17-07-2014 дата публикации
Номер: US20140200257A1
Автор:
Kallanthottathil G Rajeev,
Muthiah Manoharan,
Muthusamy Jayaraman,
Martin Maier,
Jayaprakash K. Nair,
David Butler,
RAJEEV KALLANTHOTTATHIL G,
MANOHARAN MUTHIAH,
JAYARAMAN MUTHUSAMY,
MAIER MARTIN,
NAIR JAYAPRAKASH K,
BUTLER DAVID,
NAIR JAYAPRAKASH K.
The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery. 2. The compound of claim 1 , wherein X is —(CH)—.3. The compound of claim 1 , wherein X is —CH— and Y is —O— claim 1 , —S— claim 1 , —OC(O)— claim 1 , —C(O)O— claim 1 , —OC(O)N(R)— claim 1 , —N(R)C(O)O— claim 1 , —SC(O)N(R)— claim 1 , or —N(R)C(O)S—.4. The compound of claim 1 , wherein X is not —CH—; and Y is —(CRR)— claim 1 , —C(O)— claim 1 , —N(R)— claim 1 , —C(O)N(R)— claim 1 , —N(R)C(O)— claim 1 , —OC(O)N(R)— claim 1 , —N(R)C(O)O— claim 1 , —N(R)C(O)N(R)— claim 1 , —SC(O)N(R)— claim 1 , or —N(R)C(O)S—.5. The compound of claim 4 , wherein Zis —C(O)O— or —C(O)N(R)—.6. The compound of claim 1 , wherein X is —N(R)— claim 1 , —C(O)N(R)— claim 1 , —N(R)C(O)— claim 1 , —OC(O)N(R)— claim 1 , —N(R)C(O)O— claim 1 , —N(R)C(O)N(R)— claim 1 , —SC(O)N(R)— claim 1 , or —N(R)C(O)S—.7. The compound of claim 1 , wherein Y is —N(R)— claim 1 , —C(O)N(R)— claim 1 , —N(R)C(O)— claim 1 , —OC(O)N(R)— claim 1 , —N(R)C(O)O— claim 1 , —N(R)C(O)N(R)— claim 1 , —SC(O)N(R)— claim 1 , or —N(R)C(O)S—.8. The compound of claim 1 , wherein each A is Land each L claim 1 , independently claim 1 , is —OCHCH— claim 1 , —OCHCHCH— claim 1 , or —OCHCH(CH)—.9. The compound of claim 1 , wherein Ris alkoxy.10. The compound of claim 1 , wherein the molecular weight of the compound is between 500 g/mol and 5 claim 1 ,000 g/mol.11. The compound of claim 1 , wherein each of Rand R claim 1 , independently claim 1 , is a Cto Calkyl or a Cto Calkenyl group.12. The compound of claim 1 , wherein the variables q and s are each independently 1 claim 1 , 2 claim 1 , 3 claim 1 , or 4.13. The compound of claim 1 , wherein:{'sub': 1', '2', '12', '20', '12', '20, 'each of Rand R, independently, is a Cto Calkyl or a Cto Calkenyl group;'}{'sub': '2', 'X is —CH—, —O—, —OC(O)—, —C(O)O—, —C(O)NH—, —NHC(O)—, —OC(O)NH—, —NHC(O)O—, or —NHC(O)NH—;'}Y is —O—, —S—, —OC(O)—, —NHC(O)—, —OC(O)NH—, —NHC(O)O—, —NHC(O)NH—, or —SC(O)NH—;a is 1;{'sup': ' ...
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