16-01-2014 дата публикации
Номер: US20140018384A1
There is provided compounds of formula I, wherein Xto X, Rto R, Y, Yand L are as defined in the description, and pharmaceutically-acceptable salts thereof, which may be useful in the treatment and/or prophylaxis of autoimmune diseases, inflammatory (e.g. chronic inflammatory) diseases and/or other diseases that may benefit from production of ROS (reactive oxygen species) by a NADPH oxidase complex. 2. A compound as claimed in claim 1 , wherein:{'sup': 6', '7', 'n, 'at least one of Rand Ris present and represents —OR, or'}{'sup': 6', '7, 'sub': 1-4', '1-4', '1-3, 'Rand Rare both present and are linked together to form a —O—Calkylene-, —Calkylene-O— or —O—Calkylene-O— group.'}3. A compound as claimed in claim 2 , wherein:{'sup': 6', '7, 'sub': '1-3', 'Rand Rare both present and are linked together to form a —O—Calkylene-O— group.'}4. A compound as claimed in claim 1 , wherein:{'sup': 1', '2', '3', '4', '5', '6', '7', '8', '1', '4, 'X, X, Xand Xeach represents CR, CR, CR, CRrespectively or any one of Xto X, alternatively and independently represents N;'}{'sup': 1', '2', 'a', 'c', 'd', 'f', 'g', 'h', 'i', 'j', 'k', 'l', 'm', 'n', 'q', 'r', 's, 'sub': 2', '2', 'm', '2, 'Eand Eeach independently represent halogen, —R, —CN, C(O)N(R)R, —N(R)R, —N(R)C(O)R, —N(R)C(O)OR, NO, —N(R)S(O)—R, —OR, —S(O)Ror S(O)N(R)R; or'}{'sup': 1', '2, 'sub': 1-5', '1-4', '1-4', '1-3', '1-3, 'any two Eor Esubstituents, when adjacent to one another, may be linked to form a —Calkylene-, O—Calkylene-, —Calkylene-O— or a O—Calkylene-O— group, which groups are optionally substituted by one or more substituent selected from —F, Calkyl, optionally substituted by one or more —F, and ═O;'}{'sup': '1', 'sub': 2', '2', '3, 'Rrepresents hydrogen, -Me, -Et, —CHF, —CHFor —CF;'}{'sup': '2', 'Rrepresents hydrogen, -Me or -Et;'}{'sup': 3', '4', '3', '4, 'Rand Reach independently represents hydrogen or -Me, or Rand Rmay be linked to form a further 3- to 4-membered ring;'}{'sup': 5', '6', '7', '8', 'a', 'c', 'd', 'f ...
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