13-04-2017 дата публикации
Номер: US20170101406A1
Автор:
Akkari Rhalid,
ALVEY Luke Jonathan,
BOCK Xavier Marie,
Claes Pieter Isabelle Roger,
COWART Marlon D.,
De Lemos Elsa,
Desroy Nicolas,
Duthion Béranger,
Gfesser Gregory A.,
Gosmini Romain Luc Marie,
HOUSSEMAN Christopher Gaëtan,
Jansen Koen Karel,
Ji Jianguo,
Kym Philip R.,
Lefrancois Jean-Michel,
MAMMOLITI Oscar,
MENET Christel Jeanne Marie,
NEWSOME Gregory John Robert,
Palisse Adeline Marie Elise,
Patel Sachin V,
Pizzonero Mathieu Rafaël,
Shrestha Anurupa,
Swift Elizabeth C.,
VAN DER PLAS Steven Emiel,
Wang Xueqing
Принадлежит:
The present invention provides for compounds of formula (I) 2. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein{'sup': 1', '1A', '1B', '1C, 'sub': 1', '6', '1', '6, 'Ris G, -G-G, C-Chaloalkyl, or C-Calkyl.'}3. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein{'sup': 1', '1A, 'Ris G.'}4. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein{'sup': 1', '1B', '1C, 'Ris -G-G.'}5. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein{'sup': 2', '2xa', '2A, 'sub': 2', '4', '1', '6', '1', '6, 'Ris C-Calkenyl, C-Calkyl, C-Chaloalkyl, —OR, or G.'}6. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein{'sup': 2', '2A, 'sub': 1', '6', '1', '6, 'Ris C-Calkyl, C-Chaloalkyl, or G.'}7. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein{'sup': 3', '3A', '3B', '1', '3C', '3a', '3a', '3b, 'Ris G, -G-L-G, —OR, or —N(R)(R).'}8. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein{'sup': 1', '1A', '1B', '1C, 'Ris Gor -G-G; and'}{'sup': 2', '2xa', '2A, 'sub': 2', '4', '1', '6', '1', '6, 'Ris C-Calkenyl, C-Calkyl, C-Chaloalkyl, —OR, or G.'}9. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein{'sup': 1', '1A', '1B', '1C, 'Ris Gor G-G; and'}{'sup': 3', '3A', '3B', '1', '3C', '3a', '3a', '3b, 'Ris G, -G-L-G, —OR, or —N(R)(R).'}10. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein{'sup': 1', '1A', '1B', '1C, 'Ris Gor -G-G;'}{'sup': 2', '2xa', '2A, 'sub': 2', '4', '1', '6', '1', '6, 'Ris C-Calkenyl, C-Calkyl, C-Chaloalkyl, —OR, or G; and'}{'sup': 3', '3A', '3B', '1', '3C', '3a', '3a', '3b, 'Ris G, -G-L-G, —OR, or —N(R)(R).'}11. The compound of or a pharmaceutically acceptable salt thereof claim 10 , wherein{'sup': '1A', 'Gis optionally substituted phenyl or optionally substituted 5-6 membered monocyclic heteroaryl;'}{'sup': '2', 'sub': 1', '6, ...
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