22-03-2012 дата публикации
Номер: US20120071450A1
Принадлежит:
Optionally substituted 4,5,7,8-tetrahydro-(optionally 4-thioxo or 4-imino)-(1H or 2H)-imidazo[1,2-a]pyrazolo[4,3-e]pyrimidine or 4,5,7,8,9-pentahydro-(optionally 4-thioxo or 4-imino)-(1H or 2H)-pyrimido[1,2-a]pyrazolo[4,3-e]pyrimidine compounds or Compounds of Formula (I), processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them. 1. An optionally substituted 4 ,5 ,7 ,8-tetrahydro-(optionally 4-thioxo or 4-imino)-(1H or 2H)-imidazo[1 ,2-a]pyrazolo[4 ,3-e]pyrimidine or 4 ,5 ,7 ,8 ,9-pentahydro-(1H or 2H)-pyrimido[1 ,2-a]pyrazolo[4 ,3-e]pyrimidine , in free or salt form.5. A pharmaceutical composition comprising a compound according to any of claim 20 , in admixture with a pharmaceutically acceptable diluent or carrier.6. A method of treating any of the following conditions: Parkinson's disease claim 20 , restless leg claim 20 , tremors claim 20 , dyskinesias claim 20 , Huntington's disease claim 20 , Alzheimer's disease claim 20 , and drug-induced movement disorders; depression claim 20 , attention deficit disorder claim 20 , attention deficit hyperactivity disorder claim 20 , bipolar illness claim 20 , anxiety claim 20 , sleep disorder claim 20 , narcolepsy claim 20 , cognitive impairment claim 20 , dementia claim 20 , Tourette's syndrome claim 20 , autism claim 20 , fragile X syndrome claim 20 , psychostimulant withdrawal claim 20 , and/or drug addiction; cerebrovascular disease claim 20 , stroke claim 20 , congestive heart disease claim 20 , hypertension claim 20 , pulmonary hypertension claim 20 , and/or sexual dysfunction; asthma claim 20 , chronic obstructive pulmonary disease claim 20 , and/or allergic rhinitis claim 20 , as well as autoimmune and inflammatory diseases; and/or female sexual dysfunction claim 20 , exercise amenorrhoea claim 20 , anovulation claim 20 , menopause claim 20 , menopausal symptoms claim 20 , hypothyroidism claim 20 , pre-menstrual syndrome claim 20 , premature labor claim 20 , ...
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