device under the intravascular device, and causing the post deployment dilation device to expand radially to push outward on the intravascular device. 1. A delivery device comprising:an inner shaft configured to receive a self-expanding intraluminal device for deployment from the delivery device into a vessel;an outer sheath positioned about at least a portion of the inner shaft and movable with respect to at least a portion of the inner shaft, the outer sheath having a pre-deployment position in which the self-expanding intraluminal device is at least substantially covered and at least one delivery position in which the self-expanding intraluminal device is uncovered to release the self-expanding intraluminal device from the delivery device; and a balloon attached to the outer sheath of the delivery device, the balloon having a pre-actuated configuration having a pre-deployment diameter and an actuated configuration having a deployment diameter larger than the pre-deployment diameter;', 'at least one inflation fluid lumen in fluid communication with the balloon and extending along at least a portion of the outer sheath;, 'a post deployment dilation device comprisingwherein the post deployment dilation device is configured to apply a radial force to an inner surface of the self-expanding intraluminal device after deployment of the self-expanding intraluminal ...

SYSTEM FOR CONNECTING A MEDICAL IMPLANT TO AN INSERTION AID

The invention relates to a system for connecting a medical implant to an insertion aid, comprising: a first spiral connecting device at the proximal end of the medical implant, a second spiral connecting device at the distal end of the insertion aid, a core wire, which in a first operating state of the system fixes the first spiral connecting device and the second spiral connecting device in relation to one another, wherein in the first operating state the first spiral connecting device and the second spiral connecting device at least partially engage in one another and the core wire extends through the first spiral connecting device and the second spiral connecting device. 1. A system for connecting a medical implant to an insertion aid comprising:a first helical connecting member at the proximal end of the medical implant;a second helical connecting member at the distal end of the insertion aid;a core wire, which in a first operating state of the system locks the first helical connecting member and the second helical connecting member relative to each other; andwherein in the first operating state the first helical connecting member and the second helical connecting member at least partially engage each other and the core wire extends through the first helical connecting member and the second helical connecting member.2. The system according to claim 1 , wherein the insertion aid is a spiral claim 1 , wherein the single turns of the spiral outside the first helical connecting member are preferably located directly adjacent to each other.3. The system according to claim 1 , wherein the medical implant is a spiral claim 1 , wherein the single turns of the spiral outside the second helical connecting member are preferably at least partly located adjacent to each other.4. The system according to claim 1 , wherein the single turns of the first helical connecting member and/or the second helical connecting member are spaced from each other.5. The system according to ...

OVAL STENT

A stent comprises an elastically deformable stent wall forming a lumen extending between a first opening and a second opening of the stent. The stent wall is configured to be percutaneously delivered into a blood vessel, secure to a blood vessel wall of a blood vessel, and radially expand from a first configuration to a second configuration within the blood vessel into direct contact with the blood vessel wall. The first configuration defines a first major dimension, a first minor dimension, a first cross-sectional area, a first cross-sectional shape, and a first perimeter of the stent wall. The second configuration defines a second major dimension, a second minor dimension that is greater than the first minor dimension, a second cross-sectional area that is greater than the first cross-sectional area, and the first perimeter of the stent wall. 1. A stent comprising: be percutaneously delivered into a blood vessel;', 'secure to a blood vessel wall of a blood vessel; and', 'radially expand from a first configuration to a second configuration within the blood vessel into direct contact with the blood vessel wall, the first configuration defining a first major dimension, a first minor dimension, a first cross-sectional area, a first cross-sectional shape, and a first perimeter of the stent wall, and the second configuration defining a second major dimension, a second minor dimension that is greater than the first minor dimension, a second cross-sectional area that is greater than the first cross-sectional area, and the first perimeter of the stent wall., 'an elastically deformable stent wall forming a lumen extending between a first opening and a second opening of the stent, the stent wall being configured to2. The stent of claim 1 , wherein the first major dimension is greater than the second major dimension.3. The stent of claim 1 , wherein the first cross-sectional shape comprises an oval shape.4. The stent of claim 1 , wherein the first cross-sectional shape ...

ASSEMBLY FOR REPLACING THE TRICUSPID ATRIOVENTRICULAR VALVE

The present invention relates to an assembly for the tricuspid orifice of a human heart, comprising an external frame () connected to an internal stent () carrying a tricuspid valve bioprosthesis () and a sealing skirt (). The external frame () is configured to hold its position in the native tricuspid annulus. The internal stent () is connected to the external frame by one or more fixing strands. The sealing skirt () covers the interstitial space existing between the external frame () and the internal stent (). Developments are described which comprise in particular the use of a deformable region of the frame, various alternative embodiments of the sealing skirt, the use of a frame composed of multiple sub-sections, the use of fixing strands between the stent and the frame and of fixing elements for fixing the assembly to the native tissue, the use of sensors and/or actuators, and also the use of a stent in the inferior vena cava. Method aspects are described. 1. An assembly for the tricuspid orifice of the right heart of a human heart , comprising:{'b': '100', 'an external frame () connected to'}{'b': '200', 'an internal stent () carrying'}{'b': '210', 'a tricuspid valve bioprosthesis () and'}{'b': '610', 'a sealing skirt (),'}wherein{'b': '100', 'the external frame () is configured to hold its position in the native tricuspid annulus;'}{'b': '200', 'the internal stent () is connected to the external frame by one or more fixing strands; and'}{'b': 610', '100', '200, 'the sealing skirt () covers the interstitial space existing between the external frame () and the internal stent (); and'}{'b': 610', '100, 'wherein the sealing skirt () is configured to obstruct the contact space between the external frame () and the site of the native tissue in the region of the native tricuspid annulus.'}2100. The assembly as claimed in one of the preceding claims , wherein the external frame () has a deformable region configured to hold the assembly in position inside the native ...

JUGULAR FEMORAL VENA CAVA FILTER SYSTEM

An embolus filter introducer system has a symmetric introducer sheath with a filter inside. The introducer sheath can be attached at either end to a deployment actuator. The deployment actuator can thereby be used to push the filter out of the introducer sheath. Since the sheath can be oriented in a selectable direction, so can the filter, allowing the sheath to be introduced via a jugular or femoral approach to the vena cava. 1. An embolus filter delivery device for delivering an embolus filter to a delivery site within a human living host , comprising:a) a pusher assembly having a frame and a pusher member movable with respect to the frame, the pusher assembly having a pusher assembly end portion with a pusher assembly connector;b) an introducer sheath having an inner lumen and that is configured to be inserted into a circulatory system of a human living host, said sheath having first and second opposed sheath ends;c) first and second removable seals on the introducer sheath in a sheath initial position wherein the first seal is attached to the first sheath end and the second seal is attached to the second sheath end;d) with an embolus filter housed in said lumen in between said sheath seals and ends in said sheath initial position, wherein in said sheath initial position one sheath end has a first sheath end connector and the second sheath end has a second sheath end connector, each end connector enabling connection of a said sheath end to the pusher assembly frame at the pusher assembly connector;e) wherein in said sheath initial position either of said first and second sheath end connectors is selectively connectable to the pusher assembly connector;f) wherein a connection of the pusher assembly to the first sheath end enables the pusher member to push the filter out of the second sheath end;g) wherein in said sheath initial position each sheath end including said sheath end connector is sized and shaped to be insertable into the circulatory system of the human ...

Configurable Intervertebral Implant

The present disclosure relates to a surgical device, such as a surgical implant, which may be used in several types of procedures. More specifically, the present disclosure relates to implants for use in an anterior, posterior, posterior lateral or direct lateral approach to the disc space. The surgical device may be manipulated in various manners to accommodate delivery through a minimally invasive portal in one configuration and adjusted to a second configuration once placed in the intervertebral space. A delivery system for placing the surgical device in a body is also disclosed. 1. A surgical device for insertion in an intervertebral space between adjacent vertebrae , the device comprising:a first module including a bore;an armature slidingly engagable in the bore of the first module, wherein the armature can be introduced at least partially into the bore during a surgical procedure; anda second module connectable to a distal end of the armature, wherein the surgical device has an adjustable configuration achieved by adjustment of the position of the armature within the bore of the first module, and wherein the second module can be interconnected to the armature during the surgical procedure.2. The surgical device of claim 1 , wherein the armature is rotatably adjustable in the bore of the first module.3. The surgical device of claim 1 , wherein the armature is adapted to be adjusted after insertion of the surgical device in the intervertebral space to extend the surgical device across a portion of the disc space to provide bi-lateral support to the adjacent vertebrae.4. The surgical device of claim 1 , wherein the surgical device includes a stop to maintain the armature and the second module in a desired position.5. The surgical device of claim 4 , wherein the stop comprises an aperture of the first module adapted to receive a threaded fixture that can be rotated to apply a force to the armature.6. The surgical device of claim 1 , further comprising an aperture ...

SELF-CURVING STENT-GRAFT

An endovascular self-curving stent-graft () includes a self-curving longitudinal portion (), which is curved so as to define an innermost curve () and an outermost curve (), when the stent-graft () is unconstrained in a radially-expanded state. The stent-graft () includes a plurality of circumferential strut members (); a compression-generation spring (), which (a) is in an elongated configuration when the stent-graft () is in a radially-compressed state, and (b) overlaps respective first portions () of at least two of the circumferential strut members (); and an anti-buckling spring (), which overlaps respective second portions () of at least two of the circumferential strut members (). The anti-buckling spring () and the compression-generation spring () are together configured to curve the self-curving longitudinal portion () when the stent-graft () is unconstrained in the radially-expanded state, such that a lesser length of the self-curving longitudinal portion (), measured along the innermost curve (), is less than 80% of a greater length of the self-curving longitudinal portion (), measured along the outermost curve (). 1. Apparatus comprising a generally tubular endovascular self-curving stent-graft , which (a) comprises a self-curving longitudinal portion having proximal and distal ends , (b) is configured to transition from a radially-compressed delivery state to a radially-expanded state , wherein , when the stent-graft is unconstrained in the radially-expanded state , the self-curving longitudinal portion of the stent-graft is curved so as to define an innermost curve and an outermost curve , and (c) comprises:a plurality of circumferential strut members, disposed at respective axial positions along the self-curving longitudinal portion of the stent-graft, surrounding a central longitudinal axis of the self-curving longitudinal portion of the stent-graft;a graft member, which comprises one or more substantially blood-impervious flexible sheets, and which ...

PROSTHETIC HEART VALVE DEVICES AND ASSOCIATED SYSTEMS AND METHODS

The present technology is a prosthetic heart valve device, and related systems and methods, for treating a native valve of a human heart having a native annulus and native leaflets. One embodiment comprises a valve support, a prosthetic valve assembly within the valve support, and an anchoring member. The device further includes an extension member coupled to the anchoring member and having an annular first portion coupled to the anchoring member and a second portion coupled to the first portion. The extension member is folded in a delivery configuration such that the first portion overlaps the second portion. When released from the a delivery catheter, the extension member unfolds such that the first portion extends radially outwardly from the anchoring member and the second portion extends radially outwardly from the first portion. 115.-. (canceled)16. A method for deploying a prosthetic heart valve device , the method comprising:positioning a distal portion of a delivery catheter at a native heart annulus;delivering a prosthetic heart valve device to the distal portion of the delivery catheter, the prosthetic heart valve device having an extension member configured to be positioned at an upstream side of the annulus when the device is deployed, and wherein the extension member includes an annular first portion and a second portion coupled to the first portion, wherein during delivery, the second portion is folder back towards the first portion; andwithdrawing the delivery catheter proximally thereby allowing the extension member to unfold such that the extension member extends laterally away from a central longitudinal axis of the prosthetic heart valve device.17. The method of wherein withdrawing the delivery catheter proximally allows the extension member to unfold such that (a) a distal end of the first portion moves radially away from the central longitudinal axis of the device claim 16 , and (b) a distal end of the second portion moves radially towards the ...

STRAIN-RELIEVING SLEEVE FOR CARDIOVASCULAR DEVICES

An actuator sleeve includes resiliency features that may reduce chronic strain on valve annulus implants. The resiliency features may relate to one or more of a material, a manufacture, a dimension, and/or design attribute of the sleeve. In one aspect the resiliency features may allow deformation of the sleeve at frame interfaces to distribute forces to reduce the frame fatigue. 1. An implant comprising:a frame having a proximal end, a distal end and adjacent struts joined at an apex; anda sleeve disposed about the apex, the sleeve configured to apply a force to the frame at one or more contact points, the sleeve including a resiliency feature selected to reduce stress resulting from the force at the one or more contact points.2. The implant of claim 1 , wherein the sleeve is comprised of a sleeve material including one or more of nitinol claim 1 , stainless steel and cobalt chrome and the sleeve material varies in resistance along a length of the sleeve.3. The implant of claim 2 , wherein the sleeve comprises a sleeve body having a bore extending therethrough claim 2 , and the sleeve comprises a first material disposed within the bore and a second material disposed at least partially around the bore claim 2 , the first material and the second material having different elasticities.4. The implant of claim 3 , wherein the first material coats at least a portion of the bore proximate to at least one contact point.5. The implant of claim 4 , wherein the first material comprises a bumper.6. The implant of claim 1 , wherein the sleeve includes a sleeve slot extending proximally from a distal end of the sleeve for a slot extent.7. The implant of claim 6 , wherein the sleeve slot varies in width over the slot extent.8. The implant of claim 7 , wherein a width of the sleeve slot is greater than half a width of the sleeve.9. The implant of claim 6 , wherein the sleeve slot extends linearly along the sleeve or helically around the sleeve for the slot extent.10. The implant of ...

DEVICE AND METHOD FOR TREATING VASCULAR INSUFFICIENCY

Embodiments of a leaflet clip device and method of reducing regurgitation through a native heart valve are disclosed. A leaflet clip device can include an elongated clipping member having a first end portion and a second end portion and a tensioning mechanism coupled to the clipping member. The leaflet clip device can further include one or more tensioning members disposed within a lumen of the clipping member, wherein the one or more tensioning members are operatively connected to the tensioning mechanism to transform the clipping member from a delivery configuration to an implantation configuration. 1. A leaflet clip device , comprising:an elongated clipping member having a first end portion and a second end portion;a tensioning mechanism coupled to the clipping member; andone or more tensioning members disposed within a lumen of the clipping member, wherein the one or more tensioning members are operatively connected to the tensioning mechanism to transform the clipping member from a delivery configuration to an implantation configuration.2. The leaflet clip device of claim 1 , further comprising a retaining mechanism disposed within the lumen of the clipping member claim 1 , wherein the retaining mechanism retains the shape of the clipping member in the implantation configuration.3. The leaflet clip device of claim 1 , wherein the clipping member comprises a shape memory material.4. The leaflet clip device of claim 1 , wherein the tensioning mechanism is centrally coupled to the clipping member with respect to the first end portion and the second end portion.5. The leaflet clip device of claim 1 , wherein the one or more tensioning members comprises:a first tensioning member fixed at a distal end portion thereof to the first end portion of the clipping member and operatively connected to the tensioning mechanism at a proximal end portion of the first tensioning member; anda second tensioning member fixed at a distal end portion thereof to the second end portion ...

Biodegradable endoprostheses and methods of their fabrication

A biodegradable stent prosthesis formed from a degradable material, having a plurality of luminal, abluminal, and side surface regions, wherein a surface portion extending between the abluminal and luminal surface region of at least some structural elements is convex.

Devices for Insertion into a Vertebral Body and Methods of Treating a Vertebral Body

Spinal tissue distraction devices that include a member which has a pre-deployed configuration for insertion between tissue layers and a deployed configuration in which the member, by change of configuration, forms a support structure for separating and supporting layers of spinal tissue.

ENDOGRAFT VISUALIZATION WITH PRE-INTEGRATED OR REMOVABLE OPTICAL SHAPE SENSING ATTACHMENTS

An endograft () includes a stent structure. An optical shape sensing (OSS) system () is associated with the endograft and is configured to measure shape, position and/or orientation of the stent structure. The OSS system () is connected to the stent structure and removable in a plurality of ways. Methods for deployment and removal of the OSS system are also provided. 1. An endograft , comprising:a stent structure;at least one attachment mechanism configured to releasably attach to the stent structure; andat least one optical shape sensing (OSS) system having one or more optical fibers, wherein said optical shape sensing system is coupled to the at least one attachment mechanism and is configured to measure at least one of shape, position or orientation of the stent structure.2. The endograft as recited in claim 1 , wherein the at least one attachment mechanism includes a hook claim 1 , a clip claim 1 , a clamp claim 1 , a magnet and a capture tube.3. The endograft as recited in claim 1 , wherein the at least one attachment mechanism is coupled at a distal end of the at least one OSS system.4. The endograft as recited in claim 1 , wherein the at least one attachment mechanism attached to the stent structure at attachment point of a geometric landmark.5. The endograft as recited in claim 4 , wherein the attachment point includes one or more of a ring of the endograft claim 4 , a fenestration claim 4 , a scallop or a bifurcation junction.6. The endograft as recited in claim 1 , wherein the at least one attachment mechanism is selectively releasable from the stent structure.7. The endograft as recited in claim 1 , wherein the at least one attachment mechanism includes a plurality of attachment points on the stent structure for a same OSS system.8. An endograft claim 1 , comprising:a stent structure;at least one deployable instrument pre-cannulated through a fenestration in the stent structure; andthe at least one deployable instrument including an optical shape sensing ...

Percutaneous repair of mitral prolapse

A mitral valve leaflet repair system may include a delivery catheter having at least one lumen extending proximally from a distal end of the delivery catheter, a plurality of anchor elements disposed within the at least one lumen, each of the plurality of anchor elements being configured to extend through one layer of mitral valve leaflet tissue, and a securing element configured to secure at least two of the plurality of anchor elements together on one side of the mitral valve leaflet tissue. The at least one lumen may include a suction lumen configured to grasp a mitral valve leaflet prior to extending the plurality of anchor elements through one layer of mitral valve leaflet tissue.

THROMBUS ASPIRATION WITH DIFFERENT INTENSITY LEVELS

Vascular treatment devices and methods include a woven structure including a plurality of bulbs that may be self-expanding, a hypotube, for example including interspersed patterns of longitudinally spaced rows of kerfs, and a bonding zone between the woven structure and the hypotube. The woven structure may include patterns of radiopaque filaments measureable under x-ray. Structures may be heat treated to include various shapes at different temperatures. The woven structure may be deployable to implant in a vessel. A catheter may include a hypotube including interspersed patterns of longitudinally spaced rows of kerfs and optionally a balloon. Laser cutting systems may include fluid flow systems. 1. A system for facilitating aspiration of a thrombus in a vessel , the system comprising:an automated motor pump configured to facilitate aspiration of the thrombus, the automated motor pump comprising an external control panel configured to receive input from an operator; andpower electronics configured to power and control the automated motor pump to generate a plurality of suction patterns having a plurality of intensity levels, a first intensity level having a first negative pressure between 100 and 350 mm Hg;', 'a second intensity level having a second negative pressure between 351 and 550 mm Hg; and', 'a third intensity level having a third negative pressure between 551 and 769 mm Hg; and, 'wherein the plurality of intensity levels compriseswherein a first crescendo suction pattern of the plurality of suction patterns comprises a repetitive cycle comprising the first intensity level for a first duration, the second intensity level for a second duration after the first duration, and the third intensity level for a third duration after the second duration.2. The system of :wherein the first duration, the second duration, and the third duration are each between 1 and 30 seconds; andwherein a total duration of the repetitive cycle of the first crescendo suction pattern ...

THROMBUS ASPIRATION USING AN OPERATOR-SELECTABLE SUCTION PATTERN

Vascular treatment devices and methods include a woven structure including a plurality of bulbs that may be self-expanding, a hypotube, for example including interspersed patterns of longitudinally spaced rows of kerfs, and a bonding zone between the woven structure and the hypotube. The woven structure may include patterns of radiopaque filaments measureable under x-ray. Structures may be heat treated to include various shapes at different temperatures. The woven structure may be deployable to implant in a vessel. A catheter may include a hypotube including interspersed patterns of longitudinally spaced rows of kerfs and optionally a balloon. Laser cutting systems may include fluid flow systems. 1. A system for facilitating aspiration of a thrombus in a vessel using an operator-selectable suction pattern , the system comprising:an automated motor pump configured to facilitate aspiration of the thrombus, the automated motor pump comprising an external control panel configured to receive input from an operator; andpower electronics configured to power and control the automated motor pump to generate a plurality of variable suction patterns having a plurality of intensity levels, a first intensity level having a first negative pressure; and', 'a second intensity level having a second negative pressure,', 'wherein the first negative pressure is between 551 and 769 mm Hg, and', 'wherein the first negative pressure is more negative than the second negative pressure;, 'wherein the plurality of intensity levels compriseswherein a first variable suction pattern of the plurality of variable suction patterns comprises a repetitive cycle comprising the first intensity level for a first duration and the second intensity level for a second duration after the first duration,wherein the first duration and the second duration are each between 1 and 30 seconds, andwherein a total duration of the repetitive cycle of the first variable suction pattern is between 1 minute and 15 ...

PROSTHETIC HEART VALVE DEVICES AND ASSOCIATED SYSTEMS AND METHODS

The present technology is a prosthetic heart valve device, and related systems and methods, for treating a native valve of a human heart having a native annulus and native leaflets. One embodiment comprises a valve support, a prosthetic valve assembly within the valve support, and an anchoring member having an upstream portion and a downstream portion. The device further includes an extension member coupled to the fixation frame and extending radially outward therefrom. The extension member includes a plurality of wires, at least a portion of which include an inner core surrounded by an outer material. The wires include a plurality of recesses extending through at least a portion of the thickness of the outer material, and a therapeutic agent in the recesses for delivery to the anatomy when the prosthetic heart valve device is positioned at a native annulus. 1. A prosthetic heart valve device comprising:an anchoring member having an annular fixation frame with an upstream portion and a downstream portion;a tubular valve support having a first portion coupled to the downstream portion of the fixation frame and a second portion spaced radially inward from the upstream portion of the fixation frame;a valve assembly coupled to the valve support and having at least one leaflet movable from a closed position in which blood flow is blocked through the valve support and an open position in which blood flow is allowed through the valve support in a downstream direction; andan extension member coupled to the fixation frame and extending radially outward therefrom, wherein the extension member includes a plurality of wires, wherein at least a portion of the wires include an inner core surrounded by an outer material, and wherein (a) the inner core is a first material, (b) the outer material is a second material different than the first material and has a thickness, (c) the wires include a plurality of recesses extending through at least a portion of the thickness of the outer ...

PROSTHETIC HEART VALVE DEVICES AND ASSOCIATED SYSTEMS AND METHODS

The present technology is a prosthetic heart valve device, and related systems and methods, for treating a native valve of a human heart having a native annulus and native leaflets. One embodiment comprises a valve support, a prosthetic valve assembly within the valve support, and an anchoring member. The device further includes an extension member coupled to the anchoring member and having an annular first portion coupled to the anchoring member and a second portion coupled to the first portion. The extension member is folded in a delivery configuration such that the first portion overlaps the second portion. When released from the a delivery catheter, the extension member unfolds such that the first portion extends radially outwardly from the anchoring member and the second portion extends radially outwardly from the first portion. 1. A prosthetic heart valve device comprising:an anchoring member having an annular fixation structure with an upstream portion and a downstream portion;a tubular valve support having a first portion coupled to the upstream portion of the anchoring member and a second portion spaced radially inward from the upstream portion of the anchoring member;a valve assembly coupled to the valve support and having at least one leaflet movable from a closed position in which blood flow is blocked through the valve support and an open position in which blood flow is allowed through the valve support in a downstream direction; and the extension member folds back on itself in a delivery configuration such that the first portion extends distally from the fixation structure and the second portion extends back proximally from the first portion, and', 'when the extension member is in a deployed configuration, the first portion extends radially outwardly from the fixation structure and the second portion extends radially outwardly from the first portion., 'an extension member having an annular first portion coupled to the fixation structure and a second ...

MEDICAL DEVICE FOR TREATING A HEART VALVE INSUFFICIENCY

A medical device for treating a heart valve insufficiency, with an endoprosthesis which can be introduced into a patient's body and expanded to secure a heart valve prosthesis in the patient's aorta. In an embodiment, the endoprosthesis has a plurality of positioning arches configured to be positioned with respect to a patient's aorta and a plurality of retaining arches to support a heart valve prosthesis. The endoprosthesis includes a first collapsed mode during the process of introducing it into the patient's body and a second expanded mode when it is implanted. 121-. (canceled)22. A method of treating a native heart valve , the method comprising:positioning a plurality of first arches of an endoprosthesis relative to the native heart valve by placing an apex of each first arch within a respective pocket of the native heart valve, each first arch having an open end opposite the apex and joined to an open end of an adjacent first arch; andpositioning a plurality of second arches of the endoprosthesis radially inward of the plurality of first arches, such that the native heart valve is positioned radially inward of at least a portion of the plurality of first arches and radially outward of at least a portion of the plurality of second arches;wherein the endoprosthesis includes a prosthetic valve attached to the plurality of second arches, and at least part of the prosthetic valve extends from the plurality of second arches transversely across an interior of the endoprosthesis.23. The method of claim 22 , wherein the endoprosthesis comprises a shape-memory material.24. The method of claim 22 , wherein the endoprosthesis is self-expandable.25. The method of claim 22 , wherein positioning the plurality of first arches includes expanding the plurality of first arches while the plurality of second arches is in a collapsed state.26. The method of claim 22 , wherein positioning the plurality of second arches includes applying radial force against the plurality of first ...

MEDICAL DEVICE, KIT AND METHOD FOR CONSTRICTING TISSUE OR A BODILY ORIFICE, FOR EXAMPLE, A MITRAL VALVE

A device, kit and method may employ an implantable device (e.g., annuloplasty implant) and a tool to implant such. The implantable device is positionable in a cavity of a bodily organ (e.g., a heart) and operable to constrict a bodily orifice (e.g., a mitral valve). Tissue anchors are guided into precise position by an intravascularly deployed anchor guide frame and embedded in an annulus. Constriction of the orifice may be accomplished via a variety of structures, for example by cinching a flexible cable or anchored annuloplasty ring, the cable or ring attached to the tissue anchors. The annuloplasty ring may be delivered in a generally elongated configuration, and implanted in an anchored generally arch, arcuate or annular configuration. Such may move a posterior leaflet anteriorly and an anterior leaflet posteriorly, improving leaflet coaptation to eliminate mitral regurgitation. 1. (canceled)2. An implant system comprising:a helical tissue anchor comprising a plurality of helically arranged coils, the helical tissue anchor configured to be implanted into bodily tissue within a body; andan anchor guide member configured to position the helical tissue anchor at least proximate a tissue insertion location within the body during an implant procedure, the anchor guide member including a first portion and a second portion, the first portion of the anchor guide member located within multiple coils of the plurality of helically arranged coils of the helical tissue anchor at least in a first configuration of the implant system, and the second portion of the anchor guide member extending radially outward beyond the helical tissue anchor at least in the first configuration of the implant system,wherein, at least in the first configuration, the helical tissue anchor is configured to rotate relative to both the first portion of the anchor guide member and the second portion of the anchor guide member, andwherein the first configuration of the implant system is configured to ...

LAYERED MEDICAL APPLIANCES AND METHODS

Medical appliances may be formed of multilayered constructs. The layers of the constructs may be configured with various physical properties or characteristics. The disposition and arrangement of each layer may be configured to create an overall construct with a combination of the individual properties of the layers. Constructs may be used to create vascular prostheses or other medical devices. 1. (canceled)3. The multilayered vascular prosthesis of claim 2 , wherein the axis of longitudinal expansion of at least one of the ePTFE sublayers is disposed at an angle between 0 degrees and 90 degrees to the axis of longitudinal expansion of at least one adjacent ePTFE sublayer.4. The multilayered vascular prosthesis of claim 2 , wherein the axis of longitudinal expansion of at least one of the ePTFE sublayers is perpendicular to the axis of longitudinal expansion of at least one adjacent ePTFE sublayer.5. The multilayered vascular prosthesis of claim 2 , wherein the axis of longitudinal expansion of at least one of the ePTFE sublayers is at an angle to a longitudinal axis of the multilayered vascular prosthesis.6. The multilayered vascular prosthesis of claim 2 , wherein at least one of the ePTFE sublayers is configured to be impermeable to red blood cell migration.7. The multilayered vascular prosthesis of claim 6 , wherein an average pore size of at least one of the ePTFE sublayers is different than an average pore size of at least one adjacent ePTFE sublayer.8. The multilayered vascular prosthesis of claim 6 , wherein pores of at least one of the ePTFE sublayers are misaligned with pores of at least one adjacent ePTFE sublayer such that a tortuous path is defined between the pores of the sublayers.9. The multilayered vascular prosthesis of claim 6 , wherein at least one of the ePTFE sublayers is coupled to a non-porous layer.10. A multilayered vascular prosthesis claim 6 , comprising:a luminal surface comprising a serially deposited fiber layer; andan expanded ...

DELIVERY DEVICE AND METHOD OF DELIVERY

A delivery device can provide sequential delivery of a plurality of intraluminal devices or tacks held in a compressed state on the delivery device. Delivery platforms on the delivery device can hold a tack in a compressed position and be positioned between annular pusher bands that may also be radiopaque markers. The annular pusher bands can be made of wire or sections of material to increase flexibility while remaining radiopacity. A post deployment dilation device can be included. The post deployment dilation device can be a plurality of expansion filaments, a bellows, or a balloon. A tack deployment method can include allowing a self-expanding tack to expand, aligning the post deployment dilation device under the tack, and causing the post deployment dilation device to expand radial to push outward on the tack. 2. The delivery device of claim 1 , wherein the delivery platform comprises a plurality of expansion filament recesses claim 1 , wherein each expansion filament of the plurality of expansion filaments is paired with one expansion filament recess of the plurality of expansion filament recesses.3. The delivery device of claim 1 , wherein the plurality of expansion filaments are configured to lie within the plurality of expansion filament recesses when in the pre-actuated position such that the plurality of expansion filaments lie substantially below the surface of the deployment platform.4. The delivery device of claim 1 , wherein the plurality of expansion filament recesses transition to a plurality of expansion filament lumens substantially at the proximal end of the delivery platform.5. The delivery device of claim 1 , wherein the first end is a distal end of each expansion filament of the plurality of expansion filaments that is fixed at a distal end of the deployment platform.6. The delivery device of claim 5 , wherein a proximal end of each expansion filament of the plurality of expansion filaments is configured to be pushed distally and cause radial ...

DEVICE FOR DELIVERING GRAFTS AT A SURGICAL SITE AND METHOD

A device and method for delivering a synthetic mesh or graft for anatomical repair at a defect site. A plurality of flexible arms is connected to the synthetic mesh or graft. Grasping jaws are individually controlled at or near a proximal end of the device for connection of the graft and release of the graft at the surgical site. The flexible arms, with graft attached are positioned through a surgical incision to the defect site. An actuator positions the flexible arms to assume a radial array at the surgical site, unfolding and spreading the graft for attachment. The length of each flexible arm is individually adjustable to adapt to the size and shape of the graft selected for installation at the defect site to repair the defect. 2. A device for delivery of a graft for attachment to tissue as described in claim 1 , wherein each of the flexible arms of the plurality of flexible arms is slidable relative to the first actuator and a length of each of the flexible arms extends from the housing and the length of each of the flexible arms of the plurality of flexible arms that extends from the housing is individually adjustable.3. A device for delivery of a graft for attachment to tissue as described in claim 1 , further comprising a brake claim 1 , wherein each of the plurality of flexible arms frictionally engages the brake.4. A device for delivery of a graft for attachment to tissue as described in claim 1 , further comprising a brake claim 1 , wherein the brake comprises a plurality of channels formed therein claim 1 , and each of the plurality of flexible arms frictionally engages a channel of the plurality of channels of the brake.5. A device for delivery of a graft for attachment to tissue as described in claim 1 , wherein a portion of each of the flexible arms is slidable into a chamber of the housing claim 1 , and wherein the first actuator is contained in the housing.6. A device for delivery of a graft for attachment to tissue as described in claim 1 , wherein ...

MEDICAL DEVICE FOR BREAST SURGERY

A device is initially rolled up can unfold into its original spherical dome shape after insertion through a surgical incision. 1. A medical device for breast surgery said medical device originally constituted by a quadratic matrix of hemispherical or paraboloid or ellipsoid or hyperboloid shape , said quadratic matrix having a three-dimensional development , said matrix being rolled to obtain a solid of revolution said solid of revolution having a central section greater than the distal sections and said solid of revolution being tapered at the extremities.2. Medical device according to wherein it is equipped with a restraint device.3. Medical device according to claim 1 , wherein the quadratic matrix is made of collagen membrane having shape memory.4. Medical device according to claim 1 , wherein the restraint device is in biomaterial.5. Medical device according to claim 1 , wherein once inserted in a surgical wound the solid of revolution returns at the original hemispherical or paraboloid or ellipsoid or hyperboloid shape.6. Medical device according to claim 2 , wherein the quadratic matrix is made of collagen membrane having shape memory.7. Medical device according to claim 2 , wherein the restraint device is in biomaterial.8. Medical device according to claim 3 , wherein the restraint device is in biomaterial.9. Medical device according to claim 6 , wherein the restraint device is in biomaterial.10. Medical device according to claim 2 , wherein once inserted in a surgical wound the solid of revolution returns at the original hemispherical or paraboloid or ellipsoid or hyperboloid shape.11. Medical device according to claim 3 , wherein once inserted in a surgical wound the solid of revolution returns at the original hemispherical or paraboloid or ellipsoid or hyperboloid shape.12. Medical device according to claim 4 , wherein once inserted in a surgical wound the solid of revolution returns at the original hemispherical or paraboloid or ellipsoid or hyperboloid ...

TRANSCATHETER HEART VALVE APPARATUS FOR CALCIFIC MITRAL STENOSIS

Examples of a mitral heart valve apparatus are described. In one example, the apparatus has an annular body made of a first material, and a plurality of first anchor members and at least two paddles made of a second material extending from the annular body. In a compressed state, the first anchor members extend substantially longitudinally from the first end of the annular body, and GC the paddles extend substantially longitudinally from the second end of the annular body. In an expanded state, the annular body has a larger diameter, the first anchor members extend outward from the first end for engaging an upstream portion of a mitral valve annulus to resist displacement of the annular body towards a left ventricle, and the paddles extend outward from the second end for engaging 2. The apparatus of claim 1 , further comprising a plurality of second anchor members made from the second material and extending from the second end of the annular body claim 1 , wherein claim 1 , in the compressed state claim 1 , the plurality of second anchor members extend substantially longitudinally from the first end of the annular body claim 1 , and wherein claim 1 , in the expanded state claim 1 , the plurality of second anchor members extend longitudinally and radially outward from the second end of the annular body for engaging a subvalvular apparatus to resist displacement of the annular body towards a left atrium.3. The apparatus of claim 2 , wherein an average length of the plurality of first anchor members is larger than an average length of the plurality of second anchor members.4. The apparatus of claim 3 , wherein at least some of the plurality of second anchor members are hook-shaped.5. The apparatus of claim 1 , wherein the plurality of first anchor members are welded to the annular body claim 1 , and wherein the at least two paddles are welded to the annular body.6. The apparatus of claim 1 , wherein the annular body comprises a plurality of diamond shaped openings.7. ...

Stent Assembly For Use in Prosthetic Heart Valves

A prosthetic heart valve having a cuff attached to a stent provides a seal for preventing paravalvular leakage. The cuff may be constructed from known sealing materials to fill in and around paravalvular leakage gaps, while continuously collapsing down into a low profile volume within the stent. The cuff has a first cuff portion positioned on the luminal surface of the stent and a second cuff portion. The second cuff portion has a deployed configuration in which a region of the second cuff portion is spaced from the abluminal surface of the stent and an initial configuration different from the deployed configuration.

TISSUE SHAPING DEVICE

An anchor anchors a therapeutic device having an elongated body within a body lumen. The anchor includes a fixation member carried on the device which is adjustable from a first configuration that permits placement of the device in the body lumen to a second configuration that anchors the device within the body lumen. The anchor further includes a lock that locks the fixation member in the second configuration. The fixation member may be locked in any one of a plurality of intermediate points between the first configuration and a maximum second configuration. 1. A mitral valve therapy device comprising:a distal expandable anchor, a proximal expandable anchor, and a connecting member extending between the distal expandable anchor and the proximal expandable anchor,the distal expandable anchor having a distal expanded configuration and the proximal expandable anchor having a proximal expanded configuration,wherein the distal anchor includes a distal expandable member and a proximal expandable member, the distal expandable member coupled to the proximal expandable member.2. The device of claim 1 , wherein the distal expandable member extends from a distal anchor distal end to a distal anchor apex claim 1 , and wherein the proximal expandable member extends from the distal anchor apex to a distal anchor proximal end.3. The device of claim 1 , wherein the distal expandable member is coupled to the proximal expandable member at a distal anchor apex.4. The device of claim 1 , wherein a distal end of the proximal expandable member is coupled to proximal end of the distal expandable member.5. The device of claim 4 , wherein the distal end of the proximal expandable member is coupled to the proximal end of the distal expandable member at an apex of the distal anchor.6. The device of claim 1 , wherein the distal expandable member has a hoop configuration claim 1 , to which a distal end of the proximal expandable member is attached.7. The device of claim 1 , wherein the distal ...

IN-SITU FORMED INTERVERTEBRAL FUSION DEVICE AND METHOD

An orthopedic device for implanting between adjacent vertebrae comprising: an arcuate balloon and a hardenable material within said balloon. In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means. 1. (canceled)2. An expandable spinal fusion implant , comprising:a) an upper endplate having an upper surface configured to engage bone and a lower surface;b) a lower endplate having a lower surface configured to engage bone and an upper surface;c) a core having a first mating surface that mates with the upper endplate via a slidable guide-track and a second mating surface that mates with the lower endplate via a slidable guide-track; andd) an elongate metallic element extending longitudinally through the core;wherein the core includes an upper ramp component having a first ramped surface and a lower ramp component having a second ramped surface opposing the first ramped surface, andwherein longitudinal translation of the ramped surfaces increases a height between the upper surface of the upper endplate and the lower surface of the lower endplate.3. The implant of claim 2 , wherein the upper and lower endplates and the core are each arcuate in a plane parallel to their length4. The implant of claim 2 , wherein a cross-section taken through the endplates and the core defines an I shape.5. The implant of claim 2 , wherein the elongate metallic element does not contact either of the upper and lower endplates.6. The implant of claim 2 , wherein the first and second ramped surfaces bear against each other.7. An expandable spinal fusion ...

DELIVERY SYSTEM FOR DEPLOYING A SELF-EXPANDING TUBE, AND METHOD OF DEPLOYING A SELF-EXPANDING TUBE

Delivery systems for deploying a self-expanding tube into a blood vessel are disclosed. In one arrangement, a tubular member is provided that is configured for insertion into the blood vessel. An elongate body extends within a lumen of the tubular member. A self-expanding tube is positioned radially between the tubular member and the elongate body. Over at least 50% of the length of the self-expanding tube, at least a portion of the self-expanding tube engages outwardly with the tubular member and inwardly with the elongate body. A longitudinal engagement force acting between the self-expanding tube and the tubular member and a longitudinal engagement force acting between the self-expanding tube and the elongate body are such that, during all stages of deployment of the self-expanding tube in use by longitudinal retraction of the tubular member relative to the elongate body, there is substantially no relative movement longitudinally between the elongate body and any portion of the self-expanding tube that remains in engagement with the elongate body. 1. A delivery system for deploying a self-expanding tube into a blood vessel , comprising:a tubular member configured for insertion into the blood vessel;an elongate body extending within a lumen of the tubular member; anda self-expanding tube positioned radially between the tubular member and the elongate body, wherein:over at least 50% of the length of the self-expanding tube, at least a portion of the self-expanding tube engages outwardly with the tubular member and inwardly with the elongate body; anda longitudinal engagement force acting between the self-expanding tube and the tubular member and a longitudinal engagement force acting between the self-expanding tube and the elongate body are such that, during all stages of deployment of the self-expanding tube in use by longitudinal advancement of the elongate body relative to the tubular member, there is substantially no relative movement longitudinally between the ...

Implantable graft and methods of making same

The present invention relates to an implantable endoluminal graft comprised of a microporous thin-film metal covering having a plurality of openings and a structural support element underlying and physically attached to the microporous thin-film metal covering, the microporous thin-film metal covering having shape memory properties.

SYSTEM, DEVICES AND METHODS FOR ANCHORING AND/OR SEALING A HEART VALVE PROSTHESIS

Methods, devices and systems for anchoring and/or sealing a heart valve prosthesis and, in particular, a mitral valve prosthesis (). Inflatable elements () are used to seal and anchor the mitral valve prosthesis () and/or other elements associated with repairing a native mitral valve. 193.-. (canceled)94. An inflatable anchor system for a mitral valve prosthesis , comprising:a continuous annular balloon capable of being delivered to the native mitral valve position of a heart of a patient; andan inflatable anchor formed in a generally annular or semi-annular shape, the inflatable anchor including a portion that is capable of being inflated at the location of a mitral valve annulus;wherein the inflatable anchor is configured for positioning below the native mitral valve annulus, on a ventricular side of native mitral valve leaflets of the native mitral valve, and the continuous annular balloon is configured for positioning on an atrial side of the native mitral valve leaflets, to assist in anchoring the mitral valve prosthesis by trapping the native mitral valve leaflets between the continuous annular balloon and the inflatable anchor, andwherein the inflatable anchor comprises discrete inflatable elements for locating between a left ventricular wall and chordae tendinae.95. The system of claim 94 , further comprising a wire operatively coupled to the inflatable anchor and configured to guide the inflatable anchor under at least a portion of the native mitral valve.96. The system of claim 94 , wherein the discrete inflatable elements include discrete and separately inflatable balloons.97. The system of claim 94 , wherein the discrete inflatable elements include first and second inflatable leaflet capturing members configured to be inflated to capture and stabilize the native mitral valve leaflets.98. The system of claim 94 , further comprising a plurality of anchoring arms configured to engage the inflatable anchor and/or at least one of the native mitral valve ...

Apparatuses and methods for at least partially supporting a valve leaflet of a regurgitant heart valve

An apparatus for partially supporting a leaflet of a regurgitant heart valve includes at least one subvalvular device including a subvalvular supporting portion and an anchor portion. The subvalvular supporting portion and anchor portion are each at least partially formed from at least one of braided mesh strands of a first configuration, braided mesh strands of a second configuration, a balloon, a plurality of longitudinally extending struts, and a plurality of laterally extending struts. A connector neck is interposed longitudinally between, and is attached to both of, the subvalvular supporting portion and the anchor portion. The connector neck penetrates longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site.

STENT AND METHOD OF MAKING SAME

A stent for vascular interventions having a hybrid open cell geometry. Variants of the stent include bare metal stents and drug-eluting stents. Embodiments of the stent include end projections for radiopaque markers or a discontinuous partial radiopaque coating on low-stress or low-strain regions of the peripheral stent. The stents of the invention are characterized by having thin walls, nested rows of struts, high expansion ratio, high and uniform radial force over entire diametric size and length of device, crush resistance up to and including about 90% of its fully expanded diameter, high fatigue resistance and high corrosion resistance. 1. A method of making a stent , comprising the steps of:a. Providing a stent hypotube;b. Patterning the stent hypotube with a stent pattern;c. Forming a plurality of volume-enhancing features in or on an outer abluminal surface of the stent pattern;d. Releasing the stent pattern from the stent hypotube; ande. Coating the outer abluminal surface of the stent pattern with a drug-release coating and at least substantially filling the plurality of volume-enhancing features.2. The method of claim 1 , wherein the step of providing a stent hypotube further comprises the step of making the stent hypotube from a binary claim 1 , ternary or quaternary shape memory or superelastic material.3. The method of claim 2 , wherein the step of making a stent hypotube further comprises the step of alloying a radiopaque material with shape memory or superelastic material.4. The method of claim 1 , further comprising the step of coating at least a portion of the released stent pattern with a radiopaque material prior to conducting step e.5. The method of claim 1 , further comprising the step of coating low-stress regions of the released stent with a radiopaque material.6. The method of claim 1 , wherein the step of patterning the stent hypotube further comprises the steps of:a. Forming a plurality of generally sinusoidal circumferential ring members ...

RADIOPAQUE MARKER ASSEMBLY

A radiopaque marker having a frame and a radiopaque cuff joined to the frame. The frame includes first and second end frame members and lateral frame members. The radiopaque cuff is joined to the frame such that the radiopaque cuff is substantially co-planar with the first and second end frame members. The radiopaque marker may be joined to a stent, such as for vascular interventions. Variants of the stent include bare metal stents and drug-eluting stents. Embodiments of the stent include end projections for radiopaque markers or a discontinuous partial radiopaque coating on low-stress or low-strain regions of the peripheral stent. The stents are characterized by having thin walls, nested rows of struts, high expansion ratio, high and uniform radial force over entire diametric size and length of device, crush resistance up to and including about 90% of its fully expanded diameter, high fatigue resistance and high corrosion resistance. 1. A radiopaque marker comprising , a frame member having a recessed portion and a radiopaque cuff coupled to the frame member and the recessed portion.2. The radiopaque marker of claim 1 , wherein the radiopaque cuff has a surface that is substantially co-planar with the frame member.3. The radiopaque marker of claim 1 , wherein the frame member further comprises a substantially quadrilateral frame having a central open region.4. The radiopaque marker of claim 3 , wherein the recessed portion further comprises at least one surface of the substantially quadrilateral frame.5. The radiopaque marker of claim 3 , wherein the radiopaque cuff has a portion thereof recessed within the central open region.6. The radiopaque marker of wherein the substantially quadrilateral frame further comprises a first end frame member and a second end frame member claim 3 , each of the first end frame member and the second end frame member having a longitudinal axis substantially orthogonal to a longitudinal axis of the substantially quadrilateral frame.7. ...

VENOUS VALVE PROSTHESES

In some examples an implantable medical device may include a frame and a flexible tubular valve body. The frame may define a frame lumen and may be expandable from a compressed configuration to an expanded configuration. The flexible tubular valve body may extend between a downstream end and an upstream end. The valve body may define a valve lumen, a downstream opening at the downstream end, and an upstream opening at the upstream end. The valve body may be attached to the frame such that the frame lumen is in fluid communication with the valve lumen. The valve body may comprise a neck and may be configured to fold about the neck to at least partially close the valve lumen. The valve body may be configured to collapse in an absence of fluid flow through the valve lumen to at least partially close the valve lumen. 1: An implantable medical device comprising:a frame defining a frame lumen, the frame being expandable from a compressed configuration to an expanded configuration; anda flexible tubular valve body extending between a downstream end and an upstream end, the valve body defining a valve lumen, a downstream opening at the downstream end, and an upstream opening at the upstream end, wherein the valve body is attached to the frame such that the frame lumen is in fluid communication with the valve lumen, the valve body comprising a neck and being configured to fold about the neck to at least partially close the valve lumen in an absence of fluid flow through the valve lumen or in the presence of retrograde fluid flow, and the valve body configured to unfold about the neck to open in the presence of antegrade fluid flow through the valve lumen.2: The implantable medical device of claim 1 , wherein the downstream opening is smaller than the upstream opening.3: The implantable medical device of claim 1 , wherein the downstream opening is circular.4: The implantable medical device of claim 1 , wherein the downstream opening is oval.5: The implantable medical device ...

WOVEN OR BRAIDED TUBULAR METAL CONSTRUCT

Multi-filament microcables are used in place of the traditional monofilament wires as the constituent elements of a woven or braided band. This enhances the function and manufacturability of such bands for various applications, such as orthopaedic applications including sternotomy closures. 1. A multifilament tubular construct , comprising: 'a plurality of metal filaments having respective longitudinal axes running substantially parallel to one another.', 'a plurality of constituent elements woven or braided into a tubular construct defining an inner diameter, an outer diameter and an axial length in the absence of external forces, the constituent elements each comprising2. The multifilament tubular construct of claim 1 , wherein the constituent elements are twisted cables in which the longitudinal axes of the plurality of metal filaments each define helices running substantially parallel to one another.3. The multifilament tubular construct of claim 1 , wherein the plurality of metal filaments of the constituent elements comprises between 2 filaments and 343 filaments.4. The multifilament tubular construct of claim 1 , wherein the inner diameter of the tubular construct is between 0.010 inches and 0.200 inches.5. The multifilament tubular construct of claim 4 , wherein the outer diameter of the tubular construct is between 0.014 inches and 0.208 inches.6. The multifilament tubular construct of claim 1 , wherein the plurality of constituent elements comprises between 8 and 128 constituent elements.7. The multifilament tubular construct of claim 1 , wherein the plurality of constituent elements define a plurality of picks at respective points of intersection between neighboring constituent elements claim 1 , the picks numbering between 1 and 50 per inch of axial distance along an outer surface of the tubular construct.8. The multifilament tubular construct of claim 1 , further comprising at least one friction-fit fitting formed on an end of the tubular construct.9. ...

HEART VALVE SEALING DEVICES AND DELIVERY DEVICES THEREFOR

An exemplary valve repair device for repairing a native valve of a patient includes a pair of paddles, a coaption element, and a covering. The coaption element has a first end portion and a second end portion. The coaption element is connected to the pair of paddles. The covering is disposed over the caption element. The covering prevents blood from flowing through the caption element. 1. A valve repair device for repairing a native valve of a patient , the valve repair device comprising:a pair of paddles;a coaption element having a first end portion and a second end portion connected to the pair of paddles;a covering over the caption element, wherein the covering prevents blood from flowing through the caption element.2. The valve repair device of wherein the covering extends from the first end portion to the second end portion.3. The valve repair device of wherein the covering extends from a middle portion of the caption element to the first end portion.4. The valve repair device of wherein the covering extends from a middle portion of the caption element to the second end portion.5. The valve repair device of further comprising a sealed collar connected to the first end portion of the caption element.6. The valve repair device of wherein the sealed collar is configured to accept a delivery shaft and to form a seal that prevents blood from entering the caption element when the delivery shaft is removed from the collar.7. The valve repair device of wherein the coaption element is hollow.8. The valve repair device of wherein the coaption element is made from a flexible mesh material and the covering is disposed over the mesh material.9. The valve repair device of wherein the covering material is made from a cloth.10. The valve repair device of further comprising a sealed collar connected to the second end portion of the caption element.11. The valve repair device of further comprising additional coverings over the each of the paddles.12. A valve repair device for ...

Heart valve sealing devices and delivery devices therefor

In an exemplary method of implanting a valve repair device on a mitral valve of a patient, first and second clasps of the valve repair device are closed to grasp the leaflets of the mitral valve. First and second paddles of the valve repair device are closed to bring the leaflets of the mitral valve into contact with a coaption element.

SYNTHETIC RESIN STENT

Provided is a synthetic resin stent with which it is possible to improve the resistance to pressure applied radially from the outside in a state of expanded diameter even when the fibers are thinned. A synthetic resin stent provided with a stent main body part and a diameter expansion mechanism that connects to the stent main body part and changes the stent main body part from a state of contracted diameter to a state of expanded diameter together with holding the stent main body part in a state of expanded diameter, wherein the diameter expansion mechanism is provided with a ring-shaped member attached to the distal end side of the stent main body part a string-shaped member one end of which is connected to the proximal end side of the stent main body part and inserted through the ring-shaped member and the other end side of which extends to the proximal end side of the stent main body part and a locking part disposed in the vicinity of the connecting portion of the string-shaped member and the stent main body part the locking part being capable of locking the ring-shaped member 1. A synthetic resin stent comprising: a stent main body part formed in a cylindrical shape by fibers made of synthetic resin and being deformable from a state of contracted diameter to a state of expanded diameter; anda diameter expansion mechanism that is connected to the stent main body part, deforms the stent main body part from a state of contracted diameter to a state of expanded diameter and holds the stent main body part in the state of expanded diameter,wherein the diameter expansion mechanism comprises:a ring-shaped member attached to a distal end side of the stent main body part;a string-shaped member, one end portion of which is connected to a proximal end side of the stent main body part and inserted through the ring-shaped member, and an other end side of which extends to the proximal end side of the stent main body part; anda locking part disposed at a connecting portion of ...

ENDOLUMINAL DEVICE

The present invention relates to an endoluminal device for implantation in a body lumen, such as a pancreatic duct. The device is provided with a distal end region having greater flexibility than that of a medial region of the device. 1. An endoluminal device comprising:a stent having a proximal terminal end and a distal terminal end and a longitudinal axis extending therebetween, the stent formed from a plurality of wires;wherein a distal end region adjacent the distal terminal end includes a plurality of loops formed by the plurality of wires, each loop being formed by an end region of a first wire of the plurality of wires connected to an end region of a second wire of the plurality of wires at a joining region, each joining region including only two wires, each loop having only one joining region, each loop having straight side portions, wherein the joining region is proximal of the distal terminal end and distal of the straight side portions.2. The endoluminal device of claim 1 , wherein the first wire extends to the distal terminal end of the stent and is bent back toward the proximal terminal end to form a distal tip of the loop that defines the distal terminal end of the stent.3. The endoluminal device of claim 1 , wherein there is no contact between adjacent straight side portions of adjacent loops.4. The endoluminal device of claim 1 , wherein each of the plurality of loops in the distal end region circumferentially overlaps two adjacent loops of the plurality of loops in the distal end region.5. The endoluminal device of claim 1 , wherein at least one of the first and second wires forming each of the loops in the distal end region crosses over and/or under two other loops of the plurality of loops in the distal end region.6. The endoluminal device of claim 1 , wherein each of the plurality of loops in the distal end region is interbraided with two adjacent loops of the plurality of loops in the distal end region.7. The endoluminal device of claim 1 , ...

Medical Device With Enhanced Shape Characteristics

A medical device is disclosed and may have a spiral shape structure that can function as a stent, such as a flow diversion stent to treat aneurysms. The medical device may have a spiral shape structure that can function as an occlusive device, for instance to occlude aneurysms. The medical device may include a shape setting structure to selectively adjust the shape of the medical device. 120-. (canceled)21. An implant for treating an aneurysm comprising:a scaffold structure;said scaffold structure having a compressed state, a resting state, and a final pre-set state;a state-setting mechanism suited for changing said scaffold from said resting state to said final pre-set state.22. The implant of claim 21 , wherein said state-setting mechanism is heat activated.23. The implant of claim 21 , wherein said implant is composed of a mesh of at least one wire.24. The implant of claim 23 , wherein said state-setting mechanism is inter-braided in said mesh.25. The implant of claim 22 , wherein said state-setting mechanism comprises a heating element having two contacts claim 22 , each oppositely polarized.26. The implant of claim 25 , wherein a first end of said heating element is connected to said first contact and a second end of said heating element is connected to said second contact.27. The implant of claim 26 , said heating element comprising a first coil at said first end of said state-setting mechanism and a second coil at said second end of said state-setting mechanism; each of said first and second coils linked claim 26 , respectively claim 26 , with said first and second contacts.28. The implant of claim 21 , wherein said state-setting mechanism is comprised of at least one wire.29. The implant of claim 21 , wherein said final pre-set state is a spiral shape.30. The implant of claim 21 , wherein said implant is a stent.31. The implant of claim 21 , wherein said implant is an occlusive device.32. A medical implant comprising:a tubular structure;said tubular ...

STENTS, SYSTEMS, AND METHODS FOR GASTROINTESTINAL TRACT TREATMENT

The present disclosure relates generally to stents, systems, and methods for gastrointestinal treatment. In some embodiments, a stent may include a tubular scaffold having a first end opposite a second end, wherein a lumen extends between the first and second ends. The tubular scaffold may include a flared section and a medial section extending from the flared section, wherein a first diameter of the flared section is greater than a second diameter of the medial section. The stent may further include a liner extending partially along a surface of the tubular scaffold, wherein the liner is spaced from an anchoring region of the flared section to promote tissue ingrowth with the flared section. 1. A stent , comprising: a flared section;', 'a medial section extending from the flared section, wherein a diameter of the flared section is greater than a diameter of the medial section; and, 'a tubular scaffold having a first end opposite a second end, wherein a lumen extends between the first and second ends, the tubular scaffold comprisinga liner extending partially along a surface of the tubular scaffold, wherein the liner is spaced from an anchoring region of the flared section to promote tissue ingrowth with the flared section.2. The stent of claim 1 , wherein the liner is spaced apart from a medial anchoring region of the medial section to promote tissue ingrowth with the medial section.3. The stent of claim 2 , wherein the medial anchoring region is provided at an expanded portion of the medial section claim 2 , and wherein the expanded portion has a third diameter greater than the diameter of the medial section.4. The stent of claim 3 , wherein the liner is spaced from the expanded portion to promote tissue ingrowth with the expanded portion.5. The stent of claim 1 , wherein the anchoring region is located along a sloped portion of the flared section claim 1 , and wherein the sloped portion extends away from a central longitudinal axis extending through the lumen.6. ...

METHOD OF TREATING A DEFECTIVE HEART VALVE

A method of treating a defective heart valve includes inserting a delivery catheter through a small incision in a patient's groin, wherein the delivery catheter has a prosthetic device positioned along a distal end. The prosthetic device includes an insert member and an anchoring member. The insert member is positioned between the native heart valve and is allowed to self-expand. The anchoring member is preferably a stent connected to the insert member by at least one elongate member. The stent is deployed within an adjacent blood vessel for anchoring the insert member between the native leaflets. After deployment of the prosthetic device, the native leaflets of the heart valve form a tight seal against the insert member for preventing regurgitation through the native heart valve during ventricular systole. 1. A method of reducing regurgitation in a native heart valve , the method comprising:inserting a delivery catheter through a small incision and into a patient's vasculature, the delivery catheter having a prosthetic device contained within a sheath along a distal end portion of the delivery catheter, the prosthetic device including a self-expanding insert member and an anchoring member, wherein at least one elongate connecting member couples the self-expanding insert member to the anchoring member, wherein the self-expanding insert member is shaped for filling a gap between native leaflets of a heart valve;advancing the distal end of the delivery catheter through a patient's vasculature and toward the heart valve;allowing the self-expanding insert member to self-expand in the gap between the native leaflets of the heart valve; andallowing the anchoring member to self-expand into engagement with an inner wall of a blood vessel, wherein the anchoring member takes the form of a stent having an open frame construction, the stent formed by a plurality of circumferential bands, each band including zig-zag struts shaped for engaging the inner wall of the blood vessel ...

TRANSCATHETER BIO-PROSTHESIS MEMBER AND SUPPORT STRUCTURE

An implantable valve replacement system for a cardiovascular valve may include an adjustable stabilizing ring. The stabilizing ring may be composed of a body member that is transitionable from an elongate insertion geometry to an annular operable geometry. The stabilizing ring may further include a plurality of anchors deployable in the annular operable geometry to engage the annulus of the cardiovascular valve. The ring may be used in conjunction with an implantable valve frame. The valve frame may be located within the ring and the ring, in turn, may be stabilized through the anchors engaging the valve annulus. The valve replacement system may be applied by engaging the ring in its annular operable geometry with the valve annulus through the anchors. The valve frame may be inserted through the opening of the ring, thereby forming a stabilizing mechanical contact between the frame and the annulus. 1. An implantable valve system comprising: a body member that is transitionable from an elongate insertion geometry to an annular operable geometry, and', 'a plurality of anchors deployable in the annular operable geometry to engage the annulus of the cardiovascular valve; and, 'an adjustable stabilizing ring comprisingan implantable valve frame in mechanical communication with the adjustable stabilizing ring,wherein the elongate insertion geometry is configured to allow percutaneous passage of the stabilizing ring, via a catheter, to a position adjacent to an annulus of a cardiovascular valve, andwherein the annular operable geometry has a closed state to conform to the annulus of the cardiovascular valve.2. The implantable valve system of claim 1 , wherein the implantable valve frame comprises one claim 1 , two claim 1 , three or four valve leaflets.3. The implantable valve system of claim 1 , wherein the adjustable stabilizing ring claim 1 , the implantable valve frame claim 1 , or both are coated with a pliable material.4. The implantable valve system of claim 1 , ...

INDEPENDENT PROXIMAL ELEMENT ACTUATION METHODS

Fixation system for fixation of leaflets of a heart valve including an implantable fixation device having a first arm and a second arm, a first proximal element moveable relative to the first arm between a first position and a second position, and a second proximal element moveable relative to the second arm between a first position and a second position. The fixation system includes a delivery device having a catheter, a first proximal element line and a second proximal element line, and a handle having a first and second proximal element line handles coupled to the first proximal element line and the second proximal element line, respectively. The handle can include an interlock moveable between an unlocked position and a locked position. 1. A fixation system for fixation of leaflets of a heart valve comprising: a first arm and a second arm,', 'a first proximal element moveable relative to the first arm between a first position and a second position, and', 'a second proximal element moveable relative to the second arm between a first position and a second position; and, 'an implantable fixation device comprising'} a catheter having a proximal end portion and a distal end portion, the catheter defining at least one lumen extending between the proximal end portion and the distal end portion,', 'a first proximal element line extending through the at least one lumen, the first proximal element line releasably coupled to the first proximal element and actuatable to move the first proximal element between the first position and the second position,', 'a second proximal element line extending through the at least one lumen, the second proximal element line releasably coupled to the second proximal element and actuatable to move the second proximal element between the first position and the second position, and', a first proximal element line handle coupled to and actuatable to deploy the first proximal element line to move the first proximal element between the first ...

SYSTEMS AND METHODS FOR TREATING LUMINAL VALVES

A partial valve prosthesis includes a framework configured for following a shape of a portion of the native valve annulus when implanted into the native valve annulus, the framework including securement features for anchoring the framework to an inner periphery of the native valve annulus and retaining at least one leaflet configured to replace a corresponding one of the plurality of native leaflets; and at least one leaflet secured to the framework. Additional embodiments and methods are disclosed. 1. A partial valve prosthesis to replace a portion of a native luminal valve , the native luminal valve defining a native valve annulus and a plurality of native leaflets , the partial valve prosthesis comprising:a framework configured to follow a shape of a portion of the native valve annulus when implanted into the native valve annulus, the framework including an array of clamps attached thereto, each of the clamps including an elongate flattened imperforate metallic body and having a first end to clamp above the native valve annulus and a second end to clamp below the native valve annulus, the clamps being arranged about a portion of the native valve annulus to anchor the prosthesis to an inner periphery of the native valve annulus, the framework being further configured to retain at least one valve leaflet configured to replace a corresponding one of the plurality of native leaflets; andat least one leaflet secured to the framework.2. The partial valve prosthesis as in claim 1 , wherein at least one of the clamps includes at least one of a perforation and a loop at the respective first end or second end of said at least one of the clamps a terminal end.3. The partial valve prosthesis as in claim 1 , wherein at least one of the clamps defines a perforation therethrough at the first or second end of the clamp claim 1 , and further wherein a fastener is directed through said perforation that passes through tissue of said native valve annulus.4. The partial valve ...

Bone structural device

A bone structural device including a plurality of bone structural segments, wherein adjacent bone structural segments are pivotally connected to one another about a pivot axis, and the bone structural segments are expandable in height, which is in a direction generally parallel to the pivot axis.

Patient Specific Adjustment of Cochlear Implant Insertion Trajectories

An electrode guide device is described for inserting a cochlear implant electrode array into a scala tympany of a patient cochlea has an electrode guide tube and an end positioner at least partially contained within a cavity of the guide tube at the distal end and slidable within the cavity for adjustable extension beyond the distal end. The end positioner has a natural curvature that is constrained by the cavity of the guide tube for any portion contained within the cavity of the guide tube, and any portion of the end positioner extended beyond the distal end follows the natural curvature. The electrode array can be introduced through the groove of the guide tube along a first directional line towards an electrode opening in the patient cochlea, and then the distal end of electrode array emerging from the guide tube is redirected by the extension of the end positioner along a different second directional line through the electrode opening. 1. An intrasurgical electrode guide device for inserting a cochlear implant electrode array into a scala tympany of a patient cochlea , the device comprising:an electrode guide tube having a cavity, a proximal end and a distal end connected by a partially enclosed groove having a slot opening along one side to allow loading and/or unloading of a cochlear implant electrode array into the guide tube so that the electrode array can slide within the groove to project a distal end of the electrode array beyond the distal end of the guide tube; andan end positioner at least partially contained within the cavity of the guide tube at the distal end and slidable within the cavity for adjustable extension beyond the distal end,wherein the end positioner is characterized by a natural curvature that is constrained by the guide tube for any portion of the end positioner contained within the cavity of the guide tube,wherein any portion of the end positioner extended beyond the distal end follows the natural curvature, andwherein the guide tube ...

IMPLANTABLE CARDIAC VALVE IMPROVEMENT DEVICE, SYSTEM AND PROCEDURE

An implantable medical device is disclosed including an anchor unit configured to be permanently anchored at a cardiac valve of a patient, at least one locking unit, such as for fixation of tissue of the cardiac valve and/or fixation of at least a part of a shape of the anchor unit, and at least one coupling unit for connecting the anchor unit to at least one of the locking unit. The coupling unit has a first end portion and a second end portion, wherein the first end portion is connectable to the anchor unit, and the second end portion includes the locking unit. 1. An implantable medical device including:an anchor unit configured to be permanently anchored at a cardiac valve of a patient,at least one locking unit, andat least one coupling unit of fixed or adjustable length for connecting said anchor unit to at least one of said locking unit;said coupling unit having a first end portion and a second end portion, said first end portion connectable to said anchor unit, and said second end portion including said locking unit.2. The device of claim 1 , wherein said anchor unit is a flexible anchor unit and said at least one coupling unit stabilizes said anchor unit when said coupling unit is connected to said anchor unit and locked by said locking unit.3. The device of claim 2 , wherein said coupling unit includes at least one lockable arm.4. The device of claim 1 , wherein said coupling unit includes at least one arm connectable at a first end to said anchor unit and connectable remote of said first end to at least one leaflet of said valve for fixation of tissue of said cardiac valve.5. The device of claim 1 , wherein a driving unit claim 1 , is connectable to said at least one coupling unit.6. The medical device of claim 5 , wherein said locking unit includes an attachment element for releasably connecting said driving unit to said anchor unit.7. The medical device of claim 5 , wherein said coupling unit comprises at least one freely pivoting and/or rotating joint.8. ...

CHAIN ANNULOPLASTY RING, DELIVERY SYSTEM AND RELATED METHODS

An at least partial annuloplasty ring for transcatheter cardiac valve treatment is disclosed. The annuloplasty ring has a plurality of separate chain segments serially interlinked and articulated to a chain. The chain has a substantially elongate delivery configuration and a curved deployment configuration. At least one of said chain segments has at least one tissue anchor attached to it, wherein the tissue anchor is movably arranged at least partly within the chain segment in the delivery configuration and protrudes from the chain segment in the deployment configuration in order to anchor with cardiac tissue. 1. An at least partial annuloplasty ring for transcatheter cardiac valve treatment , comprising a plurality of separate chain segments serially interlinked and articulated to a chain , said chain having a substantially elongate delivery configuration and a curved deployment configuration , at least one of said chain segments including at least one attached tissue anchor , said tissue anchor being movably arranged at least partly within said chain segment in said delivery configuration and arranged to protrude from said chain segment in said deployment configuration to anchor with cardiac tissue.2. The annuloplasty ring of claim 1 , wherein said tissue anchor being connected to said chain segment claim 1 , and including a helical spiral or threaded tissue anchor.3. The annuloplasty ring of claim 1 , wherein said tissue anchor being lockable in a longitudinally compressed state in said chain segment.4. The annuloplasty ring of having a ring shape with a flexible curvature in an unlocked state by said chain segments being articulated to each other by joints segments and said ring being rigid in transverse direction to the curvature by said each of said joints being rotatable in one plane only respectively.5. The annuloplasty ring of claim 1 , wherein said chain has a chain length that is adjustable by at least two adjacent chain segments being arranged to ...