20-06-2013 дата публикации
Номер: US20130156756A1
Автор:
Bader Benjamin,
BRIEM Hans,
HOLTON Simon,
Koppitz Marcus,
Kosemund Dirk,
Lienau Philip,
Prechtl Stefan,
Prien Olaf,
Schirok Hartmut,
Schulze Volker,
Siemeister Gerhard,
STÖCKIGT Detlef,
Wengner Antje Margret
The present invention relates to substituted triazolopyridine compounds of general formula (I): in which R, R, R, R, and Rare as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease of uncontrolled cell growth, proliferation and/or survival as well as to the use of intermediate compounds for the preparation of said compounds. 2. The compound according to claim 1 , wherein:{'sup': '1', 'claim-text': 'which is substituted, one or more times, identically or differently, with a substituent selected from:', 'Rrepresents an aryl or heteroaryl group'}{'sup': 6', '6', '6', '6', '6', '6', '6', '6', '6', '6', '7', '6', '6', '7', '7', '6', '7', '6', '7', '6', '6', '7', '6', '6', '6', '6', '7', '6', '6', '6', '7', '6', '7', '6', '6', '6', '7', '6', '7', '7', '6', '6', '7, 'sub': 2', 'n', '2', 'm', '1', '6', '2', 'n', '2', 'p', '1', '6', '1', '6', '1', '6', '1', '6', '2', '2', '2', '2', '2, 'claim-text': and', {'sup': 'xy', 'which is optionally substituted, one or more times, identically or differently, with a substituent Rselected from, {'sub': 1', '6', '1', '6', '1', '6', '1', '6', '1', '6, 'sup': 8', '7', '8', '8', '8', '7, 'halo-, hydroxyl-, cyano-, C-C-alkyl-, halo-C-C-alkyl-, C-C-alkoxy-, halo-C-C-alkoxy-, hydroxy-C-C-alkyl-, —N(H)C(═O)R, —N(R)C(═O)R, —C(═O)N(H)R, —C(═O)NRR;'}], 'R—(CH)(CHOH)(CH)—, R—(C-C-alkoxy)-, R—(CH)(CHOH)(CH)—O—, R—(C-C-alkoxy-C-C-alkyl)-, R—(C-C-alkoxy-C-C-alkyl)-O—, R—O—, —C(═O)R, —C(═O)O—R, —OC(═O)—R, —N(H)C(═O)R, —N(R)C(═O)R, —N(H)C(═O)NRR, —N(R)C(═O)NRR, —NRR, —C(═O)N(H)R, —C(═O)NRR, R—S—, R—S(═O)—, R—S(═O)—, —N(H)S(═O)R, —N(R)S(═O)R, —S(═O)N(H)R, —S(═O)NRR, —N(H)S(═O)R, —N(R)S(═O)R, —S(═O)N(H)R, —S(═O)NRR, —S(═O)(═NR)R, —S(═O)(═NR)R, —N═S(═O)(R)R;'}or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a ...
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