03-02-2022 дата публикации
Номер: US20220033448A1
Принадлежит:
The present application belongs to the field of functional peptides and more particularly to the field of controlled protein aggregation. The invention discloses molecules of a peptide structure as defined in the claims and methods of using such molecules for therapeutic applications and for diagnostic uses, as well as in other applications such as in the agbio field and in industrial biotechnology. The molecules can be used for curing and/or stabilizing infections such as bacterial,fimgal and viral diseases, but are also useful in non-infectious human and veterinary diseases. The molecules can also be used for the detection of protein biomarkers and for the prognosis and diagnosis of a variety of diseases. 176.-. (canceled)77. A method for down-regulating the biological function of a protein , comprising [{'sub': 0', '1', '1', '2', '1', '3', '2', '4', '2', '1', '2, '(B) Z—X—Y—X—Z—X—Y—X—Z, wherein Zis a linker and Zis selected from a linker or nothing,'}, {'sub': 0', '1', '1', '2', '1', '3', '2', '4', '2', '5', '3', '6', '3', '1', '2', '3, '(C) Z—X—Y—X—Z—X—Y—X—Z—X—Y—X—Z, wherein Zand Zare each independently a linker and Zis selected from a linker or nothing,'}, {'sub': 0', '1', '1', '2', '1', '3', '2', '4', '2', '5', '3', '6', '3', '7', '4', '8', '4', '1', '2', '3', '4, '(D) Z—X—Y—X—Z—X—Y—X—Z—X—Y—X—Z—X—Y—X—Z, wherein Z, Z, and Zare each independently a linker and Zis selected from a linker or nothing,'}, {'sub': 0', '1', '1', '2', '1', '3', '2', '4', '2', '5', '3', '6', '0', '4', '8', '4', '0', '5', '10', '5', '1', '2', '3', '4', '5, '(E) Z—X—Y—X—Z—X—Y—X—Z—X—Y—X—Z—Y-X—Z—X—Y—X—Z, wherein Z, Z, Z, and Zare each independently a linker and Zis selected from a linker or nothing'}], '(a) contacting the protein with a molecule of structure (B), (C), (D), or (E) [{'sub': '0', 'Zis a linker or nothing,'}, {'sub': 1', '2', '3', '4', '5, 'at least one of Y, Y, Y, Y, and Yis identical to, or differs by 1 or 2 amino acid substitutions from, a stretch of contiguous amino acids ...
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