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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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01-03-2012 дата публикации

BIOLOGICALLY ACTIVE COMPOSITIONS FROM Schisandra chinensis FOR TREATING COLORECTAL CANCER

Номер: US20120052142A1
Автор: John Noel GNABRE
Принадлежит: Dr Chang Naturals LLC

A biologically active composition to treat colorectal cancer includes an extract of the plant Schisandra chinensis and a suitable pharmaceutical formulation. The extract can be at least one of gomisin A, angeloylgomisin H, deoxyschisandrin and gomisin N, showing activities against human tumor cell line HT-29 in the range of about 716 μM to about 43 μM. A suitable pharmaceutical formulation can be any one of a pill, a tablet, a capsule, a liquid solution, a liquid suspension, a powder, an intravenous solution, a gel and a suppository form. The extract is prepared by grinding the dried berries, extracting with hexane, extracting the marc with dichloromethane, extracting the dichloromethane soluble fraction with ethyl acetate, removing fatty materials in the dichloromethane-ethyl acetate soluble fraction with hexane, and fractionating the total hexane insoluble material extract using analytical high performance liquid chromatography equipped with automated repeat injection/collection cycles.

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Номер записи: 1
20-09-2012 дата публикации

Combretum laurifolium mart. extract and methods of extracting and using such extract

Номер: US20120237619A1
Автор: Matthew E. Burow, Peter Koepke, Ven Subbiah
Принадлежит: SelvaMedica LLC

A method of inhibiting COX-2, inhibiting NF-Kappa B activation, treating inflammation, or treating cancer may comprise administering a therapeutically effective amount of an extract of Combretum laurifolium Mart. to a patient. A medicament as described herein may comprise a pharmaceutically acceptable vehicle and a therapeutically effective amount of an extract of Combretum laurifolium Mart. suspended in the vehicle. A method of making an extract of Combretum laurifolium Mart. may comprise creating a component solution by treating Combretum laurifolium Mart. material with an extractor and a solvent and producing an extract by at least partially removing liquid from the component solution. An extract of Combretum laurifolium Mart. may comprise components extracted using various solvents.

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Номер записи: 2
02-05-2013 дата публикации

Cosmetic and/or pharmaceutical compositions and their applications

Номер: US20130108719A1
Автор: André Ulmann, Jean-Frederic Sturer
Принадлежит: Legacy Healthcare Holding Ltd

Compositions are disclosed containing, as active ingredients, an extract of Allium species, an extract of Citrus species and either an extract of Paullinia species and an extract of Theobroma species, or an extract of Salix species and zinc sulphate, and the method of preparation of these compositions, and cosmetic and/or pharmaceutical application of these compositions.

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Номер записи: 3
14-11-2013 дата публикации

Compositions containing as the active ingredient components from salvia sclarea seed

Номер: US20130303617A1
Автор: Dan Schafferman, David Chaimovitsh, Diah Sa'ady, Eli Putievsky, Nativ DUDAI, Zohara YANIV BACHARACH
Принадлежит: Agricultural Research Organization of Israel Ministry of Agriculture , Israel Ministry of Agriculture and Rural Development

The present invention concerns a food supplement comprising Salvia sclarea seeds, or flour, oil or pulp or extracts obtained from the seeds as well as finished food products comprising the food supplement. The present invention further concerns a nutraceutical or cosmetic preparation comprising as an active ingredient Salvia sclarea seeds, or flour, oil or pulp or extracts obtained from the seeds.

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Номер записи: 4
27-03-2014 дата публикации

Method and external preparation for lymphatic slimming

Номер: US20140088548A1
Автор: Satoshi Shinkawa
Принадлежит: Individual

The present invention provides a set of body slimming compositions, for application to a body before irradiating the body with a far-infrared ray in an atmosphere of 50° C. or thereabout. The slimming composition set includes a first external composition containing a cosmetic base, a Bacillus-fig-soybean fermented liquor, a Bacillus-Monascus-angelica-soybean fermented liquor, a Bacillus-longan-soybean fermented liquor, orizanol, tocopheryl acetate, macadamia nut oil, and glucosyl hesperidine, and a second external composition containing a cosmetic base, a Bacillus-persimmon-soybean fermented liquor, a Waltheria indica leaf extract, and ascorbyl tetrahexyldecanoate. The first external composition is applied to a lymphatic node region of the body, and the second external composition is applied to a slimming target region of the body. The composition set of the invention can activate lymph or lipase, whereby a remarkable body slimming effect can be attained.

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Номер записи: 5
06-01-2022 дата публикации

Cannabis Plants with a Cannabinoid Profile Enriched for Delta-9-Tetrahydrocannabinol, Cannabigerol and Tetrahydrocannabivarin

Номер: US20220000056A1
Автор: Cogan Noel, Elkins Aaron Christopher, Rochfort Simone Jane, Spangenberg German Carlos
Принадлежит:

The present disclosure relates generally to new cannabis plants, including parts, extracts and uses thereof, comprising a cannabinoid profile enriched for total THC (i.e., Δ-9-tetrahydrocannabinol (THC) and Δ-9-tetrahydrocannabinolic acid (THCA), total CBG (i.e., cannabigerol (CBG) and cannabigerolic acid (CBGA)), and total THCV (i.e., tetrahydrocannabivarin (THCV) and tetrahydrocannabivarinic acid (THCVA)). 1. A cannabis plant , or a part thereof , comprising a cannabinoid profile enriched for total THC , total CBG and total THCV , wherein the cannabinoid profile comprises a level of total THC and a level of total CBG at a ratio of from about 10:1 to about 100:1 (THC:CBG) , and a level of total THC and a level of total THCV at a ratio of from about 10:1 to about 100:1 (THC:THCV) , wherein the total THC comprises Δ-9-tetrahydrocannabinol (THC) and Δ-9-tetrahydrocannabinolic acid (THCA) , the total CBG comprises cannabigerol (CBG) and cannabigerolic acid (CBGA) , and the total THCV comprises tetrahydrocannabivarin (THCV) and tetrahydrocannabivarinic acid (THCVA); and (a) total CBD, wherein the total CBD comprises cannabidiol (CBD) and cannabidiolic acid (CBDA);', '(b) total CBC, wherein the total CBC comprises cannabichromene (CBC) and cannabichromene acid (CBCA);', '(c) total CBN, wherein the total CBN comprises cannabinol (CBN) and cannabinolic acid (CBNA); and', 'total CBDV, wherein the total CBDV comprises cannabidivarin (CBDV) and cannabidivarinic acid (CBDVA)., 'wherein the level of total THC is greater than the level of a reference cannabinoid selected from the group consisting of2. The cannabis plant of claim 1 , or a part thereof claim 1 , wherein the part is a female inflorescence.3. The cannabis plant of claim 1 , or a part thereof claim 1 , wherein:(a) the level of total THC is at least 80% by weight of the total cannabinoid content of the dry weight of plant material;(b) the level of total CBG is from about 1% to about 10% by weight of the total ...

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Номер записи: 6
04-01-2018 дата публикации

Enhanced Mycelium Growth Medium and Method

Номер: US20180000013A1
Автор: Rubin Jordan Seth
Принадлежит: Functional Fungi, LLC

The invention is a method for enhanced growth of mycelium in culture including the key steps of seed blend choice from among corn, rice, quinoa, chia, canihua, cumin and flax seed, germinating the seed blend prior to inoculating the mycelium starter, and conducting the mushroom cultivation with ORP enhanced water and particular transmissions of sound and particularly colored light. Mushrooms grown by such a method not only mature in 13-15 days rather than 21 days, but have an enhanced nutritional and medicinal profile along with absence of unwanted organism contaminants whose unwanted overgrowth occurs during days 16-21 (or days 16-28) of typical mushroom culture. 1. A method of improving the growth and constitution of edible mushrooms , comprising the steps of blending a seed-based growth substrate containing between 3 and 8 seeds selected from the group consisting of corn , quinoa , canihua , chia , cumin , flax seed and rice , moistening said seed blend with enhanced ORP water , germinating said seed-based growth substrate for between 18 and 48 hours prior to inoculating mycelium starter on said growth substrate and growing the resulting mushrooms for 13-15 days in the presence of one or more of the sound frequencies selected from the group consisting of 396 Hz , 417 Hz , 444 Hz , 528 Hz , 639 Hz , 741 Hz and 852 Hz and also in the presence of transmission of colored light.2. The method of claim 1 , wherein said seed-based growth substrate contains one or more red claim 1 , purple or black colored seeds.3. The method of claim 1 , wherein said seed-based growth substrate contains at least red canihua claim 1 , red flax seed and black chia.4. The method of claim 1 , wherein said seed-based growth substrate contains at least three of purple corn claim 1 , black quinoa claim 1 , red quinoa claim 1 , red canihua claim 1 , black chia claim 1 , black cumin claim 1 , red flax seed claim 1 , and purple rice.5. The method of claim 1 , where said seed-based growth substrate ...

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Номер записи: 7
06-01-2022 дата публикации

PROCESS FOR PRESERVING THE HUSK AND USE OF RAMBUTAN (NEPHELIUM LAPPACEUM) IN FOOD PRODUCTS

Номер: US20220000960A1
Автор: Rojas Hider
Принадлежит: Rambuhealth Corp.

A formulation for delivering one or more health benefits to a human post-consumption and a method to create the formulation are described. The formulation comprises a shell extract of in a form of a powder or a liquid and at least one material. The at least one material comprises a polysaccharide, a protein, a lipid, and/or a food grade compound. The one or more health benefits to the human include support or regulation of blood sugar, blood pressure, body weight, performance/recovery from sports, immune health, anti-aging, pain management, and/or joint health. 1Nephelium lappaceum. A method to maintain a freshness of a shell of , the method comprising:{'i': 'Nephelium lappaceum', 'washing the shell of the with a first solution;'}{'i': 'Nephelium lappaceum', 'washing the shell of the with a component;'}{'i': Nephelium lappaceum', 'Nephelium, 'separating the shell of the from the lappaceum;'}{'i': 'Nephelium', 'packaging the shell of the lappaceum;'}{'i': 'Nephelium lappaceum', 'utilizing a means to decrease an enzymatic activity and a microbial activity of the packaged shell of the ; and'}{'i': 'Nephelium', 'storing the packaged shell of the lappaceum.'}2. The method of claim 1 , wherein the first solution is a neutral soapy solution.3. The method of claim 1 , wherein the component is selected from the group consisting of: a 100 parts per million chlorine solution claim 1 , quaternary ammonium compounds claim 1 , acetic acid claim 1 , peracetic acid claim 1 , and other non-toxic disinfectant.4Nephelium lappaceum. The method of claim 1 , wherein the packaging of the shell of the comprises vacuum packaging.5Nephelium lappaceum. The method of claim 1 , wherein the means to decrease the enzymatic activity and the microbial activity of the packaged shell of the comprises freeze shocking with air claim 1 , pressurized carbon dioxide claim 1 , or liquid nitrogen.6Nephelium lappaceum. The method of claim 1 , wherein the storing of the packaged shell of the occurs at a ...

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Номер записи: 8
03-01-2019 дата публикации

METHOD FOR PRODUCING EXTRACTS CONTAINING HYDROXYCINNAMIC COMPOUNDS FROM VEGETABLE WASTE PRODUCTS

Номер: US20190000787A1
Автор: NOVEJARQUE CONDE José Antonio, PONS RAGA José Vicente
Принадлежит: HIDROXICINAMICS, S.L.

The invention relates to a method for producing an extract containing hydroxycinnamic acids, characterised in that the method uses one or more vegetable waste products from the production of vegetable food products as a raw material, and comprising the following steps: a) selecting at least one waste product from at least one specific vegetable; b) extracting the hydroxycinnamic acids present in the waste product; c) separating the main liquid phase containing the extracted compounds from the solids; d) clarifying the liquid phase produced in step c); and e) concentrating the clarified liquid phase. The invention also relates to the extract produced via this production method, and the formulations containing this extract. 1. A method for producing an extract comprising hydroxycinnamic acids , characterized in that the method uses as raw material one or more plant wastes from the production of plant-based food products , and comprises:a) selecting at least one waste product from at least one plant species,b) extracting the hydroxycinnamic acids present in the waste by means of a technique selected from the group consisting of washing, decoction, maceration, percolation and a combination of any of the above,c) separating the main liquid phase which comprises the compounds extracted from the solids with a size greater than 2 mm,d) clarifying the liquid phase obtained in stage c), ande) concentrating the clarified liquid phase.2. The method for producing an extract according to claim 1 , wherein the plant waste used as raw material comes from the industrial processing or use of plant-based products.3. The method for producing an extract according to claim 2 , wherein the plant waste used as raw material is selected from the group consisting of skins claim 2 , leaves claim 2 , stalks claim 2 , bracts claim 2 , pulp claim 2 , packagings and rejected product.4Cynara scolymusSolanum melongenaCoffea arabicaAristotelia chilensisPunica granatumMangifera indicaNicotiana tabacum ...

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Номер записи: 9
04-01-2018 дата публикации

FORMULATION FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS

Номер: US20180000776A1
Автор: ADHIKARY Sulekha, Ahmad Naseer, Choudhary Dharmendra, Dev Kapil, Kumar Sudhir, Maurya Rakesh, MISHRA Prabhat Ranjan, Mittapelly Naresh, Trivedi Ritu
Принадлежит:

The present invention relates to a formulation of useful for the prevention or treatment of osteo-health related disorders. The present invention relates to the field of pharmaceutical formulation that provides extract, fractions, pure compound isolated from natural sources and formulation thereof useful for the prevention and treatment of various medical indications. Further, this invention relates to conditions associated with estrogen dependent or independent diseases (primary/secondary osteoporosis) or syndromes or disorders preferably relating to cartilage such as osteoarthritis caused in humans and animals. Furthermore, this invention relates to achievement of peak bone mass during skeletal growth and health in humans and animals. Particularly, the present invention relates to the processes for the preparation of biologically active extracts, from from the family Amaranthaceae their pharmaceutically acceptable excepients and compositions of the principal aspect of the present invention. 2Spinacea oleracea.. The formulation as claimed in claim 1 , wherein the spinach is3. The formulation as claimed in claim 1 , wherein the fraction and/or extract comprises claim 1 , solvents selected from the group consisting of ethanol claim 1 , butanol claim 1 , ethyl acetate claim 1 , hexane claim 1 , carbon dioxide or mixture thereof.4. The formulation as claimed in claim 1 , wherein the formulation is a nanoemulsion preconcentrate (SMEDDS).5. The formulation as claimed in claim 1 , wherein the pharmaceutically acceptable carrier is selected from the group consisting of oleic acid claim 1 , castor oil claim 1 , Tween 40 claim 1 , Tween 60 claim 1 , Tween 80 claim 1 , Span 40 claim 1 , Span 60 claim 1 , PEG 400 claim 1 , PEG 600 claim 1 , Propylene Glycoland Ethanol.6. The formulation as claimed in claim 1 , wherein pharmaceutically acceptable additives is selected from the group consisting of microcrystalline cellulose claim 1 , crospovidone claim 1 , cross-linked povidone ...

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Номер записи: 10
02-01-2020 дата публикации

PROCESS FOR EXTRACTING THE ALKALOID FRACTION OF RHODOPHIALA BIFIDA (HERB.) TRAUB AND USES THEREOF

Номер: US20200000798A1
Автор: FARINON Mirian, GNIESLAW DE OLIVEIRA Patricia, PEREIRA RAMOS PEDRAZZA Graziele, RICARDO MACHADO Xavier, SILVEIRA ZUANAZZI José Angelo, SPIES Fernanda
Принадлежит:

The present invention describes a method for completely extracting the alkaloid fraction (montanine) of (Herb.) Traub from bulbs of The present invention further describes a method for treating inflammation using pharmaceutical compositions containing the alkaloid fraction of as the active ingredient. The present invention therefore comprises an extraction method that is faster than other extraction methods described in the literature for the alkaloid fraction of dispensing with numerous changes of solvent in order to strain the plant, and the use thereof as an anti-inflammatory. The present invention is further characterised by the development of an anti-inflammatory medicinal drug for treating and preventing diseases involving inflammation and/or the local increase in the number of fibroblasts as its etiopathogenesis, such as: rheumatoid arthritis, ulcerative colitis, sepsis, acute pulmonary disease, inflammatory infections, in particular inflammatory and fibrosing diseases related to the lungs and kidneys, osteoporosis, Castleman disease, psoriatic arthritis, juvenile chronic arthritis and other non-specific inflammatory joint diseases. 14-. (canceled)5. A method of treating a disease having inflammation and/or localized increase of fibroblasts activity as etiopathogenesis , comprising administering an effective amount of montanine to an individual in need thereof.6. The method of claim 5 , wherein the disease is chosen from Rheumatoid Arthritis claim 5 , juvenile rheumatoid arthritis claim 5 , and osteoporosis.7. The method of claim 5 , wherein the disease is chosen from Castleman's disease claim 5 , psoriatic arthritis claim 5 , and non-specific acute and chronic arthritis.8. The method of claim 5 , wherein the disease is chosen from fibrotic diseases related to the lungs and kidneys.9. The method of claim 5 , wherein the administering does not impact or depress the individual's immune system.10. The method of claim 5 , wherein the treating is for a disease ...

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Номер записи: 11
07-01-2021 дата публикации

COMPOSITION HAVING ERYTHROPOIETIN-INDUCING ACTIVITY, AND METHOD FOR PRODUCING SAME

Номер: US20210000898A1
Автор: KOBAYASHI Fumio, SAITO Masayoshi
Принадлежит:

A composition that has an erythropoietin-inducing activity and can be used as a drug or a food or a beverage is produced by using a culture of or an extract from the culture. In one example of the method for producing such a composition, solid medium containing a protein and a grain is used. In another example of the method, liquid medium containing glucose, yeast extract, rice bran (KOMENUKA), sake lees, soybean powder, sodium aspartate, an inorganic substance and water is used. This composition can be used for the prevention or treatment of anemia. 1Cordyceps militalis. A drug composition for inducing erythropoietin or for prevention or treatment of renal anemia activity comprising culture of or an extract from the culture.2Cordyceps militalis. The drug composition according to claim 1 , wherein the culture of is culture of mycelia.3Cordyceps militalis. The drug composition according to claim 1 , wherein the culture of comprises culture that has been cultured by using solid medium.413.-. (canceled)14Cordyceps militalis. A food or beverage composition for inducing erythropoietin or for prevention of renal anemia comprising culture of or an extract from the culture.15Cordyceps militalis. The food or beverage composition according to claim 14 , wherein the culture of is culture of mycelia.16Cordyceps militalis. The food or beverage composition according to claim 14 , wherein the culture of comprises culture that has been cultured by using solid medium.17Cordyceps militalisCordyceps militalis. A method for producing the drug composition of claim 14 , or the food or beverage composition of claim 14 , comprising step (I) and step (II) claim 14 , wherein the step (I) comprises inoculating spawn of to solid medium comprising a protein and a grain and culturing mycelia claim 14 , and the step (II) comprises obtaining an extract comprising a component that has an erythropoietin-inducing activity from solid culture of that has been obtained through the step (I).18. The ...

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Номер записи: 12
04-01-2018 дата публикации

METHOD OF TREATING ISCHEMIC HEART DISEASE

Номер: US20180000883A1
Автор: ABDUL-HADY SEHAM AL SAYED, AL-JAOUNI SOAD KHALIL, EL-BASSOSSY HANY MOHAMED ABD EL-MALIK, HAGRAS MAGDA MOHAMED, SALAH Numan Abdullah
Принадлежит:

A method of treating ischemic heart disease can include administering a therapeutically effective amount of a composition including date seed nanoparticles to a subject in need thereof. Exemplary suitable dosage forms can include tablet, gel, paste, and suspension. The therapeutically effective amount of the composition including date seed nanoparticles can be about mg/kg to about mg/kg. 1. A method of treating ischemic heart disease comprising administering a therapeutically effective amount of a composition including date seed nanoparticles to a subject in need thereof.2. The method of treating ischemic heart disease according to claim 1 , wherein the date seed nanoparticles are derived from the seed of an Ajwa date.3. The method of treating ischemic heart disease according to claim 1 , wherein the composition further includes the fruit of an Ajwa date.4. The method of treating ischemic heart disease according to claim 3 , wherein the therapeutically effective amount of the date palm composition is about 2 mg/kg to about 2.5 mg/kg.5. The method of treating ischemic heart disease according to claim 1 , wherein the composition further includes a pharmaceutically acceptable carrier.6. A method of preparing nanoparticles of date palm seeds comprising:providing dry date seeds;grinding the dry date seeds to form seed powder; andmilling the seed powder in a planetary ball mill at ambient temperature and pressure to produce date palm seed nanoparticles.7. The method of preparing nanoparticles of date palm seeds according to claim 6 , wherein the planetary ball mill oscillates at about 25 Hz.8. The method of preparing nanoparticles of date palm seeds according to claim 6 , wherein a ratio of steel balls in the planetary ball mill to the seed powder is about 15:1 by weight.9. The method of preparing nanoparticles of date palm seeds according to claim 8 , wherein said steel balls have a diameter of about 15 mm and weight of about 32 g.10. The method of preparing ...

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Номер записи: 13
07-01-2021 дата публикации

METHOD FOR OBTAINING AN EXTRACT ENRICHED IN ROSMARINIC ACID FROM FRESH PLANT MATERIAL

Номер: US20210000901A1
Автор: Humbert Marina, Lavoine Sophie, Meneuvrier Michel, Ughetto Thomas
Принадлежит:

Methods for obtaining an extract enriched in rosmarinic acid from fresh plant material selected from the fresh aerial parts, flowering tops, flowers and/or leaves of plants from the family Lamiaceae, Araliaceae, Boraginaceae, Apiaceae, Poaceae and Malvaceae. The methods include steam bleaching the plant material followed by continuous expression with at least one compression screw, under pressure of between 4 and 10 bar from which the sap (liquid co-product) is recovered. Then, the sap is filtered to produce a clarified sap and is subsequently atomized to obtain a granulated or finely powdered extract containing at least 5% of rosmarinic acid in weight relative to the total weight of the extract. Compositions having such an extract as an active agent are disclosed. The compositions are used in the food, cosmetic, nutraceutical and pharmaceutical fields. 1. A method for obtaining an extract enriched in rosmarinic acid from fresh plant material selected from the fresh aerial parts , flowering tops , flowers and/or leaves of plants from the family Lamiaceae , the method comprising:1) steam bleaching said plant material for less than 2 hours at atmospheric pressure at a temperature of 100° C.;2) continuous expressing with at least one compression screw, under pressure between 4 and 10 bar, of the plant material bleached in 1) with recovery of the sap;3) filtering the recovered sap in 2) to produce a clarified sap; and4) atomizing the clarified sap to obtain a granulated or finely powdered extract containing at least 5% of rosmarinic acid in weight relative to the total weight of the extract.2. (canceled)3. (canceled)4SalviaRosmarinus officinalisOriganum vulgareMentha piperitaSatureja hortensisMelissa officinalis. The method according to claim 1 , wherein the plant material is selected from sage (ssp) claim 1 , rosemary () claim 1 , oregano () claim 1 , mint () claim 1 , summer savory (L.) claim 1 , and lemon balm (L.).5. (canceled)6. The method according to claim 1 , ...

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Номер записи: 14
02-01-2020 дата публикации

METHOD OF PROCESSING CANNABIS PLANT MATTER

Номер: US20200000863A1
Автор: Kennedy Matthew, Millikin Rory Chesley Patrick
Принадлежит:

A method of processing plant matter is provided. It is a particular aspect of the invention to utilize waste from the processing methods and in a sense recycle and use the byproducts to create additional products. The method describes harvesting plant matter at a predetermined time, processing the plant matter to create juice and pulp, and utilizing the pulp to create additional products. This eliminates the waste from processing plant matter solving a potential crisis in the fact that plant matter having cannabinoids leech into the soil and water table from disposal. 1cannabis. A method of processing , comprising steps:{'i': cannabis', 'cannabis, '(a) harvesting plant matter at a predetermined time, wherein the harvesting creates processing waste;'}{'i': 'cannabis', '(b) drying the processing waste; and,'}{'i': 'cannabis', '(c) processing waste to create a powder.'}2cannabis. The method of claim 1 , further comprising a step (d) processing the powder into pill form.3cannabis. The method of claim 1 , wherein in step (b) claim 1 , the processing waste is washed and rinsed.4cannabis. The method of claim 1 , further comprising a step wherein the processing waste is blanched.5cannabis. A method of processing claim 1 , comprising steps:{'i': 'cannabis', '(a) harvesting plant matter in the vegetative stage;'}{'i': 'cannabis', '(b) washing and rinsing the plant matter;'}{'i': 'cannabis', '(c) grinding the plant matter;'}{'i': cannabis', 'cannabis', 'cannabis', 'cannabis, '(d) juicing the ground plant matter via a juicer, wherein the ground plant matter is separated into juice and pulp;'}{'i': 'cannabis', '(e) collecting the juice for consumption;'}{'i': 'cannabis', '(f) drying the pulp; and,'}{'i': cannabis', 'cannabis, '(g) processing the pulp to create a powder.'}6cannabis. The method of claim 5 , further comprising a step (h) processing the powder into pill form.7cannabis. The method of claim 5 , further comprising a step wherein the plant matter is blanched.8. The ...

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Номер записи: 15
03-01-2019 дата публикации

PASSION FLOWER SEED EXTRACT, AND COSMETIC, PHARMACEUTICAL OR DERMATOLOGICAL COMPOSITIONS CONTAINING SAME

Номер: US20190000902A1
Автор: BREDIF Stephanie, Leclere-Bienfait Sophie
Принадлежит: LABORATOIRES EXPANSCIENCE

The invention relates to a polyphenolic extract of passion flower seeds, in particular or seeds, comprising at least 30 percent by weight polyphenols, expressed as gallic acid equivalent, relative to the weight of the dry extract. The invention also relates to a method for preparing an extract of said type, a composition containing same, and the cosmetic, dermatological or therapeutic use thereof. 112-. (canceled)13Passiflora incarnataPassiflora edulis. A polyphenolic extract of seeds of passion flower , in particular of or , comprising at least 30 wt % polyphenols , expressed as gallic acid equivalents , relative to the weight of the dry extract , and at least 10 wt % organic acids , relative to the weight of the dry extract.14. The extract of claim 13 , comprising at least 35 wt % polyphenols claim 13 , expressed as gallic acid equivalents claim 13 , relative to the weight of the dry extract.15. The extract of claim 13 , wherein at least 50 wt % of said polyphenols are catechin derivatives claim 13 , expressed as gallic acid equivalents claim 13 , relative to the weight of polyphenols in the dry extract.16. The extract of claim 13 , wherein said organic acids are acetic acid claim 13 , malic acid claim 13 , citric acid or mixtures thereof.17. The extract of claim 13 , characterized in that it is obtained by solid/liquid extraction of passion flower seeds in a solvent selected from water claim 13 , glycerols claim 13 , glycols claim 13 , and mixtures thereof.18. The extract of claim 13 , characterized in that it is obtained by solid/liquid extraction of passion flower seeds in a solvent selected from the binary mixtures water/glycerol claim 13 , water/glycol claim 13 , and mixtures thereof.19. A method for preparing a polyphenolic extract of passion flower seeds as defined in claim 13 , said method comprising at least one step of solid/liquid extraction in a solvent selected from water claim 13 , glycerols claim 13 , glycols claim 13 , and mixtures thereof.20. The ...

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Номер записи: 16
03-01-2019 дата публикации

Gynostemma pentaphyllum fermented extracts comprising Saponins as an active functional food ingredient and preparation method thereof

Номер: US20190000905A1
Автор: KIM Tea Young, KU Myoung Seo, MOON Joo-Myung
Принадлежит:

A method for preparing an extract of fermented with increased contents of saponins or low-molecular-weight saponins, which includes a step of preparing a fermentation product by fermenting with a microorganism selected from and ; and a step of extracting the fermentation product with hot water. 1Gynostemma pentaphyllum. A method for preparing an extract of fermented with increased contents of saponins or low-molecular-weight saponins , which comprises:{'i': Gynostemma pentaphyllum', 'Gynostemma pentaphyllum', 'Aspergillus oryzae, Aspergillus awamori, Aspergillus kawachii, Lactobacillus brevis', 'Lactobacillus plantarum, '(1) a step of preparing a fermentation product by fermenting with a microorganism selected from and ; and'}{'i': 'Gynostemma pentaphyllum', '(2) a step of extracting the fermentation product with hot water.'}2Gynostemma pentaphyllum. The method for preparing an extract of fermented according to claim 1 , wherein the saponin is one or more selected from dammarane-type saponin claim 1 , gynosaponin claim 1 , ginsenoside claim 1 , primeveroside claim 1 , sweroside claim 1 , bisdesmoside claim 1 , gentiobioside and rutinoside.3Gynostemma pentaphyllum. The method for preparing an extract of fermented according to claim 1 , wherein the low-molecular-weight saponin is one or more selected from Rg3 claim 1 , Rg5 claim 1 , Rk1 claim 1 , Rh2 claim 1 , gypenoside L and gypenoside LI.4Gynostemma pentaphyllum. The method for preparing an extract of fermented according to claim 1 , wherein the fermentation is performed at 25-45° C. for 6-240 hours.5Gynostemma pentaphyllum. The method for preparing an extract of fermented according to claim 1 , which further comprises:{'i': Gynostemma pentaphyllum', 'Gynostemma pentaphyllum', 'Gynostemma pentaphyllum, 'a step of preparing an extract of fermented pomace by extracting fermented pomace, which is a hot water-extracted fermentation product, with water or a 20-70% C1-4 alcohol aqueous solution at 30-130° C.; and'}{'i': ...

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Номер записи: 17
03-01-2019 дата публикации

METHODS OF TREATING DISEASES USING GRAPE PROTEINS

Номер: US20190000910A1
Автор: Hoang Kieu
Принадлежит:

A food composition for human consumption comprising a plurality of grape ingredients, wherein the plurality of grape ingredients comprise ground flesh, seed, stem, and skin from grapes, and wherein the plurality of grape ingredients further comprise one or more KH Grape proteins. A method of treating a certain disease in a patient comprising administering the food composition to a patient in need thereof, wherein the food composition has a concentration of KH Grape protein above 0%. 1. A food composition for human consumption comprising:a plurality of grape ingredients,wherein the plurality of grape ingredients comprise ground flesh, seed, stem, and skin from grapes, andwherein the plurality of grape ingredients further comprise one or more KH Grape proteins.2. The food composition of claim 1 , wherein the food composition is a powder claim 1 , juice or other beverage claim 1 , food supplement claim 1 , or concentrate.3. The food composition of claim 2 , wherein the food composition is a beverage and the KH Grape protein comprises KH103 protein.4. The food composition of claim 1 , wherein the KH Grape protein comprises KHJ protein.5. The food composition of claim 4 , wherein the KHJ protein comprises proteins having a molecular weight similar to molecular weights of human immunoglobulin and APOA-1 proteins.6. The food composition of claim 4 , further comprising living cells.7. The food composition of claim 1 , wherein the KH Grape protein comprises KH602 protein.8. The food composition of claim 1 , wherein the KH Grape protein comprises a combination of KH103 protein and KHJ protein.9. The food composition of claim 8 , wherein the food composition is in liquid or powder form.10. A method of treating a certain disease in a patient comprising administering the food composition of to a patient in need thereof claim 1 , wherein the food composition has a concentration of KH Grape protein above 0%.11. The method of claim 10 , wherein the certain disease is cancer and the ...

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Номер записи: 18
03-01-2019 дата публикации

HERBAL COMPOSITION FOR HEALING OF WOUND, CUTS AND BURNS AND A METHOD OF SYNTHESIZING THEREOF

Номер: US20190000911A1
Автор: Sepahvand Fariba
Принадлежит:

The embodiments herein disclose a method for synthesizing an ointment from water plantain for the wounds, cuts and burnt tissues. The water plantain plant sample is collected and subjected for botanical analysis. The water plantain plant sample are pre-treated and dried. The dried water plantain plant samples are grinded to a powder. The water plantain plant powder is subjected to maceration/soaking for obtaining hydroalcoholic extract. A total of 5 litres of hydroalcoholic solvent extract comprising the essential nutrients and components of water plantain plant is obtained. A predetermined amount of the hydroalcoholic solvent extract is condensed in a rotary evaporator. The water plantain plant powder and hydroalcoholic solvent extract are tested for blood clotting. The hydroalcoholic solvent extract is mixed with Vaseline to obtain an ointment. The ointment is tested on rat wounds to find that the wound is healed in 15 days. 1. A method for extracting the hydro alcoholic solvent extract comprising nutrients and components of water plantain plant for synthesizing an ointment for application on wounds , cuts and burnt tissues , the method comprises the steps of:pre-treating a plurality of water plantain plant samples;cleaning and dis-infecting the plurality of water plantain plant samples;drying the plurality of cleaned and disinfected water plantain plant samples in open air and in normal atmospheric conditions, and wherein the plurality of water plantain plant samples are dried in a shade area or dark room without exposing to any light source;grinding the dried water plantain plant samples to obtain a powder using a grinding machine and a sieve;subjecting the water plantain plant powder for maceration/soaking in a solvent for obtaining hydro alcoholic extract for synthesizing an ointment;condensing a predetermined amount of hydro alcoholic solvent extract by heating in a water bath of a rotary evaporator for a predetermined time period, and wherein the hydro ...

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Номер записи: 19
05-01-2017 дата публикации

CANNABIS PLANT FILTER AND APPARATUS

Номер: US20170001200A1
Автор: Leffel Mitchell
Принадлежит:

An assembly for separating cannabis trichomes by a vibrating platform and at least one filter. 1. An assembly comprising:a platform capable of rapid or repetitive movement, the platform including a base segment to retain cannabis leaves, the platform being operable to subject the cannabis leaves to movement and to distribute trichomes from the cannabis leaves through the base segment; anda filter layer to receive trichomes of a variety of sizes from the base segment when the cannabis leaves are subjected to movement with the platform.2. The assembly of claim 1 , wherein the filter layer includes multiple filters claim 1 , each of the multiple filters having a variety of granularity in order to separate and collect trichomes of different sizes.3. The assembly of claim 2 , wherein the filters of the filter layer include multiple filters which have different size openings from other filters of the filter layer.4. The assembly of claim 3 , wherein the multiple filters include a first filter having openings of about 200 microns claim 3 , a second filter having openings of about 120 microns claim 3 , and a third filter having openings of about 60 microns.5. The assembly of claim 1 , wherein each filter is individually laterally removable from the assembly.6. The assembly of claim 1 , further comprising a cutting device positioned above the platform to separate a cannabis plant.7. The assembly of claim 6 , further comprising a stainless steel housing at least partially encompassing the cutting device.8. The assembly of claim 7 , further comprising a power source positioned on an exterior of the housing.9. The assembly of claim 7 , further comprising a removable lid to access the cutting device.10. The assembly of claim 6 , wherein the platform comprises a movable drawer in which the filters are stacked.11. A cutting assembly for separating a cannabis plant claim 6 , comprising:a rotating drum, the drum comprising a plurality of cutting implements to remove leaves from the ...

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Номер записи: 20
12-01-2017 дата публикации

COMPOSITION AND METHOD TO ALLEVIATE JOINT PAIN USING PHOSPHOLIPIDS AND ASTAXANTHIN

Номер: US20170007555A1
Автор: Hill W. Stephen, MINATELLI John A., Moerck Rudi E.
Принадлежит:

A dietary supplement composition and associated method of use has the composition formulated in a therapeutic amount to treat and alleviate symptoms of joint pain in a person having joint pain. The composition includes astaxanthin and microbial fermented, low molecular weight hyaluronic acid or sodium hyaluronate (hyaluronan). The composition also includes at least one of a phospholipid, glycolipid, and sphingolipid. It is formulated into an oral dosage form and the astaxanthin is 0.1 to 15 percent by weight of the at least one phospholipid, glycolipid, and sphingolipid. 1. A method to treat and alleviate symptoms of joint pain by administering to a person having joint pain a therapeutic amount of a dietary supplement composition , including astaxanthin , pro-inflammatory low molecular weight microbial fermented sodium hyaluronate fragments having a molecular weight of 0.5 to 300 kilodaltons (kDa) , and a marine or seed oil and including a lipid selected from the group consisting of a phospholipid , glycolipid , and sphingolipid , and formulated into an oral dosage form , wherein the astaxanthin is 0.1 to 15 percent by weight of the marine or seed oil and the lipid selected from the group consisting of the phospholipid , glycolipid and sphingolipid.2. The method according to claim 1 , wherein the astaxanthin comprises a natural or synthetic ester or synthetic diol derivative.3. The method according to claim 1 , further comprising adding a pharmaceutical or food grade diluent to the marine or seed oil and the lipid selected from the group consisting of the phospholipid claim 1 , glycolipid and sphingolipid.4. The method according to claim 1 , wherein the phospholipid is selected from the group consisting of Phosphatidylcholine claim 1 , Phosphatidylethanolamine claim 1 , Phosphatidylserine claim 1 , Phosphatidylinositol claim 1 , Phosphatidic acid claim 1 , Lyso-Phosphatidylcholine claim 1 , Lyso-Phosphatidylethanolamine claim 1 , and Lyso-Phosphatidylserine.5. The ...

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Номер записи: 21
12-01-2017 дата публикации

GREEN COFFEE BEAN EXTRACT AND METHOD THEREOF

Номер: US20170007658A1
Автор: Sharma Ashok, Tewari Kiran, Uppal Dalip
Принадлежит:

An extract from green coffee beans is disclosed which contains polyphenols and bioactive compounds e.g. Chlorogenic acids in a significantly higher concentration (70-80%) than in extracts of prior art methods (40-50%). The extract has greater ability to quench oxidative stress and destroy free radicals and offers health benefits due to its anti-obesity, anti-diabetic, antihypertensive, anti-tumor and anti-acid properties. The higher concentration of bioactive compounds has been achieved by use of polar solvents having polarity less than that of alcohols used for extraction. The use of such solvents of lower polarity such as n-Butyl alcohol, ethyl acetate or acetone results in extraction of enriched Chlorogenic acid fractions into the extract, leaving polar impurities behind in aqueous medium. The extract obtained has significantly higher content of polyphenols and chlorogenic acids ranging from 70-80% and a distinctive HPLC profile. 16-. (canceled)7. A method to produce an enriched extract having chlorogenic acids content ranging between 70-80% , from dried coffee beans , wherein the method comprises the steps of:i. powdering the dried coffee beans;ii. adding water in equal quantity and stirring at a temperature between 45-550 Celsius for 4 hours;iii. adding the polar solvent ethyl acetate, which has polarity lower than that of alcohols, in quantity four times the quantity of raw material and stirring at 50-55° Celsius till extraction is completed;iv. separating and drying the solvent layer to obtain a dry mass which is then purified by dissolving in water and washing with chlorinated solvents such as chloroform or methylene chloride to remove caffeine; andv. evaporating the water to obtain the dry powder extract in which the content of chlorogenic acids ranges between 70-80%.8. A method to produce an enriched extract having chlorogenic acids content ranging between 70-80% , from dried coffee beans , wherein the method comprises the steps of:i. powdering the source ...

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Номер записи: 22
11-01-2018 дата публикации

ACTIVE SUBSTANCE FOR PREVENTING DEGENERATION OF HEARING, COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREOF

Номер: US20180007836A1
Автор: Chan Yin-Ching, CHEN Chin-Chu, Chen Wan-Ping, Lee Li-Ya
Принадлежит: GRAPE KING BIO LTD.

The present invention discloses the active substances for preventing hearing deterioration, its preparation method, the pharmaceutical composition containing the active substances, and the preparation method of the pharmaceutical composition. The preparation method of the active substances is performed by plate cultivation, flask cultivation and fermentation tank cultivation, to obtain the active substances of mycelia in powder form. The powder of mycelia is proved to have the effect of preventing hearing deterioration. 113.-. (canceled)14Hericium erinaceus. A pharmaceutical composition for preventing a hearing deterioration , comprising an active substance of a , and one selected from the group consisting of a biologically acceptable carrier , an excipient , a diluent and an adjuvant , wherein the active substance is prepared by a method comprising:{'i': 'H. erinaceus', '(a) inoculating an mycelium on an agar plate to be incubated;'}(b) inoculating the incubated mycelium in step (a) into a first medium on a small scale to be incubated; and(c) inoculating the incubated mycelium in step (b) into a second medium on a large scale to be incubated to obtain a fermented medium containing the active substance.15. The pharmaceutical composition according to claim 14 , wherein the incubation in step (a) is performed at 15-32° C. for 8-16 days.16. The pharmaceutical composition according to claim 14 , wherein the incubation in step (b) is performed at 20-30° C. claim 14 , pH 4.5-6.5 claim 14 , and a shaking rate of 100-250 rounds per minutes (rpm) for 3-5 days.17. The pharmaceutical composition according to claim 14 , wherein in step (c) claim 14 , the second medium on the large scale is accommodated in a fermentation tank having a tank pressure of 0.8-1.2 kg/cmand a stirring rate of 10-150 rpm claim 14 , and a gas is introduced into the fermentation tank at an aeration rate of 0.5-1 volume per volume per minute (vvm).18. The pharmaceutical composition according to claim 17 , ...

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Номер записи: 23
11-01-2018 дата публикации

METHODS OF TREATMENT USING PURIFIED (DECOLORIZED) ALOE VERA LEAF DRY JUICE

Номер: US20180008661A1
Автор: Bertocco Andrea, LI Wenjie, Park Joosang, Yatcilla Michael
Принадлежит:

Disclosed herein is a method for improving the health of animal or human microflora using aloe vera. A method of purifying decolorized dried aloe vera leaf juice is also disclosed. The method may include removing an aloe vera leaf from an aloe vera plant, washing and/or sanitizing the leaf, and grinding the leaf into a slurry and subsequently purifying with activated carbon. The method may remove pigmented substances including the undesirable phenolic compounds present in aloe vera latex, and in particular the anthrones aloin A and aloin B, aloesin (a chromone) and aloe-emodin (an anthraquinone). Following purification, the liquid juice may then be spray-dried to form a final dry juice powder. 1. A method for inducing a beneficial effect on the human microbiome , the method comprising administering a composition to a mammal , the composition comprising decolorized aloe vera juice , aloe vera concentrate and one or more excipients.2. The method of claim 1 , wherein the beneficial effect on the human microbiome is selected from the group consisting of an increased production of short chain fatty acids claim 1 , an increased total microbial population in the colon claim 1 , an increased production of acetate in the proximal colon claim 1 , an increased production of propionate in the proximal colon claim 1 , an increased population of the total bacteria in the proximal colon claim 1 , an increased population of the transient concentration of bifidobacteria in the proximal colon claim 1 , a strong anti-inflammatory response in the intestine claim 1 , a decreased gut-barrier permeability in a co-culture system of Coca-2 cells and THP1 macrophages claim 1 , and a gut soothing effect.3. The method of claim 2 , wherein gut permeability is measured by paracellular transport of Lucifer Yellow in a co-culture system of Caco-2 cells and THP1 macrophages.4. A method for improving health and quantity of the microbiome or inducing a beneficial effect in a mammal claim 2 , the ...

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Номер записи: 24
11-01-2018 дата публикации

COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING PULMONARY HYPERTENSION

Номер: US20180008662A1
Автор: LE MYPHUONG T., VILLEGAS LEAH R.
Принадлежит:

The present invention provides a method of treating and/or preventing pulmonary hypertension in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a bioactive peptide preparation derived from at least one botanical source. 1Rosa damascena, Juglans nigra, Syzygium aromaticum, Inonotus obliquus, Camellia sinensis, Hypericum perforatum, Forsythia suspensa, Scutellaria laterifloraVerbena hastata.. A method of treating or preventing pulmonary hypertension in a subject , the method comprising administering to the subject in need thereof a therapeutically effective amount of a bioactive peptide preparation comprising an extract from at least one plant species selected from the group consisting of , and2. The method of claim 1 , wherein the preparation inhibits or scavenges reactive oxygen species in the subject.3. The method of claim 1 , wherein the preparation treats or alleviates one or more pulmonary hypertension symptoms selected from the group consisting of shortness of breath claim 1 , fatigue claim 1 , chest pressure claim 1 , chest pain claim 1 , abdominal pain claim 1 , racing pulse claim 1 , heart palpitations claim 1 , poor appetite claim 1 , nausea claim 1 , lightheadedness claim 1 , fainting claim 1 , dizziness claim 1 , swelling claim 1 , cyanosis claim 1 , abnormal blood pressure claim 1 , and chronic cough.4. The method of claim 1 , wherein the preparation comprises a plant species extract that is insoluble in at least one solvent selected from the group consisting of trichloroacetic acid claim 1 , acetone claim 1 , methanol claim 1 , an ammonium acetate solution claim 1 , and any combinations thereof.5. The method of claim 1 , wherein the preparation comprises a plant species extract that is soluble in at least one selected from the group consisting of phenol and sodium dodecyl sulfate (SDS).6. The method of claim 1 , wherein the preparation comprises a plant extract produced through a ...

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Номер записи: 25
14-01-2021 дата публикации

PREPARATION AND USES OF SPINOSIN-Na FROM ZIZIPHI SPINOSAE SEMEN

Номер: US20210008142A1
Автор: Jia Bin, LI Hanqing, LI Zhuoyu, SHAN Shuhua, SHI Jiangying, SONG Guisheng, XIE Yue
Принадлежит:

Disclosed are a preparation method and applications of a spinosin-Na monomer of Ziziphi Spinosae Semen. The preparation method includes: pulverizing Ziziphi Spinosae Semen; hydrolyzing the powder with an acidic hydrolysis solution; neutralizing the hydrolysate; extracting the supernatant with ethyl acetate several times to produce a crude extract; and separating the crude extract sequentially using macroporous resin and HPLC to produce the spinosin-Na monomer of Ziziphi Spinosae Semen with a good water solubility and a purity greater than 98%. The spinosin-Na monomer prepared herein is capable of significantly inhibiting the proliferation of tumor cells, so that it can be applied in the preparation of a functional food and/or medicine for preventing and/or treating tumors.

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Номер записи: 26
12-01-2017 дата публикации

PROCESSES AND METHODS OF MANUFACTURE OF ARECOLINE

Номер: US20170009264A1
Автор: Balder Edwin
Принадлежит:

Processes and methods of manufacturing an areca fruit product. One process may include the steps of providing a plurality of areca fruits, drying the plurality of areca fruits, dehusking the plurality of areca fruits to obtain a plurality of areca nuts, chopping, shredding or grinding the plurality of areca nuts into a multiplicity of areca nut particles, introducing the multiplicity of areca nut particles into a tank containing water, agitating the multiplicity of areca nut particles to create a slurry, determining an amount of arecoline in the slurry and pumping the water having the predetermined amount of arecoline through a filter and into a holding tank and evaporating the arecoline from the water. Additional steps include fermentation, distillation, pasteurization, and cold pressing of the arecoline to produce a synthetic nicotine and/or botanical pesticide. 1. A process of preparing an areca fruit product , the process comprising the steps of:providing a plurality of areca fruits;drying the plurality of areca fruits;dehusking the plurality of areca fruits to obtain a plurality of areca nuts;chopping, shredding or grinding the plurality of areca nuts into a multiplicity of areca nut particles;introducing the multiplicity of areca nut particles into a tank containing water at a temperature between 40-90° Centigrade;agitating the multiplicity of areca nut particles to create a slurry;determining an amount of arecoline in the slurry;adding additional multiplicities of areca nut particles to the slurry until the slurry contains a predetermined amount of arecoline;pumping the slurry containing the predetermined amount of arecoline through a filter and into a holding tank; andfermenting said slurry containing the predetermined amount of arecoline by adding one or more microorganisms to said slurry.2. The process of claim 1 , further comprising the step of:before said fermenting step, transferring the slurry from the holding tank into an evaporator, concentrating the ...

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Номер записи: 27
27-01-2022 дата публикации

Isolation and characterization of anticancer compound from sesuvium portulacastrum (l.) l.

Номер: US20220024872A1
Автор: Lakshmi Narasu Mangamoori, Sathvika CHINTALAPANI
Принадлежит: Individual

The invention discloses a novel anticancer compound, 3, 4, 5-trimethyl-2-(4-(8-methylnonyl)phenyl)pyridine extracted from Sesuvium portulacastrum (S. portulacastrum) having the structure as represented by Formula (I). The invention also discloses a method of extraction of this anticancer compound, 3, 4, 5-trimethyl-2-(4-(8-methylnonyl)phenyl)pyridine from S. portulacastrum. The invention further relates to characterization of the anticancer compound, 3, 4, 5-trimethyl-2-(4-(8-methylnonyl)phenyl)pyridine and study of its effect on the cancer cell cycle progression and expression of genes involved in apoptosis.

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Номер записи: 28
09-01-2020 дата публикации

METHOD FOR PREPARATION OF PHARMACOLOGICALLY-RELEVANT COMPOUNDS FROM BOTANICAL SOURCES

Номер: US20200009205A1
Автор: RIVAS Jose
Принадлежит:

In a multi-step process for selectively purifying various pharmacologically-relevant components of a source plant such as cannabis, an initial step of the process provides a low-temperature, robust essential oil/terpene capture that also dehydrates and decarboxylates the starting product—fresh raw cannabis—by means of a vacuum-assisted microwave distillation process. By doing the terpene capture under vacuum distillation temperature may be kept low. The low distillation temperature maximizes yields of thermally-sensitive components such as terpenes and cannabinoids. The process includes additional steps of: extract cannabinoids from the dehydrated cannabis to produce a crude extract via a supercritical CO2 extraction process; purify crude extract of fats, lipids, plant material; and distill relevant cannabinoids from the purified crude extract via a wiped-film process. Selected terpenes and cannabinoids are then recombined in predetermined proportions to achieve extracts of unusual purity and having targeted therapeutic profiles. 1. A method for preparing purified extracts from raw cannabis comprising:A. distilling a terpene-rich essential oil from a water/raw cannabis mixture prepared by heating the raw cannabis/water mixture under gravity-assisted, vacuum conditions in a microwave oven at a predetermined power level for a predetermined period of time;B. followed by preparing a cannabinoid-rich crude extract from dried, decarboxylated cannabis resulting from A by exposing the dried, decarboxylated cannabis to a solvent and allowing a resulting extract to accumulate in a collection vessel as the solvent is purged;C. followed by refining the crude extract to remove impurities; andD. followed by preparing a purified extract from the refined extract by distilling the refined extract in a wiped-film evaporator under vacuum conditions.2. The method of claim 1 , further comprising:recombining the terpene-rich essential oil and the purified extract in predetermined ...

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Номер записи: 29
09-01-2020 дата публикации

METHOD FOR PREPARATION OF PHARMACOLOGICALLY-RELEVANT COMPOUNDS FROM BOTANICAL SOURCES

Номер: US20200009206A1
Автор: RIVAS Jose
Принадлежит:

In a multi-step process for selectively purifying various pharmacologically-relevant components of a source plant such as cannabis, an initial step of the process provides a low-temperature, robust essential oil/terpene capture that also dehydrates and decarboxylates the starting—fresh raw cannabis—by means of a vacuum-assisted microwave distillation process. By doing the terpene capture under vacuum distillation temperature may be kept low. The low distillation temperature maximizes yields of thermally-sensitive components such as terpenes and cannabinoids. The process includes additional steps of: extract cannabinoids from the dehydrated cannabis to produce a crude extract via a supercritical CO2 extraction process; purify crude extract of fats, lipids, plant material; and distill relevant cannabinoids from the purified crude extract via a wiped-film process. Selected terpenes and cannabinoids are then recombined in predetermined proportions to achieve extracts of unusual purity and having targeted therapeutic profiles. 1. A method for preparing purified extracts from raw cannabis comprising:A. distilling a terpene-rich essential oil from a water/raw cannabis mixture prepared by heating the raw cannabis/water mixture under gravity-assisted, vacuum conditions in a microwave oven at a predetermined power level for a predetermined period of time;B. followed by preparing a cannabinoid-rich crude extract from dried, decarboxylated cannabis resulting from A by exposing the dried, decarboxylated cannabis to a solvent and allowing a resulting extract to accumulate in a collection vessel as the solvent is purged;C. followed by refining the crude extract to remove impurities; andD. followed by preparing a purified extract from the refined extract by distilling the refined extract in a wiped-film evaporator under vacuum conditions.2. (canceled)3. The method of claim 1 , wherein A further comprises:heating a distillation vessel containing raw cannabis in a microwave oven ...

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Номер записи: 30
11-01-2018 дата публикации

Arginine-rich Peptide Mixture, their Application Thereof in Cervical Cancer Therapy, and a Process for Producing same

Номер: US20180009842A1
Автор: Chen Dongliang, HE Lirong, Liu Lijian, Zhang Yang
Принадлежит:

A process for producing an arginine-rich peptide mixture and the application thereof in cervical cancer therapy is provided. The process includes the following steps: A suspension of walnut meal and egg albumin is pretreated with ultrahigh pressure, and then digested by alkaline proteinase and papain in separated steps with the ultrasonic and microwave-assisted extraction. The peptides of interest are isolated from filtration supernatant obtained after the enzyme digestion by reversed phase high-performance liquid chromatography. By using the peptide mixture as a template, acrylic acid and methyl acrylic acid as functional monomers, triethylene glycol dimethacrylate as cross-linking agent, and isopropylthioxanthone in acetone as a photoinitiator, polymerization is induced by ultraviolet light to form a surface imprinted membrane for isolating and enriching the peptides of interest from the supernatant. The arginine content in the peptide mixture is more than 18%. The arginine-rich peptide mixture is able to strongly suppress the proliferation of human cervical cancer Hela cells. The approach is applicable to reduce the cost of production and speed up the commercialization of large-scale production. 1. A process for producing an arginine-rich peptide mixture , comprising the following steps:(a) collecting a supernatant comprising peptides of interest, wherein de-fatted and pulverized walnut meal, egg albumin and water are mixed and stirred, pretreated with ultrahigh pressure, and subsequently enzymatic digested with ultrasonic-microwave-assisted extraction, wherein enzymes are inactivated by raising temperature and the supernatant is collected through plate and frame pressure filtration; and(b) isolating the peptides of interest from the supernatant, wherein the supernatant is freeze-dried, and the peptides of interest in freeze-dried coarse powder are subsequently isolated by using reversed phase high-performance liquid chromatography (RP-HPLC), wherein Everest C18 ...

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Номер записи: 31
03-02-2022 дата публикации

Phenylethanoid Glycoside Extract from Acanthus Ilicifolius L., Preparation Method thereof and Use as Anti-liver Injury Medicament

Номер: US20220031783A1
Автор: BAI Hong, Ren Xia, SHAO Changlun, Wang Changyun, XIN Lanting, YUE Shijun, ZHANG Mengqi, Zhao Qing
Принадлежит:

Provided are a phenylethanoid glycoside extract from the plant L., a preparation method thereof, and its use as an anti-liver injury medicament. The preparation method of the phenylethanoid glycoside extract comprises following steps: pulverizing dried whole plant L. and passing through 20-30 mesh sieve to obtain L. powder, adding 50%-95% ethanol solution whose mass is 8-20 times of the powder, soaking and extracting under reflux, filtering and collecting extract of the powder, and extracting a filter residue under reflux with 50%-95% ethanol solution whose mass is 8-10 times of the filter residue and collecting extract of the filter residue, combining, concentrating and subjecting to macroporous resin column chromatography, eluting successively by 10%, 30% and 50% ethanol solutions for four column volumes, respectively, collecting fraction eluted by the 50% ethanol solution and drying to obtain the phenylethanoid glycoside extract. 1. A phenylethanoid glycoside extract , wherein the phenylethanoid glycoside extract is prepared by a method comprising following steps:{'i': Acanthus ilicifolius', 'Acanthus ilicifolius, 'pulverizing dried whole plant L. and passing through a 20-30 mesh sieve to obtain L. powder, adding a 50%-95% ethanol solution whose mass is 8-20 times of the powder, soaking for 1-3 h and then extracting under reflux for 2-4 h, filtering and collecting an extract of the powder, and then extracting a filter residue under reflux for 1.5-2 h with 50%-95% ethanol solution whose mass is 8-10 times of the filter residue and collecting an extract of the filter residue, combining the extract of the powder and the extract of the filter residue, concentrating and subjecting to macroporous resin column chromatography, eluting successively by 10%, 30% and 50% ethanol solutions for four column volumes, respectively, collecting a fraction eluted by the 50% ethanol solution and drying to obtain the phenylethanoid glycoside extract, wherein the percentages of ethanol ...

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Номер записи: 32
19-01-2017 дата публикации

METHOD FOR MANUFACTURING ALOE EXTRACT, AND ALOE EXTRACT

Номер: US20170013868A1
Автор: Yuda Naoki
Принадлежит: Morinaga Milk Industry Co., Ltd.

A major object of the present technology is to provide a technology for obtaining an aloe extract which has an excellent processability into foods and contains sufficient amounts of β-sitosterol and aloe-derived dietary fibers as functional components. The present technology provides a method for manufacturing an aloe extract containing β-sitosterol, phospholipids, and dietary fibers which involves carrying out: a homogenization step for homogenizing an aloe mesophyll solution; an enzymatic degradation step for adding a polysaccharide-degrading enzyme to the homogenized aloe mesophyll solution and degrading polysaccharides contained in the aforementioned homogenized aloe mesophyll solution; and a membrane filtration step for membrane-filtering the enzyme-degraded aloe mesophyll solution with a microfiltration membrane or an ultrafiltration membrane and recovering the retentate fraction as an aloe extract. 1. A method for manufacturing an aloe extract containing β-sitosterol , phospholipids , and dietary fibers which involves carrying out:a homogenization step for homogenizing an aloe mesophyll solution;an enzymatic degradation step for adding a polysaccharide-degrading enzyme to the homogenized aloe mesophyll solution and degrading polysaccharides contained in the homogenized aloe mesophyll solution; and,a membrane filtration step for membrane-filtering the enzyme-degraded aloe mesophyll solution with a microfiltration membrane or an ultrafiltration membrane and recovering the retentate fraction as an aloe extract.2. The method for manufacturing an aloe extract according to wherein the enzymatic degradation step is a step for adding 0.01 to 1.0% by mass of the polysaccharide-degrading enzyme based on aloe mesophyll non-volatile components contained in the homogenized aloe mesophyll solution and degrading polysaccharides contained in the aloe mesophyll solution.3. The method for manufacturing an aloe extract according to or wherein the polysaccharide-degrading enzyme ...

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Номер записи: 33
19-01-2017 дата публикации

Composition Comprising Plants Extracts that Synergistically Treat or Inhibit Pathological Conditions and Method of Making

Номер: US20170014463A1
Автор: Nolan Bruce
Принадлежит:

A composition including plant extracts that synergistically treat or inhibit pathological conditions and a method for developing the composition is provided. The composition includes bioactive chemical agents extracted from the plant species including, but not limited to, acetonide, catalpol, hispidulin, loliolide, neptin, rhamnose, and scutellarin, and bioactive chemical agents extracted from the plant species including, but not limited to, cadinol, diosmetin, eugenol, furfural, hesperidin, luteolin, and piperitone. The method includes the steps of washing and plant material, freezing the plant material, cutting the frozen plant material into pieces, heating the plant material in purified water to form a resultant solution containing and plant extracts, cooling the resultant solution, and filtering the and plant material out of the resultant solution to produce the composition. 1Plantago majorMentha spicata) A composition for inhibiting or treating pathological conditions , the composition comprising an effective amount of a plurality of plant extracts from a plant species and an effective amount of plurality of plant extracts from a plant species.2) A composition for inhibiting or treating pathological conditions , the composition comprising an effective amount of a plurality of plant extracts including acetonide , adenine , allantoin , apigenin , apigenin-7-glucoside , asperuloside , aucubin , baicalein , baicalin , benzoic acid , caffeic acid , catalpol , chlorogenic acid , cinnamic acid , D-glucose , D-xylose , ferulic acid , fumaric acid , geniposidic acid , gentisic acid , glucoraphanin , hispidulin , hydroxycinnamic acid , loliolide , luteolin , luteolin-7-O-beta-D-glucoside , neochlorogenic acid , nepetin , oleanolic acid , P-coumaric acid , P-hydroxybenzoic acid , phenolcarbonic acid , rhamnose , saccharose , salicylic acid , scutellarin , sitosterol , succinic acid , sulforaphane , syringic acid , syringin , tyrosol , ursolic acid , vanillic acid , acetic ...

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Номер записи: 34
19-01-2017 дата публикации

HERBAL COMPOSITION FOR BODY TREATMENT

Номер: US20170014464A1
Автор: Rodriguez Fernando Blanco
Принадлежит:

The present invention discloses an herbal composition comprising a therapeutic effective amount of Cascalote () and a therapeutic effective amount of Ruda (). In another implementation, the herbal composition can also comprise of an effective amount of at least one pharmaceutically acceptable excipient for application to the body, including skin and tissue. The disclosed invention also includes a method for making the herbal composition and a method of application of the herbal composition. 1. An herbal composition comprising:a therapeutic effective amount of Cascalote; anda therapeutic effective amount of Ruda.2. The herbal composition of claim 1 , further comprising:an effective amount of at least one pharmaceutically acceptable excipient.3. The herbal composition of claim 1 , wherein a range of therapeutic effective amount of Cascalote is made from 0.25-2 lbs. of Cascalote per one gallon of pharmaceutically acceptable excipient.4. The herbal composition of claim 1 , wherein a range of therapeutic effective amount of Ruda is made from 0.25-2 oz. of Ruda per one gallon of pharmaceutically acceptable excipient.5. The herbal composition of claim 2 , wherein the at least one pharmaceutically acceptable excipient is in a range of 90% to 98% w/w of the total composition of the herbal composition.6. The herbal composition of claim 2 , wherein the pharmaceutically acceptable excipient comprises at least one of astringent claim 2 , antioxidant claim 2 , vaginal conditioning agent claim 2 , vasodillating agent claim 2 , thickening agent claim 2 , preservative claim 2 , lubricating agent claim 2 , colorant claim 2 , and water.7. The herbal composition of claim 2 , wherein the pharmaceutically acceptable excipient may be an orally or topically acceptable carrier and/or an orally or topically acceptable diluent.8. The herbal composition of claim 1 , for the treatment of at least one of skin and tissue.9. The herbal composition of claim 1 , for the treatment of a ...

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Номер записи: 35
19-01-2017 дата публикации

ANTIOXIDANT ENRICHED DISTILLED ALCOHOL PRODUCT AND PROCESS THEREFOR

Номер: US20170014466A1
Автор: Gillis Alan B., Gillis Judith M., Gillis Rodney J., LEE Hyun Suk
Принадлежит:

A process for producing a distilled ethanol product comprising an antioxidant component and an ethanol component is described. In the process, plant matter containing antioxidants is washed, frozen and exposed to an input volume of ethanol. Antioxidants are ethanolically extracted from the frozen plant matter. The plant matter and the liquid ethanol fractions are then separated and the plant matter having antioxidants extracted therefrom is used to produce ethanol which is subsequently used to extract antioxidants from a second batch of plant matter. The ethanol fraction having antioxidants therein is stored or diluted for later use. 1. A process for producing an antioxidant containing distilled ethanol product comprising:freezing antioxidant containing plant matter, suitable for use in the production of ethanol, to render a frozen plant material;subjecting the frozen plant material to a volume of a distilled input ethanol product so as to ethanolically extract antioxidants from the frozen plant material and render an antioxidant-rich ethanol fluid mixture having therein remnant solid plant matter;separating the remnant solid plant matter from the antioxidant-rich ethanol fluid mixture so as to obtain said antioxidant containing distilled ethanol product; andproducing a subsequent distilled ethanol product from said remnant solid plant matter; the subsequent distilled ethanol product being used as the distilled input ethanol product in a subsequent cycles for producing at least a further volume of said antioxidant containing distilled ethanol product.2. The process as defined in claim 1 , wherein the frozen plant material is subjected to the volume of distilled input ethanol product until the remnant solid plant matter is substantially devoid of antioxidants.3. The process as defined in claim 1 , wherein the distilled input ethanol product has an ethanol concentration of from about 70% to about 99%.4. The process as defined in claim 1 , wherein the frozen plant ...

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Номер записи: 36
17-01-2019 дата публикации

A NANOBIOCOMPOSITE FORMULATION FOR WOUND HEALING AND A PROCESS FOR THE PREPARATION THEREOF

Номер: US20190015468A1
Автор: Kumari Avnesh, Singla Rubbel, Yadav Sudesh Kumar
Принадлежит:

The present invention involves the isolation of plant based CNCs from the leaves of . For the formation of NCs, a novel greener approach using LE as reducing agent for in situ impregnation of AgNPs as fillers into CNCs as matrix is reported. The silver nitrate solution in three different concentrations of 1 mM, 5 mM and 10 mM was used to form NCs where AgNPs have been incorporated into CNCs matrix. The CNCs and NCs were characterized using SEM, TEM, XRD, Zeta potential, FT-IR, and UV-Vis spectroscopy. NCs developed in the form of film and ointment showed strong antimicrobial activity against both gram negative and gram positive bacteria. NCs wound dressing is capable of regulating wound exudates and providing moisture to wound responsible for faster healing of acute wounds. The observations from histopathological and biochemical assays confirmed that NCs enhance healing because of lesser inflammation, rapid angiogenesis, early collagen formation and enhanced rate of reepithelization. 1Syzygium cumini. A nanobiocomposite formulation (NCs) in ointment form comprising silver nanoparticles (AgNPs) and cellulose nanocrystals (CNCs) wherein the ratio of AgNPs and CNCs is in the range of 0.067%-0.4% w/w AgNPs: 7-8% w/w CNCs , and wherein the cellulose is derived from leaves.2. A process for the preparation of the nanobiocomposite formulation in ointment form as claimed in claim 1 , the method comprising:{'i': 'Syzygium cumini', 'a) treating washed and dried leaves with bleaching agent at pH in the range of 3.0-4.0 for a time period ranging between 2-3 h at a temperature ranging between 70-100° C. to obtain a bleached fibrous material;'}b) filtering and washing the bleached fibrous material as obtained from (a) followed by treating with acidified bleaching agent solution at a temperature ranging between 22-30° C. for a time period ranging 16-18 h to obtain acidified fibrous material;c) washing the acidified fibrous material as obtained from (b) followed by keeping it into 2 ...

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Номер записи: 37
26-01-2017 дата публикации

SINGLE SERVE BEVERAGE POD CONTAINING CANNABIS

Номер: US20170020814A1
Автор: BENSON Ronald Stuart, GEMMITI Claudio, HOBBES Peter, PLATT IIana Deborah
Принадлежит:

Single-serve containers for use in brewing a cannabis-based beverage are described, as are methods for preparing a single-serve container configured for receipt in a single-serve brewing machine. The method includes: adding a processed cannabis product to the single-serve container; adding, to the single-serve container, at least one of an extraction or flavoring agent; and sealing the single-serve container. 1. A method of preparing a packaged beverage product , the method comprising:processing cannabis by heating the cannabis to decarboxylate the cannabis;adding the processed cannabis to the packaged beverage product;adding, to the packaged beverage product, an effective amount of a lipid-rich food-based extraction agent, wherein the extraction agent is a powder and is solid at room temperature; andsealing the packaged beverage product.2. The method of claim 1 , wherein the extraction agent is selected from the group consisting of milk powder claim 1 , powdered dairy creamer claim 1 , powdered non-dairy creamer claim 1 , cocoa powder claim 1 , chocolate powder claim 1 , powdered coconut flakes claim 1 , coconut flour claim 1 , flax meal powder claim 1 , quinoa flour claim 1 , and almond flour.3. The method of claim 1 , further comprising claim 1 , prior to sealing:adding, to the packaged beverage product, a flavoring agent.4. The method of claim 3 , wherein the flavoring agent is selected from the group consisting of:tea, coffee or chocolate, latte or cappuccino.5. The method of claim 1 , further comprising:pulverizing the cannabis.6. The method of claim 5 , wherein pulverizing comprises pulverizing the cannabis to a particle size of 2 millimeters or less.7. The method of claim 5 , wherein pulverizing comprises pulverizing the cannabis to a particle size of 1 millimeter or less.8. The method of claim 5 , further comprising claim 5 , after pulverizing claim 5 , filtering the pulverized cannabis to separate cannabis having a desired particle size.9. The method of ...

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Номер записи: 38
25-01-2018 дата публикации

WEIGHT LOSS/REDUCTION OF VISCERAL FAT COMPOUND AND METHOD OF EXTRACTION AND PREPARATION

Номер: US20180021268A1
Автор: Hackel Vincent
Принадлежит: JBSL-USA, INCORPORATED

A composition for weight loss comprising at least 8% total chalcones comprising 4-hydroxyderricin and xanthoangelol and coumarins. A composition for reduction of visceral fat comprising at least 8% total chalcones comprising 4-hydroxyderricin and xanthoangelol and coumarins. A method to isolate and purify chalcones. 1. A composition for weight loss comprising:a) at least 8% total chalcones comprising 4-hydroxyderricin and xanthoangelol; andb) coumarins.2. The composition of claim 1 , wherein the coumarins are selected from a group comprising furanocoumarin type coumarins and dihydropyrano-coumarins.3. The composition of claim 2 , wherein the furanocoumarins are selected from a group comprising xanthotoxin (psoralen) claim 2 , isopimpinellin claim 2 , bergapten claim 2 , and imperatorin.4. The composition of claim 2 , wherein the dihydropyrano-coumarins are selected from a group comprising laserpitin claim 2 , isolaserpitin claim 2 , and selinidin.5. The composition of claim 1 , wherein the amounts of coumarins comprises approximately 35 mg/g to 45 mg/g.6. A composition for reduction of visceral fat comprising:a) at least 8% total chalcones comprising 4-hydroxyderricin and xanthoangelol; andb) coumarins.7. The composition of claim 6 , wherein the coumarins are selected from a group comprising furanocoumarin type coumarins and dihydropyrano-coumarins.8. The composition of claim 7 , wherein the furanocoumarins are selected from a group comprising xanthotoxin (psoralen) claim 7 , isopimpinellin claim 7 , bergapten claim 7 , and imperatorin.9. The composition of claim 7 , wherein the dihydropyrano-coumarins are selected from a group comprising laserpitin claim 7 , isolaserpitin claim 7 , and selinidin.10. The composition of claim 6 , wherein the amounts of coumarins comprises approximately 35 mg/g to 45 mg/g.11. A method to isolate and purify chalcones.12. A method for inducing weight loss comprising administration of an effective amount of chalcone powder obtained by ...

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Номер записи: 39
25-01-2018 дата публикации

FERMENTED PENNISETUM EXTRACT

Номер: US20180021398A1
Автор: Shih Ming-Chi
Принадлежит:

The invention provides a fermented extract, which has an advantageous effect in treating and preventing a cancer without toxicity to normal cells. The invention also provides a process of preparing the fermented extract and the application of the fermented extract in the treatment or prevention of a cancer. 1Pennisetum. A fermented extract , comprising a compound ZG5236 having a chromatograph having at least a peak at retention times of 17.18 to 17.98 minutes assayed by HPLC.2. The extract of claim 1 , wherein the peak is at retention time of about 17.53 minutes.3. The extract of claim 1 , which further comprises a compound ZG5235 having a chromatograph having the peak at retention times of: 16.20 to 17.10 minutes claim 1 , and/or a compound ZG5237 having a chromatograph having the peak at retention times of: 19.00 to 19.36 minutes.4. The extract of claim 3 , wherein the peak of ZG5235 is at a retention time of about 16.63 minutes and the peak of ZG5237 is at a retention time of about 19.18 minutes.5. The extract of claim 3 , wherein ZG5236 accounts for 5.88% of the extract. In another embodiment claim 3 , the amounts of ZG5235 and ZG5237 account for 1.47% and 0.13% claim 3 , respectively6PennisetumAspergillus niger. The extract of claim 1 , which is prepared by the process comprising the following steps: (a) culturing solution with for a biotransformation; (b) collecting the solution and then extracting an extract with an organic solvent; and (c) analyzing the extract by High Performance Liquid Chromatography (HPLC) at 330 nm.7. The extract of claim 6 , wherein the amount of ZG5236 after biotransformation increases about 20.99% in comparison with that before biotransformation claim 6 , or the amounts of ZG5235 and ZG5237 after biotransformation reduce about 8.8% and about 1.39% claim 6 , respectively.8PennisetumPennisetum alopecuroidesPennisetum clandestinum, Pennisetum polystachionPennisetum purpureumPennisetum setosum.. The extract of claim 1 , wherein the is ...

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Номер записи: 40
10-02-2022 дата публикации

COMPOSITIONS COMPRISING CBD FOR TREATING MENTAL DISORDERS

Номер: US20220040124A1
Автор: LAVON Ilana, LAYANI Omer, MUKHTAR Shaul
Принадлежит:

The present invention discloses compositions comprising CBD and several herbal extract and use thereof in treatment of mental disorders such as Attention Deficit Hyperactivity disorder (ADHD) and Post Traumatic Stress Disorder (PTSD). 116-. (canceled)17Bacopa monnieriCentella AsiaticaWithania Somnifera. A composition comprising from about 5 to about 22% by weight of CBD oil , from about 15 to about 40% by weight of extract , from about 15 to about 40% by weight of extract , and from about 15 to about 40% by weight of extract.18. The composition according to claim 17 , comprising from about 8 to about 20% by weight of CBD oil.19. The composition according to claim 17 , wherein said CBD oil comprises from about 55 to about 75% by weight of CBD.20. The composition according to claim 17 , wherein the CBD oil is obtained from plant extract claim 17 , or is synthetically prepared.21Bacopa monnieri. The composition according to claim 17 , comprising from about 25 to about 35% by weight of extract.22Centella Asiatica. The composition according to claim 17 , comprising from about 25 to about 35% weight of extract.23Withania Somnifera. The composition according to claim 17 , comprising from about 25 to about 35% by weight of extract.24Bacopa monnieriCentella AsiaticaWithania Somnifera. The composition according to claim 17 , comprising from about 8 to about 22% by weight of CBD oil claim 17 , from about 25 to about 35% by weight of extract claim 17 , from about 25 to about 35% by weight of extract claim 17 , and about from about 25 to about 35% by weight of extract.25. The composition according to claim 17 , wherein the composition further comprises an orally acceptable carrier.26. The composition according to claim 17 , wherein the composition is a pharmaceutical composition comprising one or more pharmaceutically acceptable excipients.27. The composition according to claim 17 , formulated for a systemic administration.28. The composition of claim 27 , wherein the systemic ...

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Номер записи: 41
10-02-2022 дата публикации

Methods of treating tuberous sclerosis complex with cannabidiol and everolimus

Номер: US20220040155A1
Автор: David Critchley, Eduardo Dunayevich, Geoffrey Guy, Volker KNAPPERTZ
Принадлежит: GW Research Ltd

The present disclosure provides methods of treating tuberous sclerosis complex comprising administering cannabidiol and everolimus.

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Номер записи: 42
24-01-2019 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF LIVER DISEASE

Номер: US20190022161A1
Автор: Kang Han Eun
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating liver disease, and more particularly, to a pharmaceutical composition capable of preventing or treating liver disease by using a fermented product of , and a method of producing the same. 1Orostachys japonicus. A pharmaceutical composition comprising a fermented product of as an effective component for prevention or treatment of a liver disease.2Orostachys japonicusOrostachys japonicus. The pharmaceutical composition of the claim 1 , wherein the fermented product of may be produced by fermenting by more than one of an enzyme and a culture solution of a fermentation strain.3Orostachys japonicusOrostachys japonicus. The pharmaceutical composition of the claim 2 , wherein the fermented product of is obtained by firstly fermenting with an enzyme and then fermented secondarily with a culture solution of fermentation strain.4. The pharmaceutical composition of the claim 2 , wherein the enzyme is more than one selected from a group consisting of cellulase claim 2 , hemicellulase claim 2 , and amyloglucosidase.5. The pharmaceutical composition of the claim 4 , wherein the enzyme is a mixture in which cellulase claim 4 , hemicellulase and amyloglucosidase are mixed according to a weight ratio of 0.5 to 1.5:0.5 to 1.5:0.5 to 1.5.6Lactobacillus hilgardii, Leuconostoc mesenteroides, Pediococcus acidilacticiSaccharomyces cerevisiae.. The pharmaceutical composition of the claim 2 , wherein the fermentation strain includes more than one strains selected from a group consisting of and7Pediococcus acidilactici.. The pharmaceutical composition of the claim 6 , wherein the fermentation strain includes8. The pharmaceutical composition of the claim 2 , wherein a culture solution of the fermentation strain includes the fermentation strain in an amount of 10to 10cells/ml.9. The pharmaceutical composition of the claim 1 , wherein the fermented product is a lyophilizate.10. The pharmaceutical ...

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Номер записи: 43
10-02-2022 дата публикации

Method for Separating Phenolic Acid Glucoside Compounds from Diaphragma juglandis Fructu

Номер: US20220041639A1
Автор: SUN Xiulan, XU DEPING, Xu Yida, ZHANG Yinzhi
Принадлежит:

The disclosure discloses a method for separating phenolic acid glucoside compounds from , belonging to the technical field of food. The method includes the following steps: (1) extraction: crushing , and then extracting by using ethanol to obtain walnut ethanol extract; and (2) separation: performing column chromatography on the walnut ethanol extract obtained in step (1), sequentially eluting by using ethanol of different concentrations, purifying and eluting repeatedly, and performing separation to obtain phenolic acid glucoside compounds. The phenolic acid glucoside compounds are 2-hydroxyl-5-methoxylphenyl-O-β-D-glucopyranoside, 6-hydroxylnaphthyl-1,2-di-O-β-D-glucopyranoside and 2,6-dihydroxynaphthyl-O-β-D-glucopyranoside. Pharmacological experiments confirm that the three compounds have good antioxidant activity. 1Diaphragma juglandis Fructus. A method for separating phenolic acid glucoside compounds from , comprising the following steps:{'i': 'Diaphragma juglandis Fructus', '(1) extraction: crushing , and then extracting by using ethanol to obtain walnut ethanol extract; and'}(2) separation: putting the walnut ethanol extract obtained in step (1) into an MCI column, sequentially eluting by using deionized water, 30% ethanol, 50% ethanol and 70% ethanol, collecting and then combining a water elution fraction and a 30% ethanol elution fraction, performing reduced-pressure concentration on the combined eluent, putting a sample into an MCI column, sequentially performing gradient elution by using deionized water, 10% ethanol, 20% ethanol, 30% ethanol and 50% ethanol, collecting a 10% ethanol elution fraction, performing reduced-pressure concentration on the 10% ethanol elution fraction, then loading a sample into an ODS column, sequentially eluting by using deionized water, 5% ethanol solution, 10% ethanol solution and 20% ethanol solution, collecting the eluent, then purifying and eluting repeatedly, and performing separation to obtain phenolic acid glucoside ...

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Номер записи: 44
28-01-2021 дата публикации

Production of Ethanol-free Vanilla Extracts

Номер: US20210022381A1
Автор: Brennecke Stefan, Heinemeyer Martin, Kiefl Johannes, Winkler Dominik
Принадлежит:

The present invention relates to a process for producing an ethanol-free vanilla extract, and an ethanol-free vanilla extract obtainable by the process according to the invention. In particular, the present invention relates to an ethanol-free vanilla extract comprising at most 100 mg/kg ethanol, the use of this ethanol-free vanilla extract and products comprising the ethanol-free vanilla extract. The focus of the present invention is in particular to provide an ethanol-free vanilla extract which contains only traces of ethanol naturally contained in fermented vanilla beans and is produced without the use of ethanol. 1. A process for preparing an ethanol-free vanilla extract comprising:(a) preparing fermented vanilla beans;(b) crushing the fermented vanilla beans;(c) extracting the crushed vanilla beans with an organic extraction solvent or an extraction solvent mixture comprising at least one organic extraction solvent having a log P value of from −0.8 to 0.4 to obtain a raw extract;(d) adding a protective solvent to the raw extract;(e) filtering the raw extract;(f) distilling off the extraction solvent or the extraction solvent mixture from the raw extract to obtain a vanilla extract; and(g) optionally, phase separating and separating the liquid vanilla extract freed from the extraction solvent or extraction solvent mixture.2. The process of claim 1 , wherein the organic extraction solvent having a log P value of −0.8 to 0.4 is selected from the group consisting of methanol claim 1 , acetone claim 1 , propan-2-ol claim 1 , propan-1-ol claim 1 , methyl acetate claim 1 , ethyl methyl ketone claim 1 , and a combination of any of the foregoing.3. The process according to claim 1 , wherein extracting the crushed vanilla beans is carried out with acetone.4. The process according to claim 1 , wherein the extraction solvent or the extraction solvent mixture is added to crushed vanilla beans in a ratio in a range of 1:1 (w/w) to 40:1 (w/w).5. The process according to claim ...

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Номер записи: 45
23-01-2020 дата публикации

GANODERMA LUCIDUM POLYSACCHARIDES COMPOSITE COMPOSITION

Номер: US20200023024A1
Автор: JIN JINN-DER
Принадлежит: GeneFerm Biotechnology Co., Ltd.

A polysaccharides composite composition comprising, based on a total composition: 1 to 5 wt. % β-glucan extract, 1 to 5 wt. % mycelium extract, 1 to 5 wt. % mycelium extract, 1 to 5 wt. % Berk extract, 1 to 5 wt. % -extract, 1 to 5 wt. % extract, 1 to 3 wt. % fruiting body extract, and water. 1Ganoderma lucidumGanoderma lucidumTrametes versicolorTremella fuciformisAuricularia auriculajudaeHericium erinaceusGanoderma lucidum. A polysaccharides composite composition comprising , based on a total composition: 1 to 5 wt. % β-glucan extract , 1 to 5 wt. % mycelium extract , 1 to 5 wt. % mycelium extract , 1 to 5 wt. % Berk extract , 1 to 5 wt. % -extract , 1 to 5 wt. % extract , 1 to 3 wt. % fruiting body extract , and water.2Ganoderma lucidumAureobasidium pullulans.. The polysaccharides composite composition of claim 1 , wherein the β-glucan extract further comprises a β-glucan extract of3Ganoderma lucidum. The polysaccharides composite composition of claim 1 , further comprising a flavor modulator claim 1 , wherein the flavor modulator comprises citric acid.4Ganoderma lucidum. The polysaccharides composite composition of claim 1 , further comprising a sweetener claim 1 , wherein the sweetener comprises acesulfame potassium.5Ganoderma lucidum. The polysaccharides composite composition of claim 1 , further comprising a juice concentrate claim 1 , wherein the juice concentrate comprises orange juice concentrate.6Ganoderma lucidum. The polysaccharides composite composition of claim 1 , wherein the composition is provided in a powder form claim 1 , a beverage form claim 1 , or an encapsulated form.7Ganoderma lucidumAureobasidium pullulansGanoderma lucidumTrametes versicolorTremella fuciformisAuricularia auriculajudaeHericium erinaceusGanoderma lucidumGanoderma lucidumTrametes versicolorTremella fuciformisAuricularia auriculajudaeHericium erinaceusGanoderma lucidumGanoderma lucidum. A method for producing a polysaccharides composite composition claim 1 , comprising steps of: ...

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Номер записи: 46
28-01-2021 дата публикации

CANNABIS SCREW CONVEYOR PROCESSOR AND MEMBRANE SYSTEM AND METHODS

Номер: US20210023155A1
Автор: Opperman Robert
Принадлежит: Marquette Analytica

The disclosure relates to a continuous plant material processing system comprising ultrasonic treatment of plant material coupled to a membrane system for the efficient recovery of cannabinoids. 1195-. (canceled)196Cannabis. A method for processing plant material comprising{'i': 'Cannabis', 'claim-text': [{'i': 'Cannabis', 'wherein the extraction tank comprises a screw conveyor located inside the extraction tank, the screw conveyor capable of moving the plant material from the first end to the second end,'}, {'i': 'Cannabis', 'applying ultrasonic cavitation with an ultrasonic cavitation device to the mixture of the plant material and at least one solvent in the extraction tank to produce a miscella stream;'}, 'filtering the miscella stream through at least one filter;', 'filtering the filtered miscella stream through at least one membrane to produce a cannabinoid extract., 'combining plant material and at least one solvent in an extraction tank to produce a miscella stream,'}197. The method of claim 196 , wherein the sonication device is horn claim 196 , probe claim 196 , cup claim 196 , or rod shaped.198. The method of claim 196 , wherein the sonication device produces an ultrasound frequency between 1 kHz to 100 kHz.199. The method of claim 196 , wherein the ultrasonic cavitation is applied for 1-180 seconds.200Cannabis. The method of claim 196 , wherein the method further comprising moving the plant material to an output port located at the second end.2011. The method of claim claim 196 , wherein the screw conveyor is a varied geometry screw conveyor.2021. The method of claim claim 196 , wherein the screw conveyor has a central axis claim 196 , the central axis making an incline angle θ of about 1° to about 90° C. relative to a horizontal plane intersecting the central axis.2031. The method of claim claim 196 , wherein the solvent is an alcohol.204. The method of claim 203 , wherein the alcohol is methanol claim 203 , ethanol claim 203 , n-propanol claim 203 , 1- ...

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Номер записи: 47
02-02-2017 дата публикации

Purified Extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient, the preparation thereof, and the composition comprising the same as an active ingredient for preventing or treating inflammation, allergy and asthma

Номер: US20170028010A1
Автор: AHN Kyung-seop, Kim Doo-Young, KIM Jung-Hee, Kwon Ok-Kyoung, LEE Hyeongkyu, LEE Yongnam, Oh Sei-Ryang, RYOO Byung-hwan, SHIN Dae-hee, SONG Hyuk-hwan, YOO Ji-seok
Принадлежит:

The present invention relates to inventive novel industrialized method for preparing purified extract containing more abundant active ingredients such as catalpol derivatives from the extract of var than that prepared by the conventional preparation method disclosed in the prior art and the therapeutics or functional health food comprising the purified extract for treating and preventing inflammatory, allergic or asthmatic disease. The purified extract showed more potent anti-inflammatory, anti-allergy and anti-asthma activity than that prepared by the conventional preparation method disclosed in the prior art through various in vivo tests such as inhibition test on the reproduction of eosinophil, the release of immunoglobulin and inflammatory chemokines in plasma and bronchoalveolar fluid as well as the suppression of airway hyperresponsiveness and goblet cell hyperplasia in a OVA-sensitized/challenged mouse model. 122.-. (canceled)23Pseudolysimachion rotundumsubintegrumPseudolysimachion rotundumsubintegrum.. A purified extract fractionated with butanol (ATC1) from the extract of var , comprising 15%-50% (w/w) verproside , 0.3%-10% (w/w) veratric acid , 0.5%-10% (w/w) catalposide , 0.3%-10% (w/w) picroside II , 0.3%-10% (w/w) isovanilloyl catalpol and 0.5%-10% (w/w) 6-O-veratroyl catalpol based on the weight of total extract (100%) of var24Pseudolysimachion rotundumsubintegrumPseudolysimachion rotundumsubintegrum. A purified extract fractionated with butanol (ATC1) from the extract of var , comprising 12.3%-47% (w/w) catalpol derivatives in total extract (100%) of var and which has a relative mixed ratio (w/w) between the weight of each catalpol derivative of 15.0-18.0 (w/w) verproside , 2.10-2.60 (w/w) catalposide , 1 (w/w) picroside II , 1.00-1.30 (w/w) isovanilloyl catalpol and 2.00-2.30 (w/w) 6-O-veratroyl catalpol.25Pseudolysimachion rotundumsubintegrum. A pharmaceutical composition comprising the purified extract fractionated with butanol (ATC1) as set forth ...

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Номер записи: 48
01-02-2018 дата публикации

PROCEDURE FOR PREPARATION OF A PRODUCT BASED OF THE LEAVES OF THE PLANT SEDUM TELEPHIUM FOR THE TREATMENT OF NAILS INFECTED WITH ONYCHOMYCOSIS.

Номер: US20180028586A1
Автор: González Hernandez Angel
Принадлежит:

Procedure for preparation of a product based on the leaves of the plant Sedum telephium for the treatment of nails infected with onychomycosis. The procedure consists in strip away the skin of the leaf of the Sedum telephium plant of one of its faces, after which the stripped face is impregnated with sulfanilamide powder and then applied as a dressing on nails infected with onychomycosis. It is also used for topical application in the form of cream or ointment on nails infected with onychomycosis. 1. A method of preparing a product based on the leaves of the Sedum telephium plant comprising the following steps:a) Strip the skin that protects the leaf of the Sedum telephium plant from one side.b) Once stripped the sheet impregnated superficially with sulfanilamide powder.2. A product based on the leaves of the Sedum telephium plant obtained according to the process steps of .3. Use of the product according to for manufacturing a topical medicament for the treatment of nails infected with onychomycosis. The present invention relates to the preparation of a product by which infection of the human nail known as onychomycosis is cured.The main object of this invention is the use of the plant leaf Sedum telephium which together with sulfanilamide powder impregnated in adequate proportion achieves the cure of onychomycosis.Plaster for the treatment of onychomycosis is already known. For example, WO99/40955 A discloses a pressure sensitive steel matrix patch for the treatment of onychomycosis. This device for treating fungal infections of the nails is comprised of an occlusive backing layer and a pressure sensitive adhesive matrix layer, wherein an effective amount of an antifungal agent is evenly dispersed, optionally with a chemical improver.Another treatment for treating onychomycosis is described in U.S. Pat. No. 5,464,610 A. Such a treatment uses a plaster preparation comprising salicylic acid or a salt, ester or mixture thereof. The plaster preparation is connected to ...

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Номер записи: 49
17-02-2022 дата публикации

COMPOSITION COMPRISING OIL PALM PHENOLICS FOR USE IN THE TREATMENT AND PREVENTION OF COLON DISEASES AND FOR PROMOTING AND MAINTAINING GUT AND GENERAL HEALTH

Номер: US20220047666A1
Автор: ABEYWARDENA Mahinda, Sambanthamurthi Ravigadevi, SYED ABU BAKAR Syed Fairus, Tan Yew Ai
Принадлежит: Malaysian Palm Oil Board (MPOB)

The present invention relates to a composition for the treatment of colon disorder comprising oil palm polyphenolics (OPP) and fibres extracted from the vegetation liquor generated during the milling and extraction of oil from the oil palm fruit administered to a patient in an effective concentration of 50 mg gallic acid equivalents (GAE). The present invention further relates to a method of treatment and prevention of colon disorders and maintenance of gut health. 1. A composition for the treatment or prevention of colon disorders comprises:oil palm polyphenolics (OPP) and fibres extracted from the vegetation liquor generated during the milling and extraction of oil from the oil palm fruit administered to a patient in an effective concentration of 50 mg gallic acid equivalents (GAE).2. The composition according to claim 1 , wherein the composition is administered to the patient along with food or with drinking water.3. The composition according to claim 1 , wherein the composition inhibits the colorectal cancer (CRC) by causing lesser colon DNA damage and increasing mucus barrier protection in large intestine of the patient.4. The composition according to claim 1 , wherein the composition is administered for treatment and prevention of colon disorders by increasing cecal digesta.5. The composition according to claim 1 , wherein the composition increases acetate claim 1 , propionate and cecal butyrate concentration in large intestine.6. The composition according to claim 1 , wherein the composition is administered as a pharmaceutical claim 1 , nutraceutical claim 1 , supplement or beverage composition.7. The composition according to claim 1 , wherein the composition is in solid or liquid dosage form.8Faecalibacterium prausnitzii, Akkermansia muciniphilaRuminococcus gnavus.. The composition according to claim 1 , wherein the composition increases a number of cecal digesta bacteria in large intestine of the patient claim 1 , wherein the bacteria are and9. A method for ...

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Номер записи: 50
31-01-2019 дата публикации

DETOXIFYING COMPOSITION FOR ORAL ADMINISTRATION AND METHOD FOR PREPARING SAME

Номер: US20190030111A1
Автор: HAY Ly Eang
Принадлежит:

A detoxifying composition for oral administration includes dried inflorescence stems from the pepper plant, that are optionally ground and optionally sieved, and/or a liquid or dry extract of pepper plant inflorescence stems. The pepper plant inflorescence stems are advantageously chosen from inflorescence stems from the , or pepper plants. The food composition or supplement or fortified foodstuff or dietary product containing same is used in order to promote the elimination of waste from the organism, in particular by the liver. 1. A detoxifying composition for oral administration , wherein said detoxifying composition comprises dried , optionally ground and optionally screened pepper plant inflorescence stems and/or a liquid or dry extract of pepper plant inflorescence stems.2Piper nigrumPiper longum.. The composition as claimed in claim 1 , wherein the pepper plant inflorescence stems are chosen from the inflorescence stems of the pepper plant or3. The composition as claimed in either of claim 1 , wherein the extract is an extract of said inflorescence stems with a polar solvent.4. The composition as claimed in claim 1 , wherein said composition contains at least 1% by weight.5. The composition as claimed in claim 1 , wherein said composition is in a drinkable form claim 1 , such as in the form of an infusion claim 1 , a decoction claim 1 , a maceration claim 1 , a flavored drink or any other drinkable form.6. A food supplement or a fortified food or a dietetic product comprising the composition as claimed in claim 1 , in weight proportions of between 0.1% and 85%.7. The food supplement or fortified food or dietetic product as claimed in claim 6 , wherein said food supplement also comprises at least one active agent chosen from: vitamins claim 6 , such as vitamin B6 or C; carotenoids claim 6 , such as beta-carotene or lutein; mineral trace elements claim 6 , such as magnesium claim 6 , calcium or iron; or extracts of rosemary claim 6 , blessed milkthistle claim 6 ...

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Номер записи: 51
30-01-2020 дата публикации

Method for producing fermented bamboo extract and immunostimulating agent

Номер: US20200029610A1
Автор: Osamu TAMAI
Принадлежит: Individual

An object of the present invention is to provide a new application of bamboo based on new functions. A method for producing a fermented bamboo extract comprises a pulverization step of pulverizing bamboo to obtain bamboo powder, a fermentation step of fermenting the bamboo powder with lactic acid bacteria to obtain a fermented bamboo product, and an extraction step of subjecting the fermented bamboo product to hot water extraction to obtain an extract.

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Номер записи: 52
30-01-2020 дата публикации

Method and apparatus for harvesting trichomes from cannabis plants

Номер: US20200030397A1
Автор: Andrew Vincent SHLANTA, Eric Charles BENDER, Mark Wayne LANHAM, Michael Robert Himes
Принадлежит: Air Products and Chemicals Inc

A method of harvesting trichomes from a cannabis plant piece containing one or more trichomes attached to biomass material, the biomass material including one or more of stalk material, flower material, and leaf material, including freezing a cannabis plant piece by exposing the plant piece to a cryogenic fluid to create a frozen plant piece; processing the frozen plant piece to separate the trichomes from the biomass material using one or more screens; removing the biomass that has been prevented from passing through the one or more screens; and collecting the trichomes that have passed through the one or more screens.

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Номер записи: 53
04-02-2021 дата публикации

METHOD FOR PREPARING ADDITIVE-FREE CELL-WALL-BROKEN GRANULE OF CHINESE MEDICINAL MATERIAL

Номер: US20210030684A1
Автор: CAO Xiaojun, CHEN Jinmei, Chen Weixuan, Chen Yongjun, CHENG Jinle, DENG Wen, LAI Zhitian, LIANG Yanling, PENG Lihua, QIAO Weilin, WANG Yina, XU Jiyin
Принадлежит: ZHONGSHAN ZHONGZHI PHARMACEUTICAL GROUP CO., LTD.

The present invention provides a method for preparing an additive-free cell-wall-broken granule of a Chinese medicinal material. The cell-wall-broken granule is obtained by medicinal material concocting and grinding, first cell-wall-breaking and grinding, screening, second wall-breaking and grinding, mixing, pelleting, and granulating and sieving. The obtained granule has a moderate tightness, a relatively rapid dissolution and diffusion and a good uniformity, overcoming problems of a difficulty of dissolution and diffusion and a poor uniformity of the existing cell-wall-broken granules. 1. A method for preparing an additive-free cell-wall-broken granule of a Chinese medicinal material comprising the following steps:(1) medicinal material concocting: picking, washing, slicing and drying a medicinal material to obtain a clean medicinal material;(2) medicinal material grinding: taking and grinding the clean medicinal material with a mill to obtain an 80-120 mesh medicinal coarse powder;(3) first cell-wall-breaking and grinding: performing cell-wall-breaking and grinding on the obtained medicinal coarse powder to obtain a 200-1000 mesh cell-wall-broken powder;(4) particle size screening: screening the cell-wall-broken powder to separate a 300-1000 mesh cell-wall-broken powder;(5) second cell-wall-breaking and grinding: returning the screened powder with a mesh below 300 to a cell-wall-breaking and grinding cavity for re-grinding so that it is cell-wall-broken and ground into a 300-500 mesh cell-wall-broken powder;(6) mixing: mixing different materials obtained from two times of the cell-wall-breaking and grinding to obtain a uniform cell-wall-broken powder with different particle sizes and different cell ingredients which are evenly distributed;(7) pelleting: placing the cell-wall-broken powder recovered in the step (6) into a mixing agitator, adding a high-concentration ethanol-water solution and a low-concentration ethanol-water solution alternately to make a soft ...

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Номер записи: 54
08-02-2018 дата публикации

PROCESS TO OBTAIN A NUTRACEUTICAL FORMULATION OF AMARANTH AND ITS USE IN TREATING HUMAN BEHAVIOR DISORDERS

Номер: US20180036359A1
Автор: Garcia Manuel Soriano
Принадлежит:

The present invention relates to a novel process to manufacture a nutraceutical formulation of amaranth, made from amaranth whole seeds. The nutraceutical formulation of amaranth obtained by the present invention has unique characteristics for addressing problems of great relevance in the priority field of public health, which significantly affects people in general, that is to say, the use in treating human behavioral disorders such as depression, stress, anxiety, and extreme cases like schizophrenia and bipolar disorder 130-. (canceled)31Amaranthus hypochondriacus. A nutraceutical formulation of amaranth wherein contains proteins with a high content of essential amino acids , unsaturated fatty acids , squalene , antioxidants , minerals and carbohydrates.32. A nutraceutical formulation of amaranth in accordance with in the form a soluble powder and/or capsules.33. A nutraceutical formulation of amaranth in accordance with claim 31 , wherein the formulation is a liquid.34. A nutraceutical formulation of amaranth in accordance with claim 31 , wherein the formulation is characterized by a solid presentation content of 43 to 47% of protein by weight of the total composition claim 31 , 1-3% of lipids by weight of the total composition claim 31 , 1-2% of salts by weight of the total composition claim 31 , from 39 to 43% of carbohydrates by weight of the total composition claim 31 , 3.0 to 3.50% of soluble fiber by weight of the total composition and from 3.5 to 4.0% moisture by weight of the total composition35. A nutraceutical formulation of amaranth in accordance with claim 31 , further characterized as having a good solubility in water at different temperatures from 4 to 60° C.36. A process of preparing a nutraceutical product of Amaranth which includes selecting claim 31 , clean seeds by sieves claim 31 , washing the seeds with water claim 31 , soaking the seeds with water free of microorganisms claim 31 , washing the seeds soaked with water free of microorganisms ...

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Номер записи: 55
09-02-2017 дата публикации

Hop extract oxidation-reaction product, preparing method thereof and use thereof

Номер: US20170037345A1
Автор: Fumitoshi Manabe, Mikio Katayama, Yoshimasa Taniguchi, Yumie Kobayashi
Принадлежит: Kirin Holdings Co Ltd

The present invention relates to a hop extract having a reduced bitter taste which shows a fat absorption suppressing effect. More specifically the present invention relates to a hop extract oxidation-reaction product obtained by an oxidation-reaction of a hop extract.

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Номер записи: 56
24-02-2022 дата публикации

SYSTEMS, METHODS, AND EQUIPMENT FOR CHEMICAL EXTRACTION

Номер: US20220054568A1
Автор: Cullimore Reese, Mehos Greg, Sherwood Raechel, Sherwood Steven
Принадлежит:

Novel thermal evaporative processes for the recovery of heat-sensitive constituents, raw essential oil concentrates, and other compounds from plant biomass material are disclosed, as are systems for implementing such processes. Particularly, the processes include a solvent-less process for either batch-wise or continuous removal and recover), of refined oils, such as volatile aroma components and heavier oils, from plant material. 1. A method for extracting at least one chemical compound from plant material , comprising:a) preparing a feedstock by at least one of chopping, cutting, treating, pelletizing, and grinding the plant material;b) preheating the feedstock to a first temperature at atmospheric or sub-atmospheric pressure for a preselected time to form a preheated feedstock;c) heating the preheated feedstock to a second temperature at sub-atmospheric pressure in an evaporation chamber to form a heated feedstock;d) flowing a heated motive gas through the evaporation chamber to drive the at least one chemical compound from the heated feedstock, thereby forming a pregnant motive gas; ande) condensing a portion of the pregnant motive gas to recover the at least one chemical compound.2Cannabis.. The method of claim 1 , wherein the plant material comprises a plant of the genus3. The method of claim 1 , wherein the motive gas comprises a non-oxidizing gas.4. The method of claim 1 , wherein the at least one chemical compound comprises at least one cannabinoid.5. The method of claim 1 , wherein the at least one chemical compound comprises at least one terpene or terpenoid.6. A method for extracting at least one chemical compound from plant material claim 1 , comprising:{'claim-text': ['a1) at least one of chopping, cutting, treating, pelletizing, and grinding the plant material to form a size-reduced plant material, and', 'a2) contacting the size-reduced plant material with a solution of at least one carboxylic ester hydrolase enzyme in water to form the feedstock;'], ...

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Номер записи: 57
24-02-2022 дата публикации

PHARMACEUTICAL COMPOSITIONS AND USE THEREOF

Номер: US20220054572A1
Автор: REN Xuefeng, XIE Be
Принадлежит:

The present application relates to methods of preventing, treating or managing a respiratory disease and/or a viral infection (e.g., an influenza virus infection and COVID-19) using a pharmaceutical composition produced from one or more preparations of plant parts. Provided herein are the pharmaceutical compositions produced from the one or more preparations. Also provided herein are methods of producing the pharmaceutical composition from the one or more preparations. 1. A method of preventing , treating or managing a respiratory disease and/or a viral infection , comprising administering to a subject in need of such prevention , treatment , or management a pharmaceutical composition produced from one or more preparations comprising(i) a preparation of the grassy stem of Ephedra sinica Stapf;{'sub': ['4', '2'], '#text': '(ii) Gypsum ore (CaSO.2HO);'}(iii) a preparation of the seed (nut) of Semen Armeniacae Amarum; and/or(iv) a preparation of the dried root and rhizome of Glycyrrhiza uralensis Fisch., andwherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier.2. The method according to claim 1 , wherein the respiratory disease and/or the viral infection is pneumonia claim 1 , an influenza virus infection claim 1 , or a coronavirus infection.36.-. (canceled)7. The method according to claim 2 , wherein the coronavirus infection is coronavirus disease 2019 (COVID-19).812.-. (canceled)13. The method according to claim 1 , wherein the method further comprises administering to the subject a second agent.14. The method according to claim 13 , wherein the second agent is an antiviral agent claim 13 , an anti-inflammatory agent claim 13 , a Janus kinase inhibitor claim 13 , a steroid hormone claim 13 , an immunosuppressive agent claim 13 , an agent targeting interleukin-6 receptor claim 13 , an antibacterial agent claim 13 , an anti-parasitic agent claim 13 , Traditional Chinese medicine claim 13 , stem cells claim 13 , convalescent plasma ...

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Номер записи: 58
24-02-2022 дата публикации

PHARMACEUTICAL COMPOSITIONS AND USE THEREOF

Номер: US20220054573A1
Автор: REN Xuefeng, XIE Be
Принадлежит:

The present application relates to methods of preventing, treating or managing chronic obstructive pulmonary disease (COPD) and/or other obstructive lung diseases using a pharmaceutical composition produced from one or more preparations of plant parts. Provided herein are the pharmaceutical compositions produced from the preparations. Also provided herein are methods of producing the pharmaceutical compositions. 1. A method of preventing , treating or managing chronic obstructive pulmonary disease (COPD) , comprising administering to a subject in need of such prevention , treatment , or management a pharmaceutical composition produced from preparations comprising:{'i': 'Poria cocos', '(i) a preparation of the dried sclerotia of (Schw.) Wolf;'}and one or more of{'i': 'Semen armeniacae amarum', '(ii) a preparation of the seed (nut) of ; and'}{'i': 'Glycyrrhiza uralensis', '(iii) a preparation of the dried root and rhizome of Fisch.,'}wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier.2. The method according to claim 1 , wherein the COPD is caused by the condition of emphysema and/or chronic bronchitis.3. (canceled)4. The method according to claim 1 , wherein the pharmaceutical composition is administered via oral route.5. The method according to claim 1 , wherein the method further comprises administering to the patient a second agent.6. The method according to claim 5 , wherein the second agent is a bronchodilator claim 5 , a steroid claim 5 , a phosphodiesterase-4 inhibitor claim 5 , an antibiotic claim 5 , a mucoactive agent claim 5 , an anti-cancer agent claim 5 , an agent blocking interleukin (IL)-5 or its receptor claim 5 , or a combination thereof.7. (canceled)8. The method according to claim 1 , wherein the preparations comprise:{'i': 'Poria cocos', '(i) the preparation of the dried sclerotia of (Schw.) Wolf in an amount of 2 wt. % to 60 wt. % or 5 g to 35 g;'}and one or more of{'i': 'Semen armeniacae amarum', '(ii) the ...

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Номер записи: 59
24-02-2022 дата публикации

PHARMACEUTICAL COMPOSITIONS AND USE THEREOF

Номер: US20220054574A1
Автор: REN Xuefeng, XIE Be
Принадлежит:

The present application relates to methods of preventing, treating or managing a respiratory disease and/or a viral infection (e.g., an influenza virus infection and COVID-19) using a pharmaceutical composition produced from one or more preparations of plant parts. Provided herein are the pharmaceutical compositions produced from the one or more preparations. Also provided herein are methods of producing the pharmaceutical composition from the one or more preparations. 1. A method of preventing , treating or managing a respiratory disease and/or a viral infection , comprising administering to a subject in need of such prevention , treatment , or management a pharmaceutical composition produced from preparations comprising:{'i': 'Illicium verum', '(i) a preparation of the fruit of ; and'}{'i': Sclerotium', 'Poria cocos, '(ii) a preparation of the dried of (Schw.) Wolf, in the weight ratio from 1:1 to 1:10, and'}wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier.2. The method according to claim 1 , wherein the respiratory disease is pneumonia.3. The method according to claim 1 , wherein the respiratory disease and/or the viral infection is an influenza virus infection.4. The method according to claim 3 , wherein the influenza virus is influenza virus A.5. The method according to claim 1 , wherein the respiratory disease and/or the viral infection is a coronavirus infection.6. The method according to claim 5 , wherein the coronavirus is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).7. The method according to claim 5 , wherein the coronavirus infection is coronavirus disease 2019 (COVID-19).8. The method according to any one of to claim 5 , wherein the method prevents the respiratory disease and/or the viral infection.9. A method of preventing claim 5 , treating or managing COVID-19 claim 5 , comprising administering to a subject in need of such prevention claim 5 , treatment claim 5 , or management a pharmaceutical ...

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Номер записи: 60
24-02-2022 дата публикации

Methods and compositions for treating coronavirus infections

Номер: US20220054601A1
Автор: Erick Vidjin' Agnih Gbodossou, Michael Powell
Принадлежит: Morehouse School of Medicine Inc

The present application relates to a compositions and methods comprising or expressing a HEVAR or MOMO30 protein derived from Momordica balsamina. The HEVAR or MOMO30 protein and/or a nucleic acid encoding the same may be used in methods for treating or preventing viral infections, particularly those caused by coronaviruses, such as SARS-CoV-2.

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Номер записи: 61
07-02-2019 дата публикации

Method for conversion and extraction of beneficial components in ginseng

Номер: US20190038691A1
Автор: Ken Lee
Принадлежит: Egeonhoco ltd, EgeonjoCo ltd

Provided is a method for conversion and extraction of beneficial components, the method including: a vacuum step for feeding ginseng into a vacuum chamber and applying a vacuum pressure thereinto; and a treatment step for heating and drying the ginseng under the vacuum pressure, so that the loss of beneficial components can be minimized and the treatment cost can be lowered by simplifying the treatment procedure and shortening the treatment time, and the saponin conversion and extraction efficiencies can be effectively increased through a simple treatment procedure.

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Номер записи: 62
15-02-2018 дата публикации

NON-BLEEDING BIOACTIVE NATURAL PIGMENTS WHICH PREVENT COLOR AND DUST EXPLOSIONS, METHOD OF PREPARATION THEREOF

Номер: US20180042858A1
Автор: Madhavamenon Krishnakumar Illathu, MALIAKEL Balu Paulose
Принадлежит:

A non-bleeding curcumin (NBC) which eliminate the problems of color bleeding, color leaching, color staining and dusting during the industrial processing of curcumin and its methods of preparation is disclosed in the invention. The invention also provides a water based process of preparation of food grade non-bleeding curcumin which is free of synthetic excipients. 1. A Non-bleeding curcumin (NBC) comprising curcumin and a coating of polymer , wherein the polymer is selected from the group consisting of a biopolymer , synthetic polymer or a mixture thereof.2. The non-bleeding curcumin of claim 1 , wherein the biopolymer is selected from the group consisting of cellulose claim 1 , shellac claim 1 , galactomannans claim 1 , glucomannans claim 1 , arabinoxylans claim 1 , natural gums claim 1 , proteins or a mixture thereof and the synthetic polymers is selected from the group consisting of polyvinyl alcohol claim 1 , polylactic acids or a mixture thereof.3. The non-bleeding curcumin of claim 1 , wherein the curcumin comprises curcumin claim 1 , demethoxycurcumin and bisdemethoxycurcumin in substantially the similar ratio as of standard curcumin.4. The non-bleeding curcumin of claim 1 , wherein the NBC is in the form of powder claim 1 , granules claim 1 , pellets claim 1 , micropellets claim 1 , beads claim 1 , beadlets.5. The non-bleeding curcumin of claim 1 , wherein the NBC having the particle size distribution in the range of 120 to 2000 microns.6. The non-bleeding curcumin of claim 1 , wherein the curcumin is used in bioavailable formulation such as tablets claim 1 , capsules along with other excipients.7. The non-bleeding curcumin of claim 1 , wherein the NBC contains enhanced concentration of curcuminoids not less than 90% (w/w) and up to 95% (w/w) suitable for various formulations.8. The non-bleeding curcumin of claim 1 , wherein the curcumin prevents color leakage claim 1 , bleeding claim 1 , staining or dusting during industrial processing of curcumin ...

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Номер записи: 63
15-02-2018 дата публикации

PHARMACEUTICAL COMPOSITION CONTAINING SILIBININ

Номер: US20180042892A1
Автор: BAI Xiaolin, He Yi, Li Lei, LI Ting, Ma Xiaohui, SUN He, Wu Naifeng, Yan Kaijing, Yan Xijun, Zhang Shunnan, Zhu Yonghong
Принадлежит:

Disclosed is a pharmaceutical composition containing silibinin, which is prepared from the following bulk drugs by weight ratio: 8.75-60 parts of silibinin, 15-65 parts of phospholipid, and 25-200 parts of Pu'er tea extract. The drug has the function of treating non-alcoholic fatty liver. 1. A pharmaceutical composition comprising:8.75-60 by weight parts of silibinin;15-65 parts by weight of phospholipid; and25-200 parts by weight of Pu'er tea extract.2. A pharmaceutical composition according to comprising:25-40 parts by weight of silibinin;30-50 parts by weight of phospholipid; and80-120 parts by weight of Pu'er tea extract.3. A pharmaceutical composition according to comprising:35 parts of silibinin;42 parts of phospholipid; and100 parts of Pu'er tea extract.4. A pharmaceutical preparation comprising the pharmaceutical composition according to claim 1 , and pharmaceutically acceptable carriers;wherein the pharmaceutically acceptable carriers are 0.1-99.9% of the total preparation by weight; orwherein the pharmaceutically acceptable carriers are 40-70% of the total preparation by weight.5. The pharmaceutical preparation according to claim 4 , wherein the pharmaceutically acceptable carriers comprise one or more of mannitol claim 4 , sorbitol claim 4 , sorbic acid or sylvite claim 4 , sodium metabisulfite claim 4 , sodium bisulfite claim 4 , sodium thiosulfate claim 4 , cysteine hydrochloride claim 4 , mercaptoacetic acid claim 4 , methionine claim 4 , vitamin A claim 4 , vitamin C claim 4 , vitamin E claim 4 , vitamin D claim 4 , azone claim 4 , disodium EDTA claim 4 , calcium disodium EDTA claim 4 , the carbonate claim 4 , acetate claim 4 , phosphate of monovalence alkali metal or aqueous solution thereof claim 4 , hydrochloric acid claim 4 , acetic acid claim 4 , sulfuric acid claim 4 , phosphoric acid claim 4 , amino acid claim 4 , sodium chloride claim 4 , potassium chloride claim 4 , sodium lactate claim 4 , xylitol claim 4 , maltose claim 4 , glucose claim 4 ...

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Номер записи: 64
15-02-2018 дата публикации

PHARMACEUTICAL COMPOSITION CONTAINING SILYBIN

Номер: US20180042893A1
Автор: BAI Xiaolin, He Yi, LI Ting, MA Xiaohni, SUN He, Wu Naifeng, YAN Kaijirig, Yan Xijun, Zhang Shunnan, Zhu Yonghong
Принадлежит:

A pharmaceutical composition for treating non-alcoholic fatty liver diseases consists of a silybin-phospholipid complex preparation and Pu'er tea/tea product according to a weight ratio of 0.5-2.5:0.3-10, wherein the silybin-phospholipid complex capsule preparation and the Pu'er teat/tea product are separately packaged. 1. A pharmaceutical composition , comprisinga silybin-phospholipid complex pharmaceutical preparation and a Pu'er tea/Pu'er tea product, wherein the silybin-phospholipid complex pharmaceutical preparation and the Pu'er tea/Pu'er tea product are contained in separate packages according to unit dose andthe separate packages are further contained in one large package, andwherein the silybin-phospholipid complex pharmaceutical preparation and the Pu'er tea/Pu'er tea product are administrated in combination according to respective doses to a subject in need thereof.2. The pharmaceutical composition according to claim 1 , wherein the weight ratio of the silybin-phospholipid complex to the Pu'er tea/Pu'er tea product is 0.5-2.5:0.3-10.3. The pharmaceutical composition according to claim 2 , wherein the weight ratio of the silybin-phospholipid complex to the Pu'er tea/Pu'er tea product is 1-2:0.6-5.4. The pharmaceutical composition according to claim 1 , wherein the weight ratio of the silybin-phospholipid complex to the Pu'er tea/Pu'er tea product is (1-1.3):1.5. The pharmaceutical composition according to claim 1 , wherein the silybin-phospholipid complex comprises 10-60% of the total weight of the silybin-phospholipid complex pharmaceutical preparation claim 1 , preferably wherein the silybin-phospholipid complex comprises 30-50% of the total weight of the silybin-phospholipid complex pharmaceutical preparation claim 1 , and even more preferably wherein the silybin-phospholipid complex comprises 40% of the total weight of the silybin-phospholipid complex pharmaceutical preparation.6. The pharmaceutical composition according to claim 1 , wherein the weight ...

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Номер записи: 65
15-02-2018 дата публикации

USE OF A WITHANIA EXTRACT FOR THE TREATMENT OF AMYLOID-RELATED DISEASES

Номер: US20180042979A1
Автор: Arcile Guillaume, Cariel Léon, Ouanzzani Jamal, Rabhi Chérif
Принадлежит:

The invention relates to the use of a composition from a plant extract of , to treat or prevent amyloid-related diseases, including Alzheimer disease. 1Withania somnifera. Composition containing a extract for its use to treat or prevent amyloid-related diseases in a mammal , preferably a human.2Withania somnifera. Composition according to claim 1 , in which the extract has been fermented by its incubation with a filamentous fungus in a suitable environment.3CordycipitaceaeBeauveriaBeauveria bassiana.. Composition according to or claim 1 , in which the fermentation is carried out with a filamentous fungus of the family claim 1 , preferably from the genus and claim 1 , more particularly claim 1 ,4Emblica officinalis, Bacopa monnieri, Punica granatum, Curcuma longa, Piper longumCalendula officinalis.. Composition according to any of to claim 1 , further containing at least one extract from the following plants: claim 1 , or5Emblica officinalisBacopa monnieri.. Composition according to any of to claim 1 , further containing an extract of and an extract of6Withania somniferaWithania somnifera. Composition according to any of to claim 1 , comprising a quantity by weight of of between 5 and 100 g/L of claim 1 , and preferably 20 g/L.7Withania somniferaEmblica officinalis. Composition according to any of to claim 1 , comprising a quantity by weight of at a concentration of 20 g/L claim 1 , of at a concentration of 15 g/L and of Bacopa monnieri at a concentration of 15 g/L.8. Composition according to any of to claim 1 , for its use to treat or prevent Alzheimer's disease claim 1 , cerebral amyloid angiopathy claim 1 , inclusion body myositis or Down's syndrome.9. A method of treating or preventing an amyloid-related disease in a subject claim 1 , comprising administering to a subject a therapeutic amount of a plant extract composition claim 1 , such that said amyloid-related disease in a subject is treated or prevented claim 1 , wherein said composition contains a plant ...

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Номер записи: 66
03-03-2022 дата публикации

EXTRACT, CONSUMABLE PRODUCT AND METHOD FOR ENRICHING BIOACTIVE METABOLITE IN AN EXTRACT

Номер: US20220061370A1
Автор: CHAE Lee Heil, Flatt James, Herrmann Alexandra Marcela, Navarro Gabriel, Ochoa Jessica Leigh
Принадлежит:

This disclosure relates to methods and compositions with enhanced levels of one or more tyramine containing hydroxycinnamic acid amides. Also disclosed herein are methods for producing a consumable product with enhanced levels of a tyramine containing hydroxycinnamic acid amide. Some embodiments relate to a composition enriched with a tyramine containing hydroxycinnamic acid.

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Номер записи: 67
03-03-2022 дата публикации

METHOD AND COMPOSITIONS FOR THE USE OF BOTANICAL EXTRACTS IN THE TREATMENT OF VIRAL INFECTIONS

Номер: US20220062365A1
Автор: Denzler Karen, Jacobs Bertram, LANGLAND Jeffrey, Waters Robert
Принадлежит:

The present disclosure relates generally to the preparation and use of certain botanical extracts and therapeutic compositions for the treatment of viral infections, cancer, pain, itch, and inflammation. The present disclosure generally relates to antiviral compositions, and more specifically to the preparation of botanical extracts and their use in the treatment of viral infections, cancer, pain associated conditions. 1Sarracenia, Nepenthes, Melissa, Lavandula, Glycyrrhiza, Eleutherococcus, Hypericum, Darlingtonia, Heliamphora, Roridula, Drosera, Dionaea, Aldrovanda, Drosophyllum, Triphyophyllum, Catopsis, Brocchinia, Paepalanthus, Utricularia, Genlisea, Pinguicula, Ibicella, Byblis, Philcoxia, StylidiumCephalotus. A method for inhibiting the replication of a poxvirus by exposing the poxvirus to an extract from a plant material chosen from and , wherein the plant material is prepared by steps comprising:obtaining fresh plant material less than about ten (10) days following harvest of the plant material;washing and air drying the plant material;combining the plant material with a liquid comprising at least one of water, ethanol, and glycerol;allowing the liquid to extract the plant material at a temperature between about room temperature and simmering for about one (1) to about sixty (60) days, or by boiling for less than about one day to form the liquid extract; andseparating the liquid extract from the plant material.2. The method of claim 1 , wherein the plant material consists of leaves.3. The method of claim 1 , wherein the plant material consists of roots.4. The method of claim 1 , wherein the plant material comprises leaves and roots.5. The method of claim 1 , wherein the poxvirus is selected from the group consisting of orthopoxvirus claim 1 , parpoxvirus claim 1 , avipoxvirus claim 1 , capripoxvirus claim 1 , leporipoxvirus claim 1 , suipoxvirus claim 1 , molluscipox virus claim 1 , and yatapox virus.6. The method of claim 1 , wherein the poxvirus is a ...

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Номер записи: 68
13-02-2020 дата публикации

Method of microalgal biomass processing for high-value chemicals production, the resulting composition of butyrogenic algal slowly fermenting dietary fiber, and a way to improve colon health using a slowly fermenting butyrogenic algal dietary fiber

Номер: US20200046003A1
Автор: Benmoussa Mustapha
Принадлежит:

A method to process microalgae biomass and produce high-value chemicals from microalgae biomass is disclosed. The method uses the same biomass cells to extract more than one component such as are lipids, water-soluble chemicals, carotenoids, polysaccharides and algae meal. The method is a sequence of physical and chemical treatments. Water soluble polysaccharides produced by the method exhibit properties of low viscosity at low shear thinning. A method for extracting dietary fiber from microalgal biomass is disclosed. Compositions of water-soluble polysaccharides that are fermented slowly by colon microbiota with less gas production than commercial dietary fiber FOS are disclosed. The present inventions described herein provide a method of improving colon health by increasing butyrate during a microalgal dietary fiber fermenting process by colonic microbiota. 1. A method to extract and isolate compounds from an algal biomass comprising:physically treating the algal biomass by micro fluidization or ultra-sonication with a frequency greater than 20 KHz using a probe-type sonication or bath sonication, optionally in combination with extrusion using an extruder or with addition of a solvent, wherein the solvent is hexane, followed by centrifugation, wherein centrifugation was performed at a speed of about 500 rpm to about 15000 rpm, wherein centrifugation was performed at a speed of about 1000 rpm to about 10000 rpm, wherein centrifugation was performed at a speed of about 2000 rpm to about 5000 rpm, followed byextracting lipids and other oils from the top, the water soluble chemicals from the middle and the pellet from the bottom,hydrothermally treating the pellet by heating at high pH, optionally in combination with high pressure, while stirring, followed bycentrifugation of the hydrothermally treated pellet at 2500 rpm for 10 minutes or 4000 rpm for 15 min,separating the supernatant from the resulting residue,precipitating water-soluble polysaccharides from the ...

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Номер записи: 69
13-02-2020 дата публикации

METHOD FOR OBTAINING OLIVE OIL AND AT LEAST ONE EXTRACT CONCENTRATED IN POLYPHENOLS AND A FUNCTIONAL INGREDIENT

Номер: US20200046791A1
Автор: MATEO ANSÓN Nuria
Принадлежит: ISANATUR SPAIN S.L.

A method comprising the stages of: olive input, separation of the stone from the olive skin and pulp, with the removal of the whole stone; electric pulsing of the olive paste generated in the previous stage, process of dehydration of the pulsed olive paste up to a humidity of less than 30% in a continuous vacuum drying machine and subsequent separation of the oil by centrifugation of the olive oil, followed by dehydration of the degreased pulp up to a humidity of less than 10%; and lastly, application of supercritical fluids (CO2 with or without modifier) to the degreased and dehydrated pulp, under agitation, pressure, temperature and time conditions, obtaining olive extracts and olive flour. The generation of waste, consumption of water, use of highly toxic solvents and loss of the sensory quality of the oil is avoided, the yields improved and the necessary times reduced. 1. A method for obtaining olive oil and at least one polyphenol concentrated extract and a functional ingredient characterised in that it comprises the stages of:{'b': 2', '3, 'Separating () the stone and skin from the olive pulp, obtaining the whole stone () on the one hand and, on the other, an olive paste;'}{'b': '4', 'Electric pulsing () of the olive paste with an electric field voltage of 1-3 kV/cm, frequency of 114-255 Hz and 2-10 pulses of 50-90 microseconds;'}{'b': '5', 'Dehydrating () the pulsed olive paste up to a humidity of <30% in a continuous vacuum drying machine under the following conditions: vacuum (<80 mbar of absolute pressure), temperature (<41° C.) and time (20-100 kg of evaporated water/h) or other conditions that preserve the thermolabile compounds of interest;'}{'b': 6', '7, 'Separating () the oil from the olive paste by centrifugation in a decanter with the necessary adjustments to treat de-stoned dehydrated pulp and obtainment of virgin olive oil ();'}{'b': '8', 'Dehydrating () the degreased pulp, after separating the oil, up to a humidity of less than 10% applying ...

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Номер записи: 70
10-03-2022 дата публикации

Aloe extract and methods for producing the same

Номер: US20220072080A1
Автор: Chih-Sheng Hung, Lung-Yao WANG, Thomas Chen, Yi-Ru Chen
Принадлежит: Dazzeon Biotechnology Co Ltd

Disclosed herein is a method for preparing an aloe extract. The method comprises steps of, mincing a mesophyll of an Aloe in water; heating the minced mixture to 60-80° C.; filtering the mixture to produce a first filtrate; drying the first filtrate; reconstituting the dried first filtrate in water; subjecting the first filtrate or the reconstituent to column chromatography and eluting the column with a first polar solvent; concentrating the eluent; purifying the concentrate with active carbons; filtering the purified concentrate to produce a second filtrate; concentrating the second filtrate; and adding a second polar solvent to the concentrated second filtrate thereby producing the aloe extract. The present disclosure also encompasses the aloe extract prepared by the present method. Said aloe extract has desired contents of O-acetyl groups or polysaccharides, and is useful for manufacturing food, pharmaceutical, or cosmetic products.

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Номер записи: 71
21-02-2019 дата публикации

Method of microalgal biomass processing for high-value chemicals production, the resulting composition of butyrogenic algal slowly fermenting dietary fiber, and a way to improve colon health using a slowly fermenting butyrogenic algal dietary fiber

Номер: US20190053523A1
Автор: Mustapha Benmoussa
Принадлежит: Individual

A method to process microalgae biomass and produce high-value chemicals from microalgae biomass is disclosed. The method uses the same biomass cells to extract more than one component such as are lipids, water-soluble chemicals, carotenoids, polysaccharides and algae meal. The method is a sequence of physical and chemical treatments. Water soluble polysaccharides produced by the method exhibit properties of low viscosity at low shear thinning. A method for extracting dietary fiber from microalgal biomass is disclosed. Compositions of water-soluble polysaccharides that are fermented slowly by colon microbiota with less gas production than commercial dietary fiber FOS are disclosed. The present inventions described herein provide a method of improving colon health by increasing butyrate during a microalgal dietary fiber fermenting process by colonic microbiota.

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Номер записи: 72
01-03-2018 дата публикации

PHARMAECUTICAL COMPOSITION CONTAINING SILYBIN, VE AND L-CARNITINE

Номер: US20180055817A1
Автор: BAI Xiaolin, He Yi, Li Lei, LI Ting, Ma Xiaohui, SUN He, Wu Naifeng, Yan Kaijing, Yan Xijun, Zhang Shunnan, Zhu Yonghong
Принадлежит:

A pharmaceutical composition. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 8.75-60 parts of silybin, 15-65 parts of phospholipid, 25-200 parts of a Pu'er tea extract, 6.25-40 parts of vitamin E, and 8.3-60 parts of L-carnitine. The composition can be used for treating non-alcoholic fatty liver diseases. 1. A pharmaceutical composition comprising:8.75-60 parts by weight of silybin;15-65 parts by weight of phospholipid;25-200 parts by weight of Pu'er tea extract;6.25-40 parts by weight of vitamin E; and8.3-60 parts by weight of L-carnitine.2. The pharmaceutical composition according to comprising:25-40 parts by weight of silybin;30-50 parts by weight of phospholipid;80-120 parts by weight of Pu'er tea extract;10-30 parts by weight of vitamin E; and25-40 parts by weight of L-carnitine.3. The pharmaceutical composition according to comprising:35 parts by weight of silybin;42 parts by weight of phospholipid;100 parts by weight of Pu'er tea extracts;16.7 parts by weight of vitamin E; and33.3 parts by weight of L-carnitine.4. The pharmaceutical composition according to claim 1 , wherein the vitamin E is vitamin E acetate or vitamin E succinate.5. The pharmaceutical composition according to claim 1 , wherein the L-carnitine is L-carnitine tartrate.6. A pharmaceutical preparation comprising the pharmaceutical composition according to claim 1 , and pharmaceutically acceptable carriers;wherein the pharmaceutically acceptable carriers are 0.1-99.9% of the total preparation by weight;the pharmaceutically acceptable carriers are 40-70% of the total preparation by weight.7. The pharmaceutical preparation according to claim 6 , wherein the pharmaceutically acceptable carriers comprise one or more of mannitol claim 6 , sorbitol claim 6 , sorbic acid or sylvite claim 6 , sodium metabisulfite claim 6 , sodium bisulfite claim 6 , sodium thiosulfate claim 6 , cysteine hydrochloride claim 6 , mercaptoacetic acid claim 6 , methionine ...

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Номер записи: 73
21-02-2019 дата публикации

COMPOSITIONS AND METHODS FOR EXTRACTION OF BOTANICAL COMPOUNDS FROM PLANTS

Номер: US20190054008A1
Автор: CHAN Diva
Принадлежит: AMYRIS, INC.

The present invention provides methods, compositions and kits for extracting botanical compounds from plant parts using a carrier medium comprising a bio-based farnesene, a hydrocarbon composition derived from the bio-based farnesene or a combination thereof. In certain embodiments, rose petals are used as a plant material, and a squalane composition derived from bio-based farnesene is used as a carrier medium. 1. A method of extracting botanical compounds from a plant or plant material comprising:(a) contacting a plant material comprising one or more botanical compounds with a carrier medium to produce a mixture, wherein the carrier medium comprises a bio-based farnesene, a hydrocarbon composition derived from the bio-based farnesene, or a combination thereof; and(b) incubating the mixture to extract the botanical compounds from the plant material into the carrier medium to produce a botanical infused product comprising the botanical compounds.2. The method of claim 1 , wherein the carrier medium comprises a C15 hydrocarbon claim 1 , C30 hydrocarbon claim 1 , or a combination thereof.3. The method of claim 2 , wherein the carrier medium comprises farnesene claim 2 , partially hydrogenated farnesene claim 2 , squalane claim 2 , farnesene dimer claim 2 , farnesene dimer claim 2 , or any combination thereof.4. The method of claim 3 , wherein the carrier medium comprises squalane.5. The method of claim 4 , wherein the carrier medium further comprises isosqualane.6. The method of claim 5 , wherein the proportion of squalane to isosqualane in the carrier medium is between about 2:1 to about 25:1.7. The method of claim 1 , wherein the carrier medium comprises a partially hydrogenated farnesene.89.-. (canceled)10gardeniaverbenaginseng. The method of claim 1 , wherein the plant material is selected from a whole plant claim 1 , stem claim 1 , flower claim 1 , root claim 1 , seeds claim 1 , fruit claim 1 , leaf claim 1 , bark claim 1 , carpels claim 1 , stamen claim 1 , ...

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Номер записи: 74
01-03-2018 дата публикации

METHOD FOR PRODUCING AN EXTRACT OF A MATRIX OF VEGETABLE ORIGIN BY EXTRUSION WITH A HYDROTROPE SOLUTION

Номер: US20180055900A1
Автор: LETI Mathieu, Mandeau Anne
Принадлежит: PIERRE FABRE DERMO-COSMETIQUE

The invention relates to a method for producing an extract of a matrix of vegetable origin, particularly a plant, characterised in that the matrix of vegetable origin undergoes a mechanical treatment consisting in extruding the matrix of vegetable origin in an extruder, in association or not with a heat treatment, in the presence of an aqueous solution containing at least one hydrotrope agent, particularly at a concentration at least equal to the minimum hydrotrope concentration thereof, followed by an operation of recovering the extract. 1. Method for obtaining an extract of a vegetable matrix , particularly plant matrix , characterized in that the vegetable matrix is subjected to mechanical treatment consisting of extruding the vegetable matrix in an extruder , associated or not with heat treatment , in the presence of an aqueous solution containing at least one hydrotropic agent , in particular at a concentration at least equal to the minimum hydrotropic concentration , followed by an operation to recover the extract.2. The method according to claim 1 , characterized in that the hydrotropic agent is of ionic type claim 1 , selected in particular from among sodium n-butyl benzene sulfonate claim 1 , sodium cumene sulfonate claim 1 , sodium paratoluene sulfonate or sodium xylene sulfonate.3. The method according to claim 1 , characterized in that the hydrotropic agent is of non-ionic type claim 1 , preferably agri-sourced claim 1 , in particular an alkyl-(poly)glycoside of general formula Alk-O-Zp claim 1 , where:Alk designates a hydrophobic, aliphatic hydrocarbon fragment, saturated or unsaturated, straight-chain or branched, having 3 to 7 carbon atoms, andZ is a hydrophilic glycoside group such as glucose, xylose and arabinose, and1 Подробнее

Номер записи: 75
01-03-2018 дата публикации

Composition for preventing, treating and improving of voiding dysfunction comprising extract from Piper longum L.

Номер: US20180055902A1
Автор: Chan-Seok JEON, Da-Ae PARK, Hyun-Yong Lee, Kwang-Hyun Kim, Sang-Ho Lee, Yoon-Young Chang
Принадлежит: Dong Wha Pharm Co Ltd

The present invention relates to a pharmaceutical composition for preventing or treating voiding dysfunction and a health functional food for preventing or improving of voiding dysfunction, comprising extract of Piper Longum L. as an active ingredient. The extract of Piper Longum L. according to the present invention is not only harmless, but also has outstanding effects of preventing, treating and improving voiding dysfunction by being involved in various mechanisms related to voiding dysfunction simultaneously so that it may increase a micturition interval, decrease a micturition pressure, increase a bladder capacity, inhibit detrusor contraction and induce relaxation of detrusor.

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Номер записи: 76
01-03-2018 дата публикации

Banana fermentation product and manufacturing method and use of the same

Номер: US20180055905A1
Автор: Cheng-Yu Ho, Po-Chun Hsu, Yung-Hsiang Lin
Принадлежит: TCI Co Ltd

The present invention provides a banana fermentation product, which is obtained by subjecting a banana pulp juice to a pre-fermentation and then a post-fermentation, wherein the pre-fermentation is conducted in the presence of Streptococcus thermophiles and yeast and the post-fermentation is conducted in the presence of Acetobacter . The banana fermentation product of the present invention is effective in anti-oxidation, increasing the amount of probiotics in the intestinal tract, reducing the amount of bad bacteria in the intestinal tract, and relieving constipation symptoms. The banana fermentation product of the present invention can further be used for providing an edible composition or a pharmaceutical composition.

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Номер записи: 77
04-03-2021 дата публикации

COSMETIC ACTIVE SUBSTANCE OBTAINED THROUGH BIOCONVERSION BY LACTOBACILLUS ARIZONENSIS OF ITS ORIGINAL SUBSTRATE, METHOD FOR OBTAINING SAME COMPOSITION COMPRISING SAME, AND USES

Номер: US20210059929A1
Автор: PAUFIQUE Jean
Принадлежит:

The invention relates to a particular cosmetic active substance that is constituted through bioconversion by of its original substrate, . The invention also relates to a preparation method, to compositions comprising same, and to uses thereof for cosmetic applications. 1Lactobacillus arizonensisSimmondsia chinensis.. A cosmetic active substance , characterized in that it is the product obtained through bioconversion by of2Lactobacillus arizonensisSimmondsia chinensis.. The cosmetic active substance according to claim 1 , characterized in that it is obtained from the supernatant obtained through bioconversion by of3Lactobacillus arizonensisSimmondsia chinensis.. The cosmetic active substance according to claim 1 , characterized in that it is the supernatant obtained through bioconversion by of4. The cosmetic active substance according to claim 1 , characterized in that it comprises sugars.5. The cosmetic active substance according to claim 1 , characterized in that the carbohydrate fraction of the active substance comprises polysaccharides and oligosaccharides of glucose claim 1 , galactose claim 1 , and fructose.6. The active substance according to claim 1 , characterized in that it comprises at least one cyclic polyol.7. The cosmetic active substance according to claim 1 , characterized in that it comprises at least Pinnitol.8. The cosmetic active substance according to claim 1 , characterized in that it comprises proteins and/or minerals and/or lactic acid.9. The active substance according to claim 1 , characterized in that it is in liquid form.10. A cosmetic composition claim 1 , comprising at least 0.1 wt. % of an active substance according to .11. The cosmetic composition according to claim 1 , characterized in that it is in the form of a cream or gel.12. A method for obtaining an active substance according to claim 1 , characterized in that it comprises the following steps:{'i': Lactobacillus arizonensis', 'Simmondsia chinensis, 'Culturing of in a culture ...

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Номер записи: 78
02-03-2017 дата публикации

APPLICATION OF FRUCTUS SCHISANDRAE TOTAL POLYSACCHARIDES IN PREPARATOIN OF MEDICINE OR NUTRACEUTICALS USED FOR TREATING COUGHING

Номер: US20170056431A1
Автор: Gan Zhenyong, LAI Kefang, Liu Xiaodong, NIE Yichu, ZHONG Nanshan, Zhong Shan
Принадлежит:

The present invention relates to a new application of Fructus schisandrae total polysaccharides in preparation of medicine or nutraceuticals for treating coughing, and more specifically to a new application of Fructus schisandrae total polysaccharides in preparation of medicine or nutraceuticals for preventing and relieving coughing and eliminating airway inflammation. Experiments demonstrate that the Fructus schisandrae total polysaccharides can remarkably reduce the coughing times of a guinea pig with increased cough sensitivity induced by cigarette smoke and an acute cough guinea pig induced by citric acid smoke, prolong the latent period of cough, and significantly reduce the airway inflammation of the guinea pig with increased cough susceptibility induced by cigarette smoke, so that the Fructus schisandrae total polysaccharides can be used for preparing drugs for preventing cough, relieving cough and eliminating airway inflammation. 1. An application of Fructus schisandrae total polysaccharides in preparation of medicine or nutraceuticals used for treating coughing , characterized in that the medicine or nutraceuticals are used for treating acute cough , sub-acute cough or chronic cough; and the Fructus schisandrae total polysaccharides are prepared through the following steps: pulverizing Fructus schisandrae , degreasing the pulverized Fructus schisandrae with petroleum ether , decocting the degreased Fructus schisandrae for three times by using 8 times water , concentrating obtained decocted liquid , precipitating the concentrated solution by using 80% ethanol , filtering , performing deproteinization through a precipitation enzymatic method , decoloring by using active carbon , repeatedly washing by using 80% ethanol , and then drying to obtain the Fructus schisandrae total polysaccharides , and the content of polysaccharides in the Fructus schisandrae total polysaccharides is 89% through test on the basis of D-glucose.2. The application according to claim 1 ...

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Номер записи: 79
04-03-2021 дата публикации

Method for obtaining saponins from plants

Номер: US20210060106A1
Автор: Andres VALENCIA MICHAUD, Leandro PADILLA IGLESIAS
Принадлежит: Desert King Chile SA

The present application relates to a method for obtaining and purifying saponins from plant extracts, through a series of salting and filtrations steps, to provide high purity saponin extracts on large scale.

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Номер записи: 80
20-02-2020 дата публикации

ENZYME-ASSISTED SUPERCRITICAL EXTRACTION OF NIGELLA SATIVA SEEDS

Номер: US20200054704A1
Автор: ITTIYAVIRAH Sibi Perumbamkudiyil, Madhavamenon Krishnakumar Illathu, MALIAKEL Balu Paulose, RAMALINGAM Kannan
Принадлежит:

The present invention relates to novel black cumin extract compositions and a green process for making the composition. The black cumin extract composition of the invention can be used to treat anxiety, sleep and stress disorders along with significant effect on memory enhancement. The composition is available in oil and powder forms. 1. A process for preparing a biologically active black cumin seed extract in free flowing powder form using black cumin seeds , comprising:(a) pre-treating powdered or flaked black cumin seeds with enzymes, followed by supercritical carbon dioxide extraction of the oil from the seeds to obtain a super critical extracted oil fraction which comprises non-volatile fixed oils rich in α-linoleic acid and volatile oils rich in thymoquinone;(b) extracting the residual black cumin seed material left after step (a) with a hydrophilic solvent to obtain residual black cumin seed extract;(c) spray-drying the residual black cumin seed extract from step (b) to obtain a residual black cumin seed free flowing powder;(d) dissolving the residual black cumin seed extract free flowing powder from step (c) in water to obtain a residual black cumin seed extract solution at 10 to 25% total dissolved solids level;(e) mixing the supercritical extracted oil fraction from step (a) with the residual black cumin seed solution obtained step (d), followed by homogenization or ultrasonication of the mixture thus obtained to produce an emulsion; and(f) spray-drying or freeze drying the emulsion from step (e) to obtain black cumin seed extracted oil composition in free flowing powder form;wherein the black cumin seed extracted oil composition in free flowing powder form comprises thymoquinone in the range of 0.1 to 8%.2. A process for preparing biologically active black cumin seed extract in liquid oil form using black cumin seeds , comprising:(a) pre-treating the powdered or flaked black cumin seeds with water to form a slurry and further treating the slurry with at ...

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Номер записи: 81
20-02-2020 дата публикации

SYSTEMS AND METHODS OF CANNABIS OIL EXTRACTION

Номер: US20200054962A1
Автор: Dimitrelos Geronimos, Vanaman Bruce
Принадлежит: Evello International, LLC

A oil extraction method includes performing grinding assisted extraction in the presence of solvent, co-solvent extraction with subcritical COcomprising, degassing the COand separating the mixture by centrifugation. 1cannabis. A oil extraction method , the method comprising: 'grinding plant material in the presence of solvent;', 'performing grinding assisted extraction comprising{'sub': '2', 'claim-text': {'sub': 2', '2, 'adding liquid COto the mixture, wherein the mixture is maintained at a temperature and pressure combination sufficient to maintain the liquid COin a subcritical state;'}, 'performing co-solvent extraction using subcritical COcomprising{'sub': '2', 'degassing the CO; and'}separating the mixture by centrifugation.2. The method of claim 1 , wherein the plant material ground in the presence of the solvent is wet plant material.3. The method of claim 1 , wherein a ratio of solvent to plant material present during the grinding assisted extraction is greater than 1:1 on a weight basis.4. The method of claim 1 , wherein a ratio of solvent to plant material present during the grinding assisted extraction is greater than 2:1 on a weight basis.5. The method of claim 1 , wherein grinding the plant material in the presence of solvent comprises grinding the plant material to micron scale.6. The method of claim 5 , wherein the plant material is ground to less than 20 microns during grinding assisted extraction.7. The method of claim 1 , wherein the solvent is a food grade solvent.8. The method of claim 1 , wherein the solvent is a non-polar solvent.9. The method of claim 8 , wherein the non-polar solvent is selected from pentane claim 8 , hexane claim 8 , benzene claim 8 , toluene claim 8 , carbon tetrachloride claim 8 , benzene claim 8 , glycerol monooleate claim 8 , diethyl ether claim 8 , hexane claim 8 , methylene chloride claim 8 , carbon dioxide claim 8 , methane claim 8 , ethylene claim 8 , D-limonene claim 8 , olive oil claim 8 , soybean oil claim 8 , ...

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Номер записи: 82
20-02-2020 дата публикации

Medicinal Composition of Extract of Seed of Emblica Officinalis and Method of Preparing the Same

Номер: US20200056522A1
Автор: Benny Antony
Принадлежит: Individual

A composition having an extract of seed of Emblica officinalis. Methods of preparing extract of seed of Emblica officinalis. An amla seed blend composition having various ratios of extracts of seeds of Emblica officinalis. Nutraceutical or pharmaceutical methods for decreasing the total cholesterol, decreasing triglyceride, decreasing blood glucose level, enhancing HDL-C levels, increasing the HDL-C level to total cholesterol ratio, lowering LDL-C levels, decreasing the CRP level, decreasing the intima media thickening, reducing hair fall in mammals especially human beings. The extract of seed of Emblica officinalis, or the amla seed blend composition is more effective compared to extracts prepared from fruits of Emblica officinalis.

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Номер записи: 83
28-02-2019 дата публикации

DEODORANT PRODUCTION METHOD AND DEODORANT

Номер: US20190060215A1
Автор: ISHII Sayaka, ISHII Yoichi, Okamoto Takeshi
Принадлежит: WELL STONE CO.

Provided are: a method for producing a deodorant which is derived from earthworm castings and can be used in a liquid form; and a deodorant. The deodorant production method characterized by including a mixing step of mixing earthworm castings with water and a collecting step of collecting vaporized water generated from a mixture obtained in the mixing step to obtain a liquid; and the deodorant produced by the production method. It is preferred to further mix an organic substance together with the earthworm castings and the water in the mixing step. 1. A deodorant production method comprising:a mixing step of mixing earthworm castings with water; anda collecting step of collecting vaporized water generated from a mixture obtained in the mixing step to obtain a liquid.2. The deodorant production method according to claim 1 , wherein an organic substance is further mixed together with the earthworm castings and the water in the mixing step.3. The deodorant production method according to claim 2 , wherein the organic substance is a wood material.4. The deodorant production method according to claim 1 , further comprising a diluting step of diluting the liquid obtained by the collection of the vaporized water in the collecting step with water.5. A deodorant produced by the deodorant production method as recited in .6. A deodorant produced by the deodorant production method as recited in .7. A deodorant produced by the deodorant production method as recited in .8. A deodorant produced by the deodorant production method as recited in . The present invention relates to: a method for producing a deodorant which is derived from earthworm castings and can be used in a liquid form; and a deodorant produced by the production method.As one of utilization methods for earthworm castings, a deodorant is known (see, for example, Patent Documents 1 to 3). It is believed that the odor eliminating effect of earthworm castings is brought about by the fact that earthworm castings have a ...

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Номер записи: 84
28-02-2019 дата публикации

OPTIMUM RATIO FOR HERBS COMBINATION OBTAINED BY USING SCIENTIFIC-BASED FORMULA FOR HYPERTENSION TREATMENT AND A COMPOSITION THEREOF

Номер: US20190060386A1
Автор: Loh Yean Chun, Yam Mun Fei
Принадлежит:

The present invention relates to a hypertension treatment. More particularly, the present invention relates to combination of four herbs' extract including 95% ethanolic extract of (UR95), 95% ethanolic extract of (PT95), 95% ethanolic extract of (PN95), and 50% ethanolic extract of (AO50) in particular range of ratio (known as F1 ratio), and all the raw herbs were then extracted in total by using 50% ethanol (known as F1-2) for use in a medicament for treating hypertension and hypertension-related complications and a composition thereof. 1. A method for obtaining a composition for use in a medicament for treating hypertension and hypertension-related complications , characterized in that , the method comprising steps of:{'i': Uncaria', 'Pueraria', 'Panax notoginseng,', 'Alisma orientale;, 'i. drying spp., spp., and'}{'i': Uncaria', 'Pueraria', 'Panax notoginseng,', 'Alisma orientale, 'ii. grinding dried spp., spp., and into powder;'}{'i': Uncaria', 'Pueraria', 'Panax notoginseng,', 'Alisma orientale', 'Uncaria', 'Pueraria', 'Panax notoginseng,', 'Alisma orientale, 'iii. mixing grounded spp., spp., and into a mixture wherein the grounded spp., spp., and is mixed in a ratio ranging from 2.32-7.35:0.44-4.44:7.24-11.24:0-3 respectively;'}iv. subjecting the mixture to an extraction method selected from a group comprising maceration, liquid-liquid extraction, decoction, solid-phase extraction, solid-phase microextraction, Soxhlet extraction, and fizzy extraction; andv. separating an extract containing the composition from mixture.2UncariaPuerariaPanax notoginseng,Alisma orientale. The method according to claim 1 , wherein the Spp. claim 1 , spp. claim 1 , and are prepared in effective concentration of EC claim 1 , EC claim 1 , EC claim 1 , and EC claim 1 , respectively.3UncariaPuerariaPanax notoginsengAlisma orientale. The method according to claim 1 , wherein the ratio of the grounded spp. to spp. to to is 5.32:2.44:9.24:1 respectively.4UncariaUncaria ...

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Номер записи: 85
17-03-2022 дата публикации

MANGOSTEEN PERICARP EXTRACT AND PROCESS FOR ITS PREPARATION THEREOF

Номер: US20220080014A1
Автор: Chen Chia-Wen, Chen Yen-Ting, CHEN YIN-JUN, HSIEH RONG-HONG
Принадлежит:

The present invention discloses a mangosteen pericarp extract and process for its preparation thereof. The mangosteen pericarp extract containing α-mangostin and γ-mangostin which obtains from preparation steps comprising fragmentation, organic solvent soaking, aqueous solution, or acidic solution soaking, concentration, spray drying and grinding steps from the rind of the mangosteen. The present invention has advantages of simple preparation process to address efficiency issue, no need to have heating under reflux in extraction steps and the solvents which used are friendly to human body and environment. 1. A process for preparing a mangosteen pericarp extract , said process comprising the following steps:drying and fragmenting the mangosteen pericarp to obtain fragment of mangosteen pericarp;soaking the fragment of mangosteen pericarp in organic solvent with a concentration of at least 70% and placing it at room temperature, and filtering it to obtain a mangosteen pericarp organic solvent extract, wherein the ratio of the weight to volume of the fragment of mangosteen pericarp and the organic solvent is 1:2 to 1:20;soaking and heating the fragment of mangosteen pericarp obtained from the previous step in aqueous solution and placing it at room temperature, and filtering it to obtain a mangosteen pericarp aqueous extract and a mangosteen pericarp residue, wherein the ratio of the weight to volume of the fragment of mangosteen pericarp and the aqueous solution is 1:10 to 1:20;concentrating the mangosteen pericarp organic solvent extract and the mangosteen pericarp aqueous extract to obtain a mangosteen pericarp organic solvent concentrate and a mangosteen pericarp aqueous concentrate; andspray drying the mangosteen pericarp organic solvent concentrate to obtain a α-Xones Extract, wherein the α-Xones Extract containing 10% to 30% of xanthone.2. The process defined in claim 1 , wherein said process further comprising the following steps:adding a first specific amount ...

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Номер записи: 86
17-03-2022 дата публикации

METHOD FOR PREPARING IRIDOID-RICH NONI FRUIT EXTRACT OR FRACTION THEREOF, METHOD FOR PREPARING IMMUNE-ENHANCING ACTIVE MATERIAL-RICH NONI FRUIT EXTRACT OR FRACTION THEREOF AND USE OF NONI FRUIT EXTRACT OR FRACTION THEREOF

Номер: US20220080018A1
Автор: CHOI Su Young, JANG Ji Hwan, JIN Bo Ra, KIM Hyun Ji, Kim Jin Hak
Принадлежит:

The present invention relates to a method of preparing a noni fruit extract containing a high iridoid content or a fraction thereof, a method of preparing a noni fruit extract containing a high content of an immune-enhancing active substance or a fraction thereof, and a use of a noni fruit extract or a fraction thereof, and more specifically, the present invention provides a method of preparing a noni fruit extract containing a high iridoid content or a fraction thereof, including preparing a noni fruit extract by using ethanol in a specific concentration range as an extraction solvent, a method of preparing a noni fruit extract containing a high content of an immune-enhancing active substance or a fraction thereof, a pharmaceutical composition for enhancing immunity including the extract or a fraction thereof, a health functional food composition including the same constitution, a method of enhancing immunity using the extract or a fraction thereof, and a use of the extract or a fraction thereof in preparation of medicine for preventing or treating a disease associated with immune enhancement or reduced immunity. 1. A method of preparing a noni fruit extract containing a high iridoid content or a fraction thereof , comprising:a) pulverizing noni fruit;b) injecting 10 (w/w) % to 60 (w/w) % ethanol of 5 to 15 times the weight of the pulverized product into the pulverized product; andc) preparing an extract by extracting at 60° C. to 100° C. for 1 hour to 8 hours.2. The method of claim 1 , wherein the ethanol in step b) is 20 (w/w) % to 60 (w/w) % ethanol.3. The method of claim 1 , wherein the extraction in step c) is stirring extraction.4. The method of claim 1 , further comprising d) filtering and concentrating the extract to prepare a concentrated solution.5. The method of claim 1 , wherein the iridoid is one or more selected from the group consisting of deacetylasperulosidic acid (DAA) claim 1 , asperulosidic acid (ASPA) and asperuloside (ASP).613.-. (canceled)14. ...

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Номер записи: 87
27-02-2020 дата публикации

REACTION PLATFORM AND METHOD FOR MAKING POLLEN BASED MATERIALS AND USES THEREOF

Номер: US20200061126A1
Автор: Weir Iona
Принадлежит:

A fermented pollen-based composition is provided which is made by treating pollen grains with one or more natural potassium sources selected from coconut water, coconut milk, raw honey, or honeydew honey, to naturally stimulate germination of the pollen, then incubating the germinated pollen, optionally with one or more additional components selected from beeswax, oils, enzyme-containing components derived from fruit, and probiotic components, wherein the resulting composition comprises a plurality of bioactive components selected from low molecular weight peptides, fatty acids, esterified flavonoids, dicaffeoyl quinic acid isomers and dicaffeoyl tartaric acid ester or ether compounds. Topical skin compositions including the fermented pollen-based composition as an active ingredient are also provided. 120.-. (canceled)21. A fermented pollen-based composition made by a process comprisingtreating pollen grains with one or more natural potassium sources selected from the group consisting of coconut water, coconut milk, raw honey, or honeydew honey, to naturally stimulate germination of the pollen to form a germinated pollen, thenincubating the germinated pollen,wherein the resulting composition after the step of incubating comprises a plurality of bioactive components selected from low molecular weight peptides, fatty acids, esterified flavonoids, dicaffeoyl quinic acid isomers and dicaffeoyl tartaric acid ester or ether compounds.22. The fermented pollen-based composition of claim 21 , wherein the germinated pollen is incubated with one or more additional components selected from beeswax claim 21 , oils claim 21 , enzyme-containing components derived from fruit claim 21 , and probiotic components.23. The fermented pollen-based composition of claim 21 , wherein the composition is freeze dried or spray dried.24. The fermented pollen-based composition of claim 21 , wherein the dicaffeoyl quinic acid isomers are selected from the group comprising 1 claim 21 ,3-diCQA claim ...

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Номер записи: 88
09-03-2017 дата публикации

COMPOSITIONS CONTAINING AS THE ACTIVE INGREDIENT COMPONENTS FROM SALVIA SCLAREA SEED

Номер: US20170065546A1
Автор: CHAIMOVITSH David, DUDAI Nativ, PUTIEVSKY Eli, SAADI Diah, SCHAFFERMAN Dan, YANIV BACHARACH Zohara
Принадлежит:

The present invention concerns a food supplement comprising seeds, or flour, oil or pulp or extracts obtained from the seeds as well as finished food products comprising the food supplement. The present invention further concerns a nutraceutical or cosmetic preparation comprising as an active ingredient seeds, or flour, oil or pulp or extracts obtained from the seeds. 121-. (canceled)22. A method of preventing wrinkling of skin or ensuring skin health in a subject , comprising:{'i': 'Salvia sclarea', 'topically applying to the subject a therapeutically effective amount of a cosmetic composition comprising seed oil.'}23. A therapeutic method of increasing the level of omega-3 fatty acid in a subject , comprising:{'i': Salvia sclarea', 'Salvia sclarea', 'Salvia sclarea, 'administering to the subject a therapeutically effective amount of a product selected from the group consisting of seed, seed oil, and seed crushed or milled to form a flour or powder.'}24. A therapeutic method of treating a subject suffering from a disease or condition which is known scientifically , or is discovered empirically , to benefit from an increase in the level of omega-3 fatty acid , comprising:{'i': Salvia sclarea', 'Salvia sclarea', 'Salvia sclarea, 'orally administering to the subject an effective amount of a product selected from the group consisting of seed, seed oil, and seed crushed or milled to form a flour or powder.'}25Salvia sclarea. In a method for relieving the symptoms of psoriasis in a subject , comprising topically administering to the affected area of the subject an effective amount of a composition comprising omega-3 fatty acids , the improvement wherein said composition comprises seed oil.26. A method in accordance with claim 24 , wherein said disease or condition is coronary artery disease. The present invention relates to food supplements and nutraceutical compositions for raising omega-3 levels in a subject.Current research in nutritional medicine indicates that the ...

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Номер записи: 89
09-03-2017 дата публикации

MUTANT TOMATOES AND USE THEREOF FOR PREVENTING WEIGHT GAIN AND/OR TREATING OBESITY-RELATED CONDITIONS

Номер: US20170065655A1
Автор: VAN DER WINDT ARIE-DIRK
Принадлежит:

The invention relates to the use of tomatoes for inhibition, amelioration or prevention of adipogenesis mediated diseases such as obesity, lipid storage disease and hyperlipemia. Provided is a tomato plant, fruit, fragment or extract thereof for use in a method for preventing weight gain, and/or inhibiting, preventing or ameliorating a disease condition associated with adipogenesis in a mammal, wherein the tomato is a ripening-impaired mutant tomato, such as a ripening inhibitor (rin), nonripening (nor), and/or never ripe (Nr) gene mutant tomato. Also provided are anti-adipogenic extracts and compositions comprising the extract. 118-. (canceled)19. A method for preventing weight gain , inhibiting , preventing or ameliorating a disease condition associated with adipogenesis in a mammal , wherein the method comprises the step of:administering to the mammal an extract of pericarp or root of a ripening-impaired mutant tomato having a rin, nor, or Nr content of at least 50 percent, wherein the extract is an anti-adipogenic agent.20. The method according to claim 19 , wherein the extract further comprises a prebiotic.21. The method according to claim 19 , wherein the tomato carries the rin gene claim 19 , wherein the rin content is at least 70 percent.22. The method according to claim 21 , wherein the tomato is a rin homozygote.23. The method according to claim 21 , wherein the tomato is selected from the group consisting of the varieties Slimmy claim 21 , Mr. Tasty claim 21 , Gusto Delight claim 21 , and Tomango.24. The method according to claim 20 , wherein the prebiotic is at least two of the group consisting of fructo-oligosaccharides claim 20 , galacto-oligosaccharides claim 20 , and xylo-oligosaccharides.25. The method according to claim 24 , wherein the extract is prepared by alcoholic extraction.26025. The method according to claim 19 , wherein the mammal is a human individual claim 19 , wherein the extract is prepared with at least . gram of the pericarp or root ...

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Номер записи: 90
11-03-2021 дата публикации

COMPOSITE NANOPARTICLE, PREPARATION METHOD THEREOF AND PREPARATION METHOD OF COMPOSITE NANO PREPARATION USING THEREOF

Номер: US20210069120A1
Автор: CAI Yu, DU Manling, HUANG Qingqing, LI Qianwen, MA Qianqian, WANG Bingyue, Yang Li, Zhang Ronghua
Принадлежит: Jinan University

A composite nanoparticle, a preparation method thereof and preparation method of a composite nano preparation using thereof, wherein the composite nanoparticle is a polymer-lipid nanoparticle encapsulating psoralen, isopsoralen and paclitaxel simultaneously, and the preparation method thereof comprises the following steps of: S1. dissolving soybean lecithin and DSPE-PEG2000 in an aqueous phase, subjected to blending and preheating; and S2. dissolving psoralen, isopsoralen, paclitaxel and PLGA in an oleic phase, subjected to blending and injecting into the aqueous phase of S1 to obtain a mixture, and then heating and blending the mixture to obtain the composite nanoparticle. 1. A composite nanoparticle , wherein the composite nanoparticle is a polymer-lipid nanoparticle encapsulating psoralen , isopsoralen and paclitaxel simultaneously.2. The composite nanoparticle according to claim 1 , wherein the composite nanoparticle has a particle diameter of 96.89±2.12 nm.3. A preparation method of the composite nanoparticle according to claim 1 , comprising the following steps of:S1. dissolving soybean lecithin and DSPE-PEG2000 in an aqueous phase, subjected to blending and preheating; andS2. dissolving psoralen, isopsoralen, paclitaxel and PLGA in an oleic phase, subjected to blending and injecting into the aqueous phase of the S1 to obtain a mixture, and then heating and blending the mixture to obtain the composite nanoparticle.4. The preparation method according to claim 3 , wherein the aqueous phase is absolute ethyl alcohol.5. The preparation method according to claim 3 , wherein the oleic phase is acetonitrile.6. The preparation method according to claim 3 , wherein a mass ratio of the soybean lecithin to the DSPE-PEG2000 in the S1 is M:1 claim 3 , and M is 5 to 6.7. The preparation method according to claim 3 , wherein a mass ratio of the psoralen to the isopsoralen to the paclitaxel in the S2 is 2:2:1.8. The preparation method according to claim 3 , wherein the ...

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Номер записи: 91
11-03-2021 дата публикации

OPTIMIZING VOLATILE ENTOURAGES IN DRY FLOWERING PLANT MIXTURES

Номер: US20210069271A1
Автор: Backes Michael Dane
Принадлежит:

Novel plant products customized to provide a desired, consistent and stable Entourage of Interest (EOI) and processes for making and using the same are provided. 1cannabis. A plant product having a desired , consistent and stable entourage of interest (EOI) , the plant product comprising dried and chopped plant material substrate from one or more plant types and an introduced EOI extract , wherein volatile components of the EOI extract are stably maintained in the plant product.2. The plant product of claim 1 , wherein the amount of one or more volatile EOI components in the plant product is equal to or greater than the amount of the same one or more volatile EOI components found in the plant material from which the introduced EOI extract was made.3. The plant product of claim 1 , wherein the fresh plant material and introduced EOI extract are (a) from the same plant type harvested at the same time claim 1 , (b) from the same plant type harvested at different times claim 1 , or (c) from different plant types.4Cannabis sativa, Cannabis indicaCannabis ruderalis.. The plant product of claim 1 , wherein the plant type is claim 1 , or5. The plant product of claim 4 , wherein the plant type is hemp.6mimosaginseng. The plant product of claim 1 , wherein the plant type is selected from the group consisting of hops claim 1 , basil claim 1 , claim 1 , passionflower claim 1 , corn silk claim 1 , rose petals claim 1 , lotus leaf claim 1 , licorice root claim 1 , jasmine claim 1 , claim 1 , and red clover flowers.7. The plant product of claim 4 , wherein the volatile components of the EOI extract comprises monoterpenes.8. The plant product of claim 7 , wherein the plant product has a total terpene content of at least 3%.9. The plant product of claim 7 , wherein the monoterpenes comprise one or more of α-Pinene claim 7 , β-Pinene claim 7 , β-Myrcene claim 7 , α-Phellandrene claim 7 , Limonene claim 7 , β-Ocimene claim 7 , Terpinolene claim 7 , α-Terpineol claim 7 , Linalool claim ...

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Номер записи: 92
11-03-2021 дата публикации

TRADITIONAL CHINESE MEDICINE COMPOSITION FOR IMPROVING BONE HEALTH AND PREPARATION AND USES THEREOF

Номер: US20210069275A1
Автор: Li Li, Li Wenyu, Li Xin, WANG Shanglong, Zhang Zengliang, Zong Jiancheng, Zong Lei, Zou Shengcan
Принадлежит:

A traditional Chinese medicine composition includes 60%-80% by weight of extract, 15%-30% by weight of extract and 5%-10% by weight of extract. A method of preparing the traditional Chinese medicine composition is also provided. Uses of the traditional Chinese medicine composition in the prevention and/or treatment of osteoporosis are also provided. 1. A traditional Chinese medicine composition for improving bone health , comprising:{'i': 'Eucommia ulmoides', '60%-80% by weight of extract;'}{'i': 'Rhizoma Drynariae', '15%-30% by weight of extract; and'}{'i': 'Semen Cuscutae', '5%-10% by weight of extract.'}2. The traditional Chinese medicine composition of claim 1 , comprising:{'i': 'Eucommia ulmoides', '60%-70% by weight of extract;'}{'i': 'Rhizoma Drynariae', '20%-30% by weight of extract; and'}{'i': 'Semen Cuscutae', '8%-10% by weight of extract.'}3Eucommia ulmoidesRhizoma DrynariaeSemen CuscutaeEucommia ulmoides, Rhizoma DrynariaeSemen CuscutaeEucommia ulmoidesRhizoma DrynariaeSemen Cuscutae. The traditional Chinese medicine composition of claim 1 , wherein the extract claim 1 , the extract and the extract are separately extracted from and ; and the traditional Chinese medicine composition is prepared by compounding the extract claim 1 , the extract and the extract.4. A method of preparing the traditional Chinese medicine composition of claim 1 , comprising:{'i': Eucommia ulmoides, Rhizoma Drynariae', 'Semen Cuscutae', 'Eucommia ulmoides', 'Rhizoma Drynariae', 'Semen Cuscutae, 'subjecting and to extraction, purification, concentration and drying to produce extract, extract and extract, respectively; and'}{'i': Eucommia ulmoides', 'Rhizoma Drynariae', 'Semen Cuscutae, 'mixing the extract, the extract and the extract uniformly to produce the traditional Chinese medicine composition;'}wherein the method specifically comprises:{'i': Eucommia ulmoides, Rhizoma Drynariae', 'Semen Cuscutae', 'Eucommia ulmoides', 'Rhizoma Drynariae', 'Semen Cuscutae, '(1) subjecting and ...

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Номер записи: 93
17-03-2016 дата публикации

EXTRACT OF PASSIONFLOWER SEEDS AND COSMETIC, PHARMACEUTICAL, DERMATOLOGICAL AND NUTRACEUTICAL COMPOSITIONS COMPRISING SAME

Номер: US20160074312A1
Автор: BREDIF Stephanie, Debrock Sebastien, Garnier Sebastien, Leclere-Bienfait Sophie, Msika Philippe
Принадлежит:

The invention relates to a composition comprising an extract of passionflower seeds, and preferentially seeds. The composition is advantageously cosmetic, pharmaceutical, dermatological or nutraceutical. The subject matter of the invention is also a process for extracting an extract of passionflower seeds and preferentially seeds, and also the extract which can be obtained by means of said process. The invention also relates to such a composition or such an extract for use in the prevention or treatment of disorders or pathological conditions of the skin, of the mucous membranes or of the skin appendages, for use in the prevention or treatment of vascular disorders, for use for combating oxidative stress, or else for use in the prevention or treatment of adipose tissue modifications. Finally, the invention relates to a cosmetic care process for the skin, the skin appendages or the mucous membranes, with a view to improving, the condition thereof or the appearance thereof, consisting in administering such a composition or such an extract. 118-. (canceled)19. A composition comprising a peptide and sugar extract of passionflower seeds , as active agent , and if need be a suitable excipient , wherein the peptide and sugar extract is obtained by enzymatic hydrolysis , in the presence of at least one protease and at least one carbohydrase.20Passiflora incarnataPassiflora edulisPassiflora edulis.. The composition of claim 19 , wherein the passionflower is or claim 19 , in particular21. The composition according to claim 19 , wherein in the peptide and sugar extract the peptides have a size less than 3500 Da.22. The composition according to claim 19 , wherein in the peptide and sugar extract the weight ratio of peptides/sugars is greater than 0.75 and preferably between 1 and 2.23. The composition according to claim 22 , wherein the peptide and sugar extract comprises 20% to 70% by weight peptides.24. The composition according to claim 22 , wherein the peptide and sugar ...

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Номер записи: 94
24-03-2022 дата публикации

Method of Drying Botanicals

Номер: US20220088101A1
Автор: Young Eric
Принадлежит:

A method for drying to increase the useful life of botanicals and shorten the time to market after harvest of the botanicals. The method may include flash freezing the botanicals, at a desired optimal temperature range, soon after harvest. The method may include storing the frozen botanicals indefinitely prior to drying. The method may include drying the frozen botanicals using a lyophilizer at a desired optimal temperature and pressure. 1. A method comprising:harvesting a cannabis botanical having flowers and leaves;separating the leaves from the botanical;flash freezing the leaves to solidify moisture content contained therein; andsublimating the solidified moisture content from the flash frozen leaves to form substantially moisture free flash frozen leaves.2. The method of claim 1 , further comprising the step of:forming a mulch from the moisture free flash frozen leaves.3. The method of claim 2 , further comprising the step of:packaging the mulch into at least one container.4. The method of claim 1 , further comprising the step of:converting the sublimated moisture content to liquid form, said liquid form being comprised of water and terpene oil, said terpene oil being lighter in weight than said water.5. The method of claim 4 , further comprising the steps of:separating said terpene oil from said water; andcollecting said separated terpene oil.6. A method comprising:harvesting a cannabis botanical having leaves and flowers;separating the leaves from the botanical;forming a mulch from the leaves;flash freezing the mulch to solidify moisture content contained therein producing a flash frozen mulch; andsublimating the solidified moisture from the flash frozen mulch to form a substantially moisture free flash frozen mulch.7. The method of claim 6 , further comprising the step of;packaging the moisture free flash frozen mulch into at least one container.8. The method of claim 6 , further comprising the step of:converting the sublimated moisture content to liquid ...

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Номер записи: 95
24-03-2022 дата публикации

STRAIN FOR PRODUCING NATTOKINASE AND PRODUCTION METHOD THEREFOR

Номер: US20220088154A1
Автор: CAI Chunli, CHEN Hongrui, CHEN Jiepeng, CHEN Yufan, DUAN Lili, Hong Lin, HU Liusong, JI Yeyu, XU Zhikai
Принадлежит:

Disclosed are a strain for producing nattokinase and a production method therefor. In particular, the present invention involves a novel strain capable of producing nattokinase, i.e. natto ST-1086, deposited at the China General Microbiological Culture Collection Center under CGMCC No. 17895. The present invention further involves a method for producing a nattokinase product by means of using the novel strain CGMCC No. 17895 of the present application, wherein the resulting nattokinase product can be used as a drug for dissolving thrombi. The present invention further involves the use of the nattokinase product of the present application for preparing a composition for dissolving thrombi and in a method for treating thrombi. 1Bacillus subtilis. A natto strain , deposited at China General Microbiological Culture Collection Center under CGMCC No. 17895.2Bacillus subtilis. A method for producing a nattokinase product claim 1 , comprising culturing the natto strain according to in a medium to produce nattokinase in the medium.3. The method according to claim 2 , wherein the medium comprises a carbon source substance and a nitrogen source substance claim 2 , and the ratio of the carbon source substance to the nitrogen source substance is 10:1 to 1:2.4. The method according to claim 3 , wherein the carbon source substance is selected from one or more of glucose claim 3 , sucrose claim 3 , maltose claim 3 , fructose and glycerol.5. The method according to claim 3 , wherein the nitrogen source substance is selected from one or more of yeast powder claim 3 , peptone claim 3 , soybean powder and chickpea powder.6. The method according to claim 2 , wherein the medium further comprises an organic substance claim 2 , an inorganic substance claim 2 , or a mixture of an organic substance and an inorganic substance claim 2 , which promotes the growth of microorganisms and improves the yield of nattokinase.7. The method according to claim 6 , wherein the organic substance is one or ...

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Номер записи: 96
07-03-2019 дата публикации

METHOD FOR FOODBORNE PATHOGEN REDUCTION IN POULTRY

Номер: US20190070234A1
Автор: McINTYRE Donald, Mitchell Michael
Принадлежит: CAN TECHNOLOGIES, INC.

A method for introducing a fermented product to poultry to reduce foodborne pathogens. The fermented product contains functional metabolites produced by and is added at a particular ratio to the feed for the most effective results. 113-. (canceled)14. A method for improving weight gain in poultry which have been administered a coccidia vaccine , comprising the steps of:supplementing a feed with a fermentation product derived from a yeast to produce a total feed,{'i': 'Saccharomyces cerevisiae', 'wherein the fermentation product is derived at least partially from ; and'}wherein the fermentation product is added to the feed such that the fermentation product is between 0.004% and 0.2% of the weight of the total feed,and feeding the total feed to poultry, wherein the poultry have been administered a coccidia vaccination prior to feeding,wherein the body weight of the poultry after 16 days is greater than the body weight of control poultry which were administered a coccidia vaccine but not fed a total feed including the fermentation product.15. The method of claim 14 , wherein:{'i': 'Saccharomyces cerevisiae', 'the fermentation product comprises functional metabolites produced by a yeast.'}16. The method of claim 14 , wherein:the fermentation product has a crude protein content, a crude fat content, and a crude fiber content; and comprisesamino acids,potassium, phosphorous and calcium.1718-. (canceled)19. The method of claim 16 , wherein the crude protein content is a minimum of 12.0%.20. The method of claim 16 , wherein the crude fat content is a minimum of 1.2%.21. The method of claim 16 , wherein the crude fiber content is a maximum of 30.0%.22. The method of claim 16 , wherein the ash content of the fermentation product is a maximum of 10.8%.23. The method of claim 14 , wherein the amount of fermentation product added to the feed is about 0.125% of the total feed.24. The method of claim 14 , wherein the poultry is not administered an antibiotic after coccidia ...

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Номер записи: 97
07-03-2019 дата публикации

TRADITIONAL CHINESE MEDICINE COMPOSITION AND USE THEREOF

Номер: US20190070237A1
Автор: CONG Renhuai, HU Minghua, MA Chung Wah, MA Fangli, WANG Yuanyuan, Xiao Lingyun
Принадлежит: INFINITUS (CHINA) COMPANY LTD.

The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising GANODERMA polysaccharide, GRIFOLA FRONDOSA polysaccharide, ANGELICAE SINENSIS RADIX oil and CINNAMOMI CORTEX oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4 and CD8 cells in lymphocytes of the tumor stroma, increases body immune function, recovers normal immune surveillance function, decreases the expression rate of VEGF and TGF-β 1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor. 1. A traditional Chinese medicine composition , comprising GANODERMA polysaccharide , GRIFOLA FRONDOSA polysaccharide , ANGELICAE SINENSIS RADIX oil and CINNAMOMI CORTEX oil.2. The tradition Chinese medicine composition according to claim 1 , wherein the weight ratio of GANODERMA polysaccharide claim 1 , GRIFOLA FRONDOSA polysaccharide claim 1 , ANGELICAE SINENSIS RADIX oil and CINNAMOMI CORTEX oil is (1 to 5): (1 to 5): (1 to 5): (1 to 5).3. The tradition Chinese medicine composition according to claim 1 , wherein the weight ratio of GANODERMA polysaccharide claim 1 , GRIFOLA FRONDOSA polysaccharide claim 1 , ANGELICAE SINENSIS RADIX oil and CINNAMOMI CORTEX oil is (1 to 2): (1 to 2): (1 to 2): (1 to 2).4. The tradition Chinese medicine composition according to claim 1 , wherein the weight ratio of GANODERMA polysaccharide claim 1 , GRIFOLA FRONDOSA polysaccharide claim 1 , ANGELICAE SINENSIS RADIX oil and CINNAMOMI CORTEX oil is 1:1:1.5:1.5.5. The tradition Chinese medicine ...

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Номер записи: 98
07-03-2019 дата публикации

TRADITIONAL CHINESE MEDICINE COMPOSITION AND USE THEREOF

Номер: US20190070246A1
Автор: CONG Renhuai, HU Minghua, MA Chung Wah, MA Fangli, WANG Yuanyuan, Xiao Lingyun
Принадлежит: INFINITUS (CHINA) COMPANY LTD.

The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising polysaccharide, polysaccharide, oil and oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4 and CD8 cells in lymphocytes of the tumor stroma, increases body immune function, recovers normal immune surveillance function, decreases the expression rate of VEGF and TGF-β 1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor. 1LYCII FRUCTUSPOLYGONATI RHIZOMACARYOPHYLLI FLOSCINNAMOMI CORTEX. A traditional Chinese medicine composition , comprising polysaccharide , polysaccharide , oil and oil.2LYCII FRUCTUSPOLYGONATI RHIZOMACARYOPHYLLI FLOSCINNAMOMI CORTEX. The tradition Chinese medicine composition according to claim 1 , wherein the weight ratio of polysaccharide claim 1 , polysaccharide claim 1 , oil and oil is (1 to 5):(1 to 5):(1 to 5):(1 to 5).3LYCII FRUCTUSPOLYGONATI RHIZOMACARYOPHYLLI FLOSCINNAMOMI CORTEX. The tradition Chinese medicine composition according to claim 1 , wherein the weight ratio of polysaccharide claim 1 , polysaccharide claim 1 , oil and oil is (1 to 2):(1 to 2):(1 to 2):(1 to 2).4LYCII FRUCTUSPOLYGONATI RHIZOMACARYOPHYLLI FLOSCINNAMOMI CORTEX. The tradition Chinese medicine composition according to claim 1 , wherein the weight ratio of polysaccharide claim 1 , polysaccharide claim 1 , oil and oil is 1:1:1.5:1.5.5. The tradition Chinese medicine composition according to claim 1 , which is in the form of a health food or a medicine.6. The tradition ...

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Номер записи: 99
16-03-2017 дата публикации

EXTRACTS OF CYCLANTHERA PEDATA AND FORMULATIONS AND USES THEREOF

Номер: US20170071995A1
Автор: Díaz Rebolledo Alejandro Mario, Perez Rebolledo Carlos
Принадлежит:

The invention provides a method for extracting active therapeutic components from plant materials of the plant which comprises immersing said plant material containing active components and selected from the group consisting of fruits, flowers, leaves, stems, twigs, bark, wood, buds, seeds, roots, and pods in a solvent for a period of time of about 30 minutes to about 10 hours to achieve transfer of active components from the plant material to the solvent, separating the solvent containing active components from the plant material, and evaporating or distilling the solvent to produce a concentrated fraction containing active components. The invention further includes compositions and therapeutic formulations of such extracts to treat hypercholesterolemia and other high lipid related diseases. 1cyclanthera pedataCyclanthera pedata.. A solid-form extract derived from the fruit of plants produced by a process comprising the following steps: (1) immersing the fresh fruit from said plant in an aqueous solution , solution containing an organic peracid for a period of time of about 2 minutes to 10 minutes , (2) cutting the fruit into strips and removing the seeds and mucilage form said strips , (3) drying said strips at a temperature between 10° C. and 80° C.; (4) milling said strips to produce a powder having a size of about 1 nm to about 2-10 mm; (5) Obtaining a concentrated liquid extract by immersing the milled material in a polar solvent including water , water-alcohol mixtures , alcohols , ethers , hydrocarbons or other organic solvents or mixtures thereof for a period of time of about 30 minutes to about 15 days and perform an extraction process based on one or a combination of the following procedures: maceration , percolation , soxhlet extraction , microwave assisted extraction , ultrasound assisted extraction , accelerated solvent extraction , enhanced solvent extraction , pulse electric field assisted extraction and steam distillation; (6) concentrating said ...

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Номер записи: 100