23-05-2013 дата публикации
Номер: US20130129807A1
Принадлежит:
The disclosure provides collagen-based constructs for use in drug delivery. 1. A collagen-based , ultraviolet radiation crosslinked , film , wafer , or membrane construct comprising at least one layer of chemically derivatized collagen and an amount of an ophthalmic , otic , or nasal drug that has low water or aqueous solubility , wherein the amount of the drug is sufficient to provide a therapeutically effective amount of drug per day over a period of about six months , and further wherein the construct has been exposed to ultraviolet radiation crosslinking for a period of 17 to 19 minutes in a low oxygen environment.2. The collagen-based film claim 1 , wafer claim 1 , or membrane of claim 1 , wherein the drug present in the film claim 1 , wafer claim 1 , or membrane is resistant to removal by a 1 day treatment in an aqueous buffer.3. The collagen-based film claim 2 , wafer claim 2 , or membrane of claim 2 , wherein the drug present in the film claim 2 , wafer claim 2 , or membrane is resistant to removal by a 7 day treatment in an aqueous buffer.4. The film claim 2 , wafer claim 2 , or membrane of any one of to claim 2 , further comprising a barrier layer of collagen derivatized by an acylation agent.5. A collagen-based claim 2 , ultraviolet radiation crosslinked claim 2 , film claim 2 , wafer claim 2 , or membrane delivery system comprising at least one layer of glutaric anhydride-derivatized collagen and at least about 150 μg of Latanoprost claim 2 , wherein the film claim 2 , wafer claim 2 , or membrane has been crosslinked with ultraviolet radiation for from 17 to 19 minutes.6. The collagen-based film claim 5 , wafer claim 5 , or membrane of claim 5 , wherein the film claim 5 , wafer claim 5 , or membrane provides sustained and/or controlled release of about 1.5 μg Latanoprost per day for at least about 6 months but for less than one year.7. The film claim 5 , wafer claim 5 , or membrane delivery system of claim 5 , wherein the film claim 5 , wafer claim 5 , ...
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