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12-01-2012 дата публикации

Molds used to produce pva hydrogel implants and related implants

Номер: US20120010712A1

Принадлежит: Individual

Methods of fabricating elastomeric implants employ a mold with PVA crystals and irrigant added to the mold independent of each other. Related molds are also described.

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Номер записи: 1

02-02-2012 дата публикации

Sequentially cross-linked polyethylene

Номер: US20120029160A1

Автор: Aaron Essner, Aiguo Wang, John H. Dumbleton, Shi-Shen Yau

Принадлежит: Howmedica Osteonics Corp

A method of producing an improved polyethylene, especially an ultra-high molecular weight polyethylene utilizes a sequential irradiation and annealing process to form a highly cross-linked polyethylene material. The use of sequential irradiation followed by sequential annealing after each irradiation allows each dose of irradiation in the series of doses to be relatively low while achieving a total dose which is sufficiently high to cross-link the material. The process may either be applied to a preformed material such as a rod or bar or sheet made from polyethylene resin or may be applied to a finished polyethylene part.

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Номер записи: 2

02-02-2012 дата публикации

Osteoarthritis treatment and device

Номер: US20120029522A1

Автор: Charles F. Leinberry, Peter F. Sharkey

Принадлежит: Knee Creations LLC

A method for treating arthritis of a joint includes identifying a bone lesion in a bone adjacent to the joint; and implanting in the bone a reinforcing member in or adjacent to the bone lesion. A kit for conducting the method includes: (a) at least one reinforcing member having a proximal face adapted to face the joint, a distal face adapted to face away from the joint, and a wedge-shaped edge adapted to pierce bone, wherein the at least one reinforcing member is planar and sterile; and (b) a container adapted to maintain the at least one reinforcing member sterile. Another kit includes: (a) a sterile fluid; (b) a syringe for injecting the fluid into a bone; (c) a curing agent adapted to cure the fluid to polymerize and/or cross-link; and (d) a container adapted to maintain the sterility of contents of the container.

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Номер записи: 3

09-02-2012 дата публикации

Nanohybrid polymers for ophthalmic applications

Номер: US20120035337A1

Автор: Anthony Keslinke, Kevin Phan, Khalid Mentak

Принадлежит: Key Medical Technologies Inc

The present invention relates to novel materials particularly useful for ophthalmic applications and methods for making and using the same. More particularly, the present invention relates to relatively soft, optically transparent, foldable, high refractive index Materials particularly suited for use in the production of intraocular lenses, contact lenses, and other ocular implants and to methods for manufacturing and using the same.

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Номер записи: 4

09-02-2012 дата публикации

Osteoarthritis treatment and device

Номер: US20120035609A1

Автор: Charles F. Leinberry, Peter F. Sharkey

Принадлежит: Knee Creations LLC

A method for treating arthritis of a joint includes identifying a bone lesion in a bone adjacent to the joint; and implanting in the bone a reinforcing member in or adjacent to the bone lesion. A kit for conducting the method includes: (a) at least one reinforcing member having a proximal face adapted to face the joint, a distal face adapted to face away from the joint, and a wedge-shaped edge adapted to pierce bone, wherein the at least one reinforcing member is planar and sterile; and (b) a container adapted to maintain the at least one reinforcing member sterile. Another kit includes: (a) a sterile fluid; (b) a syringe for injecting the fluid into a bone; (c) a curing agent adapted to cure the fluid to polymerize and/or cross-link; and (d) a container adapted to maintain the sterility of contents of the container.

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Номер записи: 5

16-02-2012 дата публикации

Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use

Номер: US20120039980A1

Автор: David M. Gravett, George Y. Daniloff, Jacqueline Schroeder, Louis C. Sehl, Olof Mikael Trollsas, Philip M. Toleikis

Принадлежит: AngioDevice International GmbH

Methods of preventing adhesion between issues are provided that utilizes in situ crosslinked biomaterials. The biomaterial contains at least the crosslinked product of two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Exemplary uses for the crosslinked compositions include preventing adhesions following surgery or injury, and preventing scar tissue formation.

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Номер записи: 6

23-02-2012 дата публикации

Devices and methods for treating defects in the tissue of a living being

Номер: US20120046758A1

Автор: Douglas G. Evans, Russell T. Kronengold, Scott M. Goldman

Принадлежит: Evans Douglas G, Goldman Scott M, Kronengold Russell T

An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery.

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Номер записи: 7

19-04-2012 дата публикации

Implantable liposome embedded matrix composition, uses thereof, and polycaprolactone particles as scaffolds for tissue regeneration

Номер: US20120093914A1

Автор: Shai Yehoshua Schubert

Принадлежит: MOMA THERAPEUTICS

In various embodiments, the present invention describes materials and methods for the local reprogramming of cells in a location where the treatment is applied. The invention can be used to replace lost cells or to restore function to tissue damaged due to disease, injury or genetic defect. In various embodiments, the treatment includes a semisolid hydrogel embedded with liposomes. The liposomes can contain an effector molecule or molecules. When phagocytic cells such as monocytes infiltrate the hydrogel, they encounter the liposomes and incorporate the liposomes carrying the effector molecules into the cells. In some embodiments, the effector molecules can be genetic material encoding the expression of specific proteins such as transcription factors, the expression of which can initiate the reprogramming of the cells. In other embodiments, the effector molecules can induce angiogenesis. In other embodiments, the effector molecules are tumor antigens. The matrix can contain other effector molecules designed to attract specific cells to the matrix. The cells can be released from the matrix as the matrix degrades or by active migration from the matrix. The cells can also remain in the matrix and secret molecules such as proteins and hormones that will diffuse through the matrix material to the surrounding tissue.

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Номер записи: 8

26-04-2012 дата публикации

Osteoinductive bone graft injectable cement

Номер: US20120100225A1

Автор: William F. Mckay

Принадлежит: WARSAW ORTHOPEDIC INC

Osteoconductive bone graft materials are provided. These compositions contain injectable cements and demineralized bone matrix fibers. The combination of these materials enables the filling of a bone void while balancing strength and resorption.

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Номер записи: 9

03-05-2012 дата публикации

Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same

Номер: US20120107383A1

Автор: William F. Mckay

Принадлежит: WARSAW ORTHOPEDIC INC

Osteoconductive matrices and methods are provided that have one or more statins disposed in calcium phosphate particles. The matrices may be injected into a fracture site. The osteoconductive matrices provided allow for sustained release of the statin and facilitate bone formation and repair of the fracture site.

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Номер записи: 10

10-05-2012 дата публикации

Joint device and method

Номер: US20120116523A1

Автор: Peter Forsell

Принадлежит: MILUX HOLDING SA

A mould adapted to be introduced into a joint of a human patient for resurfacing at least one carrying contacting surface of said joint is provided. The mould is adapted to receive material for resurfacing at least one carrying contacting surface of said joint. The mould is further adapted to be resorbed by the human body or melt after having served its purpose. Further, a method of treating hip joint osteoarthritis in a human patient by providing an artificial hip joint surface using a mould is provided. The method comprises the steps of: said mould being placed inside of said hip joint, said mould being injected with a fluid adapted to harden, said fluid hardening inside of said hip joint, said mould being resorbed by the human body, and said hardened fluid serving as artificial hip joint surface.

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Номер записи: 11

17-05-2012 дата публикации

Multiamino Acid-Based Poly(Ester Amide)s

Номер: US20120123064A1

Автор: Chih-Chang Chu, Mingxiao Deng

Принадлежит: CORNELL UNIVERSITY

Biodegradable saturated and unsaturated polyester amides (PEA)s made from multiamino acid monomers and methods of making biodegradable saturated and unsaturated PEAs.

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Номер записи: 12

24-05-2012 дата публикации

Preparation of bone cement compositions

Номер: US20120129761A1

Автор: Eva Liden, Jeffrey C. Karr, Malin Nilsson, Veronica Sandell

Принадлежит: Bone Support AB

A method for the preparation of injectable ready-to-use paste bone cement compositions by mixing a dry inorganic bone cement powder comprising a particulate calcium sulfate hemihydrate capable of hardening in vivo by hydration of the calcium sulfate hemihydrate forming calcium sulfate dihydrate, an aqueous liquid and an additive that normally retards the setting process, said method comprising a) providing a bone cement powder comprising calcium sulfate hemihydrate, an accelerator for the hardening of the calcium sulfate hemihydrate by hydration, said accelerator being selected from the group consisting of saline and calcium sulfate dihydrate, and a powdered calcium phosphate component b) mixing the bone cement powder with the aqueous liquid for a period of time c) leaving the mixture for the time needed for allowing the hydration reaction of the calcium sulfate hemihydrate to proceed and allowing calcium sulfate dihydrate crystals to form and grow, and d) admixing the additive by means of a short-duration mixing using a minimum of energy surprisingly shortens the setting times for the cement comprising the additive that retard the setting process to the level observed in the absence of the additive and enables a complete hydration of calcium sulfate hemihydrate to calcium sulfate dihydrate, even when using additives else preventing the hardening.

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Номер записи: 13

24-05-2012 дата публикации

Poly(Ester Amide)s and Poly(Ester Ether Amide)s With Pendant Crosslinkable Functional Groups

Номер: US20120130020A1

Автор: Chih-Chang Chu, Xuan Pang

Принадлежит: CORNELL UNIVERSITY

Amino-acid based poly(ester amide) (PEA) or poly(ester ether amide) (PEEA) polymers having pendant cross-linkable functional groups. The polymers can be cross-linked to form a hydrogel. These polymers can be used in biomedical applications.

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Номер записи: 14

31-05-2012 дата публикации

Phosphorylcholine-based amphiphilic silicones for medical applications

Номер: US20120136087A1

Автор: Ananth V. Iyer, Anfeng Wang, James Parakka, Robert Ward, Xuwei Jiang, Yuan Tian

Принадлежит: DSM IP ASSETS BV

Amphiphilic biomimetic phosphorylcholine-containing silicone compounds for use in both topical and internal applications as components in biomedical devices. The silicone compounds, which include zwitterionic phosphorylcholine groups, may be polymerizable or non-polymerizable. Specific examples of applications include use as active functional components in ophthalmic lenses, ophthalmic lens care solutions, liquid bandages, wound dressings, and lubricious and anti-thrombogenic coatings.

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Номер записи: 15

21-06-2012 дата публикации

Bone substitute material

Номер: US20120157291A1

Автор: Anthony William Miles, Irene Gladys Turner, Paul Gittings Jonathan

Принадлежит: Mesuro Ltd

A method of fabricating a bone substitute material comprises the steps of providing a foam material ( 3 ) having an open cell structure, distorting the shape of the foam material ( 3 ) and holding the material in a distorted shape, coating the walls of the cells of the foam material with a ceramic slip ( 5 ), removing the foam material, and sintering the ceramic slip to form a bone substitute material that is approximately a positive image of the distorted foam material ( 3 ). In another method, a granular bone material is formed from a multiplicity of pieces of foam that are not distorted.

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Номер записи: 16

21-06-2012 дата публикации

Surgical Implant

Номер: US20120158136A1

Автор: Adrian Baumgartner, Christian Brunner, Cyril Voisard

Принадлежит: Synthes USA LLC

A surgical implant comprises a body having a compressed state and an uncompressed state. An envelope contains the body in at least the compressed state. The envelope forms an air-tight seal around the body in the compressed state and is water-soluble or degradable in body fluids.

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Номер записи: 17

28-06-2012 дата публикации

Uveoscleral drug delivery implant and methods for implanting the same

Номер: US20120165933A1

Автор: David Haffner, Kenneth Curry

Принадлежит: Dose Medical Corp

Devices and methods for treating intraocular pressure are disclosed. The devices include drug delivery implants for treating ocular tissue. Optionally, the devices also include shunts for draining aqueous humor from the anterior chamber to the uveoscleral outflow pathway, including the supraciliary space and the suprachoroidal space. The drug delivery implants can be implanted in ab interno or ab externo procedures.

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Номер записи: 18

28-06-2012 дата публикации

Nonwoven tissue scaffold

Номер: US20120165939A1

Автор: Joseph J. Hammer, Mark Timmer, Shetty Dhanuraj, Sridevi Dhanaraj, Stephanie M. Kladakis

Принадлежит: DePuy Mitek LLC

A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.

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Номер записи: 19

05-07-2012 дата публикации

Cell-guiding fibroinductive and angiogenic scaffolds for periodontal tissue engineering

Номер: US20120171257A1

Автор: Bülend Inanç, Levent Inanç

Принадлежит: Individual

Disclosed are methods for producing cell-guiding fibroinductive and angiogenic tissue engineering scaffolds composed of biodegradable and biocompatible natural biopolymers, synthetic polymers and/or their combination, incorporating growth and differentiation factors, growth hormone and chemoattractants, with interconnected pores and channels-containing microarchitecture inducing the regenerative cell migration, adhesion, proliferation and differentiation from the healthy tissues surrounding the periodontal defects, thereby facilitating the functional periodontal tissue regeneration. The methods for the application of the cell-guiding fibroinductive and angiogenic scaffolds in the surgical treatment of periodontal tissue defects resulted from destructive periodontal diseases are also provided.

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Номер записи: 20

05-07-2012 дата публикации

Bone prosthetic material

Номер: US20120172998A1

Автор: Makoto Oishi

Принадлежит: Olympus Terumo Biomaterials Corp

Disclosed is a bone prosthetic material that is capable of preventing a plurality of members from being disconnected due to a difference in the coefficient of thermal expansion, and that is also capable of facilitating the work to insert them while ensuring the bone replacement capability. Provided is a bone prosthetic material comprising: a plurality of prosthetic material pieces and which include bioabsorbable materials having different absorption rates, and which are adjacent and connected to each other; and a joint which is provided in a connecting surface between these prosthetic material pieces and, and which is mutually combined to connect the prosthetic material pieces and while limiting displacement in directions along the connecting surface.

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Номер записи: 21

19-07-2012 дата публикации

Low viscosity liquid polymeric delivery system

Номер: US20120183629A1

Автор: Richard L. Dunn

Принадлежит: DUNN RES AND CONSULTING LLC

Low viscosity biodegradable polymer solutions of a liquid biodegradable polymer and biocompatible solvent and methods of using the compositions to form a biodegradable liquid polymer implant are provided.

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Номер записи: 22

19-07-2012 дата публикации

Polymer coating comprising 2- methoxyethyl acrylate units synthesized by surface-initiated atom transfer radical polymerization

Номер: US20120184029A1

Автор: Charlotte Juel, Katja Jankova Atanasova, Søren Hvilsted

Принадлежит: Danmarks Tekniskie Universitet

The present invention relates to preparation of a polymer coating comprising or consisting of polymer chains comprising or consisting of units of 2-methoxyethyl acrylate synthesized by Surface-Initiated Atom Transfer Radical Polymerization (SI ATRP) such as ARGET SI ATRP or AGET SI ATRP and uses of said polymer coating.

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Номер записи: 23

19-07-2012 дата публикации

Supporting and Forming Transitional Material for Use in Supporting Prosthesis Devices, Implants and to Provide Structure in a Human Body

Номер: US20120184974A1

Автор: Hilton Becker

Принадлежит: Individual

A biocompatible fabric comprised of a strong absorbable material and ultra fine permanent fibers which serve as a collagen support system for prosthesis devices and implants. The permanent fibers stimulate the growth of collagen but are too weak to offer the initial support desired. As the absorbable material dissolves, the collagen formed over the permanent fiber assumes the support role from the absorbable material. The supporting system is natural in appearance and motion without encapsulation or rigidity. The absorbable material can be overlaid with the non-absorbable fiber which after absorption leaves the non-absorbable mesh in an array. The fibers can be discontinuous, loosely woven or embedded in an absorbable material and can be patterned to provide various strengths and degrees of motion and movement. The materials can be coated or infused with materials to reduce infection, provide tissue growth, reduce scar tissue or other medicinal purposes.

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Номер записи: 24

26-07-2012 дата публикации

Polyethylene cross-linked with an anthocyanin

Номер: US20120187607A1

Автор: Aiguo Wang, Daniel E. Lawrynowicz, Shi-Shen Yau, Shulin He

Принадлежит: Howmedica Osteonics Corp

A method for manufacturing of ultrahigh molecular weight polyethylene (UHMWPE) for implants, where the implants have been machined out of UHMWPE blocks or extruded rods, has anthocyanin dispersely imbedded in the polyethylene. The implant is then exposed to γ ray or electron beam irradiation in an amount of at least 2.5 Mrad followed by a heat treatment to prevent the implant from becoming brittle in the long term as well as to improve strength and wear. The method includes mixing a powder or granulate resin of UHMWPE with an aqueous liquid that contains anthocyanin in a predetermined amount. The water is evaporated in order to deposit the anthocyanin in a predetermined concentration on the polyethylene particles. The doped UHMWPE particles are compressed into blocks at temperatures in a range of approximately 135° C.-250° C. and pressures in a range of approximately 2-70 MPa. Medical implants are made from the blocks.

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Номер записи: 25

23-08-2012 дата публикации

Composition for promoting wound healing

Номер: US20120213843A1

Автор: Anders Carlsson, Jan Holmback

Принадлежит: LIPIDOR AB

A lipid layer forming wound healing promoting composition comprising volatile silicone oil, polar lipid, C 2 -C 4 aliphatic alcohol, and a wound healing agent, in particular a low to medium size natural or synthetic peptide. Also disclosed is a method of forming the lipid layer on a wound and a medical patch provided with the composition.

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Номер записи: 26

23-08-2012 дата публикации

Process for demineralization of bone matrix with preservation of natural growth factors

Номер: US20120213859A1

Автор: Benjamin P. Luchsinger, Darrel L. Holmes, Gregory A. Juda, Jesus Hernandez, Kelly R. Kirker, Nancy J. Shelby, Steven M. Scott

Принадлежит: Bacterin International Inc

A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.

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Номер записи: 27

30-08-2012 дата публикации

Biodegradable fiber and fiber wadding for filling bone defects and method for producing the same

Номер: US20120219595A1

Автор: Toshihiro Kasuga, Xianfeng Yao, Yoshio Ota

Принадлежит: Nagoya Institute of Technology NUC, Orthorebirth Co Ltd

A fiber wadding formed from a biodegradable polymer fiber containing calcium carbonate fine particles including silicon that is characterized in that hydroxyapatite is precipitated and scattered nearly uniformly on the surface of the biodegradable polymer fiber is disclosed. Further, a method for production of fiber wadding that includes the steps of heating and kneading silicon-containing calcium carbonate fine particles and a biodegradable polymer to produce a composite, dissolving the composite by mixing the composite with a solvent to obtain a spinning solution, processing the spinning solution into fiber wadding by using electrospinning method, and alternatingly immersing the fiber wadding in a calcium aqueous solution and a phosphate aqueous solution to cause precipitation of hydroxyapatite in an approximately uniformly scattered manner on the surface of the fibers is disclosed.

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Номер записи: 28

20-09-2012 дата публикации

Functionalizing implantable devices with a poly (diol citrate) polymer

Номер: US20120237443A1

Автор: Guillermo Ameer, Jian Yang

Принадлежит: Northwestern University

The present invention is directed to a novel poly (diol citrates)-based coating for implantable devices. More specifically, the specification describes methods and compositions for making and using implantable devices coated with citric acid copolymers or citric acid copolymers impregnated with therapeutic compositions and/or cells.

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Номер записи: 29

27-09-2012 дата публикации

Forrest Sponge Aided Sinus Membrane Lift Technique

Номер: US20120244499A1

Автор: Arthur Thomas Forrest

Принадлежит: Individual

The technical considerations of my invention are the use of medical grade polyurethane foam in sinus membrane surgery by a dentist, physician, or a veterinarian, as a non-cutting surgical instrument. The invention is use of various shapes to do the job of cutting loose the sinus membrane from the sinus floor and sinus walls, surgery is made safer and simpler. The scope of the invention is, therefore, indicated by the claims rather than the foregoing description. Furthermore the present invention may be utilized in other specific forms without departing from the spirit or essential characteristics. The forms and shapes and various components are merely exemplary and can be varied and still fall within the scope of the invention. The scope of the invention will be determined only by the claims.

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Номер записи: 30

04-10-2012 дата публикации

System and Method for Formation of Biodegradable Ultra-Porous Hollow Fibers and Use Thereof

Номер: US20120248658A1

Автор: Roland Ostapoff, Seth Gleiman

Принадлежит: COVIDIEN LP

A system and method for forming biodegradable ultra-porous hollow fibers are disclosed. The fibers are formed by electrospinning a liquid polymer composition (e.g., solution) of a high molecular weight aliphatic polyester in a controlled environment.

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Номер записи: 31

18-10-2012 дата публикации

Implantable polymer for bone and vascular lesions

Номер: US20120263797A1

Автор: Andrew J. Carter, Arthur C. Watterson, Craig M. Jones, Jeffrey A. D'Agostino

Принадлежит: BIOS2 Medical Inc

A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymethylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures.

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Номер записи: 32

18-10-2012 дата публикации

Polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer

Номер: US20120264852A1

Автор: Ariane Vartanian, Susan P. James, Susan S. Yonemura

Принадлежит: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

The present invention relates to polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer. The present invention also relates to hydrogels containing the polymeric materials. The present invention further relates to methods of synthesizing the polymeric materials and hydrogels of the present invention.

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Номер записи: 33

25-10-2012 дата публикации

Plug components for bone tunnel

Номер: US20120271414A1

Автор: Osamu Masaki

Принадлежит: MMT Co Ltd

A component for satisfactorily plugging a bone tunnel formed in surgery such as ACL reconstruction by regenerating bone in a space portion of the bone tunnel (e.g., a bone tunnel for an arthroscope), is provided in order to solve the problems in the conventional technologies. The plug component is made of a calcium phosphate-based material, comprises a porous part having a porosity of 50 to 85%, and has a cylindrical shape such that one of its bottom surfaces forms an angle of 30 to 60 degrees to its central axis.

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Номер записи: 34

25-10-2012 дата публикации

Ceramic manufactures

Номер: US20120271429A1

Автор: Gerald J. Jerry, JR., Louis A. Serafin, Jr., Nicholas H. Burlingame

Принадлежит: Xylon LLC

Fired magnesium oxide stabilized transformation toughened zirconia ceramic can be for or of an implant or implant component of a one-piece unicompartmental knee spacer device; a multi-piece unicompartmental joint aligning device; a temporal mandibular joint cap implant; a vertebra cap; an ankle joint ensemble or component; a bridge, a tooth or teeth; a patellofemoral joint implant; a tibial tray for a knee joint replacement implant; an intermediary articulation plate for a tibial tray and liner for a knee joint replacement implant; or the intermediary articulation plate assembled in combination with the tibial tray.

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Номер записи: 35

22-11-2012 дата публикации

Polymer gel formulation

Номер: US20120294827A1

Автор: Abraham J. Domb, Boris Vaisman, Lior Yankelson, Moran Yaniv

Принадлежит: JUVENIS Ltd

A polymer gel, in at least some embodiments, featuring both cross-linked castor oil and branched castor oil components, in which the castor oil is optionally replaced by ricinoleic acid.

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Номер записи: 36

06-12-2012 дата публикации

In-situ intervertebral fusion device and method

Номер: US20120310352A1

Автор: John D. Malone, Thomas M. DiMauro

Принадлежит: DePuy Spine LLC

An orthopedic device for implanting between adjacent vertebrae comprising: an arcuate balloon and a hardenable material within said balloon. In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means.

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Номер записи: 37

13-12-2012 дата публикации

Method and apparatus for diverting sweat, liquid, moisture, or the like from an eye

Номер: US20120312445A1

Автор: Thomas Charles Kuracina, Tim L. Kitchen

Принадлежит: Individual

Moisture diverters attachable to a region above the eye and below the eyebrow that prevents sweat, liquid, moisture, or the like from entering the eyes of a wearer is described. A moisture diverter may include a substrate having an inner surface facing the wearer and an outer surface facing away from the wearer. The inner surface comprises a lower adhesive section and an upper adhesive-free section, the adhesive section releasably attaches the diverter to the wearer at a point above the eye and below the eyebrow, the adhesive-free section shaped or shapeable to abut or protrude from eyebrow region of a wearer and to divert moisture away from the eye.

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Номер записи: 38

27-12-2012 дата публикации

Cell construct comprising polymer blocks having biocompatibility and cells

Номер: US20120329157A1

Автор: Kentaro Nakamura

Принадлежит: Fujifilm Corp

It is an object of the present invention to provide a cell three-dimensional construct that has a thickness sufficient for tissue regeneration and comprises cells uniformly distributed therein. The present invention provides a cell construct comprising polymer blocks having biocompatibility and cells, wherein the plural polymer blocks are arranged in spaces between the plural cells.

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Номер записи: 39

03-01-2013 дата публикации

Polymer nanofiber scaffold for a heparin / fibrin based growth factor delivery system

Номер: US20130004541A1

Автор: Andrea Schwartz, Jingwei Xie, Matthew Silva, Richard Gelberman, Shelly Sakiyama-Elbert, Stavros Thomopoulos, Younan Xia

Принадлежит: Washington University in St Louis WUSTL

A growth factor delivery scaffold combines a heparin/fibrin-based delivery system (HBDS) with a backbone based on polymer nanofibers for tissue (e.g., tendon and ligament) repair. The scaffold has improved surgical handling properties compared to the gelatinous consistency of the prior art HBDS system and retains the capability for delivering mesenchymal cells and controlling the release of growth factors. One application for the scaffold is mesenchymal stem cell (MSC) therapy for flexor tendon repair. The scaffold can deliver growth factors in a sustained manner, can be implanted for flexor tendon repair, is biocompatible, and is not cytotoxic. The growth factor delivery scaffold may also be used in the surgical repair of an injury to bone, muscle, cartilage, or other tissues.

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Номер записи: 40

03-01-2013 дата публикации

Cell support and bone regeneration material

Номер: US20130004549A1

Автор: Kentaro Nakamura, Masaki Nakamura

Принадлежит: Fujifilm Corp

An object of the present invention is to provide a three-dimensional cell support that is capable of uniformly distributing cells and retaining the cells in a state without nonuniformity and is made of a biodegradable material. The present invention provides a cell support consisting of a porous body made of a biodegradable material, the porous body having the following properties: (a) a porosity from 81% to 99.99%, (b) an average pore size of 10 to 400 μm, (c) having a hole interconnecting pores, and (d) a water absorption rate from 1000% to 9900%.

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Номер записи: 41

17-01-2013 дата публикации

Tricalcium Phosphate Coarse Particle Compositions and Methods for Making the Same

Номер: US20130017233A1

Автор: David C. Delaney, Duran N. Yetkinler, Sahil Jalota

Принадлежит: Skeletal Kinetics LLC

Methods for preparing a tricalcium phosphate coarse particle composition are provided. Aspects of the methods include converting an initial tricalcium phosphate particulate composition to hydroxyapatite, sintering the resultant hydroxyapatite to produce a second tricalcium phosphate composition and then mechanically manipulating the second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition. The subject methods and compositions produced thereby find use in a variety of applications.

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Номер записи: 42

24-01-2013 дата публикации

Porous materials, methods of making and uses

Номер: US20130023987A1

Автор: Alexei Goraltchouk, Dimitrios Stroumpoulis, Futian Liu, Nicholas J. Manesis

Принадлежит: Allergan Inc

The present specification discloses porous materials, methods of forming such porous materials, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

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Номер записи: 43

31-01-2013 дата публикации

Kit and method for producing bone cement

Номер: US20130030058A1

Автор: Hubert Büchner, Sebastian Vogt

Принадлежит: HERAEUS MEDICAL GMBH

A kit for producing bone cement includes at least one paste A and one paste B. Paste A contains at least one monomer (a1) for radical polymerization; at least one polymer (a2) insoluble in monomer (a1); at least one polymer (a3) soluble in monomer (a1); and at least one radical polymerization initiator (a4). The weight ratio of the at least one polymer (a2) to the at least one polymer (a3) is at least 2 to 1. Paste B contains at least one monomer (b1) for radical polymerization; at least one polymer (b2) and at least one accelerator (b3) soluble in monomer (b1); and optionally a polymer (b4) insoluble in monomer (b 1 ). The maximum quantity of polymer (b4) is 5% by weight, relative to the total weight of paste B. The weight ratio of polymer (b4) to the at least one polymer (b2) is no more than 0.2.

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Номер записи: 44

31-01-2013 дата публикации

Resilient knee implant and methods

Номер: US20130030542A1

Автор: R. Thomas Grotz

Принадлежит: Grotz R Thomas

This disclosure is directed to a resilient interpositional arthroplasty implant for application into a knee joint to pad cartilage defects, cushion a joint, and replace or restore the articular surface, which may preserve joint integrity, reduce pain and improve function. The implant may endure variable joint compressive and shear forces and cyclic loads. The implant may repair, reconstruct, and regenerate joint anatomy, and thereby improve upon joint replacement alternatives. Rather than using periosteal harvesting for cell containment in joint resurfacing, the walls of this invention may capture, distribute and hold living cells until aggregation and hyaline cartilage regrowth occurs. The implant may be deployed into debrided joint spaces, molding and conforming to surrounding structures with sufficient stability to avoid extrusion or dislocation. Appendages of the implant may repair or reconstruct tendons or ligaments, and an interior of the implant that is inflatable may accommodate motions which mimic or approximate normal joint motion.

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Номер записи: 45

14-02-2013 дата публикации

Silk-Based Ionomeric Compositions

Номер: US20130039986A1

Автор: David L. Kaplan, Monica A. Serban

Принадлежит: TUFTS UNIVERSITY

Disclosed herein are pH-dependent silk fibroin-based ionomeric compositions and colloids, and methods of making the same. The state of the silk fibroin ionomeric compositions is reversible and can transform from a gel-like colloid to a more fluid-like solution, or vice versa, upon an environmental stimulus, e.g., pH. Thus, the silk-based ionomeric compositions and colloids can be applied in various industries, ranging from electronic applications to biomedical applications, such as sensors, gel diodes, absorbent materials, drug delivery systems, tissue implants and contrast agents.

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Номер записи: 46

14-02-2013 дата публикации

Injectable, load-bearing cell/microbead/calcium phosphate bone paste for bone tissue engineering

Номер: US20130039990A1

Автор: Huakun Xu, Michael Weir

Принадлежит: University of Maryland at Baltimore

The invention provides injectable, stem cell-containing calcium phosphate bone pastes for bone tissue engineering and methods of making and using the same.

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Номер записи: 47

21-02-2013 дата публикации

Polysaccharide Based Hydrogels

Номер: US20130045182A1

Автор: Glen Gong, Scott Robert Sershen, Suresh Subraya Pai

Принадлежит: Individual

Polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and systems for use in preparing the subject compositions.

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Номер записи: 48

21-02-2013 дата публикации

Sequentially cross-linked polyethylene

Номер: US20130046042A1

Автор: Aaron Essner, Aiguo Wang, John H. Dumbleton, Shi-Shen Yau

Принадлежит: Howmedica Osteonics Corp

A method of producing an improved polyethylene, especially an ultra-high molecular weight polyethylene utilizes a sequential irradiation and annealing process to form a highly cross-linked polyethylene material. The use of sequential irradiation followed by sequential annealing after each irradiation allows each dose of irradiation in the series of doses to be relatively low while achieving a total dose which is sufficiently high to cross-link the material. The process may either be applied to a preformed material such as a rod or bar or sheet made from polyethylene resin or may be applied to a finished polyethylene part.

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Номер записи: 49

14-03-2013 дата публикации

Multicomponent and biocompatible nanocomposite materials, methods of synthesizing same and applications of same

Номер: US20130064863A1

Автор: Alexandru R. Biris, Alexandru S. Biris

Принадлежит: University of Arkansas

One aspect of the present invention relates to a method of synthesizing a multicomponent and biocompatible nanocomposite material, which includes: synthesizing a gold/hydroxyapatite (Au/HA) catalyst; distributing the Au/HA catalyst into a thin film; and heating the thin film in a reactor with a carbon source gas to perform radio frequency chemical vapor deposition (RF-CVD) to form the nanocomposite material, where the nanocomposite material includes a graphene structure and Au/HA nanoparticles formed by the Au/HA catalyst and distributed within the graphene structure. In another aspect, a multicomponent and biocompatible nanocomposite material includes: a graphene structure formed with a plurality of graphene layers and Au/HA nanoparticles distributed within the graphene structure. The nanocomposite material is formed by heating an Au/HA catalyst thin film with a carbon source gas to perform radio frequency chemical vapor deposition (RF-CVD).

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Номер записи: 50

14-03-2013 дата публикации

Synthetic scaffolds and organ and tissue transplantation

Номер: US20130066438A1

Автор: Alexander M. Seifalian

Принадлежит: Individual

Articles, compositions, and methods for growing tissues and organs using bioreactors, including rotating bioreactors, are provided. Synthetic scaffolds for growing artificial tissue and organ transplants are also provided.

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Номер записи: 51

21-03-2013 дата публикации

Conformable Therapeutic Shield for Vision and Pain

Номер: US20130070200A1

Автор: Ashley Tuan, Brian Levy, Cary J. Reich, Dean Carson, Doug Rimer, Douglas Sutton, Enrique Barragan, Eugene de Juan, Jr., K. Angela Macfarlane, Matt Clarke, Yair Alster

Принадлежит: Nexis Vision Inc

A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

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Номер записи: 52

21-03-2013 дата публикации

COMPOSITION COMPRISING PHOSPHONIC ACID POLYMER FOR USE AS TISSUE ENGINEERING FIBROUS SCAFFOLD

Номер: US20130071464A1

Автор: Bassi Anita Kaur, Downes Sandra, Gough Julie Elizabeth, Zakikhani Moshen

Принадлежит: THE UNIVERSITY OF MANCHESTER

A fibrous tissue scaffold wherein fibres of the scaffold comprise a phosphonic acid polymer. The fibres preferably incorporate a vinylphosphonic acid—acrylic acid copolymer, and may further include polycaprolactone. There is further described medical implant coating comprising a phosphonic acid polymer, a biocompatible fibre comprising a phosphonic acid polymer and a biocompatible polymer comprising polycaprolactone and a phosphonic acid polymer. 136-. (canceled)37. A medical implant coating comprising a phosphonic acid polymer.38. A coating according to claim 37 , wherein said phosphonic acid polymer comprises at least one phosphono or phosphino moiety.39. A coating according to claim 37 , wherein said phosphonic acid polymer is a phosphonic acid homopolymer claim 37 , or a phosphonic acid heteropolymer incorporating one or more other types of polymer.40. A coating according to claim 37 , wherein said phosphonic acid polymer is a phosphonic acid homopolymer selected from the group consisting of vinyl phosphonic acid claim 37 , vinylidene-1 claim 37 ,1-diphosphonic acid claim 37 , phosphono-substituted mono-carboxylic acid claim 37 , phosphono-substituted di-carboxylic acid claim 37 , hypophosphorus acid claim 37 , a hypophosphorus acid salt claim 37 , and phosphono-succinic acid.41. A coating according to claim 37 , wherein said phosphonic acid polymer is a phosphonic acid heteropolymer of phosphonic acid and one or more further monomers selected from the group consisting of carboxylic acid claim 37 , sulphonic acid claim 37 , amides claim 37 , amines claim 37 , polyalkylene imines claim 37 , and amine-terminated polyalkylene glycols.42. A coating according to wherein said phosphonic acid polymer is a phosphonic acid heteropolymer selected from the group consisting of vinylphosphonic acid and vinylsulphonic acid claim 37 , vinylphosphonic acid and acrylic acid claim 37 , vinylphosphonic acid and methacrylic acid claim 37 , vinylphosphonic acid and acrylamide claim ...

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Номер записи: 53

21-03-2013 дата публикации

Device and method for treating central nervous system pathology

Номер: US20130072827A1

Автор: David L. Carroll, Jie Liu, Louis C. Argenta, Michael J. Morykwas, Nicole H. Levi, Stephen Tatter, William D. Wagner

Принадлежит: Wake Forest University Health Sciences

The present invention relates generally to a device and method for treating tissues of the central nervous system and more particularly, but not exclusively, to a device and method for treating the brain tissue.

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Номер записи: 54

21-03-2013 дата публикации

Medical Implants With Increased Hydrophilicity

Номер: US20130073042A1

Автор: Derrick W. Johns, Gary Ghiselli, Jami Hafiz, Joseph Crudden, Peter Whang

Принадлежит: Difusion Technologies Inc

Devices such as orthopedic implants are composed of a thermoplastic resin such as polyaryletheretherketone (PEEK), and include a ceramic species, such as a zeolite, to enhance its hydrophilic properties. The ceramic species can be a surface coating, can be incorporated or embedded into the thermoplastic resin, or can be both a surface coating and incorporated or embedded into the resin. In certain embodiments, the ceramic species is zeolite that is incorporated into the device, especially at the exposed surface of the device, and is devoid of antimicrobial metal ions. The device is introduced into the body surgically.

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Номер записи: 55

28-03-2013 дата публикации

Polyisobutylene-based polyurethanes

Номер: US20130079487A1

Автор: Rudolf Faust, Umaprasana Ojha

Принадлежит: Individual

An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.

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Номер записи: 56

11-04-2013 дата публикации

IMPLANTABLE EMBOLIC SCAFFOLDS THAT PROMOTE HEALING

Номер: US20130089576A1

Автор: Maitland Duncan J., Wilson Thomas S.

Принадлежит:

Implant devices and structures that reduce inflammation and promote healing of the area of implant. Specifically, the use of shape memory open cell biocompatible polymer foams for implants that assist in and promote healing and especially in filling and sealing aneurisms. 1. A method of reducing inflammation and promoting healing in vascular embolic applications comprising implantation of an open cell polymer foam scaffold in a vascular abnormality to promote blood clotting and growth of extracellular matrix throughout the scaffold.2. The method of wherein the open cell polymer foam scaffold have cell sized from 50 nm to 5 mm and have at least 20% of membranes between cells removed.3. The method of wherein the open cell polymer scaffold have at least 50% of membranes between cells removed.4. The method of wherein the polymer is selected from the group consisting of polyurethanes claim 1 , polyacrylates claim 1 , polymethacrylates claim 1 , polyolefins claim 1 , polyorganosiloxanes claim 1 , polyesters claim 1 , polyethers claim 1 , and copolymers of polymers.5. The method of wherein the open cell polymer foam is made from monomers of N claim 1 ,N claim 1 ,N′ claim 1 ,N′-145 Tetrakis (2-hydroxypropyl) ethylenediamine (HPED) claim 1 , 2 claim 1 ,2′ claim 1 ,2″-Nitrilotriethanol (TEA) and 1 claim 1 ,6 Diisocyanatohexane (HDI) and either chemical and physical blowing agents or both.6. The method of wherein the open cell polymer foam is biocompatible.7. The method of wherein the vascular abnormality is a cranial aneurism or septal opening.8. A composition for use in implantable devices that reduce inflammation and promote healing comprising an open cell shape memory polymer foam with cells sized from 50 nm to 5 mm and have at least 20% of membranes between cells removed.9. The composition of wherein the open cell polymer scaffold have at least 50% of membranes between cells removed.10. The composition of wherein the polymer is selected from the group consisting of ...

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Номер записи: 57

11-04-2013 дата публикации

ALLOPLASTIC INJECTABLE DERMAL FILLER AND METHODS OF USE THEREOF

Номер: US20130089580A1

Автор: Boutros Ayman

Принадлежит:

A composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent is provided. A method of making a composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent, said method comprising admixing a biocompatible and pliable material with a physiologically acceptable suspending agent, is also provided. A method of augmenting soft tissue to provide long-term reduction of a skin defect, said method comprising stimulating collagen beneath the skin defect is further provided. In an embodiment of the method of augmenting soft tissue, the stimulation of collagen production is effected by injecting into the deep reticular dermis an a dermal filler, said dermal filler being an alloplastic injectable suspension and comprising a biocompatible and pliable material and a physiologically acceptable suspending agent. 1. A composition comprising: an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent; wherein the biocompatible and pliable material is a copolymer of phenylethyl acrylate and phenylethyl methacrylate.2. The composition of claim 1 , wherein the acrylate/methacrylate copolymer is a solid.3. The composition of claim 2 , wherein the solid selected from the group consisting of: a powder claim 2 , a non-porous microbead claim 2 , and a microsphere.4. The composition of claim 2 , wherein the solid comprises particles each having a diameter selected from the group consisting of: about 10μ to about 100μ; about 0.01μ to about 10μ claim 2 , and about 0.01μ to about 5μ.5. The composition of claim 1 , wherein the physiologically acceptable suspending agent is resorbable.6. The composition of claim 5 , wherein the physiologically ...

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Номер записи: 58

11-04-2013 дата публикации

MACROPOROUS BIOENGINEERED SCAFFOLDS FOR CELL TRANSPLANTATION

Номер: US20130089594A1

Автор: Anderson Cheryl Stabler, Buchwald Peter, Fraker Christopher A., Hubbell Jeffrey, Inverardi Luca, Kenyon Norma Sue, Latta Paul, Pedraza Eileen, Pileggi Antonello, Ricordi Camillo D., Weaver Jessica

Принадлежит:

The present invention provides highly porous, biocompatible and biostable scaffold constructs for improving overall cell engraftment, survival, function and long-term viability. These scaffolds can provide mechanical protection to implanted cells, afford retrievability from a subject, and allow for both intra-device vascularization and a means to spatially distribute the cells within the device. The scaffold surface or material may be modified with one or more different adhesion proteins and optionally other biological factors for enhanced cell adherence and viability. Further, the scaffold surface or material may be modified with one or more agents with slow/sustained release characteristics to aid engraftment, survival, function or long-term viability. Implanted cells of the invention may be insulin-producing cells such as islets. 142-. (canceled)43. An implantable scaffold construct comprising a macroporous scaffold for providing structural support and spatial distribution to implanted cells.44. The scaffold construct of claim 43 , wherein said cells are insulin-producing cells.45. The scaffold construct of claim 43 , wherein said scaffold is fabricated from organosilicone.46. The scaffold construct of claim 43 , wherein said scaffold has at least one property selected from:a) a porosity of 70-95%; andb) pore sizes of 75-400 μm.47. The scaffold construct of claim 43 , wherein the cells comprise mesenchymal stem cells.48. The scaffold construct of claim 43 , wherein said scaffold construct comprises an agent that aids in a property selected from the group consisting of:a) engraftment of the cells implanted in the scaffold;b) survival of the cells implanted in the scaffold;c) function of the cells implanted in the scaffold; andd) long-term viability of the cells implanted in the scaffold.49. The scaffold construct of claim 48 , wherein said agent is selected from the group consisting of:a) an adhesion protein;b) a growth factor;c) an oxygen generating agent;d) an ...

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Номер записи: 59

18-04-2013 дата публикации

Ultraviolet light absorbing materials for intraocular lens and uses thereof

Номер: US20130096273A1

Автор: Adam REBOUL, Patrick H. Benz

Принадлежит: Benz Research and Development Corp

A method for reducing the transmittance of ultraviolet radiation through an intraocular lens to 10% or less at 370 mm Additionally, a method for preventing the transmittance of at least 90% of ultraviolet radiation at 370 nm through a foldable intraocular lens comprising: (a) incorporating a monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety into at least one polymer and (b) forming the polymer into a material suitable for use as an intraocular lens, wherein the monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety comprises 0.10 to 0.15 weight percent of the overall dry polymer.

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Номер записи: 60

25-04-2013 дата публикации

THERMORESPONSIVE COMPOSITIONS FOR DERMATOLOGICAL USE AND METHODS THEREOF

Номер: US20130101547A1

Автор: Olejnik Orest, Whitcup Scott

Принадлежит: ALLERGAN, INC.

The present specification generally relates to compositions comprising a thermoresponsive polymer and methods of treating a soft tissue condition using such compositions. 1. A liquid composition comprising a biocompatible thermoresponsive polymer , wherein the thermoresponsive polymer has a sol-gel phase transition of between about 27° C. to about 35° C. , and wherein the liquid composition does not include a therapeutic agent.2. The composition of claim 1 , wherein the biocompatible thermoresponsive polymer is a PNA-based thermoresponsive polymer.3. The composition of claim 1 , wherein the thermoresponsive polymer is a PVCL-based thermoresponsive polymer claim 1 , a PMVE-based thermoresponsive polymer claim 1 , a PEOVE-based thermoresponsive polymer claim 1 , a PNVIBAm-based thermoresponsive polymer claim 1 , a PNVBAm-based thermoresponsive polymer claim 1 , or a PVEE-based thermoresponsive polymer.4. The composition of claim 1 , wherein the thermoresponsive polymer is a PEO/PPO-based thermoresponsive polymer.5. The composition of claim 4 , wherein the PEO/PPO-based thermoresponsive polymer is a PEO/PPO-based homopolymer claim 4 , a PEO/PPO-based copolymer claim 4 , a PEO/PPO-based block copolymer or a PEO/PPO-based interpenetrating network copolymer.6. The composition of claim 1 , wherein the thermoresponsive polymer is a PEG-based thermoresponsive polymer.7. The composition of claim 1 , wherein the PEG-based thermoresponsive polymer is a PEG-based homopolymer claim 1 , a PEG-based copolymer claim 1 , a PEG-based block copolymer or a PEG-based interpenetrating network copolymer.8. The composition of claim 6 , wherein the PEG-based thermoresponsive polymer is a PEG/polyester-based thermoresponsive polymer.9. The composition of claim 1 , wherein the liquid composition further comprises an anesthetic agent.10. A method of treating a soft tissue or skin condition in an individual in need thereof claim 1 , the method comprising the step of administering a liquid ...

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Номер записи: 61

25-04-2013 дата публикации

Coating of endoprostheses with a coating consisting of a tight mesh of polymer fibers

Номер: US20130103139A1

Автор: Erika Hoffmann, Lutz Freitag, Michael Hoffmann, Roland Horres

Принадлежит: HEMOTEQ AG

The present invention relates to grid-like or net-like endoprosthesis having a continuous, respectively ongoing and interstices-spanning coating with a thread-tangle, wherein this continuous, respectively ongoing and interstices-spanning coating covers the struts as well as the interstices between the single endoprosthesis struts.

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Номер записи: 62

02-05-2013 дата публикации

Refractive-diffractive ophthalmic device and compositions useful for producing same

Номер: US20130107201A1

Автор: Abhijit Bhagvat Patil, Munavvar Tahir Hussain, Sanjay Ram Swaroop Argal, Vinod Chintamani Malshe

Принадлежит: POLYMER TECHNOLOGIES INTERNATIONAL (EOU)

A multifocal ophthalmic device is disclosed, wherein the lens body comprises a curcuminoid compound as a UV-light stabilizer, and/or a co-polymeric composition which is derived from a pre-polymerization mixture of defined monomers The lens body of the multifocal ophthalmic device is being formed with a plurality of concentric annular zones, which effect both diffraction and refraction of incident light, and which are separated by slanted steps that are substantially devoid of any diffractive or refractive power.

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Номер записи: 63

02-05-2013 дата публикации

Hard-tissue implant

Номер: US20130110255A1

Автор: Dawn Thompson, George J. Picha

Принадлежит: Individual

Hard-tissue implants are provided that include a bulk implant, a face, pillars, and slots. The pillars are for implantation into a hard tissue. The slots are to be occupied by the hard tissue. The hard-tissue implant has a Young's modulus of elasticity of at least 10 GPa, has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1, does not comprise any part that is hollow, and does not comprise any non-pillar part extending to or beyond the distal ends of any of the pillars. Methods of making and using hard-tissue implants are also provided.

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Номер записи: 64

16-05-2013 дата публикации

BIODEGRADABLE POLYURETHANE/UREA COMPOSITIONS

Номер: US20130121969A1

Автор: Adhikari Raju, Gunatillake Pathiraja Arachchillage

Принадлежит: POLYNOVO BIOMATERIALS PTY LIMITED

The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention. 1. A biodegradable , biocompatible polyurethane/urea polymer composition comprising the reaction product of: i) one or more isocyanates; and', 'ii) one or more multifunctional core molecules having a molecular weight of 400 or less and at least two functional groups that react with said isocyanate thereby forming urethane or urea groups; and, 'a) a flowable prepolymer comprising the reaction product of i) linear oligomers;', 'ii) star oligomers;', 'iii) dendrimeric oligomers; and', 'iv) hyperbranched oligomers;, 'b) one or more soft segment-forming functional oligomers chosen fromwherein the functional oligomer has degradable arms and is selected from the group consisting of lactides, glycolides, lactide/glycolides, caprolactones, propylene fumarates, glycolic acid, dioxanones, anhydrides and polyorthoesters;wherein the flowable prepolymer is curable with the functional oligomer at 30° C.; andwherein the polymer composition comprises one or more bioactive moieties.2. The biodegradable claim 1 , biocompatible polyurethane/urea polymer composition according to wherein the one or more bioactive moieties is chemically bonded to the composition.3. The biodegradable claim 1 , biocompatible polyurethane/urea polymer composition ...

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Номер записи: 65

16-05-2013 дата публикации

Organophosphorous, Multivalent Metal Compounds, and Bioactive Glass Material Macromolecular Network Compositions and Methods

Номер: US20130122057A1

Автор: Garigapati Venkat R., Kimsey Cassandra L., Murphy Matthew E.

Принадлежит:

Cements containing certain small molecule amino acid phosphate compounds such as phosphoserine and certain multivalent metal compounds such as but not limited to calcium phosphate have been found to have improved properties and form a macromolecular network in the presence of a bioactive glass material that contain silicates, phosphates, and calcium salts which can be involved in the formation of bonding sites. 1. A bone restorative composition comprising a reactive mixture of a small amino acid phosphate species , a multivalent metal compound , and a bioactive glass material that contains ionic functional groups.3. The bone restorative composition of claim 1 , wherein the small amino acid phosphate species is present in an amount from about 10% to about 90% by weight claim 1 , preferably about 15% to about 50% by weight claim 1 , and more preferably about 20% to about 40% by weight claim 1 , based on the combined weight of the compound claim 1 , the multivalent metal compound claim 1 , and the bioactive glass material.4. The bone restorative composition of claim 1 , wherein the small amino acid phosphate species is phosphoserine.5. The bone restorative composition of claim 1 , wherein the multivalent metal compound is present in an amount from about 5% to about 90% by weight claim 1 , preferably about 40% to about 80% by weight claim 1 , and more preferably about 40% to about 65% by weight claim 1 , based on the combined weight of the small amino acid phosphate species claim 1 , the multivalent metal compound claim 1 , and the bioactive glass material.6. The bone restorative composition of claim 1 , wherein the multivalent metal compound is selected from the group consisting of tetracalcium phosphate claim 1 , calcium oxide claim 1 , calcium chloride claim 1 , or calcium hydroxide.7. The bone restorative composition of claim 1 , wherein multivalent metal compound has a mean particle size of greater than 15 μm claim 1 , preferably greater than 25 μm.8. The bone ...

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Номер записи: 66

23-05-2013 дата публикации

INTRINSICALLY MAGNETIC HYDROXYAPATITE

Номер: US20130129634A1

Автор: Banobre Lopez Manuel, LANDI Elena, Marcacci Maurilio, Pressato Daniele, Rivas Rey Jose, SANDRI Monica, TAMPIERI Anna

Принадлежит:

The present invention relates to hydroxyapatite doped with Fe ions and Fe ions which partially substitute the calcium ions in the crystal lattice. The hydroxyapatite is characterized by an intrinsic magnetism of 0.05 to 8 emu/g, measured by applying a magnetic field of 34 Oe, due to the presence of magnetic nano-domains in the crystal lattice of HA, given the limited amount of magnetic secondary phases present, less than about 3% by volume. 1. A hydroxyapatite comprising calcium ions and phosphate ions in a crystal lattice , characterized in that it is doped with Fe ions and Fe ions , which partially substitute said calcium ions in said crystal lattice in a quantitative ratio Fe/Fe of 1 to 4 , has magnetism of 0.05 to 8 emu/g , measured by applying a magnetic field of 34 Oe , due to the presence of magnetic nano-domains in the lattice of hydroxyapatite , and comprises an amount of secondary magnetic phases below about 3 vol %.2. The hydroxyapatite according to claim 1 , wherein said magnetism is of 0.1 to 5 emu/g claim 1 , recorded by applying a magnetic field of 34 Oe.3. The hydroxyapatite according to or claim 1 , wherein said ratio Fe/Fe is of 2 to 3.5.4. The hydroxyapatite according to claim 1 , comprising an amount of secondary magnetic phases≦2 vol %.5. The hydroxyapatite according to claim 1 , having a ratio (Fe+Ca)/P of 1.5 to 1.9.6. The hydroxyapatite according to claim 1 , in the form of nanoparticles having a width of 5-10 nm to 20-30 nm and a length up to 80-150 nm claim 1 , or in the form of aggregates/granules of said nanoparticles.7. The hydroxyapatite according to claim 6 , wherein said nanoparticles comprise spherical voids of 2-5 nm.8. The hydroxyapatite according to claim 1 , loaded with biological substances selected in the group consisting of proteins claim 1 , genes claim 1 , stem cells claim 1 , growth factors and vascularization factors; or loaded with active substances or drugs.9. A biomimetic bone or osteocartilage substitute comprising a ...

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Номер записи: 67

23-05-2013 дата публикации

Medical devices having improved performance

Номер: US20130129793A1

Автор: Frederick Strickler, Shaina Brito

Принадлежит: Boston Scientific Scimed Inc

In accordance with various aspects of the invention, implantable and insertable medical devices are provided, which contain one or more polymeric regions. In one aspect, the polymeric regions comprise (a) a block copolymer that comprises a polyaromatic block and a polyalkene block admixed with (b) a sulfonated high Tg polymer. In another aspect, the polymeric regions comprise a block copolymer that comprises (a) a sulfonated polymer block and (b) fluorinated polymer block.

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Номер записи: 68

30-05-2013 дата публикации

Optical material and method for modifying the refractive index

Номер: US20130138093A1

Автор: Candido D. Pinto, Dharmendra Jani, Jay F. Kunzler, Li Ding, Wayne H. Knox

Принадлежит: Bausch and Lomb Inc, UNIVERSITY OF ROCHESTER

An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.

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Номер записи: 69

06-06-2013 дата публикации

Peg based hydrogel for peripheral nerve injury applications and compositions and method of use of synthetic hydrogel sealants

Номер: US20130142781A1

Автор: Alex Aimetti, Brian Hess, Francis M. Reynolds, Jonathan R. SLOTKIN, Robert S. Langer, Timothy O'Shea

Принадлежит: Invivo Therapeutics Corp

Hydrogels that may be used for treating peripheral nerves and related methods are provided. Synthetic hydrogel sealants, methods of forming synthetic hydrogel sealants, and the use of synthetic hydrogel sealants are provided.

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Номер записи: 70

06-06-2013 дата публикации

Bioabsorbable device having composite structure for accelerating degradation

Номер: US20130144376A1

Автор: George Landau, Vipul Dave

Принадлежит: Cordis Corp

A medical device has a structure made of a first biodegradable and/or bioabsorbable material and a second biodegradable and/or bioabsorbable material encapsulating a degradation additive incorporated into the first biodegradable and/or bioabsorbable material. The second biodegradable and/or bioabsorbable material has a degradation rate that is faster than the degradation rate of the first biodegradable and/or bioabsorbable material such that the structure experiences a period of accelerated degradation upon release of the degradation additive following sufficient degradation of the second biodegradable and/or bioabsorbable material.

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Номер записи: 71

13-06-2013 дата публикации

HYDROXYAPATITE TISSUE FILLER AND ITS PREPARATION AND USE

Номер: US20130149348A1

Автор: BEULING Nienke, BEZEMER Mariska, DE GROOT Klaas, VAN DE MORTEL Nol

Принадлежит: Cam Bioceramics B.V.

The invention pertains to a biocompatible composition, suitable for use in soft or hard tissue augmentation, wherein the composition is an aqueous suspension containing a carrier fraction of ceramic particles of less than μm and an augmentation fraction of ceramic particles of at least μm. The ceramics typically include calcium phosphate. The composition is a may be used in soft tissue repair as well as hard bone replacement. It advantageously avoids the need for foreign body materials which are conventionally applied to stabilize augmentation suspensions. 1. A biocompatible composition , suitable for use in soft or hard tissue augmentation , wherein the composition is an aqueous suspension containing a carrier fraction of ceramic particles of less than 15 μm and an augmentation fraction of ceramic particles of at least 20 μm.2. The composition according to claim 1 , wherein said ceramic particles comprise calcium phosphate.3. The composition according to claim 1 , wherein said carrier particles are smaller than 10 μm.4. The composition according to claim 3 , wherein said carrier particles are preferably 20-1000 nm.5. The composition according claim 1 , wherein more than 50% of the total volume of particles in said carrier fraction is in singular form.6. The composition according to claim 1 , wherein said carrier fraction comprises hydroxyapatite (HA) and/or tricalcium phosphate (TCP).7. The composition according to claim 1 , wherein the weight ratio of said augmentation fraction and said carrier fraction is 0.5:1 to 15:1.8. The composition according to claim 1 , wherein the composition is suitable for soft tissue augmentation claim 1 , said composition being injectable claim 1 , comprising augmentation particles of 20-100 μm and having a surface porosity of less than 30%.9. The composition according to claim 1 , wherein the composition is suitable for hard tissue augmentation claim 1 , said composition comprising augmentation particles of 100 μm to 4 mm and having ...

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Номер записи: 72

13-06-2013 дата публикации

Coatings for drug delivery devices

Номер: US20130150460A1

Автор: Stephen Dirk Pacetti

Принадлежит: Advanced Cardiovascular Systems Inc

A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof.

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Номер записи: 73

20-06-2013 дата публикации

BIOMIMETIC TISSUE SCAFFOLD AND METHODS OF MAKING AND USING SAME

Номер: US20130157360A1

Автор: March John C., Sung Jong Hwan, Yu Jiajie

Принадлежит: CORNELL UNIVERSITY

Three-dimensional biomimetic tissue scaffolds, as well as methods of manufacture of these scaffolds. The method is fully customizable to create a biomimetic tissue scaffold with shapes, densities, and geometries similar or identical to the tissue it imitates. For example, physiologically realistic collagen/PEG villi created using the method are designed to have a high-aspect ratio and curvature similar to villi found in the human small intestine. Accordingly, the biomimetic tissue scaffolds serve as an improved in vitro model for a wide variety of physiological research, as well as pharmacological testing and drug, compound, and/or metabolite uptake by cells growing on the scaffold, among many other uses. 1. A method for making a three-dimensional biomimetic scaffold capable of supporting growth of a cell , the method comprising the steps of:forming a first three-dimensional shape in a first mold;filling at least a portion of the three-dimensional shape in the first mold with a first polymerizable compound;causing said first polymerizable compound to polymerize to form a three-dimensional scaffold, wherein said three-dimensional scaffold is complementary to said three-dimensional shape; andremoving said three-dimensional scaffold from said first mold.2. The method of claim 1 , wherein said first mold comprises a plastic.3. The method of claim 1 , wherein said three-dimensional shape is formed using laser ablation.4. The method of claim 1 , wherein said first mold comprises a plurality of three-dimensional indentations.5. The method of claim 4 , wherein each of said plurality of indentations has a maximum height and a maximum width claim 4 , and further wherein for a majority of said plurality of indentations the maximum height of said indentation is greater than the maximum width of said indentation.6. The method of claim 5 , wherein a majority of said plurality of indentations have a conical shape.7. The method of claim 1 , wherein said first polymerizable compound ...

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Номер записи: 74

27-06-2013 дата публикации

Patellar implants

Номер: US20130166035A1

Автор: Ryan Lloyd Landon

Принадлежит: Smith and Nephew Inc

A patellar implant is provided being of a two part construction having a strong base portion 32, 54, 72 and 92 (manufactured from a metal material or other medical grade strong material) with a molder outer material 34, 62, 80 and 100 (manufactured from a polymeric material or other softer, smoother material) at least on one side to provide a smooth friction surface to contact the femoral portion of a patient's knee.

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Номер записи: 75

04-07-2013 дата публикации

Stimuli Responsive Nanofibers

Номер: US20130171331A1

Автор: Jie Wen, Patrick Guire, Tahmina Naqvi

Принадлежит: Individual

A stimuli responsive nanofiber that includes a stimuli responsive polymer, such as a thermally responsive polymer, and a cross-linking agent having at least two latent reactive activatable groups. The nanofiber may also include a biologically active material or a functional polymer. The stimuli responsive nanofiber can be used to modify the surface of a substrate. When the nanofiber includes a thermally responsive polymer, the physical properties of the surface can be controlled by controlling the temperature of the system, thus controlling the ability of the surface to bind to a biologically active material of interest.

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Номер записи: 76

04-07-2013 дата публикации

Round or anatomical type silicone prosthesis having shell with enhanced durability and method for manufacturing same

Номер: US20130172993A1

Автор: Won Seok Yu

Принадлежит: Individual

A silicone prosthesis including a silicone shell, which has superior texture and comfort when implanted in the body, minimizes stress concentration that may arise when wearing for a long time by eliminating the difference in physical characteristics and stress in all parts of the shell, due to the silicone prosthesis having a uniform thickness, increases resistance to fatigue fracture so as to maximize the safety and lifespan of the silicone prosthesis, and which controls the flow of the silicone in various angles, thereby providing a round or an anatomical type silicone prosthesis having a shell with enhanced durability and a uniform thickness.

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Номер записи: 77

11-07-2013 дата публикации

Polymers for intraocular lenses

Номер: US20130178555A1

Автор: Jose A. Ors, Patrick H. Benz

Принадлежит: Benz Research and Development Corp

The present invention provides optic portions, intraocular lenses, and polymers for use in manufacturing optic portions and intraocular lenses. The optic portions include a polymer that comprises (a) one or more alkoxyalkyl methacrylate monomers and/or one or more alkoxyalkyl acrylate monomers that are incorporated in the polymer; (b) one or more hydroxyalkyl methacrylate monomers and/or one or more hydroxyalkyl acrylate monomers that are incorporated in the polymer; and (c) optionally, one or more crosslinking agents that are incorporated in the polymer.

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Номер записи: 78

25-07-2013 дата публикации

CROSS-LINKED BIOACTIVE HYDROGEL MATRICES

Номер: US20130189371A1

Автор: Hill Ronald Stewart, Klann Richard Chris, Lamberti Francis Vincent

Принадлежит: PIONEER SURGICAL ORTHOBIOLOGICS, INC.

The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking. 1. A bone implant material formed of a molded composition having a predetermined shape and comprising: a crosslinked bioactive hydrogel matrix comprising a polyglycan crosslinked to a polypeptide , and at least one enhancing agent selected from the group consisting of polar amino acids , intact collagen , divalent cation chelators , and combinations thereof; and an osteoinductive or osteoconductive material comprising hydroxyapatite.2. The bone implant material of claim 1 , wherein the polyglycan is a polysaccharide or a sulfated polysaccharide.3. The bone implant material of claim 2 , wherein the polyglycan is selected from the group consisting of glycosaminoglycans claim 2 , glucosaminoglycans claim 2 , dextran claim 2 , heparan claim 2 , heparin claim 2 , hyaluronic acid claim 2 , alginate claim 2 , agarose claim 2 , carageenan claim 2 , amylopectin claim 2 , amylose claim 2 , glycogen claim 2 , starch claim 2 , cellulose claim 2 , chitin claim 2 , heparan sulfate claim ...

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Номер записи: 79

08-08-2013 дата публикации

X-ray visible medical device and preparation method thereof

Номер: US20130202535A1

Автор: Catherine Ann SHASTEEN, Min Park, Seok Min KWON, Suk Wha KIM, Sung Yoon Choi, Tae Hyun CHOI, Young Bin Choy

Принадлежит: SNU R&DB FOUNDATION

The present invention relates to an X-ray visible medical device comprising a medical device and a layer bound onto the medical device, wherein the layer is composed of an X-ray contrast material or a composite of the X-ray contrast material and a biocompatible polymer. Also disclosed is a method for preparing the X-ray visible medical device.

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Номер записи: 80

08-08-2013 дата публикации

Filler composition for tissue reinforcement

Номер: US20130203856A1

Автор: Byung Su Kim, Eui Jin Hwang, Eun Ju Oh, Il Hwan Cho, Jun Seok Yeom, Jung Kyu Park, Moo Seok Seo, Sei Kwang Hahn, Young Soo Park

Принадлежит: Academy Industry Foundation of POSTECH, Shin Poon Pharmaceutical Co Ltd

The present invention relates to a filler composition for tissue reinforcement, including hyaluronic acid and alkylene diamine crosslinked hydrogel. The filler composition exhibits the positive physical properties required for tissue reinforcement, such as biocompatibility and swelling ability, as well as useful effects in that the same can remain in vivo for a long time.

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Номер записи: 81

15-08-2013 дата публикации

Synthesis of Amorphous Calcium Phosphate or Poorly Crystalline Calcium Phosphate Powders by Using Ca Metal

Номер: US20130209377A1

Автор: Ahmet Cuneyt Tas

Принадлежит: Individual

The present invention relates to the synthesis of bioceramics, in particular, of amorphous or cryptocrystalline calcium phosphates.

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Номер записи: 82

15-08-2013 дата публикации

Biodegradable ocular implant

Номер: US20130209538A1

Автор: Jodhbh Metha, Subramanian Venkatraman, Tina Wong, Yin Chiang Freddy Boey

Принадлежит: NANYANG TECHNOLOGICAL UNIVERSITY, SINGAPORE HEALTH SERVICES PTE LTD

The present invention relates to a biodegradable ocular implant for sustained drug delivery, comprising a first layer comprising a first biodegradable polymer, wherein the first layer contains a drug dispersed or dissolved therein. A multi-layered biodegradable ocular implant is also disclosed.

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Номер записи: 83

15-08-2013 дата публикации

PEPTIDE HAVING THE ABILITY TO REGENERATE BONE TISSUE AND FOR BINDING TO APATITE

Номер: US20130210736A1

Автор: Chung Chong-Pyoung, Lee Jue- Yeon, Park Yoon-Jeong, Rhee Sang Hoon

Принадлежит: NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.

The present invention relates to a peptide having bone tissue regeneration capacity and binding to surface of apatite, and more particularly, to a peptide having bone tissue regeneration capacity and specifically binding to a surface of apatite mineral, capable of being stably immobilized to the surface of apatite mineral to retain effective activity and exhibit bone regeneration effects for a long time, by linking an amino acid sequence having bone tissue regeneration capacity and an amino acid sequence having apatite-binding capacity to each other to thereby provide a peptide having both bone-forming effects and binding capacity to the surface of apatite mineral, and a composition for bone tissue regeneration, containing the peptide. The peptide having binding capacity to the apatite mineral and bone tissue regeneration capacity according to the present invention binds to the surface of apatite to thereby be present in a stable state, and thus can be used in a bone replacement material for dental or orthopedic application, and metal, natural polymers, or synthetic polymers, coated with apatite; promote transition, proliferation, and differentiation of cells associated with regeneration and eventually maximize bone tissue regeneration; and can be stably present while maintaining peptide activity when being grafted into the body and thus is useful in development of the bone tissue regeneration therapeutic technology using the peptide. 1. A peptide having bone tissue regeneration capacity and binding to apatite , in which at least one peptide selected from the group consisting of amino acid sequences of SEQ ID NO: 1 to SEQ ID NO: 35 and at least one peptide selected from the group consisting of amino acid sequences of SEQ ID NO: 36 to SEQ ID NO: 39 are linked to each other.2. A peptide having bone tissue regeneration capacity and binding to apatite , wherein the peptide is represented by an amino acid sequence of SEQ ID NO: 40.3. A bone graft material in which the ...

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Номер записи: 84

15-08-2013 дата публикации

BIOMATERIAL COMPOSITIONS

Номер: US20130210953A1

Автор: Bonewald Lynda F., Kilway Kathleen V., Schuman Thomas P.

Принадлежит: Curators of the University of Missouri

Biomaterial compositions comprising organosilicon monomers (such as silorane monomers) and chemical curing systems or dual chemical/light curing systems, in conjunction with optional tetraoxaspiro[5.5]undecanes (“TOSUs”) and/or fillers. The present invention is directed to biomaterial compositions, as well as methods for manufacturing the same, and methods of using the compositions. The biomaterial composition comprises one or more organosilicon monomers (such as a silorane) and a chemical curing system or dual chemicaVlight curing system for polymerizing the 10 monomer(s). The compositions may include one or more tetraoxaspiro[5.5]undecanes “TOSUs”) and/or fillers. Accelerators (such as photoacids), photosensitizers, and/or electron donors may also be included in the composition as appropriate. 1. A biomaterial composition comprising:a polymerizable silorane monomer, anda curing system selected from the group consisting of a chemical curing system and a dual chemical/light curing system.2. The biomaterial composition claim 1 , wherein said silorane monomer is selected from the group consisting of 2 claim 1 ,4 claim 1 ,6 claim 1 ,8-tetramethyl-2 claim 1 ,4 claim 1 ,6 claim 1 ,8-tetrakis-[2-(7-oxabicyclo[4.1.0]hept-3-yl)ethyl]-1 claim 1 ,3 claim 1 ,5 claim 1 ,7-tetraoxa-2 claim 1 ,4 claim 1 ,6 claim 1 ,8-tetrasilacyclooxtane (CYGEP) and methylbis[2-(7-oxabicyclo[4.1.0]hept-3-yl)ethyl]phenylsilane (PHEPSI) claim 1 , and mixtures thereof.3. The biomaterial composition of wherein the curing system comprises a rhodium-based or platinum-based organometallic catalyst.4. The biomaterial composition of wherein said curing system comprises an organometallic catalyst selected from the group consisting of Lamoreaux's catalyst claim 1 , Wilkinson's catalysts claim 1 , Speier's catalyst claim 1 , and Karstedt's catalyst claim 1 , or mixtures thereof.5. The biomaterial composition of wherein said chemical curing system further comprises a photoacid.6. The biomaterial composition ...

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Номер записи: 85

22-08-2013 дата публикации

Implant material, implant component, implant component manufacturing method, laser machining method, and laser machining apparatus

Номер: US20130213553A1

Автор: Masaru Kanaoka, Shigeru Tadano, Taira Ogita

Принадлежит: Hokkaido University NUC, Mitsubishi Electric Corp

In a hydroxyapatite to be joined to another hydroxyapatite or a bone by laser machining (machining of the bone and the hydroxyapatite includes irradiation of laser light on the bone and irradiation of laser light on the hydroxyapatite), to prevent occurrence of a fracture in a junction and in a peripheral portion of the junction during laser machining, the present invention provides an optimum weight ratio of a cordierite or quartz glass component mixed in the hydroxyapatite. As a mixing ratio of the cordierite or quartz glass component, the cordierite or quartz glass component is mixed at least at a weight ratio equal to or higher than 25.7%.

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Номер записи: 86

22-08-2013 дата публикации

THREE-DIMENSIONAL BONE IMPLANT AND METHOD FOR PRODUCING SAME

Номер: US20130216601A1

Автор: Rosenberg Orit

Принадлежит: Sheltagen Medical LTD.

A method for ex vivo production of a three-dimensional bone implant adapted for implantation to a patient, implants produced by such a method, and uses of such implants. The method comprises disposing differentiated osteoblasts on a matrix support comprising at least one of collagen, calcium phosphate, calcium sulfate and tricalcium phosphate; contacting the differentiated osteoblasts on the matrix with autologous blood serum from the patient, comprising at least one of a growth factor and a cytokine; and disposing the differentiated osteoblasts on the matrix support and the medium in a bioreactor, in which production of the bone implant is performed. 1. A method for ex vivo production of a three-dimensional bone implant adapted for implantation to a patient , the method comprising:providing a matrix support comprising at least one selected from the group consisting of collagen, calcium phosphate tricalcium phosphate, and calcium sulfate;providing differentiated osteoblasts disposed on said matrix support;providing autologous blood serum from the patient, said serum comprising at least one of a growth factor and a cytokine;contacting said differentiated osteoblasts on said matrix support to medium comprising said autologous blood serum;disposing said differentiated osteoblasts on said matrix support and said medium within a bioreactor; andproducing the implant within said bioreactor.2. The method of claim 1 , wherein said growth factor is selected from the group consisting of a bone morphogenetic protein claim 1 , an insulin growth factor claim 1 , vascular endothelial growth factor claim 1 , platelet-derived growth factor claim 1 , and fibroblast growth factor.3. The method of claim 1 , further comprising exposing said differentiated osteoblasts on said matrix support to infrasonic mechanical stimulation.4. The method of claim 3 , wherein a frequency of said infrasonic mechanical stimulation is in the range of from about 4 Hz to about 60 Hz and a displacement ...

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Номер записи: 87

22-08-2013 дата публикации

Implantable Devices Including A Mesh And A Perforated Film

Номер: US20130218125A1

Автор: Amin Elachchabi, Daniel Broom, Joshua Stopek

Принадлежит: COVIDIEN LP

The present disclosure relates to implantable medical devices which include at least one mesh and at least one perforated film positioned on the mesh, wherein a portion of the film is positionable away the mesh to allow direct treatment of the contacting mesh tissue and the distal wound or incision site.

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Номер записи: 88

29-08-2013 дата публикации

BIOABSORBABLE POLYMER COMPOSITIONS EXHIBITING ENHANCED CRYSTALLIZATION AND HYDROLYSIS RATES

Номер: US20130225538A1

Автор: Andjelic Sasa, FITZ Benjamin D.

Принадлежит: ETHICON, INC.

A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend. 1. A bimodal polymer composition , comprising:(a) a first amount of a fully amorphous bioabsorbable polymer having a first hydrolysis rate and a first molecular weight distribution; and(b) a second amount of said fully amorphous bioabsorbable polymer having a second hydrolysis rate and a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one;wherein a substantially homogeneous blend of said first and second amounts of said fully amorphous bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent, said substantially homogeneous blend having a hydrolysis rate greater than each of said first hydrolysis rate and said second hydrolysis rate.2. The bimodal polymer composition of claim 1 , wherein the bioabsorbable polymer is selected from the group consisting of poly(lactide) claim 1 , poly(glycolide) claim 1 , poly(dioxanone) claim 1 , poly(ε-caprolactone) claim ...

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Номер записи: 89

05-09-2013 дата публикации

Biocompatible and Biodegradable Composite Material for Use in Surgery and Process for Production Thereof

Номер: US20130230572A1

Автор: Davide Cremascoli, Edgardo Cremascoli

Принадлежит: Novagenit Srl

Composite biomaterials are described, which can be implanted in the human body in various branches of surgery or on the skin in dermocosmetic surgery, which can be formed as membranes or felts and which have properties of rate of absorption in the body and of hydrophilicity that can be modulated.

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Номер записи: 90

05-09-2013 дата публикации

Polymers and methods for ophthalmic applications

Номер: US20130231740A1

Автор: Khalid Mentak

Принадлежит: Key Medical Technologies Inc

The present invention relates to novel methods and materials particularly useful for ophthalmic applications and to methods for making and using the same. More particularly, the present invention relates to relatively soft, optically transparent, foldable, high refractive index materials particularly suited for use in the production of intraocular lenses, contact lenses, and other ocular implants and to methods for manufacturing and implanting IOLs made therefrom.

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Номер записи: 91

12-09-2013 дата публикации

APATITE COMPOSITIONS

Номер: US20130236399A1

Автор: van den Bosch Willem Frederik, Van Duinen Raimond Nicolaas Bruno

Принадлежит:

The present invention relates to an apatite composition comprising 0.001-99.999 wt. % of an apatite and 0.001-99.999 wt. % of a glass carbomer, based on the total weight of the apatite composition. The apatite is preferably a fluoroapatite according to the general formula (I): wherein: M is a cation other than Ca, B is an anion other than P04″, A is F″, 0≦x≦9, 0≦y≦5, and 0≦z≦2, and most preferably Ca(PO)F. The apatite composition is advantageously used as a dental filling material, a denting bonding cement, a bone cement, a bone replacing material, in dental care and cleansing products, glass-ceramics, bone scaffolds and bone substrates, and as a coating material for crowns and bridges. 131-. (canceled)33. The apatite composition according to claim 32 , wherein the apatite is a fluoroapatite.35. The apatite composition according to claim 34 , wherein x=y=0 and z=2.37. The apatite composition according to claim 36 , wherein x=y=z=0 and A is OH.38. The apatite composition according to claim 32 , wherein the poly(dialkylsiloxane) is linear or cyclic.39. The apatite composition according to claim 38 , wherein the alkyl groups of the poly(dialkylsiloxane) are methyl groups.40. The apatite composition according to claim 38 , wherein the poly(dialkylsiloxane) has a kinematic viscosity in the range of about 1 to about 100 claim 38 ,000 cSt at 25° C.41. The apatite composition according to claim 32 , wherein the particles of the fluorosilicate glass powder have an average size of about 10to about 200 μm.42. The apatite composition according to claim 32 , wherein the aqueous acid solution comprises an inorganic acid or an organic acid.43. The apatite composition according to claim 32 , wherein the fluoroapatite composition is in a particulate form.44. The apatite composition according to claim 43 , wherein the particles of the fluoroapatite composition have an average size of about 10to about 200 μm.45. A dental filling material comprising the apatite composition according to ...

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Номер записи: 92

12-09-2013 дата публикации

POLYURETHANES FOR OSTEOIMPLANTS

Номер: US20130236547A1

Автор: Boyce Todd M., Kaes David R., Knaack David A., Shimp Lawrence A., Winterbottom John

Принадлежит: Warsaw Orthopedic, Inc. Orthopedic, Inc.

Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant. 1. A biodegradable polyurethane composite , comprising:a polyurethane matrix formed by reaction of a polyisocyanate with an optionally hydroxylated biomolecule to form a biodegradable polyurethane polymer; anda reinforcement embedded in the matrix, wherein the reinforcement comprises a material selected from the group consisting of bone and bone substitutes.2. The polyurethane composite of claim 1 , wherein the reinforcement comprises a material selected from the group consisting of calcium carbonate claim 1 , calcium sulfate claim 1 , calcium phosphosilicate claim 1 , sodium phosphate claim 1 , calcium aluminate claim 1 , calcium phosphate claim 1 , calcium carbonate claim 1 , hydroxyapatite claim 1 , demineralized bone claim 1 , mineralized bone claim 1 , and combinations and modified forms of the above.3. The polyurethane composite of claim 1 , wherein the biodegradable polyurethane polymer is cross-linked.4. The polyurethane composite of claim 1 , wherein the polyisocyanate is a diisocyanate.5. The polyurethane composite of claim 1 , wherein the polyisocyanate is selected from the group consisting of lysine diisocyanate claim 1 , toluene diisocyanate claim 1 , arginine diisocyanate claim 1 , asparagine diisocyanate claim 1 , glutamine diisocyanate claim 1 , hexamethylene diisocyanate claim 1 , hexane diisocyanate claim 1 , methylene bis-p-phenyl diisocyanate claim 1 , isocyanurate polyisocyanates claim 1 , 1 claim 1 ,4-butane diisocyanate claim 1 , uretdione polyisocyanate claim 1 , and aliphatic claim 1 , alicyclic claim 1 , and aromatic polyisocyanates.6. The polyurethane composite of claim 1 , wherein the ...

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Номер записи: 93

12-09-2013 дата публикации

Biomedical devices containing internal wetting agents

Номер: US20130237631A1

Автор: Azaam Alli, Douglas G. Vanderlaan, Frank F. Molock, JR., Gregory A. Hill, James D. Ford, Kevin P. Mccabe, Robert B. Steffen

Принадлежит: Johnson and Johnson Vision Care Inc

This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.

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Номер записи: 94

12-09-2013 дата публикации

Surgical polymer molded and flexible covering material with or without secondary composite additive materials for providing anti-bacterial and tear resistant properties

Номер: US20130237747A1

Автор: Miguel A. Linares, Miguel A. Linares, JR., Ryan T. Greene

Принадлежит: Linares Medical Devices LLC

A surgically implantable mesh for covering a tear or rupture in a lining associated with an interior body cavity. A mat shaped polymer body has top and bottom spaced apart surfaces which are communicable at intervals by an interior configuration defined in the body and which promotes tissue in-growth following implantation. An antibacterial additive is intermixed with the polymer in a viscous state prior to formation and can included at least one of silver, gold, copper, bronze, or ground bamboo fibers.

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Номер записи: 95

19-09-2013 дата публикации

CALCIUM-CONTAINING STRUCTURES AND METHODS OF MAKING AND USING THE SAME

Номер: US20130243737A1

Автор: Starling L. Brian, Stephan James E.

Принадлежит: CAP BIOTECHNOLOGY INC

The present invention generally relates to calcium-containing structures and methods of making and using the structures. In one aspect, hollow calcium containing microstructures are used in conjunction with bone tissues/by-products to augment bone defects and extend the supply of bone tissues/by-products for bone augmentation. Bonding agents, such as calcium cements, are also used in the preparation of the hollow calcium microstructures combined with bone tissues/by-products or for use in preparing the hollow microstructures. The calcium-containing microstructures of the present invention are also useful as delivery vehicles of nitric oxide and/or nitric oxide containing or producing compounds for a variety of in vitro and in vivo uses. Calcium containing contoured substrates upon which cells/tissues can be grown in vitro for replacement and repair of tissues in vivo that conform in size and shape to the tissue surface to be replaced are also provided. 132.-. (canceled)33. A method of making a calcium-containing substrate , comprising the steps of:(a) obtaining a composition comprising calcium phosphate;(b) contouring said composition into a desired shape to form a contoured composition;(c) culturing cells or tissues onto the contoured composition to form the calcium-containing substrate.34. The method of claim 33 , further comprising the steps of:(d) removing the cultured cells or tissues from the contoured composition; and(e) transplanting the cultured cells or tissues into a patient in need thereof.35. The method of claim 33 , further comprising the step of transplanting the calcium-containing substrate into a patient in need thereof.36. The method of claim 33 , wherein calcium phosphate is hydroxylapatite claim 33 , tribasic calcium phosphate claim 33 , dicalcium phosphate claim 33 , tetracalcium phosphate claim 33 , calcium carbonate claim 33 , calcium oxide claim 33 , glass-containing calcium phosphate claim 33 , or a mixture thereof.37. The method of claim 33 ...

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Номер записи: 96

19-09-2013 дата публикации

PHOTOCHEMICAL ACTIVATION OF SURFACES FOR ATTACHING BIOMATERIAL

Номер: US20130243862A1

Автор: Alferiev Ivan, Chorny Michael, Fishbein Ilia, Levy Robert J., Williams Darryl, Yellen Benjamin

Принадлежит: THE CHILDREN'S HOSPITAL OF PHILADELPHIA

A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell. 1. A water-soluble photo-activatable polymer comprising:(a) a photo-activatable group, wherein the photo-activatable group is adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon;(b) a reactive group, wherein the reactive group is adapted to covalently react with a biomaterial;(c) a hydrophilic group, wherein the hydrophilic group is present in an amount sufficient to make the water-soluble photo-activatable polymer soluble in water; and(d) a polymer precursor.2. The water-soluble photo-activatable polymer of claim 1 , wherein the polymer precursor comprises at least one monomer selected from the group consisting of allylamine claim 1 , vinylamine claim 1 , acrylic acid claim 1 , carboxylic acid claim 1 , alcohol claim 1 , ethylene oxide claim 1 , and acyl hydrazine.3. The water-soluble photo-activatable polymer of claim 1 , wherein the reactive group is a member selected from ...

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Номер записи: 97

26-09-2013 дата публикации

Method for producing implant material

Номер: US20130253657A1

Автор: Masataka Sakane, Yuji Hotta

Принадлежит: Kuraray Co Ltd, University of Tsukuba NUC

The production method of an implant material of the present invention includes step (A): a step of setting a porous ceramic material having substantially unidirectionally arrayed pores at any depth position inside a container, step (B): a step of filling the container with a cell-containing liquid containing at least bone marrow blood and/or peripheral blood, and step (C): a step of applying, on the container, a centrifugal force in the direction along the axis of the container.

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Номер записи: 98

03-10-2013 дата публикации

Particulate substances comprising ceramic particles for delivery of biomolecules

Номер: US20130259942A1

Автор: Christophe Jean Alexandre BARBÉ, Kim Suzanne Finnie, Samuel Knight, Toby Johnston Passioura

Принадлежит: Australian Nuclear Science and Technology Organization

A particulate substance comprising particles of a ceramic matrix bearing a functional group, the functional group being capable of promoting penetration of the particles into cells, and a biomolecule disposed within pores of the particles, the biomolecule being releasable from the particles by dissolution of the ceramic matrix.

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Номер записи: 99

10-10-2013 дата публикации

BONE SUBSTITUTE COMPOSITION

Номер: US20130268088A1

Автор: LIDGREN Lars, Nilsson Malin

Принадлежит: Bone Support AB

An injectable bone mineral substitute material composition with the capability of being hardened in a body fluid in vivo, which comprises at least one calcium phosphate component and at least one calcium sulfate component as a dry mixture mixed with an aqueous liquid, and at least one accelerator, the at least one calcium sulfate component being particulate hardened calcium sulfate, which has a specified particle size that is in order to confer injectablity to the composition. The invention also concerns the bone mineral substitute material produced from the composition as well as methods and uses thereof. 145.-. (canceled)46. A method for fixing a prosthesis comprising:a) mixing a dry powder composition comprising a calcium phosphate component and a calcium sulfate component with an aqueous liquid;b) injecting the resulting composition from step a) into a bone cavity;c) introducing a prosthesis into the bone cavity; andd) allowing the injectable composition to harden in vivo.47. The method of claim 46 , wherein the calcium phosphate component is chosen from tetracalcium phosphate (TTCP) claim 46 , monocalcium phosphate monohydrate (MCPM) claim 46 , dicalcium phosphate dihydrate (DCPD) claim 46 , anhydrous dicalcium phosphate (DCPA) claim 46 , dicalcium phosphate (OCP) claim 46 , tricalcium phosphate (TCP) claim 46 , and octocalcium phosphate (OCP).48. The method of claim 46 , wherein the calcium sulfate component is chosen from a hardened particulate calcium sulfate and a calcium sulfate hemihydrate.49. The method of claim 48 , wherein the hardened particulate calcium sulfate is calcium sulfate dihydrate.50. The method of claim 48 , wherein the calcium sulfate hemihydrate is in the α-form.51. The method of claim 46 , wherein the calcium sulfate component is present in an amount up to 60 wt % of the dry powder composition.52. The method of claim 46 , wherein the calcium sulfate component is present in an amount ranging from 10 wt % to 40 wt % of the dry powder ...

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Номер записи: 100

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