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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 489484. Отображено 100.
05-01-2012 дата публикации

Cosmetic or dermatological composition containing an active agent which stimulates synthesis of the protein hsp 32 in the skin

Номер: US20120003164A1
Автор: Carine Nizard, Frederic Bonte, Marielle Moreau
Принадлежит: Parfums Christian Dior SA

A dermatological or cosmetological composition for an external topical administration, included together with pharmaceutically and/or cosmetologically acceptable excipients: at least one UVA-stabilizing and/or UVB-stabilizing screening agent, at least one compound capable of activating the endogenous synthesis of Heat Shock Protein (HSP) 32 or a functional peptide fragment of such a protein, and forskolin or any extract containing it.

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Номер записи: 1
05-01-2012 дата публикации

Recombinant fusion protein and polynucleotide construct for immunotoxin production

Номер: US20120003223A1
Автор: Itai Benhar, Yariv Mazor
Принадлежит: Ramot at Tel Aviv University Ltd

The present invention relates to a polynucleotide construct encoding a fusion protein consisting of a domain which binds the immunoglobulin Fc region, genetically fused to a truncated form of Pseudomonas exotoxin A (PE). In particular, the invention discloses the fusion protein, ZZ-PE38, and further provides immunotoxins, formed from complexes of the fusion protein with antibodies for targeted cell killing.

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Номер записи: 2
05-01-2012 дата публикации

Enterovirus Vaccines for Preventing or Treating Type 1 Diabetes (III)

Номер: US20120003240A1
Автор: Hanna-Riikka Honkanen, Heikki Hyöty, Jeffrey Almond, Malin Flodström-Tullberg, Mikael Knip, Minna Pulkki, Olli Laitinen, Outi Tolonen, Sami Oikarinen, Valerie Lecouturier
Принадлежит: Sanofi Pasteur Inc, Vactech OY

Coxsackie B virus CBV1 has been found to be strongly associated with the risk of contracting type 1 diabetes. A vaccine comprising CBV1, a component thereof or an antibody thereto is provided for use in preventing or treating type 1 diabetes. In addition CBV2 was also found to be diabetogenic.

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Номер записи: 3
05-01-2012 дата публикации

Immunogenic compositions for inducing an immune response to hiv

Номер: US20120003265A1
Автор: John H. Eldridge, Maninder K. Sidhu, Michael Egan, Zimra Israel
Принадлежит: WYETH LLC

The invention relates to immunogenic compositions for inducing an immune response to HIV comprising combinations of two, three, or four plasmids, where each plasmid is expressing a defined antigen, which may be a single antigen or a fusion of two or three antigens.

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Номер записи: 4
05-01-2012 дата публикации

Compositions Produced Using Enteric Pathogens and Methods of Use

Номер: US20120003269A1
Автор: Darren E. Straub, Daryll A. Emery, Laura Wonderling
Принадлежит: Epitopix LLC

The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or Salmonella . Examples of Salmonella strains that can be used include, for instance, S. enterica serovar Newport, S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Dublin. Also provided are compositions including polypeptides having a particular molecular weight and a mass fingerprint that includes polypeptide fragments having a particular set of masses, or polypeptides having an amino acid sequence with at least about 95% identity with an amino acid sequence, wherein the polypeptide has seroreactive activity. The present invention also provides methods of making and methods of using such compositions.

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Номер записи: 5
05-01-2012 дата публикации

Cosmetic candle

Номер: US20120003286A1
Автор: Erez Zabari
Принадлежит: Individual

A cosmetic candle comprising tiny grains embedded therein. The grains impart a mechanical property that can be exploited for scrubbing skin to peel off old or dead tissue with a concomitant massaging of molten waxes into the skin. Crushed pits and seeds of olives, apricots, peaches, citrus fruits and/or plums are natural products that can be used as grains in embodiments of the invention. In addition, solid salt grains, such as natural salts from the Dead Sea, or sugar grains, may also be used to that effect.

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Номер записи: 6
05-01-2012 дата публикации

Dispersion composition and method for manufacturing dispersion composition

Номер: US20120003288A1
Автор: Hisahiro Mori
Принадлежит: Fujifilm Corp

The present invention provides: a dispersion composition including a poorly water-soluble polyphenol compound, an emulsifier including a sucrose fatty acid ester, and a water-soluble polymer, in which a content of a polyglycerin fatty acid ester in the composition is 0, or 0.1 or fewer times a total mass of the sucrose fatty acid ester in the composition, and a particle size of the dispersed particles including the poorly water-soluble polyphenol is 200 nm or smaller; and a method for manufacturing the dispersion composition, the method including an oil phase preparation process in which an oil phase is prepared by dissolving one or more oil phase components including the poorly water-soluble polyphenol in a good solvent for the poorly water-soluble polyphenol compound, and a mixing process in which the obtained oil phase and a phase of a poor solvent for the poorly water-soluble polyphenol compound are mixed to obtain the dispersion composition which includes the poorly water-soluble polyphenol compound and includes dispersed particles having an average volume particle size of 200 nm or smaller.

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Номер записи: 7
05-01-2012 дата публикации

Composition Comprising Vascular Endothelial Growth Factor (VEGF) for the Treatment of Hair Loss

Номер: US20120003300A1
Автор: Elliot Isaacs, Toby Cobbledick
Принадлежит: Pangaea Laboratories Ltd

A composition to treat hair loss and enhance hair growth and condition. The composition comprises: i) one or more of VEGF, a VEGF biomimetic peptide, and/or a VEGFR2 receptor agonist; ii) ciclopirox olamine; and iii) a pharmaceutically acceptable carrier.

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Номер записи: 8
05-01-2012 дата публикации

High affinity antibodies to human il-6 receptor

Номер: US20120003697A1
Автор: Ashique Rafique, Eric Smith, Gang Chen, James P. Fandl, Jeanette L. Fairhurst, Joel H. Martin, Kevin J. Pobursky, Margaret Karow, Nicholas J. Papadopoulos, Sean Stevens, Tammy T. Huang
Принадлежит: Regeneron Pharmaceuticals Inc

A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a K D of about 500 pM or less and blocks IL-6 activity with an IC 50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.

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Номер записи: 9
05-01-2012 дата публикации

Compounds for the treatment of pathologies associated with aging and degenerative disorders

Номер: US20120004263A1
Автор: Laura J. Niedernhofer, Paul D. Robbins, Peter Wipf
Принадлежит: University of Pittsburgh

The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject, an effective amount of one or more of the compounds as set forth herein. “Inhibiting a sign of aging or degenerative disorder” means reducing the risk of occurrence, delaying the onset, slowing the progression, and/or reducing the severity and/or manifestation, of a sign of aging or degenerative disorder, and includes, but is not limited to, preventing the occurrence, development or progression of a sign of aging or degenerative disorder.

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Номер записи: 10
05-01-2012 дата публикации

Method of preparation of radiation-curable colored artificial nail gels

Номер: US20120004340A1
Автор: Gary Iannece, Kevin M. Sheran, Lary W. Steffier, Robert R. Raney
Принадлежит: Mycone Dental Supply Co Inc

A method of preparing colored UV-curable artificial nail gel compositions comprising dispersing a pigment in an organic liquid to form a pigment concentrate and mixing the pigment concentrate with a polyfunctional acrylic monomer and/or a polyfunctional acrylic oligomer, and the resultant highly colored artificial nail gel are disclosed.

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Номер записи: 11
12-01-2012 дата публикации

High Energy Visible Light Filter Systems with Yellowness Index Values

Номер: US20120008217A1
Автор: Andrew W. ISHAK, Michael B. Packard, Ronald D. Blum, Sean P. Mcginnis
Принадлежит: High Performance Optics Inc

The present invention relates to ophthalmic and non-ophthalmic systems with blue light filtering and Yellowness Index ranges. UV and IR filtering are also included. Industrial applications are also outlined in the invention.

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Номер записи: 12
12-01-2012 дата публикации

ANTI-Aß OLIGOMER HUMANIZED ANTIBODY

Номер: US20120009179A1
Автор: Nobuyuki SUZUKI, Tsuguo Kubota
Принадлежит: Kyowa Hakko Kirin Co Ltd

An anti-Aβ oligomer humanized antibody which does not bind to Aβ monomers and specifically binds only to Aβ oligomers; an anti-cognitive dysfunction agent, an agent for treating Alzheimer's disease, an agent for suppressing formation of neuritic plaque and an inhibitor of formation of Aβ amyloid fiber comprising the antibody as an active ingredient; a method for at least one of preventing and treating cognitive dysfunction or Alzheimer's disease, comprising the step of administering the antibody; and a method for suppressing progression of Alzheimer's disease, comprising the step of administering the antibody.

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Номер записи: 13
12-01-2012 дата публикации

Monoparamunity inducers based on attenuated rabbit myxomaviruses

Номер: US20120009217A1
Автор: Anton Mayr, Barbara Mayr
Принадлежит: Individual

The present invention relates to monoparamunity inducers based on paramunizing viruses or viral components of a myxomavirus strain from rabbits with typically generalizing disease, to a method for the production thereof and to the use thereof as medicaments for the regulatory optimization of the paramunizing activities for the prophylaxis and therapy of various dysfunctions in humans and animals.

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Номер записи: 14
12-01-2012 дата публикации

Transfection of blood cells with mrna for immune stimulation and gene therapy

Номер: US20120009221A1
Автор: Florian Van Der Mülbe, Ingmar Hoerr, Steve Pascolo
Принадлежит: CureVac AG

The present invention relates to a pharmaceutical composition containing blood cells or haemopoietic cells, e.g. red blood cells (erythrocytes), granulocytes, mononuclear cells (PBMCs) and/or blood platelets, in combination with a pharmaceutically acceptable excipient and/or vehicle, wherein the cells are transfected with at least one mRNA comprising at least one region coding for at least one antigen. The invention further discloses a method of preparing the aforesaid pharmaceutical composition and the use of blood cells transfected in this way for the preparation of drugs or pharmaceutical compositions for immune stimulation against the antigens encoded by the mRNA. The subjects according to the invention are used especially for the therapy and/or prophylaxis of carcinoses or infectious diseases and can also be employed in gene therapy.

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Номер записи: 15
12-01-2012 дата публикации

Modulation of the immune response

Номер: US20120009222A1
Автор: Daniel Griffith Anderson, David-Huy Nhu Nguyen, Kerry Peter Mahon, Robert S. Langer
Принадлежит: Massachusetts Institute of Technology

The present invention provides lipidoids that can be used to modulate the immune response in a subject. Lipidoids are prepared by the conjugate addition of an amine to an acrylate to acrylamide. The lipidoids form complexes or particles with an immunostimulatory polynucleotide, which are then administerd to a subject. Such compositions have been found to stimulate the production of cytokines and increase both humoral and cell-mediate immune response. The invention also provides pharmaceuti-cal compositions thereof and methods for using the same.

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Номер записи: 16
12-01-2012 дата публикации

Respiratory Syncytial Virus Antigenic Compositions and Methods

Номер: US20120009254A1
Автор: James Gorham Boyd, Thomas J. Powell
Принадлежит: Artificial Cell Technologies Inc

Multilayer films comprise polypeptide epitopes from RSV. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films include at least one designed peptide that includes one or more polypeptide epitopes from RSV. Specifically, the multilayer films include two polypeptide epitopes from RSV, such as an epitope that elicits a specific T-cell response such as a cytotoxic T-cell response, and an epitope that elicits a specific antibody response.

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Номер записи: 17
12-01-2012 дата публикации

Compositions for treating skin

Номер: US20120009285A1
Автор: Deepa Bagchi, Edward Dewey Smith, III, Karl Shiqing Wei, Peter Herbert Koenig, Shawn Lynn Mansfield, Stevan David Jones, Sujatha Logou, WEI Ji, Yogesh Suradkar
Принадлежит: Procter and Gamble Co

A personal care composition comprising: at least a first phase and a second phase wherein said first phase comprises a) an aqueous structured surfactant phase comprising STnS where n is between about 0 and about 2.5; b) ; c) a structuring system comprising i. optionally, a non-ionic emulsifier; ii. optionally, from about 0.05% to about 5%, by weight of said personal care composition, of an associative polymer; iii. an electrolyte; and said second phase comprises a) a benefit phase comprising from 1% to about 50%, by weight of said personal care composition, of a hydrophobic benefit agent.

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Номер записи: 18
12-01-2012 дата публикации

5-chloro-4-hydroxy-1-methyl-2-oxo-n-phenyl-1,2-dihydroquinoline-3-carboxamide, salts and uses thereof

Номер: US20120010239A1
Автор: Ulf Tomas Fristedt
Принадлежит: Teva Pharmaceutical Industries LTD

The subject invention provides 5-chloro-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide, its salts and uses.

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Номер записи: 19
19-01-2012 дата публикации

Cosmetic compositions containing arginine and a preservative system containing an alcohol

Номер: US20120012127A1
Автор: Bruno Bavouzet, Lilavati Patel, Maria Pia Rossi
Принадлежит: LOreal SA

Disclosed are cosmetic compositions containing a arginine, and a preservative system comprising from about 0.5% to about 15% of an alcohol, by weight, based on the total weight of the cosmetic composition. Also disclosed are methods for making the cosmetic composition and applying it to keratinous tissue such as skin in order to enhance its appearance.

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Номер записи: 20
19-01-2012 дата публикации

Method of Cleansing Hair

Номер: US20120012130A1
Автор: Charles Winston Saunders, David Johnathan Kitko, Howard David Hutton, III, Jeffrey John Scheibel, Jun Xu, Kenneth Nathan Price, Phillip Richard Green, Stephanie Ann Urbin
Принадлежит: Procter and Gamble Co

Method of cleansing hair comprising: (a) applying a composition to the hair; (b) dissolving and lathering the composition using a water-based solvent; (c) rinsing the hair with a water-based solvent; wherein during the rinsing a total of about 100 gram to about 300 gram of water-based solvent per gram of hair (dry weight) is employed; wherein the composition comprises from about 3 wt % to about 35 wt % of a mixture of at least two compounds of Formula I.

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Номер записи: 21
19-01-2012 дата публикации

Soothing cosmetic or pharmaceutical composition comprising a peptide which activates hmg-coa reductase

Номер: US20120014886A1
Автор: Claude Dal Farra, Jean-Marie Botto, Nouha Domloge
Принадлежит: ISP Investments LLC

The present invention relates to a soothing cosmetic or pharmaceutical composition comprising at least one peptide that activates human HMG-CoA reductase of general formula (I): R 1 -(AA) n -X 1 -Gly-Lys-X 2 -(AA) p -R 2 and sequence SEQ ID No. 1 to SEQ ID No. 10, in a physiologically suitable medium. The present invention further relates to the utilization of this novel peptide as a soothing active principle in a cosmetic composition. The invention further applies to a cosmetic treatment method intended to combat skin irritations.

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Номер записи: 22
19-01-2012 дата публикации

Personal Care Composition Comprising a Near-Terminal Branched Compound

Номер: US20120014900A1
Автор: Charles Winston Saunders, David Johnathan Kitko, Elaine Marie Burt, Jeffrey John Scheibel, John David Carter, Jun Xu, Kenneth Nathan Price, Phillip Richard Green, Stephanie Ann Urbin
Принадлежит: Procter and Gamble Co

A personal care composition comprising: a near-terminal branched compound according to Formula I; a cosmetically acceptable aqueous carrier; wherein the near-terminal branched compound is not comprised in a gel network.

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Номер записи: 23
19-01-2012 дата публикации

Il-1beta binding antibodies and fragments thereof

Номер: US20120014967A1
Автор: Arnold Horwitz, Gang Chen, Linda Masat, Marina Roell, Mary Haak-Frendscho
Принадлежит: Xoma Technology Ltd USA

An IL-1β binding antibody or IL-1β binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL-1β binding polypeptide. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.

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Номер записи: 24
19-01-2012 дата публикации

Avirulent, immunogenic flavivirus chimeras

Номер: US20120014981A1
Автор: Claire Y.H. Kinney, Duane J. Gubler, Natth Bhamarapravati, Richard M. Kinney, Siritorn Butrapet
Принадлежит: Centers of Disease Control and Prevention CDC, Mahidol University, US Department of Health and Human Services

Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural viral proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.

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Номер записи: 25
19-01-2012 дата публикации

Dna vaccine for alzheimer's disease

Номер: US20120014987A1
Автор: Yoh Matsumoto
Принадлежит: TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE

The present invention aims to provide a DNA vaccine for Alzheimer's disease. The present invention provides a recombinant vector which comprises DNA encoding amyloid β and DNA encoding a Th2 cytokine, as well as a DNA vaccine for Alzheimer's disease which comprises this vector.

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Номер записи: 26
19-01-2012 дата публикации

Estrogen receptors and methods of use

Номер: US20120016109A1
Автор: Zhao Yi Wang
Принадлежит: CREIGHTON UNIVERSITY

The present invention provides isolated polypeptides having an amino acid sequence having at least 70% identity to SEQ ID NO:20, wherein the polypeptide has ER-α36 activity. The invention further provides methods for identifying agents that bind to such polypeptides, methods for detecting such polypeptides, and methods for altering the activity of such polypeptides. Also provided are antibodies that specifically bind to an amino acid sequence depicted at SEQ ID NO:1, or an immunogenic fragment thereof, and methods for making and using such antibodies.

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Номер записи: 27
19-01-2012 дата публикации

Transparent Depilatory Article

Номер: US20120016381A1
Автор: Cigdem Asli Hassan, Jamie Anthony Fletcher, Paul Albert Sagel, Paul James Smith, Rajeev Kumar Passi, Shekhar Mitra, Susan Clare Robinson
Принадлежит: Procter and Gamble Co

A depilatory article comprising a substrate and a depilatory composition comprising a keratin reducing agent and being in physical contact with the substrate, preferably forming a coated or impregnated region of the substrate wherein at least a portion of the substrate is transparent.

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Номер записи: 28
26-01-2012 дата публикации

Antibodies against fatty acid synthase

Номер: US20120020978A1
Автор: Patrick J. Muraca
Принадлежит: Nuclea Biotechnologies Inc

The present invention relates to antibodies that immunospecifically bind to FAS and certain FAS related proteins. The invention encompasses human and humanized forms of the antibodies and their use in treating cancers and other proliferative disorders. The invention also relates to FAS-derived peptides useful for preparing the antibodies. Methods and compositions for detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other proliferative disorders using the present antibodies also are disclosed.

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Номер записи: 29
26-01-2012 дата публикации

Formulations and treatments for trichology

Номер: US20120020982A1
Автор: Jon Phillips
Принадлежит: Individual

A formulation for trichological treatment of a patient including, in a dosage in the range of 3 g to 8 g: phytosterols in the range of 200 mg to 2500 mg; the quantitative equivalent of Polygonum multiflorum root 4:1 in 70% EW in the range of 600 mg to 2600 mg; methylsulfonylmethane in the range of 500 mg to 2000 mg; and bovine colostrum in the range of 500 m to 2000 m.

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Номер записи: 30
26-01-2012 дата публикации

Vaccine

Номер: US20120020993A1
Автор: Joann Lisa Prior, Rachel Elizabeth Dean, Sarah Victoria Harding, Timothy Phillip Atkins
Принадлежит: UK Secretary of State for Defence

The present invention relates to a pharmaceutical formulation comprising lipopolysaccharide derived from Burkholderia thailandensis and its various uses, including but not limited to its use in the treatment and/or prophylaxis of meliodosis or amelioration of symptoms associated therewith, and/or glanders or amelioration of symptoms associated therewith.

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Номер записи: 31
26-01-2012 дата публикации

Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof

Номер: US20120021002A1
Автор: Konstantin Ichtchenko, Philip A. Band
Принадлежит: New York University NYU

The present invention relates to an isolated Clostridial neurotoxin propeptide having a light chain region, a heavy chain region, where the light and heavy chain regions are linked by a disulfide bond, and an intermediate region connecting the light and heavy chain regions. An isolated nucleic acid molecule encoding a Clostridial neurotoxin propeptide is also disclosed. Also disclosed is an isolated, physiologically active Clostridial neurotoxin produced by cleaving a Clostridial neurotoxin propeptide, a vaccine or antidote thereof, and methods of immunizing against or treating for toxic effects of Clostridial neurotoxins. Methods of expressing recombinant physiologically active Clostridial neurotoxins are also disclosed. Also disclosed is a chimeric protein having a heavy chain region of a Clostridial neurotoxin and a protein with therapeutic functionality. A treatment method is also disclosed.

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Номер записи: 32
26-01-2012 дата публикации

Corrosion current-generating metal particulates and use thereof

Номер: US20120021014A1
Автор: Brooks Story, Chunlin Yang, James E. Hauschild, Jeannette Chantalat, Jeffrey C. Geesin, Jue-Chen Liu, Julia Hwang, Michael D. Southall, Wei Kong, William R. Parrish, Ying Sun
Принадлежит: Johnson and Johnson Consumer Companies LLC

Metal particulates capable of generating low levels of corrosion current beneficial for pharmaceutical, cosmetic and other medical uses are provided.

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Номер записи: 33
26-01-2012 дата публикации

Dual action dentifrice compositions to prevent hypersensitivity and promote remineralization

Номер: US20120021031A1
Автор: Lynette Zaidel, Michael Prencipe, Suman K. Chopra
Принадлежит: Colgate Palmolive Co

The invention encompasses combinations of bioactive glass composition and potassium salts that are useful in conjunction with delivery agent such as, for example, toothpastes, mouthwashes, and oral gels. In certain embodiments, the compositions of the invention form a rapid and continuous reaction with body fluids (e.g., saliva) to promote the immediate and long-tem release of Ca and P ions to produce a stable crystalline layer deposited onto and into the dentin tubules for the immediate and long term reduction of dentin hypersensitivity and tooth surface remineralization.

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Номер записи: 34
26-01-2012 дата публикации

Combination of an insulin and a glp-1-agonist

Номер: US20120021978A1
Автор: Barbel Rotthauser, Christopher James Smith, Ulrich Werner
Принадлежит: Sanofi Aventis Deutschland GmbH

The invention relates to a drug comprising at least one insulin and at least one GLP-1 receptor agonist.

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Номер записи: 35
02-02-2012 дата публикации

Method of using stem cells to aid in diagnosis

Номер: US20120027678A1
Автор: Albert Scheller, William C. Rader
Принадлежит: Individual

The present invention provides a method for the in vitro culture of embryonic stem cells, wherein the stem cells continue to express no antigen or antigen CD117, and mostly remain undifferentiated during culture. The present invention also relates to purified preparations of embryonic stem cells and for uses of embryonic stem cells in treating a wide variety of conditions, diseases and disorders.

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Номер записи: 36
02-02-2012 дата публикации

Hk1-binding proteins

Номер: US20120027686A1
Автор: Andrew Nixon, Anthony Williams, Daniel J. Sexton, Qi-Long Wu, Robert C. Ladner
Принадлежит: Dyax Corp

The invention features hK1 binding polypeptides as well as compositions comprising such polypeptides and methods of making and using such polypeptides.

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Номер записи: 37
02-02-2012 дата публикации

Thermoreversible collagen

Номер: US20120027732A1
Автор: Sherry L. Voytik-Harbin
Принадлежит: PURDUE RESEARCH FOUNDATION

This invention relates to collagen formulations. More particularly, this invention relates to thermoreversible collagen formulations and methods of their use and preparation.

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Номер записи: 38
02-02-2012 дата публикации

Induction of p53 expression by neutralization of neuropilin-2 for the treatment of cancers

Номер: US20120027779A1
Автор: Camille Grandclement, Christophe Borg, John Wijdenes
Принадлежит: Diaclone SAS, EFS Bourgogne Franche Comte, Université de Franche-Comté

The present invention relates to the use of anti-human neuropilin-2 antibodies, or of ligands of human neuropilin-2 derived from these antibodies, for obtaining a medicament intended to increase p53 expression and to induce tumour cell apoptosis in the context of an anticancer treatment.

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Номер записи: 39
02-02-2012 дата публикации

Genetically programmable pathogen sense and destroy

Номер: US20120027786A1
Автор: Ron Weiss, Saurabh Gupta
Принадлежит: Massachusetts Institute of Technology

Aspects of the invention relate to compositions and methods for using recombinant cells to sense and destroy specific pathogens.

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Номер записи: 40
02-02-2012 дата публикации

Immunological herpes simplex virus antigens and methods for use thereof

Номер: US20120027790A1
Автор: David M. Koelle, Lawrence Corey
Принадлежит: UNIVERSITY OF WASHINGTON

The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.

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Номер записи: 41
02-02-2012 дата публикации

Novel lipids and compositions for the delivery of therapeutics

Номер: US20120027796A1
Автор: David Butler, Jayaprakash K. Narayanannair, Kallanthottathil G. Rajeev, Laxmab Eltepu, Muthiah Manoharan, Muthusamy Jayaraman
Принадлежит: Alnylam Pharmaceuticals Inc

The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures: (Formula (I) or (XXXV)).

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Номер записи: 42
02-02-2012 дата публикации

Antibody gene transfer and recombinant aav therefor

Номер: US20120027798A1
Автор: Kelly Reed Clark, Philip R. Johnson, Jr.
Принадлежит: Nationwide Childrens Hospital Inc

The present invention relates generally to the use of recombinant adeno-associated viruses (rAAV) for gene delivery and more specifically to the use of rAAV to deliver antibody genes to target cells in mammals. Administration of rAAV encoding antibodies that neutralize the HIV-1 virus is exemplified.

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Номер записи: 43
02-02-2012 дата публикации

Natural marine source phospholipids comprising polyunsaturated fatty acids and their applications

Номер: US20120028922A1
Автор: Fotini Sampalis
Принадлежит: Individual

A phospholipid extract from a marine or aquatic biomass possesses therapeutic properties. The phospholipid extract comprises a variety of phospholipids, fatty acid, metals and a novel flavonoid.

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Номер записи: 44
02-02-2012 дата публикации

Pyrazole compounds as crth2 antagonists

Номер: US20120028938A1
Автор: Christoph Hoenke, Dieter Wolfgang Hamprecht, Domnic Martyres, Peter Seither, Ralf Anderskewitz, Thorsten Oost, Wolfgang Rist
Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

The present invention relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2-activity, wherein W, L 1 , L 2 , X, L 3 , Y, R 1 and R 2 are as defined in the specification and claims, to their use as medicaments and to pharmaceutical formulations, containing said compounds or containing a combination of said compounds with one or more active substances.

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Номер записи: 45
02-02-2012 дата публикации

7-azoniabicyclo[2.2.1]heptane derivatives, methods of production, and pharmaceutical uses thereof

Номер: US20120029044A1
Автор: Gwenaella Rescourio, Jurg R. Pfister, Meenakshi S. Venkatraman, Xiaoming Zhang
Принадлежит: Theron Pharmaceuticals Inc

Muscarinic acetylcholine receptor antagonists and methods of using them for the treatment of muscarinic acetylcholine receptor-mediated diseases, such as pulmonary diseases, are provided.

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Номер записи: 46
02-02-2012 дата публикации

Posterior segment drug delivery

Номер: US20120029470A1
Автор: Cary J. Reich, Douglas Sutton, Eugene de Juan, Jr., Hanson S. Gifford, Iii, K. Angela Macfarlane, Kathleen Cogan Farinas, Michael Barrett, Randolph E. Campbell, Yair Alster
Принадлежит: ForSight Vision4 Inc

A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.

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Номер записи: 47
09-02-2012 дата публикации

Use of alkanolamines for thickening oxidative colouring emulsion

Номер: US20120030883A1
Автор: Anja Aechtner, Bernd Noecker, Fariba Ghiasi, Jonathan Wood, Julia Harrèus, Takeshi Iizaki
Принадлежит: KPSS KAO PROFESSIONAL SALON SERVICES GMBH

The present invention relates to the use of alkanolamines for thickening oxidative coloring compositions. More particularly, the present invention relates to the use of alkanolamines for thickening ready to use oxidative coloring composition based on mixing two compositions wherein one comprises at least one oxidative dyeing precursor and the other comprises as least one oxidizing agent.

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Номер записи: 48
09-02-2012 дата публикации

Artificial cells

Номер: US20120034155A1
Автор: Elizabeth A. Sweeney, Gary L. McKnight, Lowell L. Wood, JR., Muriel Y. Ishikawa, Roderick A. Hyde, Wayne R. Kindsvogel
Принадлежит: SEARETE LLC

The present disclosure relates to various embodiments associated with artificial cells, particularly artificial antigen presenting cells, methods of making the same, methods of administering the same, computer systems relating thereto, computer-implemented methods relating thereto, and associated computer program products.

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Номер записи: 49
09-02-2012 дата публикации

Artificial cells

Номер: US20120034157A1
Автор: Elizabeth A. Sweeney, Gary L. McKnight, Lowell L. Wood, JR., Muriel Y. Ishikawa, Roderick A. Hyde, Wayne A. Kindsvogel
Принадлежит: SEARETE LLC

The present disclosure relates to various embodiments associated with artificial cells, particularly artificial antigen presenting cells, methods of making the same, methods of administering the same, computer systems relating thereto, computer-implemented methods relating thereto, and associated computer program products.

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Номер записи: 50
09-02-2012 дата публикации

Aerosol Hairspray Product for Styling and/or Shaping Hair

Номер: US20120034173A1
Автор: Mary Louis Batt, Susanne Birkel
Принадлежит: Procter and Gamble Co

An aerosol hairspray product for styling and/or shaping hair. The product comprises a container for storing a hairstyling formulation and a propellant, wherein the container wall comprises at least about 80% plastic material by total weight of the container. The product also comprises a hairstyling formulation comprising from about 50% to about 99% water by total weight of the hairstyling formulation and propellant. Furthermore, the product comprises less than 15% volatile organic compound by total weight of the hairstyling formulation and propellant.

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Номер записи: 51
09-02-2012 дата публикации

Method of Administering an Antibody

Номер: US20120034243A1
Автор: David Edward Allison, Judith A. Fox, Lee R. Brettman
Принадлежит: Genentech Inc, Millennium Pharmaceuticals Inc

Disclosed is a method for treating a human having a disease associated with leukocyte infiltration of mucosal tissues, comprising administering to said human an effective amount of a human or humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7 integrin. Preferably, no more than 8 mg immunoglobulin or fragment per kg body weight are administered during a period of about one month.

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Номер записи: 52
09-02-2012 дата публикации

Methods of treating secondary bone tumors with antibodies against pdgfr alpha

Номер: US20120034244A1
Автор: Alessandro FATATIS, Nathan Graeme DOLLOFF, Nick LOIZOS
Принадлежит: ImClone LLC, Philadelphia Health and Education Corp

The invention provides methods of treating bone cancer, particularly metastatic bone cancer, by administering an IGF-IR antagonist and/or a PDGFRα antagonist. The invention also provides antibodies that bind to human PDGFRα and neutralize activation of the receptor. The invention further provides a methods for neutralizing activation of PDGFRα, and a methods of treating a mammal with a neoplastic disease using the antibodie alone or in combination with other agents.

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Номер записи: 53
09-02-2012 дата публикации

Influenza Vaccines, Antigens, Compositions, and Methods

Номер: US20120034253A1
Автор: Konstantin Musiychuk, Vadim Mett, Vidadi Yusibov
Принадлежит: Fraunhofer USA Inc

The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and compositions useful in inducing or enhancing an immune response agains influenza antigens. Provided are recombinant protein antigens, compositions, and methods for the production of such antigens in plants. In some embodiments, influenza antigens include hemagglutinin polypeptides, neuraminidase polypeptides, and/or combinations thereof.

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Номер записи: 54
09-02-2012 дата публикации

Dentifrice composition and method of use

Номер: US20120034282A1
Автор: Evangelia Arvanitidou, Joe Vazquez, Mary Horchos, Qing Claire He, Thomas Boyd, Ying Yang
Принадлежит: Colgate Palmolive Co

An exfoliating dentifrice composition is described that contains a plurality of granules and an orally acceptable vehicle. The granules include at least one polymeric binding agent. The composition includes at least one abrasive agent having an average particle diameter of 0.01 mm to 4 mm. Also included are methods of exfoliating an oral cavity soft tissue by use of the composition.

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Номер записи: 55
09-02-2012 дата публикации

Vaccine

Номер: US20120036589A1
Автор: Alexandra Adams, Kim Thompson, Saravanane Poobalane
Принадлежит: University of Stirling

The present invention is concerned with the development of a vaccine against Aeromonas hydrophila for use especially in fish. The invention provides an immunogenic S-layer protein of approximately 50 kDa of A. hydrophila for use in the development of a vaccine, as well as the nucleic acid encoding said protein and vaccines comprising said protein or nucleic acid encoding said protein.

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Номер записи: 56
16-02-2012 дата публикации

Methods of treating pain

Номер: US20120039866A1
Автор: Daniela Salvemini
Принадлежит: St Louis University

The invention relates to methods for treating pain disorders including neuropathic and inflammatory pain and to methods to reduce or eliminate nociceptive tolerance induced by opiate analgesic use by administering an agent that suppresses or blocks S1P biological activity.

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Номер записи: 57
16-02-2012 дата публикации

Human monoclonal antibody against a costimulatory signal transduction molecule ailim and pharmaceutical use thereof

Номер: US20120039874A1
Автор: Katsunari Tezuka, Nobuaki Hori, Takashi Tsuji
Принадлежит: Japan Tobacco Inc

Immunization of human antibody-producing transgenic mice, which have been created using genetic engineering techniques, with AILIM molecule as an antigen resulted in various human monoclonal antibodies capable of binding to AILIM and capable of controlling a variety of biological reactions (for example, cell proliferation, cytokine production, immune cytolysis, cell death, induction of ADCC, etc.) associated with AILIM-mediated costimulatory signal (secondary signal) transduction. Furthermore, it has been revealed that the human monoclonal antibody is effective to treat and prevent various diseases associated with AILIM-mediated costimulatory signal transduction, being capable of inhibiting the onset and/or advancement of the diseases.

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Номер записи: 58
16-02-2012 дата публикации

Method of treatment of neurodementing diseases using isolated, monoclonal, human, anti-b-amyloid antibody

Номер: US20120039897A1
Автор: Marilena Manea, Michael Bacher, Michael Przybylski, Raluca Stefanescu, Richard Dodel
Принадлежит: Philipps Universitaet Marburg

Isolated, monoclonal, human, anti-β-amyloid antibodies are provided which bind to dimeric forms of Ab with higher affinity than to monomeric forms of Ab and when bound to an Aβ polypeptide comprising Aβ(21-37) shield Aβ(21-37) from proteolytic digestion. The antibodies were shown to inhibit fibril formulation and reduce plaque size in vivo and to not bind brain vessel walls. Accordingly, the antibodies are useful in human and veterinary medicine for the treatment and prophylaxis of Alzheimer's disease and other neurodementing diseases. Methods of detecting or measuring the progression of a neurodementing disease also are provided.

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Номер записи: 59
16-02-2012 дата публикации

Anti-Hemagglutinin Antibody Compositions And Methods Of Use Thereof

Номер: US20120039899A1
Автор: Andres G. Grandea, III, Christina L. Boozer, Ole Olsen
Принадлежит: Theraclone Sciences Inc

The present invention provides novel human anti-Influenza antibodies and related compositions and methods. These antibodies are used in the prevention, inhibition, neutralization, diagnosis, and treatment of influenza infection.

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Номер записи: 60
16-02-2012 дата публикации

Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells

Номер: US20120039916A1
Автор: Anne-Laure Flamar, Gérard ZURAWSKI, Jacques F. Banchereau
Принадлежит: BAYLOR RESEARCH INSTITUTE

Compositions and methods for enhancing an immune response with an adjuvant composition comprising: an anti-dendritic cell (DC)-specific antibody or fragment thereof conjugated to at least a portion of a TLR agonist; and a pharmaceutically acceptable carrier are disclosed herein. The conjugate and agonist are each comprised in an amount such that, in combination with the other, are effective to produce the immune response in a human or animal subject in need of immunostimulation.

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Номер записи: 61
16-02-2012 дата публикации

Intergenic regions as insertion sites in the genome of modified vaccinia virus ankara (mva)

Номер: US20120039936A1
Автор: Paul Howley, Sonja Leyrer
Принадлежит: Individual

The present invention relates to novel insertion sites useful for the integration of exogenous sequences into the Modified Vaccinia Ankara (MVA) virus genome. The present invention further provides plasmid vectors to insert exogenous DNA into the genome of MVA. Furthermore, the present invention provides recombinant MVA comprising an exogenous DNA sequence inserted into said new insertion site as medicine or vaccine.

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Номер записи: 62
16-02-2012 дата публикации

Compositions and methods for vaccine and virus production

Номер: US20120039939A1
Автор: Chia Chu, Joseph Shiloach, Michael Betenbaugh, Pratik Jaluria
Принадлежит: JOHNS HOPKINS UNIVERSITY

The present invention features methods of producing immunogenic compositions and viruses, methods of treating and preventing viral infection, and methods of producing an immune response using cells that express a polypeptide selected from the group consisting of: cdk13, siat7e, Iama4, cox15, egr1, gas6, map3k9, and gap43, and a virus.

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Номер записи: 63
16-02-2012 дата публикации

Anti-dandruff compositions with citrus fibers

Номер: US20120040003A1
Автор: Albert Joseph Post, Georgia Shafer, Yury Yarovoy
Принадлежит: Conopco Inc

A shampoo composition is described which includes from 1 to 25% by weight of mild surfactants, from 0.001 to 5% by weight of citrus fibers, from 0.01 to 5% by weight of anti-dandruff zinc salts, and a cosmetically acceptable carrier. The citrus fibers help structure the composition to maintain phase stability, provide appropriate viscosity and achieve deposition of the anti-dandruff zinc salts.

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Номер записи: 64
16-02-2012 дата публикации

Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish

Номер: US20120040010A1
Автор: Brian Carpenter, Moti Harel
Принадлежит: Individual

The invention relates to a composition and a method for manufacturing semi-dry or dry particles containing a mucoadhesive polymer and a bioactive agent such as, but not limited to, an Immunogenic Substance (e.g., a vaccine), that allows the oral or nasal administration and delivery of the bioactive agent essentially unaltered to mucosal surfaces in the animal, including an aquatic animal.

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Номер записи: 65
16-02-2012 дата публикации

Method of detecting progression of a neurodementing disease

Номер: US20120040382A1
Автор: Marilena Manea, Michael Bacher, Michael Przybylski, Raluca Stefanescu, Richard Dodel
Принадлежит: Philipps Universitaet Marburg

Isolated, monoclonal, human, anti-β-amyloid antibodies are provided which bind to dimeric forms of Ab with higher affinity than to monomeric forms of Ab and when bound to an Aβ polypeptide comprising Aβ(21-37) shield Aβ(21-37) from proteolytic digestion. The antibodies were shown to inhibit fibril formation and reduce plaque size in vivo and to not bind brain vessel walls. Accordingly, the antibodies are useful in human and veterinary medicine for the treatment and prophylaxis of Alzheimer's disease and other neurodementing diseases. Methods of detecting or measuring the progression of a neurodementing disease also are provided.

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Номер записи: 66
16-02-2012 дата публикации

Combination of pilocarpin and methimazol for treating charcot-marietooth disease and related disorders

Номер: US20120040940A1
Автор: Daniel Cohen, Ilya Chumakov, Nathalie Cholet, Oxana Guerassimenko, Serguei Nabirochkin
Принадлежит: Pharnext SA

The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related peripheral neuropathies. More particularly, the invention relates to combined therapies for treating said disease by affecting simultaneously muscarinic receptor signaling and thyroid hormone pathway in a subject.

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Номер записи: 67
23-02-2012 дата публикации

Human papilloma virus peptide-specific T-cell response for treatment of warts

Номер: US20120045413A1
Автор: Kevin Kim, Mayumi Nakagawa, Thomas Horn
Принадлежит: Kevin Kim, Mayumi Nakagawa, Thomas Horn

The inventors have treated human patients for warts by intralesional injection of Candida antigen to induce a delayed-type hypersensitivity response in the patients. This creates an immune response that recognizes the antigens of the human papilloma virus (HPV) found in and causing the warts. It was found that the patients showed a response to HPV type 57 L1 peptide 380-412 (a peptide consisting of amino acid residues 380-412 of the protein L1) and HPV type 57 protein E4 (E4 10-30). One embodiment of the invention provides a pharmaceutical composition comprising a polypeptide comprising (a) L1 380-412 (SEQ ID NO:3) or a fragment of at least 8 residues of SEQ ID NO:3 or (b) E4 10-30 (SEQ ID NO:4) or a fragment of at least 8 residues of E4 10-30 (SEQ ID NO:4), wherein the composition is immunogenic in humans.

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Номер записи: 68
23-02-2012 дата публикации

Engineered anti-il-13 antibodies, compositions, methods and uses

Номер: US20120045438A1
Автор: Alexey V. Teplyakov, Ellen Chi, Gopalan Raghunathan, Hong Mimi Zhou, Jill Giles-Komar, Jill M. Carton, Johan Fransson, Juan C. Almagro, Karyn T. O'neil, Linus Hyun, Ronald V. Swanson, Shanrong Zhao, Wendy Cordier, Yiqing Feng
Принадлежит: Centocor Ortho Biotech Inc

The present invention relates to engineered antibodies immuno specific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.

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Номер записи: 69
23-02-2012 дата публикации

Human monoclonal antibodies to ctla-4

Номер: US20120045442A1
Автор: C. Geoffrey Davis, Douglas Charles Hanson, Eileen Elliott Mueller, Jeffrey Herbert Hanke, Jose Ramon Corvalan, Mark Joseph Neveu, Steven Christopher Gilman
Принадлежит: Abgenix Inc, PFIZER INC

In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.

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Номер записи: 70
23-02-2012 дата публикации

Stabilized anti-respiratory syncytial virus (rsv) antibody formulations

Номер: US20120045456A1
Автор: Christian B. Allan, Cynthia N. Oliver, Stephen T. Chang
Принадлежит: MEDIMMUNE LLC

The present invention provides liquid formulations of antibodies or fragments thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. In particular, the present invention provides liquid formulations of antibodies or fragments thereof that immunospecifically bind to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with RSV infection utilizing the liquid formulations of the present invention.

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Номер записи: 71
23-02-2012 дата публикации

Cryptosporidium parvum antigens, antibodies thereto and diagnostic and therapeutic compositions thereof

Номер: US20120045464A1
Автор: J. Neil Simonsen
Принадлежит: Individual

Cloning and expression of genes encoding C. parvum antigenic polypeptides are described as are antibodies that recognize epitopes on these polypeptides. The antigenic polypeptides and antibodies thereto can be used in therapeutic compositions for the prevention and treatment of C. parvum infections, as well as in diagnostic methods for determining the presence of C. parvum infections.

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Номер записи: 72
23-02-2012 дата публикации

Biomolecule Surface Display and Uses Thereof

Номер: US20120045473A1
Автор: Jimmy Kwang
Принадлежит: Temasek Life Sciences Laboratory Ltd

A vaccine for the treatment or prevention of a disease in a subject, wherein said disease is associated with an avian influenza virus, and wherein said vaccine comprises an expression vector comprising a nucleic acid encoding a hemagglutinin peptide, such that in use said hemagglutinin peptide is expressed by said expression vector in said subject.

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Номер записи: 73
23-02-2012 дата публикации

Thermosensitive hepatitis b vaccine

Номер: US20120045511A1
Автор: Ho-Yuan Chou, Hsin-Hsin Shen, Mi-Hua Tao, Tsai-Yu Lin
Принадлежит: Industrial Technology Research Institute ITRI

A thermosensitive hepatitis B vaccine is provided. The thermosensitive hepatitis B vaccine includes an aqueous phase solution comprising a biodegradable thermosensitive hydrogel copolymer; a surface antigen of hepatitis B virus (HBsAg); and a bioactive substance. The thermosensitive hepatitis B vaccine of the disclosure is particularly suitable for being applied in the patients, which are low responsive or non-responsive to conventional hepatitis B vaccine, for enhancing the induction of cell-mediated immune responses and overcoming the HBsAg non-responsiveness.

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Номер записи: 74
23-02-2012 дата публикации

TREATMENT OF CELIAC DISEASE WITH IgA

Номер: US20120045517A1
Автор: Mark Andrew Kroenke, Michael Richard Simon
Принадлежит: Individual

A process for inhibiting symptoms of a subject with celiac disease is provided that includes administration of monoclonal-, or polyclonal-, monomeric, dimeric, or polymeric IgA. Joining secretory component to the IgA limits oral administration degradation. Formulating agents are mixed with the monomeric, dimeric, or polymeric IgA to yield a dosing form of a capsule, tablet, and a suppository. The therapeutic is amenable to enrobement directly through microencapsulation or the dosing form is coated with an enteric coating.

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Номер записи: 75
23-02-2012 дата публикации

ANTI-lgSF4 ANTIBODY AND UTILIZATION OF THE SAME

Номер: US20120046451A1
Автор: Akihiko Takasaki, Atsushi Sugioka, Chiho Muramatsu, Gene Kurosawa, Kazuhiro Morishita, Kazuhiro Suzuki, Kazuki Matsuda, Keiko Ogawa, Mariko Sumitomo, Masachika Azuma, Miwa Morita, Nobuhiro Hayashi, Nobuhiro Takahashi, Sari Fujiyama, Susumu Tsutsumi, Yasushi Akahori, Yoshikazu Kurosawa, Yoshinori Ukai, Yoshitaka Iba
Принадлежит: Institute for Antibodies Co Ltd

It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.

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Номер записи: 76
01-03-2012 дата публикации

Benefit agent containing delivery particle

Номер: US20120052027A9
Автор: David William York, Jiten Odhavji Dihora, Matthew Henry Lang, Peggy Dorothy Sands, Renge Dianna Fossum, Sandra Jacqueline Guinebretiere
Принадлежит: Appleton Papers Inc

The present invention relates to benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the aforementioned particles and compositions. When employed in compositions, for example, cleaning or fabric care compositions, such particles increase the efficiency of benefit agent delivery, there by allowing reduced amounts of benefit agents to be employed. In addition to allowing the amount of benefit agent to be reduced, such particles allow a broad range of benefit agents to be employed.

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Номер записи: 77
01-03-2012 дата публикации

Methods and substances for strengthening and conditioning human fingernails and toe nails

Номер: US20120052029A1
Автор: Francis W. Busch
Принадлежит: Individual

A method and a substance for strengthening fingernails and toe nails of a human being. The method comprises the steps of providing a substance comprising a natural oil composition, a bioactive glass composition and a solvent; applying the substance topically to an outer surface of the fingernail or toe nail; and allowing the substance to dry on the outer surface. The natural oil composition comprises a self-polymerizing oil with an Iodine Value greater than 140. The solvent may be operable to remove nitrocellulose-based fingernail polish. The relative amounts of natural oil composition, bioactive glass composition and solvent are such that the substance is operable to harden and strengthen the fingernail or toe nail.

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Номер записи: 78
01-03-2012 дата публикации

Web material and method for making same

Номер: US20120052037A1
Автор: Alyssandrea Hope Hamad-Ebrahimpour, Andreas Josef Dreher, Brian Patrick Croll, Frank William Denome, Gregory Charles Gordon, John Gerhard Michael, Mark Robert Sivik, Paul Dennis Trokhan, Stephen Joseph Hodson
Принадлежит: Individual

A web material containing one or more active agents and methods for making same are provided.

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Номер записи: 79
01-03-2012 дата публикации

Organosilicones

Номер: US20120052038A1
Автор: Bernard William Kluesner, Joseph Harry JANSEN, Julie Ann Menkhaus, Luke Andrew Zannoni, Marjorie Mossman Peffly, Michael Albert Snyder, Rajan Keshav Panandiker, Rebecca Ann Seger, Robert Joseph Mcchain, Steven Daryl Smith
Принадлежит: Procter and Gamble Co

The present application relates to organosilicones and compositions such as consumer products comprising such organosilicones, as well as processes for making and using such organosilicones and such compositions. Such compositions comprising such organosilicones are easier to formulate, and provide more economical and superior care benefits when compared to current silicone containing compositions.

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Номер записи: 80
01-03-2012 дата публикации

Vaccine composition for prophylaxis and/or therapy of alzheimer's disease

Номер: US20120052086A1
Автор: Atsushi Takahashi, Hisakazu Hasegawa, Mikio Shoji, Takeshi Kawarabayashi, Teruhiko Terakawa, Yasushi Shimada
Принадлежит: Hokko Chemical Industry Co Ltd

A vaccine composition for prophylaxis and/or therapy of Alzheimer's disease, which comprises a fusion protein prepared by inserting a single or tandemly repeated multiple copies of amyloid β antigenic peptide having 5 to 15 continuous amino acid residues derived from the N-terminus of amyloid β peptide into a wild type seed storage protein.

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Номер записи: 81
01-03-2012 дата публикации

Compositions and methods for preventing and treating uterine disease

Номер: US20120052093A1
Автор: Rodrigo Carvalho BICALHO
Принадлежит: CORNELL UNIVERSITY

The present invention relates to methods and compositions for preventing and treating uterine disease, and in particular to vaccines and bacteriophage compositions for treating or preventing puerperal metritis, clinical endometritis and/or subclinical endometritis.

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Номер записи: 82
01-03-2012 дата публикации

Immunogenic epitopes of ngep antigen

Номер: US20120052116A1
Автор: Ira Pastan, Jeffrey Schlom, Kwong-Yok Tsang
Принадлежит: US Department of Health and Human Services

The invention provides a peptide comprising a human cytolytic T lymphocyte (CTL) epitope from the human tumor-associated antigen (TAA) New Gene Expressed in Prostate (NGEP), which can be used in vaccine prevention or therapy of prostate cancer, as well as a nucleic acid encoding the peptide, a vector comprising the nucleic acid, a cell comprising the peptide, nucleic acid, or vector, and compositions thereof.

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Номер записи: 83
01-03-2012 дата публикации

Novel use of compounds for treating and alleviating cellulite

Номер: US20120052141A1
Автор: Joseph Schwager, Karin Wertz, Regina Goralczyk
Принадлежит: DSM IP ASSETS BV

The present invention is directed inter alia to the use of at least one compound selected from the group consisting of (−)-epigallocatechin gallate, resveratrol, eicosapentaenoic acid, docosahexaenoic acid, rose hip extract/concentrate, hydroxytyrosol, lycopene, lutein, β-cryptoxanthin, zeaxanthin and derivatives thereof, for the treatment of cellulite, for the prevention of the development of mild cellulite, for the prevention of the progression of mild cellulite to severe cellulite, for smoothening the micro relief of the skin, for maintaining or increasing the tensile properties of the skin, and/or for reducing the fat mass and the circumference at the hips and thighs, as well as to the corresponding cosmetic and medical methods.

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Номер записи: 84
01-03-2012 дата публикации

BIOLOGICALLY ACTIVE COMPOSITIONS FROM Schisandra chinensis FOR TREATING COLORECTAL CANCER

Номер: US20120052142A1
Автор: John Noel GNABRE
Принадлежит: Dr Chang Naturals LLC

A biologically active composition to treat colorectal cancer includes an extract of the plant Schisandra chinensis and a suitable pharmaceutical formulation. The extract can be at least one of gomisin A, angeloylgomisin H, deoxyschisandrin and gomisin N, showing activities against human tumor cell line HT-29 in the range of about 716 μM to about 43 μM. A suitable pharmaceutical formulation can be any one of a pill, a tablet, a capsule, a liquid solution, a liquid suspension, a powder, an intravenous solution, a gel and a suppository form. The extract is prepared by grinding the dried berries, extracting with hexane, extracting the marc with dichloromethane, extracting the dichloromethane soluble fraction with ethyl acetate, removing fatty materials in the dichloromethane-ethyl acetate soluble fraction with hexane, and fractionating the total hexane insoluble material extract using analytical high performance liquid chromatography equipped with automated repeat injection/collection cycles.

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Номер записи: 85
01-03-2012 дата публикации

Anti-vegf-c antibodies and methods using same

Номер: US20120052566A9
Автор: Anil D. Bagri, Chingwei V. Lee, Germaine Fuh
Принадлежит: F Hoffmann La Roche AG

The invention provides VEGF-C antagonists, such as anti-VEGF-C antibodies, and their use in the prevention and treatment of tumor progression.

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Номер записи: 86
01-03-2012 дата публикации

ISOLATED GENOMIC POLYNUCLEOTIDE FRAGMENTS FROM THE p15 REGION OF ISOLATED GENOMIC POLYNUCLEOTIDE FRAGMENTS FROM THE p15 REGION OF CHROMOSOME 11 ENCODING HUMAN TUMOR SUPPRESSING SUBTRANSFERABLE CANDIDATE 4 (TSSC4)

Номер: US20120053232A1
Автор: James W. Ryan
Принадлежит: RYOGEN LLC

Provided herein are isolated genomic polynucleotide fragments from the from the p15 region of chromosome 11 encoding human and tumor suppressing subtransferable candidate 4 (TSSC4) and methods of use.

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Номер записи: 87
01-03-2012 дата публикации

Aqueous nanoemulsion composition containing conjugated linoleic acid

Номер: US20120053241A1
Автор: Hong Geun Ji, Hye Kyeong Woo, Hyo Gyoung Yu, Soo Dong Kim
Принадлежит: Hwail Pharmaceutical Co Ltd

The present invention relates to an aqueous nanoemulsion composition comprising conjugated linoleic acid. More particularly, the present invention relates to an aqueous nanoemulsion composition comprising 5 to 50 wt % of conjugated linoleic acid, 0.01 to 5 wt % of lecithin, 0.01 to 5 wt % of ethanol as a dissolution aid, 1 to 15 wt % of coemulsifier, 10 to 40 wt % of glycerine and the balance of water.

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Номер записи: 88
01-03-2012 дата публикации

Alkylamido Compounds and Uses Thereof

Номер: US20120053244A1
Автор: Francesca Viti, Salvatore Bellinvia, Sergio Baroni
Принадлежит: Individual

Disclosed herein are compounds that may be specific to PPAR and/or EGF receptors, and methods of making and using same.

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Номер записи: 89
01-03-2012 дата публикации

Methods of Treating Hair Related Conditions

Номер: US20120053245A1
Автор: Francesca Viti, Salvatore Bellinvia, Sergio Baroni
Принадлежит: Individual

Disclosed herein are methods for treating hair related disorders, including compounds that may be specific or modulate PPAR receptors.

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Номер записи: 90
08-03-2012 дата публикации

Foil Applicator

Номер: US20120055500A1
Автор: Astrid Kleen, Carolin Welz, Susanne Hagenow
Принадлежит: Henkel AG and Co KGaA

Foil-type applicator for the selective lightening of keratin fibers, particularly human hair, and use of the applicators for producing targeted lightening effects on the hair.

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Номер записи: 91
08-03-2012 дата публикации

Two component interactive emulsion product

Номер: US20120058062A1
Автор: John C. Carson
Принадлежит: Carson Product Development Inc

The present invention describes, in one aspect, the use of two oppositely charged surfactants as the primary emulsifiers in two separated parts of a product. The emulsifiers are chosen such that when the two parts of the emulsion product are mixed, the emulsifiers react to form water insoluble compounds that are no longer able to function as emulsifiers, thus, the oil phase of the emulsion is precipitated onto the skin along with the emulsifier reaction product. Since none of the deposited materials are water soluble, or capable of functioning as emulsifiers, the deposited oil phase is extremely resistant to being washed off. This technology finds applications in hand and body creams and lotions, baby care products, sunscreens, skin protective products, makeup systems, and automotive and furniture polishes.

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Номер записи: 92
08-03-2012 дата публикации

Anti- integrin antibodies, compositions, methods and uses

Номер: US20120058128A1
Автор: Jill Giles-Komar, Linda Snyder, Marian T. Nakada, Mohit Trikha
Принадлежит: Janssen Biotech Inc

The present invention relates to at least one novel anti-alpha-V subunit antibodies, including isolated nucleic acids that encode at least one anti-alpha-V subunit antibody, alpha-V subunit, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

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Номер записи: 93
08-03-2012 дата публикации

Activated leukocyte composition and uses for wound healing

Номер: US20120058156A1
Автор: Adi Zuloff-Shani, Eilat Bain, Eilat Shinar, Irene Ginis, Marina Bubis, Mitchell Shirvan, Orit Frenkel
Принадлежит: Macrocure Ltd

Disclosed are therapeutic, blood-derived activated leukocyte compositions, methods of making them, and methods of using the compositions to repair or promote the prevention and healing of wounds.

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Номер записи: 94
08-03-2012 дата публикации

Cleaning or cosmetic compositions comprising natural zeolites

Номер: US20120058164A1
Автор: Paul Lap Shun Chan, Philip John Ashenden, Ray John Merchant
Принадлежит: ZEOSOFT Ltd

The invention describes compositions which are useful as cleansers of the skin. The compositions described comprise zeolitic ingredients which are in general softer than known products. The natural zeolitic ingredients are inherently soft. The softness is due to a number of factors including but not limited to younger zeolitic rock types, softer constituent elements, more porous rock types and less dense rock types. The overall softness provided by the compositions according to the invention provides a cleaning product that is softer to the skin, especially the human skin.

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Номер записи: 95
08-03-2012 дата публикации

Purified Plasmodium and Vaccine Compositions

Номер: US20120058543A1
Автор: B. Kim Lee Sim, Minglin Li, Richard E. Stafford, Stephen L. Hoffman
Принадлежит: Sanaria Inc

Disclosed are substantially purified Plasmodium sporozoites and preparations of Plasmodium sporozoites substantially separated from attendant non-sporozoite material, where the preparations of Plasmodium sporozoites have increasing levels of purity. Vaccines and pharmaceutical compositions comprising purified Plasmodium sporozoites are likewise provided. Methods of purifying preparations of Plasmodium sporozoites are also provided.

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Номер записи: 96
08-03-2012 дата публикации

Antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved

Номер: US20120058572A1
Автор: Naruto Katsuragi, Ryuichi Morishita, Yoshiaki Taniyama
Принадлежит: Daiichi Sankyo Co Ltd, Osaka University NUC

The present invention provides an antibody against a periostin isoform having anti-cell adhesive activity, especially an anti-periostin antibody having the ability to neutralize anti-cell adhesive properties, as well as a prophylactic or therapeutic agent for periostin-related diseases comprising the antibody. The present invention also provides methods for detecting and quantifying the periostin isoform in a sample by using the antibody, as well as a method for diagnosing periostin-related diseases comprising measuring the amount of the periostin isoform by the detection or quantification method.

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Номер записи: 97
08-03-2012 дата публикации

Novel kinase modulators

Номер: US20120059001A1
Автор: Govindarajulu Babu, Meyyappan Muthuppalaniappan, Srikant Viswanadha, Swaroop Kumar V.S. Vakkalanka
Принадлежит: Incozen Therapeutics Pvt Ltd, Rhizen Pharmaceuticals SA

The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

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Номер записи: 98
15-03-2012 дата публикации

Method for Treating Psoriatic Arthritis by Administering an Anti-IL-12 Antibody

Номер: US20120063998A1
Автор: Bemard Scallon, David M. Knight, David Peritt, David Shealy, Jill Giles-Komar
Принадлежит: Individual

Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as psoriatic arthritis.

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Номер записи: 99
15-03-2012 дата публикации

Psca: prostate stem cell antigen and uses thereof

Номер: US20120063999A1
Автор: Aya Jakobovitz, Douglas C. Saffran, Owen N. Witte, Robert E. Reiter
Принадлежит: Agensys Inc, UNIVERSITY OF CALIFORNIA

The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.

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Номер записи: 100