Devices and methods for treating defects in the tissue of a living being

An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery.

Joint arthroplasty devices and surgical tools

Disclosed herein are methods, compositions and tools for repairing articular surfaces repair materials and for repairing an articular surface. The articular surface repairs are customizable or highly selectable by patient and geared toward providing optimal fit and function. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty.

Bilayered bone graft device

A bilayered bone graft device includes a core portion comprising deminernalized gelatin and a shell portion surrounding the core portion. The shell portion includes a calcium silicate and the deminernalized gelatin in a range of 1 to 30 weight percent, and the calcium silicate has a molar ratio of calcium to silicon ranging from 10 to 0.1. The core portion and the shell portion are bound by the deminernalized gelatin without using a binder. In one embodiment of the present invention, the core portion is configured to provide buffering for receiving an insertion, and the shell portion is configured to provide a load-bearing structure.

Joint arthroplasty devices and surgical tools

Disclosed herein are methods, compositions and tools for repairing articular surfaces repair materials and for repairing an articular surface. The articular surface repairs are customizable or highly selectable by patient and geared toward providing optimal fit and function. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty.

Methods and Compositions for Articular Repair

Disclosed herein are methods and compositions for producing articular repair materials and for repairing an articular surface. In particular, methods for providing articular repair systems. Also provided are articular surface repair systems designed to replace a selected area cartilage, for example, and surgical tools for repairing articular surfaces.

Stent Coating Apparatus with Fibers

A stent coating apparatus for coating a stent includes a brush assembly, a stent support, and a dispensing mechanism. The brush assembly includes a plurality of fibers, and the stent support carries a stent at a position in which the stent is in contact with the fibers. The dispensing mechanism dispenses a coating composition to the plurality of fibers.

Methods of securing a fastener

Embodiments may include an attachable fastener, which may include a bondable material that may be secured to the end of an end effector. Vibration may be tuned to occur at a distal end of the fastener. Accordingly, the fastener may be used to generate heat at a distal point of contact. If the contact surface contains bondable material, that material may be softened. If the fastener includes bondable material at the point of contact, that material may also be softened by heat produced by vibration at the contact area. A hard implant or another polymeric material may function as the anvil.

Method and Devices for Intracorporeal Bonding of Implants with Thermal Energy

A system for dynamically controlling a weld profile includes a generator, and end effector, a sensor, and a computer. The generator is configured to supply energy based on the weld profile. The end effector operatively connected to the generator and configured to apply vibratory energy and pressure to an object. The sensor configured to provide an output with respect to the object. The computer configured to monitor the output and change the weld profile of the generator based on the output.

SYSTEMS AND METHODS FOR INCONTINENCE CONTROL

A system for managing female incontinence includes a body of biocompatible material configured to fit between the labia minora and the vestibule floor, the body having a surface configured to occlude the urethral meatus, an adhesive carried on at least a first portion of the surface and configured to provide a sealing engagement between the body and the urethral meatus, and a substance carried by at least one of the body and the adhesive and configured for controlling the odor of the general vaginal-urethral area of a female. 1a body of biocompatible material configured to fit between the labia minora and the vestibule floor, the body having a surface configured to occlude the urethral meatus;an adhesive carried on at least a first portion of the surface and configured to provide a sealing engagement between the body and the urethral meatus; anda substance carried by at least one of the body and the adhesive and configured for controlling the odor of the general vaginal-urethral area of a female.. A system for managing female incontinence comprising: This application is a continuation of U.S. patent application Ser. No. 15/206,157, filed on Jul. 8, 2016, which is a continuation of U.S. patent application Ser. No. 14/870,104, filed on Sep. 30, 2015, which claims the benefit of priority to U.S. Provisional App. No. 62/059,833, filed on Oct. 3, 2014, all of which are incorporated by reference in their entirety herein for all purposes. Priority is claimed pursuant to 35 U.S.C. §120 and 35 U.S.C. §119.The field of the invention generally relates to devices for treating urinary incontinence.Urinary incontinence is a troublesome problem for many individuals. Urinary stress incontinence is a particular form of urinary incontinence wherein a physical occurrence may cause unwanted leakage of urine. For example, a sudden spike in abdominal pressure from sneezing, coughing or exercise may exceed the resistive pressure of the urethra for a brief moment, causing an involuntary ...

FILMS AND METHODS OF MANUFACTURE

Embodiments of the present disclosure are directed to perforated polymer films and methods of making the same. In some embodiments, the films are for use with implantable medical devices. In one embodiment there is a flexible body including a polymer film having a first surface and an opposing second surface, the film having a plurality of apertures extending from the first surface to the second surface and a plurality of raised lips protruding from the first surface such that each of the plurality of apertures is surrounded by a one of the plurality of raised lips. In one embodiment, the film comprises a single layer, and in another embodiment, the film can comprise a plurality of layers. In certain embodiments, the film can comprise an adhesive layer. In another embodiment, one or more of the layers may be a drug containing layer and/or a rate controlling layer for drug release. 1. A method of forming a multi-layer film for drug delivery comprising:placing a first polymer solution into a mold having a plurality of protrusions extending from a bottom of the mold;urging the first polymer solution around each of the plurality of protrusions;placing one or more additional polymer solutions into the mold; and,solidifying the first polymer solution and the one or more additional polymer solutions;wherein a multi-layer film having a plurality of apertures is formed; and,wherein at least one of the first polymer solution or the one or more additional polymer solutions comprises a drug.2. The method of claim 1 , wherein the step of placing one or more additional polymer solutions into the mold occurs prior to the step of urging claim 1 , such that urging the polymer solution includes urging the first polymer solution and the one or more polymer solutions.3. The method of claim 1 , wherein the step of solidifying the polymer solution occurs both prior to and after the step of placing one or more additional polymer solutions into the mold.4. The method of claim 1 , wherein ...

ARTIFICIAL JOINT CUP, MAGNETIC CONTROL SPUTTERING COATING FILM DEVICE AND PREPARATION METHOD THEREOF

The present invention aims at improving and upgrading the conventional devices based on the low temperature magnetron sputtering coating devices. Starting from the material systems, the invention provides a new material system and a manufacturing method thereof based on a high molecular weight polyethylene joint cup to solve the poor binding force problem between the film and the matrix, and the problems of easy oxidization and carbonization of high molecular weight polyethylene with low temperature magnetron sputtering technologies at the same time. On the above basis, the ultra-lubrication performance of graphite-like structure films and ultra-hardness of diamond-like structure films are utilized to construct a nano-scale multilayer structure DLC film alternatively coated with a graphite-like film and a diamond-like film. The present invention improves the wear resistance of high molecular weight polyethylene joint cups, and restricts low accuracy of joints due to creeping by constructing a new artificial hip joint cup of ultra-wear-resisting nano-scale multilayer structure DLC film with high hardness and self-lubricating capability. 1. An artificial joint cup , comprising:a matrix and a nano-scale multilayer film coated on the matrix, the nano-scale multilayer film comprising:a pure Ti bottom layer crosslinked with the matrix,a Ti-TiC transition layer on the pure Ti bottom layer, anda composite layer on the Ti-TiC transition layer and a pure carbon film layer on the composite layer;wherein the composite layer is a nano-scale multilayer structure including a monolayer graphite-like film and a monolayer diamond-like film deposited alternately, andwherein, in the direction from the bottom layer to the composite layer, the mass percentage of Ti in the Ti-TiC transition layer gradually decreases, and the mass percentage of C therein gradually increases.2. The artificial joint cup according to claim 1 , wherein the matrix is a high molecular weight polyethylene joint ...

GORE-TEX COVERED BREAST IMPLANTS TO MINIMIZE CAPSULAR REACTION AND INFECTION WHILE REDUCING PALPABILITY

This invention relates generally to a breast implant having an ePTFE layer, a Silicone layer of a breast implant core, and an interface between the ePTFE layer and the Silicone layer. 1. An improved breast implant , comprising:an ePTFE layer;a Silicone layer of a breast implant core; andan interface between the ePTFE layer and the Silicone layer.2. The breast implant of claim 1 , wherein the interface is a mechanical interface.3. The breast implant of claim 2 , wherein the mechanical interface further comprises a plurality of mechanical coupling elements.4. The breast implant of claim 3 , wherein the mechanical coupling elements have a tetrapod shape.5. The breast implant of claim 1 , wherein the interface is an adhesive interface. This application is a continuation of U.S. patent application Ser. No. 14/876,754, filed Oct. 6, 2015, which claims priority to and the benefit of U.S. Provisional Application No. 62/066,704, entitled “EPTFE IMPLANTS”, filed Oct. 21, 2014, and which claims priority to and the benefit of U.S. Provisional Application No. 62/060,480, entitled “CORTEX COVERED BREAST IMPLANTS TO MINIMIZE CAPSULAR REACTION”, filed Oct. 6, 2014, which applications are hereby incorporated in their entirety by reference.Implant can be used to augment particular areas of the human body, such as calves, breasts and others. Implantation of implants can be used for reconstructive purposes or cosmetic purposes. For breast implants, reconstructive implantation purposes can include implantation after mastectomy for breast cancer, where a woman has had one or both breasts removed, while cosmetic reasons for implantation can include to change the size, firmness, or shape of the breast or for other aesthetic reasons.Current breast implants include saline implants and silicone implants. Saline implants can include silicone shells filled with sterile salt water such as saline. Silicone implants can include silicone shells filled with silicone gel. Implantation procedures ...

METHOD FOR USE OF A DOUBLE-STRUCTURED TISSUE IMPLANT FOR TREATMENT OF TISSUE DEFECTS

A method for use of a double-structured tissue implant or a secondary scaffold stand-alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand-alone secondary scaffold implant or unit for treatment of tissue defects. 1. A method for treating a tissue defect comprising:a. preparing a double-structured tissue implant comprising a three-dimensional primary scaffold;b. preparing said tissue defect for implantation;c. precutting said double-structured tissue implant;d. coating said defect with a tissue adhesive;e. implanting said double-structured tissue implant into said defect, wherein said implant is rehydrated with a physiologically acceptable solution or buffer before or after implantation; andf. covering said implant with a tissue adhesive;wherein said three-dimensional primary scaffold comprises a plurality of pores,wherein said plurality of pores comprises a secondary scaffold comprising lyophilized and dehydrothermally treated collagen and a surfactant, andwherein said secondary scaffold forms a fibrous and cross-linked collagen network within said plurality of pores.2. The method of claim 1 , wherein said primary scaffold defines a top surface and a bottom surface of said implant.3. The method of claim 1 , wherein the collagen has been lyophilized at a temperature of about −10° C. to about −210° C. over a period of about 2 to about 60 minutes and dehydrothermally treated at a temperature of about 70° C. to about 200° C. for about 30 minutes to about 7 days.4. The method of claim 1 , wherein the pores have a diameter of about 300±100 μm.5. The method of claim 4 , wherein the sizes and diameters of the pores on both the top surface and the bottom surface are substantially the same.6. The implant of claim 5 , wherein the ...

Composite joint arthroplasty systems and methods

A prosthesis may have an articulating component formed via casting and a 3D printed bone anchoring component with a joint-facing side and a bone-facing side. The bone-facing side may have a bone engagement surface with a porous structure with pores selected to facilitate in-growth of the bone into the pores. The bone facing side may further have a surface layer of Titanium Dioxide nanotubes. The joint-facing side may be secured to the articulating component by melting Titanium nanoparticles at a temperature below the melting temperatures of the major constituents of the articulating component and/or the bone anchoring component, such as Cobalt, Chromium, and/or Titanium, so as to avoid significantly modifying the crystalline structures of the articulating component and/or the bone anchoring component. The melting temperature of the Titanium nanoparticles may be about 500° C.

METHODS OF IMPLANTING A DRY BIOPROSTHETIC VALVED CONDUIT

A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection. 1. A method of preparing and delivering a valved conduit , comprising:removing a pre-assembled valved conduit from a dry package in which the valved conduit is stored without a preserving solution, the valved conduit including a bioprosthetic heart valve coupled to a conduit, the heart valve having leaflets of bioprosthetic tissue and the conduit being sealed with a bioresorbable medium; anddelivering and securing the valved conduit to an implantation site.2. The method of claim 1 , wherein the conduit is secured to the bioprosthetic valve using sutures.3. The method of claim 2 , wherein the heart valve has a suture-permeable sewing ring surrounding an inflow end thereof claim 2 , wherein an inlet end of the conduit is secured to the sewing ring with sutures.4. The method of claim 3 , wherein the heart valve has commissure posts between which the leaflets are supported and a sewing ring claim 3 , and the heart valve couples to the conduit with the commissure posts inside the conduit and the sewing ring outside the conduit.5. The method of claim 1 , ...

Antithrombotic artificial blood vessel

An artificial blood vessel is a tubular fabric including a fiber layer containing an ultrafine fiber(s) and an ultrafine fiber layer in the inside of the fiber layer, the ultrafine fiber layer being composed of an ultrafine fiber(s) having a fiber diameter(s) of not less than 10 nm and not more than 3 μm, wherein a quaternary ammonium group-containing polymer having alkyl groups each of a carbon number 10 or less is covalently bound to the ultrafine fiber(s); heparin is ionically bound to the quaternary ammonium group-containing polymer; and the residual heparin activity after washing with physiological saline at 37° C. for 30 minutes is 20 mIU/cm2 or more.

METHODS OF PREPARING AND DELIVERING A DRY BIOPROSTHETIC VALVED CONDUIT

A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection. 1. A method of preparing and delivering a valved conduit , comprising:procuring a pre-assembled valved conduit including a prosthetic heart valve having bioprosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve, the valve being coupled to a conduit sealed with a bioresorbable medium so as to provide the valved conduit and stored in a dry package including at least one sterile container in which the valved conduit is stored without a preserving solution;opening the dry package and removing the valved conduit; anddelivering the valved conduit to an implantation site.2. The method of claim 1 , wherein the conduit is secured to the bioprosthetic valve using sutures.3. The method of claim 1 , wherein the bioprosthetic valve couples within the conduit such that the conduit extends on both ends of the valve to provide both inflow and outflow extensions.4. The method of claim 1 , wherein the bioprosthetic valve is a heart valve and includes bovine pericardial ...

IMPLANTABLE DEVICE, ESPECIALLY FOR THE RECONSTRUCTION OF THE ABDOMINAL WALL

The present invention relates to an implantable device, in particular for wall repair comprising a reinforcing textile implant having first and second surfaces, a bioadhesive coating to coat said first surface at least in part, said coating comprising at least one ionic, cross-linked bioadhesive polymer selected from among the following polymers: an acrylic acid polymer, methacrylic acid polymer, itaconic acid polymer, maleic acid polymer or maleic anhydride polymer having an adhesive function that can be activated in an aqueous medium. 111-. (canceled)12. An implantable device , comprising:a reinforcing textile implant having first and second surfaces;a bioadhesive coating coating at least in part said first surface, said bioadhesive coating comprising at least one ionic, cross-linked bioadhesive polymer selected from among the following polymers: an acrylic acid polymer, a methacrylic acid polymer, an itaconic acid polymer, a maleic acid polymer and a maleic anhydride polymer, the ionic, cross-linked bioadhesive polymer having an adhesive function that can be activated in an aqueous medium.13. The implantable device according to claim 12 , wherein the polymer is cross-linked by a cross-linking agent selected from among a sugar polyalkenyl polyether claim 12 , a polyalcohol polyalkenyl polyether and a divinyl glycol.14. The implantable device according to claim 13 , wherein the cross-linking agent is selected from among a sucrose allyl ether and an allyl claim 13 , diallyl claim 13 , triallyl or tetraallyl pentaerythritol.15. The implantable device according to claim 12 , wherein the bioadhesive polymer is a carbomer.16. The implantable device according to claim 12 , wherein the bioadhesive coating is obtained after the polymerisation of a composition comprising at least one monomer selected from among: acrylic acid claim 12 , methacrylic acid claim 12 , itaconic acid claim 12 , maleic acid anhydride claim 12 , and a maleic anhydride claim 12 , and a cross-linking ...

HERNIA PATCH

A hernia patch supporting tissue in-growth conforms to a tissue wall upon surgical installation and fixation within a patient. The hernia patch can include a base and positioning straps. The base is formed of two layers that are affixed to each other around the perimeter of the patch, for example by stitching. A stabilizing washer is provided between the two layers, and the stitch is provided peripherally around the stabilizing washer, keeping the washer free-floating between the layers. The base, positioning straps, and stabilizing washer are formed of a structure that does not separate the layers of the implant or form a space in the form of a pocket, and promotes more uniform and confluent tissue incorporation or in-growth after implantation. The hernia patch may further include a hydrolysable bioabsorbable cross-linked coating of a fatty acid based material, such as an omega-3 fatty acid based material. 121-. (canceled)22. A patch for treating a hernia , comprising:a base comprising two layers and a tissue conformable stabilizing washer disposed within a continuous interior compartment between the two layers, the continuous interior compartment extending continuously from an outer periphery of the stabilizing washer to a center of the base, wherein the two layers are affixed to each other only at a location between the outer periphery of the stabilizing washer and an outer periphery of the base in such a way as to form the continuous interior compartment with the stabilizing washer free floating therein; anda positioning strap attached to the base in such a way that when a pull force is applied thereto, the base is pulled by the positioning strap toward a tissue location, and the base is configured to conform against the tissue location.23. The patch of claim 22 , wherein the base configured to conform against the tissue location comprises a surface that is configured to face the tissue location and bend and flex to follow contours of the tissue in such a way ...

ASSEMBLED IMPLANT

This invention is directed to an assembled implant comprising two or more portions of bone that are held together in appropriate juxtaposition with one or more biocompatible pins to form a graft unit. Preferably, the pins are cortical bone pins. Typically, the cortical pins are press-fitted into appropriately sized holes in the bone portions to achieve an interference fit. The bone portions are allograft or xenograft. 1. A method for manufacture of autograft , allograft and xenograft implants which comprises assembling such implants from smaller pieces of graft materials to form a larger graft implant product.261-. (canceled) This application is a continuation of U.S. application Ser. No. 12/690,074, filed Jan. 19, 2010, now issued as U.S. Pat. No. 9,763,787, which is a continuation of U.S. application Ser. No. 09/782,594, filed Feb. 12, 2001, now abandoned.This invention relates to implants and methods for their preparation wherein components of the implant are assembled from constituent pieces to produce a complete implant.In the field of medicine, there has been an increasing need to develop implant materials for correction of biological defects. Particularly in the field of orthopedic medicine, there has been the need to replace or correct bone, ligament and tendon defects or injuries. As a result, there have emerged a number of synthetic implant materials, including but not limited to metallic implant materials and devices, devices composed in whole or in part from polymeric substances, as well as allograft, autograft, and xenograft implants. It is generally recognized that for implant materials to be acceptable, they must be pathogen free, and must be biologically acceptable. Generally, it is preferable if the implant materials may be remodeled over time such that autogenous bone replaces the implant materials. This goal is best achieved by utilizing autograft bone from a first site for implantation into a second site. However, use of autograft materials is ...

PRE-ASSEMBLED PACKAGED BIOPROSTHETIC VALVE CONDUIT

A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection. 1. A pre-assembled , packaged valved conduit , comprising:a bioprosthetic valve including bioprosthetic tissue, the valve having been treated such that the bioprosthetic tissue has less than 70% water content and may be stored dry for extended periods without degradation of functionality of the valve;a conduit sealed with a bioresorbable medium to which the bioprosthetic valve is coupled so as to provide the valved conduit; anddry packaging for the valved conduit including at least one sterile container in which the valved conduit is stored without a preserving solution.2. The valved conduit of claim 1 , wherein the conduit is secured to the bioprosthetic valve using sutures.3. The valved conduit of claim 1 , wherein the bioprosthetic valve is a heart valve and includes bovine pericardial leaflets claim 1 , and the conduit comprises a tubular matrix impregnated with collagen.4. The valved conduit of claim 1 , wherein the tissue has been cross-linked using glutaraldehyde or other aldehyde containing agents claim 1 , treated with a capping agent claim ...

Method of drying bioabsorbable coating over stents

Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.

COATED MEDICAL DEVICES AND METHODS OF MAKING AND USING SAME

Coating methods and related devices are provided. Such devices can include stents. For example, the device can comprise a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm. The device can also comprise an anti-thrombogenic coating distributed over at least a portion of the device such that the pores are substantially free of webs formed by the coating. 1. A medical device for treating an aneurysm , comprising:a tubular member comprising a plurality of braided filaments that form a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm; andan anti-thrombogenic material distributed over the tubular member such that the pores are substantially free of webs formed by the material;wherein the tubular member exhibits an elapsed time before peak thrombin formation that is at least 1.5 times the elapsed time of an identical, uncoated tubular member.2. The medical device of claim 1 , wherein the pores have an average pore size that is less than or equal to about 500 microns.3. The medical device of claim 1 , wherein the pores have an average pore size that is less than or equal to about 320 microns.4. The medical device of claim 3 , wherein the pores have an average pore size that is measured using an inscribed circle diameter.5. The medical device of claim 1 , wherein the distribution of the anti-thrombogenic material is substantially complete over the tubular member.6. The medical device of claim 5 , wherein the anti-thrombogenic material is generally uniform over the tubular member.7. The medical device of any ...

HEART VALVES WITH INCREASED EFFECTIVE ORIFICE AREA

A prosthetic heart valve for implant in a human. The valve includes a wireform with undulating inflow cusps and outflow commissure posts to which flexible leaflets attach and coapt in a flow area. Each leaflet may drape over the top of the wireform in the cusp area, but have tabs that each extend underneath the wireform at the commissure posts to be secured along with a tab of an adjacent leaflet. The prosthetic heart valve may also be a dual-wire wireform, with the leaflets sandwiched therebetween. One wireform may be larger than the other, with the leaflets extending over the smaller wireform. The smaller wireform may have commissures that bend radially outward from the larger wireform to provide structure to which the leaflet tabs attach. 1. A prosthetic heart valve , comprising:a first cloth-covered undulating wireform having alternating cusps and commissures around a periphery;a second cloth-covered undulating wireform having alternating cusps and commissures around a periphery, the cusps and commissures of the two wireforms being aligned with one another; anda plurality of flexible leaflets having outer edges sandwiched between the cusps of the first and second cloth-covered undulating wireforms.2. The heart valve of claim 1 , wherein a cloth tab on one of the wireforms encompasses a small piece of silicone ribbon at least at the cusps thereof to provide a sewing ring.3. The heart valve of claim 1 , wherein the flexible leaflets have commissure edges sandwiched between the commissures of the first and second cloth-covered undulating wireforms.4. The heart valve of claim 1 , wherein the first and second wireforms have similar sizes and shapes claim 1 , with the cusps curving in an inflow direction and the commissures defining upstanding commissure posts with inverted U-shapes projecting in an outflow direction.5. The heart valve of claim 4 , wherein the first wireform is slightly smaller in radius and shorter in axial dimension than the second wireform which is ...

SYSTEMS AND METHODS FOR INCONTINENCE CONTROL

A system for managing female incontinence includes a body of biocompatible material configured to fit between the labia minora and the vestibule floor, the body having a surface configured to occlude the urethral meatus, an adhesive carried on at least a first portion of the surface and configured to provide a sealing engagement between the body and the urethral meatus, and a substance carried by at least one of the body and the adhesive and configured for controlling the odor of the general vaginal-urethral area of a female. 15-. (canceled)726-. (canceled)27. A system for managing female incontinence comprising:a body of biocompatible material configured to fit between the labia minora and the vestibule floor, the body having a surface configured to occlude the urethral meatus;an adhesive carried on at least a first portion of the surface and configured to provide a sealing engagement between the body and the urethral meatus;a substance carried by at least one of the body and the adhesive and configured for controlling the odor of the general vaginal-urethral area of a female;a manipulation member coupled to at least one of the body and the adhesive and configured to be engaged by at least one finger, wherein the manipulation member comprises a tether coupled to at least one of the body and the adhesive, and wherein the tether comprises a first end and a second end, the first end of the tether incorporated into the at least one of the body and the adhesive and the second end of the tether configured for grasping, such that a tensile force can be placed on at least a portion of the body to aid its removal from between the labia minora and the vestibule floor; anda woven fabric incorporated into at least one of the body and the adhesive, wherein the first end of the tether is at least partially combined into the woven fabric.2830-. (canceled) This application claims the benefit of priority to U.S. Provisional Application No. 62/059,833, filed on Oct. 3, 2014, which ...

GORE-TEX COVERED BREAST IMPLANTS TO MINIMIZE CAPSULAR REACTION AND INFECTION WHILE REDUCING PALPABILITY

This invention relates generally to a breast implant having an ePTFE layer, a Silicone layer of a breast implant core, and an interface between the ePTFE layer and the Silicone layer. 1. An improved breast implant , comprising:an ePTFE layer;a Silicone layer of a breast implant core; andan interface between the ePTFE layer and the Silicone layer.2. The breast implant of claim 1 , wherein the interface is a mechanical interface.3. The breast implant of claim 2 , wherein the mechanical interface further comprises a plurality of mechanical coupling elements.4. The breast implant of claim 3 , wherein the mechanical coupling elements have a tetrapod shape.5. The breast implant of claim 1 , wherein the interface is an adhesive interface. This application claims priority to U.S. Provisional Application No. 62/060,480, entitled “GORETEX COVERED BREAST IMPLANTS TO MINIMIZE CAPSULAR REACTION”, filed Oct. 6, 2014, and U.S. Provisional Application No. 62/066,704, entitled “EPTFE IMPLANTS”, filed Oct. 21, 2014, which applications are hereby incorporated in their entirety by reference.Implants can be used to augment particular areas of the human body, such as calves, breasts and others. Implantation of implants can be used for reconstructive purposes or cosmetic purposes. For breast implants, reconstructive implantation purposes can include implantation after mastectomy for breast cancer, where a woman has had one or both breasts removed, while cosmetic reasons for implantation can include to change the size, firmness, or shape of the breast or for other aesthetic reasons.Current breast implants include saline implants and silicone implants. Saline implants can include silicone shells filled with sterile salt water such as saline. Silicone implants can include silicone shells filled with silicone gel. Implantation procedures typically involve a surgeon making an incision under the breast, under the arm or around the nipple and then implanting the implant into a pocket or capsule ...

IMPLANTS COMPRISING ANCHORING ELEMENTS

Implants that have anchoring elements, which are vertebral implants that can be used as intervertebral disk replacement in the form of cages for the fusion of vertebral bodies. 117.-. (canceled)18. A vertebral implant , comprising:an upper side;a lower side; anda shell surface, wherein the shell surface is subdivided into front, rear and side surfaces; andwherein the implant has anchoring elements for connection to end plates of adjacent vertebral bodies.19. The vertebral implant according to claim 18 , wherein the implant comprises a ceramic.20. The vertebral implant according to claim 19 , wherein the ceramic is an oxide ceramic material.21. The vertebral implant of claim 18 , wherein the ceramic is selected from the group consisting of an aluminum oxide and a zirconium oxide.22. The vertebral implant according to claim 18 , wherein the vertebral implant further comprises a bioactive coating.23. The vertebral implant according to claim 22 , wherein the bioactive coating comprises at least one member selected from the group consisting of hydroxyapatite claim 22 , tricalcium phosphate and a bioglass.24. The vertebral implant according to claim 18 , wherein the implant has a central cavity that extends at least through the upper and/or lower side so that bone regeneration of the adjacent vertebral bodies can take place through the implant.25. The vertebral implant according to claim 18 , wherein the shell surface has at least one opening through which the implant can be screwed to at least one adjacent vertebral body.26. The vertebral implant according to claim 25 , wherein the screws are composed of a ceramic-comprising material claim 25 , in particular a zirconium-oxide-comprising material.27. The vertebral implant according to claim 18 , wherein at least one of the upper side and the lower side is convexly curved in a longitudinal or a transverse direction.28. The vertebral implant according to claim 18 , wherein the upper and lower sides are arranged plane- ...

Methods and Devices for Utilizing Bondable Materials

The invention primarily relates to fastening and stabilizing tissues, implants, and/or bondable materials, such as the fastening of a tissue and/or implant to a bondable material, the fastening of an implant to tissue, and/or the fastening of an implant to another implant. This may involve using an energy source to bond and/or mechanically to stabilize a tissue, an implant, a bondable material, and/or other biocompatible material. The invention may also relate to the use of an energy source to remove and/or install an implant and/or bondable material or to facilitate solidification and/or polymerization of bondable material.

METAL OXIDE AND POLYMER-CONTROLLED DELIVERY SYSTEMS, SUNSCREENS, TREATMENTS, AND TOPICAL COATING APPLICATORS FOR ANTIFUNGAL AND ANTIMICROBIAL AGENTS

A dose applicator for preparing a mixture at a point of use includes a housing defining an interior and an opening. First and second ampoules are contained in the interior, wherein the first ampoule contains a first component and the second ampoule contains a second component comprising one or more antifungal agent. An applicator tip is secured in the opening so that when the first and second ampoules are broken, the first and second components mix to form the mixture and the mixture can egress from the application tip. 1. An applicator for preparing a mixture at a point of use comprising:a housing defining an interior and an opening;first and second containers contained in the interior, wherein the first container contains a first component and the second container contains a second component; andan applicator tip secured in the opening so that when the first and second components are mixed to form the mixture and the mixture can egress from the application tip; andthe component in the first container contains precursors which form a metal oxide and polymer hybridized matrix for controlled delivery of one or more antifungal agent; andthe component in the second container contains the one or more antifungal and/or antimicrobial agent.2. The applicator as recited in claim 1 , wherein the chemistry in the first container forms a matrix of at least one metal oxide consisting of titanium oxide or zirconium oxide or niobium oxide or tantalum oxide or a mixture of these oxides.3. The applicator as recited in claim 1 , wherein the chemistry in the second container contains at least one metal claim 1 , metal oxide claim 1 , metal salt or metal ester of silver claim 1 , vanadium claim 1 , zinc or copper or a mixture of these metals or oxides.4. The applicator as recited in claim 1 , wherein the metal or metal oxide from the second container becomes trapped within the matrix formed by the chemistry in the first container.5. The applicator as recited in claim 1 , where in the ...

Surgical Technique for alveolar ridge augmentation with maxillary sinus elevation (lateral approach) using a pre-portioned and ready pre-packaged graft composition in gelatin bag and method of producing it

The present embodiment relates generally to methods of performing surgical technique maxillary sinus floor augmentation with a lateral approach using a pre-portioned and ready pre-packaged bone graft composition in gelatin bags and method of producing gelatin bags. In addition the present inventions can be widely used in other medical fields such as dentistry, orthopedic surgery, spine surgery, plastic and reconstruction surgery, sport medicine, trauma surgery, phinoplasty surgery and veterinary. 1. A surgical technique for alveolar ridge augmentation with maxillary sinus elevation (lateral approach) using a pre-portioned and ready pre-packaged bone graft composition in gelatin bag , comprising:a first step of performing a trapezoid incision into soft tissue of gingiva in surgical area to create a trapezoid shaped flap;a second step of retracting back the trapezoid shaped flap of the soft tissue to expose an underlying lateral boney wall of the maxillary sinus;a third step of creating an access to the maxillary sinus, to get access to expose sinus membrane and detaching the sinus membrane from a bone of an inferior surface of a sinus cavitya fourth step applying pre-portioned and ready pre-packaged bone graft composition in gelatin bags into newly created space;a fifth step inserting dental implant through vertical opening;a sixth step suturing the trapezoid shaped flap into the soft tissue;2. The surgical technique of claim 1 , wherein the pre-portioned and ready pre-packaged bone graft composition in the gelatin bag contains bone graft material.3. The surgical technique of wherein-the pre-portioned and ready pre-packaged bone graft composition in the gelatin bag comprises coherent mass bone graft chips harvested from cortical bone.4. The surgical technique of wherein the pre-portioned and ready pre-packaged bone graft composition in the gelatin bag comprises coherent mass bone graft chips harvested from cancellous bone.5. The surgical technique of wherein the pre- ...

SURFACE TREATMENTS FOR ACCOMMODATING INTRAOCULAR LENSES AND ASSOCIATED METHODS AND DEVICES

An accommodating intraocular lens (AIOL) for implantation within a capsular bag of a patient's eye comprises first and second components coupled together to define an inner fluid chamber and an outer fluid chamber. The inner region of the AIOL provides optical power with one or more of the shaped fluid within the inner fluid chamber or the shape of the first or second components. A surface treatment or coating may be applied to one or more surfaces of the first and second components. The surface treatment is expected to decrease the roughness of the machined surfaces of the boundary surfaces of the first and second components, and thereby reduce the mass of water coalescing at such boundary surfaces. The disclosed surface treatments are also expected to increase the hydrophobicity (i.e., decrease the surface energy) of the corresponding surface(s), thereby decreasing the “wettability” of these surfaces. 1. An accommodating intraocular lens system , comprising:an accommodating structure including a first component, a second component posterior of the first optical component, an inner fluid chamber between the first and second optical components, and an outer fluid chamber fluidically coupled to the inner fluid chamber,wherein the first component and the second component are hydrophilic structures, and wherein one or more surfaces of the accommodating structure include a surface treatment to decrease a roughness of the corresponding treated region.2. The accommodating intraocular lens system of wherein the treated surfaces comprise the same proportion of hydrophobic and hydrophilic elements as the base material.3. The accommodating intraocular lens system of wherein the treated surfaces comprise a proportion of approximately 25% 2-Hydroxyethyl methacrylate (HEMA) elements to approximately 75% hydrophobic elements.4. The accommodating intraocular lens system of wherein an inner surface defining claim 1 , at least in part claim 1 , the inner fluid chamber includes the ...

COMPOSITE ePTFE AND SILICONE SOFT TISSUE IMPLANTS TO MINIMIZE CAPSULAR CONTRACTURE, WEIGHT, INFECTION AND PALPABILITY

Methods, systems, apparatuses and devices for implantation in a soft-tissue biological environment that include a primary layer for containing a filler substance, an interface and a secondary layer, including embodiments where the secondary layer an ePTFE layer, the primary layer is a silicone layer, the interface is mechanical or adhesive and the tiller substance can include particulates and lattices. 1. An implant apparatus for implantation in a soft-tissue biological environment , comprising:at least one wall including a primary layer for containing at least one tiller substance;an interface; anda secondary layer coupled to the primary layer via the interface,2. The implant apparatus of claim 1 , wherein the primary layer further comprises silicone and the secondary layer further comprises ePTFE.3. The implant apparatus of claim 2 , wherein the implant apparatus is a breast implant.4. The implant apparatus of claim 2 , wherein the interface is a mechanical interface.5. The implant apparatus of claim 4 , wherein the mechanical interface further comprises a plurality of mechanical coupling elements.6. The implant apparatus of claim 5 , wherein the mechanical coupling elements have a tetrapod shape.7. The implant apparatus of claim 2 , wherein the interface is an adhesive interface.8. The implant apparatus of claim 2 , further comprising: a silicone gel; and', 'particulates of a secondary material mixed in the silicone gel., 'the at least one filler substance, comprising9. The implant apparatus of claim 8 , wherein the particulates are ePTFE particulates.10. The implant apparatus of claim 1 , further comprising:a lattice structure within the primary layer.11. The implant apparatus of claim 2 , further comprising:a lattice structure within the primary layer, comprised of at least one ePTFE string.12. The implant apparatus of claim 11 , wherein the lattice structure is coupled to the primary layer claim 11 , the secondary layer or both.13. The implant apparatus of ...

Gore-tex covered breast implants to minimize capsular reaction and infection while reducing palpability

This invention relates generally to a breast implant having an ePTFE layer, a Silicone layer of a breast implant core, and an interface between the ePTFE layer and the Silicone layer.

GORE-TEX COVERED BREAST IMPLANTS TO MINIMIZE CAPSULAR REACTION AND INFECTION WHILE REDUCING PALPABILITY

This invention relates generally to a breast implant having an ePTFE layer, a Silicone layer of a breast implant core, and an interface between the ePTFE layer and the Silicone layer. 1. An improved breast implant , comprising:an ePTFE layer;a Silicone layer of a breast implant core; andan interface between the ePTFE layer and the Silicone layer.2. The breast implant of claim 1 , wherein the interface is a mechanical interface.3. The breast implant of claim 2 , wherein the mechanical interface further comprises a plurality of mechanical coupling elements.4. The breast implant of claim 3 , wherein the mechanical coupling elements have a tetrapod shape.5. The breast implant of claim 1 , wherein the interface is an adhesive interface. This application is a continuation of U.S. patent application Ser. No. 15/873,563, filed Jan. 17, 2018, which is a continuation of U.S. patent application Ser. No. 14/876,754, filed Oct. 6, 2015, now U.S. Pat. No. 9,901,439, which claims priority pursuant to U.S.C. § 119(e) to U.S. Provisional Application No. 62/066,704, entitled “EPTFE IMPLANTS”, filed Oct. 21, 2014, and to U.S. Provisional Application No. 62/060,480, entitled “GORTEX COVERED BREAST IMPLANTS TO MINIMIZE CAPSULAR REACTION”, filed Oct. 6, 2014, the disclosures of which are hereby incorporated by reference in their entireties.Implants can be used to augment particular areas of the human body, such as calves, breasts and others. Implantation of implants can be used for reconstructive purposes or cosmetic purposes. For breast implants, reconstructive implantation purposes can include implantation after mastectomy for breast cancer, where a woman has had one or both breasts removed, while cosmetic reasons for implantation can include to change the size, firmness, or shape of the breast or for other aesthetic reasons.Current breast implants include saline implants and silicone implants. Saline implants can include silicone shells filled with sterile salt water such as saline. ...

Implantable Device With Adhesive Properties

Implantable devices such as stents, coils, implantable contraceptives, vascular plugs, vena cava filters, left atrial appendage (LAA) closure devices employing an adhesive component to assist in securing or holding the implant in place within a lumen of a patient's body.

THERAPEUTICS DISPENSING DEVICE AND METHODS OF MAKING SAME

A therapeutics delivery system, and methods of making and using same, are disclosed for environments that rapidly clear any injected therapeutics, such as a patient's eye. The therapeutics delivery system releases the drug in a therapeutically effective concentration for a desired duration of time with a predefined drug kinetics. In one embodiment, the embodiments of the present disclosure release a therapeutically effective concentration for a longer time period than other delivery systems, for instance from a day to a week. Certain embodiments comprise a therapeutics dispensing device comprising a biodissolvable hydrogel matrix for long term drug release that allows the device to be placed directly at the injured site, e.g., onto the surface at or near the injury, and retained there rather than through injection, whether locally or systematically. 1. A device for delivering therapeutics to the eye comprising:a hydrogel matrix comprising at least one biocompatible material; anda plurality of reservoirs disposed in the hydrogel matrix;wherein at least a portion of a surface of the hydrogel matrix containing an open end of the plurality of reservoirs is configured to contact a surface of a user's eye and dissolves upon contact with the surface of the user's eye.2. The device of wherein the dissolution of the surface portion of hydrogel matrix occurs at a predetermined rate.3. The device of wherein the predetermined rate of dissolution is based at least on the biocompatible material.4. The device of wherein the at least one biocompatible material comprises at least one of the following: dextran claim 1 , polyvinyl alcohol claim 1 , carboxy methyl cellulose claim 1 , hydroxypropyl cellulose claim 1 , polyvinylpyrrolidone claim 1 , polyvinyl alcohol (PVA) claim 1 , Polylactide-co-glycolide (PLGA) claim 1 , polyhydroxy ethyl methacrylate (PolyHEMA) claim 1 , Polyhydroxy ethylacrylate claim 1 , gelatin materials claim 1 , collagen materials claim 1 , and any combination ...

METHOD OF DRYING BIOABSORBABLE COATING OVER STENTS

Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed. 19-. (canceled)10. A method of fabricating a stent , comprising:thermally treating a stent having a stent body including a composition applied to a surface of the stent body, the composition comprising a solvent and a first bioabsorbable polymer,wherein the stent body comprises a second bioabsorbable polymer,wherein a glass transition temperature (Tg) of the first bioabsorbable polymer is greater than human body temperature,wherein a process temperature of the thermal treatment is 15 to 20 deg C. above the Tg of the first bioabsorbable polymer,wherein a duration of the thermal treatment is 2 to 5 min; andcrimping the thermally treated stent onto a catheter so that it can be delivered to and deployed at a treatment site in a blood vessel.11. The method of claim 10 , wherein the second bioabsorbable polymer of the stent body comprises poly(L-lactide-co-caprolactone).12. The method of claim 10 , wherein the second bioabsorbable polymer of the stent body comprises poly(L-lactide).13. The method of claim 10 , wherein the first bioabsorbable polymer comprises poly(DL-lactide) (PDLA).14. The method of claim 10 , wherein the thermal treatment comprises blowing a heated gas on the stent.15. The method of claim 10 , wherein the stent is not baked after the thermal treatment.16. The method of claim 10 , wherein no additional thermal treatment of the stent is performed after the thermal treatment. This application is a continuation of U.S. application Ser. No. 14/155,217 filed ...

Fabric Material For Medical Devices

At least a portion of fabrics for use in medical devices is formed from polymeric materials. The fabrics may be uncoated, partially coated or fully coated with one or more layers of a polymer. The fabrics may be used for the leaflets and/or cuffs of prosthetic heart valves and as a component of other medical devices. 1. A prosthetic heart valve , comprising:an expandable stent extending in a longitudinal direction between an inflow end and an outflow end;a cuff coupled to a luminal surface of the stent; anda plurality of prosthetic leaflets coupled to at least one of the cuff and the stent and having an open condition and a closed condition, the plurality of prosthetic leaflets adapted to allow blood to flow from the inflow end toward the outflow end when in the open condition and to retard blood from flowing from the outflow end toward the inflow end when in the closed condition, each of the plurality of leaflets being formed of a fabric;wherein the fabric has a first group of fibers extending in a first direction of the fabric and a second group of fibers extending in a second direction of the fabric different than the first direction, the first group of fibers and the second group of fibers being interlaced in an ordered arrangement, the first group of fibers and the second group of fibers both being composed of ultra-high molecular weight polyethylene (UHMWPE), at least one layer of the fabric having a thread count of between about 300 and about 500 fibers by between about 100 and about 300 fibers per square inch, the fabric having a thickness of between about 50 μm and about 100 μm.2. The prosthetic heart valve of claim 1 , wherein the fabric is a woven fabric.3. The prosthetic heart of claim 2 , wherein each of the plurality of prosthetic leaflets includes a free edge adapted to move as the plurality of prosthetic leaflets transitions between the open condition and the closed condition claim 2 , and an attachment edge directly attached to at least one of the ...

COMPOSITE ePTFE AND SILICONE SOFT TISSUE IMPLANTS TO MINIMIZE CAPSULAR CONTRACTURE, WEIGHT, INFECTION AND PALPABILITY

Methods, systems, apparatuses and devices for implantation in a soft-tissue biological environment that include a primary layer for containing a filler substance, an interface and a secondary layer, including embodiments where the secondary layer an ePTFE layer, the primary layer is a silicone layer, the interface is mechanical or adhesive and the filler substance can include particulates and lattices. 1. An implant apparatus for implantation in a soft-tissue biological environment , comprising:at least one wall including a primary layer for containing at least one filler substance;an interface; anda secondary layer coupled to the primary layer via the interface.2. The implant apparatus of claim 1 , wherein the primary layer further comprises silicone and the secondary layer further comprises ePTFE.3. The implant apparatus of claim 2 , wherein the implant apparatus is a breast implant.4. The implant apparatus of claim 2 , wherein the interface is a mechanical interface.5. The implant apparatus of claim 4 , wherein the mechanical interface further comprises a plurality of mechanical coupling elements.6. The implant apparatus of claim 5 , wherein the mechanical coupling elements have a tetrapod shape.7. The implant apparatus of claim 2 , wherein the interface is an adhesive interface.8. The implant apparatus of claim 2 , further comprising: a silicone gel; and', 'particulates of a secondary material mixed in the silicone gel., 'the at least one filler substance, comprising9. The implant apparatus of claim 8 , wherein the particulates are ePTFE particulates.10. The implant apparatus of claim 1 , further comprising:a lattice structure within the primary layer.11. The implant apparatus of claim 2 , further comprising:a lattice structure within the primary layer, comprised of at least one ePTFE string.12. The implant apparatus of claim 11 , wherein the lattice structure is coupled to the primary layer claim 11 , the secondary layer or both.13. The implant apparatus of ...

Methods and Compositions for Articular Repair

Disclosed herein are methods and compositions for producing articular repair materials and for repairing an articular surface. In particular, methods for providing articular repair systems. Also provided are articular surface repair systems designed to replace a selected area cartilage, for example, and surgical tools for repairing articular surfaces.

Devices and methods for treating defects in the tissue of a living being

An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may include, or have blended in, an additive, such as an osteoinductive factor, for example biocompatible ceramics and glass.

Artificial femoral ball head with multi-layer shell core composite structure

An artificial femoral ball head having a multilayer shell-core composite structure includes a spherical shell layer, a transition layer and an inner core. The inner core is made of a toughened ceramic, the spherical shell layer is made of a ceramic material, and the transition layer is made of a composite material comprising materials of the inner core and the spherical shell layer. The artificial femoral ball head is manufactured through sintering a green body of successively stacked layers of the spherical shell layer, the transition layer and the inner core, and the green body of successively stacked layers is obtained through a powder co-injection molding process. The spherical shell layer of the artificial femoral head has a high rigidness, corrosion-proof and wear-proof performance. The inner core of the artificial femoral head has a high toughness and shockresistant performance.

IMPLANTABLE TISSUE REPAIR DEVICES AND METHODS FOR MANUFACTURING THE SAME

An implantable tissue repair device for the repair, replacement or augmentation of a tissue, the device having a biocompatible solvated structural material, where at least part of the structural material is in a compressed and/or dried state. 1. An implantable tissue repair device for the repair , replacement or augmentation of a tissue , the device comprising a biocompatible solvated structural material , wherein at least part of the structural material is in a compressed and/or dried state.2. A device as claimed in wherein the part or parts are both compressed and dried.3. A device as claimed in comprising a body and one or more anchoring elements projecting from the body.4. A device as claimed in wherein the anchoring elements or a part thereof are compressed and/or dried.5. A device as claimed in wherein both the body and the anchoring elements are compressed and/or dried.6. A device as claimed in wherein the anchoring elements are integrally formed with the structural material of the body.7. A device as claimed in wherein the structural material is a hydrogel.8. A device as claimed in wherein the part or parts of the device which are in a compressed and/or dried state have dimensions no more than 95% of the part's or parts' original uncompressed and/or solvated state.9. A device as claimed in wherein the structural material comprises a material selected from silk fibroin claim 1 , fibrin claim 1 , fibronectin claim 1 , cellulose claim 1 , alginate claim 1 , hyaluronic acid claim 1 , gelatin and collagen.10. A device as claimed in further comprising a network of fibres located at least partially within the structural material.11. A device as claimed in wherein the fibres in the fibre network are formed from a biocompatible fibre material selected from silk claim 10 , cellulose claim 10 , alginate claim 10 , gelatin claim 10 , fibrin claim 10 , fibronectin claim 10 , hyaluronic acid claim 10 , chondroitin sulphate claim 10 , ceramic claim 10 , metal and alloy.12. ...

APPARATUS, SYSTEM AND METHOD FOR PROVIDING A COATING FOR AN IMPLANATABLE LENS

An apparatus, system and method for coating an implantable lens. The apparatus, system and method may include at least one coating layer applied to at least one surface of the optic of the implantable lens, wherein the coating layer at least partially protects the optic at least during the implantation, and wherein the coating layer is removable following implantation. The coating layer may include a lubricant and/or medication and may be in the form of a biodegradable polymer and/or a film. 1. A system , comprising:an implantable lens having an optic;at least one coating layer applied to at least one surface of the optic, wherein said coating layer varies in thickness.2. The system of claim 1 , wherein said coating layer is capable of removal following the implantation.3. The system of claim 1 , further comprising at least one additional coating layer applied to a second surface of the optic claim 1 , wherein said additional coating layer is capable of at least partially protecting the second surface of the optic.4. The system of claim 1 , wherein the application to the at least one surface of the optic comprises at least one selected from the group consisting of an adhesion claim 1 , a contact force claim 1 , and an impregnation.5. The system of claim 1 , wherein said coating layer comprises multiple layers.6. The system of claim 2 , wherein the capability of removal comprises one selected from the group consisting of mechanical removability and chemical removability.7. The system of claim 2 , wherein the capability of removal comprises degradation over a predefined time period comprising one selected from the group consisting of a range of about a day to multiple years claim 2 , and an approximation of a healing time from the implantation.8. The system of claim 1 , wherein the lens further comprises a haptic comprising at least one haptic coating layer. This application is a continuation application and claims priority to U.S. application Ser. No. 14/161,469, ...

FRICTIONLESS HIP JOINT

An orthopedic prosthesis includes a head which internally accommodates the major motion of a patient, e.g., during walking, thereby reducing wear against a cup or liner. A neck may be utilized which rotates within the distal member about an axis aligned with the major motion of the patient. The orthopedic prosthesis may also include a sacrificial anode, a seal made of natural fibers, and utilize lubricant made of honey. 1. An orthopedic hip prosthesis comprising:a prosthetic femoral neck including a cylindrical axle extending from a proximal end thereof, said axle defining an outer circumferential surface;a prosthetic femoral head configured to be rotationally connected to said prosthetic femoral neck, said prosthetic femoral head comprising a cylindrical recess defining an inner circumferential surface; anda plurality of ball bearings positioned between said outer circumferential surface of said axle and said inner circumferential surface of said recess, said plurality of ball bearings disposed to restrict translational movement of said prosthetic femoral neck relative to said prosthetic femoral head, said plurality of ball bearings being retained inside an annular retention channel,wherein said prosthetic femoral head and said prosthetic femoral neck are configured to accommodate motion of a hip joint.2. An orthopedic hip prosthesis as recited in further comprising a plurality of roller bearings disposed between said outer circumferential surface of said axle and said inner circumferential surface of said recess claim 1 , said plurality of roller bearings disposed to support rotational movement between said prosthetic femoral head and said prosthetic femoral neck.3. An orthopedic hip prosthesis as recited in wherein said annular retention channel is disposed distally of said plurality of roller bearings on said neck.4. An orthopedic hip prosthesis as recited in further comprising a bearing passage claim 1 , said bearing passage in communication with said annular ...

TISSUE ENGINEERED DEVICES AND METHODS FOR MAKING SAME

Tissue engineered constructs and methods for fabricating the disclosed constructs are provided. Some of the disclosed tissue engineered constructs are designed to fill a void in the body due to surgical resection, for example from mastectomy or lumpectomy, wounds and the like. Some disclosed constructs comprise one or more projections designed to mimic the appearance of a structural feature when implanted into a host. 1. A volume forming unit (VFU) comprising adipocytes and at least one projection.2. The VFU of claim 1 , wherein the VFU further comprises endothelial channels.3. The VFU of claim 1 , wherein the at least one projection is designed to simulate at least one structural feature of a nipple.4. The VFU of claim 3 , wherein a second projection is designed to simulate the at least one structural feature of an areola and the second projection circumscribes the at least one projection designed to simulate at least one structural feature of a nipple.5. A method for creating a VFU claim 3 , comprising:adding (i) a mixture comprising at least one biocompatible hydrogel material and a multiplicity of cells to (ii) a negative mold;incubating the mold under conditions suitable for hydrogel formation, thereby creating the VFU.6. The method of claim 5 , wherein the cells comprise at least one of adipocytes claim 5 , endothelial cells claim 5 , fibroblasts claim 5 , or mesenchymal stem cells.7. The method of claim 5 , wherein the mixture comprising at least one biocompatible hydrogel material and a multiplicity of cells comprises at least two solutions that may be added to the mold simultaneously or in any order.8. The method of claim 5 , wherein at least one component of the mixture is added to the mold using bioprinting.95. The method of claim 5 , wherein the at least one biocompatible hydrogel material comprises at least one of fibrinogen claim 5 , a fibrinogen activator claim 5 , or thrombin.10. The method of claim 5 , wherein:(a) the cells comprise at least one of ...

COMPOSITE JOINT ARTHROPLASTY SYSTEMS AND METHODS

A prosthesis may have an articulating component formed via casting and a 3D printed bone anchoring component with a joint-facing side and a bone-facing side. The bone-facing side may have a bone engagement surface with a porous structure with pores selected to facilitate in-growth of the bone into the pores. The bone facing side may further have a surface layer of Titanium Dioxide nanotubes. The joint-facing side may be secured to the articulating component by melting Titanium nanoparticles at a temperature below the melting temperatures of the major constituents of the articulating component and/or the bone anchoring component, such as Cobalt, Chromium, and/or Titanium, so as to avoid significantly modifying the crystalline structures of the articulating component and/or the bone anchoring component. The melting temperature of the Titanium nanoparticles may be about 500° C. 1. A prosthesis for replacing an articular surface on bone , the prosthesis comprising: an articulating component joint-facing side comprising an articular surface; and', 'an articulating component bone-facing side comprising a bone-facing shape; and, 'an articulating component formed via casting, the articulating component comprising a bone anchoring component joint-facing side comprising a joint-facing shape that is complementary to the bone-facing shape, wherein the bone anchoring component joint-facing side is secured to the articulating component bone-facing side; and', 'a bone anchoring component bone-facing side comprising a bone engagement surface having a porous structure with pores selected to facilitate in-growth of the bone into the pores., 'a bone anchoring component having a 3D printed structure, the bone anchoring component comprising2. The prosthesis of claim 1 , wherein:the bone anchoring component is formed of DMLS Titanium; andthe 3D printed structure comprises a porous structure.3. The prosthesis of claim 2 , wherein the porous structure has a lower porosity on the bone ...

Stent

A stent able to minimize occurrences of strain and stress concentration in a drug coat layer upon expansive deformation of the stent in a radial direction to avoid the possibility of the drug separating from the stent, includes a stent body and a drug coating layer coated on the outside surface of the stent body so that the thickness of the drug coating layer gradually decreases toward a bent portion of the stent.

Bioabsorbable mesh for surgical implants

Described are methods, devices, and systems related to pelvic implants, including implants that include absorbable and non-absorbable materials.

Method for use of a double-structured tissue implant for treatment of tissue defects

A method for use of a double-structured tissue implant or a secondary scaffold stand-alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand-alone secondary scaffold implant or unit for treatment of tissue defects.

Bioabsorbable mesh for surgical implants

Described are methods, devices, and systems related to pelvic implants, including implants that include absorbable and non-absorbable materials.

PRE-ASSEMBLED BIOPROSTHETIC VALVE CONDUIT AND METHOD OF DELIVERY

A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection. 1. A pre-assembled valved conduit , comprising:a bioprosthetic valve including bioprosthetic tissue leaflets, the valve having been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve, the bioprosthetic valve having a sewing ring encircling an inflow end;a conduit sealed with a bioresorbable medium that is coupled to the sewing ring with sutures so as to form the valved conduit;a valve holder attached to the bioprosthetic valve on an outflow side thereof; andan elongated delivery handle connected to the valve holder and extending through the conduit so as to project from an outlet end thereof.2. The valved conduit of claim 1 , wherein the bioprosthetic valve is a heart valve located at an inlet end of the conduit that wraps around the sewing ring.3. The valved conduit of claim 2 , wherein the sutures coupling the conduit inlet end to the sewing ring pass through the entire sewing ring from inflow to outflow sides thereof.4. The valved conduit of claim 1 , wherein the bioprosthetic ...

Detection of luminal urinary catheter colonization

Technologies are generally described for indwelling medical devices for detection of luminal catheter colonization. A substrate for use as an indwelling medical device includes an elevated biofilm releasing medium including a dye for release into urine on the occurrence of an elevated biofilm build-up on the substrate in the urine; and an elevated pH releasing medium including a dye on the substrate different from the dye used to detect biofilm build-up for release into urine on the occurrence of an elevated pH level in the urine. Methods of manufacture and use of the disclosed indwelling medical devices are also described.

SYNTHETIC HEART VALVES COMPOSED OF ZWITTERIONIC POLYMERS

A prosthetic heart valve includes a plurality of synthetic polymeric leaflets. Each leaflet has a base polymer and a polymer coating at least partially disposed over the base polymer, wherein the polymer coating includes polymerized units of a monomer comprising a zwitterionic group when the polymer coating is exposed to an aqueous environment at a pH of about 7.4 1. A prosthetic heart valve comprising a plurality of synthetic polymeric leaflets , each leaflet having a base polymer and a polymer coating disposed over the base polymer , wherein the polymer coating is formed from a monomer comprising zwitterionic pendant groups.2. The prosthetic heart valve of claim 1 , wherein the anion of the zwitterionic group is formed by a carboxylic acid group claim 1 , a sulfonic acid group claim 1 , or a phosphoric acid group.3. The prosthetic heart valve of claim 1 , wherein the cation of the zwitterionic group is formed by an (cyclo)aliphatic or aromatic amine claim 1 , an amidine claim 1 , or a guanidine; or is a quaternary amine.4. The prosthetic heart valve of claim 1 , wherein polymer coating consists essentially of polymerized units of monomers each comprising a zwitterionic group.5. The prosthetic heart valve of claim 1 , wherein the cation is a quaternary amine.6. The prosthetic heart valve of claim 1 , wherein the cation and the anion of the zwitterionic group are part of the same pendant group of the monomer unit.7. The prosthetic heart valve of claim 1 , wherein the pendant group has the structure X—(CH2)n-N+R2-(CH2)m-Y or X—(CH2)n-O—P(O—)—(CH2)m-Z claim 1 , wherein:X is the point of covalent attachment to the repeat unit of the monomer;each R is independently selected from C1- to C4-alkyl, in particular methyl;n and m are each integers between 1 and 8, in particular between 2 and 3;Y is a anionic group selected from COO—, SO3-, O—SO3-, O—PO3-, and PO3-; andZ is a cationic group derived from a (cyclo)aliphatic or aromatic amine, an amidine, a guanidine, or a ...

Implant for Repairing a Cartilage Defect

An implant for repairing a cartilage defect comprising a first layer and a second layer. The first layer comprises a membrane-like structure and the second layer comprises a sponge-like structure with directional and/or interconnected pores. The first layer is facing the synovial space and the second layer is located towards bone. 1. An implant for repairing a cartilage defect comprising: a first layer comprising a stable scaffolding in the form of a membrane structure; and a second layer comprising at least one wettable material and a sponge structure comprising interconnected pores; wherein 1) the pores form hollow fiber structures orientated directionally in columns and that run substantially parallel to each other , have a substantially consistent pore size and 2) said first layer faces an opposite direction relative to said second layer and 3) wherein said first layer comprises a material having a resorption time exceeding a resorption time of said second layer.2. The implant according to claim 1 , wherein that said first layer and said second layer each comprises biocompatible materials.3. (canceled)4. The implant according to claim 1 , wherein said first layer comprises a material which is selected from the group consisting of collagen claim 1 , bioresorbable polymers claim 1 , pericardium claim 1 , composites and glycosaminoglycans claim 1 , or mixtures of two or more of these materials.5. The implant according to claim 1 , wherein said second layer comprises a physiological component of bone selected from the group consisting of calcium phosphates claim 1 , calcium sulfates claim 1 , calcium fluorides claim 1 , calcium oxides claim 1 , hydroxyl apatites claim 1 , or mixtures of two or more of these components.6. The implant according to claim 1 , wherein said at least one wettable material comprises a material which is selected from the group consisting of collagen claim 1 , hyaluronic acid claim 1 , alginate claim 1 , chitosan claim 1 , gelatine claim 1 , ...

Spinal implants with stem cells

A spinal implant device has a synthetic or metallic or a combination thereof of these materials in an implant body structure and stem cells in a coating, or a sheet, wrap or a membrane wrap applied to surfaces on the implant body structure or alternatively filled with a plug of stem cell laden material. The implant body structure preferably has an aperture or channel. The spinal implant device may include anchoring holes to secure the device to the spinal skeletal structure with fasteners or alternatively can simply be held in place by and between adjacent vertebrae.

Fabric Material For Medical Devices

At least a portion of fabrics for use in medical devices is formed from polymeric materials. The fabrics may be uncoated, partially coated or fully coated with one or more layers of a polymer. The fabrics may be used for the leaflets and/or cuffs of prosthetic heart valves and as a component of other medical devices. 1. A replacement heart valve comprising:a self-expandable or balloon-expandable stent; and{'sup': 2', '2, 'a valve assembly sutured to the stent, the valve assembly comprising a cuff and a prosthetic leaflet composed of a coated or uncoated woven polymer fabric having at least one of: (i) an ultimate tensile strength between 25 MPa and 250 MPa; (ii) a tear strength of between 10 lbF and 40 lbF; (iii) a permeability of between 10 mLcm/min—and 1,200 mLcm/min; (iv) a suture retention of between 30 N and 70 N; (v) a stiffness/flexural rigidity of between 0.001 cm and 4 cm; and (vi) a stretch of between 3% and 50%,'}wherein the prosthetic leaflet has a thickness of between about 5 μm and about 500 μm and the cuff has a thickness of between about 1 μm and about 300 μm.2. The replacement heart valve of claim 1 , wherein the cuff or prosthetic leaflet further comprises:(i) a wire attached to a major surface of the woven polymer fabric or a coating layer on the woven polymer fabric;(ii) a stitch through the woven polymer fabric, wherein the stitch does not attach the leaflet or the cuff to another structure;(iii) a suture line through the woven polymer fabric, wherein the suture line does not attach the leaflet or the cuff to another structure;(iv) an area of the woven polymer fabric having a greater weave density than other portions thereof; or(v) a grommet through the woven polymer fabric.3. The replacement heart valve of claim 1 , wherein the replacement heart valve is configured to replace or repair a native aortic valve.4. The replacement heart valve of claim 1 , wherein the replacement heart valve is configured to replace or repair a native mitral valve.5. ...

ANTI-THROMBOGENIC MEDICAL DEVICES

Medical devices that include a tubular member with a plurality of braided filaments, each filament crossing another of the filaments at a respective crossing point forming sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm, the pores have an average pore size that is less than or equal to about 500 microns when the tubular member is in an expanded state, the filaments possessing antithrombogenic surfaces to increase antithrombogenicity of the medical device with pores substantially free of webs formed by antithrombogenic material, such that fewer than 5% of the crossing points have webs formed by antithrombogenic material thereby permitting the pores to be substantially free of webs. 135-. (canceled)36. A medical device for treating an aneurysm , comprising:a tubular member comprising a plurality of braided filaments that form a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is in an expanded state and positioned in a blood vessel and adjacent to the aneurysm, each of the filaments crossing another of the filaments at a respective crossing point; andan antithrombogenic material distributed over the tubular member such that the pores are substantially free of webs formed by the material, and such that webs are present at fewer than about 5% of the crossing points;wherein the crossing points form angles between about 75 degrees and about 105 degrees when the tubular member is in the expanded state.37. The medical device of claim 36 , wherein a thickness of the antithrombogenic material at the crossing points is less than twice a thickness of the antithrombogenic ...

SYSTEMS AND METHODS FOR INCONTINENCE CONTROL

A system for managing female incontinence includes a body of biocompatible material configured to fit between the labia minora and the vestibule floor, the body having a surface configured to occlude the urethral meatus, an adhesive carried on at least a first portion of the surface and configured to provide a sealing engagement between the body and the urethral meatus, and a substance carried by at least one of the body and the adhesive and configured for controlling the odor of the general vaginal-urethral area of a female.

Small Diameter Vascular Graft Produced by a Hybrid Method

The present invention relates to a hybrid graft and methods of generating the hybrid graft. The hybrid graft comprises an exterior surface and a luminal surface. The luminal surface comprises a micropattern of grooves to which cells adhere and orient along. The exterior surface comprises electrospun microfibers wherein the microfibers provide mechanical properties to the graft. The hybrid graft is capable supporting endothelial cell attachment, endothelial cell alignment, cell proliferation, and maintaining their in vivo function. The graft of the invention can recapitulate the in vivo morphology and function of natural vascular endothelium.

METHOD FOR USE OF A DOUBLE-STRUCTURED TISSUE IMPLANT FOR TREATMENT OF TISSUE DEFECTS

A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand alone secondary scaffold implant or unit for treatment of tissue defects. 1. A method for use of a double-structured tissue implant (DSTI) for treatment of a tissue defect , said method comprising steps:a) obtaining or preparing the DSTI comprising a primary scaffold and a secondary scaffold integrated into said first scaffold wherein said primary scaffold is a porous structure prepared from collagen or a collagen-containing material, said porous structure comprising randomly or non-randomly organized pores, said primary scaffold providing a structural support for the secondary scaffold incorporated therein;b) preparing a tissue defect for implantation of said DSTI;c) cutting or trimming the DSTI into a size of the tissue defect;d) rehydrating said DSTI with a physiologically acceptable solution, collagen-containing solution, buffer or saline;e) implanting said DSTI into said defect; andf) covering said implanted DSTI with a tissue adhesive.2. The method of wherein said collagen or collagen-containing material for preparation of the primary scaffold is selected from the group consisting of Type I collagen claim 1 , Type II collagen claim 1 , Type III collagen claim 1 , Type IV collagen claim 1 , Type V collagen claim 1 , gelatin claim 1 , collagen-containing agarose claim 1 , collagen-containing hyaluronan claim 1 , collagen-containing proteoglycan claim 1 , collagen-containing glycosaminoglycan claim 1 , collagen-containing glucosamine claim 1 , collagen-containing galactosamine claim 1 , collagen-containing glycoprotein claim 1 , collagen-containing fibronectin claim 1 , collagen- ...

STENT

A stent is disclosed herein. The stent includes a silicon cover, a plurality of cylindrical members, and connection members. The silicon cover is formed in an open hollow cylindrical shape in which the diameter of both ends thereof is larger than the diameter of the intermediate portion thereof. The plurality of cylindrical members is disposed on the outer circumference of the silicon cover in a hollow cylindrical shape whose both ends are open, and is configured such that the diameter thereof is reduced by external force to be installed in a tubule. The connection members connect facing ones of the plurality of cylindrical members at regular intervals in a single ring shape between the cylindrical members, and have elasticity in a lengthwise direction. 1. A stent , comprising:a silicon cover formed in an open hollow cylindrical shape in which a diameter of both ends thereof is larger than a diameter of an intermediate portion thereof;a plurality of cylindrical members mounted on an outer circumference of the silicon cover in a hollow cylindrical shape whose both ends are open, and configured such that a diameter thereof is reduced by external force to be installed in a tubule; andconnection members configured to connect facing ones of the plurality of cylindrical members at regular intervals in a single ring shape between the cylindrical members and to have elasticity in a lengthwise direction.2. The stent of claim 1 , wherein the cylindrical members are each fabricated by disposing one or more lines along a circumferential surface in a zigzag shape to form a plurality of peak parts and a plurality of valley parts.3. The stent of claim 2 , wherein the connection members connect most adjacent peak and valley parts of facing ones of the cylindrical members.4. The stent of claim 1 , wherein the connection members comprise at least three connection members that are connected along circumferences of the cylindrical members.5. The stent of claim 4 , wherein the ...

Interpositional Joint Implant

A method of preparing an interpositional implant suitable for a knee. The method includes determining a three-dimensional shape of a tibial surface of the knee. An implant is produced having a superior surface and an inferior surface, with the superior surface adapted to be positioned against a femoral condyle of the knee, and the inferior surface adapted to be positioned upon the tibial surface of the knee. The inferior surface conforms to the three-dimensional shape of the tibial surface. The implant may be inserted into the knee without making surgical cuts on the tibial surface. The tibial surface may include cartilage, or cartilage and bone.

MEDICAL IMPLANTS COMPRISING ANTI-INFECTIVE SURFACES

A medical implant comprising: ⋅an implant body configured for use as a medical implant, ⋅a surface on the implant body, ⋅wherein the surface comprises a plurality of projections (), each projection having a base proximal to the implant body, a peak distal to the implant body, and a side wall extending from the base to the peak, ⋅wherein the surface has a peak density in a range 50 to 500 peaks per 11 m, and ⋅wherein the projections are tapered such that a width at the peak of each projection is less than a width at the base of each projection. 1. A medical implant comprising:an implant both configured for use as a medical implant,a surface on the implant body,wherein the surface comprises a plurality of projections, each projection having a base proximal to the implant body, a peak distal to the implant body, and a side wall extending from the base to the peak,wherein the surface has a peak density in a range 50 to 500 peaks per μm2, andwherein the projections are tapered such that a width at the peak of each projection is less than a width at the base of each projection.2. A medical implant according to claim 1 ,wherein the peak density is greater than 100, 150, or 200 peaks per μm2.3. A medical implant according to claim 1 ,wherein the peak density is less than 400, 300, or 250 peaks per μm2.4. A medical implant according to claim 1 ,wherein the surface has a kurtosis in a range 2.50 to 4.00.5. (canceled)6. (canceled)7. A medical implant according to claim 1 ,wherein the surface has a skewness in a range −0.20 to +0.30.8. (canceled)9. (canceled)10. A medical implant according to claim 1 ,wherein the surface has a surface roughness (Ra) in a range >5 nm to 18 nm.11. A medical implant according to claim 10 ,wherein the surface roughness (Ra) of the surface is greater than 6 nm, 7 nm, or 7.5 nm.12. A medical implant according to claim 10 ,wherein the surface roughness (Ra) of the surface is less than 14 nm, 12 nm, 10 nm, or 9 nm.13. A medical implant according to ...

PROMOTING ENDOTHELIAL CELL AFFINITY AND ANTITHROMBOGENICITY OF POLYTETRAFLUOROETHYLENE (PTFE) BY MUSSEL-INSPIRED MODIFICATION AND RGD/HEPARIN GRAFTING

Disclosed herein are methods for modifying a substrate having a hydrophobic surface. Also disclosed are modified hydrophobic substrates. The modified hydrophobic substrates and methods disclosed herein advantageously improve cell affinity and antithrombogenicity of hydrophobic surfaces. 1. A method for modifying a hydrophobic surface , the method comprising: treating the hydrophobic surface with oxygen plasma to form an oxygen plasma-treated surface; coating the oxygen plasma-treated surface with a solution comprising dopamine to form a dopamine-coated surface; coating the dopamine-coated surface with a solution comprising polymer comprising a terminal amine to form a polymer coating on the dopamine-coated surface; and immobilizing a bioactive molecule on the polymer coating by contacting the bioactive molecule with the polymer coating.2. The method of wherein the hydrophobic surface comprises polytetrafluoroethylene (PTFE) claim 1 , poly (lactic acid) (PLA) claim 1 , poly (lactic-co-glycolic acid) (PLGA) claim 1 , poly (ε-caprolactone) (PCL) claim 1 , polyurethane (PU) claim 1 , polypropylene carbonate (PPC) claim 1 , polyhydroxybutyrate (PHB) and combinations thereof.3. The method of claim 1 , wherein the polymer comprising a terminal amine is present in the solution in an amount ranging from about 0.1 mg/mL to about 1 mg/mL.4. The method of claim 1 , wherein the immobilizing a bioactive molecule comprises immobilizing at least two bioactive molecules.5. The method of claim 4 , wherein the at least two bioactive molecules comprises a cell adhesion molecule and an anticoagulant.6. The method of claim 1 , wherein the bioactive molecule is a cell adhesion molecule selected from the group consisting of fibronectin claim 1 , arginine-glycine-aspartic acid (RGD) peptide claim 1 , arginine-glycine-aspartic acid-serine (RGDS) peptide claim 1 , leucine-aspartic acid-valine (LDV) peptide claim 1 , fibronectin CS1 region claim 1 , laminin claim 1 , tyrosine-isoleucine- ...

SYSTEMS AND METHODS FOR INCONTINENCE CONTROL

A system for managing female incontinence includes a body of biocompatible material configured to fit between the labia minora and the vestibule floor, the body having a surface configured to occlude the urethral meatus, an adhesive carried on at least a first portion of the surface and configured to provide a sealing engagement between the body and the urethral meatus, and a substance carried by at least one of the body and the adhesive and configured for controlling the odor of the general vaginal-urethral area of a female. 1a body of biocompatible material configured to fit between the labia minora and the vestibule floor, the body having a surface configured to occlude the urethral meatus;an adhesive carried on at least a first portion of the surface and configured to provide a sealing engagement between the body and the urethral meatus; anda substance carried by at least one of the body and the adhesive and configured for controlling the odor of the general vaginal-urethral area of a female.. A system for managing female incontinence comprising: This application is a continuation of U.S. patent application Ser. No. 16/174,680, filed on Oct. 30, 2018, which is a continuation of U.S. patent application Ser. No. 15/706,596, filed on Sep. 15, 2017, issued as U.S. Pat. No. 10,143,772. which is a continuation of U.S. patent application Ser. No. 15/206,157, filed on Jul. 8, 2016, issued as U.S. Pat. No. 9,795,705, which is a continuation of U.S. patent application Ser. No. 14/870,104, filed on Sep. 30, 2015, issued as U.S. Pat. No. 9,408,684, which claims the benefit of priority to U.S. Provisional App. No. 62/059,833, filed on Oct. 3, 2014, all of which are incorporated by reference in their entirety herein for all purposes. Priority is claimed pursuant to 35 U.S.C. § 120 and 35 U.S.C. § 119.The field of the invention generally relates to devices for treating urinary incontinence.Urinary incontinence is a troublesome problem for many individuals. Urinary stress ...

Implantable tissue repair devices and methods for manufacturing the same

Spine disc

Stent

스텐트의 방사 방향으로의 확장 변형에 수반되는 약제 코트층에서의 변형의 발생이나 응력 집중을 최대한 회피하여, 약제가 탈락할 우려가 없는 스텐트를 제공한다. 스텐트 본체(2)의 외측 표면에 코팅되는 약제 코트층(4)의 두께 B를 굴곡부 K를 향해 점감하여, 스텐트(1)의 확장 변형에 수반되는 약제 코트층(4)에서의 변형이나 응력을 저감시켜, 약제의 탈락을 회피하는 것을 특징으로 한다. There is provided a stent in which the occurrence of deformation or concentration of stress in the drug coat layer caused by expansion and contraction of the stent in the radial direction is avoided as much as possible and the drug is not likely to fall off. The thickness B of the medicine coat layer 4 coated on the outer surface of the stent body 2 is decreased toward the curved portion K so that deformation or stress in the medicine coat layer 4 caused by expansion and contraction of the stent 1 And the drug is prevented from dropping out.

椎间植入物和椎间植入物与插入椎间植入物的器械的系统

提供一种椎间植入物，其包括：主体，其具有配置成接合第一椎体终板的上壁和配置成接合第二椎体终板的下壁，以及负荷传递部件，其配置成在上壁和下壁之间传递负荷；其中负荷传递部件配置成呈压缩状态和膨胀状态，在压缩状态下上壁和下壁之间的距离限定植入物的第一高度，在膨胀状态下上壁和下壁之间的距离限定大于第一高度的植入物的第二高度；其中负荷传递部件在至少两个连接位置上附连到上壁并且在至少两个连接位置上附连到下壁并且在植入物的前视图中具有大致X形状；并且其中植入物由具有形状记忆性质的材料制造，其允许植入物在没有作用于它的外力的情况下保持在压缩状态并且响应将温度引导到恢复水平而变化到膨胀状态。

Implant and element thereof

FIELD: medicine. SUBSTANCE: implant comprises an attachment to a human or animal living biological tissue. The implant has an external surface containing the first part and the second part which have different properties in relation to biocompatibility of each part with a biological tissue. The implant contains at least one surface patch containing a base surface forming said first part, and one or more limited areas forming said second part, and said one or more limited areas consist of a set of the limited zones more than five in number. The method for making said implant starts with equipping the implant with a perforated covering device, and applying said one or more limited areas outside of the covering device in the form of deposited layer so that notches in the covering device limit said second part of the surface. The method for making said implant starts with coating the implant and equipping it with the perforated covering device, and removing said coating from the notch zones of the covering device to provide said one or more limited areas. The covering device is designed to be used in the methods described above. An element of the implant contains comprises an attachment to a human or animal living biological tissue, herewith the implant has the external surface containing at least one surface area with a topographically modified surface. The attachment is supplied with at least one thread; the surface area is located in a profile valley of said at least one thread, and relief processed by making a number of recesses. Said recesses follow each other along the longitudinal length of the profile valley of said at least one thread. The method for making said element of the implant consists that laser generates said surface topography. EFFECT: invention enables the implant to be adapted to interact with the biological tissue so making the implant with the surface possessing bioactive properties which thus interacts with the surrounding tissue and is ...

Films and methods of manufacture

본 발명의 실시 형태들은 천공 중합체 필름 및 이의 제조 방법에 관한 것이다. 일부 실시 형태에서, 필름은 이식가능한 의료 장치와 함께 사용하기 위한 것이다. 일 실시 형태에, 제1 표면 및 반대편의 제2 표면을 갖는 중합체 필름을 포함하는, 가요성 본체가 있으며, 상기 필름은 제1 표면으로부터 제2 표면까지 연장되는 복수의 개구들, 및 복수의 융기된 립들로서, 복수의 개구들 각각이 복수의 융기된 립들 중 하나에 의해 둘러싸이도록 제1 표면으로부터 돌출되는, 상기 복수의 융기된 립들을 갖는다. 일 실시 형태에서, 필름은 단일 층을 포함하고, 다른 실시 형태에서, 필름은 복수의 층들을 포함한다. 소정 실시 형태에서, 필름은 접착제 층을 포함할 수 있다. 다른 실시 형태에서, 층들 중 하나 이상은 약물 함유 층 및/또는 약물 방출을 위한 속도 제어 층일 수 있다. Embodiments of the present invention relate to perforated polymer films and methods of making the same. In some embodiments, the film is for use with an implantable medical device. In one embodiment, there is a flexible body comprising a polymer film having a first surface and an opposite second surface, the film having a plurality of openings extending from the first surface to the second surface, and a plurality of ridges. Raised lips, wherein each of the plurality of openings protrudes from the first surface so as to be surrounded by one of the plurality of raised lips. In one embodiment, the film comprises a single layer, and in another embodiment, the film comprises a plurality of layers. In certain embodiments, the film may include an adhesive layer. In other embodiments, one or more of the layers may be a drug containing layer and/or a rate controlling layer for drug release.

Prosthesis with resorbable collar

An articulating hemiarthroplasty prosthesis (10) for use in arthroplasty is provided. The prosthesis includes a stem (12) for implantation at least partially within the medullary canal (14) of a long bone (16) and a collar (20). The collar (20) is operably associated with the stem (12) and extends outwardly therefrom. At least a portion of the collar (20) includes a resorbable material. The prosthesis includes a head (30) and a cup (46) for engagement with the head (30).

Prosthesis with resorbable collar

A articulating hemiarthroplasty prosthesis ( 10 ) for use in arthroplasty is provided. The prosthesis includes a stem ( 12 ) for implantation at least partially within the medullary canal ( 14 ) of a long bone ( 16 ) and a collar ( 20 ). The collar ( 20 ) is operably associated with the stem ( 12 ) and extends outwardly therefrom. At least a portion of the collar ( 20 ) includes a resorbable material. The prosthesis includes a head ( 30 ) and a cup ( 46 ) for engagement with the head ( 30 ).

Prosthesis with resorbable collar

An articulating hemiarthroplasty prosthesis ( 10 ) for use in arthroplasty is provided. The prosthesis includes a stem ( 12 ) for implantation at least partially within the medullary canal ( 14 ) of a long bone ( 16 ) and a collar ( 20 ). The collar ( 20 ) is operably associated with the stem ( 12 ) and extends outwardly therefrom. At least a portion of the collar ( 20 ) includes a resorbable material. The prosthesis includes a head ( 30 ) and a cup ( 46 ) for engagement with the head ( 30 ).

Inflatable device and method for reducing bone and spinal injury

Medical devices with drug-eluting coating

Medical devices, such as endoprostheses, and methods of making the devices are described. In one embodiment, a medical device having a body of interconnected bands and connectors forming an elongated tubular structure having an inner luminal wall surface, an outer abluminal wall surface and a side wall surface, and defining a central lumen or passageway, wherein said inner luminal wall surface and side wall surface of the bands and connectors form transverse passageways through the elongated tubular structure is described. One or more wall surfaces of the tubular structure can bear a coating whose selected regions define at least one depression. The coating can further include at least one biologically active substance.

Medical devices with drug-eluting coating

Medical devices, such as endoprostheses, and methods of making the devices are described. In one embodiment, a medical device having a body of interconnected bands and connectors forming an elongated tubular structure having an inner luminal wall surface, an outer abluminal wall surface and a side wall surface, and defining a central lumen or passageway, wherein said inner luminal wall surface and side wall surface of the bands and connectors form transverse passageways through the elongated tubular structure is described. One or more wall surfaces of the tubular structure can bear a coating whose selected regions define at least one depression. The coating can further include at least one biologically active substance.

Medical implant for gas exchange

Die Erfindung betrifft ein medizinisches Implantat zur Behandlung von Knochendefekten aufweisend einen Hohlkörper (1), der einen Innenraum im Inneren des Hohlkörpers (1) begrenzt, eine Fluidzuleitung (2), die mit dem Innenraum des Hohlkörpers (1) fluiddurchlässig verbunden ist, eine Fluidableitung (3), die mit dem Innenraum des Hohlkörpers (1) fluiddurchlässig verbunden ist, wobei der Hohlkörper (1) zumindest bereichsweise oder vollständig aus zumindest einem Kunststoff besteht, wobei der zumindest eine Kunststoff für Flüssigkeiten undurchlässig ist und für Sauerstoff und für Kohlendioxid durchlässig ist, so dass Sauerstoff aus einem durch den Hohlkörper (1) geleiteten Fluid an die Umgebung des Hohlkörpers (1) abgebbar ist und Kohlendioxid aus der Umgebung des Hohlkörpers (1) in das Fluid aufnehmbar ist.Die Erfindung betrifft auch ein Knochendefektbehandlungssystem aufweisend ein solches medizinisches Implantat und das Fluid, wobei das Fluid Sauerstoff enthält und zur Aufnahme von Kohlendioxid geeignet ist, und ein Verfahren zum Begasen einer Oberfläche eines medizinischen Implantats. The invention relates to a medical implant for treating bone defects, comprising a hollow body (1) which delimits an interior space in the interior of the hollow body (1), a fluid supply line (2) which is connected to the interior of the hollow body (1) in a fluid-permeable manner, a fluid discharge line (3), which is connected to the interior of the hollow body (1) in a fluid-permeable manner, the hollow body (1) at least partially or completely consisting of at least one plastic, the at least one plastic being impermeable to liquids and permeable to oxygen and carbon dioxide so that oxygen can be released from a fluid passed through the hollow body (1) to the surroundings of the hollow body (1) and carbon dioxide can be absorbed into the fluid from the surroundings of the hollow body (1). The invention also relates to a bone defect treatment system having such a medical one The ...

Pre-assembled bioprosthetic valve and sealed conduit

A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection.

Pre-assembled bioprosthetic valve and sealed conduit

A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection.

Novel hydrogel tissue expanders

본 발명은 건조 상태에서 탄성이 있는 생분해성 화학적 가교화 하이드로겔을 포함하는 조직 확장제를 제공한다. 이들 생체적합성 조직 확장제는 자기 팽윤성이며, 막이 없다. 이들은 매립 시 외과의에 의한 신속하고 손쉬운 조작이 가능한 동시에 서서히 팽윤하고, 최소한의 부정적인 조직 반응을 유도한다. The present invention provides a tissue expander comprising a biodegradable chemically crosslinked hydrogel that is elastic in a dry state. These biocompatible tissue expanders are self-swelling and membraneless. They swell slowly and induce minimal adverse tissue reactions while allowing for rapid and easy manipulation by the surgeon upon embedding.

Abluminal stent coating apparatus and method using a brush assembly

The apparatus and method use an optical feedback system to align a brush assembly with a stent strut. Once alignment is achieved, a coating is dispensed onto the stent strut via the brush assembly and the brush assembly is moved along the stent strut to coat the stent strut.

Preparation method of bionic artificial bone scaffold having mechanical gradient

本发明公开了一种具有力学梯度仿生人工骨支架的制备方法。该方法首先将人工骨支架CAD模型由下至上均匀分割成N层截面并将每层截面由里到外分为四部分，然后将羟基磷灰石、明胶、生物粘结剂等材料按四种不同比例混合成打印原材料。最后将四种不同比例的混合材料依次有序地挤压打印到每层截面的四部分中。在本发明中，由于每层截面各部分使用的打印原材料各组分比例不同，从而使得各部分具有不同的力学性能，利用此方法制备的人工骨支架具有更好的力学性能和梯度。

Mesh sheet with microscopic projections and holes

A porous mesh for use in forming articles comprising a network of pores and protrusions. The porous mesh has a specifically delineated mesh structure having a pore/protrusion size between 25 and 1000 microns and the pore structure is based on a uniform distribution of pores and protrusions on a cast or molded sheet wherein said pores and protrusions have similar effective diameters. The resulting material is advantageously applied to several bio-medical applications, including reconstructive surgery and arterial replacement

Crosslinkable biological material and medical uses

A method for promoting angiogenesis in a patient comprising providing crosslinkable biological solution to the target tissue, wherein the crosslinkable biological solution is loaded with at least one angiogenic agent. In one embodiment, the at least one angiogenic agent is a non-protein factor selected from a group consisting of ginsenoside Rg 1 , ginsenoside Re, combination thereof and the like. In another embodiment, the crosslinkable biological solution of the present invention is broadly defined in a form or phase of solution, paste, gel, suspension, colloid or plasma that may be solidifiable thereafter.

Combined semi-limited bipolar or multipolar artificial wrist joint

本实用新型公开了一种组合式半限定双极或多极人工腕关节，是根据腕关节骨破坏的具体病理情况，如显示掌腕骨关节面完整、骨质尚好，可以保留大部分的远排腕骨(累及小多角骨、头状骨)，而近排腕骨(舟状骨及月骨)及腕挠骨关节面破环，及可行近排腕骨切除之选型组装；该人工腕关节还可以做另一种组配方式，即可称作“半限定多极人工腕关节”，可以对病理破坏的双排腕骨切除，形成掌、腕、挠各关节的互配组装，会给术者带来灵活、方便和理想的手术结果。

Surface treatments for accommodating intraocular lenses and associated methods and devices

An accommodating intraocular lens (AIOL) for implantation within a capsular bag of a patient's eye comprises first and second components coupled together to define an inner fluid chamber and an outer fluid chamber. The inner region of the AIOL provides optical power with one or more of the shaped fluid within the inner fluid chamber or the shape of the first or second components. A surface treatment or coating may be applied to one or more surfaces of the first and second components. The surface treatment is expected to decrease the roughness of the machined surfaces of the boundary surfaces of the first and second components, and thereby reduce the mass of water coalescing at such boundary surfaces. The disclosed surface treatments are also expected to increase the hydrophobicity (i.e., decrease the surface energy) of the corresponding surface(s), thereby decreasing the “wettability” of these surfaces.

Osteosynthesis aids made of a steel, cobalt and / or titanium alloy

Bone material and collagen composition for restoring injured articulations

FIELD: medicine. SUBSTANCE: bone-and-mineral product contains porous bone mineral particles produced from natural bone and having crystalline structure practically corresponding to natural bone structure and practically containing no endogenous organic material. The particles have fibers of physiologically compatible type II resorbable collagen at least on their surface. Mass proportion of type II collagen fibers and porous bone mineral is at least equal to approximately 1:40. EFFECT: enhanced effectiveness in recovering combined injuries of cartilage and bone tissue in articulations having defects. 8 cl, 6 dwg ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß RU (19) (11) 2 292 858 (13) C2 (51) ÌÏÊ A61F A61F A61L A61L A61L 2/28 (2006.01) 2/30 (2006.01) 27/24 (2006.01) 27/36 (2006.01) 27/54 (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà âêà: 2001119843/15, 18.07.2001 (72) Àâòîð(û): ÃÀÉÑÒËÈÕ Ïåòåð (CH), Ø˨ÑÑÅÐ Ëîòàð (DE) (24) Äàòà íà÷àëà îòñ÷åòà ñðîêà äåéñòâè ïàòåíòà: 18.07.2001 (43) Äàòà ïóáëèêàöèè çà âêè: 27.07.2003 R U (73) Ïàòåíòîîáëàäàòåëü(è): ÝÄ. ÃÀÉÑÒËÈÕ Ç¨ÍÅ Àà ÔÞÐ ÕÅÌÈØÅ ÈÍÄÓÑÒÐÈ (CH) (30) Êîíâåíöèîííûé ïðèîðèòåò: 19.07.2000 US 60/219,009 (45) Îïóáëèêîâàíî: 10.02.2007 Áþë. ¹ 4 2 2 9 2 8 5 8 (56) Ñïèñîê äîêóìåíòîâ, öèòèðîâàííûõ â îò÷åòå î ïîèñêå: US 5573771 À 12.11.1996. WO 9625961 A1 29.08.1996. US 4882149 A1 18.12.1986. US 5837278 A1 17.11.1998. RU 2062622 C1 27.06.1996. RU 2104703 C1 20.02.1998. 2 2 9 2 8 5 8 R U (54) ÊÎÑÒÍÛÉ ÌÀÒÅÐÈÀË È ÊÎËËÀÃÅÍÎÂÀß ÊÎÌÏÎÇÈÖÈß ÄËß ÂÎÑÑÒÀÍÎÂËÅÍÈß ÏÎÂÐÅÆÄÅÍÍÛÕ ÑÓÑÒÀÂΠ(57) Ðåôåðàò: Èçîáðåòåíèå îòíîñèòñ ê îáëàñòè ìåäèöèíû. Êîñòíî-ìèíåðàëüíûé ïðîäóêò äë âîññòàíîâëåíè êîìáèíèðîâàííûõ ïîâðåæäåíèé õð ùà è ïîâðåæäåíèé êîñòè âêëþ÷àåò ÷àñòèöû ïîðèñòîãî êîñòíîãî ìèíåðàëà, ïîëó÷åííûå èç íàòóðàëüíîé êîñòè, èìåþùèå êðèñòàëëè÷åñêóþ ñòðóêòóðó, ïðàêòè÷åñêè ñîîòâåòñòâóþùóþ ñòðóêòóðå íàòóðàëüíîé êîñòè, è ïðàêòè÷åñêè íå ñîäåðæàùèå êàêîãî-ëèáî ýíäîãåííîãî îðãàíè÷åñêîãî ...

Novel hydrogels tissue expander

本发明提供组织扩张器，其包含生物可降解的、化学交联的水凝胶，该水凝胶在干燥状态下是弹性的。这些生物相容的组织扩张器是自膨胀且不含膜的。它们缓慢溶胀，且引发最小程度的负面组织应答，并且允许由外科医生在置放时进行快速且简易的操作。

Glue for cartilage repair

The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers with allogenic chondrocytes or bone marrow cells in an amount exceeding the natural occurrence of same in hyaline cartilage and adding a cell growth additive.

Cartilage allograft plug

The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.

Cartilage allograft plug

The invention is directed toward a cartilage repair assembly comprising a cylindrically shaped allograft structure of subchondral bone with an integral overlying smaller diameter cartilage cap which is treated to remove cellular debris and proteoglycans. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the subchondral bone of the structure engages the side wall of the bone portion of the drilled bore in an interference fit while the cartilage cap is spaced from cartilage portion of the side wall of the drilled bore forming a gap in which a milled cartilage and biocompatible carrier mixture is placed allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.

Bone anchor prosthesis and system

A prosthetic screw system that includes a prosthetic screw for at least partial insertion into a bone and/or cartilage. The prosthetic screw includes a head and a lower portion connected to the head. The prosthetic screw system also includes a set of head-pieces that can be connected to the head of the prosthetic screw. The head-pieces have differing configurations that are designed to be connected to different types of components of a prosthetic system. The universal connection arrangement between the prosthetic screw and the set of head-pieces enables the prosthetic screw to be customized for connection with a variety of components of a prosthetic system. The head-pieces can alternatively or additionally include a mechanical and/or electrical mechanism that provides one or more substances (e.g., medicine and/or other biological agent, etc.) and/or electrostimulation to a surgical site.

Novel hydrogel tissue expanders

The present invention provides tissue expanders comprising biodegradable, chemically cross-linked hydrogels which are elastic in the dry state. These biocompatible tissue expanders are self-inflating and membrane-free. They swell slowly and elicit minimal negative tissue responses, while allowing for rapid and easy manipulation by the surgeon at the time of emplacement.

Devices and methods for treating defects in the tissue of a living being

An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant comprising collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may be “matched” to provide the implant with similar physical and/or chemical properties as the host tissue.

Bioabsorbable filamentary medical device

本公开的各种方面涉及包括细丝和围绕细丝设置的隔膜的设备、系统和方法。隔膜可构造成保持细丝的碎屑并响应于细丝的断裂或降解而维持隔膜的结构。

How to pool organizations

(57)【要約】 本発明は、移植を必要としているレシピエントに移植する前に処理するために、組織を安全で効果的に且つ効率的にプールする新規の方法を含む。一態様において、本発明は、移植片の孔内に望ましい因子を効率的に浸透させると同時に、移植片の孔から望ましくない因子を除去させる多孔性移植片を灌流する段階と、移植片を洗浄する段階と、移植片を効率的に不動態化する（病原菌、微生物、細胞、ウイルス等の不活性化およびそれらの抗原性の低下）段階と、このような処理によって作製される新規移植片とを含む。本発明の方法は、圧力周期化の速度、圧力周期の事実および圧力周期の振幅により移植するための組織および他の移植片が高度に清浄化されるシステムを提供する。本発明の方法の標的汚染除去目標には、細菌汚染の約1〜12 log減少、外膜ウイルス汚染の約1〜15 log減少、非外膜ウイルス汚染の約5 logまでの減少、内毒素の約2〜10倍の減少、移植片または移植片の生物的特性および生体力学特性の維持、清浄液の使用による組織毒性の除去並びに移植片の低い抗原性が含まれる。

Stent

A stent has a circumference and a plurality of members that define a lumen. The stent has three stable states, which include an unexpanded state, a partially deployed state, and a deployed state The lumen has a first cross-sectional shape in the unexpanded state, a second cross-sectional shape in the partially deployed state and a third cross-sectional shape in the deployed state The first cross-sectional shape of the lumen is different from the second and third cross-sectional shapes of the lumen, and the first cross-sectional shape of the lumen is a non-round shaped cross-sectional shape