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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 527. Отображено 100.
12-01-2012 дата публикации

Binary-Weighted Delta-Sigma Fractional-N Frequency Synthesizer With Digital-To-Analog Differentiators Canceling Quantization Noise

Номер: US20120007643A1
Автор: Chang Mau-Chung Frank, Jian Heng-Yu, Wu Yi-Cheng, Xu Zhiwei
Принадлежит:

A phase lock loop includes a quantization circuit that generators an out of phase noise cancellation signal from an error in a delta-sigma modulator and applies the noise cancellation signal to the charge pump. The quantization circuit includes a digital-to-analog differentiator. The digital-to-analog differentiator may be, for example, a single-bit first-order digital-to-analog differentiator, a single-bit second-order digital-to-analog differentiator, or a full M-bit binary-weighted digital to analog differentiator. 1. A phase lock loop comprising:a phase frequency detector providing a phase detected signal in response to a reference frequency signal and a divided frequency signal;a charge pump providing a charge pump signal in response to the phase detected signal and a quantization error signal;a loop filter providing a filtered control signal in response to the charge pump signal;a voltage controlled oscillator for providing an output frequency signal in response to the filtered control signal;a fractional divider providing the divided frequency signal in response to the output frequency signal and a fraction selection signal;a delta-sigma modulator providing the fraction selection signal and an error signal in response to a divide selection signal; anda quantizer generating the quantization error signal in response to the error signal, the quantizer comprising a binary-weighted digital-to-analog differentiator.2. The phase lock loop of wherein the quantizer generators an error signal from amplitude or phase modulation that is applied as an opposed current pulse in the quantization error signal.3. The phase lock loop of wherein the delta-sigma modulator is an L-th order MASH delta-sigma modulator claim 1 , the quantizer quantizes the error signal claim 1 , and multiples the quantized error signal by a factor (1−z).4. The phase lock loop of wherein the delta-sigma modulator is a MASH-111 delta-sigma modulator.5. The phase lock loop of wherein the quantizer ...

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Номер записи: 1
02-02-2012 дата публикации

Amphiphilic polysiloxane prepolymers and uses thereof

Номер: US20120029111A1
Автор: Arturo N. Medina, Dawn A. Smith, Frank Chang, Jinyu Huang, John Dallas Pruitt, Laura Ann Sanders, Robert Scott
Принадлежит: Individual

The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses.

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Номер записи: 2
15-03-2012 дата публикации

SILICONE-CONTAINING POLYMERIC MATERIALS WITH HYDROLYZABLE GROUPS

Номер: US20120065331A1
Автор: Chang Frank, Chapoy L. Lawrence, Medina Arturo N., Quinn Michael Hugh, Smith Dawn A.
Принадлежит:

The invention provides a silicone hydrogel contact lens including a hydrolyzable units. The hydrolyzable units can be converted by hydrolysis into a hydrophilic units which is capable of imparting the silicone hydrogel contact lens a hydrophilic surface without post-curing surface treatment. The invention also provides an actinically crosslinkable prepolymer including hydrolyzable units and use of the prepolymer of the invention. In addition, the invention provides a method for making wettable silicone hydrogel contact lens without posterior surface treatments other than hydrolysis. 112-. (canceled)14. (canceled)15. The prepolymer of claim 13 , wherein the at least one vinylic monomer including a hydrolyzable silicone-containing group is a vinylic monomer of formula (1).16. The prepolymer of claim 13 , wherein the at least one vinylic monomer including a hydrolyzable silicone-containing group a vinylic monomer of formula (2).17. The prepolymer of claim 13 , wherein the hydrophilic vinylic monomer is selected from the group consisting of N claim 13 ,N-dimethylacrylamide (DMA) claim 13 , 2-hydroxyethylmethacrylate (HEMA) claim 13 , 2-hydroxyethyl acrylate (HEA) claim 13 , hydroxypropyl acrylate claim 13 , hydroxypropyl methacrylate (HPMA) claim 13 , trimethylammonium 2-hydroxy propylmethacrylate hydrochloride claim 13 , Aminopropyl methacrylate hydrochloride claim 13 , dimethylaminoethyl methacrylate (DMAEMA) claim 13 , glycerol methacrylate (GMA) claim 13 , N-vinyl-2-pyrrolidone (NVP) claim 13 , dimethylaminoethylmethacrylamide claim 13 , acrylamide claim 13 , methacrylamide claim 13 , allyl alcohol claim 13 , vinylpyridine claim 13 , N-(1 claim 13 ,1dimethyl-3-oxobutyl)acrylamide claim 13 , acrylic acid claim 13 , a C-C-alkoxy polyethylene glycol (meth)acrylate having a weight average molecular weight of from 200 to 1500 claim 13 , methacrylic acid claim 13 , N-vinyl formamide claim 13 , N-vinyl acetamide claim 13 , N-vinyl isopropylamide claim 13 , N-vinyl-N-methyl ...

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Номер записи: 3
05-04-2012 дата публикации

Milli-meter-wave-wireless-interconnect (m2w2 - interconnect) method for short-range communications with ultra-high data capability

Номер: US20120082194A1
Автор: Mau-Chung Frank Chang, Sai-Wang Tam
Принадлежит: UNIVERSITY OF CALIFORNIA

A millimeter wave wireless (M2W2) interconnect is used for transmitting and receiving signals at millimeter-wave frequencies for short-range wireless communication with high data rate capability. The transmitter and receiver antennae may comprise an on-chip differential dipole antenna or a bond wire differential dipole antenna. The bond wire differential dipole antenna is comprised of a pair of bond wires connecting between a pair of pads on an integrated circuit (IC) die and a pair of floating pads on a printed circuit board (PCB).

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Номер записи: 4
12-04-2012 дата публикации

POLYMERIZABLE CHAIN-EXTENDED POLYSILOXANES WITH PENDANT HYDROPHILIC GROUPS

Номер: US20120088843A1
Автор: Chang Frank, HUANG JINYU, Sanders Laura Ann
Принадлежит:

The invention provide a class of chain-extended polysiloxane crosslinkers which comprises (1) at least two polysiloxane segments, wherein each pair of adjacent polysiloxane segments is linked by one divalent organic radical which includes at least one pendant hydrophilic group (hydroxyl and/or carboxyl groups) or at least one dangling hydrophilic polymer chain and a di-thioether linkage —S-DR—S— in which DR is a divalent organic radical; and (2) two terminal ethylenically unsaturated groups. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer. 2. The chain-extended polysiloxane crosslinker of claim 1 , wherein BG is a linear or branched C-Calkylene divalent radical having at least one hydroxyl or carboxyl group or —OC(O)(CH)COOH in which t1 is an integer of 2 to 4 claim 1 , a divalent radical of —[CHCH(T)CHO]—[CH(R″)CHO]—[CHCH(T)CH]— in which R″ and r3 are as defined above claim 1 , T is hydroxyl or carboxyl group or —OC(O)(CH)COOH with t as defined above claim 1 , and r4 and r5 independent of each other are 0 or 1 claim 1 , or combinations thereof.4. The chain-extended polysiloxane crosslinker of claim 3 , wherein said at least one polysiloxane crosslinker comprises at least one hydroxyl group and is obtained by ethylenically-functionalizing of: (1) a di-epoxy terminated polysiloxane with use of an ethylenically-functionalizing vinylic monomer selected from the group consisting of Cto Chydroxylalkyl(meth)acrylate claim 3 , Cto Chydroxyalkyl(meth)acrylamide claim 3 , allyl alcohol claim 3 , allylamine claim 3 , amino-C-Calkyl(meth)acrylate claim 3 , C-Calkylamino-C-Calkyl (meth)acrylate claim 3 , vinylamine claim 3 , amino-C-Calkyl(meth)acrylamide claim 3 , C-Calkylamino-C-Calkyl(meth)acrylamide claim 3 , acrylic acid claim 3 , C-Calkylacrylic acid claim 3 , N-[tris(hydroxymethyl)-methyl]acrylamide claim 3 , N claim 3 ...

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Номер записи: 5
05-07-2012 дата публикации

METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES

Номер: US20120172478A1
Автор: Chang Frank, Domschke Angelika Maria, Holland Troy Vernon, Pruitt John Dallas, Qian Xinming, Smith Dawn A., Turek Richard Charles, Vogt Jürgen, Wu Daqing
Принадлежит:

The invention provide a method for making silicone hydrogel based on the Lightstream Technology from a monomer mixture with a curing time of less than about 100 seconds. The present invention is also related to silicone hydrogel contact lenses made according to methods of the invention. 117-. (canceled)18. A lens-forming composition suitable for making silicone hydrogel contact lenses according to a curing method based on a spatial limitation of actinic radiation , comprising: (1) from about 10% to about 50% by weight of at least one hydrophilic amide-type vinylic monomer; (2) from about 10% to about 40% by weight of at least one siloxane-containing vinylic monomer selected from the group consisting of siloxane-containing acrylate , siloxane-containing acrylamide , siloxane-containing methacrylamide; (3) from about 10% to about 40% by weight of a polysiloxane-containing vinylic macromer; (4) from about 0.1% to about 1.3% by weight of a photoinitiator , and (5) from 0 to about 5% by weight of a polymerizable UV-absorbing agent or a polymerizable latent UV-absorbing agent; wherein if one or more methacrylate monomers are present in the monomer mixture , the total amount of the methacrylate monomers is less than about 5% by weight , and wherein the lens forming composition is characterized by having a curing time of less than about 100 seconds by a UV light having an UV-intensity of about 4.1 mW/cm.21. The lens-forming composition of claim 19 , wherein the hydrophilic amide-type vinylic monomer is selected from the group consisting of 2-acrylamidoglycolic acid claim 19 , 2-acrylamido-2-methyl-1-propanesulfonic acid claim 19 , 2-acrylamido-2-methyl-1-propanesulfonic acid or salt thereof claim 19 , (3-acrylamidopropyl)trimethylammonium chloride claim 19 , 3-acryloylamino-1-propanol claim 19 , N-(butoxymethyl)acrylamide claim 19 , N-tert-butylacrylamide claim 19 , diacetone acrylamide claim 19 , N claim 19 ,N-dimethylacrylamide claim 19 , N claim 19 ,N- ...

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Номер записи: 6
19-07-2012 дата публикации

SERUM MARKERS ASSOCIATED WITH EARLY AND OTHER STAGES OF BREAST CANCER

Номер: US20120183555A1
Автор: Chang Frank N., Duong Phu T., Tuszynski George P.
Принадлежит: Temple University of the Commonwealth System of Higher Education

Methods for identifying disease-specific markers, in particular breast cancer markers, by electrophoretically separating serum albumin complexes in a biological sample on a membrane are provided. Electrophoretic separation profiles representing different diseases or different cancer stages can be produced, and used in the diagnosis, prognosis and treatment of these diseases. Methods for identification of a cancer peptide fragment comprising a cancer peptide motif are provided. Also provided are breast cancer and other cancer markers and antibodies that specifically recognize these markers. 1. An isolated breast cancer complex selected from the group consisting of Stage 0 Complexes , Stage I Complexes , Stage II Complexes , Stage III Complexes and Stage IV Complexes.2. The isolated breast cancer complex of claim 1 , comprising a cancer peptide fragment claim 1 , wherein the cancer peptide fragment comprises a cancer peptide motif having an amino acid sequence selected from SEQ ID NOs:1-122.3. The isolated breast cancer complex of claim 2 , wherein the cancer peptide fragment is the cancer peptide motif.4. The isolated breast cancer complex of claim 2 , wherein the cancer peptide motif has an amino acid sequence of SEQ ID NO: 44 or 46.517-. (canceled)18. A method of detecting a low copy number polypeptide in a biological sample claim 2 , comprising(a) obtaining the biological sample comprising a plurality of serum albumin complexes;(b) separating the serum albumin complexes on a membrane by a two-dimensional membrane electrophoresis;(c) digesting at least one separated serum albumin complex on the membrane with a protease; and(d) detecting the polypeptide in the digested complex.19. The method of claim 18 , wherein the polypeptide comprises a cancer peptide motif having an amino acid sequence selected from SEQ ID NOs: 1-122.20. The method of claim 18 , further comprising determining the amino acid sequence of the detected polypeptide.21. A kit for detecting a low copy ...

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Номер записи: 7
24-01-2013 дата публикации

CHEMICALLY TARGETED CONTROL OF DOWNHOLE FLOW CONTROL DEVICES

Номер: US20130020088A1
Автор: Ali Athar, CHANG FRANK F., CHEN Kuo-Chiang, DYER STEPHEN, Qiu Xiangdon
Принадлежит: SCHLUMBERGER TECHNOLOGY CORPORATION

Systems and methods using enhanced flow control devices are described. The flow control devices can be selectively closed completely or have its effective flow area reduced to restrict production (or injection) by use of a chemical trigger mechanism. In addition, some of the systems described herein deploy specific targeted chemical tracers, dissolvable in the unwanted production fluid (e.g. water or gas). These chemical tracers once dissolved will enter the production stream and be identified at the surface. The identification will determine which segment of the completion is producing the unwanted fluid. According to some embodiments, an appropriate chemical trigger is placed, for example, by pumping down through the tubing and utilizing intelligent completion valve to place the chemical, or by spotting with coiled tubing and bullhead to the formation, or by other methods of chemical placement. The chemical trigger will only trigger the active chemical in the appropriate flow control device. This chemical will then change state—dissolve, create thermal reaction, create a pressure swell or expand—which in turn allows a mechanical device to shift position such that a valve in the flow control device closes, or reduces its flow by restricting the flow area by swelling/expansion of the active chemical. 1. A method of chemically targeting control of flow control devices installed in a wellbore comprising:introducing a chemical into a wellbore having a plurality of flow control devices installed therein; andcausing actuation of a subset of the plurality of flow control devices with one or more chemical reactions due to the presence of the introduced chemical at the flow control device.2. A method according to wherein the plurality of flow control device includes three or more flow control devices.3. A method according to wherein each flow control device is an inflow control device that controls fluid flowing into the wellbore from a zone of a subterranean formation.4. A ...

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Номер записи: 8
21-02-2013 дата публикации

Compositions And Methods To Stabilize Acid-In-Oil Emulsions

Номер: US20130045899A1
Автор: Bustos Oscar, Chang Frank, Li Leiming, Samuel Mathew
Принадлежит: SCHLUMBERGER TECHNOLOGY CORPORATION

A method and apparatus for treating a subterranean formation traversed by a wellbore including forming an emulsion comprising oil, acid, and particulate, wherein the forming the emulsion is prepared on the fly, and introducing the emulsion into a wellbore. 1. A method for treating a subterranean formation traversed by a wellbore , comprising: oil,', 'acid, and', 'a water miscible nano and/or micro particulate,, 'forming an emulsion comprising'}wherein the forming the emulsion is prepared on the fly; andintroducing the emulsion into a wellbore.2. The method of claim 1 , wherein the particulate is a partially soluble organic acid or poly organic acid.3. The method of claim 1 , wherein the particulate is PLA claim 1 , PGA claim 1 , benzoic acid claim 1 , citric acid claim 1 , or a combination thereof.4. The method of claim 1 , wherein the acid comprises chelant-based acid system claim 1 , organic acids claim 1 , or a combination thereof.5. The method of claim 1 , wherein the acid comprises hydrofluoric claim 1 , hydrochloric claim 1 , formic claim 1 , acetic claim 1 , maleic claim 1 , citric claim 1 , or cinnamic acid or a combination thereof.6. The method of claim 1 , wherein the oil is diesel claim 1 , kerosene claim 1 , mineral oil claim 1 , paraffin oil claim 1 , vegetable oil claim 1 , LPG claim 1 , crude oil claim 1 , benzene claim 1 , xylene claim 1 , toluene claim 1 , or a mixture thereof.7. The method of claim 1 , wherein forming the emulsion is performed with a residence time of 30 seconds or less.8. The method in where the emulsion is partially created on the fly.9. The method in where the emulsion is fully created on the fly.10. The method of claim 1 , wherein the emulsion further comprises emulsifiers claim 1 , iron control agents claim 1 , HS scavenger claim 1 , fiber claim 1 , fluid loss additives claim 1 , friction reducers claim 1 , tacky additives claim 1 , consolidating materials claim 1 , scale control additives claim 1 , wettability alternating ...

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Номер записи: 9
04-07-2013 дата публикации

Novel Polymers

Номер: US20130172600A1
Автор: Chang Frank, Medina Norberto Arturo
Принадлежит: NOVARTIS AG

The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least two different hydrophilic monomers selected from the group consisting of N,N-dimethyl acrylamide (DMA), 2-hydroxyethyl acrylate (HEA), glycidyl methacrylate (GMA), N-vinylpyrrolidone (NVP), acrylic acid (AA) and a C-C-alkoxy polyethylene glycol(meth)acrylate having a weight average molecular weight of from 200 to 1500, and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group. 124-. (canceled)25. A process for manufacturing an actinically crosslinkable prepolymer , comprising:(1) obtaining a reaction mixture comprising a first hydrophilic monomer, at least one polysiloxane-containing crosslinker, a second hydrophilic monomer, and a chain transfer agent having a first functional group and present in an amount to have a desired initial concentration;(2) adjusting the temperature of the reaction mixture in order to start the polymerization reaction;(3) dosing the chain transfer agent to the reaction mixture at a rate sufficient to have a concentration comparable to the desired initial concentration until a desired total amount of the chain transfer agent is added;(4) following the completion of the chain transfer agent dosing maintaining the reaction mixture at the reaction temperature in order to complete the reaction so as to obtain a copolymerization product with first functional groups; and(5) reacting an organic compound with the copolymerization product to form the crosslinkable prepolymer having ethylenically unsaturated groups, wherein the organic compound comprises an ethylenically unsaturated group and a second functional group, wherein the second functional group of the organic compound reacts with one of the ...

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Номер записи: 10
18-07-2013 дата публикации

G-PROTEIN COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN 1 AS A CANCER BIOMARKER

Номер: US20130183317A1
Автор: Chang Frank N., Tuszynski George P.
Принадлежит: Temple University of the Commonwealth System of Higher Education

A method for determining whether early stage cancer is present in a subject comprises detecting the expression level of GASP-1 in the subject by detecting the amount of GASP-1 peptide fragments present in a biological sample of the subject. Because cancer can be detected at an early stage, therapeutic targeting may be initiated before cancer reaches late stage (e.g., before the development of overt symptoms). A method for treating early stage cancer in a subject comprises administering to the subject an effective amount of a GASP-1 inhibitor to inhibit the progression of early stage cancer to late stage cancer. A Competitive ELISA capable of detecting GASP-1 peptide fragments at a concentration of less than 1 ng/ml was developed. 1. A method for determining whether early stage cancer is present in a subject comprising:detecting the expression level of GASP-1 nucleic acid in a biological sample of the subject,wherein the subject has not been diagnosed with late stage cancer,wherein a higher expression level of GASP-1 nucleic acid in the subject compared to the expression level of GASP-1 in a cancer-free subject or a cancer-free biological sample indicates the presence of early stage cancer in the subject.2. The method of claim 1 , wherein the step of detecting the expression level of GASP-1 nucleic acid comprises determining the amount of GASP-1 mRNA in the sample.3. The method of claim 2 , wherein the amount of GASP-1 mRNA in the sample is determined by RT-qPCR or qPCR.4. The method of claim 1 , comprising comparing the expression level of GASP-1 mRNA in the subject to the expression level of GASP-1 mRNA in a cancer-free subject.5. The method of claim 1 , wherein the step of detecting the expression level of GASP-1 nucleic acid comprises determining the amount of GASP-1 cDNA in the sample.6. The method of claim 5 , wherein the amount of GASP-1 cDNA in the sample is determined by Immuno-PCR (IPCR).7. The method of claim 5 , wherein the amount of GASP-1 cDNA in the ...

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Номер записи: 11
10-10-2013 дата публикации

PERIODIC NEAR FIELD DIRECTORS (PNFD) FOR SHORT-RANGE MILLI-METER-WAVE-WIRELESS-INTERCONNECT (M2W2-INTERCONNECT)

Номер: US20130266048A1
Автор: Chang Mau-Chung Frank, Tam Sai-Wang
Принадлежит: The Regents of the University of California

Periodic near field directors (PNFD) are coupled to a transmitter and a receiver for a short-range millimeter wave wireless (M2W2) interconnect for transmitting and receiving radio frequency (RF) signals at millimeter-wave frequencies for short-range communication with high data rate capability between the transmitter and receiver. Each of the periodic near field directors is comprised of one or more periodic coupling structures (PSCs), wherein the periodic coupling structures are comprised of metallic strips positioned such that their lengthwise dimension is substantially perpendicular to a propagation direction of the radio frequency signals between the transmitter and receiver. Each of the periodic coupling structures is positioned parallel to adjacent periodic coupling structures with a separation distance between each periodic coupling structure being within one wavelength of the radio frequency signal. The periodic near field directors may include first and second periodic near field directors that are coupled to each other for transmitting and receiving the radio frequency signals between the first and second periodic near field directors, wherein there is an air gap between the first and second periodic near field directors. 1. A wireless interconnect for transmitting and receiving signals at specified frequencies for short-range communication with high data rate capability , comprising:one or more periodic near field directors (PNFDs) coupled to a transmitter and a receiver for a short-range millimeter wave wireless (M2W2) interconnect for transmitting and receiving radio frequency (RF) signals at millimeter-wave frequencies for short-range communication with high data rate capability between the transmitter and receiver.2. The wireless interconnect of claim 1 , wherein each of the periodic near field directors is comprised of one or more periodic coupling structures (PSCs).3. The wireless interconnect of claim 2 , wherein the periodic coupling structures ...

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Номер записи: 12
24-10-2013 дата публикации

Dielectric conduits for ehf communications

Номер: US20130278360A1
Автор: Emilio Sovero, Gary D. McCormack, Ian A. Kyles, Mau-Chung Frank Chang, Yanghyo Kim
Принадлежит: Keyssa Inc

Dielectric conduits for the propagation of electromagnetic EHF signals include an elongate body of a dielectric material extending continuously along a longitudinal axis between a first terminus and a second terminus. At each point along the longitudinal axis, an orthogonal cross-section of the elongate body has a first dimension along a major axis of the cross-section, where the major axis extends along the largest dimension of the cross-section. The orthogonal cross-section also has a second dimension along a minor axis of the cross-section, where the minor axis extends along a widest dimension of the cross-section that is at a right angle to the major axis. For each cross-section of the elongate body, the first dimension is greater than the wavelength of the electromagnetic EHF signals and the second dimension is less than the wavelength of the electromagnetic EHF signals.

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Номер записи: 13
21-11-2013 дата публикации

COMPOSITION AND METHOD FOR TREATING CARBONATE RESERVOIRS

Номер: US20130306320A1
Автор: AL-MUNTASHERI GHAITHAN A., ALOTAIBI MSALLI AWADH, CHANG FRANK F., Hussein Ibnelwaleed A.
Принадлежит:

The composition and method for treating carbonate reservoirs provides a treatment fluid for the acid treatment of stratified subterranean formations. The treatment fluid is injected into a non-problematic or high permeability zone of a carbonate reservoir. The treatment fluid is formed from a zwitterionic viscoelastic surfactant, which forms about 7.5 vol % of the treatment fluid, hydrochloric acid forming about 15.0 vol % of the treatment fluid, and a corrosion inhibitor forming about 0.6 vol % of the treatment fluid, the balance being brine. The treatment fluid gels as the hydrochloric acid reacts with carbonate of the carbonate reservoir, thus forming a diverting block in the non-problematic or high permeability zone. Following formation of the diverting block, a further volume of the treatment fluid is injected into the carbonate reservoir. The diverting block diverts the treatment fluid into a problematic or low permeability zone of the carbonate reservoir. 1. A composition for treating carbonate reservoirs , comprising:about 7.5 vol % zwitterionic viscoelastic surfactant;about 15.0 vol % hydrochloric acid; andabout 0.6 vol % corrosion inhibitor, the balance being brine.2. The composition for treating carbonate reservoirs as recited in claim 1 , wherein the zwitterionic viscoelastic surfactant comprises erucrylamidopropyl betaine.3. A method for treating a carbonate reservoir claim 1 , comprising the steps of:injecting a treatment fluid into a non-problematic zone of a carbonate reservoir, the treatment fluid comprising about 7.5 vol % zwitterionic viscoelastic surfactant, about 15.0 vol % hydrochloric acid, about 0.6 vol % corrosion inhibitor, the balance being brine;permitting the treatment fluid to gel as the hydrochloric acid reacts with carbonate of the carbonate reservoir, forming a diverting block in the non-problematic zone; andinjecting a further volume of the treatment fluid into the carbonate reservoir;whereby the diverting block diverts the ...

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Номер записи: 14
19-12-2013 дата публикации

AZETIDINIUM-CONTAINING COPOLYMERS AND USES THEREOF

Номер: US20130337160A1
Автор: Chang Frank, Chiang Chung-Yuan, Holland Troy Vernon, Kapoor Yash, Pruitt John Dallas, Qiu Yongxing, Scott Robert, Shankernarayanan Manivakkam J.
Принадлежит:

The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses. 2. An azetidinium-containing copolymer comprising azetidinium-containing monomeric units derived from at least one azetidinium-containing vinylic monomer of .3. The azetidinium-containing copolymer of claim 2 , further comprising monomeric units derived from at least one vinylic monomer selected from the group consisting of a carboxyl-containing vinylic monomer claim 2 , an amino-containing vinylic monomer claim 2 , a hydrophobic vinylic monomer claim 2 , and combination thereof claim 2 ,{'sub': 1', '4', '2', '4', '1', '4', '1', '12', '2', '6', '2', '6', '1', '12', '2', '12, 'wherein the carboxyl-containing vinylic monomer is selected from the group consisting of acrylic acid, a C-C-alkyl acrylic acid, N,N-2-acrylamidoglycolic acid, beta methyl-acrylic acid, alpha-phenyl acrylic acid, beta-acryloxy propionic acid, sorbic acid, angelic acid, cinnamic acid, 1-carobxy-4-phenyl butadiene-1,3, itaconic acid, citraconic acid, mesaconic acid, glutaconic acid, aconitic acid, maleic acid, fumaric acid, and combination thereof, wherein the amino-containing vinylic monomer is selected from the group consisting of amino-C-Calkyl(meth)acrylate, allylamine, vinylamine, amino-C-Calkyl(meth)acrylamide, N-allyl C-Calkanamine, a coupling reaction product of an epoxy compound having one sole epoxy group with allylamine, vinylamine, amino-C-Calkyl(meth)acrylate, or amino-C-Calkyl(meth)acrylamide, a coupling reaction product of an C-Calkanamine or C-Caminoalkanol or with an epoxy-containing vinylic monomer, and combinations thereof,'}wherein the hydrophobic vinylic monomer is selected from the group consisting of methyl(meth)acrylate, ethyl(meth)acrylate, propyl(meth)acrylate, isopropyl(meth)acrylate, butyl(meth)acrylate, sec-butyl(meth)acrylate, isobutyl(meth)acrylate, t-butyl(meth)acrylate, ...

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Номер записи: 15
02-01-2014 дата публикации

AMPHIPHILIC POLYSILOXANE PREPOLYMERS AND USES THEREOF

Номер: US20140005430A1
Автор: Chang Frank, HUANG JINYU, Medina Arturo N., Pruitt John Dallas, Sanders Laura A., Scott Robert, Smith Dawn A.
Принадлежит: NOVARTIS AG

The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses. 117-. (canceled)18. A partially ethylenically-functionalized polysiloxane , which is a mixture of reaction products obtained by reacting an ethylenically functionalizing vinylic monomer having a first reactive functional group with a linear functional polysiloxane compound having two terminal second reactive functional groups at a molar equivalent ratio , R , of from about 40% to about 97% , wherein each first reactive functional group reacts with one second reactive functional group in the presence or absence of a coupling agent to form a covalent bond or linkage , wherein the mixture of reaction product comprises (R)×100% by mole of a linear polysiloxane crosslinkers having two terminal ethylenically-unsaturated groups , 2×R×(1−R)×100% by mole of a polysiloxane vinylic monomer or macromer having one terminal second reactive functional group and one terminal ethylenically-unsaturated group , and (1−R)×(1−R)×100% by mole of unreacted linear polysiloxane compound with two terminal second reactive functional groups.19. The partially ethylenically-functionalized polysiloxane of claim 18 , wherein Ris from about 50% to about 95%.20. The ...

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Номер записи: 16
30-01-2014 дата публикации

REGENERATIVE RECEIVER ARCHITECTURES FOR MILLIMETER-WAVE AND SUB-MILLIMETER-WAVE IMAGING AND COMMUNICATION

Номер: US20140027638A1
Автор: Chang Mau-Chung Frank, Tang Adrian
Принадлежит: The Regents of the University of California

A millimeter and sub-millimeter wavelength receiver imaging apparatus and method which directly generates a time encoded digital signal for an imaging pixel in response to interoperation of a digital quench circuit, an envelope detector, and a regenerative oscillator coupled to an antenna. The device utilizes the fact that oscillator startup time in a regenerative oscillator is inversely proportional to injected pixel image power. A digital quench circuit, such as a latch, is coupled for activating and deactivating the regenerative oscillator in response to receiving an output from an envelope threshold circuit, and for generating a time encoded digital signal in response to pixel amplitude during millimeter and sub-millimeter wavelength imaging. Receiver embodiments are described for both fundamental frequency operation (DRR) and for multi-frequency imaging (IRR). 1. An apparatus for receiving millimeter and sub-millimeter wavelength imaging signals , said apparatus comprising:an antenna configured for receiving millimeter and sub-millimeter wavelengths;a regenerative oscillator circuit configured for oscillating at a first frequency in response to receiving a signal from said antenna;an envelope detector circuit coupled to an output of the regenerative oscillator circuit, said envelope detector circuit configured for generating a digital envelope threshold output in response to detecting that an oscillation envelope has reached a threshold; anda digital quench circuit coupled to said regenerative oscillator circuit, said digital quench circuit configured for activating and deactivating said regenerative oscillator in response to receiving said digital envelope threshold output, and for generating a time encoded digital signal in response to pixel amplitude during millimeter and sub-millimeter wavelength imaging.2. The apparatus as recited in claim 1 , wherein oscillator startup time in said regenerative oscillator circuit is inversely proportional to injected ...

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Номер записи: 17
27-02-2014 дата публикации

MATERIALS AND METHODS TO PREVENT FLUID LOSS IN SUBTERRANEAN FORMATIONS

Номер: US20140054039A1
Автор: ABBAD MUSTAPHA, CHANG FRANK F.
Принадлежит:

Methods of preventing fluid loss in a downhole formation may include preparing an emulsion containing: an oleaginous phase; an aqueous phase; one or more fibers; injecting the emulsion into the wellbore; allowing the one or more fibers within the emulsion to seal a permeable interval of the formation. In another aspect, methods of stimulating hydrocarbon production in a wellbore may include: injecting a diverting treatment into a subterranean formation, the diverting treatment containing: a non-oleaginous fluid, an oleaginous fluid, and one or more fibers; injecting a stimulating treatment into the subterranean formation; and stimulating the production of hydrocarbons. 1. A method of preventing fluid loss in a downhole formation , comprising: an oleaginous phase,', 'an aqueous phase,', 'one or more fibers; and, 'injecting the emulsion into the wellbore, the emulsion comprisingallowing the one or more fibers within the emulsion to seal a permeable interval of the downhole formation.2. The method of claim 1 , wherein the emulsion is a water-in-oil emulsion.3. The method of claim 1 , wherein the emulsion is an oil-in-water emulsion.4. The method of claim 1 , wherein the average length of the one or more fibers ranges from 100 μm to 20 mm.5. The method of claim 1 , wherein the one or more fibers are added at a concentration of 1 ppg to 15 ppg.6. The method of claim 1 , wherein the one or more fibers are oleophilic.7. The method of claim 6 , wherein the one or more fibers are selected from a group consisting of homopolymers claim 6 , copolymers claim 6 , multi-block interpolymers claim 6 , and higher order polymers of ethylene claim 6 , tetrafluoroethylene claim 6 , vinylidene fluoride claim 6 , propylene claim 6 , butene claim 6 , 1-butene claim 6 , 4-methyl-1-pentene claim 6 , styrene claim 6 , p-phenylene-2 claim 6 ,6-benzobisoxazole claim 6 , aramids claim 6 , and urethanes.8. The method of claim 1 , wherein the one or more fibers are hydrophilic.9. The method of ...

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Номер записи: 18
27-02-2014 дата публикации

METHODS TO ENHANCE MATRIX ACIDIZING IN LOW PERMEABILTY RESERVOIRS

Номер: US20140054040A1
Автор: CHANG FRANK F., ZHAO WEISHU
Принадлежит: SCHLUMBERGER TECHNOLOGY CORPORATION

The subject disclosure relates to matrix acidizing. More specifically, the subject disclosure relates to manipulating downhole pressure to promote in-situ mixing. In particular, downhole pressure is temporarily reduced to allow churning of the dissolved COto facilitate mixing efficiency within the wormholes and the matrix around the wormholes. 1. A method for acid treating a subterranean reservoir formation from a wellbore penetrating the formation , the method comprising:isolating a treatment zone of the formation;using pumping equipment, pumping an acidic fluid into the treatment zone of the formation so as to form a plurality of conductive channels extending from the wellbore into the formation; andcontrolling the pumping equipment so as to intentionally repeatedly decrease and increase pressure of the pumped acidic fluid so as to extend depths of the conductive channels into the formation.2. A method according to claim 1 , wherein the conductive channels are wormholes.3. A method according to claim 2 , wherein the decreasing and increasing pressure extends the depths of the conductive channels at least in part by enhancing in-situ fluid mixing near distal tips of the conductive channels.4. A method according to claim 1 , wherein fluid pressure is controlled so as not to cause fracturing of the formation.5. A method according to claim 1 , wherein controlling the pumping equipment includes varying a pumping speed.6. A method according to claim 1 , wherein controlling the pumping equipment includes repeatedly ceasing pumping.7. A method according to claim 1 , wherein controlling the pumping equipment includes repeatedly drawing down pressure in the formation.8. A method according to claim 1 , wherein the formation is a low-permeability formation.9. A method according to claim 1 , wherein the formation is a carbonate formation.10. A method according to claim 1 , wherein the acidic fluid contains hydrochloric acid.11. A system for acid treating a subterranean ...

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Номер записи: 19
27-02-2014 дата публикации

ESTIMATING DIFFUSION COEFFICIENT FOR A RESERVOIR STIMULATION FLUID

Номер: US20140057356A1
Автор: CHANG FRANK F., Qiu Xiangdong
Принадлежит: SCHLUMBERGER TECHNOLOGY CORPORATION

The subject disclosure relates to matrix acidizing. More specifically, systems and methods are described for estimating a diffusion coefficient for an acid fluid used to stimulate a subterranean reservoir wherein a spent acid is formulated that includes one or more by-products of the reaction between the fluid and rock. A rock sample, such as in the form of a rotating disk is exposed to spent acid under elevated pressure and temperature conditions while the fluid is sampled and analyzed. A diffusion coefficient for the spend acid is estimated. 1. A method of estimating a diffusion coefficient for a stimulation fluid used to stimulate a subterranean reservoir rock by at least partially dissolving the rock , the method comprising:generating a partially spent stimulation fluid comprising a stimulation fluid used to stimulate the subterranean reservoir rock and one or more reaction by-products, the reaction by-products being of a type produced during reaction of the stimulation fluid with the reservoir rock;in a sealed chamber, exposing a sample of reactant material to the partially spent stimulation fluid under elevated pressure conditions such that the reactant material reacts with the partially spent stimulation fluid; andmeasuring properties of the partially spent stimulation fluid after at least some of the reactant material has reacted with the partially spent stimulation fluid and estimating therefrom a diffusion coefficient for the stimulation fluid under partially spent downhole conditions.2. A method according to claim 1 , wherein the reservoir rock is a carbonate reservoir rock and the reaction by-products includes dissolved CO.3. A method according to claim 2 , wherein the reaction by-products further includes calcium ions.4. A method according to claim 2 , wherein the reaction by-products further includes magnesium ions.5. A method according to claim 1 , wherein the sample of reactant material is a solid rotating disk having a material found in the ...

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Номер записи: 20
10-04-2014 дата публикации

Actinically-Crosslinkable Siloxane-Containing Copolymers

Номер: US20140100291A1
Автор: Chang Frank, HUANG JINYU, Scott Robert, Wang Guigui
Принадлежит: NOVARTIS AG

The invention provide a class of actinically-crosslinkable silicone-containing prepolymers obtained by functionalizing an intermediary copolymer to have two or more thiol or ethylenically-unsaturated groups covalently attached thereto, wherein the intermediary copolymer is an atom-transfer radical polymerization (ATRP) product of a reactive mixture comprising a polysiloxane ATRP macroinitiator and at least one hydrophilic vinylic monomer. The present invention is also related to silicone hydrogel contact lenses made from a prepolymer of the invention and methods for making the contact lenses in a cost-effective way and with high consistency and high fidelity to the original lens design. 19-. (canceled)11. The contact lens of claim 10 , wherein the contact lens has at least one property selected from the group consisting of an oxygen permeability of at least about 40 barrers claim 10 , an elastic modulus of about 2.0 MPa or less claim 10 , an Ionoflux Diffusion Coefficient claim 10 , D claim 10 , of at least about 1.5×10mm/min claim 10 , and a water content of from about 15% to about 65%.12. The contact lens of claim 10 , wherein the lens-forming material comprises one or more components selected from the group consisting of a photoinitiator or thermal initiator claim 10 , a visibility tinting agent claim 10 , a polymerizable UV-absorbing agent claim 10 , a polymerizable latent UV-absorbing agent claim 10 , an antimicrobial agent claim 10 , a bioactive agent claim 10 , and a leachable lubricant.13. The contact lens of claim 10 , wherein the lens-forming material comprises one or more components selected from the group consisting of a hydrophilic vinylic monomer claim 10 , a silicone-containing vinylic monomer claim 10 , a hydrophobic vinylic monomer free of silicone atom claim 10 , a crosslinking agent.15. The contact lens of claim 10 , wherein LC is a divalent radical of a linear polymer chain of one or more hydrophilic vinylic monomers selected from the group ...

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Номер записи: 21
05-01-2017 дата публикации

TRIS(TRIMETHYL SILOXY)SILANE VINYLIC MONOMERS AND USES THEREOF

Номер: US20170002029A1
Автор: Chang Frank, Hagiwara Mamoru, ICHINOHE Shoji
Принадлежит:

The invention provides a TRIS-containing vinylic monomer which comprises one sole (meth)acryloyloxy group and a tris(trimethylsiloxy)silyl group covalently linked to the ethylenically-unsaturated group through a polyoxyethylene linker. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from a TRIS-containing vinylic monomer of the invention. In addition, the invention provides a method for making a TRIS-containing vinylic monomer of the invention. 17-. (canceled)9. The method of claim 8 , wherein the step of reacting is carried out in a solvent that is a ketone solvent.10. The method of claim 8 , wherein the catalyst is an amine catalysts claim 8 , a tin catalyst claim 8 , and/or an iron catalyst.11. The method of claim 8 , wherein the catalyst is present in an amount of about 10 to about 1 claim 8 ,000 ppm based on the total weight of the polyoxyethylene (meth)acrylate of formula (II) and the isocyanatoalkyl tris(trimethylsiloxy) silane of formula (III).12. The method of claim 8 , wherein the step of reacting is carried out by charging the polyoxyethylen (meth)acrylate of formula (II) claim 8 , the isocyanatoalkyl tris(trimethylsiloxy) silane of formula (III) and a reaction solvent in a reactor and then adding a catalyst thereto to form a reaction mixture.13. The method of claim 8 , wherein the step of reacting is carried out by charging the polyoxyethylen (meth)acrylate of formula (II) claim 8 , a reaction solvent and a catalyst in a reactor claim 8 , whereupon the isocyanatoalkyl tris(trimethylsiloxy) silane of formula (III) is added dropwise to form a reaction mixture claim 8 , wherein the dropwise addition is started at a temperature of about −10° C. to about 30° C. claim 8 , and the internal temperature of the reaction mixture is controlled below 50° C. during dropwise addition.14. ...

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Номер записи: 22
07-01-2016 дата публикации

METHOD TO CREATE CONNECTIVITY BETWEEN WELLBORE AND FORMATION

Номер: US20160003015A1
Автор: CHANG Fakuen Frank
Принадлежит:

A jetting gun placed in a wellbore in a formation for penetrating the formation to create perforation tunnels comprising a pressure vessel, the pressure vessel comprising a propellant chamber and a nozzle, the pressure vessel configured to withstand a pressure of the wellbore, the nozzle embedded in the pressure vessel in a predetermined orientation, such that the propellant chamber is in fluid communication with the wellbore. The propellant chamber fully enclosed within the pressure vessel configured to hold a jetting fluid and an energetic material, wherein the energetic material is operable to generate pressure within the propellant chamber when activated such that the pressure projects the jetting fluid through the nozzle to create an impact fluid to penetrate the formation to create the perforation tunnels. The jetting gun also includes a detonating mechanism configured to activate the energetic material to generate the pressure within the propellant chamber. 1. A jetting gun placed in a wellbore in a formation for penetrating the formation to create perforation tunnels , the jetting gun comprising: the nozzle embedded in the pressure vessel in a predetermined orientation, such that the propellant chamber is in fluid communication with the wellbore, the nozzle having a cross-sectional shape; and', wherein the energetic material is operable to generate pressure within the propellant chamber such that the pressure is operable to project the jetting fluid through the nozzle to create an impact fluid, and', 'wherein the impact fluid is operable to penetrate the formation to create the perforation tunnels; and, 'the propellant chamber fully enclosed within the pressure vessel, the propellant chamber configured to hold a jetting fluid and an energetic material,'}], 'a pressure vessel, the pressure vessel comprising a propellant chamber and a nozzle, the pressure vessel configured to withstand a pressure of the wellbore;'}a detonating mechanism, the detonating ...

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Номер записи: 23
14-01-2021 дата публикации

HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF

Номер: US20210009743A1
Автор: Chang Frank, HUANG JINYU, Jing Feng, Zhang Steve Yun
Принадлежит:

The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C-Corganic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. 125-. (canceled)27. The silicone hydrogel contact lens of claim 26 , wherein in formula (1) Xis O.28. The silicone hydrogel contact lens of claim 27 , wherein in formula (1) ω1/υ1 is from about 0.040 to about 0.12.29. The silicone hydrogel contact lens of claim 28 , wherein in formula (2) q1 is zero or 1 claim 28 , n1 is an integer of 2 to 4 claim 28 , Ris hydrogen or methyl.31. The silicone hydrogel contact lens of claim 29 , wherein the crosslinked polymeric material comprises units of at least one hydrophilic vinylic monomer.32. The silicone hydrogel contact lens of claim 31 , wherein said at least one hydrophilic vinylic monomer is selected from the group consisting of N-vinylpyrrolidone claim 31 , N claim 31 ,N-dimethyl (meth)acrylamide claim 31 , (meth)acrylamide claim 31 , N-hydroxyethyl (meth)acrylamide claim 31 , N-hydroxypropyl (meth)acrylamide claim 31 , hydroxyethyl (meth)acrylate claim 31 , glycerol methacrylate (GMA) claim 31 , polyethylene glycol (meth)acrylate having a number average molecular weight of up to 1500 claim 31 , polyethylene glycol C-C-alkyl ether (meth)acrylate having a number average molecular weight of up to 1500 ...

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Номер записи: 24
14-01-2021 дата публикации

SILICONE HYDROGEL CONTACT LENSES

Номер: US20210009762A1
Автор: Breitkopf Richard Charles, Chang Frank, Ge Junhao, Jing Feng, Kumi Augustine Twum, Lang Weihong, Munoz Zach, Nelson Matthew D., Qian Xinming, Wu Daqing, Zhang Steve Yun, Zheng Ying
Принадлежит:

The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses. 147-. (canceled)49. The silicone hydrogel contact lens of claim 48 , wherein the silicone hydrogel bulk material comprises at least 9.0 mmole of the third repeating units per gram of all the first claim 48 , second and fourth repeating units in total.50. The silicone hydrogel contact lens of claim 48 , wherein the silicone hydrogel bulk material comprises at least 9.2 mmole of the third repeating units per gram of all the first claim 48 , second and fourth repeating units in total.51. The silicone hydrogel contact lens of claim 48 , wherein the silicone hydrogel bulk material comprises at least 9.6 mmole of the third repeating units per gram of all the first claim 48 , second and fourth repeating units in total.52. The silicone hydrogel contact lens of claim 48 , wherein the silicone hydrogel bulk material comprises at least 0.15 meqs of all the first claim 48 , second claim 48 , third and fourth H-donor moieties in total per gram of the third repeating units.53. The silicone hydrogel contact lens of claim 48 , wherein the silicone hydrogel bulk material comprises at least 0.20 meqs of all the first claim 48 , second claim 48 , third and fourth H-donor moieties in total per gram of the third repeating units.54. The silicone hydrogel contact lens of claim 48 , wherein the silicone hydrogel bulk material comprises at least 0.25 meqs of all the first claim 48 , second claim 48 , third and fourth H-donor moieties in total per gram of the third repeating units.55. The silicone hydrogel contact lens of claim 48 , wherein the silicone hydrogel contact lens has a water-break-up-time of at least 15 seconds without being subjected to any post- ...

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Номер записи: 25
14-01-2021 дата публикации

Method And Apparatus for Detection of Pitting Corrosion Under Iron Sulfide Deposition

Номер: US20210010366A1
Автор: CHANG Fakuen Frank, Chen Tao, WANG Qiwei
Принадлежит:

A method for monitoring pitting corrosion of a production tubing in a hydrocarbon well under downhole conditions during a production process using a coupon segment, the method comprising the steps of placing the coupon segment in the hydrocarbon well at a placement depth, the coupon segment is exposed to produced fluids and comprises an outer layer, an inner layer, and a hollow middle layer comprises a tracer fluid operable to leak into the produced fluids when pitting corrosion penetrates the outer layer, operating the production process in the hydrocarbon well such that produced fluids flow through the production tubing to a surface of the hydrocarbon well and wherein the produced fluids contact the coupon segment such that pitting corrosion occurs on the coupon segment; obtaining a sample of the produced fluids at the surface of the hydrocarbon well; and measuring an amount of the tracer fluid in the sample. 1. A method for monitoring pitting corrosion of a production tubing in a hydrocarbon well under downhole conditions during a production process using a coupon segment , the method comprising the steps of: an outer layer, wherein the outer layer comprises the same metallurgy as the production tubing, wherein the outer layer comprises a known thickness,', 'an inner layer, and', 'a hollow middle layer, wherein the hollow middle layer comprises a tracer fluid, wherein the tracer fluid is operable to leak from the hollow middle layer into the produced fluids when pitting corrosion penetrates the outer layer;, 'placing the coupon segment in the hydrocarbon well at a placement depth, wherein the coupon segment is exposed to produced fluids, wherein the coupon segment comprisesoperating the production process in the hydrocarbon well such that produced fluids flow through the production tubing to a surface of the hydrocarbon well, and wherein the produced fluids contact the coupon segment such that pitting corrosion occurs on the coupon segment;obtaining a sample of ...

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Номер записи: 26
14-01-2021 дата публикации

SILICONE HYDROGEL CONTACT LENSES

Номер: US20210011197A1
Автор: Breitkopf Richard Charles, Chang Frank, Ge Junhao, Jing Feng, Kumi Augustine Twum, Lang Weihong, Munoz Zach, Nelson Matthew D., Qian Xinming, Wu Daqing, Zhang Steve Yun, Zheng Ying
Принадлежит:

The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses. 147-. (canceled)49. The silicone hydrogel contact lens of claim 48 , wherein said one or more blending vinylic monomers are selected from the group consisting of methyl (meth)acrylate claim 48 , ethyl (meth)acrylate claim 48 , propyl (meth)acrylate claim 48 , isopropyl (meth)acrylate claim 48 , 2-ethylhexyl (meth)acrylate claim 48 , pentyl (meth)acrylate claim 48 , hexyl (meth)acrylate claim 48 , cyclopentylacrylate claim 48 , cyclohexylmethacrylate claim 48 , cyclohexylacrylate claim 48 , isobornyl (meth)acrylate claim 48 , styrene claim 48 , 4 claim 48 ,6-trimethylstyrene claim 48 , t-butyl styrene claim 48 , trifluoroethyl (meth)acrylate claim 48 , hexafluoro-isopropyl (meth)acrylate claim 48 , hexafluorobutyl (meth)acrylate claim 48 , and combinations thereof.50. The silicone hydrogel contact lens of claim 49 , wherein the linear chain-extended polysiloxane vinylic crosslinker comprises two terminal (meth)acryloyl groups and from 2 to 20 polysiloxane segments each pair of which are linked via an organic radical having at least two H-donor moieties selected from group consisting of urethane linkage of —OCONH— claim 49 , hydroxyl groups claim 49 , carboxyl groups claim 49 , amino groups of —NHR claim 49 , amino linkages of —NH— claim 49 , amide linkages of —CONH— claim 49 , and combinations thereof claim 49 , wherein the polysiloxane vinylic crosslinker.55. The silicone hydrogel contact lens of claim 50 , wherein the mono-(meth)acryloyl-terminated claim 50 , monoalkyl-terminated polysiloxane is mono-3-(meth)acryloxypropyl terminated mono-butyl terminated polydimethylsiloxane claim 50 , mono-3-(meth)acryloxypropyl terminated mono- ...

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Номер записи: 27
15-01-2015 дата публикации

Sub-carrier successive approximation millimeter wave radar for high-accuracy 3d imaging

Номер: US20150015432A1
Автор: Adrian J. Tang, Mau-Chung Frank Chang
Принадлежит: UNIVERSITY OF CALIFORNIA

A sub-carrier successive approximation (SCSA) radar having a sufficiently high accuracy to capture 3D images of concealed objects. The invention is phase-based, and directly measures round trip time by estimating the phase delay of the carrier. One of its advantages is that the carrier does not need to sweep across a wide frequency range, thereby relaxing RF front-end bandwidth and linearity requirements. SCSA radar accuracy is limited only by the extent of system noise, allowing very high accuracy to be achieved with a sufficient integration period. The SCSA radar can be readily implemented in CMOS, as well as other device technologies, and fabricated within one or more small integrated circuits.

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Номер записи: 28
17-01-2019 дата публикации

UNMANNED AERIAL VEHICLE AND METHOD USING THE SAME

Номер: US20190016461A1
Автор: Chang Mau-Chung Frank, CHEN Chiun-Hsun
Принадлежит:

An unmanned aerial vehicle (UAV) includes a body, a plurality of rotated propulsion systems, and at least one air bag. The rotated propulsion systems are connected to the body and each includes a blade and an actuator configured to actuate the blade. The air bag is disposed on the body. 1. An unmanned aerial vehicle (UAV) , comprising:a body;a plurality of rotated propulsion systems connected to the body and each comprising a blade and an actuator configured to actuate the blade; andat least one air bag disposed on the body.2. The UAV of claim 1 , further comprising a gas cylinder connected to the air bag.3. The UAV of claim 1 , wherein the body comprises a case having a door claim 1 , and the air bag is moved out of the case through the door.4. The UAV of claim 3 , further comprising a trigger controller connected to the door claim 3 , wherein the trigger controller is configured to open the door.5. The UAV of claim 3 , further comprising:an air bag recycling motor disposed in the case; anda towing rope connecting the air bag to the air bag recycling motor.6. The UAV of claim 1 , further comprising:an inflation device connected to the air bag; anda remote control device electrically connected to the inflation device.7. The UAV of claim 1 , wherein each of the rotated propulsion systems further comprises:a turning mechanism connected to the actuator, wherein the turning mechanism is configured to move the blade.8. The UAV of claim 1 , wherein the air bag is plural.9. The UAV of claim 8 , wherein the body is in a rectangular shape claim 8 , and the air bags are disposed at corners of the rectangular body claim 8 , respectively.10. The UAV of claim 9 , wherein each of the rotated propulsion systems are disposed between the air bags at the corners of the rectangular body.11. The UAV of claim 1 , where a number of the air bag is equal to a number of the rotated propulsion systems.12. The UAV of claim 1 , wherein an upper half portion of the air bag is above the rotated ...

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Номер записи: 29
21-01-2016 дата публикации

Stabilized peptide fragments from redoxin proteins as cancer biomarkers

Номер: US20160018403A1
Автор: Frank N. Chang, George P. Tuszynski
Принадлежит: Temple University of Commonwealth System of Higher Education

An embodiment of the invention relates to the use of stabilized cancer peptide fragments derived from “redoxin proteins” selected from the group consisting of thioredoxin; peroxiredoxin-1, 2 and 3; glutaredoxin-3; glutathione peroxidase-4; and nucleoredoxins for the diagnosis of cancers, particularly pancreatic cancer. A method for the detection of cancer, severity of cancer, and/or effectiveness of a therapeutic regimen comprises detecting and/or measuring the amount of redoxin peptide fragments present in the biological sample of a subject.

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Номер записи: 30
17-01-2019 дата публикации

STABILIZED PEPTIDE FRAGMENTS FROM PROTOCADHERIN FAT1 AS CANCER BIOMARKERS

Номер: US20190016821A1
Автор: Chang Frank N.
Принадлежит: Temple University of the Commonwealth System of Higher Education

An embodiment of the invention relates to the use of stabilized cancer peptide fragments derived from Protocadherin FAT1 for the diagnosis of cancers, particularly pancreatic cancer. A method for the detection of cancer, severity of cancer, and/or effectiveness of a therapeutic regimen includes detecting and/or measuring the amount of Protocadherin FAT1 peptide fragments present in the biological sample of a subject. 1. A biomolecule that is selective for a Protocadherin FAT1 peptide fragment having an amino acid sequence selected from the group consisting of SEQ ID NOS: 1-11.2. The biomolecule of claim 1 , wherein the biomolecule is an antibody or an antibody fragment.3. The biomolecule of claim 1 , wherein the biomolecule is a monoclonal antibody or a polyclonal antibody.4. The biomolecule of claim 1 , wherein the biomolecule is selected from the group consisting of a recombinant antibody claim 1 , a recombinant monoclonal antibody claim 1 , a polyclonal antibody claim 1 , a humanized antibody and an antibody fragment.5. The biomolecule of claim 1 , wherein the biomolecule is useful for diagnosing cancers that utilize Protocadherin FAT1 protein.6. The biomolecule of claim 1 , wherein the biomolecule is useful for determining whether a subject is predisposed to cancers that utilize Protocadherin FAT1 protein.7. The biomolecule of claim 1 , wherein the biomolecule is useful for diagnosing cancer selected from the group consisting of breast cancer claim 1 , ovarian cancer claim 1 , colon cancer claim 1 , endometrial carcinoma claim 1 , esophagus squamous cell carcinoma claim 1 , glioma claim 1 , hepatocellular carcinoma claim 1 , infiltrating ductal breast carcinoma claim 1 , larynx cancer claim 1 , lung squamous cell carcinoma claim 1 , melanoma claim 1 , mucinous cystadenocarcinoma of ovary claim 1 , pancreatic cancer claim 1 , prostate cancer claim 1 , renal cell carcinoma claim 1 , small bowel malignant stromal tumor claim 1 , and stomach adenocarcinoma.8. The ...

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Номер записи: 31
24-01-2019 дата публикации

PHOSPHORYLCHOLINE-CONTAINING POLY(METH)ACRYLAMIDE-BASED COPOLYMERS

Номер: US20190023891A1
Автор: Chang Frank, Chiang Chung-Yuan, Holland Troy Vernon, Jing Feng, Pruitt John Dallas
Принадлежит:

The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymer comprising dangling (i.e., pendant) phosphorylcholine groups and dangling (i.e., pendant) reactive groups or chains each of which comprises one carboxyl group, one thiol group, or one primary or secondary amino group. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses. 2. The hydrophilic polymer of claim 1 , wherein the poly(meth)acrylamide-based copolymer comprises at least about 50% by mole of the first repeating units relative to all repeating units of the poly(meth)acrylamide-based copolymer.3. The hydrophilic polymer of claim 2 , wherein the poly(meth)acrylamide-based copolymer comprises from about 0.01% to about 40% by mole by mole of the second repeating units relative to all repeating units of the poly(meth)acrylamide-based copolymer.5. The hydrophilic polymer of claim 4 , wherein claim 4 , in formula (3) to (10) claim 4 , Xis —NR— in which Ris hydrogen or a C-Calkyl group.6. The hydrophilic polymer of claim 5 , wherein the poly(meth)acrylamide-based copolymer further comprises third repeating units which are acrylic repeating units of one or more acrylic monomers which are free of any carboxyl group or any primary or secondary amino group.7. The hydrophilic polymer of claim 5 , wherein the third repeating units are selected from the group consisting of 2-(meth)acryloyloxy)ethyl-2′-(trimethylammonio)ethylphosphate claim 5 , 3-((meth)acryloyloxy)propyl-2′-(trimethylammonio)ethylphosphate claim 5 , 4-((meth)acryloyloxy)butyl-2′-(trimethylammonio)ethyl phosphate claim 5 , 5-((meth)acryloyloxy) pentyl-2′-(trimethylammonio)ethyl phosphate claim 5 , 6 ...

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Номер записи: 32
24-01-2019 дата публикации

POLY(METH)ACRYLAMIDE-BASED COPOLYMERS WITH CARBOXYL-TERMINATED PENDANT CHAINS

Номер: US20190023935A1
Автор: Chang Frank, Chiang Chung-Yuan, Holland Troy Vernon, Jing Feng, Pruitt John Dallas
Принадлежит:

The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses. 2. The hydrophilic polymer of claim 1 , wherein the poly(meth)acrylamide-based copolymer comprises at least about 50% by mole of the first repeating units and from about 0.01% to about 40% by mole by mole of the second repeating units claim 1 , relative to all repeating units of the poly(meth)acrylamide-based copolymer.3. The hydrophilic polymer of claim 2 , wherein the second repeating units comprises acrylic repeating units each of which is a repeating unit of formula (1).4. The hydrophilic polymer of claim 2 , wherein the second repeating units comprises acrylic repeating units each of which is a repeating unit of formula (2).5. The hydrophilic polymer of claim 2 , wherein the second repeating units comprises acrylic repeating units each of which is a repeating unit of formula (3).6. The hydrophilic polymer of claim 2 , wherein the second repeating units comprises acrylic repeating units each of which is a repeating unit of formula (4).7. The hydrophilic polymer of claim 2 , wherein the second repeating units comprises acrylic repeating units each of which is a repeating unit of formula (5).8. The hydrophilic polymer of claim 7 , wherein claim 7 , in formula (1) to (5) claim 7 , Xis —NR— in which Ris hydrogen or a C-Calkyl group.9. The ...

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Номер записи: 33
23-01-2020 дата публикации

METHOD OF SUBTERRANEAN FRACTURING

Номер: US20200024936A1
Автор: Bouldin Brett, CHANG Fakuen Frank, Nugraha Ikhsan
Принадлежит: Saudi Arabian Oil Company

A system and method of wellbore operations that forms notches into a subterranean formation that circumscribes a wellbore prior to fracturing the formation. The notches extend past the hoop stress regime that surrounds the wellbore so that fractures formed by fracturing are oriented in a designated plane. In one example, a fluid jet is used to form the notches, and which is discharged from a nozzle that rotates about a downhole tool. The nozzle is set in a sleeve that is rotatable about the downhole tool, and pressurized fluid is delivered to a plenum disposed on an inner surface of the sleeve. The nozzle is oriented oblique to a radius of the sleeve, so that the fluid being discharged from the nozzle generates a force that rotates the sleeve. 1. A system for operations in a wellbore comprising:a source of pressurized fluid;an annular mandrel having an axial bore in selective communication with pressurized fluid from the source of pressurized fluid;a nozzle provided with the mandrel that is in communication with the pressurized fluid, and having a discharge that where pressurized fluid exits the nozzle in the form of a fluid jet that intersects a wall of the wellbore along a path that circumscribes the mandrel; anda fracturing system coupled with the mandrel and that is selectively positioned in a closed configuration where the pressurized fluid is retained within the fracturing system and an open configuration where the pressurized fluid is released from the fracturing system.2. The system of claim 1 , further comprising a nozzle sleeve circumscribing the mandrel and that is selectively rotatable about the mandrel claim 1 , and where the nozzle is radially oriented in the nozzle sleeve claim 1 , the nozzle comprising claim 1 ,a passage oriented oblique to a radius of the sleeve, andan inlet to the passage that is in selective communication with the axial bore in the mandrel, so that when pressurized fluid is in the axial bore, the pressurized fluid flows through ...

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Номер записи: 34
04-02-2016 дата публикации

Water-processable silicone-containing prepolymers and uses thereof

Номер: US20160033683A1
Автор: Arturo Norberto Medina, Daqing Wu, Dawn Alison Smith, Frank Chang, Jinyu Huang, Robert Scott, Selma Kuyu, Venkat Shankar
Принадлежит: NOVARTIS AG

The invention provide a class of water-processable polymerizable prepolymers which comprises (1) siloxane-containing monomeric units derived at least one siloxane containing monomer having one hydrophilic group or chain and/or polysiloxane-containing crosslinking units derived from at least one hydrophilized polysiloxane or chain-extended polysiloxane crosslinker; (2) hydrophilic monomeric units derived from one or more hydrophilic vinylic monomers; and (3) from about 0.05% to about 5% by weight of polymerizable units each having a pendant or terminal, ethylenically-unsaturated group and free of any polysiloxane segment. The prepolymer comprises from about 20% to about 50% by weight of silicone relative to the total weight of the prepolymer and has a high water solubility or dispersibility of at least about 5% by weight in water and suitable for making silicone hydrogel contact lenses.

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Номер записи: 35
03-03-2016 дата публикации

POLY(OXAZOLINE-CO-ETHYLENEIMINE)-EPICHLOROHYDRIN COPOLYMERS AND USES THEREOF

Номер: US20160061995A1
Автор: Chang Frank, Holland Troy Vernon
Принадлежит:

The invention is related to poly(2-oxazoline-co-ethyleneimine)-epichlorohydrin copolymers and chemically-modified derivatives thereof as well as their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses. 5. The poly(2-oxazoline-co-ethyleneimine)-epichlorohydrin copolymer of claim 1 , wherein the poly(2-oxazoline-co-ethyleneimine)-epichlorohydrin copolymer comprises: (1) from about 10% to about 85% by mole of N-acyl-iminoethylene monomeric units; (2) from about 2.5% to about 75% by mole of azetidinium monomeric units; (3) from 0% to about 60% by mole of ethyleneimine monomeric units; and (4) from 0 to about 5% by mole of crosslink units.6. The poly(2-oxazoline-co-ethyleneimine)-epichlorohydrin copolymer of claim 5 , having a weight average molecular weight Mw of at least about 500 Daltons.8. The water-soluble and thermally crosslinkable hydrophilic polymeric material of claim 7 , wherein the hydrophilicity-enhancing polymeric agent is a hydrophilic polymers having one or more amino claim 7 , carboxyl and/or thiol groups claim 7 , wherein the content of the amino claim 7 , carboxyl and/or thiol groups in the hydrophilic polymer as the hydrophilicity-enhancing agent is less than about 40% by weight based on the total weight of the hydrophilic polymer.9. The water-soluble and thermally crosslinkable hydrophilic polymeric material of claim 8 , wherein the hydrophilic polymer as the hydrophilicity-enhancing agent is: PEG-NH; PEG-SH; PEG-COOH; HN-PEG-NH; HOOC-PEG-COOH; HS-PEG-SH; HN-PEG-COOH; HOOC-PEG-SH; HN-PEG-SH; multi-arm PEG with one or more amino claim 8 , carboxyl or thiol groups; PEG dendrimers with one or more amino claim 8 , carboxyl or thiol groups; a diamino- claim 8 , dicarboxyl- claim 8 , monoamino- or monocarboxyl-terminated homo- or co-polymer of a non-reactive hydrophilic vinylic monomer; a copolymer which is a polymerization product of a composition comprising (1) about 60% by weight or less claim 8 , preferably from ...

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Номер записи: 36
02-03-2017 дата публикации

BOOTSTRAPPED AND CORRELATED DOUBLE SAMPLING (BCDS) NON-CONTACT TOUCH SENSOR FOR MOBILE DEVICES

Номер: US20170060342A1
Автор: Chang Mau-Chung Frank, Tang Adrian J.
Принадлежит: The Regents of the University of California

Non-contact position and motion sensing is improved for oscillator frequency based sensors in response to adding a two phase calibration along with bootstrapping circuit. Calibration is performed across the multiple sensor channels, so that: (1) maximum sensor channel loading is determined, and (2) the amount of capacitive load required for each other channel to match this same maximum load is stored for application to that channel during non-contact sensing. Capacitive coupling between channels is nullified by a bootstrapping process, in which time-domain voltage on the active channel is replicated on the non-active channels during non-contact sensing, thus creating equal potentials across inter-channel couplings that effectively eliminate inter-channel capacitive loading. 1. A non-contact position and motion sensing apparatus , comprising:multiple sensor channels;an oscillator circuit configured for being separately connected to each channel of said multiple sensor channels while performing non-contact sensing;a counter circuit configured for counting oscillator periods over an integration time window and outputting a binary count value as an estimation of the frequency output of said oscillator;a count storage and comparison circuit, coupled to said counter circuit, and configured for performing a calibration in which maximum load placed on said oscillator from a sensor channel is determined from said multiple sensor channels, and a capacitive loading is determined for each other channel to equalize loading during non-contact sensing operation; anda bootstrap circuit coupled to each of said multiple sensor channels and configured for sensing time-domain voltage of an active channel in said multiple sensor channels and replicating it on remaining non-active channels during non-contact sensing to nullify capacitive coupling with the active channel in response to enforcing equal potentials across inter-channel coupling;wherein during operation for non-contact ...

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Номер записи: 37
03-03-2016 дата публикации

HOLLOW PLASTIC WAVEGUIDE FOR DATA CENTER COMMUNICATIONS

Номер: US20160064795A1
Автор: Chang Mau-Chung Frank, Kim Yanghyo, Nan Lan
Принадлежит: The Regents of the University of California

A wave cable transceiver system is disclosed incorporating an air-core or noble gas filled hollow plastic waveguide. The system may include a transmitter receiver, in-antennas and a tubular plastic waveguide with the inner air-core. The hollow plastic waveguide is a low loss and low dispersion guiding channel for the electromagnetic radiation. 1. A waveguide for guiding electromagnetic radiation , comprising:a hollow polymeric cable for guiding electromagnetic radiation;the cable comprising an inner channel defining an air-core or noble gas filled chamber;wherein the inner channel is surrounded by a dielectric polymeric layer.2. A waveguide as recited in claim 1 , wherein the cable comprises a tubular elongate member having an outer radius and inner radius.3. A waveguide as recited in claim 1 , wherein the cable comprises plastic.4. A waveguide as recited in claim 1 , wherein the polymeric layer is coated with an outer material having a higher dielectric constant than the polymeric layer.5. A waveguide as recited in claim 2 , wherein a ratio between the inner radius and outer radius is configured to minimize link loss of the electromagnetic radiation.6. A waveguide as recited in claim 5 , wherein the cable is configured as a link for inter-server communications.7. A waveguide as recited in claim 6 , wherein the cable is configured as mid-range link having a ratio r/rranging between 0.4 and 0.8.8. A waveguide as recited in claim 7 , wherein the ratio r/rranges between 0.5 and 0.7.9. A waveguide as recited in :wherein the cable is a component in an inter-server communications interconnect; andwherein the cable comprises first and second ends, each of the first and second ends coupled to an RF transmitter, or an RF receiver, or an RF transceiver.10. An interconnect device for inter-server communications claim 6 , comprising:a hollow polymeric waveguide;the waveguide comprising an inner channel defining an air-core or noble gas filled chamber;the waveguide having first ...

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Номер записи: 38
28-02-2019 дата публикации

CAST-MOLDING PROCESS FOR PRODUCING CONTACT LENSES

Номер: US20190061293A1
Автор: Chang Frank, DeSousa Ryan, Holland Troy Vernon
Принадлежит:

Described herein is a cast-molding process for producing contact lenses in a relatively short curing time. The short curing time has been achieved by adding a chain transfer agent into a lens-forming composition. 1. A process for producing contact lenses , comprising the steps of:obtaining a lens-forming composition comprising at least one lens-forming material, at least one photoinitiator, and at least one thiol-containing compound or polymer in an amount for reducing the curing time of the lens-forming composition by at least 20%, compared to a control composition;introducing the lens-forming composition into a mold, wherein the mold has a first mold half with a first molding surface defining the anterior surface of a contact lens and a second mold half with a second molding surface defining the posterior surface of the contact lens, wherein said first and second mold halves are configured to receive each other such that a cavity for receiving the lens-forming composition is formed between said first and second molding surfaces; andirradiating, with a UV or visible light, the lens-forming composition in the mold for a time period of about 15 seconds or less, so as to crosslink and/or polymerize said at least one lens-forming material to form the contact lens.2. The process of claim 1 , wherein the photoinitiator is a visible-light photoinitiator which can initiates free radical crosslinking and/or polymerizing reaction upon irradiation with a visible light having a wavelength greater than 380 nm and less than 500 nm and the step of irradiating is performed by using the visible light having a wavelength greater than 380 nm and less than 500 nm.3. The process of claim 2 , wherein the lens-forming material comprises at least one vinylic macromer or at least one prepolymer.4. The process of claim 2 , wherein the lens-forming material comprises a water-soluble prepolymer.5. The process of claim 4 , wherein the water-soluble prepolymer is free of silicone.10. The ...

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Номер записи: 39
28-02-2019 дата публикации

AMPHIPHILIC BRANCHED POLYDIORGANOSILOXANE MACROMERS

Номер: US20190062485A1
Автор: Chang Frank, Holland Troy Vernon, HUANG JINYU
Принадлежит:

The invention provides a class of amphiphilic branched macromers and the uses thereof. An amphiphilic branched polydiorganosiloxane macromer of the invention is produced from an α,ω-dimethacryloyl-terminated polydiorganosiloxane vinylic crosslinker comprising one or more ATRP-containing siloxane units having one substituent having an ATRP initiator by ATRP polymerization of one or more hydrophilic vinylic monomers. It comprises at least two polydiorganosiloxane polymer chains each having at most two terminal methacryloxy groups, dangling hydrophilic polymer chains each having a polymerizable or non-polymerizable terminal group, and one or more hydrophilic polymer chains as linkages between two polydiorganosiloxane chains. The present invention is also related to a silicone hydrogel contact lens, which comprises units derived from a polydiorganosiloxane-containing amphiphilic branched macromer of the invention. 14-. (canceled)5. A silicone hydrogel contact lens , comprising a crosslinked polymeric material which comprises units of an amphiphilic branched polydiorganosiloxane macromer , wherein the amphiphilic branched polydiorganosiloxane macromer comprises:(1) at least first polydiorganosiloxane polymer chain having two terminal methacryloyl groups; and(2) at least one first hydrophilic chain;(3) at least one second hydrophilic polymer chain; and(4) at least one second polydiorganosiloxane polymer chain at least one end of which is covalently connected to the second hydrophilic polymer chain,wherein the first and second polydiorganosiloxane chains are derived from an α,ω-dimethacryloyl-terminated polydiorganosiloxane vinylic crosslinker comprising one or more ATRP-containing siloxane units having one substituent having an ATRP initiator,wherein the first hydrophilic chain is anchored covalently onto one single ATRP-containing siloxane unit of the first or second polydiorganosiloxane chain at one of the two ends of the first hydrophilic polymer chain and has one ...

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Номер записи: 40
08-03-2018 дата публикации

COMPOSITIONS OF AND METHODS FOR USING HYDRAULIC FRACTURING FLUID FOR PETROLEUM PRODUCTION

Номер: US20180066178A1
Автор: Berger Paul D., CHANG Fakuen Frank, Lee Christie H.
Принадлежит:

A hydraulic fracturing fluid for use in oilfield applications, where hydraulic fracturing fluid includes a spherical bead-forming liquid composition, the spherical bead-forming liquid composition comprising a micellar forming surfactant, a bead-forming compound, a non-solids bearing liquid solvent, a pH control agent, and a curing agent. 1. A hydraulic fracturing fluid formulation for use in oilfield applications , the hydraulic fracturing fluid formulation comprising:a primary liquid precursor; anda secondary liquid precursor,where a mixture of the primary liquid precursor and the secondary liquid precursor forms solid, individual, spherical beads in situ in a hydrocarbon-bearing reservoir upon mixing, andwhere the solid, individual, spherical beads are formed from non-solids bearing liquids and are of sufficient mechanical strength to act as a proppant in situ and hold fractures open against an overburden pressure.2. The formulation of claim 1 , where the primary liquid precursor comprises a micellar forming surfactant.3. The formulation of claim 1 , where the primary liquid precursor comprises a bead-forming compound.4. The formulation of claim 1 , where the primary liquid precursor comprises a non-solids bearing liquid solvent.5. The formulation of claim 1 , where the primary liquid precursor comprises an anti-foaming agent.6. The formulation of claim 1 , where the primary liquid precursor comprises a pH control agent.7. The formulation of claim 1 , where the primary liquid precursor comprises a retarder.8. The formulation of claim 1 , where the secondary liquid precursor comprises a curing agent.9. The formulation of claim 1 , where the secondary liquid precursor comprises a co-curing agent.10. The formulation of claim 1 , where the secondary liquid precursor comprises a retarder.11. The formulation of claim 2 , where the micellar forming surfactant is selected from the group consisting of anionic surfactants claim 2 , cationic surfactants claim 2 , nonionic ...

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Номер записи: 41
09-03-2017 дата публикации

SOFT SILICONE MEDICAL DEVICES WITH DURABLE LUBRICIOUS COATINGS THEREON

Номер: US20170068018A1
Автор: Chang Frank, Matsuzawa Yasuo, Qian Xinming, Shankar Venkat
Принадлежит:

The invention is related to a medical device comprising a core material made of a crosslinked silicone material and a hydrogel coating which is thermodynamically stable. The invention is also related to a method for producing such a medical device, especially a soft contact lens. 2. The medical device of claim 1 , wherein the medical device is an ophthalmic device.3. The medical device of claim 2 , wherein the ophthalmic device is an intraocular lens claim 2 , a stent claim 2 , a device under eyelids claim 2 , a corneal onlay claim 2 , a glaucoma shunt claim 2 , or an implant.4. The medical device of claim 1 , wherein the silicone substrate is a silicone contact lens claim 1 , wherein the medical device is a soft contact lens having an oxygen permeability (Dk) of at least about 125 barrers in a fully-hydrated state.5. The medical device of claim 4 , wherein the soft contact lens has at least one property selected from the group consisting of: an elastic modulus of about 2.0 MPa or less; a surface wettability characterized by having an averaged water contact angle of about 80 degrees or less; and combinations thereof6. The medical device of claim 1 , wherein the medical device comprises the silicone substrate claim 1 , a base coating directly on the surface of the silicone substrate claim 1 , and a hydrogel layer covalently attached onto the base coating.7. The medical device of claim 6 , wherein the base coating comprises a plasma layer which is directly on the surface of the silicone substrate.8. The medical device of claim 6 , wherein the base coating comprises a prime plasma layer and a reactive polymer layer on top of the prime plasma layer claim 6 , wherein the prime plasma layer is directly on the surface of the silicone substrate and has a thickness of less than about 40 nm claim 6 , wherein the hydrogel coating comprises the hydrogel layer crosslinked with the reactive polymer layer.9. The medical device of claim 8 , wherein the hydrogel coating has a water ...

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Номер записи: 42
09-03-2017 дата публикации

METHOD FOR PRODUCING CONTACT LENSES WITH DURABLE LUBRICIOUS COATINGS THEREON

Номер: US20170068019A1
Автор: Chang Frank, Matsuzawa Yasuo, Qian Xinming, Shankar Venkat
Принадлежит:

The invention is related to a method for producing silicone hydrogel contact lenses with a stable lubricious hydrogel coating thereon. A method of the invention comprises forming a plasma-reactive hydrophilic polymer hybrid base coating having reactive functional groups on a silicone hydrogel contact lens and heating the silicone hydrogel contact lens with the hybrid base coating in an aqueous solution of a water-soluble and thermally crosslinkable hydrophilic polymeric material to form a stable lubricious hydrogel coating thereon. 1. A method for producing soft contact lenses , comprising the steps of:(1) obtaining a preformed silicone hydrogel contact lens in a dry state; [{'sub': 2', '2', '2', '1', '6', '2', '2', '2, '(a) plasma-treating the surface of the preformed silicone hydrogel contact lens in the dry state with a plasma to obtain a silicone hydrogel contact lens with the prime plasma layer thereon, wherein the plasma is generated in a plasma gas composed of air, N, O, CO, or a mixture of a C-Chydrocarbon and a secondary gas selected from the group consisting of air, N, O, CO, and combinations thereof, wherein the prime plasma layer has a thickness of from about 0.5 nm to about 40 nm, and'}, '(b) contacting the silicone hydrogel contact lens with the prime plasma layer thereon with a first aqueous solution including a reactive hydrophilic polymer having multiple reactive functional groups selected from the group consisting of carboxyl groups, primary amino groups, secondary amino groups, and combinations thereof to form the base coating which include the reactive polymer layer of the reactive hydrophilic polymer on top of the prime plasma layer; and, '(2) subjecting the preformed silicone hydrogel contact lens in the dry state to a surface treatment to obtain a silicone hydrogel contact lens with a base coating thereon, wherein the base coating comprises a prime plasma layer, a reactive polymer layer on top of the prime plasma layer, and reactive functional ...

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Номер записи: 43
10-03-2016 дата публикации

LOW JITTER TUNABLE VOLTAGE CONTROL OSCILLATOR WITH SELF CALIBRATION CIRCUITS TO REDUCE CHIP FABRICATION PROCESS VARIATION

Номер: US20160072482A1
Автор: Chang Mau-Chung Frank, Lee Sheau Jiung, Li Yilei, Virbila Gabriel
Принадлежит: The Regents of the University of California

A voltage controlled oscillator (VCO) which can be configured with a smaller tuning range than is ordinarily required is presented. Ordinarily, the tuning range is selected much broader than the application warrants so that sufficient range is still provided despite VCO process variations. The inventive VCO is able to substantially eliminate the effects of process variation by utilizing a calibration circuit and process, so that variation in VCO device operation is minimized despite substantial process variation. Accordingly, the inventive VCO device is subject to reduced levels of jitter as its range need not be utilized for overcoming process variation arising during device fabrication. 1. A voltage controlled oscillator (VCO) apparatus , comprising:a ring oscillator comprising multiple digital stages of current mode logic (CML) inverters to generate an oscillation frequency;a resistor emulator that emulates an external resistor device which is constant despite fabrication process variation;a self calibration controller circuit that in its calibration mode adjusts resistance provided by said resistor emulator to create a RC delay in said current mode logic (CML) inverters according to target running frequency of said VCO apparatus;an amplifier configured for amplifying an input control voltage to the VCO and outputting a first control voltage to said ring oscillator; andan adaptive bias current generator circuit configured for adjusting bias current by providing a second control voltage to said ring oscillator, said adaptive bias current generator performs automatic feedback control based on said resistor emulator and input control voltage of VCO to control both frequency and output swing of said ring oscillator;whereby said VCO apparatus generates a frequency output proportional to said input control voltage with reduced impact from fabrication process variation.2. The apparatus recited in claim 1 , wherein frequency of the VCO apparatus is inversely proportional ...

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Номер записи: 44
24-03-2022 дата публикации

COMPOSITE POROUS INTERBODIES AND METHODS OF MANUFACTURE

Номер: US20220087819A1
Автор: Chang Frank, Leong Steven, Robinson Scott
Принадлежит:

A method of forming a composite titanium body for use in forming spinal implant interbodies includes selecting a metal alloy body, carving out a top portion and a bottom portion from the metal alloy body, and bonding a porous material to the carved-out top and bottom portions. Multiple pieces may be cut from the composite titanium body, each having a front face formed of the metal alloy, top and bottom portions formed of the porous material, and with a medial portion of the metal alloy extending from the front face to the back. Methods and devices for spinal interbodies having locking mechanisms to prevent bone screw back-out are also described. 1. A method of manufacturing a composite interbody , the method comprising:selecting a solid titanium body having a top side and a bottom side;carving out a portion of the top side of the solid titanium body to form a top portion void;carving out a portion of the bottom side of the solid titanium body to form a bottom portion void;diffusion bonding porous titanium to the top portion void;diffusion bonding porous titanium to the bottom portion void, the steps of diffusion bonding porous titanium to the top portion void and bottom portion void forming a composite titanium block; andcutting out a composite interbody from the composite titanium block.2. A composite interbody system comprising:a body having an anterior face and an opposing posterior face, a top portion and a bottom portion, with a medial portion extending through the body from the anterior face to the opposing posterior face; andthe anterior face formed of titanium alloy, the top portion and bottom portion formed of porous titanium, and the medial portion formed of titanium alloy.3. The composite interbody system of claim 2 , wherein the anterior face and medial portion are formed of a single piece of titanium alloy.4. The composite interbody system of claim 3 , wherein the porous titanium comprises sheets of porous titanium diffusion bonded together to form the ...

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Номер записи: 45
02-04-2015 дата публикации

SILICONE HYDROGEL LENSES WITH RELATIVELY-LONG THERMAL STABILITY

Номер: US20150092155A1
Автор: Chang Frank, DeSousa Ryan, HUANG JINYU
Принадлежит:

The invention provides silicone hydrogel ophthalmic lenses (in particular contact lenses) having relatively-long thermal stability and methods for making such ophthalmic lenses. 2. The soft contact lens of claim 1 , wherein the first repeating units are derived from a (meth)acrylamide-type monomer which is N claim 1 ,N-dimethyl (meth)acrylamide claim 1 , N-(hydroxymethyl)acrylamide claim 1 , N-hydroxyethyl acrylamide claim 1 , N-hydroxypropyl acrylamide claim 1 , N-[Tris(hydroxymethyl)methyl] acrylamide claim 1 , acrylamide claim 1 , methacrylamide claim 1 , N-(2-aminoethyl)(meth)acrylamide claim 1 , N-(3-aminopropyl)(meth)acrylamide claim 1 , or a mixture thereof.3. The soft contact lens of claim 2 , having: an oxygen permeability (Dk) of at least about 40 barrers; a water content of from about 20% to about 75% by weight when fully hydrated; and an elastic modulus of from about 0.2 MPa to about 1.8 MPa.4. The soft contact lens of claim 3 , wherein the second repeating units are derived from a siloxane vinylic monomer of formula (I).5. The soft contact lens of claim 4 , wherein the second repeating units are derived from a siloxane vinylic monomer of formula (I) in which: R′ is hydrogen; r1 and r2 are zero; R″ is methyl; Ris a substituted or unsubstituted C-Calkylene divalent group; Rand Rindependent of each other are methyl; or combinations thereof.7. The soft contact lens of claim 3 , wherein the second repeating units are derived from a siloxane vinylic monomer of formula (II) (preferably in formula (II) claim 3 , R′ is hydrogen; r1 and r2 are zero; Ra substituted or unsubstituted C-Calkylene divalent radical; R″ is C-Calkyl; Ris C-Calkyl).8. The soft contact lens of claim 7 , wherein R′ is hydrogen claim 7 , r1 and r2 are zero claim 7 , Ra substituted or unsubstituted C-Calkylene divalent radical claim 7 , R″ is C-Calkyl claim 7 , and Ris C-Calkyl claim 7 , in formula (II).10. The soft contact lens of claim 9 , wherein the third repeating units are derived from ...

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Номер записи: 46
31-03-2016 дата публикации

POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS

Номер: US20160090432A1
Автор: Chang Frank, HUANG JINYU, Shankar Venkat
Принадлежит:

The invention provides an actinically-polymerizable amphiphilic polysiloxane which comprises a polysiloxane polymer chain comprising a polylsiloxane segments comprising at least one siloxane unit having a low molecular weight hydrophilic polymer chain connected with a silicone atom of the siloxane unit, and (meth)acrylamido groups each covalently bonded to one of the ends of the polysiloxane polymer chain and/or to the end of one of low molecular weight hydrophilic polymer chains each connected with one silicone atom. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises repeating units derived from an actinically-polymerizable amphiphilic polysiloxane of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an actinically-polymerizable amphiphilic polysiloxane of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention. 5. The actinically-polymerizable amphiphilic polysiloxane of claim 1 , wherein R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Rare methyl.6. The actinically-polymerizable amphiphilic polysiloxane of claim 1 , wherein ν2 is an integer of an integer of from 3 to 350 while ω2 is an integer of from 1 to 10.7. The actinically-polymerizable amphiphilic polysiloxane of claim 1 , wherein hPC is a hydrophilic polymer segment composed of hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer selected from the group consisting of N-vinylpyrrolidone claim 1 , N claim 1 ,N-dimethyl (meth)acrylamide claim 1 , (meth)acrylamide claim 1 , N-vinyl formamide claim 1 , N-vinyl acetamide claim 1 , N-vinyl isopropylamide claim 1 , N-vinyl-N-methyl acetamide claim 1 , N-methyl-3-methylene-2-pyrrolidone claim 1 , 1-ethyl-3-methylene-2- ...

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Номер записи: 47
02-04-2015 дата публикации

METHOD FOR MAKING UV-ABSORBING OPHTHALMIC LENSES

Номер: US20150094393A1
Автор: Chang Frank, Haken Uwe, Holland Troy Vernon, III Joseph I., Weinschenk
Принадлежит:

Described herein is a method for producing UV-absorbing silicone hydrogel contact lenses, which is free or substantially free of internal stress and also is capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 381 nm to 440 nm, according to a photocuring technology, preferably according to the Lightstream Technology™. This invention also provides UV-absorbing contact lenses made according to a method of the invention. 1. A method for producing UV-absorbing silicone hydrogel contact lenses which have an UVB transmittance of about 10% or less between 280 and 315 nanometers , an UVA transmittance of about 30% or less between 316 and 380 nanometers , and optionally an average violet transmittance of about 70% or less between 381 nm and 440 nm , the method comprising the steps of:(1) providing a mold for making a soft contact lens, wherein the mold has a first mold half with a first molding surface defining the anterior surface of a contact lens and a second mold half with a second molding surface defining the posterior surface of the contact lens, wherein said first and second mold halves are configured to receive each other such that a cavity is formed between said first and second molding surfaces;(2) introducing a pre-polymerization mixture of lens-forming materials into the cavity, wherein the pre-polymerization mixture comprises at least one hydrophilic vinylic monomer, at least one siloxane-containing vinylic monomer, at least one polysiloxane crosslinker with two or more ethylenically-unsaturated groups, at least one UV-absorbing vinylic monomer that absorbs ultraviolet light and optionally high-energy violet light from 381 nm to 440 nm, at least one visibility-tinting agent, and from about 0.05% to about 1.5% by weight of at least one germanium-based Norrish Type I photoinitiator capable of initiating a free-radical polymerization under irradiation with a light source including a light in the ...

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Номер записи: 48
19-06-2014 дата публикации

AMPHIPHILIC SILOXANE-CONTAINING (METH)ACRYLAMIDES AND USES THEREOF

Номер: US20140171539A1
Автор: Chang Frank, Zhou Jian S.
Принадлежит: NOVARTIS AG

The invention provides an amphiphilic siloxane-containing (meth)acrylamide which comprises one sole (meth)acrylamido group, one sole tris(trimethylsiloxy)silyl group, and one polyethylene glycol segment which is either dangling polymer chain or a hydrophilic linker between the (meth)acrylamido group and the tris(trimethylsiloxy)silyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing (meth)acrylamido group, one tris(trimethylsiloxy)silyl group of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an amphiphilic siloxane-containing (meth)acrylamido group, one tris(trimethylsiloxy)silyl group of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention. 2. The amphiphilic siloxane-containing (meth)acrylamide of , being represented by formula (1) as defined in .3. The amphiphilic siloxane-containing (meth)acrylamide of claim 2 , wherein R′ is hydrogen; Ris hydrogen or methyl; Ris a linear or branched C-Calkylene divalent radical; Ris C-Calkoxy; Zand Zare a direct bond; Zis C-Calkylene divalent radical; Xis —O—CO—NH— or —O—CO—NH—R—NH—CO—O— in which Ris a linear or branched C-Calkylene divalent radical or a C-Ccycloaliphatic or aliphatic-cycloaliphatic divalent radical; q1 is an integer from 2 to 50.4. The amphiphilic siloxane-containing (meth)acrylamide of claim 2 , being represented by formula (1) as defined in .6. The amphiphilic siloxane-containing (meth)acrylamide of claim 1 , wherein the amphiphilic siloxane-containing (meth)acrylamide has a water solubility or dispersibility of at least about 5% by weight in water.7. A polymer comprising monomeric units derived from an amphiphilic siloxane- ...

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Номер записи: 49
19-06-2014 дата публикации

Amphiphilic siloxane-containing vinylic monomers and uses thereof

Номер: US20140171542A1
Автор: Frank Chang
Принадлежит: NOVARTIS AG

The invention provides an amphiphilic siloxane-containing vinylic monomer which comprises one sole ethylenically unsaturated group and a siloxane-containing group covalently linked to the ethylenically-unsaturated group through a hydrophilic linker. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing vinylic monomer of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an amphiphilic siloxane-containing vinylic monomer of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention.

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Номер записи: 50
19-06-2014 дата публикации

ACTINICALLY-CROSSLINKABLE AMPHIPHILIC PREPOLYMERS

Номер: US20140171543A1
Автор: Chang Frank, Shankernarayanan Manivakkam J.
Принадлежит: NOVARTIS AG

The invention provide a class of actinically-crosslinkable amphiphilic prepolymers which comprise at least one polysiloxane segment, at least one polyoxazoline segment, and two terminal ene groups. The present invention is also related to a medical device comprising a silicone hydrogel material obtained from step-growth polymerization of a polymerizable material comprising a prepolymer of the invention and to a method for producing contact lenses from a prepolymer of the invention. 2. The prepolymer of claim 1 , wherein the prepolymer of the invention is obtained by:{'sub': 1', '3', '1', '3', '1', '4', '1', '3', '2', '4', '1', '4', '1', '4', '1', '6', '1', '6, '(a) polymerizing a reactive mixture comprising at least one polysiloxane compound terminated with two first reactive functional groups, a polyoxazoline terminated with two second reactive functional groups and/or a polyoxazoline with one sole first reactive terminal group having two third reactive functional groups, and optionally a hydrophilic polymer with one sole second reactive terminal group having two fourth reactive functional groups, in the presence or absence of a coupling agent under coupling reaction conditions to form an intermediary copolymer terminated with two reactive functional groups which independently of each other are one of the first, second, third and fourth functional group, wherein the hydrophilic polymer comprises at least about 80% by weight of hydrophilic monomeric units selected from the group consisting of oxazoline units, ethyleneoxide units, (meth)acrylamide units, N—C-Calkyl(meth)acrylamide units, N,N-di-(C-Calkyl)(meth)acrylamide units, N-vinylpyrrole units, N-vinyl-2-pyrrolidone units, 4-vinylpyridine units, mono-C-Calkoxy mono-(meth)acryloyl terminated polyethyleneglycol units having a molecular weight of 600 Daltons or less, di(C-Calkyl amino)(C-Calkyl) (meth)acrylate units, N—C-Calkyl-3-methylene-2-pyrrolidone units, N—C-Calkyl-5-methylene-2-pyrrolidone units, N-vinyl C- ...

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Номер записи: 51
12-04-2018 дата публикации

POLYMERIZABLE POLYDIMETHYLSILOXANE-POLYOXYALKYLENE BLOCK COPOLYMERS

Номер: US20180100038A1
Автор: Chang Frank, Jing Feng
Принадлежит:

The invention provides a polymerizable polydimethylsiloxane-polyoxyalkylene block copolymer which comprises (1) a linear polymer chain comprising at least two polydimethylsiloxane segments, one hydrophilic polyoxyalkylene segment between each pair of polydimethylsiloxane segments, and one amide-rich linker between each pair of one polydimethylsiloxane segment and one hydrophilic polyoxyalkylene segment, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a weight average molecular weight of at least 3000 Daltons. The invention is also related to a silicone hydrogel contact lens produced from a polymerizable polydimethylsiloxane-polyoxyalkylene block copolymer of the invention. 2. The polymerizable polydimethylsiloxane-polyoxyalkylene block copolymer according to claim 1 , wherein p1 is zero.3. The polymerizable polydimethylsiloxane-polyoxyalkylene block copolymer according to claim 1 , wherein b1 is zero.4. The polymerizable polydimethylsiloxane-polyoxyalkylene block copolymer according to claim 1 , wherein p1 and b1 both are zero and e1 is an integer of from 10 to 100.6. The silicone hydrogel contact lens according to claim 5 , wherein the hydrophilic vinylic monomer is N-vinylpyrrolidone claim 5 , N claim 5 ,N-dimethyl (meth)acrylamide claim 5 , (meth)acrylamide claim 5 , hydroxylethyl (meth)acrylamide claim 5 , hydroxyethyl (meth)acrylate claim 5 , glycerol methacrylate (GMA) claim 5 , polyethylene glycol (meth)acrylate claim 5 , polyethylene glycol C-C-alkyl ether (meth)acrylate having a weight average molecular weight of up to 1500 claim 5 , N-vinyl formamide claim 5 , N-vinyl acetamide claim 5 , N-vinyl isopropylamide claim 5 , N-vinyl-N-methyl acetamide claim 5 , N-methyl-3-methylene-2-pyrrolidone claim 5 , 1-ethyl-3-methylene-2-pyrrolidone claim 5 , 1-methyl-5-methylene-2-pyrrolidone claim 5 , 1-ethyl-5-methylene-2-pyrrolidone claim 5 , 5-methyl-3-methylene-2-pyrrolidone claim 5 , 5-ethyl-3-methylene-2- ...

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Номер записи: 52
12-04-2018 дата публикации

CHAIN-EXTENDED POLYDIMETHYLSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF

Номер: US20180100053A1
Автор: Chang Frank, Jing Feng
Принадлежит:

The invention provides a chain-extended polydiorganosiloxane vinylic crosslinker which comprises (1) a polymer chain comprising at least two polydiorganosiloxane segments and one hydrophilized linker between each pair of polydiorganosiloxane segements, wherein each polydiorganosiloxane comprises at least 5 dimethylsiloxane units in a consecutive sequence, wherein the hydrophilized linker is a divalent radical having at least two (meth)acrylamide moieties; (2) two terminal (meth)acryloyl groups, wherein the chain-extended polydiorganosiloxane vinylic crosslinker has an average molecular weight of at least about 1500 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a chain-extended polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising a chain-extended polydiorganosiloxane vinylic crosslinker of the invention. 3. The chain-extended polydiorganosiloxane vinylic crosslinker according to claim 1 , wherein the chain-extended polydiorganosiloxane vinylic crosslinker is defined by formula (VI).4. The chain-extended polydiorganosiloxane vinylic crosslinker according to claim 1 , wherein the chain-extended polydiorganosiloxane vinylic crosslinker is defined by formula (VII).5. The chain-extended polydiorganosiloxane vinylic crosslinker according to claim 1 , wherein the chain-extended polydiorganosiloxane vinylic crosslinker is defined by formula (VIII).6. The chain-extended polydiorganosiloxane vinylic crosslinker according to claim 1 , wherein Yis a divalent radical of formula (III).7. The chain-extended polydiorganosiloxane vinylic crosslinker according to claim 1 , wherein Yis a divalent radical of formula (IV).8. The chain-extended polydiorganosiloxane vinylic crosslinker according to claim 1 , wherein the chain-extended polydiorganosiloxane vinylic ...

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Номер записи: 53
19-04-2018 дата публикации

HYDROPHILIC COPOLYMER WITH ONE THIOL-CONTAINING TERMINAL GROUP

Номер: US20180105619A1
Автор: Chang Frank, Holland Troy Vernon, Moy Thomas M.
Принадлежит:

The invention is related to a class of hydrophilic polymers each comprising one sole thiol-containing terminal group. The hydrophilic polymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses. 2. The hydrophilic polymer of claim 1 , wherein Ris hydrogen and Ris acetylamino claim 1 , propionylamino or butyrylamino.3. The hydrophilic polymer of claim 1 , wherein Ris hydrogen and Ris acetylamino or propionylamino.4. The hydrophilic polymer of claim 1 , wherein Ris hydrogen and Ris acetylamino.5. The hydrophilic polymer of claim 1 , wherein said one or more non-reactive hydrophilic vinylic monomer comprises a phosphorylcholine-containing vinylic monomer.6. The hydrophilic polymer of claim 1 , wherein said one or more non-reactive hydrophilic vinylic monomers comprises one member selected from the group consisting of (meth)acryamide claim 1 , N claim 1 ,N-dimethyl (meth)acrylamide claim 1 , N-vinylpyrrolidone claim 1 , N-vinyl-N-methyl acetamide claim 1 , glycerol (meth)acrylate claim 1 , hydroxyethyl (meth)acrylate claim 1 , N-hydroxyethyl (meth)acrylamide claim 1 , N-hydroxypropyl (meth)acrylamide claim 1 , C-C-alkoxy polyethylene glycol (meth)acrylate having a weight average molecular weight of up to 400 Daltons claim 1 , N-methyl-3-methylene-2-pyrrolidone claim 1 , 1-methyl-5-methylene-2-pyrrolidone claim 1 , 5-methyl-3-methylene-2-pyrrolidone claim 1 , N claim 1 ,N-dimethylaminoethyl (meth)acrylate claim 1 , N claim 1 ,N-dimethylaminopropyl (metha)crylamide claim 1 , and combinations thereof.7. The hydrophilic polymer of claim 1 , wherein the hydrophilic polymer comprises at least about 85% by mole of repeating units of said one or more non-reactive vinylic monomers.9. The water-soluble thermally-crosslinkable polymeric material of claim 8 , wherein the azetidinium ...

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Номер записи: 54
19-04-2018 дата публикации

Hydrophilic copolymer with pendant thiol groups

Номер: US20180105620A1
Автор: Feng Jing, Frank Chang, Ryan Desousa, Troy Vernon Holland
Принадлежит: NOVARTIS AG

The invention is related to a class of hydrophilic copolymers comprising loosely dangling thiol-containing pendant groups. The hydrophilic copolymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.

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Номер записи: 55
26-04-2018 дата публикации

Amphiphilic branched polydiorganosiloxane macromers

Номер: US20180113237A1
Автор: Fei Cheng, Feng Jing, Frank Chang, Ying Zheng
Принадлежит: NOVARTIS AG

The invention provides a class of amphiphilic branched polydiorganosiloxane macromers and the uses thereof. Such a macromer comprises a polydiorganosiloxane polymer chain and two terminal groups free of any ethylenically unsaturated group, wherein the polydiorganosiloxane polymer chain comprises (1) at least 5 dimethylsiloxane units in a consecutive sequence, (2) at least two first siloxane units each having methyl as one of the two substituents of each first siloxane unit and one first first organic radical having one sole (meth)acryloyl group as the other substituent, (3) at least one second siloxane unit having methyl as one of the two substituents of the second siloxane unit and one second organic radical, which is free of any ethylenically unsaturated group and comprises one or more hydrophilic groups or polymer chains, as the other substituent.

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Номер записи: 56
27-05-2021 дата публикации

SILICON METAL-OXIDE-SEMICONDUCTOR FIELD EFFECT TRANSISTOR (Si MOSFET) WITH A WIDE-BANDGAP III-V COMPOUND SEMICONDUCTOR GROUP DRAIN AND METHOD FOR FABRICATING THE SAME

Номер: US20210159338A1
Автор: CHANG EDWARD YI, Chang Mau-Chung Frank, CHUANG CHIEH-HSI, LIN JESSIE
Принадлежит:

A silicon metal-oxide-semiconductor field effect transistor with a wide-bandgap III-V compound semiconductor drain and a method for fabricating the same are disclosed. The method fabricates a hundred nanometer-scale hole in a (100) silicon substrate to expose the (111) facet of the silicon substrate, which favors to use selective area growth to form lattice matched III-V materials with high quality. 1. A silicon metal-oxide-semiconductor field effect transistor (MOSFET) with a wide-bandgap III-V compound semiconductor drain comprising:a substrate comprising a silicon substrate, and a semiconductor layer, the silicon substrate has a (100) facet as a main surface, the semiconductor layer is formed on the main surface;a dielectric layer formed on the semiconductor layer;a metal gate, having a first side and a second side opposite to the first side, formed on the dielectric layer;a source formed in the semiconductor layer below the metal gate and formed at the first side of the metal gate;a hundred nanometer-scale hole, formed at the second side of the metal gate, penetrating through the semiconductor layer to extend to within the silicon substrate, a wall surface of the hundred nanometer-scale hole is formed of a sidewall and an inclined surface connected with a bottom of the sidewall, the inclined surface has a (111) facet of the silicon substrate, and a buffer layer is formed on the inclined surface; anda III-V group drain formed in the hundred nanometer-scale hole.2. The silicon metal-oxide-semiconductor field effect transistor with a wide-bandgap III-V group drain according to claim 1 , wherein the substrate further comprising an insulation layer claim 1 , the insulation layer is formed between the silicon substrate and the semiconductor.3. The silicon metal-oxide-semiconductor field effect transistor with a wide-bandgap III-V group drain according to claim 2 , wherein the insulation layer is a SiN layer claim 2 , a SiOlayer claim 2 , or a multi-layer structure ...

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Номер записи: 57
12-05-2016 дата публикации

DIFFERENTIAL CURRENT MODE LOW LATENCY MODULATION AND DEMODULATION FOR CHIP-TO-CHIP CONNECTION

Номер: US20160134460A1
Автор: Chang Mau-Chung Frank, Cho Wei-Han, Kim Yanghyo, Lee Sheau Jiung
Принадлежит: The Regents of the University of California

A chip-to-chip communications circuit which is particularly well-suited for short range communication (less than a few inches) from one integrated circuit (chip) to another is presented. The circuits preferably utilize multi-frequency quadrature amplitude modulation (QAM) mechanisms for converting digital data bits from a parallel form into a serial analog stream for communication over a chip I/O connection. Differential current mode modulation in the transmitter, and demodulation in the receiver, are utilized which reduce latency and power-consumption while increasing manufacturing yields and resilience to process variations. 1. An apparatus for performing chip-to-chip communications , comprising:a modulation circuit and a demodulation circuit based on differential current flow, instead of absolute values of current, for communicating between a transmitting chip and a receiving chip;said modulation circuit including a digital-to-analog converter and current mode mixer for each of a plurality of data bits and one or more track pulses, each of said plurality of data bits is converted from a digital signal to an analog differential current and mixed in said current mode mixer with analog differential current outputs for other data bits during multi-frequency modulation in which the differential current is modulated in response to applying a frequency carrier at each of multiple frequencies in different current mode mixers in each modulator circuit; andsaid demodulation circuit including a current mode mixer and analog-to-digital converter for each of a plurality of data bits and one or more track pulses received from said modulation circuit, whereby a frequency carrier from said multiple frequencies is applied to each current mode mixer in said demodulator to demodulate the analog differential carrier prior to conversion back to a digital signal through said analog-to-digital converter.2. The apparatus recited in claim 1 , wherein a given number of parallel digital ...

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Номер записи: 58
01-09-2022 дата публикации

SILICONE HYDROGEL CONTACT LENSES

Номер: US20220275154A1
Автор: Breitkopf Richard Charles, Chang Frank, Ge Junhao, Jing Feng, Kumi Augustine Twum, Lang Weihong, Munoz Zach, Nelson Matthew D., Qian Xinming, Wu Daqing, Zhang Steve Yun, Zheng Ying
Принадлежит:

The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses. 147-. (canceled)51. The silicone hydrogel contact lens of claim 50 , wherein the siloxane-containing vinylic monomer is α-(meth)acryloxypropyl terminated ω-butyl (or ω-methyl) terminated polydimethylsiloxane claim 50 , α-(meth)acryloxy-2-hydroxypropyloxypropyl terminated ω-butyl (or ω-methyl) terminated polydimethylsiloxane claim 50 , α-(2-hydroxyl-methacryloxypropyloxy-propyl)-ω-butyl-decamethylpentasiloxane claim 50 , α-[3-(meth)acryloxyethoxy-2-hydroxypropyloxypropyl]-terminated ω-butyl (or ω-methyl) terminated polydimethylsiloxane claim 50 , α-[3-(meth)acryloxypropyloxy-2-hydroxypropyloxypropyl]-terminated ω-butyl (or ω-methyl) terminated polydimethylsiloxane claim 50 , α-[3-(meth)acryloxyisopropyloxy-2-hydroxypropyloxypropyl]-terminated ω-butyl (or w-methyl) terminated polydimethylsiloxane claim 50 , α-[3-(meth)acryloxybutyloxy-2-hydroxypropyloxypropyl]-terminated ω-butyl (or ω-methyl) terminated polydimethylsiloxane claim 50 , α-[3-(meth)acryloxyethylamino-2-hydroxypropyloxypropyl]-terminated ω-butyl (or ω-methyl) terminated polydimethylsiloxane claim 50 , α-[3-(meth)acryloxy-propylamino-2-hydroxypropyloxypropyl]-terminated ω-butyl (or ω-methyl) terminated polydimethylsiloxane claim 50 , α-[3-(meth)acryloxybutylamino-2-hydroxypropyloxypropyl]-terminated ω-butyl (or ω-methyl) terminated polydimethylsiloxane claim 50 , α-(meth)acryloxy-(polyethylenoxy)-2-hydroxypropyloxypropyl]-terminated ω-butyl (or ω-methyl) terminated polydimethylsiloxane claim 50 , α-[(meth)acryloxy-2-hydroxypropyloxy-ethoxypropyl]-terminated ω-butyl (or ω-methyl) terminated polydimethylsiloxane claim 50 , α-[(meth)acryloxy-2-hydroxypropyl-N-ethylaminopropyl]- ...

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Номер записи: 59
19-05-2016 дата публикации

COMPOSITIONS OF AND METHODS FOR USING HYDRAULIC FRACTURING FLUID FOR PETROLEUM PRODUCTION

Номер: US20160137910A1
Автор: Berger Paul D., CHANG Fakuen Frank, Lee Christie H., Mohapatra Susanta
Принадлежит:

A hydraulic fracturing fluid for use in oilfield applications is disclosed, the hydraulic fracturing fluid includes a spherical bead-forming liquid composition, the spherical bead-forming liquid composition comprised of a primary liquid precursor and a secondary liquid precursor, the primary liquid precursor comprises a micellar forming surfactant, a bead-forming compound, and a non-solids bearing liquid solvent; and the secondary liquid precursor comprises one or more curing agents, and one or more co-curing agents. 1. A hydraulic fracturing fluid for use in oilfield applications , the hydraulic fracturing fluid comprising: [ a micellar forming surfactant,', 'a bead-forming compound, and', 'a non-solids bearing liquid solvent; and, 'the primary liquid precursor comprises, a curing agent, and', 'a co-curing agent., 'the secondary liquid precursor comprises], 'a spherical bead-forming liquid composition, the spherical bead-forming liquid composition comprised of a primary liquid precursor and a secondary liquid precursor,'}2. The composition of claim 1 , where the primary liquid precursor further comprises an anti-foaming agent.3. The composition of claim 1 , where the primary liquid precursor further comprises a pH control agent.4. The composition of claim 1 , where the micellar forming surfactant is selected from the group consisting of anionic surfactants claim 1 , cationic surfactants claim 1 , nonionic surfactants claim 1 , amphoteric surfactants and combinations thereof.5. The composition of claim 1 , where the bead-forming compound is selected from the group consisting of bis-phenol A claim 1 , bis-phenol F claim 1 , cycloaliphatic epoxides claim 1 , glycidyl ethers claim 1 , poly glycidyl ethers claim 1 , novalac resins claim 1 , polyurethane resins claim 1 , acrylic resin claim 1 , phenol-formaldehyde resin claim 1 , epoxy functional resins claim 1 , and combinations thereof.6. The composition of claim 1 , where the non-solids bearing liquid solvent is ...

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Номер записи: 60
08-09-2022 дата публикации

METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES

Номер: US20220281193A1
Автор: Chang Frank, Tang Houliang
Принадлежит:

Described herein is a method for producing a contact lens comprising a central zone that has a diameter of about 13 mm or less, is concentric with the central axis of the contact lens, and possesses at least one photo functionality. The method comprises: applying a first polymerizable fluid composition containing at least one photochemically functional compound on a central portion of the molding surface of a female mold half to form a circular layer; partially curing, in situ, the circular layer in the female mold half; dispensing a second polymerizable fluid composition over the partially-cured circular layer on the molding surface of the female mold half; and a step of curing the second polymerizable fluid composition and the partially-cured circular layer immersed therein in the mold cavity formed between the the molding surfaces of the female mold half and a male mold half. 1. A method for producing hydrogel contact lenses , comprising the steps of:(1) obtain a first polymerizable fluid composition and a second polymerizable fluid composition, wherein the first polymerizable fluid composition comprises at least one photoinitiator and at least one polymerizable material and is free of any photochemically functional compound, wherein the second polymerizable fluid composition comprises said at least one photoinitiator and said at least one polymerizable material and additionally at least one photochemically functional compound, wherein difference in the concentration of each component of said at least one photoinitiator and said at least one polymerizable material between in the first polymerizable fluid composition and in the second polymerizable fluid composition is about 5.0% or less, wherein said at least one photochemically functional compound is at least one photochromic compound, at least one UV/HEVL absorbing compound, at least one fluorescent compound, at least one color-filtering material for correcting color blindness, at least one diffractive material ...

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Номер записи: 61
04-06-2015 дата публикации

POLYMERIZABLE CHAIN-EXTENDED POLYSILOXANES WITH PENDANT HYDROPHILIC GROUPS

Номер: US20150152228A1
Автор: Chang Frank, HUANG JINYU, Sanders Laura Ann
Принадлежит:

The invention provide a class of chain-extended polysiloxane crosslinkers which comprises (1) at least two polylsiloxane segments, wherein each pair of adjacent polysiloxane segments is linked by one divalent organic radical which includes at least one pendant hydrophilic group (hydroxyl and/or carboxyl groups) or at least one dangling hydrophilic polymer chain and a di-thioether linkage —S-DR-S— in which DR is a divalent oranic radical; and (2) two terminal ethylenically unsaturated groups. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer. 114-. (canceled)16. The prepolymer of claim 15 , wherein the hydrophilic polymer is selected from the group consisting of monofunctional group-terminated poly(ethylene glycol) (PEG) claim 15 , monofunctional group-terminated PEG/PPG block copolymers claim 15 , monofunctional group-terminated polyalkylacrylamides claim 15 , monofunctional group-terminated polyalkylmethacrylamides claim 15 , monofunctional group-terminated polyvinylpyrrolidones claim 15 , monofunctional group-terminated copolymers of N-vinylpyrrolidone with one or more vinylic monomers free of any reactive functional group claim 15 , monofunctional group-terminated polymer of one or more hydrophilic vinylic monomers free of reactive functional group other than ethylenuically unsaturated group claim 15 , and combinations thereof.17. The soluble amphiphilic prepolymer of claim 15 , wherein BG is (i) a linear or branched C-Calkylene divalent radical having at least one hydroxyl or carboxyl group or —OC(O)(CH)COOH in which t1 is an integer of 2 to 4 claim 15 , (ii) a divalent radical of —[CHCH(T)CHO]—[CH(R″)CHO]—[CHCH(T)CH]— in which R″ is H or methyl claim 15 , r3 is an integer of 1 to 20 claim 15 , T is hydroxyl or carboxyl group claim 15 , and r4 and r5 independent of each other are 0 or 1 claim 15 , or (iii) ...

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Номер записи: 62
26-05-2016 дата публикации

PHASE SYNCHRONIZATION OF MODULATION OR DEMODULATION FOR QAM-BASED MULTIBAND TSV-LINK

Номер: US20160149746A1
Автор: Chang Mau-Chung Frank, HO Wei-Han, Lee Sheau Jiung, Li Yilei
Принадлежит: The Regents of the University of California

A chip-to-chip communications circuit which is particularly well-suited for short range wired RF communication from one integrated circuit (chip) to another is presented. The circuits preferably utilize multi-frequency quadrature amplitude modulation (QAM) mechanisms for converting digital data bits from a parallel form into a serial analog stream for communication over a chip I/O connection. During a phase calibration cycle, a phase adjustment controller in the transmitter interoperates with a phase adjustment controller in the receiver, to adjust a phase locked-loop (PLL) circuit to correct for the phase delay arising in response to signal propagation between transmitter and receiver. 1. An apparatus for obtaining phase synchronization between modulation at a transmitter and demodulation at a receiver , comprising:(a) a modulation circuit within a transmitter configured for modulating digital data into a multiple-frequency analog signal output;(b) a demodulation circuit within a receiver configured for demodulating the multiple-frequency analog signal from said transmitter back into digital data;(c) a transmission controller coupled to said modulation circuit for controlling a phase adjustment cycle between said transmitter and said receiver; and(d) a phase adjustment controller coupled for receiving outputs from said demodulation circuit and for controlling phase of a phase-locked loop circuit coupled to multiple-frequency mixers in said demodulation circuit;(e) wherein during a phase adjustment cycle, predefined signal patterns are sent by said transmission controller to said phase adjustment controller, from which an optimum phase adjustment is determined for said phase-locked loop circuit controlling demodulation mixers in said demodulation circuit.2. The apparatus recited in claim 1 , wherein said phase adjustment controller is configured for validating correctness of demodulator output toward achieving maximum recovered signal strength based on performing ...

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Номер записи: 63
04-06-2015 дата публикации

AMPHIPHILIC POLYSILOXANE PREPOLYMERS AND USES THEREOF

Номер: US20150153482A1
Автор: Chang Frank, HUANG JINYU, Medina Arturo N., Pruitt John Dallas, Sanders Laura A., Scott Robert, Smith Dawn A.
Принадлежит:

The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses. 116-. (canceled)17. A silicone hydrogel contact lens comprising a polymeric material which is a polymerization product of a lens-forming composition including: [ [{'sub': 'Equivalent', '(a) a partially ethylenically-functionalized polysiloxane, wherein the partially ethylenically-functionalized polysiloxane is a mixture of reaction products obtained by reacting a first ethylenically functionalizing vinylic monomer having a first reactive functional group with a functional polysiloxane compound having two or more second reactive functional groups at a molar equivalent ratio, R, of from about 40% to about 95%, wherein each first reactive functional group reacts with one second reactive functional group in the presence or absence of a coupling agent to form a covalent bond or linkage, wherein the mixture of reaction product comprises at least one polysiloxane crosslinkers having at least two ethylenically unsaturated groups and at least one polysiloxane vinylic monomer or macromer having at least one second reactive functional group and at least one ethylenically unsaturated group,'}, '(b) at least one hydrophilic vinylic monomer,', '(c) ...

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Номер записи: 64
16-05-2019 дата публикации

TOUCHSCREEN WITH GROUP FILTERING

Номер: US20190146609A1
Автор: Chang Mau-Chung Frank, DU Li, Liu Chunchen, Zhang Yan
Принадлежит: The Regents of the University of California

A low-cost single-layer mobile touch-screen is disclosed, including a highly sensitive capacitive sensing circuit, and a corresponding finger 3D position estimation and gesture recognition algorithms compatible with mobile device platforms and that can be readily programmed into the mobile device's application processor. 1. A touch panel configured for touchless or multi-touch detection , comprising:an array of triangular shaped sensing electrodes disposed along a surface of the touch panel;the array of sensing electrodes comprising a plurality of upper electrodes and matching number of lower electrodes;wherein each upper electrode has an upper end disposed at or near an upper edge of the panel and a lower end disposed at or near a lower edge of the panel, and wherein the upper end has a width that decreases downward along the length of the upper electrode to form a point at the lower end;wherein each upper lower electrode has an upper end disposed at or near an upper edge of the panel and a lower end disposed at or near a lower edge of the panel, and wherein the lower end has a width that decreases upward along the length of the lower electrode to form a point at the upper end;wherein an output of each upper electrode is coupled to a dedicated upper response channel;wherein an output of each lower electrode is coupled to a dedicated lower response channel; andwherein a presence of a finger at or near the surface of the touch panel may be detected and located as a function of calculating a capacitance ratio of the upper channels and lower channels.2. The touch panel of :wherein each upper electrode and adjacent lower electrode form an electrode pair; andwherein each electrode pair is shaped and positioned to form an elongate rectangular swath substantially along a length between the upper edge and lower edge of the panel.3. The touch panel of claim 1 , wherein the electrodes are disposed within a single-layer on the touch panel.4. The touch panel of claim 1 , ...

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Номер записи: 65
08-06-2017 дата публикации

Water-soluble uv-absorbing compounds and uses thereof

Номер: US20170158611A1
Автор: Frank Chang, Ryan Desousa, Troy Vernon Holland, Walter R. Laredo
Принадлежит: NOVARTIS AG

Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.

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Номер записи: 66
24-06-2021 дата публикации

Intervertebral cage with porosity gradient

Номер: US20210186708A1
Автор: Chang Frank, Leong Steven, Robinson Scott, Vishnubhotla Sri
Принадлежит: Alphatec Spine, Inc.

An intervertebral cage with an outer frame, an open inner core region and a porosity gradient within the outer frame is provided. The outer frame includes a posterior wall, an anterior wall, a pair of side walls extending between the posterior wall and the anterior wall and the porosity gradient may comprise at least one of: a decreasing average pore diameter in a direction from an outer surface to an inner surface of at least one of the pair of side walls; an increasing average pore diameter in a direction from an outer surface to an inner surface of at least one of the pair of side walls; a decreasing average pore diameter in a direction from an upper surface to a lower surface of at least one of the side walls; and an increasing average pore diameter in a direction from an upper surface to a lower surface of at least one of the side walls. 1. An intervertebral cage comprising:an outer frame with an outer surface and an open inner core region defining an inner core surface, the outer frame further comprising superior and inferior surfaces and proximal and distal ends; anda porosity gradient within the outer frame with at least a portion of both the outer and inner core surfaces being porous;wherein the outer frame comprises a predefined and regular pattern of apertures that form the porosity gradient within the outer frame;wherein the superior and inferior surfaces each have a set of retention features; andwherein the intervertebral cage is shaped to facilitate placement of the intervertebral cage between two vertebrae.2. The intervertebral cage of claim 1 , wherein the outer frame comprises a plurality of layers with a predefined and regular pattern of apertures bonded to each other such that the predefined and regular pattern of apertures in each of the plurality of layers forms the porosity gradient within the outer frame.3. The intervertebral cage of claim 1 , wherein the outer frame comprises a plurality of bonded layers claim 1 , each layer having a ...

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Номер записи: 67
23-05-2019 дата публикации

POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS

Номер: US20190153141A1
Автор: Chang Frank, DeSousa Ryan, HUANG JINYU
Принадлежит:

The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C-Corganic substituent having two or three carboxy groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of greater than 3000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. 15-. (canceled)6. A silicone hydrogel contact lens comprising a crosslinked polymeric material which comprises:{'sub': 10', '50, 'units of a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C-Corganic substituent having at least two carboxy groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25 and (2) two terminal (meth)acryloyl groups, wherein the hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of at least about 3000 Daltons;'}units of a siloxane-containing vinylic monomer;units of at least one hydrophilic vinylic monomer; anda hydrophilic polymer which is not covalently attached onto the crosslinked polymeric material but is physically entrapped within the crosslinked polymeric ...

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Номер записи: 68
14-05-2020 дата публикации

TERAHERTZ SYSTEMS AND METHODS FOR MATERIALS IMAGING AND ANALYSIS

Номер: US20200150032A1
Автор: Al Hadi Richard, Chang Mau-Chung Frank, Zhao Yan
Принадлежит: The Regents of the University of California

An imaging device and method for evaluating and/or imaging material or chemical constituents of a sample. In one configuration, the imaging device includes a scanner having a terahertz wave transmitter configured to determine the amount of superabsorbent polymer (SAP) in the core of disposable hygiene product such as baby diapers, adult diapers and feminine hygiene pads, during the fabrication process. 1. An apparatus for detection of a composition or attribute of a sample material , comprising:a terahertz wave source comprising a linear array of emitters, each of the emitters being aligned to independently emit a radiation pattern at a specified terahertz wave frequency across an imaging region;a terahertz wave detector comprising a linear array of detectors, each of the detectors being aligned with a respective emitter of the terahertz wave source so as to individually receive the emitted radiation pattern of the respective emitter;wherein the terahertz wave source and terahertz wave detector are disposed adjacent the scanning region so as to allow for passage of a conveyance for moving the sample material through the imaging region;wherein one or more of the emitted radiation patterns are transmitted through or reflected from the sample material for reception by a respective detector in the terahertz wave detector.2. The apparatus of claim 1 , wherein the linear array of emitters is arranged in a line that is perpendicular to a direction of motion of the sample material.3. The apparatus of claim 1 , further comprising:a computer processor; andinstructions executable on the computer processor;wherein when executed said instructions determine one or more of an amount or distribution of a specified chemical or material of the sample material based on receipt of terahertz wave power received by said terahertz wave detector.4. The apparatus of claim 3 , wherein when executed said instructions further perform steps comprising:generating an image of the sample material; ...

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Номер записи: 69
15-06-2017 дата публикации

HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF

Номер: US20170166673A1
Автор: Chang Frank, HUANG JINYU, Jing Feng, Zhang Steve Yun
Принадлежит:

The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C-Corganic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. 1. A polydiorganosiloxane vinylic crosslinker , comprising: (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and siloxane unit having one methyl substituent and one monovalent C-Corganic radical substituent having two to six hydroxyl groups , wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15; (2) two terminal (meth)acryloyl groups , wherein the polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80 ,000 Daltons.3. The polydiorganosiloxane vinylic crosslinker of claim 2 , wherein Ris a monovalent radical of formula (2).5. The polydiorganosiloxane vinylic crosslinker of claim 2 , wherein Ris a monovalent radical of formula (3).7. The polydiorganosiloxane vinylic crosslinker of claim 2 , wherein Ris a monovalent radical of formula (4).9. The polydiorganosiloxane vinylic crosslinker of claim 2 , wherein Ris a monovalent radical of formula (5).11. The polydiorganosiloxane vinylic crosslinker of claim 2 , wherein Ris a monovalent radical of formula (6).12. The polydiorganosiloxane vinylic ...

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Номер записи: 70
15-06-2017 дата публикации

POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS

Номер: US20170166674A1
Автор: Chang Frank, DeSousa Ryan, HUANG JINYU
Принадлежит:

The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C-Corganic substituent having two or three carboxy groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of greater than 3000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. 1. A hydrophilized polydiorganosiloxane vinylic crosslinker , comprising: (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C-Corganic substituent having at least two carboxy groups , wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25; (2) two terminal (meth)acryloyl groups , wherein the hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of at least about 3000 Daltons.7. The silicone hydrogel contact lens of claim 6 , wherein the hydrophilic vinylic monomer is N-vinylpyrrolidone claim 6 , N claim 6 ,N-dimethyl (meth)acrylamide claim 6 , (meth)acrylamide claim 6 , hydroxylethyl (meth)acrylamide claim 6 , hydroxyethyl (meth)acrylate claim 6 , glycerol methacrylate (GMA) claim 6 , polyethylene glycol (meth)acrylate claim 6 , polyethylene glycol C-C-alkyl ether ( ...

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Номер записи: 71
15-06-2017 дата публикации

AMPHIPHILIC BRANCHED POLYDIORGANOSILOXANE MACROMERS

Номер: US20170166675A1
Автор: Chang Frank, Holland Troy Vernon, HUANG JINYU
Принадлежит:

The invention provides a class of amphiphilic branched macromers and the uses thereof. An amphiphilic branched polydiorganosiloxane macromer of the invention is produced from an α,ω-dimethacryloyl-terminated polydiorganosiloxane vinylic crosslinker comprising one or more ATRP-containing siloxane units having one substituent having an ATRP initiator by ATRP polymerization of one or more hydrophilic vinylic monomers. It comprises at least two polydiorganosiloxane polymer chains each having at most two terminal methacryloxy groups, dangling hydrophilic polymer chains each having a polymerizable or non-polymerizable terminal group, and one or more hydrophilic polymer chains as linkages between two polydiorganosiloxane chains. The present invention is also related to a silicone hydrogel contact lens, which comprises units derived from a polydiorganosiloxane-containing amphiphilic branched macromer of the invention. 1. An amphiphilic branched polydiorganosiloxane macromer , comprising:(1) at least first polydiorganosiloxane polymer chain having two terminal methacryloyl groups; and(2) at least one first hydrophilic chain;(3) at least one second hydrophilic polymer chain; and(4) at least one second polydiorganosiloxane polymer chain at least one end of which is covalently connected to the second hydrophilic polymer chain,wherein the first and second polydiorganosiloxane chains are derived from an α,ω-dimethacryloyl-terminated polydiorganosiloxane vinylic crosslinker comprising one or more ATRP-containing siloxane units having one substituent having an ATRP initiator,wherein the first hydrophilic chain is anchored covalently onto one single ATRP-containing siloxane unit of the first or second polydiorganosiloxane chain at one of the two ends of the first hydrophilic polymer chain and has one first terminal group at the other one of the two ends of the first hydrophilic polymer chain,wherein the second hydrophilic polymer chain is (a) anchored covalently onto one single ATRP ...

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Номер записи: 72
24-06-2021 дата публикации

SUB-THERMAL SPREAD SPECTRUM DATA-LINK

Номер: US20210194535A1
Автор: Chang Mau-Chung Frank, Huang Rulin, Tang Adrian J.
Принадлежит:

We have demonstrated that the bandwidth millimeter wavelengths offer can be leveraged to deeply spread a low-data rate signal below the thermal floor of the environment (sub-thermal) by lowered transmit power combined with free space losses, while still being successfully received through a novel dispreading structure which does not rely on pre-detection to extract timing information. The demonstrated data link ensures that it cannot be detected beyond a designed range from the transmitter, while still providing reliable communication. A demonstration chipset of this sub-thermal concept was implemented in a 28 nm CMOS technology and when combined with an InP receiver was shown to decode signals up to 30 dB below the thermal noise floor by spreading a 9600 bps signal over 1 GHz of RF bandwidth from 93 to 94 GHz using a 64 bit spreading code. The transmitter for this chipset consumed 62 mW while the receiver consumed 281 mw. 1. A receiver , comprising:an antenna receiving carrier electromagnetic radiation transmitted from a transmitter;a demodulator demodulating the carrier electromagnetic radiation to obtain a demodulated signal comprising a spread signal combined with thermal noise, the thermal noise having a thermal noise power spectral density (PSD), the spread signal formed from a signal using a spreading sequence applied to the signal in the transmitter, and the spreading sequence spreading a signal bandwidth of the signal to form the spread signal having a spread PSD smaller than the thermal noise PSD for all frequencies in the spread signal; andde-spreading circuitry:comparing the demodulated signal with a plurality of de-spreading sequences representing different timings of the spreading sequence with respect to the demodulated signal, to obtain a correlated signal comprising a correlation between the demodulated signal and one of the de-spreading sequences; andoutputting the correlated signal as the signal having a signal PSD greater than the thermal noise ...

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Номер записи: 73
29-09-2022 дата публикации

POLYSILOXANE VINYLIC CROSSLINKERS WITH HIGH REFRACTIVE INDEX

Номер: US20220306810A1
Автор: Chang Frank, Moy Thomas M., Sniady Adam K.
Принадлежит:

The invention provides a class of high RI polysiloxane vinylic crosslinkers. Each of the polysiloxane vinylic crosslinkers of the invention comprise (1) a polysiloxane segment comprising dimethylsiloxane units and aryl-containing siloxane units each having one methyl substituent and one organic substituent having up to 45 carbon atoms and at least one aryl moiety which is linked to Si atom through a linker having at least 2 (preferably 3) carbon atoms; (2) ethylenically-unsaturated groups. The invention also provides an insert or silicone hydrogel contact lens which comprises a crosslinked polymeric material comprising repeating units of at least one of such a class of high RI polysiloxane vinylic crosslinkers. 1. A polysiloxane vinylic crosslinker , comprising:(1) a polysiloxane segment comprising dimethylsiloxane units and aryl-containing siloxane unit having one methyl substituent and one organic substituent having up to 45 carbon atoms and at least one aryl moiety which is linked to Si atom through a linker having at least 2 carbon atoms; and(2) ethylenically-unsaturated groups.2. The polysiloxane vinylic crosslinker of claim 1 , wherein the polysiloxane vinylic crosslinker has a refractive index of at least 1.48 and a Tof about 0° C. or lower.3. The polysiloxane vinylic crosslinker of claim 2 , wherein the polysiloxane segment comprises at least 30% by mole of the aryl-containing siloxane units.4. The polysiloxane vinylic crosslinker of claim 3 , wherein the polysiloxane vinylic crosslinker has a number average molecular weight of at least 1000 Daltons.5. The polysiloxane vinylic crosslinker of claim 1 , wherein the polysiloxane segment comprises at least 30% by mole of the aryl-containing siloxane units.6. The polysiloxane vinylic crosslinker of claim 5 , wherein the polysiloxane vinylic crosslinker has a number average molecular weight of at least 1000 Daltons.8. The polysiloxane vinylic crosslinker of claim 7 , wherein in formula (1) ν1 is an integer of from ...

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Номер записи: 74
21-05-2020 дата публикации

CONTACT LENS WITH PHOSPHORYLCHOLINE-MODIFIED POLYVINYLALCOHOLS THEREIN

Номер: US20200158913A1
Автор: Chang Frank, Holland Troy Vernon, Sniady Adam K., Tang Houliang
Принадлежит:

The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating thereon and to a method for producing the same. The hydrogel lens body is composed of a crosslinked polymeric material comprising repeating units of at least one arylborono-containing vinylic monomer having a boronic acid group, and the coating comprises a layer of a phosphorylcholine-containing polymer which comprises (a) repeating units of vinyl alcohol, and (b) repeating units of 6-membered acetal ring substituted with a phosphorylcholine-containing group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one of the boronic acid groups of the crosslinked polymeric material and one of the 1,2-diol and 1,3-diol moieties of the phosphorylcholine-containing polymer. 1. A soft contact lens , comprising: a lens bulk material which is a crosslinked polymeric material having a polymer matrix; and at least one non-polymerizable preformed phosphorylcholine-containing polymer which each comprises (a) first repeating units of vinyl alcohol and/or vinyl acetate and (b) second repeating units of 6-membered acetal ring substituted with a phosphorylcholine-containing group , wherein the non-polymerizable preformed PC-containing polymer is not covalently attached to the crosslinked polymeric material and is distributed within the polymer matrix.3. The soft contact lens of claim 2 , wherein the soft contact lens comprises at least two non-polymerizable preformed phosphorylcholine-containing polymers claim 2 , wherein one of the two non-polymerizable preformed PC-containing polymers has a number-average molecular weight of from 10 claim 2 ,000 to 100 claim 2 ,000 Daltons while the other has a number-average molecular weight of from 200 claim 2 ,000 to 2 claim 2 ,000 claim 2 ,000.4. The soft contact lens of claim 3 , wherein the weight proportion of the two non-polymerizable preformed phosphorylcholine- ...

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Номер записи: 75
22-06-2017 дата публикации

POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS

Номер: US20170176643A1
Автор: Chang Frank, HUANG JINYU, Shankar Venkat
Принадлежит:

The invention provides an actinically-polymerizable amphiphilic polysiloxane which comprises a polysiloxane polymer chain comprising a polylsiloxane segments comprising at least one siloxane unit having a low molecular weight hydrophilic polymer chain connected with a silicone atom of the siloxane unit, and (meth)acrylamido groups each covalently bonded to one of the ends of the polysiloxane polymer chain and/or to the end of one of low molecular weight hydrophilic polymer chains each connected with one silicone atom. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises repeating units derived from an actinically-polymerizable amphiphilic polysiloxane of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an actinically-polymerizable amphiphilic polysiloxane of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention. 116-. (canceled)19. The method of claim 18 , further comprising the step of extracting the molded silicone hydrogel contact lens with water or an aqueous solution.23. The contact lens of claim 17 , wherein claim 17 , in formula (1) and (2) claim 17 , R claim 17 , R claim 17 , R claim 17 , R claim 17 , R claim 17 , R claim 17 , R claim 17 , R claim 17 , R claim 17 , R claim 17 , and Rare methyl.24. The contact lens of claim 17 , wherein claim 17 , in formula (1) and (2) claim 17 , hPC is a hydrophilic polymer segment composed of hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer selected from the group consisting of N-vinylpyrrolidone claim 17 , N claim 17 ,N-dimethyl (meth)acrylamide claim 17 , (meth)acrylamide claim 17 , N-vinyl formamide claim 17 , N-vinyl acetamide claim 17 , N-vinyl isopropylamide claim 17 , N-vinyl-N- ...

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Номер записи: 76
06-06-2019 дата публикации

FREQUENCY TRANSLATING BACKSCATTER MODULATOR WITH ENVELOPE CONTROL TO SUPPORT OFDM/QAM AND OTHER ENVELOPE MODULATED WIRELESS PROTOCOLS

Номер: US20190173728A1
Автор: Chang Mau-Chung Frank, Tang Adrian J.
Принадлежит:

A backscatter modulator for providing low power wireless communications. The disclosed modulator provides phase control for discriminating backscatter from the antenna versus other objects. In addition, the disclosed backscatter modulator provides amplitude modulation so that the technique can provide a non-constant envelope which can provide an intentional imbalance to manipulate super-position to provide envelope control of the reflected signal, while still maintaining the frequency translation properties. The disclosed backscatter modulator thus allows compatibility with QAM, OFDM and other non-constant envelope modulation schemes to be backscattered, while still supporting the frequency translation behavior. 1. A frequency translating backscatter modulator apparatus , comprising:a frequency divider configured with multiple carrier phase outputs;multiple amplitude control circuits, with each amplitude control circuit coupled for receiving one of said multiple carrier phase outputs and modulating its amplitude in response to receipt of an envelope control signal as received from multiple envelope control signals, and outputting an amplitude modulated switching control signal; andmultiple antenna termination switches, each of which is configured for having its switching state controlled in response to receiving one of said amplitude modulated switching control signals from said multiple amplitude control circuits;wherein each of said multiple antenna switches is connected in parallel and configured for connection to an antenna so that antenna termination impedance comprises superposition of multiple carrier phases from said multiple carrier phase outputs, and amplitude control from said envelope control signals.2. The apparatus of claim 1 , wherein said multiple carrier phase outputs comprise quadrature internal carrier phases.3. The apparatus of claim 1 , wherein said envelope control signal comprises a constant or a non-constant envelope modulation scheme.4. The ...

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Номер записи: 77
13-06-2019 дата публикации

Soft silicone medical devices

Номер: US20190177444A1
Автор: Frank Chang, Joseph Michael Lindacher, Robert Scott, Troy Vernon Holland, Uwe Haken, Xinming Qian
Принадлежит: NOVARTIS AG

The invention is related to a method for producing silicone medical devices, in particular, silicone contact lenses, having consistent mechanical properties in a cost-effective manner. The invention is also related to a silicone medical device, especially a soft silicone contact lens.

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Номер записи: 78
13-06-2019 дата публикации

HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF

Номер: US20190177460A1
Автор: Chang Frank, HUANG JINYU, Jing Feng, Zhang Steve Yun
Принадлежит:

The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C-Corganic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. 125-. (canceled)27. The silicone hydrogel contact lens of claim 26 , wherein in formula (1) Xis O.28. The silicone hydrogel contact lens of claim 27 , wherein in formula (1) ω1/ν1 is from about 0.040 to about 0.12.29. The silicone hydrogel contact lens of claim 28 , wherein in formula (6) n1 is 3 and q1 is 1.30. The silicone hydrogel contact lens of claim 29 , wherein the crosslinked polymeric material comprises units of at least one hydrophilic vinylic monomer.31. The silicone hydrogel contact lens of claim 30 , wherein said at least one hydrophilic vinylic monomer is selected from the group consisting of N-vinylpyrrolidone claim 30 , N claim 30 ,N-dimethyl (meth)acrylamide claim 30 , (meth)acrylamide claim 30 , N-hydroxyethyl (meth)acrylamide claim 30 , N-hydroxypropyl (meth)acrylamide claim 30 , hydroxyethyl (meth)acrylate claim 30 , glycerol methacrylate (GMA) claim 30 , polyethylene glycol (meth)acrylate having a number average molecular weight of up to 1500 claim 30 , polyethylene glycol C-C-alkyl ether (meth)acrylate having a number average molecular weight of up to 1500 claim 30 , N-[tris(hydroxymethyl)methyl]-acrylamide claim 30 , N- ...

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Номер записи: 79
13-06-2019 дата публикации

UV-ABSORBING VINYLIC MONOMERS AND USES THEREOF

Номер: US20190179170A1
Автор: Chang Frank, DeSousa Ryan, Holland Troy Vernon, Nelson Jared, Pruitt John Dallas
Принадлежит:

Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens. 2. The UV-absorbing vinylic monomer of claim 1 , being a vinylic monomer of formula (I).4. The UV-absorbing vinylic monomer of claim 1 , being a vinylic monomer of formula (II).6. The UV-absorbing vinylic monomer of claim 1 , being a vinylic monomer of formula (III).811-. (canceled)13. The hydrogel contact lens of claim 12 , wherein the hydrogel contact lens is a silicone hydrogel contact lens claim 12 , wherein the crosslinked polymeric material which comprises repeating units of at least one hydrophilic vinylic monomer and repeating units of at least one siloxane-containing vinylic monomer and/or macromer.14. The hydrogel contact lens of claim 12 , wherein the crosslinked polymeric material which comprises repeating units of an actinically-crosslinkable polyvinyl alcohol prepolymer.17. The method of claim 16 , wherein the free-radical initiator is a thermal initiator claim 16 , wherein the step of curing is carried out thermally.18. The method of claim 16 , wherein the free-radical initiator is a photoinitiator claim 16 , wherein the step of curing is carried out by irradiation with a light having a wavelength within the range from 380 nm to 500 nm. This application claims the benefits under 35 USC § 119 (e) of U.S. provisional application No. 62/298,137 filed 22 Feb. 2016, herein incorporated by reference in its entirety.This invention is related to water-soluble vinylic monomers capable of absorbing ultra-violet (UV) radiation and optionally high-energy-violet (HEVL) radiation and their uses for producing hydrogel contact lenses capable ...

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Номер записи: 80
06-07-2017 дата публикации

MICROWAVE REFLECTOR LINK, AND CDMA-SPREAD SPECTRUM REFLECTOR APPARATUS FOR REDUCTION OF UNMODULATED AMBIENT BLOCKERS IN REFLECTED DATA LINKS

Номер: US20170194713A1
Автор: Chahat Nacer, Chang Mau-Chung Frank, Kim Yanghyo, Tang Adrian
Принадлежит:

A system, apparatus and method are disclosed for communicating between a short range wireless (WLAN) user device, such as a wearable, phone, or tablet, with a base station. Traditional low power communication (e.g., WLAN, WiFi, Bluetooth, cellular links, etc.) involve an inefficient amplification process of a signal from the WLAN user to the base station, whereby significant power must be expended in the WLAN user device making it unsuitable in many applications. A reflector link paradigm is disclosed in which the user device communicates by modulating the extent of signal reflected back to the base station. An enhanced reflector is also disclosed which overcomes adverse effects of ambient reflections. 1. A microwave reflector link system for wireless local communication , the system comprising:(a) a microwave illuminator, said microwave illuminator including a microwave signal source as input to a power amplifier whose output is coupled to an antenna;(b) a microwave reflector, said microwave reflector including an antenna and a modulator coupled to said antenna; and(c) a microwave receiver;(d) wherein said microwave illuminator is configured to transmit power to said microwave reflector for illuminating or exciting said microwave reflector;(e) wherein said microwave reflector is configured to receive power from said microwave illuminator and to reflect or absorb that power as a function of termination state of its antenna, wherein the termination state of its antenna is controlled by said modulator, wherein said microwave reflector is configured to receive a broadband data input from said microwave illuminator and to reflect modulated data; and(f) wherein said microwave receiver is configured to receive modulated data reflected from said microwave reflector and convert the modulated data to broadband data.2. The system as recited in claim 1 , wherein said microwave reflector is configured for communicating data back to said microwave receiver without requiring a ...

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Номер записи: 81
21-07-2016 дата публикации

SYSTEM AND METHOD FOR PRODUCING BALLS IN THE ABSENCE OF INFLATION

Номер: US20160206929A1
Автор: CHANG Frank I Teh, YUAN Shao Ting
Принадлежит: Eternal Prowess Enterprise Co., Ltd.

The system and method of the present disclosure produces balls that conform in performance and dimensions or dimension range to inflated balls. In an exemplary embodiment of the present disclosure, the balls have a weight that is within a standard weight range of an inflated ball. In another exemplary embodiment of the present disclosure, the balls have a bounce characteristic that is within a standard bounce range of an inflated ball. In yet another exemplary embodiment of the present disclosure, the balls are tuned to achieve an audible response or sound characteristic that is similar to that of an equivalent inflated ball. It should be understood that an exemplary embodiment ball in accordance with the present disclosure can include any combination of features, or all features, including weight, dimensions, bounce, and sound or audible response when bounced. 1. A method of forming a ball , comprising:forming a first blocker and a second blocker, each of the first blocker and the second blocker configured to have a first density;heating each one the first blocker and the second blocker;compressing each one of the heated first blocker and the heated second blocker in a compression mold to increase the density of each one of the heated first blocker and the heated second blocker to a second density greater than the first density; andadhering the first blocker to the second blocker to form the ball.2. The method of claim 1 , further including adhering a plurality of decorative panels to an exterior surface of the ball.3. The method of claim 2 , wherein each one of the plurality of decorative panels is textured.4. The method of claim 2 , wherein the plurality of decorative panels includes one of a design claim 2 , an image claim 2 , and a picture.5. The method of claim 1 , wherein the each one of the first blocker and the second blocker is cooled after compressing and prior to release from the compression mold.6. The method of claim 1 , wherein each one of the first ...

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Номер записи: 82
27-06-2019 дата публикации

SENSITIVE DETECTION OF G-PROTEIN COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN 1 (GASP-1), GASP-1 MICROVESICLES, AND GASP-1 EXOSOMES

Номер: US20190195881A1
Автор: Chang Frank N., Luo Solomon, Tuszynski George P., Yang Jeff
Принадлежит: Proplex Technologies, LLC

A highly sensitive method of detecting GASP-1 or a fragment thereof in a sample is provided. The method comprises (a) exposing a surface to a sample comprising GASP-1 or a fragment thereof; (b) immobilizing an anti-GASP-1 antibody to the surface in the presence of the GASP-1 or a fragment thereof; (c) measuring the amount of the anti-GASP-1 antibody immobilized to the surface; and (d) determining the presence of the GASP-1 or a fragment thereof in the sample based on the amount of the anti-GASP-1 antibody immobilized to the surface. A coating agent may be immobilized to the surface in step (a), and the anti-GASP-1 antibody may be immobilized to the surface via the coating agent. The coating agent may be selected from the group consisting of a conjugate of bovine serum albumin (BSA) and a GASP-1 peptide (BSA-GASP-1 conjugate) a capture antibody against a microvesicle or exosomal surface biomarker, and a combination thereof. Also provided are kits for detecting GASP-1 or its fragment. 1. A method of detecting G protein coupled receptor-associated sorting 1 (GASP-1) or a fragment thereof in a sample , comprising:(a) exposing a surface to a sample comprising GASP-1 or a fragment thereof, wherein a coating agent is immobilized to the surface and is selected from the group consisting of a conjugate of bovine serum albumin (BSA) and a GASP-1 peptide (BSA-GASP-1 conjugate), a capture antibody against a microvesicle or exosomal surface biomarker, and a combination thereof;(b) immobilizing an anti-GASP-1 antibody to the surface via the coating agent in the presence of the GASP-1 or a fragment thereof;(c) measuring the amount of the anti-GASP-1 antibody immobilized to the surface; and(d) determining the presence of the GASP-1 or a fragment thereof in the sample based on the amount of the anti-GASP-1 antibody immobilized to the surface.2. The method of claim 1 , further comprising quantifying the concentration of the GASP-1 or a fragment thereof in the sample based on the ...

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Номер записи: 83
25-06-2020 дата публикации

HYDROPHILIC COPOLYMER WITH PENDANT THIOL GROUPS

Номер: US20200199269A1
Автор: Chang Frank, DeSousa Ryan, Holland Troy Vernon, Jing Feng
Принадлежит:

The invention is related to a class of hydrophilic copolymers comprising loosely dangling thiol-containing pendant groups. The hydrophilic copolymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses. 111-. (canceled)13. The water-soluble thermally-crosslinkable polymeric material of claim 12 , wherein the azetidinium-containing polymer is polyamidoamine-epichlorohydrin (PAE).14. The water-soluble thermally-crosslinkable polymeric material of claim 12 , wherein the azetidinium-containing polymer is a poly(2-oxazoline-co-ethyleneimine)-epichlorohydrin.15. The water-soluble thermally-crosslinkable polymeric material of claim 12 , wherein the azetidinium-containing polymer is a homopolymer of an azetidinium-containing vinylic monomer.16. The water-soluble thermally-crosslinkable polymeric material of claim 12 , wherein the azetidinium-containing polymer is a copolymer of an azetidinium-containing vinylic monomer with one or more hydrophilic vinylic monomers.17. The water-soluble thermally-crosslinkable polymeric material of claim 12 , wherein the water-soluble thermally-crosslinkable polymeric material comprises (i) from about 20% to about 95% by weight of the first polymer chains and (ii) from about 5% to about 80% by weight of the second polymer chains.18. A packaging solution claim 12 , which is an aqueous solution comprising:at least one buffering agent for maintaining a pH of from about 6.0 to about 8.5; and{'claim-ref': {'@idref': 'CLM-00012', 'claim 12'}, 'from about 0.01% to about 2% by weight of a water-soluble and thermally-crosslinkable hydrophilic polymeric material of ,'}wherein the packaging solution has a tonicity of from about 200 to about 450 milliosmol (mOsm) and a viscosity of from about 1 centipoise to about 20 centipoises at 25° C.19. The packaging ...

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Номер записи: 84
02-07-2020 дата публикации

COMPOSITIONS OF AND METHODS FOR USING HYDRAULIC FRACTURING FLUID FOR PETROLEUM PRODUCTION

Номер: US20200208046A1
Автор: Berger Paul D., CHANG Fakuen Frank, Lee Christie H.
Принадлежит:

A hydraulic fracturing fluid for use in oilfield applications, where hydraulic fracturing fluid includes a spherical bead-forming liquid composition, the spherical bead-forming liquid composition comprising a micellar forming surfactant, a bead-forming compound, a non-solids bearing liquid solvent, a pH control agent, and a curing agent. 1. A method of fracturing a reservoir with a hydraulic fracturing fluid formulation that generates fractures in the reservoir , the method comprising the steps of:mixing a primary liquid precursor and a secondary liquid precursor to form a spherical bead-forming liquid composition;pumping the spherical bead-forming liquid composition into an injection well in the reservoir at an external pressure greater than a pressure to generate fractures in the reservoir;allowing the spherical bead-forming liquid composition to migrate into the fractures of the reservoir; andallowing the primary liquid precursor and the secondary liquid precursor to react to form in situ solid, individual, spherical beads, where the solid, individual, spherical beads are formed from non-solids bearing liquids and are operable to keep the fractures open against an overburden pressure after the external pressure is released.2. The method of claim 1 , where the primary liquid precursor comprises a micellar forming surfactant.3. The method of claim 1 , where the primary liquid precursor comprises a bead-forming compound.4. The method of claim 1 , where the primary liquid precursor comprises a non-solids bearing liquid solvent.5. The method of claim 1 , where the primary liquid precursor comprises an anti-foaming agent.6. The method of claim 1 , where the primary liquid precursor comprises a pH control agent.7. The method of claim 1 , where the primary liquid precursor comprises a retarder.8. The method of claim 1 , where the secondary liquid precursor comprises a curing agent.9. The method of claim 1 , where the secondary liquid precursor comprises a co-curing agent ...

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Номер записи: 85
19-08-2021 дата публикации

MATRIX STIMULATION TOOL

Номер: US20210254442A1
Автор: Alali Eyad, CHANG Fakuen Frank, Roth Brian A., Sahu Qasim
Принадлежит:

A matrix stimulation tool includes a cylindrical tube; at least one piston disposed within the cylindrical tube and longitudinally moveable within the cylindrical tube; and at least one hollow tube coupled to the piston, the hollow tube including a distal end disposed within a hole disposed within a wall of the cylindrical tube. Movement of the piston within the cylindrical tube causes movement of the distal end of the at least one hollow tube through the hole. 1. A matrix stimulation tool system comprising:a tube disposed within a horizontal tunnel within a formation, the horizontal tunnel fluidly connected to a borehole disposed within the formation;at least one piston disposed within the tube, the piston longitudinally moveable within the tube, the piston comprising a generally cylindrical shape;at least one hollow tube coupled to the at least one piston, the at least one hollow tube comprising a distal end disposed within at least one hole disposed within a wall of the tube at an interface with the formation; andat least one valve disposed within the at least one piston, the at least one valve allowing a flow of fluid through the at least one piston in at least one direction,where fluid pressure on an upstream side of the at least one piston longitudinally pushes the at least one piston, thereby causing the at least one hollow tube to penetrate into the formation.2. The system of claim 1 , where the fluid pressure is caused by pumped acidizing solution claim 1 , andwhere the fluid comprises abrasive solids with an average diameter size ranging from about 0.01 mm to about 0.5 mm.3. The system of claim 2 , where the at least one hollow tube is from about five (5) to about thirty (30) feet in length claim 2 ,where the at least one hollow tube comprises an inner diameter from about 0.1 inch to about 0.5 inch, andwhere the abrasive solids comprise sand, metal particles, or both sand and metal particles, in spherical or platelet shapes.4. (canceled)5. The system of ...

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Номер записи: 86
25-07-2019 дата публикации

CAST-MOLDING PROCESS FOR PRODUCING UV-ABSORBING CONTACT LENSES

Номер: US20190225726A1
Автор: Chang Frank, DeSousa Ryan, Holland Troy Vernon
Принадлежит:

Described herein is a cast-molding process for producing contact lenses in a relatively-short curing time from a lens-forming composition, which comprises (a) at least one thiol-containing compound or component, (b) at least one metal scavenger, and (c) at least one free radical scavenger and which has a pH of from about 2.5 to about 5. The addition of a chain-transfer agent into a lens-forming composition can reduce not only the curing time of the lens-forming composition but also reduce the elastic modulus of resultant crosslinked materials (e.g., contact lenses) from the lens-forming composition. The lower pH and the addition of metal scavenger and the free radical scavenger into the lens-forming composition can ensure that the lens-forming composition to have a shelf life of at least three days. 1. A lens-forming composition , comprising:(a) at least one lens-forming material,(b) at least one photoinitiator,(c) at least one thiol-containing compound or polymer in an amount for reducing the curing time of the lens-forming composition, with a first light having a wavelength from about 380 to about 460 nm, compared to a control composition which differs from the lens-forming composition only in that the control composition is free of any chain-transfer agent while the lens-forming composition comprises said at least one thiol-containing compound or polymer,(d) at least one metal ion scavenger,(e) at least one free radical scavenger, and 'wherein the lens-forming composition has a pH of from about 2.5 to about 5 and a shelf life of at least 3 days.', '(f) optionally at least one polymerizable UV-absorbing component having at least one UV-absorbing moiety which absorbs UV radiation having a wavelength of from 200 nm to 400 nm,'}2. The lens-forming composition of claim 1 , wherein said at least one thiol-containing compound or polymer is selected from the group consisting of 2-mercaptoethylamine claim 1 , 2-mercaptopropylamine claim 1 , 3-mercaptopropylamine claim 1 , ...

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Номер записи: 87
25-07-2019 дата публикации

Coated Silica Particles

Номер: US20190225868A1
Автор: CHANG Fakuen Frank, Kalgaonkar Rajendra Arunkumar
Принадлежит: Saudi Arabian Oil Company

The present application relates to coated silica particles, compositions containing the coated silica particles, and methods for using these compositions in subterranean formations. The coated silica particle includes a cationic species non-covalently bound to an outer surface of the particle. The particle can include a nanoparticle. 1. A method of consolidating an incompetent subterranean formation , the method comprising contacting an incompetent formation with a hardenable delayed-gelling composition comprising a coated silica particle comprising a cationic species non-covalently bound to an outer surface of the particle , to obtain a consolidated mass of subterranean particles.2. The method of claim 1 , wherein the silica particle is a nanoparticle comprising a diameter from about 5 nm to about 50 nm.3. The method of claim 1 , wherein the cationic species is a cationic polymer selected from the group consisting of poly(2-hydroxypropyl-1-N-dimethylammonium chloride) claim 1 , poly(2-hydroxypropyl-1-1-N-dimethylammoniumchloride) claim 1 , poly[N-(dimethylaminomethyl)]-acrylamide claim 1 , poly(2-vinylimidazolinium bisulfate) claim 1 , poly(diallyldimethylammoniumchloride) claim 1 , poly(N-dimethylaminopropyl)-methacrylamide claim 1 , and combinations thereof.4. The method of claim 3 , wherein an amount of the cationic polymer relative to the weight of the silica particles in the composition ranges from about 5 wt. % to about 20 wt. %.5. The method of claim 5 , wherein the non-covalent binding between the cationic polymer and the outer surface of the silica particle comprises an electrostatic interaction between negatively charged silanol groups or silyloxy anions on the outer surface of the silica particle and the positively charged cationic polymer.6. The method of claim 6 , wherein the hardenable delayed-gelling composition comprises water and an amount of the particulate material in the composition is from about 10 wt. % to about 50 wt. %.7. The method of claim ...

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Номер записи: 88
25-07-2019 дата публикации

METHOD OF PRODUCING FROM A HYDROCARBON BEARING ZONE WITH LATERALS EXTENDING FROM AN INCLINED MAIN BORE

Номер: US20190226306A1
Автор: CHANG Fakuen Frank, Noui-Mehidi Mohamed Nabil
Принадлежит: Saudi Arabian Oil Company

A main bore is drilled with an inclined section extending toward a hydrocarbon bearing earth formation. First and second laterals are drilled from the inclined section downward into the formation at a steeper angles than the inclined section. The first lateral is opened to the formation at a depth greater than a depth of an opening of the second lateral. After completion, well fluid flows through the openings in the first and second laterals into the inclined section of the main bore. In response to an increasing water content in the well fluid flowing up the main bore, the flow of well fluid from the first lateral is restricted. 1. A method of wellbore operations comprising:drilling a main bore with an inclined section extending toward an earth formation;drilling first and second laterals from the inclined section, each extending downward from the inclined section into the formation;providing an opening in the first lateral and an opening in the second lateral, the opening in the first lateral extending to a greater depth than the opening in the second lateral;flowing well fluid through the openings in the laterals into the inclined section of the main bore; andselectively restricting the flow through the opening of the first lateral relative to the flow from the opening of the second lateral in the event a water content in the well fluid flowing from the opening in the first lateral exceeds a water content in the well fluid flowing from the second lateral by a selected amount.2. The method of claim 1 , where drilling first and second laterals comprises inclining each of the laterals at a greater angle relative to horizontal than the inclined section of the main bore.3. The method of claim 1 , where drilling first and second laterals comprises spacing the first and second laterals apart from each other along a length of the inclined section.4. The method of claim 1 , where drilling first and second laterals comprises inclining each of the laterals at an angle in a ...

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Номер записи: 89
16-07-2020 дата публикации

SENSITIVE DETECTION OF G-PROTEIN COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN 1 (GASP-1), GASP-1 MICROVESICLES, AND GASP-1 EXOSOMES

Номер: US20200225235A1
Автор: Chang Frank N., Luo Solomon, Tuszynski George P., Yang Jeff
Принадлежит: Proplex Technologies, LLC

A highly sensitive method of detecting GASP-1 or a fragment thereof in a sample is provided. The method comprises (a) exposing a surface to a sample comprising GASP-1 or a fragment thereof; (b) immobilizing an anti-GASP-1 detection antibody to the surface; (c) measuring the amount of the anti-GASP-1 detection antibody immobilized to the surface; and (d) determining the presence of the GASP-1 or a fragment thereof in the sample based on the amount of the anti-GASP-1 detection antibody immobilized to the surface. A coating agent may be immobilized to the surface in step (a), and the anti-GASP-1 detection antibody may be immobilized to the surface via the coating agent, directly or indirectly. The coating agent may be selected from the group consisting of a first GASP-1 fragment, a conjugate of a protein (e.g., bovine serum albumin (BSA)) and a GASP-1 peptide, a capture antibody against a microvesicle or exosomal surface biomarker, a capture antibody against a second GASP-1 fragment, and a combination thereof. Also provided are kits for detecting GASP-1 or its fragment. 1. A method of detecting G protein coupled receptor-associated sorting 1 (GASP-1) or a fragment thereof in a sample , comprising:(a) exposing a surface to a sample comprising GASP-1 or a fragment thereof, wherein a coating agent is immobilized to the surface and is selected from the group consisting of a first GASP-1 fragment, a conjugate of a protein and the first GASP-1 fragment, a capture antibody against a microvesicle or exosomal surface biomarker, a capture antibody against a second GASP-1 fragment, and a combination thereof, wherein the first and second GASP-1 fragments are different;(b) adding an anti-GASP-1 detection antibody against the first GASP-1 fragment, wherein the anti-GASP-1 detection antibody has a concentration of 0.01-1 ng/ml, whereby the anti-GASP-1 detection antibody is immobilized to the surface via the coating agent;(c) measuring the amount of the anti-GASP-1 detection antibody ...

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Номер записи: 90
24-08-2017 дата публикации

SOFT SILICONE MEDICAL DEVICES

Номер: US20170240658A1
Автор: Chang Frank, Haken Uwe, Holland Troy Vernon, Lindacher Joseph Michael, Qian Xinming, Scott Robert
Принадлежит:

The invention is related to a method for producing silicone medical devices, in particular, silicone contact lenses, having consistent mechanical properties in a cost-effective manner. The invention is also related to a silicone medical device, especially a soft silicone contact lens. 1. A method for producing a silicone medical device , comprising the steps of: (a) from about 65% to about 98.9% by weight of (i) one or more first polydiorganosiloxanes each having at least two (meth)acryloylamido groups, (ii) one or more second polydiorganosiloxanes each having at least two (meth)acryloyloxy groups, or (iii) a mixture thereof, wherein each of the first and second polydiorganosiloxanes has an averaged molecular weight of at least about 2000 Daltons,', '(b) from about 1.0% to about 20.0% by weight of one or more third polydiorganosiloxanes each having at least two thiol groups and an averaged molecular weight of at least about 2000 Daltons, and', '(c) from about 0.1% to about 3% by weight of a free-radical initiator,', 'provided that components (a) to (c) listed above and any additional polymerizable components present in the polymerizable silicone composition add up to 100% by weight;, '(1) obtaining a polymerizable silicone composition which comprises'}(2) introducing the polymerizable silicone composition into a mold for making a silicone medical device; and(3) curing thermally or actinically the polymerizable silicone composition in the mold to form the silicone medical device,wherein the formed silicone medical device has an elastic modulus of about 1.2 MPa or less and an elongation at break of about 200% or larger.2. The method of claim 1 , wherein the first claim 1 , second claim 1 , and third polydiorganosiloxanes independent of one another are a linear polydiorganosiloxane.3. The method of claim 1 , wherein the first claim 1 , second claim 1 , and third polydiorganosiloxanes independent of one another are a linear polydimethylsiloxane.4. The method of claim 3 ...

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Номер записи: 91
24-08-2017 дата публикации

UV/VISIBLE-ABSORBING VINYLIC MONOMERS AND USES THEREOF

Номер: US20170242274A1
Автор: Chang Frank, DeSousa Ryan, Holland Troy Vernon, Jiang Xuwei, Laredo Walter R.
Принадлежит:

Described herein are UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. 2. The UV-absorbing vinylic monomer of claim 1 , wherein only one of Rand Rcontains a (meth)acryloylamido group.3. The UV-absorbing vinylic monomer of claim 1 , wherein only one of Rand Rcontains a (meth)acryloyloxy group.5. A contact lens comprising a crosslinked material which comprises monomeric units of a UV-absorbing vinylic monomer of .6. The contact lens of claim 5 , wherein in formula (I) only one of Rand Rcontains a (meth)acryloylamido group.7. The contact lens of claim 5 , wherein in formula (I) only one of Rand Rcontains a (meth)acryloyloxy group.8. The contact lens of claim 5 , wherein in formula (I) only one of Rand Rcontains a (meth)acryloyloxy group.10. The contact lens of claim 5 , wherein the contact lens is a hydrogel contact lens.11. The contact lens of claim 5 , wherein the contact lens is a silicone hydrogel contact lens.12. The contact lens of claim 5 , wherein the contact lens has: an UVB transmittance of about 10% or less between 280 and 315 nanometers; a UVA transmittance of about 30% or less between 315 and 380 nanometers; a Violet transmittance of about 60% or less between 380 nm and 440 nm; and a water content of from about 15% to about 80% by weight (at room temperature claim 5 , about 22° C. to 28° C.) when being fully hydrated.13. A method for producing UV-absorbing contact lenses claim 5 , comprising the steps of:{'claim-ref': [{'@idref': 'CLM-00001', 'claims 1'}, {'@idref': 'CLM-00004', '4'}], '(1) obtaining a lens formulation comprising (a) a UV-absorbing vinylic monomer of formula (I) of any one of to , (b) a free-radical initiator, and (c) at least one polymerizable component selected from the group ...

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Номер записи: 92
24-08-2017 дата публикации

UV-ABSORBING VINYLIC MONOMERS AND USES THEREOF

Номер: US20170242275A1
Автор: Chang Frank, DeSousa Ryan, Holland Troy Vernon, Nelson Jared, Pruitt John Dallas
Принадлежит:

Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens. 2. The UV-absorbing vinylic monomer of claim 1 , being a vinylic monomer of formula (I).4. The UV-absorbing vinylic monomer of claim 1 , being a vinylic monomer of formula (II).6. The UV-absorbing vinylic monomer of claim 1 , being a vinylic monomer of formula (III).8. The UV-absorbing vinylic monomer of claim 1 , being a vinylic monomer of formula (IV) or (V).10. The UV-absorbing vinylic monomer of claim 1 , being a vinylic monomer of formula (VI) or (VII).12. A hydrogel contact lens claim 1 , comprising a crosslinked polymeric material which comprises repeating units of a UV-absorbing vinylic monomer of claim 1 , wherein the hydrogel contact lens has: an UVB transmittance (designated as UVB % T) of about 10% or less between 280 and 315 nanometers; an UVA transmittance (designated as UVA % T) of about 30% or less between 315 and 380 nanometers; optionally a Violet transmittance (designated as Violet % T) of about 60% or less between 380 nm and 440 nm; and a water content of from about 15% to about 80% by weight (at room temperature claim 1 , about 22° C. to 28° C.) when being fully hydrated.13. The hydrogel contact lens of claim 12 , wherein the hydrogel contact lens is a silicone hydrogel contact lens claim 12 , wherein the crosslinked polymeric material which comprises repeating units of at least one hydrophilic vinylic monomer and repeating units of at least one siloxane-containing vinylic monomer and/or macromer.14. The hydrogel contact lens of claim 12 , wherein the crosslinked polymeric material which comprises repeating units of an ...

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Номер записи: 93
01-08-2019 дата публикации

CONTACT LENSES WITH A LUBRICIOUS COATING THEREON

Номер: US20190235277A1
Автор: Breitkopf Richard Charles, Chang Frank, Ge Junhao, Gubitosi Raspino Maria F., Holland Troy Vernon, Lang Weihong, Moy Thomas M., Wu Daqing, Zhang Steve Yun
Принадлежит:

The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating of a hydrophilic copolymer thereon and to a method for producing the same. The hydrogel lens body comprises or is made of a polymeric material having 1,2- and/or 1,3-diol moieties, and the hydrophilic copolymer comprises arylborono-containing repeating units each having a boronic acid group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one boronic acid group and one 1,2-diol or 1,3-diol group. The soft contact lens has a surface lubricity higher than the surface lubricity of the lens body. 2. The soft contact lens of claim 1 , wherein the soft contact lens has a friction rating of about 2.5 or lower.3. The soft contact lens of claim 1 , wherein the soft contact lens has a friction rating of about 2.0 or lower.4. The soft contact lens of claim 1 , wherein the soft contact lens has a friction rating of about 1.5 or lower.5. The soft contact lens of claim 1 , wherein the soft contact lens has a friction rating of about 1.0 or lower.6. The soft contact lens of claim 2 , wherein the soft contact lens has an equilibrium water content of from about 15% to about 80% by weight at a temperature of from about 22° C. to 28° C. claim 2 , and/or an elastic modulus of from about 0.2 MPa to about 1.5 MPa when being fully hydrated.7. The soft contact lens of claim 6 , wherein the hydrogel lens body comprises or is made of a polymeric material comprising at least 50% by mole of repeating units of vinyl alcohol.9. The soft contact lens of claim 8 , wherein the polyvinylalcohol prepolymer has a weight average molecular weight of at least about 2 claim 8 ,000 Daltons claim 8 , and comprises from about 1% to about 25% by mole of the repeating units of formula (I).11. The soft contact lens of claim 8 , wherein said at least one arylborono-containing vinylic monomer is selected from the group consisting of 3- ...

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Номер записи: 94
07-09-2017 дата публикации

Hydrophilized carbosiloxane vinylic monomers

Номер: US20170254927A1
Автор: Frank Chang, Jinyu Huang
Принадлежит: NOVARTIS AG

The invention provides a hydrophilized carbosiloxane vinylic monomer which comprises (1) a poly(carbosiloxane) segment, (2) one sole ethylenically unsaturated group, and (3) at least one terminal or pendant group which is a hydrophilic group or hydrophilic polymer chain. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from a hydrophilized carbosiloxane vinylic monomer of the invention.

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Номер записи: 95
24-09-2015 дата публикации

Game Ball and Method for Making Game Ball

Номер: US20150265883A1
Автор: Bulfin Roy, Chang Frank, Lepere Patrick
Принадлежит: ZWYXIS HONGKONG CO LTD.

The invention discloses a method of making a game ball. The method comprises utilizing a mold to form a game ball section. The patterned surface is imprinted into the surface of the molded game ball section. The mold is utilized to create a plurality of grooves in the outer surface of the molded game ball section. The plurality of grooves creates a strength and resiliency in the molded game ball section. One or more molded game ball sections are combined edge to edge to create a final game ball. The mold used can be a male mold or a female mold. The molded game ball section can be made through vacuum forming, compression molding, or injection molding. 1. A method of making a game ball comprisinga. Selecting a blank of material;b. Heating said blank of material; i. Said mold having a contoured face;', 1. Wherein said hexagonal shapes and said pentagonal shapes are situated in a predetermined pattern;', '2. Wherein said border sections comprises a first bevel area, a second bevel area, and a groove disposed between said first bevel area and said second bevel area;, 'ii. Said contoured face comprising a plurality of hexagonal shapes, a plurality of pentagonal shapes, and a plurality of border sections, each of said border sections disposed between two of said shapes'}], 'c. Putting said blank of material into a mold'}d. Deforming said blank of material;e. Transferring said shape of said contoured face into said deformed blank of material; i. Creating a plurality of pentagonal shapes in the outer surface of said molded game ball section with said contoured face of said mold;', 'ii. Creating a plurality of hexagonal shapes in the outer surface of said molded game ball section with said contoured face of said mold;', 'iii. Creating a plurality of border sections disposed between two shapes in the outer surface of said molded game ball section with said contoured face of said mold;', 'iv. Creating a pair of bevel sections within each of said border sections in the outer ...

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Номер записи: 96
27-11-2014 дата публикации

CHAIN-EXTENDED POLYSILOXANE CROSSLINKERS WITH DANGLING HYDROPHILIC POLYMER CHAINS

Номер: US20140350124A1
Автор: Chang Frank, HUANG JINYU, Kuyu Selma, Medina Arturo Norberto, Scott Robert, Shankar Venkat, Smith Dawn Alison
Принадлежит:

The invention provide a class of linear chain-extended polysiloxane crosslinkers which comprises two terminal ethylenically unsaturated groups, at least two polysiloxane segments, and dangling hydrophilic polymer chains each covalently attached to a divalent organic radical separating each pair of adjacent polysiloxane segments. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer. 111-. (canceled)13. The prepolymer of claim 12 , which is obtained by first polymerizing a polymerizable composition including (a) said at least one chain-extended polysiloxane crosslinker claim 12 , (b) at least one hydrophilic vinylic monomer claim 12 , (c) a chain transfer agent with or without a fourth reactive functional group other than thiol group and/or a vinylic monomer having a fifth reactive functional group other than ethylenically unsaturated group claim 12 , (d) optionally a hydrophobic vinylic monomer claim 12 , and (e) optionally a polymerizable UV-absorbing agent claim 12 , to form an intermediary copolymer and then by ethylenically functionalizing the intermediary copolymer with an ethylenically functionalizing vinylic monomer having a sixth reactive functional group capable of reacting with the first or second reactive functional group to form a linkage in a coupling reaction in the presence or absence of a coupling agent to form the prepolymer claim 12 , wherein the fourth claim 12 , fifth and sixth reactive functional groups independent of one another are selected from the group consisting of amino group —NHR′— with R′ as defined above claim 12 , hydroxyl group claim 12 , carboxyl group claim 12 , acid halide group claim 12 , azlactone group claim 12 , isocyanate group claim 12 , epoxy group claim 12 , aziridine group claim 12 , and combination thereof.14. The prepolymer of claim 12 , which is obtained by first ...

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Номер записи: 97
04-12-2014 дата публикации

METHOD FOR DETERMINING THE SURFACE CONCENTRATION OF CARBOXYL GROUPS ON A LENS

Номер: US20140356965A1
Автор: Chang Frank, Holland Troy Vernon, Qian Xinming, Qiu Yongxing, Shankar Venkat
Принадлежит: NOVARTIS AG

The invention is related to a method for qualifying and quantifying carboxyl groups on the surfaces of a silicone hydrogel contact lens. The method of the invention comprises the steps of: (a) obtaining silicone hydrogel contact lenses each of which comprises a silicone hydrogel lens body (i.e., bulk material) and a coating thereon, wherein the silicone hydrogel lens body is obtained from a lens formulation free of any polymerizable component including one or more carboxyl groups, wherein the coating comprises a polymer having carboxyl groups; (b) immersing a given number of the silicone hydrogel contact lenses in a fixed volume of a C-Calcohol solution of a positively-charged dye having acetate as counter anion at a given initial concentration for a time period sufficient to stain the silicone hydrogel contact lens; and (c) determining the concentration of carboxyl groups per each silicone hydrogel contact lens and/or the thickness of the coating on the silicone hydrogel contact lens. 1. A method for qualifying and quantifying carboxyl groups on the surfaces of a silicone hydrogel contact lens , comprising the steps of:(a) obtaining silicone hydrogel contact lenses each of which comprises a silicone hydrogel lens body and a coating thereon, wherein the silicone hydrogel lens body is obtained from a lens formulation free of any polymerizable component including one or more carboxyl groups, wherein the coating comprises a polymer having carboxyl groups;{'sub': 1', '4, '(b) immersing a given number of the silicone hydrogel contact lenses in a fixed volume of a C-Calcohol solution of a positively-charged dye having acetate as counter anion at a given initial concentration for a time period sufficient to stain the silicone hydrogel contact lens; and'}(c) determining the concentration of carboxyl groups per each silicone hydrogel contact lens and/or the thickness of the coating on the silicone hydrogel contact lens.2. The method of claim 1 , wherein the positively- ...

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Номер записи: 98
22-08-2019 дата публикации

Water-soluble uv-absorbing compounds and uses thereof

Номер: US20190256455A1
Автор: Frank Chang, Ryan Desousa, Troy Vernon Holland, Walter R. Laredo
Принадлежит: NOVARTIS AG

Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.

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Номер записи: 99
20-09-2018 дата публикации

Intervertebral cage with porosity gradient

Номер: US20180263785A1
Автор: Frank Chang, Scott Robinson, Sri VISHNUBHOTLA, Steven Leong
Принадлежит: Alphatec Spine Inc

An intervertebral cage with an outer frame, an open inner core region and a porosity gradient within the outer frame is provided. The outer frame includes a posterior wall, an anterior wall, a pair of side walls extending between the posterior wall and the anterior wall and the porosity gradient may comprise at least one of: a decreasing average pore diameter in a direction from an outer surface to an inner surface of at least one of the pair of side walls; an increasing average pore diameter in a direction from an outer surface to an inner surface of at least one of the pair of side walls; a decreasing average pore diameter in a direction from an upper surface to a lower surface of at least one of the side walls; and an increasing average pore diameter in a direction from an upper surface to a lower surface of at least one of the side walls.

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Номер записи: 100