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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 1773. Отображено 100.
15-11-2012 дата публикации

Automated Reservoir Fill System

Номер: US20120289900A1
Автор: Arsen Ibranyan, Colin A. Chong, Edgardo C. Halili, Eric M. Lorenzen
Принадлежит: Medtronic Minimed Inc

An automated reservoir filling system for a portable medical device is disclosed. The system includes a vial sealed by a septum partially filled with a liquid and a gas occupying a headspace. The system further includes a reservoir with a volume defined between a reservoir septum and a plunger head. The plunger head is coupled to a plunger arm which is further coupled to a drive system. Further included is a transfer system with a vial end that pierces the vial septum and remains in contact with the liquid, and a reservoir end that pierces the reservoir septum and remains in the reservoir volume. A controller coupled to the drive system to actuates the drive system automatically drawing fluid from the vial to the reservoir through the degas system.

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Номер записи: 1
25-04-2013 дата публикации

Dispensing insert for a medicine containment and dispensing system and associated method

Номер: US20130102989A1
Автор: Gordon Beecroft, John VASSALLO, Matthew P. Franks, Michael MAKHLOUF, Ryan P. McCoy, Stacy Abel
Принадлежит: Target Brands Inc

A dispensing insert is configured to friction fit within a neck of a bottle and to selectively receive an oral syringe. The dispensing insert includes a hollow cylinder, a top plate capping one end of the hollow cylinder, a raised deck extending substantially parallel to and spaced from the top plate, and an annular side wall extending from the top plate upwardly toward the raised deck. The raised deck has a smaller outer diameter than the top plate and defines an opening therethrough configured to provide access to contents of the pharmacy bottle through the dispensing insert. The annular sidewall substantially encompasses an outer perimeter of the raised deck.

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Номер записи: 2
18-07-2013 дата публикации

Medical Device Connector

Номер: US20130184672A1
Автор: Alexander CEDERSCHIÖLD, LARS Nord
Принадлежит: Carmel Pharma AB

The present invention relates to a medical device connector for connecting a piercing device ( 3 ), with a vial ( 2 ) comprising a base member. A plurality of grip members ( 50 ), each grip member ( 50 ) comprising a distal end (D) and a proximal end (P) and each comprising a wedge portion ( 61 ) adapted to temporarily or permanently lock the medical device connector ( 1 ) to the vial ( 2 ). The base member ( 30 ) further comprises a plurality of flanges ( 40 ), wherein the proximal ends (P) of the grip members ( 50 ) are arranged to the flanges ( 41, 40 ). The flanges ( 40 ) extend substantially out from the periphery of the base member ( 30 ) in a direction substantially perpendicular to the direction of the grip members, wherein the space formed between the flanges ( 40 ) of the base member ( 30 ) forms at least one grip portion. The present invention provides for a medical device connector ( 1 ) which is easy and comfortable to use, which provide good stacking capabilities and which permits a user to readily acknowledge that the medical device connector ( 1 ) is correctly assembled with the vial ( 2 ).

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Номер записи: 3
07-01-2021 дата публикации

FILL AND FINISH SYSTEMS AND METHODS

Номер: US20210002008A1
Автор: Griep Julie, Min Kyungyoon, Salomon Alexandra, Wegener Christopher J.
Принадлежит:

A variety of fill options is provided for a cell processing system. Certain options relate to a filling system associated with the cell processing system, the filling system comprising one or more filling stations, each with at least one container that may receive product from a container associated with a cell processing system. Other options relate to a syringe assembly that receives a product from a container associated with a cell processing system. 1. A filling system comprising:a transfer set connectable to a source container;a plurality of filling stations each comprising at least one flexible walled container connected to the transfer set and in selective fluid communication with the source container via the transfer set;a syringe pump connected to the transfer set, and configured to transfer a product from the source container to the at least one flexible walled container via the transfer set; anda controller coupled to the plurality of filling stations and the syringe pump, the controller configured to operate each of the plurality of filling stations and the syringe pump in concert to transfer a constant volume of fluid from the source container to the at least one container of each of the plurality of filling stations.2. The filling system according to claim 1 , wherein the controller is configured to operate the syringe pump to correct for variances in distance between the syringe pump and each of the plurality of filling stations.3. The filling system according to claim 1 , wherein:each of the plurality of filling stations comprises a valve that limits or permits fluid communication between the at least one container and the source container, and the controller being configured to open the valve associated with one of the plurality of filling stations, to operate the syringe pump to transfer the constant volume of fluid from the source container to the at least one container of the one of the plurality of filling stations, and to close the valve ...

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Номер записи: 4
14-01-2021 дата публикации

Syringe With Connector

Номер: US20210007933A1
Автор: John Di Ubaldi, Sambath Kumar RAJAGOPAL
Принадлежит: Becton Dickinson and Co

A syringe comprising a syringe barrel having a distal end, a distal tip, a proximal end, a barrel sidewall extending between the distal end to the proximal end and defining a chamber, the barrel sidewall having a barrel sidewall thickness t, the distal end of the syringe barrel including a distal wall is disclosed. The syringe includes a connector extending from the syringe barrel including a collar disposed coaxially around an elongate tip in fluid communication with the barrel to form a channel between the elongate tip and the collar, including an inside surface, an outside surface and a plurality of ribs extending radially outwardly from the outside surface and separated by spaces, each of the plurality of ribs having a height H and a width W, wherein there is a ratio of the height H to the barrel sidewall thickness tin a range of 0.75 and 1.

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Номер записи: 5
09-01-2020 дата публикации

MULTI-VOLUME DRUG DELIVERY SYSTEM WITH VACUUM-ASSISTED MIXING AND/OR DELIVERY

Номер: US20200009017A1
Автор: Sharma Vivek K.
Принадлежит:

A multi-chamber drug delivery system includes vacuum chambers to provided vacuum-assisted mixing of first and second desired substances and/or injection of desired substances into a target tissue of a patient. 1. A system for delivery of at least one of a first substance and a second substance to a target body tissue of a patient , comprising:a first chamber having a first vacuum pressure and housing a first substance for delivery to a target body tissue of a patient;a second chamber having a second vacuum pressure and housing a second substance for delivery to a target body tissue of a patient;a first flow control element coupling said first chamber to said second chamber, wherein the first flow control element permits fluid communication from said first chamber to said second chamber;a first vacuum seal, wherein the first vacuum seal, when opened, exposes the first chamber to atmospheric pressure and causes the first substance to be delivered from the first chamber to the second chamber and mixed with the second substance; anda second vacuum seal, wherein the second vacuum seal, when opened, exposes the second chamber to atmospheric pressure and causes the contents of the second chamber to be delivered to the target body tissue of the patient.2. The system of claim 1 , wherein the first flow control element comprises at least one of a one-way check valve claim 1 , a rupturable vacuum seal claim 1 , and a rupturable membrane.3. The system of claim 1 , wherein the first substance and the second substance are selected from a pharmacological agent claim 1 , a diluent for the pharmacological agent claim 1 , and a carrier for the pharmacological agent.4. The system of claim 1 , further comprising a needle coupled to the second chamber claim 1 , wherein the second vacuum seal claim 1 , when opened claim 1 , exposes the second chamber to atmospheric pressure and causes the contents of the second chamber to be delivered to the target body tissue of the patient through the ...

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Номер записи: 6
18-01-2018 дата публикации

SELF SHEATHING ANESTHETIC NEEDLE WITH A DEDICATED SYRINGE

Номер: US20180014996A1
Автор: Asbaghi Hooman
Принадлежит:

A self-sheathing injection assembly that includes a sheath protecting the medical professional from accidental punctures from the needle. The sheath is slidable to expose the end of the needle, and the sheath is lockable in the exposed condition with a detent mechanism. The separable needle assembly also includes features that firmly couples a carpule of medicine to the needle assembly, such that upon removal of the needle assembly after use the carpule remains attached to the needle for simultaneous disposal. 1. A method for dispensing medicine from a container with a syringe , comprising:providing a syringe with compartment, a pump, and a sliding finger hold, and a separable needle assembly including a slidable sheath surrounding the sharp tip;placing the container in the compartment;attaching the needle assembly to the syringe after said placing;engaging the sheath with the finger hold;sliding the finger hold and exposing the sharp tip;locking the finger hold in position with the sharp tip exposed;pumping medicine through the attached needle; andapplying a force with the finger hold to unlock from the position.2. The method of wherein said locking is by interfering contact between the sliding finger hold and a non-sliding surface of the syringe3. The method of which further comprises flexing the finger hold away from the syringe during said sliding.4. The method of wherein said locking includes biasing the sliding finger hold in a direction opposite of the applied force.5. The method of wherein said locking includes biasing the sliding finger hold in a direction toward the sheath surrounding the sharp tip.6. The method of wherein said sliding is in a first direction claim 1 , and said applying is in a different direction.7. A method for dispensing medicine from a container with a syringe claim 1 , comprising:providing a syringe with compartment and a pump, and a separable needle assembly including a container-holding receptacle;placing the container in the ...

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Номер записи: 7
21-01-2016 дата публикации

MULTI-MIX INFUSION BAG

Номер: US20160015889A1
Автор: Caquias Jesus A., Caquias Tomas A.
Принадлежит:

A multi-mix infusion bag is provided. The multi-mix infusion bag includes a lower portion and an upper portion. The lower portion has a lower chamber and the upper portion includes a plurality of chambers. Each chamber is separated and contains a fluid agent. The multi-mix infusion bag is configured to transfer each fluid agent within each chamber of the upper portion into the lower chamber for mixing. The multi-mix infusion bag may include dispensing devices associated with each chamber, wherein the dispensing devices operate to transfer the fluid agents into the lower chamber for mixing.

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Номер записи: 8
16-01-2020 дата публикации

System for Closed Transfer of Fluids

Номер: US20200016036A1
Автор: Sanders Laurie, Zachek Matthew
Принадлежит:

A syringe adapter includes a housing having a first end and a second end with the first end configured to be secured to a first container, a cannula having a first end and a second end with the second end positioned within the housing, and a collet having a first end and a second end with at least a portion of the collet received within the housing. The collet includes a body defining a passageway, a seal member received by the passageway, and an arcuate, resilient locking member connected to the body of the collet. The collet is movable from a first position where the locking member is open to receive a mating connector to a second position where radially outward movement of the locking member is restricted. 1. A syringe adapter comprising:a housing having a first end and a second end, the first end configured to be secured to a first container;a cannula having a first end and second end, the second end of the cannula positioned within the housing; anda collet having a first end and a second end, at least a portion of the collet received within the housing, the collet comprising a body defining a passageway, a seal member received by the passageway, and a locking member, the locking member of the collet is continuous and ring-shaped, the collet is movable from a first position where the locking member is open to receive a mating connector to a second position where radially outward movement of the locking member is restricted.2. The syringe adapter of claim 1 , wherein the locking member of the collet comprises a plurality of notches configured to permit the locking member to expand radially outward.3. The syringe adapter of claim 1 , wherein the locking member is connected to the body via a plurality of arms.4. The syringe adapter of claim 1 , further comprising a connection arrangement having a first connection interface claim 1 , the first connection interface is configured to engage a corresponding connection interface of a mating connector.5. The syringe ...

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Номер записи: 9
10-02-2022 дата публикации

VIAL ADAPTER

Номер: US20220040041A1
Автор: CHENG Marco, PARK Soon, Yeh Jonathan
Принадлежит:

An exemplary vial adapter may include a moveable member, an elongated member with a first passage, a second passage coupled to an expandable first reservoir, and a third passage coupled to an expandable second reservoir. In a first orientation of an exemplary vial adapter, a fluid may be directed through the first passage into the first reservoir or the second reservoir. In a second orientation of an exemplary vial adapter, a fluid may be drawn through the first passage and a fluid drawn through an air passage into the second passage. In a second orientation of an exemplary vial adapter, a fluid may be directed through the first passage and through the third passage into the second reservoir. In a first orientation of an exemplary vial adapter, a moveable member may be activated to direct a fluid from the second reservoir through the third passage. 1. A vial adaptor for coupling with a vial , the vial adaptor comprising:a medical connector interface, a vial interface, an expandable first reservoir, an expandable second reservoir, and a first passage extending from the medical connector interface through the vial interface; the first reservoir comprising a second passage extending through the vial interface and a first valve, wherein the first valve permits movement of a fluid into the first reservoir when the vial adaptor is in an upright orientation, and resists movement of a fluid into the first reservoir when the vial adaptor is moved toward an inverted orientation; and the second reservoir comprising a third passage extending through the vial interface.2. The vial adaptor of claim 1 , wherein the third passage is fluidly separated from the first passage.3. The vial adaptor of claim 1 , further comprising a moveable member configured to engage against the second reservoir to direct a fluid out of the second reservoir.4. The vial adaptor of claim 1 , wherein the second passage comprises a second valve.5. The vial adaptor of claim 1 , further comprising a ...

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Номер записи: 10
24-01-2019 дата публикации

DISPOSAL CONTAINER FOR USED DIALYSATE AND EXTRACORPOREAL BLOOD PURIFICATION SYSTEM COMPRISING SAID DISPOSAL CONTAINER

Номер: US20190021945A1
Автор: ROHDE ALEXANDER
Принадлежит:

A disposal container for used dialysate including a flexible bag in or at which an inlet connection is formed or arranged which is prepared for connecting the bag to a dialysis machine of the mobile type such that the disposal container is movable or displaceable along with the dialysis machine, wherein the disposal container includes an outlet connection or connector provided separately from the inlet connection, the connector being prepared for connecting the bag to a sewer line in a way sealed against the connector environment; and an extracorporeal blood purification system comprising a stationary system area and a non-stationary system area, the system including a bag according to the invention. 17.-. (canceled)8. A disposal container for used dialysate , the disposal container comprising:a flexible bag;an inlet connection formed or arranged in or at the flexible bag to connect the flexible bag to a mobile dialysis machine such that the disposal container is movable or displaceable along with the mobile dialysis machine; andan outlet connection or connector separate from the inlet connection configured to connect the flexible bag to a sewer line at an end of the flexible bag facing away from the flexible bag such that the flexible bag is sealed against an environment of the outlet connection or connector, wherein the outlet connection or connector is formed integrally with the flexible bag.9. The disposal container according to claim 8 , wherein the outlet connection or connector includes an auxiliary connection via which the outlet connection or connector can be coupled to an auxiliary line that is prepared to ensure an increased emptying rate of dialysate from the flexible bag into the sewer line through pressurization.10. The disposal container according to claim 8 , further comprising:a folding mechanism configured to transmit a compressing force to the flexible bag so as to reduce a volume of the flexible bag to ensure an increased emptying rate of ...

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Номер записи: 11
24-01-2019 дата публикации

Primary Packaging for Storage and Administration of Medical and Pharmaceutical Compounds

Номер: US20190021949A1
Автор: SKUFCA Peter
Принадлежит:

A primary packaging for storage and/or administration of medical or pharmaceutical compounds includes a container that has a predetermined filling volume for receiving a medical or pharmaceutical compound. The container is permanently closed at a first end and has an integrally formed, circumferential flange portion at an open second end. The container has a cylindrical barrel that extends between the first end and the flange portion such that the barrel has an inner diameter and outer diameter corresponding to that of a standardized syringe for a nominal volume of the standardized syringe corresponding to the predetermined filling volume. Furthermore, a cross-sectional shape of the flange portion corresponds to the cross-sectional shape of a flange of a standardized vial. The primary packaging also includes a closure element that is adapted to fit tightly on the flange portion and into the barrel for sealing the open second end of the container. 138-. (canceled)39. A device comprising:a container with a cylindrical barrel, a permanently closed first end and an open second end, wherein a circumferential flange is integrally formed at the open second end and has an outer diameter that is larger than an outer diameter of the cylindrical barrel, and wherein the circumferential flange has a cross sectional shape that has a flat upper end surface and a flat lower end surface;a closure element that fits tightly into the open second end of the container; anda needle extraction system having a plunger rod and a cylindrical tube section, wherein a first end of the plunger rod fits into the closure element, wherein the cylindrical tube section has an inner diameter that is larger than the outer diameter of the cylindrical barrel and has a radially outwardly extending finger flange, wherein the finger flange has a radially inwardly extending projection that slides along an outer surface of the cylindrical barrel, and wherein the circumferential flange slides along an inner ...

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Номер записи: 12
23-01-2020 дата публикации

MODULAR DOSING ASSEMBLY OF MEDICAL SUBSTANCES

Номер: US20200022873A1
Автор: Naygauz Mikael
Принадлежит:

Systems, devices and methods to establish fluid communication between vessels. Containers and devices having a unitary multiple entry port structure and a port unitary cover with buttons or levers for the assembly of customized final dosages of injectable beneficial substances. Containers and devices having a protective port with a cover configured to hermetically seal second container(s) within the protective port. A vessel having at least two entry ports and at least one exit port, and at least one container containing a dosing regimen, the at least one container configured to be received by one of the at least two entry ports of the vessel, whereby upon connection of the at least one container to the one of the at least two entry ports of the vessel, the dosing regimen in the at least one container is transferred into the vessel. Modular dosing system for adding at least one amount of a medicament to a preparation in a modular construction. System for displaying a dosing regimen or single amount of a medicament, so that the administrator of the amount is able to precisely ascertain the amount administered to a patient. 1. A system for intermixing beneficial substances , comprising:a first container having a unitary multiple entry port structure, the unitary multiple entry port structure configured to receive a plurality of containers and fully engulf thereof, the unitary multiple port structure further comprising a cover configured to seal the plurality of the containers inside the unitary multiple entry port structure, thereby providing a protective entry port structure; anda plurality of containers containing a beneficial substance, the plurality of the containers configured to enter inside the unitary multiple entry port structure,wherein upon entry of the plurality of the containers inside the unitary multiple entry port structure, the plurality of the containers are completely enclosed inside the unitary multiple entry port structure thus providing for leak- ...

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Номер записи: 13
02-02-2017 дата публикации

Stable Protein Formulations Comprising a Molar Excess of Sorbitol

Номер: US20170028063A1
Автор: CHANDRAMOULI Kala, PAI Rohan
Принадлежит:

A stable pharmaceutical formulation comprising a protein of interest, sorbitol and polyethylene glycol (PEG). The sorbitol and protein is present in a molar ratio of 550 to 700 mole of sorbitol: 1 mole of protein and the PEG to protein is present in the molar ratio of 2-50:1. The formulation optionally comprising buffer. The formulation in lyophilised form is stable for at least 4 years at 2-8° C. Also provided is a process for preparing the composition and a pharmaceutical kit comprising the same. 1. A stable pharmaceutical formulation comprising a protein of interest , sorbitol and polyethylene glycol (PEG) , wherein sorbitol and protein is present in a molar ratio of 550 to 700 mole of sorbitol:1 mole of protein.2. The formulation as claimed in claim 1 , wherein protein and sorbitol are present in a molar ratio of 600 to 660 mole of sorbitol:1 mole of protein claim 1 , preferably in ratio of 631 mole of sorbitol:1 mole of the protein.3. The formulation as claimed in claim 1 , wherein the PEG to protein mole ratio is in a range of 2:1 to 50:1 claim 1 , preferably is 10:1.4. The formulation as claimed in claim 1 , wherein the protein is an antibody.5. The formulation as claimed in claim 4 , wherein the antibody is an anti-HER2 antibody claim 4 , preferably trastuzumab.6. The formulation as claimed in wherein PEG is PEG 33507. The formulation as claimed in claim 1 , which further comprises of a buffer claim 1 , preferably histidine comprising histidine ions.8. The formulation as claimed in claim 1 , wherein the molar concentration of the protein is 0.10 mM to 0.25 mM.9. The formulation as claimed in claim 1 , wherein the molar concentration of sorbitol is 90 mM to 120 mM.10. The formulation as claimed in claim 1 , which is lyophilized or liquid formulation.11. The formulation as claimed in comprising sorbitol claim 1 , PEG 3350 claim 1 , protein and buffer claim 1 , such that sorbitol to protein is in molar ratio of 631: land PEG 3350 to protein is in molar ratio of ...

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Номер записи: 14
18-02-2016 дата публикации

AUTOMATED FILLING SYSTEMS AND METHODS

Номер: US20160045395A1
Автор: KAVAZOV JULIAN D.
Принадлежит:

Various embodiments of the present invention are directed to transferring fluidic media from a vial to a reservoir. In various embodiments, fluidic media may be transferred from the vial to the reservoir by moving a housing portion to move a plunger head located in the reservoir to draw fluidic media from the vial to the reservoir. In other embodiments, fluidic media may be transferred from the vial to the reservoir while the reservoir is held by a holding unit and vibrated by a vibrator to remove air from the fluidic media. In some embodiments, fluidic media may be transferred from the vial to the reservoir by moving a handle operatively connected to a bias member for assisting with the transfer of fluidic media. In other embodiments, the transfer of fluidic media may be assisted by a bias member and a needle connecting atmosphere and the vial. 1. A system for transferring fluidic media , the system comprising:first and second housing portions operatively connected to each other to be moveable relative to each other in a first direction, the first housing portion being selectively connectable with a transfer guard that provides a fluid flow path between a reservoir and a vial, the first and second housing portions defining an interior volume for containing the reservoir when the transfer guard is connected to the first housing portion,the first and second housing portions having an opening through which the reservoir may be passed in a direction transverse to the first direction to be selectively inserted into or removed from the interior volume defined by the first and second housing portions;the second housing portion being operatively engageable to a plunger head in the reservoir when the reservoir is contained in the interior volume defined by the first and second housing portions;the first and second housing portions configured such that fluidic media is transferred between the vial and the reservoir in a case where the reservoir is contained in the interior ...

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Номер записи: 15
18-02-2021 дата публикации

APPARATUS AND METHOD FOR MONITORING AND CONTROLLING THE REMOVAL OF A COVER FROM A SEALED TUBE IN AN ASEPTIC ENVIRONMENT

Номер: US20210047064A1
Автор: DIAZ GUERRERO Carlos Alberto
Принадлежит:

A system is presented for monitoring and controlling in a sterilizable environment the peeling of a cover from a tub sealed by the cover. The system employs a platform having a fiducial source locating structure for holding the tub, a cover removal station disposed to engage with the cover and to peel the cover from the tub, a light source disposed to illuminate a portion of the platform proximate the cover removal station, a light sensor sensitive to light from the light source and disposed to preferentially collect and measure light diffusely reflected from the illuminated portion of the platform, and a controller with software to operate the system. An associated method for monitoring and controlling the peeling of the cover involves moving a peeled portion of the cover into a predetermined peeling monitor zone within the illuminated portion of the platform, and measuring an intensity of light from the light source diffusely reflected specifically from the peeling monitor zone. The positioning of the elements of the system and the peeling monitor zone allow measured light intensity to be employed as a control measure for the peeling process. 1. A system for automatically monitoring and controlling the removing within a sterilizable environment of a cover sealed to a tub , the tub and cover having corresponding pluralities of corners , the system comprising: a source locating structure disposed to hold the tub in a fixed position,', 'a cover removal station disposed to engage with the cover and to peel the cover from the tub,', 'a peeling monitor surface positioned proximate the cover removal station,', 'one or more light sources disposed to illuminate at least a portion of the peeling monitor surface,', 'one or more light sensors sensitive to light from the light source and disposed to collect and measure light diffusely reflected from the illuminated portion of the peeling monitor surface, and, 'a sterilizable chamber capable of maintaining an aseptic condition, ...

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Номер записи: 16
07-02-2019 дата публикации

PICKING DEVICE AND METHOD FOR RETRIEVING DRUG COMPOSITIONS FROM STORAGE

Номер: US20190042701A1
Автор: Hellenbrand Christoph, Wingenter Dirk
Принадлежит:

A picking device for dispensing drug combinations arranged in storage vessels is provided. A storage device includes multiple storage locations for storage vessels, and an operating device is coupled to a controller. A stocking device moves storage vessels into the storage device, and an unloading device transfers drug combinations arranged in the storage vessels to a transport device. 1. A picking device for dispensing drug combinations arranged in storage vessels , comprising:at least one storage device comprising having a plurality of storage locations for storage vessels;an operating device configured to be moved horizontally and vertically in front of a row of shelves, the operating device coupled to a control device;at least one stocking device configured to move storage vessels for drug combinations into the storage device, wherein the operating device is configured to remove the storage vessels therefrom;at least one first identifying device for identifying the drug combinations;an unloading device;at least one delivery station coupled to the control device, the delivery station comprising a removal location and a user interface; anda transport device, coupled to the control device, configured to transfer drug combinations from the unloading device, wherein the transport device connects the storage device to each of the at least one delivery stations, and wherein any of the drug combinations is deliverable to any of the at least one delivery stations.2. The picking device of claim 1 , wherein the unloading device comprises a vessel receptacle having a design corresponding to that of a storage location claim 1 , such that the storage vessels are configured to be deposited by the operating device in the vessel receptacle.3. The picking device of claim 1 , wherein the unloading device is a gravity unloading station by which drug combinations arranged in one of the storage vessels are transferred to the transport device at a receiving location via a discharge ...

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Номер записи: 17
26-02-2015 дата публикации

Formulations of aminoglycosides and fosfomycin in a combination having improved chemical properties

Номер: US20150057241A1
Автор: Alan Bruce Montgomery
Принадлежит: Cardeas Pharma Corp

The present invention is synergistic antibiotic compositions having pH adjusted profiles for manufacturing combination, and administration, particularly for patients at risk or suffering from ventilator-associated pneumonia (VAP) and ventilator associated tracheal (VAT) bronchitis. Antibiotic compositions containing fosfomycin and aminoglycosides having individually predetermined and selected pH ranges are manufactured and stored for in combination prior to aerosolization, preferably with a specially designed in-line nebulizer attached to a ventilator.

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Номер записи: 18
21-02-2019 дата публикации

Devices and methods for the supplementation of a nutritional formula

Номер: US20190053987A1
Автор: FIRST Eric, Widom David
Принадлежит: ALCRESTA THERAPEUTICS, INC.

Exemplary embodiments of the disclosure may be drawn to a device having a vessel configured to contain a source of lipids and a chamber fluidly connected to an outlet of the vessel. The chamber may contain immobilized lipase positioned within a flow path in the chamber along which the lipids flow when released from the vessel into the chamber. The device may also include an outlet through which the lipids flow after passing through the chamber. 1. A device comprising:a vessel configured to contain a source of lipids;a chamber fluidly connected to an outlet of the vessel;immobilized lipase contained within the chamber and positioned within a flow path in the chamber along which the lipids flow when released from the vessel into the chamber; andan outlet through which the lipids flow after passing through the chamber.2. The device of claim 1 , wherein the vessel is sealed except for the outlet.3. The device of claim 1 , wherein the vessel is removably coupled to the chamber.4. The device of claim 1 , wherein the vessel is compressible.5. The device of claim 1 , further comprising a connector fluidly coupled to the outlet claim 1 , wherein the connector includes:a first opening for receiving a flow of fluid;a second opening for outputting the flow of fluid; anda connector flow path extending through the connector from the first opening to the second opening, wherein the connector flow path is fluidly connected to the output assembly.6. The device of claim 5 , further comprising an interface located between the connector and the outlet through which the lipids flow from the outlet and into the connector.7. The device of claim 6 , wherein the interface is removably connected to the connector.8. The device of claim 1 , further comprising a source of lipids contained within the vessel.9. The device of claim 8 , wherein the lipids include two or more different types of lipids.10. A device comprising:a vessel;a source of lipids contained within the vessel;a chamber coupled ...

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Номер записи: 19
27-02-2020 дата публикации

Pressurized Gas Powered Medicament Transfer And Re-Suspension Apparatus And Method

Номер: US20200061292A1
Автор: Dunki-Jacobs Adam, Hooven Michael D., HUDDLESTON Matthew J., Nuchols Richard P., Palmer Joetta Renee, Stefanchik David
Принадлежит:

Apparatus and method are described employing pressurized gas to transfer, mix and/or reconstitute medicament contained in a vial and flowing it into an injection device. Pressurized gas may be provided by prefilled cartridge. 1. A method of transferring fluid from a fluid-containing vial to an injection device comprising:introducing pressurized gas into a vial;flowing fluid from the vial under pressure from the gas;flowing the fluid from the vial into an injection device under the force of the pressurized gas.2. The method of including combining a medicament with the fluid after flowing the fluid from the vial and before flowing the fluid into an injection device.3. The method of in which the combining step includes flowing the fluid from the vial under pressure from the gas into a second vial containing medicament claim 2 , and the step of the flowing fluid into an injection device comprises flowing combined fluid and medicament from the second vial into an injection device under the force of pressurized gas.4. The method of wherein the fluid is a diluent.5. The method of wherein the fluid is a first liquid medicament and the medicament in the second vial is a second liquid medicament.6. The method of in which the medicament in the second vial is lyophilized claim 3 , and the diluent reconstitutes the medicament.7. The method of in which the injection device includes an expandable reservoir claim 1 , and the fluid is flowed into the expandable reservoir under pressure from the pressurized gas.8. The method of in which the expandable reservoir comprises an elastomeric bladder.9. The method of in which the reservoir is biased to expel the fluid or combined diluent and medicament.10. The method of in which pressurized gas is flowed from a pre-filled pressure vessel.11. The method of in which the vessel includes a puncturable seal and the method includes puncturing the seal.12. The method of in which the pressurized gas is essentially pathogen free.13. The method of ...

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Номер записи: 20
27-02-2020 дата публикации

Self-Admixing Disposable Hypodermic Needle

Номер: US20200061294A1
Автор: Pounds William E., Streeter Jason
Принадлежит:

A self-admixing disposable hypodermic needle (admixing needle) includes a reservoir containing an additive, such as a buffering agent, to facilitate homogeneous mixing of the additive with an injection fluid, such as Lidocaine, contained in a cartridge held within a mechanically conjoined syringe. The admixing needle establishes a fluid communication pathway for hypodermically delivering the injection mixture to a patient preceding a potentially painful dental or medical procedure. Prior to removal, a delivery needle cap is pushed toward the syringe to dispense the additive into the cartridge. The delivery needle is then placed within the patient's tissues and the syringe is operated to force the injection mixture from the cartridge. Mixing surfaces on the male body (reservoir plunger) and the female body (reservoir) and other mechanical features homogeneously combine the injection fluid with the additive as the injection mixture travels through the admixing needle during the hypodermic injection. 1. An admixing needle for use with a syringe holding a cartridge containing an injection fluid , comprising:a delivery needle comprising a delivery needle bevel point axially aligned with and in communication with a delivery needle lumen;a cartridge needle comprising a cartridge needle bevel point axially aligned with and in communication with a cartridge needle lumen;a reservoir containing an additive connected in fluid communication between the delivery needle and the cartridge needle with the delivery needle lumen and the cartridge needle lumen coaxially aligned and connected to opposing ends of the reservoir;a delivery needle cap removably placed in a protective position over the delivery needle, coaxially aligned with the delivery needle, and removably connected to the reservoir;a cartridge needle cap removably placed in a protective position over the cartridge needle, coaxially aligned with the cartridge needle, and removably connected to the reservoir;a reservoir ...

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Номер записи: 21
08-03-2018 дата публикации

ADAPTER

Номер: US20180064605A1
Автор: NOGUCHI Yusuke
Принадлежит:

An arm () that faces a male member () is provided with a claw () that protrudes toward the male member (). An adapter () can be connected to a female connector with the male member being inserted into the female connector and the claw engaging with the female connector. The arm is elastically deformable so that the claw can move away from the male member. The claw includes a slidable portion () that slides on the female connector during a process in which the adapter is connected to the female connector. The slidable portion moves the claw in a direction away from the male connector while the slidable portion slides on the female connector. A contour shape of the slidable portion seen in a direction that is orthogonal to a central axis () that passes through the male member includes a smooth convex curve. 1. An adapter comprising: a male member; an arm that faces the male member; and a claw that is provided on the arm so as to protrude toward the male member ,wherein the adapter is configured to be connected to a female connector with the male member being inserted into the female connector and the claw engaging with the female connector,the arm is elastically deformable so that the claw can move away from the male member,the claw includes a slidable portion that slides on the female connector during a process in which the adapter is connected to the female connector,the slidable portion is configured to move the claw away from the male connector while the slidable portion slides on the female connector, anda contour shape of the slidable portion seen in a direction that is orthogonal to a central axis that passes through the male member includes a smooth convex curve.2. The adapter according to claim 1 , wherein the smooth convex curve is an arc or a portion of an ellipse.3. The adapter according to claim 1 , wherein the slidable portion is provided on a rib that extends along a plane that includes the central axis.4. The adapter according to claim 1 , wherein the ...

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Номер записи: 22
08-03-2018 дата публикации

Multiple Dose Vial and Method

Номер: US20180064606A1
Автор: Daniel Py
Принадлежит: Microsoft Technology Licensing LLC

A vial for storing multiple doses of a substance to be dispensed into one or more syringes or other delivery devices. The vial has a body, a storage chamber within the body for storing multiple doses of the substance therein, a sterile filter configured to sterilize air or other gas flowing into the storage chamber through the filter, and a one-way valve connectable in fluid communication with a syringe or other delivery device. The one-way valve is moveable relative to the body between first and second positions (i) one of which permits the valve to open so that substance from the storage chamber can flow therethrough and into the syringe or other delivery device connected in fluid communication therewith, and (ii) one of which prevents the valve from opening.

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Номер записи: 23
15-03-2018 дата публикации

Apparatus and method for aseptically filling pharmaceutical containers with a pharmaceutical fluid using rotary stage

Номер: US20180071168A1
Автор: Craig Rathe, John Senger, Juvenal Naing, Marcin Cichy, Yakov Gofman
Принадлежит: VanRx Pharmasystems Inc, Varnx Pharmasystems Inc

A reconfigurable nest handling system for handling nests of objects arranged in a predetermined pattern is presented and applied to a system for filling nested pharmaceutical containers with a pharmaceutical fluid. In one general aspect, the system comprises a sterilizable chamber containing a planar rotary stage with tub and nest positioning systems that may be reconfigurable for holding differently sized pharmaceutical container tubs and nests and pharmaceutical closure tubs and nests. The chamber has a rotatable cover removal station, a rotatable filling station with a dispenser head, and camera guided vacuum pickup facilities for handling container and closure nests. The vacuum pickup facilities may be reconfigurable for handling differently sized nests. An associated method for filling the containers comprises establishing an aseptic condition within the chamber; removing covers from a container tub and a container closure tub by operating both the rotary stage and the cover removal station. The vacuum pickup facility transfers into the fiducial locating structure a container nest bearing pharmaceutical containers. The fluid is dispensed into the containers by operating both the rotary stage and the filling station. A container closure nest is placed on the container nest in the fiducial locating structure with closures in correspondence with containers. A ram in the chamber forces the closures into the containers.

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Номер записи: 24
24-03-2016 дата публикации

APPARATUS, SYSTEM AND METHOD FOR TRACKING DRUGS DURING A REPACKAGING AND ADMINISTERING PROCESS

Номер: US20160085925A1
Автор: Fedorko Ludwik, Fisher Joseph, Kowalchuk Bryan, Miller Bryan Drew
Принадлежит: UNIVERSITY HEALTH NETWORK

A system for tracking drugs during a transfer and administering process is configured to reduce labeling errors that can occur during that process. The system includes a storage container reader configured to read a set of one or more storage-container-associated machine-readable indicia positioned on a container containing a drug. The set of one or more storage-container-associated machine-readable indicia identifies the drug. The system further includes, at the point of care of a patient, an indicia-generating device configured to generate machine readable drug-delivery-container-associated indicia identifying the drug based on the storage-container-associated machine-readable indicia. A drug delivery container reader, also located at the point of care, is configured to read both sets of machine readable indicia to verify that the drug delivery container has been correctly labelled. A method implemented by the system results in the reduction in labeling errors. 1. A method for tracking drugs during a transfer and administering process , wherein a drug is transferred from a storage container to a drug delivery container , and wherein a container containing a drug is withdrawn from a source of drugs , wherein the container has thereon a set of one or more storage-container-associated machine-readable indicia identifying the drug , the method comprising:a) providing a reader/indicia-generating device including a storage container reader and an indicia-generating device at the point of care of a patient, wherein the storage container reader is configured to read the set of one or more storage-container-associated machine-readable indicia and wherein the indicia-generating device is configured to generate a set of one or more drug-delivery-container-associated indicia identifying the drug, based on the set of one or more storage-container-associated machine-readable indicia;b) causing the storage-container-associated machine-readable indicia to be read by the storage ...

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Номер записи: 25
29-03-2018 дата публикации

MULTI-ENVELOPE BAG AND SYSTEMS AND METHODS FOR DETECTING A POSSIBLE LOSS OF INTEGRITY OF SUCH A BAG

Номер: US20180087997A1
Автор: Hogreve Marc, MENIER Marie-Christine, THENARD Laurent
Принадлежит:

Disclosed is a bag including: a first envelope having at least one fill and/or discharge orifice for a biopharmaceutical fluid and a fill and/or discharge tube associated in a fluidtight manner with the fill and/or discharge orifice, a second envelope within which the first envelope is located, and a spacer element. The first envelope, the second envelope, and the spacer element form a coherent whole, in particular during use of the bag, and the fill and/or discharge tube traverses the second envelope by a fluidtight connection, the fill and/or discharge inlet being located outside the second envelope. 126-. (canceled)28. Bag according to claim 27 , wherein the spacer element is porous and completely covers the wall of the first envelope.29. Bag according to claim 27 , wherein the spacer element is porous and comprises an opening to the wall of the first envelope.30. Bag according to claim 27 , wherein the first envelope is of the 2D type or wherein the first envelope is of the 3D type comprising one or more gussets.31. Bag according to claim 27 , wherein the spacer element comprises at least one porous layer of woven fabric claim 27 , non-woven fabric claim 27 , PE claim 27 , PP claim 27 , or PTFE.32. Bag according to claim 27 , wherein the spacer element is responsive to the biopharmaceutical fluid that reaches it claim 27 , a detection member being provided to detect an interaction between the spacer element and the biopharmaceutical fluid.33. Bag according to claim 27 , wherein the spacer element is neutral to the biopharmaceutical product.34. Bag according to claim 27 , wherein the wall of the second envelope comprises a port suitable for being closed or connected in a fluidtight and removable manner to a source of gas or fluid.35. Bag according to claim 27 , comprising a third envelope which is flexible claim 27 , closed claim 27 , fluidtight claim 27 , and made of plastic claim 27 , having a wall defining a third inner chamber in which the second envelope is ...

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Номер записи: 26
19-03-2020 дата публикации

SYSTEM AND METHOD FOR COMPOUNDING MEDICATION

Номер: US20200085691A1
Автор: MANSOUR George, Quitoviera Neil, Yeh Jonathan, ZOLLINGER Christopher
Принадлежит:

A medication compounding system is described that is capable of receiving one or more medications and diluents and that includes an array of moveable transfer cartridges to access a medication container and to transfer medication. The transferred medication may be joined with a diluent to form a compounded medication. The resulting compounded medication may then be directed to a filling port where a compounded medication container may be coupled. A second medication container may align with a second transfer cartridge to transfer a second medication. Because the device may comprise one or more medications and diluents, a series of compounded medications may be created using an individual transfer cartridge for each medication. 1. A medication compounding system comprising:a medication module rotatable about a first axis of rotation and comprising a medication tray configured to hold one or more medication containers;a transfer module rotatable about a second axis of rotation and configured to hold a circular array of transfer cartridges, and configured to rotate and align a respective transfer cartridge held by the rotatable transfer module with a selected medication container of the one or more medication containers held by the medication tray, the respective transfer cartridge comprising a respective access device configured to couple the respective transfer cartridge with the selected medication container when the respective transfer cartridge is aligned with the selected medication container; andwherein the medication compounding system is configured to, after the respective transfer cartridge and the selected medication container are aligned and coupled, provide for a medication to be withdrawn from the selected medication container to the respective transfer cartridge.2. The medication compounding system of claim 1 , wherein the respective transfer cartridge is coupled with the selected medication container by lowering the medication tray with respect to a ...

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Номер записи: 27
01-04-2021 дата публикации

SYSTEMS AND METHODS FOR DELIVERY OF PERITONEAL DIALYSIS (PD) SOLUTIONS WITH INTEGRATED INTER-CHAMBER DIFFUSER

Номер: US20210093509A1
Автор: Ghatikar Venugopal R., Jensen Lynn E., Jensen Melvin D., Lindley DeLoy
Принадлежит:

The invention provides, in some aspects, a container system for medical solutions such as peritoneal dialysis (PD) solutions. The invention particularly features a system which includes a first compartment that contains a first medical solution, e.g., a PD osmotic agent, and a second compartment that contains a second medical solution, e.g., a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. To that end, a container system can include a diffuser that is disposed in a fluid pathway between the first and second compartments, e.g., to facilitate homogeneous mixing of the first and second PD agents. That diffuser is disposed within and moves relative to a structure, such as a port that defines the fluid pathway between those compartment. Thus, for example, the diffuser can comprise a body that “floats” within that pathway-defining structure and that moves from one end to the other (and/or to from points there between), depending on a direction of solution flow through the structure. 227-. (canceled)28. A container for medical agents , comprising:a compartment having a port,a diffuser that is disposed within the port, moving from a proximal end thereof to a distal end thereof upon expulsion of one or more medical agents from the compartment via the port,wherein the diffuser comprises one or more apertures, each comprising a passage extending any of through a body of and along a surface of the diffuser, to disperse the one or more medical agents upon expulsion via the port,wherein the diffuser is enclosed within the port such that at extremes of its motion within the port, the diffuser does not protrude substantially beyond an end of the port.29. The ...

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Номер записи: 28
01-04-2021 дата публикации

DEVICE AND PROCESS FOR STOPPERING FROM BELOW

Номер: US20210093510A1
Автор: Bauert Dominique, Busimi Anil-Kumar, Kloke Arne
Принадлежит: SCHOTT Schweiz AG

A device is provided that accommodates elongate receptacles and charges. The device includes a superior surface, a first positioning device, a detaining device, and either a pusher or a second positioning device. The first positioning device is adapted and arranged to accommodate a pairing of a charge and a corresponding elongate receptacle. The pusher is moveable along a direction towards the superior surface to introduce the charge into the elongate receptacle. The second positioning device accommodates the pusher with the second positioning device and the pusher being moveable along the direction towards the superior surface to introduce the charge into the elongate receptacle. The detaining device limits the extent of movement of the pusher towards the superior surface. 1. A device for filling a charge into an elongate receptacle , comprising:a superior surface;a first positioning device configured to accommodate the charge and the elongate receptacle; anda detaining device configured to limit an extent of movement of a pusher along a direction towards the superior surface.2. The device of claim 1 , further comprising the pusher claim 1 , wherein the pusher is moveable along the direction towards the superior surface to introduce the charge into the elongate receptacle.3. The device of claim 1 , further comprising a second positioning device configured to accommodate the pusher such that the pusher and the second positioning device are moveable along the direction towards the superior surface.4. The device of claim 3 , further comprising the pusher claim 3 , wherein the pusher is moveable along the direction towards the superior surface to introduce the charge into the elongate receptacle.5. The device of claim 3 , wherein the second positioning device comprises holes in an inferior surface.6. The device of claim 1 , further comprising the charge and the elongate receptacle.7. The device of claim 6 , wherein the charge comprises a thermoplastic elastomer and the ...

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Номер записи: 29
12-05-2022 дата публикации

FLUID TRANSFER DEVICES AND METHODS OF USE

Номер: US20220142865A1
Автор: Janssen Matthias
Принадлежит:

Systems and methods for the transfer of medical fluid are provided. A medical fluid transfer system may comprise a pump configured to transfer fluid through a tube assembly having a first connector configured to couple to a source container and a second connector configured to couple to a target container. The medical fluid transfer system may also comprise a destination sensor configured to output information about the target container. The medical fluid transfer system may further comprise a control system configured to operate the pump based on an operational setting associated with fluid volume; receive measurement data representing a measurement of the target container by the destination sensor, and adjust the operational setting based on an observed volume of fluid transferred to the target container. 1. A medical fluid transfer system comprising:a pump configured to transfer fluid through a tube assembly having a first connector configured to couple to a source container and a second connector configured to couple to a target container;a destination sensor configured to output information about the target container; and receive an instruction to transfer a desired volume of a medical fluid to the target container;', 'operate the pump based on the instruction and an operational setting associated with fluid volume;', 'receive measurement data representing a measurement of the target container by the destination sensor;', 'determine a difference between a transferred volume of the medical fluid and the desired volume of the medical fluid based at least partly on the measurement data and a fluid property of the medical fluid;', 'adjust the operational setting based on the difference; and', 'operate the pump based on the operational setting that has been adjusted., 'a control system configured to2. The medical fluid transfer system of claim 1 , further comprising the tube assembly.3. The medical fluid transfer system of claim 1 , wherein the destination sensor ...

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Номер записи: 30
14-04-2016 дата публикации

DEVICE TO PREPARE AND ADMINISTER TWO-COMPONENT MIXTURE

Номер: US20160100875A1
Автор: FACCIOLI Giovanni, SOFFIATTI Renzo
Принадлежит:

A device to prepare and administer a two-component mixture, including a first chamber in which a container is housed that is hermetically closed for a liquid component, a second chamber containing a powdered component, an opening of the container of the liquid component, a mixing member placed in the second chamber for preparing the mixture and a piston able to move in the second chamber to dispense the mixture. The mixing member includes a stem, passing through an opening for dispensing the mixture in the second chamber, having an outer end equipped with a handle and an inner end provided with a mixing blade connected to the inner end with a releasable connection. 1. A method for preparing and administering a two-component mixture , actuated with a device , wherein the method comprises the following steps:breaking a container of a liquid component;transferring the liquid component from a first chamber to a second chamber;mixing the liquid component and a powdered component through a mixing member, making a mixture;removing a stem of said mixing member; andacting upon a piston to dispense said mixture.2. The method of claim 1 , wherein the container is housed in the first chamber that is hermetically closed for the liquid component.3. The method of claim 1 , wherein the second chamber contains the powdered component and communicates with said first chamber.4. The method of claim 1 , further comprising means for opening said container of the liquid component and wherein the mixing member is associated with said second chamber for preparing the mixture.5. The method of claim 1 , wherein the piston is able to move in said second chamber to dispense the mixture.6. The method of claim 1 , wherein said mixing member comprises means for actuating the mixing member itself claim 1 , said actuation means being able to be actuated from outside of the device claim 1 , said actuation means and said mixing member being associated through releasable connection means.7. The method ...

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Номер записи: 31
26-03-2020 дата публикации

DEVICE FOR SUBCUTANEOUS DELIVERY OF FLUID MEDICAMENT

Номер: US20200093984A1
Автор: Alfandari Shai, BEN DAVID Tamir, GOLOM Dmitry, Grossfeld Rami, LILACH Nir, Mor Tsabar, Nadler Ram, Ozsumer Serdar, Shaki Daniel, Shor Eran, TIKOCHINSKY Yoav
Принадлежит:

An improved device delivers a fluid medicament to the subcutaneous tissue of a user. The device is better suited for patients with Parkinson's Disease and other central nervous system disorders, than conventional infusion devices. The device can include a reusable part including a drive component (e.g., motor) and control electronics and a disposable part including a medicament reservoir. Medicament can be evacuated from the medicament reservoir by a plunger assembly that includes a plunger attached to a lead screw that is rotated by a nut, all within the disposable part. The device can be fluidically coupled with the tissue via a flexible cannula. Various embodiments relate to an improved cannula insertion mechanism that delivers the cannula under a force applied by a spring. Various embodiments relate to improved filling of the device, for example, using a vial adapter and an automated filling station. 1. A device for delivering a fluid medicament into or through the skin of a user , the device comprising: a drive component; and', 'a control unit for controlling the drive component; and, 'a reusable part comprising a first reservoir for containing the fluid medicament, wherein the first reservoir comprises a first bushing;', 'a first plunger head moveable by a first lead screw in the first reservoir; and', 'a first nut concentrically secured by and rotatable in the first bushing, the first nut threadedly engaged with a thread of the first lead screw, wherein when the reusable part and the disposable part are attached, the first nut is operably coupled with and rotatable by the drive component in a direction controllable by the control unit, and wherein the first nut is configured, upon rotation of the first nut in the first bushing, to linearly displace the first lead screw in a direction dependent on a rotation direction of the first nut., 'a disposable part engageable with the reusable part, the disposable part comprising2216.-. (canceled)217. The device of ...

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Номер записи: 32
12-04-2018 дата публикации

Syringe With Connector

Номер: US20180098915A1
Автор: Di Ubaldi John, Rajagopal Sambath Kumar
Принадлежит:

A syringe comprising a syringe barrel having a distal end, a distal tip, an open proximal end, a barrel sidewall extending between the distal end to the open proximal end and defining a chamber, the barrel sidewall having a barrel sidewall thickness t, the distal end of the syringe barrel including a distal wall is disclosed. The syringe includes a connector integrally formed with and extending distally from the syringe barrel at the distal wall, the connector including a collar disposed coaxially around an elongate tip in fluid communication with the barrel to form a channel between the elongate tip and the collar, the collar including an inside surface, an outside surface and a plurality of ribs extending radially outwardly from the outside surface and separated by spaces, each of the plurality of ribs having a height H and a width W, wherein there is a ratio of the height H to the barrel sidewall thickness tin a range of 0.75 and 1. 1. A syringe comprising:a syringe barrel having a distal end, a distal tip, an open proximal end, a barrel sidewall extending between the distal end to the open proximal end and defining a chamber, the barrel sidewall having a barrel sidewall thickness t, the distal end of the syringe barrel including a distal wall; anda connector integrally formed with and extending distally from the syringe barrel at the distal wall, the connector including a collar disposed coaxially around an elongate tip in fluid communication with the barrel to form a channel between the elongate tip and the collar, the collar including an inside surface, an outside surface and a plurality of ribs extending radially outwardly from the outside surface and separated by spaces, each of the plurality of ribs having a height H and a width W, wherein there is a ratio of height H to barrel sidewall thickness t in a range of 0.75 and 1.2. The syringe of claim 1 , wherein each of the plurality of ribs has at least one of a taper and a curve extending in a distal ...

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Номер записи: 33
21-04-2016 дата публикации

Mixing System for Mixing Biological Specimens with Additives

Номер: US20160106624A1
Автор: CAMISANI Julien Pierre, Waridel Olivier
Принадлежит: BIOSAFE S.A.

A device for mixing biological specimens contained in flexible storage bags () at controlled temperature, comprising a support () for supporting a storage bag containing a biological specimen to be mixed; means for imparting a displacement to a specimen in a storage bag on the support to mix the specimen; and temperature control means for maintaining the specimens at a controlled temperature during mixing. The means for imparting displacement to a specimen comprises at least one inflatable/deflatable bag () (air bag) that when inflated contacts the surface of a part of a storage bag to progressively squeeze the storage bag and displace the contained specimen into another part of the storage bag. 2. The device according to claim 1 , wherein the airbag is located under a cover that fits over the support.3. The device according to claim 2 , wherein the cover is pivotally mounted on the support claim 2 , and comprising means for locking the cover in a closed position on the support to prevent the cover from opening as a result of inflation of the air bag during mixing.4. The device according to claim 2 , or which further comprises means for supplying an additive to the biological specimen in a storage bag placed on the support claim 2 , before and/or during mixing.5. The device according to any preceding claim claim 2 , further comprising a lip that projects from the cover and/or from the support for constricting a storage bag on the support.6. The device according to claim 5 , comprising at least one removable lip that can be removably fixed on the cover and/or on the support.7. The device according to or claim 5 , wherein the support is configured to receive one large bag or two small bags claim 5 , the support and/or the cover having a lip that constricts a middle part of the large bag when fitted and on either side of which the small bags can be fitted.8. The device according to any preceding claims claim 5 , wherein the temperature control means comprises at least ...

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Номер записи: 34
29-04-2021 дата публикации

SYSTEM AND METHOD FOR SAFETY SYRINGE

Номер: US20210121640A1
Автор: DIAZ Stephen H., Merhige John, SHANLEY John F., Shluzas Alan E., STEESE-BRADLEY Gary, Thayer Dan, Tillack Jeff
Принадлежит: Credence Medsystems, Inc.

A system for mixing drug products and injecting includes a syringe body, proximal and distal stopper members disposed in the syringe body, a plunger member, and a needle hub assembly coupled to the distal needle interface of the syringe body. The proximal and distal stopper members form a proximal drug chamber between there between and a distal drug chamber between the distal stopper member and a distal end of the syringe body. The plunger member includes a needle retention feature, an energy-storage member, and an energy-storage member latching member all disposed in disposed in a plunger interior. First and second sizes of the respective proximal and distal drug chambers can be modified by movement of the proximal and distal stopper members relative to the syringe body. The needle is at least partially retractable into plunger interior upon manipulation of the plunger member relative to the syringe body. 1. A system for mixing drug products and injecting , comprising:a cylindrical injection body defining a proximal opening and a distal needle interface at a distal end thereof;proximal and distal stopper members disposed in the cylindrical injection body, forming a proximal drug chamber between the proximal and distal stopper members and a distal drug chamber between the distal stopper member and the distal end of the cylindrical injection body; a needle retention feature disposed in the plunger interior,', 'an energy-storage member disposed in the plunger interior, and', 'an energy-storage member latching member disposed in the plunger interior; and, 'a plunger member defining a plunger interior and configured to insert the proximal stopper member relative to the cylindrical injection body, the plunger member including'} a needle having a needle proximal end feature,', 'a hub, and', 'a needle latching member configured to couple the needle to the hub,, 'a needle hub assembly coupled to the distal needle interface of the cylindrical injection body, the needle hub ...

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Номер записи: 35
10-07-2014 дата публикации

Fluid Exchange Methods and Devices

Номер: US20140193381A1
Автор: Brian David Warner, John Dunne
Принадлежит: Becton Dickinson and Co

Methods and devices for exchanging therapeutic agents, such as cells, from one liquid medium to another liquid medium are provided. Aspects of embodiments of the methods include transferring a therapeutic agent from a first medium, such as a freezing, storage or shipping buffer, into a second medium, such as a sterile physiologically compatible buffer. In certain aspects, the transfer of the therapeutic agent from a first medium to a second medium involves the use of acoustic-focusing, or acoustophoresis. Embodiments of the subject methods may facilitate the transfer of a therapeutic agent from a storage medium to an infusion medium, and in certain embodiments include administering the therapeutic agent contained in the infusion medium to the subject. Also provided by the present disclosure are devices for practicing the subject methods.

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Номер записи: 36
26-04-2018 дата публикации

Pressurized Gas Powered Medicament Transfer And Re-Suspension Apparatus And Method

Номер: US20180110922A1
Автор: Dunki-Jacobs Adam, Hooven Michael D., HUDDLESTON Matthew J., Nuchols Richard P., Palmer Joetta Renee, Stefanchik David
Принадлежит:

Apparatus and method are described employing pressurized gas to transfer, mix and/or reconstitute medicament contained in a vial and flowing it into an injection device. Pressurized gas may be provided by prefilled cartridge. 121.-. (canceled)22. A medicament Medicament transfer apparatus for transferring fluid from a fluid-containing vial to an injection device , comprising:a pressurized gas source comprising a pre-filled pressure vessel including a puncturable seal,{'sub': '.', 'at least one vial receiving station, and a medication injection device receiving station, a gas flow path communicable between the gas source and the vial receiving station and a fluid flow path communicable between the vial receiving station and the medication injection device receiving station,'}a puncturing pin for puncturing the seal, andan actuator for moving the puncturing pin and/or the vessel between a pre-puncture position and a puncture position.2326.-. (canceled)27. The medicament transfer apparatus of in which the actuator comprises a stored energy source biased to move the puncturing pin and/or the vessel to the puncture position.28. The medicament transfer apparatus of in which the stored energy device comprises a spring.2943.-. (canceled)44. A re-suspension device for re-suspending medicament contents of a vial of the type having an open end sealed by a septum claim 27 , the re-suspension device comprising:a housing including;a diluent port;a gas port;a vent port;a vial receiving station;a first spike lumen and a second spike lumen extending from the vial receiving station for piercing a vial septum when a vial is received at the vial receiving station;a gas flow path communicating between the gas entry port and the first spike lumen;a diluent flow path communicating between the diluent port and the first spike lumen;a vent flow path communicating between the vent port and the second spike lumen; anda hydrophobic filter cooperatively associated with the vent flow path for ...

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Номер записи: 37
26-04-2018 дата публикации

Method for preparing liquid medium composition, and preparation device and kit therefor

Номер: US20180112013A1
Автор: Hisato Hayashi, Koichiro Saruhashi, Tatsuro Kanaki
Принадлежит: Nissan Chemical Corp

The present invention provides a method capable of easily mixing any liquid containing a linking substance such as a divalent metal cation and the like with a liquid containing a particular compound at a high concentration, and capable of producing a liquid medium composition comprising fine structures dispersed therein, and a production device therefor and a kit therefor. The first liquid containing a particular compound is passed through a through-hole having a given cross-sectional area formed in a nozzle part at a given flow rate and injected into the second liquid at a given flow rate. By this simple operation, a structure in which the particular compound is bonded via the linking substance is formed, and the structure is preferably dispersed in a mixture of the both liquids.

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Номер записи: 38
13-05-2021 дата публикации

Methods and compositions for formulating and dispensing pharmaceutical formulations

Номер: US20210139834A1
Автор: Dorina ROBERMAN, Lior Raviv, Nadav ESHKOL
Принадлежит: Pluristem Ltd

The present disclosure relates to use of specialized vessels for formulating and dispensing pharmaceutical formulations. The vessels are optionally able to maintain homeostatic conditions and a homogeneous constitution of pharmaceutical suspensions, while simultaneously dispensing them into single-use containers.

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Номер записи: 39
25-08-2022 дата публикации

Dosing and administration system for drug combinations

Номер: US20220265516A1
Автор: Marieke GOSAU, Rolf MÜHLEMANN, Sonja SCHERTEL
Принадлежит: HERMES ARZNEIMITTEL GMBH, Hermes Pharma GmbH, Muehlemann Ip Gmbh

The present invention provides a cartridge for the preparation of a liquid pharmaceutical or nutraceutical formulation, the cartridge being adapted for insertion into a mixing vessel and for dispensing at least three flowable pharmaceutical or nutraceutical compositions into said mixing vessel, the cartridge comprising a container portion, a cover portion and an opening means, or more specifically an opening means of the container portion, for opening the cartridge, preferably after its insertion into the mixing vessel, wherein the container portion comprises a container wall and a container base, the container wall and the container base defining an inner lumen and an opening of the container portion, the opening being positioned opposite to the container base, and a segmenting structure located in the inner lumen of the container portion and being physically connected to the container wall and/or to the container base such as to divide the inner lumen of the container portion into at least three segments containing the at least three flowable pharmaceutical or nutraceutical compositions.

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Номер записи: 40
25-04-2019 дата публикации

DEVICES AND SYSTEMS WITH AN EXTERNAL DISPLACEMENT MECHANISM FOR CONTAMINANT-FREE ENGAGEMENT OF PHARMACEUTICAL VESSELS AND PHARMACEUTICAL ADMINISTRATION DEVICES

Номер: US20190117513A1
Автор: Naygauz Mikael
Принадлежит:

The present invention relates, in some embodiments thereof, to systems, devices and methods allowing for an engagement of two or more vessels or devices in a decontaminated manner. In some embodiments of the invention, the systems and devices of the invention include a first connection interface attached to a first vessel having a spring and/or valve mechanism and a second connection interface attached to a second vessel, wherein the first connection interface and the second connection interface are configured to allow for an engagement between the first vessel and the second vessel, and wherein the first and second connection interfaces are further configured to externally displace from the engagement between the first vessel and the second vessel while a hermetically sealed connection is maintained between the first vessel and the second vessel. 1. A system for contaminant-free engagement of vessels , comprising:a first vessel having a first connection interface and a sealing mechanism, the first connection interface configured to externally displace from the first vessel, the sealing mechanism configured to seal an aperture through which the first connection interface moves through during external displacement of the first connection interface;a second vessel having a second connection interface, the second connection interface configured to externally displace from the second vessel.2. The system of claim 1 , wherein the sealing mechanism is a spring mechanism.3. The system of claim 1 , wherein the sealing mechanism is a valve mechanism.4. The system of claim 1 , wherein the sealing mechanism is disposed within the aperture claim 1 , the sealing mechanism is configured to apply pressure in an outward direction against an inner wall of the first connection interface claim 1 , thereby sealing the aperture.5. The system of claim 4 , wherein the sealing mechanism is a spring mechanism.6. The system of claim 4 , wherein the sealing mechanism is a valve mechanism.7. ...

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Номер записи: 41
16-04-2020 дата публикации

MULTI-MIX INFUSION BAG

Номер: US20200113782A1
Автор: Caquias Jesus A., Caquias Tomas A.
Принадлежит:

A multi-mix infusion bag is provided. The multi-mix infusion bag includes a lower portion and an upper portion. The lower portion has a lower chamber and the upper portion includes a plurality of chambers. Each chamber is separated and contains a fluid agent. The multi-mix infusion bag is configured to transfer each fluid agent within each chamber of the upper portion into the lower chamber for mixing. The multi-mix infusion bag may include dispensing devices associated with each chamber, wherein the dispensing devices operate to transfer the fluid agents into the lower chamber for mixing. 1. A multi-mix infusion bag comprising:a lower portion having a lower chamber;an upper portion comprising a plurality of chambers, wherein each chamber is separated and contains a fluid agent;a separating wall located between the upper portion and the lower portion to prevent the fluid agents in the plurality of chambers from entering the lower chamber; anda plurality of perforations formed the separating wall, the plurality of perforations corresponding to the plurality of chambers, wherein each perforation is formed in response to pressure applied to each of the plurality of chambers of the upper portion, wherein the fluid agent from each of the plurality of chambers is transferred into the lower chamber through the perforations for mixing of the fluid agents.2. The bag of claim 1 , further comprising an outlet coupled to the lower chamber claim 1 , wherein the mixed fluid agents are dispensed through the outlet.3. The bag of claim 2 , further comprising an inlet coupled to the lower chamber.4. The bag of claim 3 , wherein an additive is flowed into the lower chamber through the inlet and mixed with the fluid agents in the lower chamber. This application is a Continuation of U.S. patent application entitled “MULTI-MIX INFUSION BAG,” Ser. No. 14/804,071, filed Jul. 20, 2015 which claims priority to U.S. Provisional patent application entitled “MULTI-MIX INFUSION BAG,” Ser. No. 62 ...

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Номер записи: 42
25-08-2022 дата публикации

Method for preparing liquid medium composition, and preparation device and kit therefor

Номер: US20220267480A1
Автор: Hisato Hayashi, Koichiro Saruhashi, Tatsuro Kanaki
Принадлежит: Nissan Chemical Corp

The present invention provides a method capable of easily mixing any liquid containing a linking substance such as a divalent metal cation and the like with a liquid containing a particular compound at a high concentration, and capable of producing a liquid medium composition comprising fine structures dispersed therein, and a production device therefor and a kit therefor. The first liquid containing a particular compound is passed through a through-hole having a given cross-sectional area formed in a nozzle part at a given flow rate and injected into the second liquid at a given flow rate. By this simple operation, a structure in which the particular compound is bonded via the linking substance is formed, and the structure is preferably dispersed in a mixture of the both liquids.

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Номер записи: 43
19-05-2016 дата публикации

EVACUATED BOTTLE SYSTEM

Номер: US20160136048A1
Автор: HUBBARD JOSHUA W., MARANTIS MICHAEL G., PONTON RICHARD A., RICHARDS JONATHAN P.
Принадлежит:

An evacuated bottle system including a bottle defining a hollow interior, the bottle having a neck with a rim defining an opening; a cap assembly supported on the bottle, the cap assembly including a funnel having a first portion and a second portion, the first portion being insertable within the interior of the bottle and the second portion engaging a portion of the bottle to support the funnel above the rim, the funnel defining a bore that fluidly communicates with the hollow interior of the bottle; a self-sealing membrane that covers the bore formed by the funnel to selectively seal the hollow interior of the bottle; a cap attachable to the bottle, the cap including a cover portion that extends at least partially over the self-sealing membrane to restrain movement thereof, the cover portion being axially spaced from the self-sealing membrane to define a gap that permits axial movement of the self-sealing membrane to selectively open the bottle to fluid communication outside of the bottle. 1. An evacuated bottle system comprising:a bottle defining a hollow interior, the bottle having a neck with a rim defining an opening;a cap assembly supported on the bottle, the cap assembly including a funnel having a first portion and a second portion, the first portion being insertable within the interior of the bottle and the second portion engaging a portion of the bottle to support the funnel above the rim, the funnel defining a bore that fluidly communicates with the hollow interior of the bottle; a self-sealing membrane that covers the bore formed by the funnel to selectively seal the hollow interior of the bottle; a cap attachable to the bottle, the cap including a cover portion that extends at least partially over the self-sealing membrane, the cover portion being axially spaced from the self-sealing membrane to define a gap that permits axial movement of the self-sealing membrane to selectively open the bottle to fluid communication outside of the bottle.2. The system ...

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Номер записи: 44
08-09-2022 дата публикации

MEDICAL FLUID INJECTION AND TRANSFER DEVICES AND METHOD

Номер: US20220280385A1
Автор: Converse Rowan Joseph, Geiger Daniel L., HUDDLESTON Matthew J., Lowe James, Nuchols Richard P., Stefanchik David
Принадлежит:

A medical fluid injection device, a medical fluid transfer device and a method of administering and transferring a medical fluid are disclosed. The device and method may include a compressed gas canister in fluid communication with an expandable elastic bladder positioned within a vial of drug to provide a means to deliver drug through an injection cannula that is movable between a plurality of positions or through a transfer conduit. 1. An injection device comprising:a. a vial holder configured to hold a vial containing a medical fluid;b. a canister holder configured to hold a compressed gas canister;c. a balloon;d. a balloon spike in fluid communication with the balloon and configured to be inserted into a vial positioned in the vial holder and to selectively communicate with a compressed gas canister positioned within the canister holder so that the balloon is inflated within the vial to pressurize medical fluid within the vial;e. an injection spike configured to be inserted into a vial positioned in the vial holder;f. an injection cannula selectively in fluid communication with the injection spike so that medical fluid pressurized in the vial by inflation of the balloon flows through the injection cannula.2. The injection device of wherein the balloon is configured to be positioned within a lumen of the balloon spike during insertion into the vial.3. The injection device of further comprising a vial containing a liquid drug positioned within the vial holder.4. The injection device of further comprising a compressed gas canister positioned within the canister holder.5. The injection device of further comprising a vial containing a medical fluid positioned within the vial holder and a compressed gas canister positioned within the canister holder.6. The injection device of wherein the vial includes a vial stopper which is pierced by the balloon spike and the injection spike as they are inserted into the vial.7. The injection device of wherein the balloon spike and ...

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Номер записи: 45
15-09-2022 дата публикации

SYSTEM AND METHODS FOR TREATING CANCER CELLS WITH ALTERNATING POLARITY MAGNETIC FIELDS

Номер: US20220288407A1
Автор: Sharma Vivek K.
Принадлежит: Asha Medical, Inc.

Systems and methods for destroying or inhibiting cancer cells and other rapidly-dividing cells include coupling an alternating polarity (AP) magnetic field generator to a target body area and applying an AP magnetic field having a frequency of 0.5-500 kHz and a field strength of 0.5-5 mT to the target body area to achieve a desired inhibiting effect on cancer cells or other rapidly-dividing cells. Treatments provided by the system may be co-administered with an anti-cancer drug such as a chemotherapy drug, a hormone therapy drug, targeted therapy drugs, immunotherapy drugs, or an angiogenesis inhibitor drug. 1. A method of treating cancer cells in a target body area of a patient , comprising: an alternating polarity (AP) magnetic field generator;', 'one or more AP electromagnetic coils coupled to the AP magnetic field generator, wherein the one or more AP electromagnetic coils are energized by an electrical signal from the AP magnetic field generator to generate an AP magnetic field having at least a first frequency and a first field strength; and', 'a controller to control at least one of the first frequency and the first field strength of the AP magnetic field generated by the one or more AP electromagnetic coils;, 'using a magnetic field therapy system comprisingcoupling the one or more AP electromagnetic coils to the target body area;generating an AP magnetic field having a first frequency of 0.5-500 kHz and a first field strength of 0.2-5 mT using the one or more AP electromagnetic coils;applying the generated AP magnetic field to the target body area using the one or more AP electromagnetic coils, wherein the AP magnetic field selectively affects the cancer cells to prevent metastasis of the cancer cells, while leaving non-cancer cells substantially unharmed.2. The method of claim 1 , wherein coupling the one or more AP electromagnetic coils to the target body area comprises using a retaining element to maintain the one or more AP electromagnetic coils in ...

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Номер записи: 46
31-05-2018 дата публикации

COMPOUNDING SYSTEMS AND METHODS FOR SAFE MEDICAMENT TRANSPORT

Номер: US20180147118A1
Автор: Garfield Jared, Lyon Gregory
Принадлежит: J&J SOLUTIONS, INC. d/b/a Corvida Medical

An automatic or semi-automatic preparation system and process is provided for forming a medicament solution from a vial containing one of a liquid and a non-liquid material. 1. An automatic or semi-automatic preparation system for forming a medicament solution from a vial containing one of a liquid and a non-liquid material , the preparation system comprising: at least one first rail defining a first axis;', 'at least one second rail defining a second axis, the second axis being oriented orthogonal to the first axis;', 'at least one third rail defining a third axis, the third axis being oriented orthogonal to the each of the first axis and the second axis;', 'a first gear belt movably supported on at least one of the first rails, the second rails or the third rails, wherein the first gear belt, the first gear belt is movably supported on a series of sprockets; and', 'a second gear belt movably supported on at least one of the first rails, the second rails or the third rails, wherein the second gear belt, the first gear belt is movably supported on a series of sprockets; the first gear belt and the second gear belt being spaced apart from one another and being arranged in parallel with one another., 'a carousel configured to provide three axes of motion, the carousel including a manipulator having2. The preparation system according to claim 1 , wherein the carousel further comprises:at least one component holder supported on at least one of the first gearbelt and the second gear belt, each component holder being configured to selectively hold a syringe, a vial, a syringe adapter or a vial adapter; andat least one of a rotation station, a transfer station, and a weigh station disposed about the carousel;wherein the rotation station is configured for inverting and reverting a syringe and vial assembly;wherein the transfer station is configured for transferring material from a vial to a syringe; andwherein the weigh station is configured for weighing at least one of the ...

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Номер записи: 47
01-06-2017 дата публикации

DEVICE AND METHOD FOR DOCKING A VIAL WITH A CONTAINER

Номер: US20170151128A1
Автор: CLOUSER Doug, Sharpe Gary L.
Принадлежит:

A device and method for docking a vial with a container adapter is disclosed. An adapter may be used to establish fluid communication between the vial and a container. The adapter may be positioned within an aperture in a platform of the device. A notch may be placed adjacent to the first aperture so that the vial and adapter may be removed horizontally from the device. A cavity may be positioned below the first aperture to accept at least a portion of a container which may be in fluid communication with the adapter. The platform may be removable, contain multiple apertures, or may be configured to receive various adapter types. 1. A device for docking a vial with an adapter comprising:a base;a vertical support extending upwardly from the base;a platform positioned above the base;a first aperture in the platform sized to accept the adapter;a head support extending from the vertical support;a lever arm hingedly fastened to the vertical support; anda plunger adapted to slide within the head support and attached to the lever arm such that rotation of the lever arm causes the plunger to travel vertically.2. The device of wherein:the bottom of the plunger has a conical recess.3. The device of wherein:a centerline of the first aperture is substantially aligned with a centerline of the conical recess.4. The device of further comprising:a collar attached to the plunger which limits the upward vertical movement of the plunger.5. The device of wherein:the platform is removable.6. The device of wherein:the first aperture comprises a guide channel extending from the top of the platform to the bottom.7. The device of wherein:the first aperture comprises at least two concentric apertures having a common center-line, different diameters, and different depths.8. The device of wherein:the first aperture has an opening along one side of the platform.9. The device of wherein:the platform has a second aperture arranged opposite the first aperture.10. The device of wherein:the first and ...

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Номер записи: 48
07-06-2018 дата публикации

Connection assembly for conducting a medical liquid

Номер: US20180153770A1
Автор: Torsten Brandenburg
Принадлежит: FRESENIUS KABI DEUTSCHLAND GmbH

A connection assembly for conducting a medical liquid, comprising a connection piece, an attachment part attached to the connection piece; an opening into which the connection piece engages; and a seal element for sealing a passage between the connection piece and the attachment part. The seal element is held between the attachment part and the connection piece and has a sealing head, which closes the opening of the attachment part against the passage of liquid when the attachment part is attached to the connection piece, and a body, which adjoins the sealing head and which can be arranged in the opening at a radial distance to the attachment part.

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Номер записи: 49
23-05-2019 дата публикации

SEALER-LESS PLASMA BOTTLE AND TOP FOR SAME

Номер: US20190151200A1
Автор: McDowell Christopher S.
Принадлежит: Haemonetics Corporation

A top for a plasma storage container includes a top body that defines the structure of the top and seals an opening of the plasma storage container. The top also includes a first opening and a vent opening extending through the top body. A septum is located at least partially within the first opening and includes an aperture therethrough. The septum allows a blunt cannula to pass through the aperture to access the interior of the plasma storage container. The top also includes a hydrophobic membrane located on underside of the top body. The membrane covers the vent opening and allows air to vent through the vent opening during plasma collection. 1. A top for a plasma storage container comprising:a top body defining the structure of the top and configured to seal an opening of the plasma storage container;a first opening extending through the top body;a septum located at least partially within the first opening, the septum including an aperture therethrough and configured to allow a blunt cannula to pass through the aperture to access the interior of the plasma storage container;a vent opening extending through the top body; anda hydrophobic membrane located on underside of the top body and covering the vent opening, the hydrophobic membrane configured to allow air to vent through the vent opening during filling of the plasma storage container.2. A top for a plasma storage container according to claim 1 , further comprising:a skirt extending from the underside of the top body around the first opening, the septum located and secured within the skirt.3. A top for a plasma storage container according to claim 2 , wherein the septum is secured within the skirt via swage connection.4. A top for a plasma storage container according to claim 3 , wherein the skirt and/or the swage connection applies a radially inward force on the septum claim 3 , the radially inward force keeping the septum secured within the skirt.5. A top for a plasma storage container according to claim 1 ...

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Номер записи: 50
07-06-2018 дата публикации

Fill and finish systems and methods

Номер: US20180155070A1
Автор: Alexandra Salomon, Christopher J. Wegener, Julie Griep, Kyungyoon Min
Принадлежит: Fenwal Inc

A variety of fill options is provided for a cell processing system. Certain options relate to a filling system associated with the cell processing system, the filling system comprising one or more filling stations, each with at least one container that may receive product from a container associated with a cell processing system. Other options relate to a syringe assembly that receives a product from a container associated with a cell processing system.

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Номер записи: 51
08-06-2017 дата публикации

Method and apparatus for applying a topical solution

Номер: US20170157379A1
Автор: Mark Carota, Thomas Boyajian
Принадлежит: Dusa Pharmaceuticals Inc

An applicator for dispensing a solution having two or more components includes a hollow body having a head provided at one end of the hollow body for dispersion of the solution and a breaking mechanism attached to the hollow body. The breaking mechanism includes at least one projection extendable into an interior of the hollow body. The applicator further includes a plurality of ampoules placed in the interior of the hollow body. The plurality of ampoules contains the two or more components. Upon activation of the breaking mechanism, the at least one projection applies a force to the plurality of ampoules such that the plurality of ampoules break and release the two or more components to form the solution.

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Номер записи: 52
30-05-2019 дата публикации

SYRINGE ACCESSORY FOR TRANSFER OF AIR SENSITIVE MATERIALS

Номер: US20190159969A1
Автор: Kobilka Brandon M., Kuczynski Joseph, PORTER Jacob T., Wertz Jason T.
Принадлежит:

An apparatus, method, and article of manufacture for transferring fluid contained in a syringe. The apparatus includes an airlock component having a cylindrical body with a first end, a second end, and a hollow tube disposed between the first end and the second end. An annular opening is located at the first end of the cylindrical body. The hollow tube includes a gas inlet aperture and a gas outlet aperture. The hollow tube also includes an inwardly-facing airtight material coupled to the interior surface of the hollow tube, and a septum coupled to the second end of the cylindrical body. The method includes transferring fluid from one container to a second container using the apparatus. The article of manufacture includes the apparatus, a syringe, and a needle. 1. An apparatus for transferring fluid contained in a syringe , comprising:an airlock component having a cylindrical body, the cylindrical body having a first end, a second end, and a hollow tube disposed between the first end and the second end, wherein the hollow tube has an interior surface and an exterior surface;an annular opening at the first end of the cylindrical body;a gas inlet aperture from the exterior surface of the hollow tube to the interior surface of hollow tube;a gas outlet aperture from the interior surface of the hollow tube to the exterior surface of the hollow tube;an inwardly-facing airtight material coupled to the interior surface of the hollow tube; anda septum coupled to the second end of the cylindrical body.2. The apparatus of claim 1 , further comprising an attachment member having a first end coupled to the second end of the cylindrical body claim 1 , and a second end having elongate legs that form an annular body around an exterior surface of a container.3. The apparatus of claim 1 , wherein the inwardly-facing material is an O-ring.4. The apparatus of claim 1 , wherein the inwardly-facing material is a hollow plug.5. The apparatus of claim 1 , wherein the septum is a silicone ...

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Номер записи: 53
23-06-2016 дата публикации

Fluid Exchange Methods and Devices

Номер: US20160175198A1
Автор: Dunne John, Warner Brian David
Принадлежит:

Methods and devices for exchanging therapeutic agents, such as cells, from one liquid medium to another liquid medium are provided. Aspects of embodiments of the methods include transferring a therapeutic agent from a first medium, such as a freezing, storage or shipping buffer, into a second medium, such as a sterile physiologically compatible buffer. In certain aspects, the transfer of the therapeutic agent from a first medium to a second medium involves the use of acoustic-focusing, or acoustophoresis. Embodiments of the subject methods may facilitate the transfer of a therapeutic agent from a storage medium to an infusion medium, and in certain embodiments include administering the therapeutic agent contained in the infusion medium to the subject. Also provided by the present disclosure are devices for practicing the subject methods. 18-. (canceled)9. A device for transferring a therapeutic agent , the device comprising:a first container providing the therapeutic agent suspended in a first medium; 'an acoustophoresis device in fluidic communication with the first and second containers and configured to exchange the second medium for the first medium, to produce the therapeutic agent suspended in the second medium.', 'a second container providing a second medium;'}10. The device according to claim 9 , further comprising a channel in fluidic communication with the acoustophoresis device and configured to receive the therapeutic agent suspended in the second medium and administer the therapeutic agent suspended in the second medium to a patient.11. The device according to claim 10 , comprising at least one pump to control a flow rate of the first medium or the second medium through the acoustophoresis device.12. The device according to claim 10 , wherein the acoustophoresis device comprises 2 or more separation channels.13. The device according to claim 10 , wherein the device is sterile.14. A kit comprising:an acoustophoresis device configured to connect with two ...

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Номер записи: 54
21-06-2018 дата публикации

ANTIBODY FORMULATION

Номер: US20180171004A1
Автор: CROMWELL Mary, GOKARN Yatin R., KAMERZELL Timothy J., LI Megan, Liu Hong
Принадлежит:

The invention provides a stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody, optionally, not subjected to prior lyophilization, a buffer maintaining the pH in the range from about 4.0 to about 6.0, and an optional surfactant, methods for making such a formulation, and methods of using such a formulation. 156-. (canceled)57. A method of treating a disease or disorder in a subject comprising administering an effective amount of a pharmaceutical formulation to the subject , wherein the pharmaceutical formulation comprises an antibody that binds to VEGF in an arginine acetate buffer at a pH from about 4.5 to about 6.0 , and a surfactant , wherein the antibody is bevacizumab.5870-. (canceled)71. The method of claim 57 , wherein the disease or disorder is cancer.72. The method of claim 71 , wherein the cancer is colorectal cancer claim 71 , lung cancer claim 71 , breast cancer claim 71 , renal cancer claim 71 , or glioblastoma.73. The method of claim 57 , wherein the arginine acetate buffer is at a pH from about 4.5 to about 5.5.74. The method of claim 57 , wherein the arginine acetate buffer is at a pH from about 4.8 to about 5.4.75. The method of claim 57 , wherein the arginine acetate buffer is at pH about 5.2.76. The method of claim 57 , wherein the arginine acetate concentration in the buffer is from about 25 mM to about 250 mM.77. The method of claim 57 , wherein the arginine acetate concentration in the buffer is from about 50 mM to about 250 mM.78. The method of claim 57 , wherein the arginine acetate concentration in the buffer is from about 75 mM to about 250 mM.79. The method of claim 57 , wherein the arginine acetate concentration in the buffer is from about 100 mM to about 250 mM.80. The method of claim 57 , wherein the arginine acetate concentration in the buffer is from about 120 mM to about 240 mM.81. The method of claim 57 , wherein the arginine acetate concentration in the buffer is from about 150 mM to ...

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Номер записи: 55
22-06-2017 дата публикации

MEDICINE DISPENSING SYSTEM

Номер: US20170177830A1
Автор: Kreiner Barrett M., Reeves Jonathan L.
Принадлежит:

Devices, methods, and computer-readable media are disclosed for storing and neutralizing a medicine. For example, a device may include a chamber for storing a medicine, a neutralizing component coupled to the chamber, a transceiver for receiving an instruction to neutralize the medicine, and a control unit that includes a processor and that is coupled to the transceiver, where the control unit is for neutralizing the medicine by activating the neutralizing component when the instruction is received via the transceiver. In another example, a device may include a medicine chamber for storing a medicine, an intermediate chamber for storing a neutralizing agent to neutralize the medicine, where a first wall between the medicine chamber and the intermediate chamber comprises a fluid-soluble material, and an outer chamber for storing a fluid, where the intermediate chamber and the outer chamber share a second wall. 1. A storage device comprising:a chamber configured to store a medicine;a neutralizing component coupled to the chamber;a transceiver configured to receive an instruction to neutralize the medicine; anda control unit comprising a processor, wherein the control unit is coupled to the transceiver, wherein the control unit is configured to neutralize the medicine by activating the neutralizing component when the instruction is received via the transceiver, and wherein the control unit is also configured to neutralize the medicine by activating the neutralizing component when a time has expired according to a medicine administering plan stored by the control unit.2. The storage device of claim 1 , wherein the control unit is further configured to transmit usage information associated with the medicine via the transceiver.3. (canceled)4. The storage device of claim 1 , further comprising:a tamper detection unit configured to detect a tampering of the storage device, wherein the control unit is for neutralizing the medicine when the tampering of the storage device is ...

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Номер записи: 56
13-06-2019 дата публикации

SAFETY FLUID DISPENSER

Номер: US20190175449A1
Автор: Atkins, Atkins Lori Jean, Jr. James H.
Принадлежит:

An apparatus that includes a container portion and a coupler portion. The container and coupler are, in one embodiment, mated via an adapter that includes a one-way valve. The coupler includes a second one-way valve. In use, a fluid source, such as a vial, is connected to the coupler. An air source, such as a syringe is also connected to the coupler. Air from the syringe is introduced to the vial via the second one-way valve. The second one-way valve prevents fluid from the vial from being drawn into the syringe. Introduction of air from the syringe into the vial forces fluid from the vial into the container via the first one-way valve. The first one-way valve prevents the fluid from escaping the container. 1. (canceled)2. A method comprising: 'the coupler is attached to a container; and', 'attaching a fluid source to a coupler, wherein'} [ 'introducing another fluid into the fluid source via a first valve, and', 'the dispensing comprises'}, 'the another fluid forces the fluid through a second valve into the container., 'dispensing fluid from the fluid source into the container via the coupler, wherein'}3. The method of claim 2 , wherein air, or', 'a sterile saline solution., 'the another fluid comprises at least one of'}4. The method of claim 2 , wherein the container comprises an adapter claim 2 , and the method further comprises: 'the attaching the coupler to the adapter attaches the coupler to the container via the adapter.', 'attaching the coupler to the adapter, wherein'}5. The method of claim 4 , whereinthe first valve is configured to prevent the fluid from traversing the first valve,the coupler is configured to transfer the fluid from the fluid source into the container via the second valve, and admit the fluid from the coupler into the container at the adapter, and', 'prevent fluid flow from the container into the coupler at the adapter., 'the second valve is configured to'}6. The method of claim 2 , wherein the another fluid is air claim 2 , and the ...

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Номер записи: 57
06-07-2017 дата публикации

FILLING ASSIST MECHANISMS AND KEYED INTERFACES FOR DRUG DELIVERY DEVICES

Номер: US20170189270A1
Автор: Allis Daniel P., BARLETTA Steven, Choate Bryan, Clare David, Dillon Bryan, DOBRY Raymond, GRAFFEO Michael Philip, JANSKY Nicholas, Lefavour John, MCCAFFREY Maureen, MCLAUGHLIN Ian, NAZZARO David, Rioux Robert F., ROSENBLUM Sam, SCHAEFER Robert D.
Принадлежит:

Systems, components, and methods are disclosed for withdrawing drug from a liquid drug container and transferring drug to a medical device. One or more components may have keying features so that only the correct liquid drug container and medical device are accessed, making sure the medical device is filled with the correct drug. A syringe needle hub may have keying features corresponding to keying features on a cap on the liquid drug container and on the medical device. An alignment device facilitates easy-to-operate filling of a medical device. The alignment device aligns a liquid drug container over a fill port of the medical device and can include components for moving the liquid drug container into engagement with the medical device and for automatically initiating drug transfer to the medical device. A retractable skirt or needle cover protects the needle and is unlocked only when the skirt or needle cover is close to or touching the medical device. 1. A system for filling a medication reservoir of a medical device with a medication , the system comprising:a medical device nest configured for mating with the medical device, the medical device nest comprising at least one keying feature that prevents types of medical devices different from a type of the medical device from mating with the medical device nest;a medication nest configured for mating with a drug container, the medication nest comprising at least one keying feature that prevents types of containers different from a type of the drug container from mating with the medication nest; andmeans for moving medication from the drug container to the reservoir of the medical device.212-. (canceled)13. A method for filling a medication reservoir of a medical device with a medication , the method comprising:mating a medical device nest with the medical device, the medical device nest comprising at least one keying feature that prevents types of medical devices different from a type of the medical device from ...

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Номер записи: 58
06-07-2017 дата публикации

SYSTEMS AND METHODS FOR STORAGE AND DELIVERY OF AMMONIA OXIDIZING BACTERIA

Номер: US20170189454A1
Автор: Heywood James, Jamas Spiros, Weiss Larry, Whitlock David R.
Принадлежит:

This disclosure provides, inter alia, systems and methods for storage and delivery of ammonia oxidizing bacteria, and preparations comprising ammonia oxidizing bacteria. The ammonia oxidizing bacteria may be provided in a container or a kit, with one or more other components that may enhance delivery. The systems and methods herein may be used, for instance, to treat diseases associated with low nitrite levels, skin diseases, and diseases caused by pathogenic bacteria. 1. A container comprising:a first chamber in which is disposed a preparation of an ammonia oxidizing bacteria;a second chamber in which is disposed an activator, wherein the first chamber and the second chamber are separated by a barrier provided to prevent fluid communication between the first chamber and the second chamber.2. The container of claim 1 , wherein the activator comprises a buffer solution.3. The container of any one of - claim 1 , wherein the activator comprises at least one of ammonia claim 1 , ammonium ions claim 1 , and urea.4. The container of any one of - claim 1 , configured such that upon actuation of the container claim 1 , the preparation of ammonia oxidizing bacteria and the activator are mixed.5. The container of any one of - claim 1 , wherein the container comprises a delivery system.6. The container of claim 5 , wherein the delivery system comprises a pump.7. The container of any one of - claim 5 , wherein one of the first chamber and the second chamber is disposed within the other.8. The container of any one of claims 7 , wherein the second chamber is disposed within a compartment claims 7 , and the compartment is disposed within the first chamber.9. The container of claim 7 , wherein the first chamber is disposed within a compartment claim 7 , and the compartment is disposed within the second chamber.10. The container of any one of - claim 7 , wherein the second chamber comprises a controlled release material claim 7 , e.g. claim 7 , slow release material claim 7 , and ...

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Номер записи: 59
11-06-2020 дата публикации

Method for Producing Medically-Deliverable Intravenous Solution

Номер: US20200179597A1
Автор: Scalise Michael B.
Принадлежит:

A device, kit, and method for producing medically-deliverable intravenous solution may include supplying a water to a housing, pumping the water through the housing while purifying the water, metering concentrated intravenous solution into the water to create a medically-deliverable intravenous solution, and dispensing the medically-deliverable intravenous solution, such as immediate intravenous infusion to a patient. 1. A method of intravenous administration of a medically-deliverable intravenous saline solution to a patient , the method comprising:supplying water to a housing;pumping the water through the housing while purifying the water;metering a concentrated intravenous saline solution into the water so that the concentrated intravenous saline solution and the water are mixed to create a medically-deliverable intravenous saline solution; andintravenously infusing the medically-deliverable intravenous saline solution to the patient.2. The method of claim 1 , wherein the supplying step includes supplying the water from at least one of a water supply container and a regional water supply.3. The method of claim 1 , further including adjusting a P.H. of the supplied water.4. The method of claim 3 , wherein the adjusting a P.H. of the supplied water includes adding HCl to the supplied water in a P.H. adjustment chamber.5. The method of claim 3 , further including sensing a P.H. of the supplied water before adjusting a P.H. of the supplied water based on the sensed P.H of the supplied water.6. The method of claim 1 , further including receiving the concentrated intravenous solution and the water in a mixing chamber after the pumping and metering steps and before the intravenously infusing step.7. The method of claim 6 , further including transferring the concentrated intravenous solution and the water along a mixing channel before receiving the concentrated intravenous solution and the water in the mixing chamber.8. The method of claim 6 , further including filtering ...

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Номер записи: 60
14-07-2016 дата публикации

Closed vial fill system for aseptic dispensing

Номер: US20160199257A1
Автор: Dennis Eshima, Derrick ALCAIDE, Eric HASSENPFLUG, Jim GLEESON, Jim PRESCOTT, Mehmet HUSNU, Scott N. Danhof
Принадлежит: Cardinal Health 414 LLC

A closed path vial fill system includes a bulk product vial, a peristaltic pump operated by a stepper motor, a dispensing manifold assembly to which may be coupled at least one final product vial, an optional quality check station, and an optional waste collection system. A concentration, activity, and volume (CAV) sensor may be incorporated into the system to receive a radiopharmaceutical product directly from a synthesizing unit. A control system may be integrated into the system to provide automated control of various aspects of the radiopharmaceutical dispensing process. The system is used to aseptically dispense finished radiopharmaceuticals into receiving vessels, such as a Quality Control vial, a sterility vial, and/or final product vials, while providing users an efficient means for removing and discarding contaminated disposable components.

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Номер записи: 61
13-07-2017 дата публикации

Medical Fluid Transfer and Injection Apparatus and Method

Номер: US20170196771A1
Автор: Hooven Michael D., HUDDLESTON Matthew J., Palmer Joetta Renee, Stefanchik David
Принадлежит:

Drug delivery system, injection device, transfer apparatus, vial holder and method of administering and transferring are disclosed which provide for passive warming of chilled injectable transferred through the transfer apparatus and into the injection device. The injection device may include a skin-facing surface including a skin boundary displacement extension or structure around a needle injection site to create a high pressure zone in the tissue. Radio frequency tracking and monitoring features for tracking patient compliance also may be provided. 1. A drug delivery system for the transfer and administration of an injectable liquid drug into a subject comprising:a transfer apparatus including an injection device docking station, an injectable inlet for receiving a chilled injectable having a temperature in range of about 2° C.-about 8° C., a fluid passageway communicating between the injectable inlet and the injection device docking station;an injection device comprising an expandable chamber including an inlet that is configured for placement into fluid communication with the transfer apparatus fluid passageway when the injection device is received in the injection device docking station; andthe transfer and injection device being configured such that when at ambient temperature of about 15° C.-about 32° C., the temperature of a single dose of chilled injectable that is transferred through the transfer apparatus into the injection device is passively increased by at least about 5° C.-about 25° C.2. The drug delivery system in accordance with in which the passageway has a mass not less than the mass of the injectable dose.3. The drug delivery system in accordance with in which the fluid flow path comprises a material of high thermal conductivity.4. The drug delivery system in accordance with in which the fluid flow path comprises a metal or is in contact with a metal mass.5. The drug delivery system in accordance with in which the passageway is configured to ...

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Номер записи: 62
30-07-2015 дата публикации

Liquid drug transfer devices

Номер: US20150209230A1
Автор: Nimrod Lev, Niv Ben Shalom
Принадлежит: Medimop Medical Projects Ltd

Liquid drug transfer devices with universal drug vial adapters for use with a drug vial of a small drug vial and a large drug vial. Some universal drug vial adapters employ the same generally opposite upright flex members for clamping a small drug vial and a large drug vial. Other universal drug vial adapters include a set of minor flex members for clamping a small drug vial and a set of major flex members encircling the set of minor flex members for clamping a large drug vial whereupon the large drug vial underlies the set of minor flex members. Liquid drug transfer devices with a universal injection port connector for attachment on an injection port of an infusion bag.

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Номер записи: 63
21-07-2016 дата публикации

COMPOUNDING SYSTEMS AND METHODS FOR SAFE MEDICAMENT TRANSPORT

Номер: US20160206511A1
Автор: Garfield Jared, Lyon Gregory
Принадлежит: J&J SOLUTIONS, INC. d/b/a Corvida Medical

An automatic or semi-automatic preparation system and process is provided for forming a medicament solution from a vial containing one of a liquid and a non-liquid material. 1. An automatic or semi-automatic preparation system for forming a medicament solution from a vial containing one of a liquid and a non-liquid material , the preparation system comprising: at least one first rail defining a first axis;', 'at least one second rail defining a second axis, the second axis being oriented orthogonal to the first axis;', 'at least one third rail defining a third axis, the third axis being oriented orthogonal to the each of the first axis and the second axis;', 'a first gear belt movably supported on at least one of the first rails, the second rails or the third rails, wherein the first gear belt, the first gear belt is movably supported on a series of sprockets;', 'a second gear belt movably supported on at least one of the first rails, the second rails or the third rails, wherein the second gear belt, the first gear belt is movably supported on a series of sprockets; the first gear belt and the second gear belt being spaced apart from one another and being arranged in parallel with one another;', 'at least one component holder supported on at least one of the first gearbelt and the second gear belt, each component holder being configured to selectively hold a syringe, a vial, a syringe adapter or a vial adapter; and', 'at least one of a rotation station, a transfer station, and a weigh station disposed about the carousel;, 'a carousel configured to provide three axes of motion, the carousel including a manipulator havingwherein the rotation station is configured for inverting and reverting a syringe and vial assembly;wherein the transfer station is configured for transferring material from a vial to a syringe; andwherein the weigh station is configured for weighing at least one of the syringe, the vial, and the syringe and vial assembly.2. The preparation system ...

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Номер записи: 64
18-06-2020 дата публикации

Filling adapter and injection solution transferring system

Номер: US20200188590A1
Автор: Frederick William HAMLIN
Принадлежит: NOVARTIS AG

A filling adapter (12) for connecting a syringe (14) containing an injection solution to an injection device (10), the filling adapter (12) comprises a hollow sleeve (16) and an adapter element (18) accommodated within the sleeve (16), wherein the adapter element (18) comprises a first connecting port (20) adapted to be connected to the syringe (14) and a second connecting port (22) adapted to be connected to the injection device (10), and wherein the adapter element (18) is provided with a through-opening (26) extending therethrough. A cannula (27) protrudes from the second connecting port (22) of the adapter element (18), wherein the cannula (27) is arranged in fluid communication with the through-opening (26) extending through the adapter element (18), and wherein the adapter element (18) further is provided with a venting device (64) which is adapted to vent gas introduced from the syringe (14) into the injection device (10) via the through-opening (26) and the cannula (27) into the ambient.

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Номер записи: 65
20-07-2017 дата публикации

VIAL ADAPTER

Номер: US20170202742A1
Автор: CHENG Marco, PARK Soon, Yeh Jonathan
Принадлежит:

An exemplary vial adapter may include a moveable member, an elongated member with a first passage, a second passage coupled to an expandable first reservoir, and a third passage coupled to an expandable second reservoir. In a first orientation of an exemplary vial adapter, a fluid may be directed through the first passage into the first reservoir or the second reservoir. In a second orientation of an exemplary vial adapter, a fluid may be drawn through the first passage and a fluid drawn through an air passage into the second passage. In a second orientation of an exemplary vial adapter, a fluid may be directed through the first passage and through the third passage into the second reservoir. In a first orientation of an exemplary vial adapter, a moveable member may be activated to direct a fluid from the second reservoir through the third passage. 1. A vial adaptor for coupling with a vial , the vial adaptor comprising:a medical connector interface;an elongated member configured to extend into the vial upon coupling the vial adaptor with the vial;an expandable first reservoir;an expandable second reservoir;a first passage between the medical connector interface and the elongated member;a second passage between a chamber and the elongated member, the first reservoir coupled to the chamber through a first one-way valve that permits flow from the chamber into the first reservoir, and an air passage coupled to the chamber through a second one-way valve that permits flow from the air passage into the chamber; anda third passage between the second reservoir and the elongated member.2. The vial adaptor of claim 1 , wherein the second passage comprises a valve.3. The vial adaptor of claim 2 , wherein the valve is orientation dependent.4. The vial adaptor of claim 2 , further comprising a filter between the chamber and the valve.5. The vial adaptor of claim 4 , wherein the filter is hydrophobic.6. The vial adaptor of claim 1 , wherein the second reservoir is resilient.7. ...

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Номер записи: 66
20-07-2017 дата публикации

System for Closed Transfer of Fluids Having Connector

Номер: US20170203091A1
Автор: Sanders Laurie, Zachek Matthew
Принадлежит:

A system includes a syringe adapter having a first end and a second end with the first end of the syringe adapter configured to be connected to a first container and the second end of the syringe adapter including a lock member having an open position and a closed position. The system also includes a vial adapter having a first end and a second end with the second end of the vial adapter configured to be connected to a second container and the first end of the vial adapter having a locking surface. The lock member includes at least one projection that extends radially outward. The syringe adapter has at least one corresponding projection configured to engage the at least one projection of the lock member to retain the lock member to the syringe adapter. 1. A syringe adapter comprising:a body having a first end and a second end, the body defining an interior space, the first end of the syringe adapter configured to be connected to a first container, the second end of the syringe adapter including a lock member having an open position where the lock member is configured to receive a mating connector and a closed position where the lock member is configured to be engaged with a mating connector, the lock member including at least one radially extending projection configured to engage a corresponding projection of the body to retain the lock member to the body;a seal arrangement positioned within the body, the seal arrangement comprising a membrane carrier and at least one membrane received by the membrane carrier, the membrane carrier configured to move within the body; anda cannula positioned within the body.2. The syringe adapter of claim 1 , wherein the lock member includes at least one axial projection claim 1 , and wherein the axial projection is configured to engage an external surface of the syringe adapter when the lock member is in the open position.3. The syringe adapter of claim 1 , wherein the membrane carrier is biased toward the second end of the body via ...

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Номер записи: 67
05-08-2021 дата публикации

CARTRIDGE SAFETY INJECTION SYSTEM AND METHODS

Номер: US20210236741A1
Автор: DIAZ Stephen H., Leung Mina M., Shluzas Alan E., Tillack Jeff
Принадлежит: Credence Medsystems, Inc.

A system for injecting includes a cartridge body defining a proximal opening and a distal needle interface. The system also includes a plunger member defining a plunger interior and configured to be manually manipulated to insert a stopper member relative to the cartridge body. The plunger member includes a needle retention feature disposed in the plunger interior, an energy-storage member disposed in the plunger interior, and an energy-storage member latching member disposed in the plunger interior. The system further includes a needle hub assembly coupled to the distal needle interface of the cartridge body. The needle assembly includes a needle having a needle proximal end feature, a hub, and a needle latching member configured to couple the needle to the hub. The needle is retractable into plunger interior upon manipulation of the plunger member to actuate the energy-storage member latching member. 1. A system for injecting , comprising:a cartridge body having proximal and distal openings, and a distal cartridge body interface; a longitudinal channel extending longitudinally through the distal cartridge seal, and', 'a sealing gland extending radially into the longitudinal channel;, 'a distal cartridge seal removably coupled to the distal cartridge body interface of the cartridge body, the distal cartridge seal defining'}a stopper member disposed in a cartridge interior of the cartridge body; a needle retention feature disposed in the plunger interior,', 'an energy-storage member disposed in the plunger interior, and', 'an energy-storage member latching member disposed in the plunger interior; and, 'a plunger member having a plunger interior and configured to be manually manipulated to insert the stopper member relative to the cartridge body, the plunger member including'} a needle having a needle proximal end feature,', 'a hub, and', 'a needle latching member configured to selectively prevent the needle from moving proximally relative to the hub,, 'a needle hub ...

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Номер записи: 68
04-08-2016 дата публикации

DEVICE FOR PACKAGING, STORING, AND EXTEMPORANEOUSLY PREPARING A PLURALITY OF ACTIVE PRINCIPLES

Номер: US20160220446A1
Автор: Perovitch Philippe
Принадлежит:

A device for packaging, conserving, and extemporaneously preparing a plurality of active principles, including a reservoir having a compartment for containing a volume of liquid, the reservoir including a neck defining a dispenser opening; a head that is movable relative to the reservoir between a first distal position for conservation and a second proximate position for preparation; a leaktight closure mechanism; and a rupture mechanism for rupturing the closure mechanism. The closure mechanism is formed by a blister that contains at least two active principles and has at least two compartments, each compartment containing an active principle. The blister is fastened on the neck of the reservoir so as to close it, such that after opening the blister by the rupture mechanism, the active principles enter into contact with the liquid and dissolve therein. 1. A device for packaging , conserving , and extemporaneously preparing a plurality of active principles , said device comprising:a reservoir having at least one compartment for containing at least one volume of liquid, said reservoir including a neck that defines a dispenser opening of the reservoir;a head that is movable relative to said reservoir between a first position for conservation, in which said head is in its distal position relative to the reservoir, and a second position for preparation, in which said head is in its proximal position relative to the reservoir;leaktight closure means for closing the neck of said reservoir; andrupture means for rupturing said leaktight closure means;wherein said leaktight closure means are formed by a leaktight blister that contains at least two active principles, said blister having at least two compartments that are separated by longitudinal and/or transverse and/or superposed partitions, each compartment containing an active principle, said blister being fastened on the neck of said reservoir so as to close said reservoir in leaktight manner, such that after opening ...

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Номер записи: 69
11-07-2019 дата публикации

Device for subcutaneous delivery of fluid medicament

Номер: US20190209773A1
Автор: Daniel SHAKI, Dmitry Golom, Eran Shor, Nir Lilach, Ram NADLER, Rami GROSSFELD, Serdar Ozsumer, Shai ALFANDARI, Tamir Ben David, Tsabar Mor, Yoav Tikochinsky
Принадлежит: Neuroderm LTD

An improved device delivers a fluid medicament to the subcutaneous tissue of a user. The device is better suited for patients with Parkinson's Disease and other central nervous system disorders, than conventional infusion devices. The device can include a reusable part including a drive component (e.g., motor) and control electronics and a disposable part including a medicament reservoir. Medicament can be evacuated from the medicament reservoir by a plunger assembly that includes a plunger attached to a lead screw that is rotated by a nut, all within the disposable part. The device can be fluidically coupled with the tissue via a flexible cannula. Various embodiments relate to an improved cannula insertion mechanism that delivers the cannula under a force applied by a spring. Various embodiments relate to improved filling of the device, for example, using a vial adapter and an automated filling station.

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Номер записи: 70
19-08-2021 дата публикации

SYSTEM AND METHODS FOR TREATING CANCER CELLS WITH ALTERNATING POLARITY MAGNETIC FIELDS

Номер: US20210251850A1
Автор: Sharma Vivek K.
Принадлежит:

Systems and method for destroying or inhibiting cancer cells and other rapidly-dividing cells include applying AP magnetic fields having a frequency of 0.5-500 kHz and a field strength of 0.5-5 mT to a target body area that includes the cancer or other rapidly-dividing cells. 1. A method of treating cancer cells in a target body area of a patient , comprising: an alternating polarity (AP) magnetic field generator;', 'one or more AP electromagnetic coils coupled to the AP magnetic field generator, wherein the one or more AP electromagnetic coils are energized by an electrical signal from the AP magnetic field generator to generate an AP magnetic field having at least a first frequency and a first field strength; and', 'a controller to control at least one of the first frequency and the first field strength of the AP magnetic field generated by the one or more AP electromagnetic coils;, 'providing a magnetic field therapy system comprisingcoupling the one or more AP electromagnetic coils to the target body area;generating an AP magnetic field having a first frequency of 0.5-400 kHz and a first field strength of 0.2-5 mT using the one or more AP electromagnetic coils;applying the generated AP magnetic field to the target body area using the one or more AP electromagnetic coils, wherein the AP magnetic field selectively affects the cancer cells to prevent metastasis of the cancer cells, while leaving non-cancer cells substantially unharmed; andtreating the patient during at least a portion of the step of applying the generated AP magnetic field to the target body area with a chemotherapy drug.2. The method of claim 1 , wherein coupling the one or more AP electromagnetic field generator coils to the target body area comprises using a retaining element to maintain the one or more AP electromagnetic coils in close proximity to the target body area claim 1 , and wherein the retaining element is selected from a garment and a bandage.3. The method of claim 2 , wherein the ...

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Номер записи: 71
18-08-2016 дата публикации

Blood component separation device

Номер: US20160235906A1
Автор: Hiroaki TAKUWA, Katsuyuki Sado, Kenta Kaneda, Satoshi Hirai, Shuji Nakamura, Yoshiki Tanaka
Принадлежит: JIMRO Co Ltd, JMS Co Ltd

A blood reservoir ( 20 ) for storing blood includes a first storage section ( 21 ), a second storage section ( 22 ), and a third storage section ( 23 ) that is provided between the first storage section and the second storage section, and communicates with the first storage section and the second storage section. A volume of the blood reservoir ( 20 ) can be adjusted by changing the amount of expansion or contraction of a bellows structure ( 28 ) using a bellows adjustment mechanism ( 83, 93 ).

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Номер записи: 72
26-08-2021 дата публикации

DEVICES AND METHODS FOR PROVIDING HYDROLYZED LIPIDS

Номер: US20210259924A1
Автор: FIRST Eric, Widom David
Принадлежит: ALCRESTA THERAPEUTICS, INC.

Exemplary embodiments of the disclosure may be drawn to a device having a vessel configured to contain a source of lipids and a chamber fluidly connected to an outlet of the vessel. The chamber may contain immobilized lipase positioned within a flow path in the chamber along which the lipids flow when released from the vessel into the chamber. The device may also include an outlet through which the lipids flow after passing through the chamber. 123-. (canceled)24. A device comprising:a vessel configured to store a flowable lipid;a chamber including an inlet and an outlet, wherein the chamber is connected to an opening of the vessel, and wherein the chamber contains lipase; andone of an interface or an output assembly coupled to the chamber, wherein a flow path extends through an opening in the vessel, through the inlet of the chamber, through the outlet of the chamber, and through the interface or the output assembly;wherein at least one of an outlet of the interface or the outlet assembly or the opening of the vessel is configured to retain the flowable lipid within the vessel prior to use of the device.25. The device of claim 24 , wherein the vessel contains the flowable lipid.26. The device of claim 25 , wherein the flowable lipid includes at least one of an oil claim 25 , an infant fortifier claim 25 , docosahexaenoic acid claim 25 , or arachidonic acid.27. The device of claim 24 , wherein the vessel is removably coupled to the chamber.28. The device of claim 24 , wherein the vessel is prefilled.29. The device of claim 24 , wherein the vessel is refillable.30. The device of claim 24 , wherein the flowable lipid is stored under pressure in the vessel.31. The device of claim 24 , wherein the vessel is compressible.32. The device of claim 31 , further comprising a compression roller configured to compress the vessel.33. The device of claim 24 , wherein the chamber comprises a clear or opaque material.34. The device of claim 24 , wherein the vessel is removably ...

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Номер записи: 73
26-08-2021 дата публикации

SYSTEM AND METHOD FOR SAFETY SYRINGE

Номер: US20210260305A1
Автор: DIAZ Stephen H., Leung Mina M., SHANLEY John F., Shluzas Alan E., STEESE-BRADLEY Gary, Thayer Dan, Tillack Jeff
Принадлежит: Credence Medsystems, Inc.

A system for injecting includes a syringe body defining a proximal opening and a distal needle interface. The system also includes a plunger member defining a plunger interior and configured to be manually manipulated to insert a stopper member relative to the syringe body. The plunger member includes a needle retention feature disposed in the plunger interior, an energy-storage member disposed in the plunger interior, and an energy-storage member latching member disposed in the plunger interior. The system further includes a needle hub assembly coupled to the distal needle interface of the syringe body. The needle assembly includes a needle having a needle proximal end feature, a hub, and a needle latching member configured to couple the needle to the hub. The needle is retractable into plunger interior upon manipulation of the plunger member to actuate the energy-storage member latching member. 1. A system for injecting , comprising:a syringe body defining a proximal opening and a distal needle interface; a needle retention feature disposed in the plunger interior,', 'an energy-storage member disposed in the plunger interior, and', 'an energy-storage member latching member disposed in the plunger interior; and, 'a plunger member defining a plunger interior and configured to be manually manipulated to insert a stopper member relative to the syringe body, the plunger member including'} a needle having a needle proximal end feature,', 'a hub, and', 'a needle latching member configured to couple the needle to the hub,, 'a needle hub assembly coupled to the distal needle interface of the syringe body, the needle assembly including'}wherein the needle is at least partially retractable into plunger interior upon manipulation of the plunger member relative to the syringe body to transform the energy-storage member latching member from a latched state to an unlatched state,wherein the energy-storage member latching member is intercoupled between an interior surface of the ...

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Номер записи: 74
10-09-2015 дата публикации

UNIVERSAL NEEDLEFREE BAG ACCESS DEVICE

Номер: US20150250679A1
Автор: Phillips John C., YOW D. Gregory
Принадлежит:

An attachment arrangement has a housing and a needle located within the housing. The arrangement allows administration ports of different sizes to be inserted into and secured within the housing. In certain embodiments, compliant retainers secure the administration port within the housing. In certain other embodiments, the administration port is secured within the housing when the housing is compressed against the administration port by a housing compression element. Once the administration port is secured within the housing, a fluid-tight seal is formed between the attachment device and the administration port. 1. An attachment arrangement for attaching a connector to an administration port of a fluid container , comprising:a housing having a receiving chamber configured to receive the administration port at a first end;a compressible outer housing surface configured to (i) flex outwardly upon insertion of the administration port into the receiving chamber, and (ii) to be compressed inwardly towards a center of the receiving chamber and to secure the administration port in the receiving chamber;a plurality of protrusions axially spaced along the outer housing surface, the protrusions having a diameter that increases towards the first end, anda housing compression element comprising a ring that engages the protrusions to compress the outer housing surface inwardly as the ring is sequentially advanced toward the first end.2. The attachment arrangement of claim 1 , wherein the housing compression element is a slip ring concentrically mounted on the outer housing surface such that movement of the slip ring towards the first end of the housing compresses the housing inwardly.3. The attachment arrangement of claim 1 , wherein the outer housing surface comprises a discontinuous surface separated by axially extending slits.4. The attachment arrangement of claim 4 , wherein the discontinuous surface comprises a plurality of semi-cylindrical members.5. The attachment ...

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Номер записи: 75
01-08-2019 дата публикации

VIAL ADAPTER

Номер: US20190231643A1
Автор: CHENG Marco, PARK Soon, Yeh Jonathan
Принадлежит:

An exemplary vial adapter may include a moveable member, an elongated member with a first passage, a second passage coupled to an expandable first reservoir, and a third passage coupled to an expandable second reservoir. In a first orientation of an exemplary vial adapter, a fluid may be directed through the first passage into the first reservoir or the second reservoir. In a second orientation of an exemplary vial adapter, a fluid may be drawn through the first passage and a fluid drawn through an air passage into the second passage. In a second orientation of an exemplary vial adapter, a fluid may be directed through the first passage and through the third passage into the second reservoir. In a first orientation of an exemplary vial adapter, a moveable member may be activated to direct a fluid from the second reservoir through the third passage. 1. A vial adaptor for coupling with a vial , the vial adaptor comprising:a medical connector interface, an elongated member, and a first passage therebetween;an expandable first reservoir and a second passage, the second passage extending between the expandable first reservoir and the elongated member, and having a first valve that (i) permits movement of a fluid into and out of the first reservoir when the vial adaptor is in a first orientation, and (ii) resists movement of a fluid into the first reservoir when the vial adaptor is in a second orientation, opposite the first orientation; andan expandable second reservoir and a third passage, the third passage fluidly separated from the first passage and extending between the expandable second reservoir and the elongated member, wherein the vial adaptor is configured to direct the fluid out of the second reservoir when the vial adaptor is in the first orientation and the second orientation.2. The vial adaptor of claim 1 , wherein the first passage claim 1 , the second passage claim 1 , and the third passage are fluidly separated from each other.3. The vial adaptor of claim ...

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Номер записи: 76
01-09-2016 дата публикации

DISPOSABLE VIAL HOLDER AND METHOD TO PREVENT NEEDLE STICK INJURIES

Номер: US20160250100A1
Автор: MUSANI Ali I.
Принадлежит: NATIONAL JEWISH HEALTH

A vial holder is provided to protect a user's hand from needle sticks. The holder includes a handle and a shield attached to a distal end of the handle. An opening is formed in the distal end of the handle to receive a vial. The vial is placed through the opening and into a passageway of the handle with the upper end of the vial exposed. A user grasps the handle which holds the vial in a stabilized manner. A needle may then safely approach the vial in which inadvertent slippage or movement of the needle results in contact with the needle against the shield and not contact with the user's hand. 1. A vial holder comprising:a handle having an opening formed at distal end thereof, and a passageway communicating with the opening, the passageway extending a depth within a portion of the handle from the distal end toward a proximal end of the handle;a shield attached to a distal end of the handle, the shield being substantially planar and extending substantially perpendicular to an axis of the handle;a flange connected to and protruding from the opening, and the flange extending radially inward into the passageway;the passageway is tapered commencing at a larger diameter at the opening to a smaller diameter towards the proximal end of the handle; andwherein the vial holder is made as a single member.2. A vial holder claim 1 , as claimed in claim 1 , wherein:the shield is made from a needle impenetrable plastic having a first stiffness, and the handle is made from a plastic having a second lesser stiffness.3. A vial holder claim 1 , as claimed in claim 1 , wherein:the shield is substantially circular shaped.4. A method of preventing needle stick injuries during use of a needle in withdrawing contents of a vial claim 1 , the method comprising:providing a vial holder including a handle having a passageway extending partially through the handle, the handle having a proximal and distal end;providing a shield attached to a distal end of the handle, the shield extending ...

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Номер записи: 77
09-09-2021 дата публикации

SAFETY FLUID DISPENSER

Номер: US20210275398A1
Автор: Atkins, Atkins Lori Jean, Jr. James H.
Принадлежит:

An apparatus that includes a container portion and a coupler portion. The container and coupler are, in one embodiment, mated via an adapter that includes a one-way valve. The coupler includes a second one-way valve. In use, a fluid source, such as a vial, is connected to the coupler. An air source, such as a syringe is also connected to the coupler. Air from the syringe is introduced to the vial via the second one-way valve. The second one-way valve prevents fluid from the vial from being drawn into the syringe. Introduction of air from the syringe into the vial forces fluid from the vial into the container via the first one-way valve. The first one-way valve prevents the fluid from escaping the container. 1. A safety fluid dispenser produced by a manufacturing process comprising: wherein', 'the connector is configured to attach the coupler to an adapter of a container,', 'the holder is configured to hold a fluid source,', 'the first adapter is configured to receive another fluid source,', a fluid from the fluid source into the container via a second valve, and', 'another fluid from the another fluid source into the fluid source via the first valve,, 'the coupler is configured to facilitate transfer of'}, admit the another fluid from the another fluid source into the coupler at the first adapter, and', 'prevent the fluid from traversing the first valve, and, 'the first valve is configured to'}, admit the fluid from the coupler into the container, and', 'prevent fluid flow from the container into the coupler., 'the second valve is configured to'}], 'fabricating a coupler comprising a connector, a first valve, a first adapter, and a holder,'}2. (canceled)3. (canceled)4. The manufacturing process of claim 1 , wherein the coupler is further fabricated to comprise:a first hollow channel configured to introduce the another fluid into the fluid source via the first valve; anda second hollow channel configured to dispense fluid from the fluid source into the container via ...

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Номер записи: 78
01-09-2016 дата публикации

ANTIBODY FORMULATION

Номер: US20160251422A1
Автор: CROMWELL Mary, GOKARN Yatin R., KAMERZELL Timothy J., LI Megan, Liu Hong
Принадлежит:

The invention provides a stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody, optionally, not subjected to prior lyophilization, a buffer maintaining the pH in the range from about 4.0 to about 6.0, and an optional surfactant, methods for making such a formulation, and methods of using such a formulation. 1. A stable aqueous pharmaceutical formulation , the formulation comprising a therapeutically effective amount of an antibody in an arginine buffer , pH 4.0 to 6.0.24-. (canceled)5. The formulation of wherein the arginine actetate concentration in the buffer is from about 25 mM to about 250 mM.611-. (canceled)12. The formulation of claim 1 , further comprising a surfactant.1314-. (canceled)15. The formulation of claim 12 , wherein the surfactant concentration is from 0.0001% to about 1.0%.1617-. (canceled)18. The formulation of claim 1 , wherein the antibody concentration is from about 10 mg/ml to about 250 mg/ml.1921-. (canceled)22. The formulation of claim 1 , wherein the antibody is not subject to prior lyophilization.2332-. (canceled)33. The formulation of wherein the buffer is 200 mM arginine acetate pH 5.2 claim 1 , the surfactant is polysorbate in an amount of about 0.01-0.1% v/v claim 1 , wherein the formulation is stable at a temperature of about 40° C. for at least 28 days34. An article of manufacture comprising a container holding a stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody claim 1 , an arginine acetate buffer from about pH 4.5 to about 6.0 claim 1 , and a surfactant.3536-. (canceled)37. A method for stabilizing an antibody in an aqueous pharmaceutical formulation by combining a therapeutically effective amount of an antibody claim 1 , an arginine acetate buffer from about pH 4.5 to about 6.0 claim 1 , and a surfactant.3839-. (canceled)40. A stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody ...

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Номер записи: 79
30-08-2018 дата публикации

Automated filling systems and methods

Номер: US20180243168A1
Автор: Julian D. Kavazov
Принадлежит: Medtronic Minimed Inc

Various embodiments of the present invention are directed to transferring fluidic media from a vial to a reservoir. In various embodiments, fluidic media may be transferred from the vial to the reservoir by moving a housing portion to move a plunger head located in the reservoir to draw fluidic media from the vial to the reservoir. In other embodiments, fluidic media may be transferred from the vial to the reservoir while the reservoir is held by a holding unit and vibrated by a vibrator to remove air from the fluidic media. In some embodiments, fluidic media may be transferred from the vial to the reservoir by moving a handle operatively connected to a bias member for assisting with the transfer of fluidic media. In other embodiments, the transfer of fluidic media may be assisted by a bias member and a needle connecting atmosphere and the vial.

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Номер записи: 80
08-08-2019 дата публикации

Clean environment for mixing injectable drugs

Номер: US20190240112A1
Автор: Okonski-Fernandez Irene Gabriela, Zerda-Andrews Deborah
Принадлежит:

A clean environment for mixing injectable drugs having a floor and back member made of stainless steel that is L shaped when seen from the side. The base portion sits on top of a drawer assembly. The back portion has accessory retaining compartments mounted on the left and right side that hold accessories necessary for the process of injecting drugs into IV bags. An IV tip holder is magnetically held to the base portion. Integral posts are located on the top portion of the back member to removably retain the end of a standard IV bag. A circular cutout on the base portion allows for the insertion of a plastic cup. 1. a clean environment for mixing injectable drugs comprising:a floor member and back member forming an L shape when viewed from the side;a plurality of holding compartments;a magnetically attached IV tip support member;and a drawer assembly member;said L shaped floor and back member positioned above said drawer assembly member;said holding compartments fixedly positioned on either side of said back member;an IV tip support assembly including spring biased support arms and a magnetic base;L shaped floor and back member made of stainless steel;Said IV tip support assembly capable of being removably retained by said magnetic base.2. A clean environment for mixing injectable drugs as claimed in further comprising an aperture located in said floor member capable of removably retaining a standard one ounce plastic cup.3. A clean environment for mixing injectable drugs as claimed in wherein said back member includes a plurality of integral support posts capable of removably retaining the rear end of a standard IV bag.4. A clean environment for mixing injectable drugs as claimed in wherein said holding compartments are sized for holding items which include but are not limited to a sharps needle containment box claim 1 , a plurality of sanitary alcohol wipes claim 1 , a plurality of lint free wipes claim 1 , a roll of tape and a roll of peel off labels.5. A clean ...

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Номер записи: 81
07-09-2017 дата публикации

Automatic Drug Dispensing System with Medicine Verification

Номер: US20170255760A1
Автор: Lee Chao Young, Zhang Mei
Принадлежит:

A system for automatic verification of medicine type and/or concentration by automatic drug dispensing systems contemporaneous with the compounding and dispensing of the medicine from the system. 1. An automatic drug dispensing apparatus comprising:a cabinet holding a plurality of drugs in labeled containers providing machine-readable labels indicating drug contents, the cabinet providing limited access for restricting unauthorized personnel;a manipulator adapted to transport at least one drug from the cabinet to aid dispensing outlet for receipt of the drug by medical personnel;a sensor adapted to extract a drug signature dependent on a formulation of the drug by measuring properties of the drug imperceptible to a human observer;an electronic computer executing a stored program to:(1) receive a nominal identity of a drug to be dispensed;(2) control the manipulator to select from the cabinet a container having a label matching the nominal identity;(3) obtain from the sensor a measured drug signature of the selected drug in the drug container;(4) use the nominal identity to determine a correct drug signature associated with the drug and to compare the correct drug signature with the measured drug signature; and(5) provide an output indicating if the correct drug signature differs from the measured drug signature by a predetermined amount.2. The apparatus of further including combining a medicine and diluent and measuring the signature of the combined liquid medicine.3. The apparatus of where in the nominal identity includes chemical formulation and concentration and selecting a signature based on both formulation and concentration.4. The apparatus of further including a labeler configured to write the measured drug signature to a label on the plurality of drug containers.5. The apparatus of wherein the measured drug signature is a function of a chemical formulation of the drug.6. The automatic drug delivery apparatus of wherein the correct drug signature and measured ...

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Номер записи: 82
15-08-2019 дата публикации

NON-VENTED VIAL ACCESS SYRINGE

Номер: US20190247279A1
Автор: MANSOUR George Michel, Panian Tyler Devin
Принадлежит:

A syringe includes a plunger having a plunger tube with proximal and distal ends, a center tube with a center passage that extends within the plunger tube, and a balloon disposed over the center tube and sealingly fixed to at least one of the center tube and the plunger tube. The syringe also includes a barrel having a barrel tube having proximal and distal ends and an interior configured to accept a portion of the plunger, a tip fixedly coupled to the proximal end of the barrel tube, a post fixedly attached to the tip and extending within the barrel tube toward the distal end, the tip configured to partially extend into the center passage of the plunger, and a gas passage extending from a proximal end of the tip to the distal end of the post. 1. A vial adapter comprising:a proximal end portion having a needle configured to couple with a vial;a distal end portion comprising a cavity extending into the vial adapter and configured to receive a portion of a syringe therein;a gas passage extending from the cavity through a proximal end of the needle to provide fluid communication between the cavity and the needle; anda liquid passage extending from the cavity through a distal portion of the needle to provide fluid communication between the cavity and the needle.2. The vial adapter of claim 1 , wherein the cavity defines a female luer fitting and is configured to receive a portion of a syringe defining a male Luer fitting.3. The vial adapter of claim 1 , wherein the liquid passage from a distal end portion of the cavity to a distal end portion of the needle.4. The vial adapter of claim 1 , wherein the gas passage extends between the needle and a proximal end portion of the cavity.5. The vial adapter of claim 1 , wherein the gas passage extends through a tip portion of the needle.6. The vial adapter of claim 1 , wherein the liquid passage extends through an exterior side surface of the needle.7. The vial adapter of claim 1 , wherein the gas passage and the liquid passage ...

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Номер записи: 83
07-10-2021 дата публикации

Fluid Processing Based on Inflatable Bags, Mixing System, and Method of Use Thereof

Номер: US20210308011A1
Автор: CAMISANI Julien Pierre, Waridel Olivier
Принадлежит:

A device and a method for mixing a fluid in a specimen bag is provided herein. In one embodiment, the device includes a mechanism for creating a first vortex and a second vortex. The first vortex is on a first side of a bag containing the fluid, and the second vortex is on a second side of the bag. The mechanism includes a first inflatable airbag and a second inflatable airbag. The first inflatable airbag is configured to create the first vortex when inflated and the second inflatable airbag is deflated. The second inflatable airbag is configured to create the second vortex when inflated and the first inflatable airbag is deflated. 1. A device for applying pressure to biological specimens in a specimen bag , the device comprising:a support structure comprising a base plate configured to support the specimen bag,a cover that fits over the support structure, wherein the cover is configured to pivot between an open position and a closed position,means for imparting a displacement to a specimen in the specimen bag and configured to directly contact the single compartment specimen bagwherein the means for imparting the displacement comprises a first element configured to press against and pull away from a first side of the specimen bag and a second element configured to press against and pull away from a second side of the specimen bag, the first and second elements configured to alternate pressing and pulling on and away from the specimen bag.2. The device of claim 1 , further comprising a temperature control means for maintaining the biological specimen at a controlled temperature.3. The device of claim 1 , further comprising an entry tube in fluid communication with the single compartment specimen bag for adding additive to the specimen bag.4. The device of claim 1 , further comprising a CPU configured to control the means for imparting the displacement.5. The device of claim 1 , wherein the alternate pressing and pulling on the specimen bag is carried out at an ...

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Номер записи: 84
15-09-2016 дата публикации

BLOOD CULTURE BOTTLES WITH MECHANISMS FOR CONTROLLED RELEASE OF SUBSTANCES INTO CULTURE MEDIA

Номер: US20160265022A1
Автор: Bailey Kevin, Beaty Patrick Shawn, Brasch Michael A., CHANG XIAOFEI, Feng Liping, Hershner Gary F., Lentz Ammon David, Livingston Dwight, Lotz Gerard, Murray Patrick R., Pohl Brent, Turng Ben, Ursprung Eric, Wiles Timothy M., Yang-Woytowitz Mei, Yeh Ming-Hsiung, Yu Charles C.
Принадлежит: BECTON, DICKINSON AND COMPANY

An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel , a vessel insert , and a cap element . The vessel has a body portion for receiving a biological sample. The vessel insert receives at least one reagent therein. Preferably, the vessel insert is received in a portion of the vessel . The cap element is attached to the vessel to secure the vessel insert in the vessel . During use, the vessel insert is adapted to release its contents when the biological sample is introduced into the body portion of the vessel upon application of an intermixing force to the vessel insert . A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use. 1. An apparatus for a controlled combination of reagents , the apparatus comprising:a vessel having a body portion for receiving a biological sample;a vessel insert for receiving at least one reagent; anda cap element attached to the vessel,wherein the vessel insert is adapted to release its contents when the biological sample is introduced into the body portion of the vessel upon application of an intermixing force to the vessel insert.2. (canceled)3. The apparatus of claim 12 , wherein the insert is tubular-shaped and wherein the vessel has a neck portion extending from the body claim 12 , and wherein the insert is secured in the neck portion of the vessel by the cap element.4. (canceled)5. The apparatus of claim 34 , wherein the intermixing force is applied either automatically or manually to a tapered rod having a proximal end and a distal end claim 34 , and wherein application of the intermixing force causes the distal end of the tapered rod to pierce the vessel insert and release the contents of the vessel insert into the body portion of the vessel wherein the insert is sealed by a sealing element claim 34 , and wherein the tapered rod pierces the sealing element.67-. (canceled)8. ...

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Номер записи: 85
08-10-2015 дата публикации

Primary Packaging for Storage and Administration of Medical and Pharmaceutical Compounds

Номер: US20150283030A1
Автор: SKUFCA Peter
Принадлежит:

A primary packaging for storage and/or administration of medical or pharmaceutical compounds includes a container that has a predetermined filling volume for receiving a medical or pharmaceutical compound. The container is permanently closed at a first end and has an integrally formed, circumferential flange portion at an open second end. The container has a cylindrical barrel that extends between the first end and the flange portion such that the barrel has an inner diameter and outer diameter corresponding to that of a standardized syringe for a nominal volume of the standardized syringe corresponding to the predetermined filling volume. Furthermore, a cross-sectional shape of the flange portion corresponds to the cross-sectional shape of a flange of a standardized vial. The primary packaging also includes a closure element that is adapted to fit tightly on the flange portion and into the barrel for sealing the open second end of the container. 118-. (canceled)19. A device comprising:a container with a cylindrical barrel, a permanently closed first end and an open second end, wherein a circumferential flange portion is integrally formed around the open second end and extends radially from the open second end;a closure element with a fitting portion and a support portion, wherein the fitting portion fits tightly into the open second end, wherein the support portion seals the open second end by contacting an upper surface of the flange portion; andan aluminum cap that surrounds the closure element and the flange portion of the container, wherein the aluminum cap has a central opening.20. The device of claim 19 , further comprising:a plastics element releasably fitted over the aluminum cap so as to provide access to the closure element through the central opening when the plastics element is flipped off.21. The device of claim 19 , further comprising:a plastics element with a flat lower surface that rests on the support portion of the closure element, wherein the ...

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Номер записи: 86
04-10-2018 дата публикации

APPARATUS AND METHOD FOR MONITORING AND CONTROLLING THE FILLING OF A CONTAINER WITH A PHARMACEUTICAL FLUID IN AN ASEPTIC ENVIRONMENT

Номер: US20180282008A1
Автор: DIAZ GUERRERO Carlos Alberto
Принадлежит:

The present invention involves a system and method for monitoring and controlling the aseptic dispensing of a pharmaceutical fluid into containers. The system employs a pharmaceutical fluid dispensing head to dispense droplets of the pharmaceutical fluid along a droplet path into the container and a droplet monitoring system to monitor the droplets produced and dispensed. The volume of at least one droplet is determined based on images of the droplet falling along the droplet path. The volume of pharmaceutical fluid dispensed is determined from the volume of the droplets. The pharmaceutical fluid dispensing head and the droplet monitoring system may be mutually integrated and may be used in systems using different mechanisms for moving containers, including rotary stage systems and robotic arms. 1. In a device specially adapted for bringing pharmaceutical products into particular physical or administering forms , a method for aseptically dispensing a predetermined amount of pharmaceutical fluid into a pharmaceutical container using a processor , the method comprising:providing a sterilizable chamber capable of maintaining an aseptic condition, the chamber comprising a pharmaceutical fluid dispensing head configured for producing droplets of the pharmaceutical fluid and a droplet monitoring system comprising a digital imager and an associated processor;establishing within the sterilizable chamber an aseptic condition;providing within the sterilizable chamber an aseptic pharmaceutical container;starting the dispensing of a plurality of droplets of the fluid from the dispensing head into the container along a droplet path;obtaining from the imager a plurality of images of at least one of the plurality of droplets along the droplet path; andthe processor determining from the plurality of images if the predetermined volume of fluid was dispensed into the container, and stopping the dispensing of droplets when the predetermined volume of fluid is dispensed into the ...

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Номер записи: 87
12-09-2019 дата публикации

DRUG DELIVERY DEVICE AND TRANSFER STATION

Номер: US20190275243A1
Автор: Deck Frank, List Hans
Принадлежит:

A drug delivery device comprises first and second liquid drug reservoirs and first and second outlet ports. A drive is configured for expelling a first liquid drug from the first reservoir to the first outlet port and for expelling a second liquid drug from the second reservoir to the second outlet port. A memory is provided that contains a drug dosing scheme specifying a desired liquid drug type, and at least one sensor is provided that detects information concerning the type of liquid drug contained in the first and/or second reservoir. A processor receives the information from the at least one sensor and thereby determines the type of liquid drug retained in the first reservoir and/or the second reservoir, and uses the drug dosing scheme and the determined type of liquid drug to operate the drive. Associated devices this disclosure and methods are also disclosed. 1. A method for operating a drug delivery device having first and second liquid drug reservoirs , first and second outlet ports , and a drive configured for expelling liquid drug from the first and second reservoirs to first and second outlet ports , respectively , the method comprising:storing in a memory a drug dosing scheme specifying a desired liquid drug type;using a sensor to detect information concerning the type of liquid drug contained in the first and/or second reservoir; and (i) receive the information from the sensor and thereby determine the type of liquid drug retained in the first reservoir and/or the second reservoir, and', '(ii) use the drug dosing scheme and the determined type of liquid drug to operate the drive., 'using a processor to2. The method of claim 1 , further comprising using the processor to operate the drive to deliver the desired liquid drug from the first reservoir or second reservoir to the respective first or second outlet port.3. The method of claim 1 , wherein the stored drug dosing scheme specifies that the first reservoir must contain the desired liquid drug type ...

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Номер записи: 88
22-10-2015 дата публикации

System for Closed Transfer of Fluids

Номер: US20150297454A1
Автор: Sanders Laurie, Zachek Matthew
Принадлежит:

A syringe adapter includes a housing having a first end and a second end with the first end configured to be secured to a first container, a cannula having a first end and a second end with the second end positioned within the housing, and a collet having a first end and a second end with at least a portion of the collet received within the housing. The collet includes a body defining a passageway, a seal member received by the passageway, and an arcuate, resilient locking member connected to the body of the collet. The collet is movable from a first position where the locking member is open to receive a mating connector to a second position where radially outward movement of the locking member is restricted. 1. A syringe adapter comprising:a housing having a first end and a second end, the first end configured to be secured to a first container;a cannula having a first end and second end, the second end of the cannula positioned within the housing;a collet having a first end and a second end, at least a portion of the collet received within the housing, the collet comprising a body defining a passageway, a seal member received by the passageway, and an arcuate, resilient locking member connected to the body of the collet, the collet is movable from a first position where the locking member is open to receive a mating connector to a second position where radially outward movement of the locking member is restricted.2. The syringe adapter of claim 1 , wherein the locking member is connected to the body via a plurality of arms.3. The syringe adapter of claim 2 , wherein the locking member is ring-shaped and defines an opening extending in a direction perpendicular to a longitudinal axis of the collet.4. The syringe adapter of claim 2 , wherein the locking member is a continuous ring having a plurality of notches configured to permit the locking member to expand radially outward.5. The syringe adapter of claim 2 , wherein the locking member protrudes radially inward ...

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Номер записи: 89
22-10-2015 дата публикации

MIXING SYRINGE

Номер: US20150297457A1
Автор: Buder Christopher, Koss Andrew, Righter Anastasia
Принадлежит:

In some examples, a mixing syringe includes a fluid housing defining an internal housing chamber for storing a medical agent, and a fluid outlet. An outer plunger is disposed within the internal housing chamber of the fluid housing. The outer plunger includes an outer barrel defining a barrel cavity and an outer plunger head connected to the outer barrel. The outer plunger is adapted for longitudinal movement within the internal housing chamber of the fluid housing. The outer plunger head defines a flow passage whereby, upon movement of the outer plunger the medical agent passes from the internal housing chamber through the flow passage into the barrel cavity of the outer plunger. An inner plunger is adapted for longitudinal movement relative to the outer plunger to force the medical agent through the flow passage of the outer plunger head for disposition through the fluid outlet of the fluid housing. 1. A mixing syringe comprising:a fluid housing defining an internal housing chamber and a fluid outlet in communication with the internal housing chamber;an outer plunger disposed within the internal housing chamber of the fluid housing, the outer plunger defining a cavity and comprising an outer plunger head defining a flow passage between the cavity and the internal housing chamber, wherein the outer plunger is configured to move relative to the fluid housing between a proximal position and a distal position; andan inner plunger at least partially disposed within the cavity defined by the outer plunger, the inner plunger being configured to move between a retracted position and an advanced position relative to the outer plunger,whereby, when the outer plunger is in the distal position and fluid is disposed in the cavity of the outer plunger, movement of the inner plunger toward the advanced position causes the inner plunger to force the fluid through the flow passage of the outer plunger head and through the fluid outlet of the fluid housing.2. The mixing syringe of ...

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Номер записи: 90
13-10-2016 дата публикации

SAFETY FLUID DISPENSER

Номер: US20160296421A1
Автор: Atkins, Atkins Lori Jean, Jr. James H.
Принадлежит:

An apparatus that includes a container portion and a coupler portion. The container and coupler are, in one embodiment, mated via an adapter that includes a one-way valve. The coupler includes a second one-way valve. In use, a fluid source, such as a vial, is connected to the coupler. An air source, such as a syringe is also connected to the coupler. Air from the syringe is introduced to the vial via the second one-way valve. The second one-way valve prevents fluid from the vial from being drawn into the syringe. Introduction of air from the syringe into the vial forces fluid from the vial into the container via the first one-way valve. The first one-way valve prevents the fluid from escaping the container. 1. An apparatus comprising: the container comprises a first adapter,', 'the first adapter comprises a first valve; and, 'a container, wherein'} the coupler is attached to the first adapter,', 'the coupler comprises a second valve,', 'the coupler is configured to transfer fluid from a fluid source to the container via the first valve, and', 'the coupler is configured to prevent any of the fluid from the fluid source from traversing the second valve., 'a coupler, wherein'}2. The apparatus of claim 1 , further comprising: the one or more applicators are stored in the container;', 'the one or more applicators comprise absorbent material; and', 'the one or more applicators comprise markings indicating that the one or more applicators comprise a first agent., 'one or more applicators, wherein'}3. The apparatus of claim 2 , further comprising:a positioner configured to secure the one or more applicators in the container.4. The apparatus of claim 1 , whereinthe container comprises a removable cover, andthe removable cover is configured to be sealed to preserve sterility of the container and the one or more applicators.5. The apparatus of claim 2 , whereinthe container is rigid.6. The apparatus of claim 1 , whereinthe first valve comprises a one-way valve configured to ...

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Номер записи: 91
19-09-2019 дата публикации

Device, Kit, and Method for Producing Medically-Deliverable Intravenous Solution

Номер: US20190282755A1
Автор: Scalise Michael B.
Принадлежит:

A device, kit, and method for producing medically-deliverable intravenous solution may include supplying a liquid to a housing, pumping the liquid through the housing while purifying the liquid, metering concentrated intravenous solution into the liquid to create a medically-deliverable intravenous solution, and dispensing the medically-deliverable intravenous solution. 1. A device for producing medically-deliverable intravenous saline solution from a source of water , the device comprising:a housing;a conduit connected to the housing having an inlet and an outlet, the inlet attachable to the source of water;a purification device located along the conduit downstream of the inlet for purifying the water;a pump within the housing for pumping the water through the conduit;a container connectable to the housing holding a concentrated intravenous saline solution, the container having an outlet in communication with the conduit;a metering device for dispensing the concentrated intravenous saline solution from the container into the water; anda controller connected to the housing for controlling the pump and the metering device so as to create the medically-deliverable intravenous saline solution and deliver the medically-deliverable intravenous saline solution to the outlet.2. The device of claim 1 , further including at least one additional container for supplying a medical liquid and at least one additional metering device for dispensing the medical liquid from the at least one additional container into the water.3. The device of claim 2 , further including a pH adjustment chamber in the housing claim 2 , the at least one additional container supplying a ail adjusting liquid for adjusting the pH of the medically-deliverable intravenous saline solution.4. The device of claim 3 , wherein the pH adjusting liquid includes HCl claim 3 , and wherein the pH adjustment chamber is upstream of the mixing chamber.5. The device of claim 3 , further including a sensor in ...

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Номер записи: 92
29-10-2015 дата публикации

SYSTEMS AND METHODS FOR FILLING INOCULATIONS

Номер: US20150305980A1
Автор: LiVolsi Robert F.
Принадлежит:

Embodiments disclosed herein describe systems and methods for systems and methods to dynamically filling inoculations in proper quantities. Embodiments are directed towards a multi-dose prefilled reconstituted device (MPRD) that is configured to automatically prepare a plurality of vials for inoculations quickly and accurately, wherein the MPRD is a transportable device that may be moved from a laboratory environment to a field environment and/or a clinical environment. 1. A multi-dose prefilled reconstituted device comprising:a diluent cartridge configured to store at least one diluent for an inoculation, the diluent cartridge including diluent reservoirs configured to store the at least one diluents and a first unique identifier;a carousel or a linear cartridge configured to store a plurality of vials and a second unique identifier;a housing of the multi-dose prefilled reconstituted device having a first interface being configured to receive the diluent cartridge and a second interface being configured to receive the carousel;a memory device configured to store a mapping between the diluent cartridge and the carousel, the mapping being based on the first unique identifier and the second unique identifier, the mapping including a number of the plurality of vials within the carousel, medication associated with each of the plurality of vials, the amount of diluent within the diluent cartridge, a lower temperature threshold associated with the carousel, and an upper temperature threshold associated with the carousel;an injection interface configured to receive diluent from the diluent cartridge and place the diluent into at least one of the vials within the carousel based on the mapping.2. The device of claim 1 , wherein the injection interface includes a syringe that is configured to insert the diluent from the diluent cartridge into a vial of the plurality of vials positioned below the syringe.3. The system of claim 1 , wherein the carousel is configured to rotate ...

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Номер записи: 93
19-10-2017 дата публикации

FORMULATIONS OF AMINOGLYCOSIDES AND FOSFOMYCIN IN A COMBINATION HAVING IMPROVED CHEMICAL PROPERTIES

Номер: US20170296562A1
Автор: Montgomery Alan Bruce
Принадлежит:

The present invention is synergistic antibiotic compositions having pH adjusted profiles for manufacturing combination, and administration, particularly for patients at risk or suffering from ventilator-associated pneumonia (VAP) and ventilator associated tracheal (VAT) bronchitis. Antibiotic compositions containing fosfomycin and aminoglycosides having individually predetermined and selected pH ranges are manufactured and stored for in combination prior to aerosolization, preferably with a specially designed in-line nebulizer attached to a ventilator. 1providing a first component comprising an amikacin chloride solution having a concentration greater than 50 mg/ml and a first pH between about 6.5 and about 7.5;providing a second component comprising a fosfomycin solution having a concentration greater than 20 mg/ml and a second pH between about 7.5 and 8.5, and wherein the difference between the first pH and the second pH is less than 2.0;combining the first component and the second component; andadministering the combination of the first and second component as an aerosol.. A method to treat pneumonia with a multi-component antibiotic composition comprising: This application claims the benefit of U.S. Provisional Application No. 61/870,102 tiled Aug. 26, 2013; which application is incorporated herein by reference.A number of justifications exist for formulating two or more antibiotics into a combined formulation, including targeting bacterial infections having more than one organism or type of organism where each requires a different antibiotic to treat the infection. Additionally, drug-resistant bacteria greatly increase the amount of antibiotic required for therapeutic treatment. Combinations of antibiotics with synergistic effects would reduce the overall amount of drug required and increase the effectiveness of the treatment.Several combinations of antibiotics are in common use and certain combinations are specifically formulated to be inhaled to treat ...

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Номер записи: 94
10-09-2020 дата публикации

IV SET SPIKE WITH ENHANCED REMOVAL FORCE

Номер: US20200282133A1
Автор: CALLAHAN Ryan, MANSOUR George, Mason Gene, Yu Edmond
Принадлежит:

IV spikes are described herein. An IV spike includes a spike body. The spike body can be formed of a first material and can include a spike portion converging to a point. The IV spike further includes at least one spike flow port formed through the spike body. The IV spike further includes a lower flow port in fluid communication with the at least one spike flow port. The IV spike can also include an overmolded engagement feature disposed around the spike body, wherein the overmolded engagement feature comprises a second material and is configured to retain the IV spike within an IV container. 1. An IV spike , comprising:a spike body comprising a first material and a spike portion converging to a point;at least one spike flow port formed through the spike body;a lower flow port in fluid communication with the at least one spike flow port; andan overmolded engagement feature disposed around the spike body, wherein the overmolded engagement feature comprises a second material and is configured to retain the IV spike within an IV container.2. The IV spike of claim 1 , wherein the first material comprises acrylonitrile butadiene styrene plastic.3. The IV spike of claim 1 , wherein the spike portion comprises a bevel.4. The IV spike of claim 1 , wherein the at least one spike flow port is disposed adjacent to the spike portion.5. The IV spike of claim 1 , wherein the at least one spike flow port comprises a plurality of flow ports.6. The IV spike of claim 1 , wherein the second material comprises a greater coefficient of friction than the first material.7. The IV spike of claim 1 , wherein the second material comprises a thermoplastic elastomer or silicone.8. The IV spike of claim 1 , wherein the overmolded engagement feature extends along an axial length of the spike body.9. The IV spike of claim 1 , wherein the overmolded engagement feature comprises a cylindrical body.10. The IV spike of claim 9 , wherein the overmolded engagement feature is disposed circumferentially ...

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Номер записи: 95
10-09-2020 дата публикации

IV SPIKE FOR USE WITH NON-ISO COMPLIANT IV CONTAINER

Номер: US20200282134A1
Автор: TAN Benjamin Yang Teck
Принадлежит:

An intravenous (IV) spike for administering a medicinal fluid from a container includes an elongate body having an upper portion and a lower portion, and a plurality of screw threads disposed along and protruding radially outward from an outer surface of the lower portion of the elongate body. The elongate body is configured to be coupled to a drip chamber. The outer surface is configured to engage an internal surface of an outlet port of the container in a coupled configuration. In the coupled configuration edges of the screw threads grip and engage the internal surface of the outlet port of the container to create a seal between the lower portion of the elongate body and the outlet port of the container and to retain the body in the outlet port. 1. An intravenous (IV) spike for administering a medicinal fluid from a container , the IV spike comprising:an elongate body having an upper portion and a lower portion, the elongate body configured to be coupled to a drip chamber; the outer surface is configured to engage an internal surface of an outlet port of the container in a coupled configuration; and', 'in the coupled configuration edges of the screw threads grip and engage the internal surface of the outlet port of the container to create a seal between the lower portion of the elongate body and the outlet port of the container and to retain the body in the outlet port., 'a plurality of screw threads disposed along and protruding radially outward from an outer surface of the lower portion of the elongate body, wherein2. The IV spike of claim 1 , further comprising a spike head disposed at the upper portion of the elongate body claim 1 , the spike head having a puncture tip and a puncture base having a fluid inlet at an upper end thereof claim 1 , wherein a fluid channel extends from the fluid inlet claim 1 , through the elongate body claim 1 , and into the drip chamber.3. The IV spike of claim 1 , wherein the internal surface of the outlet port is configured ...

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Номер записи: 96
17-09-2020 дата публикации

Filtration System for Preparation of Fluids for Medical Applications

Номер: US20200289733A1
Автор: Brugger James M., Burbank Jeffrey H.
Принадлежит: NXSTAGE MEDICAL, INC.

A system for filling multiple sterile containers includes a filter with an inlet port and multiple outlet ports, the outlet ports being pre-attached to sterile containers by respective filling lines of each container. Each container has an interior and each of the respective filling lines are connected to a respective container interior. The respective filling lines are sealed to the outlet ports and the containers such that the container interiors are isolated from an external environment except the inlet port, via the filter, forming a combined interior volume which is sterile. A container that is connectable to an outlet port the system has a bladder, a first tube and a second tube connected to the bladder, and a sterilizing filter. The container, the first tube and the second tube, and the sterilizing filter are sterile before water is flowed through the sterilizing filter into the bladder.

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Номер записи: 97
03-11-2016 дата публикации

DUAL-CHAMBER PACK FOR EXTENDED RELEASE SUSPENSION COMPOSITIONS

Номер: US20160317388A1
Автор: BHARGAVA Rahul, Kumar Ashish, MITTAL Bhupesh Kumar, RAMARAJU Kalaiselvan
Принадлежит:

The present invention relates to a dual-chamber pack comprising a first chamber prefilled with a suspension base and a second chamber prefilled with a powder for suspension comprising an active ingredient, wherein upon activation of the dual-chamber pack, the contents of both the chambers are mixed to form an extended release suspension composition which is characterized by having no substantial change in the in-vitro dissolution release profile of the active ingredient upon storage for at least seven days. 2. The dual-chamber pack of claim 1 , wherein the first chamber comprises of a container and the second chamber comprises of an overcap claim 1 , a plunger claim 1 , and a plug with a breakable polymeric membrane.3. The dual-chamber pack of claim 2 , wherein the plunger is prefilled with the powder for suspension in a volume ranging from about 0.5 cc to about 30 cc.4. The dual-chamber pack of claim 1 , wherein the first chamber comprises of a container and the second chamber comprises of a reservoir claim 1 , a biphasic connector claim 1 , a plunger claim 1 , and a plug with a breakable polymeric membrane.5. The dual-chamber pack of claim 4 , wherein the reservoir is prefilled with the powder for suspension in a volume greater than about 30 cc.6. The dual-chamber pack of claim 5 , wherein the reservoir is prefilled with the powder for suspension in a volume ranging from about 30 cc to about 500 cc.7. The dual-chamber pack of claim 4 , wherein the biphasic connector of the second chamber connects the reservoir of the second chamber to the container of the first chamber.8. The dual-chamber pack of claim 2 , wherein the plunger ensures the breakable polymeric membrane remains attached to the plug during activation.9. The dual-chamber pack of claim 2 , wherein the plunger comprise of one or more sharp projections with an essential continuous blunt area.10. The dual-chamber pack of claim 2 , wherein the plug includes one or more moisture barrier additives.11. The dual ...

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Номер записи: 98
02-11-2017 дата публикации

DUAL-CHAMBER PACK FOR PHARMACEUTICAL COMPOSITIONS

Номер: US20170312177A1
Автор: BHARGAVA Rahul, MITTAL Bhupesh Kumar
Принадлежит:

The present invention relates to a dual-chamber pack with a first chamber comprising a container; and a second chamber comprising a reservoir, a biphasic connector, a plunger, and a plug with a breakable polymeric membrane. The container of the first chamber is prefilled with a pharmaceutically acceptable vehicle and the reservoir of the second chamber is prefilled with a solid composition of an active ingredient, wherein the solid composition of the active ingredient is mixed with the pharmaceutically acceptable vehicle to form a liquid pharmaceutical composition upon activation of the dual-chamber pack. 1. A dual-chamber pack comprising:(a) a first chamber comprising a container; and(b) a second chamber comprising a reservoir, a biphasic connector, a plunger, and a plug with a breakable polymeric membrane.2. The dual-chamber pack of claim 1 , wherein the container of the first chamber is prefilled with a pharmaceutically acceptable vehicle and the reservoir of the second chamber is prefilled with a solid composition of an active ingredient.3. The dual-chamber pack of claim 2 , wherein the pharmaceutically acceptable vehicle is mixed with the solid composition to form a liquid pharmaceutical composition upon activation of the dual-chamber pack.4. The dual-chamber pack of claim 3 , wherein the liquid pharmaceutical composition is a solution or a suspension.5. The dual-chamber pack of claim 3 , wherein the liquid pharmaceutical composition is a stable composition.6. The dual-chamber pack of claim 2 , wherein the reservoir of the second chamber is prefilled with the solid composition in a volume greater than about 30 cc.7. The dual-chamber pack of claim 6 , wherein the reservoir of the second chamber is prefilled with the solid composition in a volume ranging from about 30 cc to about 500 cc.8. The dual-chamber pack of claim 1 , wherein the biphasic connector of the second chamber connects the reservoir to the container of the first chamber.9. The dual-chamber pack of ...

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Номер записи: 99
01-10-2020 дата публикации

Syringe Assembly With Ion-Exchange Material

Номер: US20200306138A1
Автор: FRANSSON Jonas
Принадлежит:

A pre-filled syringe is disclosed, comprising a barrel and a plunger, the barrel having an outlet, the barrel containing a pharmaceutically acceptable solution having a non-physiological pH, wherein the syringe further comprises an ion exchange material. The ion exchange material is provided at a position to allow contact with the pharmaceutically acceptable solution upon ejection of the Pharmaceutically acceptable solution from the barrel via the outlet. The ion exchange material is capable of adjusting the pH of the solution from a non-physiological pH, at which the pharmaceutically acceptable solution is stored in order to ensure acceptable shelf life, to a more physiological pH at which the discomfort and/or pain experienced during injection may be alleviated. 1105205. A pre-filled syringe comprising a barrel and a plunger ( , ) , the barrel having an outlet , the barrel containing a pharmaceutically acceptable solution having a non-physiological pH , wherein the syringe further comprises an ion exchange material provided such that the pharmaceutically acceptable solution , when contained within the barrel , does not contact the ion exchange material , and wherein the ion exchange material is provided at a position to allow contact with the pharmaceutically acceptable solution upon ejection of the pharmaceutically acceptable solution from the barrel via the outlet , wherein the ion exchange material is adapted to , upon contact with the pharmaceutically acceptable solution , adjust the pH of the pharmaceutically acceptable solution from a first , non-physiological pH to a second pH , wherein the first , non-physiological pH is in the range of 3-6.6 and/or the second pH is in the range of 6.6-8.0.2. The pre-filled syringe according to claim 1 , wherein the second pH is in the range of 7.0-8.0.3. (canceled)4. The pre-filled syringe according to claim 1 , wherein the pre-filled syringe comprises a separator arranged at a position along an ejection path from the ...

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Номер записи: 100