03-10-2013 дата публикации
Номер: US20130261603A1
Принадлежит:
Lutonix, Inc.
Embodiments of the present invention provide a method for treatment of respiratory disorders such as asthma, chronic obstructive pulmonary disease, and chronic sinusitis, including cystic fibrosis, interstitial fibrosis, chronic bronchitis, emphysema, bronchopulmonary dysplasia and neoplasia. The method involves administration, preferably oral, nasal or pulmonary administration, of anti-inflammatory and anti-proliferative drugs (rapamycin or paclitaxel and their analogues) and an additive. 156-. (canceled)57. A device sized and configured for insertion into a passage of a respiratory system , the device comprising a layer overlying an exterior surface of the device , the layer comprising a water insoluble drug for the treatment of the respiratory system and an additive that enhances absorption of the drug into tissue of the respiratory system , wherein:the device is a balloon catheter;the water insoluble drug is chosen from paclitaxel and rapamycin; andthe additive is at least one of a surfactant and a chemical compound, wherein the chemical compound is chosen from amino alcohols, hydroxyl carboxylic acid, ester, anhydrides, hydroxyl ketone, hydroxyl lactone, hydroxyl ester, sugar phosphate, sugar sulfate, ethyl oxide, ethyl glycols, amino acids, peptides, proteins, sorbitan, glycerol, polyalcohol, phosphates, sulfates, organic acids, esters, salts, vitamins, combinations of amino alcohol and organic acid, and their substituted molecules.5862-. (canceled)63. The device according to claim 57 , wherein the surfactant is chosen from ionic claim 57 , nonionic claim 57 , aliphatic claim 57 , and aromatic surfactants claim 57 , PEG fatty esters claim 57 , PEG omega-3 fatty esters claim 57 , ether claim 57 , and alcohols claim 57 , glycerol fatty esters claim 57 , sorbitan fatty esters claim 57 , PEG glyceryl fatty esters claim 57 , PEG sorbitan fatty esters claim 57 , sugar fatty esters claim 57 , PEG sugar esters claim 57 , and derivatives thereof.64. The device ...
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