29-01-2015 дата публикации
Номер: US20150031603A1
Принадлежит:
A compound as represented by Formula (I) is provided, wherein groups are defined in the description. The compound is used as HCV protease inhibitor for treating HCV infection. 2. The compound according to claim 1 , wherein Ris —COR claim 1 , —CONRSOR claim 1 , —CONRSONRR claim 1 , or tetrazolyl.3. The compound according to claim 1 , wherein Ris —CONRSOR.4. The compound according to claim 1 , wherein Ris —COOR.6. The compound according to claim 1 , characterized in that Ris —CONRSORin Formula (IIa).7. The compound according to claim 1 , characterized in that Ris —COORin Formula (IIa).9. The compound according to claim 1 , characterized in that Ris —CONRSORin Formula (IIb).10. The compound according to claim 1 , characterized in that Ris —COORin Formula (IIb).11. The compound according to claim 1 , characterized in that the compound is selected from:{'sup': 4,7', '6,11, 'tert-butyl N-[(1R,12E,17S,20S,23S)-20-tert-butyl-23-{[(1R,2S)-1-[(cyclopropanesulfonyl)carbamoyl]-2-ethenylcyclopropyl]carbamoyl}-3,18,21-trioxo-2,15-dioxa-4,19,22-triazatetracyclo[20.2.1.1.0]hexacosa-6,8,10,12-tetraen-17-yl]carbamate;'}{'sup': 4,7', '6,11, '(1R,12E,17S,20S,23 S)-17-amino-20-tert-butyl-N-[(1R,2S)-1-[(cyclopropanesulfonyl)carbamoyl]-2-ethenylcyclopropyl]-3,18,21-trioxo-2,15-dioxa-4,19,22-triazatetracyclo[20.2.1.1.0]hexacosa-6,8,10,12-tetraene-23-carboxamide;'}{'sup': 4,7', '6,11, 'tert-butyl N-[(1R,12E,17R,20S,23S)-20-tert-butyl-23-{[(1R,2S)-1-[(cyclopropanesulfonyl)carbamoyl]-2-ethenylcyclopropyl]carbamoyl}-3,18,21-trioxo-2,15-dioxa-4,19,22-triazatetracyclo[20.2.1.1.0]hexacosa-6,8,10,12-tetraen-17-yl]carbamate;'}{'sup': 4,7', '6,11, '(1R,12E,17R,20S,23 S)-17-amino-20-tert-butyl-N-[(1R,2S)-1-[(cyclopropanesulfonyl)carbamoyl]-2-ethenylcyclopropyl]-3,18,21-trioxo-2,15-dioxa-4,19,22-triazatetracyclo[20.2.1.1.0]hexacosa-6,8,10,12-tetraene-23-carboxamide;'}{'sup': 4,7', '6,11, '(1R,12E,17S,20S,23 S)-20-tert-butyl-23-N-[(1R,2S)-1-[(cyclopropanesulfonyl)carbamoyl]-2-ethenylcyclopropyl]-3,18, ...
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