ПОЛОВОЛОКОННОЕ МЕМБРАННОЕ УСТРОЙСТВО ДЛЯ ОЧИСТКИ КРОВИ

Изобретение относится к медицинской технике. Половолоконное мембранное устройство для очистки крови, в котором емкость заполнена половолоконной мембраной. Половолоконная мембрана содержит гидрофобный полимер, гидрофильный полимер и жирорастворимый витамин. Количество жирорастворимого витамина на внутренней поверхности половолоконной мембраны составляет 10 мг/мили более и 300 мг/мили менее. Кислородопроницаемость емкости составляет 1,8×10-10 см×см/(см×с×см рт.ст.) или менее. Материал емкости выбран из группы, состоящей из винилхлоридной смолы, поликарбонатной смолы, abs смолы, акриловой смолы, полиэфирной смолы, полиолефиновой смолы, полисульфоновой смолы, полифениленоксидной смолы и полиацеталевой смолы. 7 з.п. ф-лы, 13 пр., 2 табл., 3 ил.

ДИАЛИЗНЫЙ АППАРАТ С ПУЛЬТОМ УПРАВЛЕНИЯ

Изобретение относится к медицине и предназначено для альтернативной стационарной помощи и самопомощи диализным больным. Аппарат имеет сенсорный экран, который можно регулировать универсально до желательного вертикального положения и блокировать в желательном отрегулированном положении. Вследствие этого сенсорный экран может удерживаться в положении относительно положения человека, управляющего диализным аппаратом, которое позволяет удобно дотягиваться до сенсорного экрана, независимо от положения упомянутого человека. Таким образом, изобретение дает возможность самому пациенту использовать аппарат. 4 з.п. ф-лы, 5 ил.

УДАЛЕНИЕ И ВОССТАНОВЛЕНИЕ СОДЕРЖАНИЯ КЛЕТОК В ОРГАНАХ И ТКАНЯХ

Группа изобретений относится к медицине, а именно к тканевой инженерии. Предложена лишенная клеток путем перфузии сосудистая ткань свиньи, коровы, овцы, собаки или человека, содержащая лишенный клеток внеклеточный матрикс указанной ткани. При этом указанный внеклеточный матрикс включает сосудистое дерево. Указанный лишенный клеток внеклеточный матрикс указанной ткани сохраняет большую часть жидкости, введенной в указанное сосудистое дерево лишенного клеток внеклеточного матрикса. Предложен способ лишения ткани клеток методом перфузии, а также часть органа, лишенного клеток методом перфузии. Группа изобретений позволяет обеспечить возможность эффективной реконструкции органа или ткани. 4 н. и 12 з.п. ф-лы, 2 ил.

СПОСОБ И УСТРОЙСТВО ДЛЯ ГЕМОДИАФИЛЬТРОВАЛЬНОГО ПРИЕМНО-ВЫВОДНОГО МОДУЛЯ

Изобретение относится к способу и устройству для гемодиафильтровального приемно-выводного модуля. Устройство включает диализный аппарат, контур искусственного кровообращения, сообщающиеся с диафильтровальным модулем, содержащим первый трубопровод (120), предназначенный для приема первой жидкости из диализного аппарата и для выпуска диализной жидкости в указанный аппарат, второй трубопровод (64), селективно сообщающийся с первым трубопроводом с обеспечением селективного поступления во второй трубопровод отводимого количества первой жидкости из первого трубопровода. Второй трубопровод сообщается, по меньшей мере, с одним стерилизационным фильтром (92) для создания замещающей жидкости, подаваемой в контур искусственного кровообращения. Блок управления (110) действует от параметров жидкости, а именно первой жидкости и диализной жидкости, и/или от параметра крови, находящейся в контуре искусственного кровообращения. Блок управления выполнен с обеспечением предотвращения поступления потока замещающей ...

УСТРОЙСТВО ДЛЯ СОРБЦИОННОЙ ОЧИСТКИ ОТРАБОТАННОГО ДИАЛИЗАТА

Изобретение относится к медицинской технике. Устройство для сорбционной очистки отработанного диализирующего или перитонеального растворов содержит полый корпус, наполненный сорбентом, два фильтра для крупнодисперсной и среднедисперной фильтрации и две крышки со штуцерами для подключения магистралей. Корпус имеет подковообразную форму с горловинами, имеющими пазы под уплотнительные кольца и пазы для крепления крышек. Крышки располагаются на горловинах и имеют крепежные выступы для крепления к горловинам корпуса. Внутренняя полость корпуса имеет подковообразную форму, сужающуюся к горловинам. Фильтры располагаются в горловинах корпуса. Штуцеры для подключения магистралей направлены в одну сторону. Выходная крышка имеет датчик проводимости для контроля состава очищенного раствора, включающий разъем, установленный с внешней стороны крышки, и подсоединенные к нему контакты из нержавеющей стали, один из которых выполнен в форме кольца, вклеенного в выходную крышку, а второй - в форме иглы, установленной ...

МНОГОКАНАЛЬНАЯ СКООРДИНИРОВАННАЯ ИНФУЗИОННАЯ СИСТЕМА

Изобретение относится к медицинской технике. Система содержит первое насосное устройство, которое подает первый инфузат, предпочтительно медикамент, во внутривенную инфузионную линию, и второе насосное устройство, которое подает второй инфузат, предпочтительно нейтральный раствор носитель, во внутривенную линию. Измерительное устройство определяет количество неподанного первого инфузата, остающегося в приемнике. Система управления связана с первым и вторым устройствами подачи и измерительным устройством для определения оптимальной скорости потока инфузии первого инфузата на основе определенного количества неподанного первого инфузата, остающегося в системе, заранее определенного объема жидкости для вливания, и заранее заданного периода времени инфузии, и для управления первым модулем подачи. Раскрыт способ инфузии второго инфузата на основе определения общего объема первого инфузата. Технический результат состоит в обеспечении точного вливания медикамента в течение заданных периодов времени ...

ВЕЩЕСТВА, ЗАЩИЩАЮЩИЕ КЛЕТКИ ОТ РАССЕЧЕНИЯ ПРИ СБОРЕ МИКРОФИЛЬТРАЦИЕЙ

Изобретение относится к биотехнологии, в частности к способу сбора продукта из культивируемых клеток диафильтрацией и составу для диафильтрации. Способ включает: (a) обеспечение ретентата для диафильтрации, причем указанный ретентат представляет собой ретентат, полученный после сбора культивируемых клеток микрофильтрацией; (b) добавление к ретентату буфера, содержащего неионогенное поверхностно-активное вещество; и (c) проведение диафильтрации ретентата, содержащего указанный буфер, тем самым осуществляя сбор продукта из культивируемых клеток. Изобретение позволяет повысить эффективность диафильтрации, а именно снизить мутность, и увеличить степень извлечения продукта из ретентата. 2 н. и 22 з.п. ф-лы, 3 табл.,2 пр.

Способ искусственного кровообращения у реципиента сердца при его трансплантации и система для его осуществления

Группа изобретений относится к медицине и медицинской технике, а именно к системе для искусственного кровообращения (ИК) у реципиента сердца при трансплантации сердца и способу ИК у реципиента сердца при его трансплантации. Система для ИК содержит первую венозную канюлю для подключения к бедренной вене, первую, вторую венозные магистрали, центрифужный и роликовый насосы, первый, второй оксигенаторы, первый, второй и третий тройники-разветвители; первую и вторую артериальные магистрали, артериальную канюлю с луер-портом для подключения к бедренной артерии, первый и второй прямые коннекторы, кардиотомный резервуар (КТР), магистраль раневого отсоса, канюлю дренажа левого желудочка, магистраль дренажа левого желудочка, вторую венозную канюлю для подключения к верхней полой вене (ВПВ), гемоконцентратор, прямой коннектор с луер-портом и магистралью для подключения датчика давления, магистраль газовоздушной смеси первого оксигенатора, магистраль газовоздушной смеси второго оксигенатора. Первая ...

Применение альгинатных олигомеров в качестве антикоагулянтов крови

В изобретении предложен альгинатный олигомер из 2-75 мономерных остатков, где указанные мономерные остатки не несут сульфатную группу, для применения в качестве антикоагулянта крови в клинических и неклинических применениях, включая условия in vivo, ex vivo и in vitro. Дополнительно в изобретении предложено применение такого альгинатного олигомера в получении продукта или устройства, имеющего пониженную способность вызывать коагуляцию крови, где указанный альгинатный олигомер предоставлен в или на поверхности указанного продукта или устройства, а также способ предупреждения или ингибирования коагуляции крови in vitro или ex vivo, включающий приведение в контакт композиции, содержащей плазму крови, или материала, выбранного из трансплантированной ткани, или продукта или устройства, или их части, которые при применении вступают в контакт с кровью или продуктом, полученным из крови, с которым указанная композиция контактирует или может контактировать, с альгинатным олигомером из 2-50 мономерных ...

УСТРОЙСТВО ДЛЯ СОРБЦИОННОЙ ОЧИСТКИ ОТРАБОТАННОГО ДИАЛИЗАТА

Устройство для сорбционной очистки отработанного диализирующего или перитонеального растворов, содержащее корпус, крупнодисперсные и среднедисперсные фильтры и две крышки со штуцерами для подключения магистралей, отличающееся тем, что профиль корпуса устройства имеет подковообразную форму, штуцеры для подключения магистралей расположены с одной стороны, выходная крышка имеет датчик проводимости для контроля состава очищенного раствора, состоящий из разъема, установленного с внешней стороны крышки, и подсоединенных к нему контактов из нержавеющей стали, один из которых выполнен в форме кольца, а второй - в форме иглы, установленной в геометрическом центре первого контакта при помощи предусмотренной в выходной крышке крестовины.

СПОСОБ ЗАМЕЩЕНИЯ ДЕФЕКТА ДНА ВЕРТЛУЖНОЙ ВПАДИНЫ ПРИ ЭНДОПРОТЕЗИРОВАНИИ ТАЗОБЕДРЕННОГО СУСТАВА У ПАЦИЕНТОВ, НАХОДЯЩИХСЯ НА ХРОНИЧЕСКОМ ГЕМОДИАЛИЗЕ

Изобретение относится к медицине, а именно к травматологии и ортопедии, и может быть использовано для замещения дефекта дна вертлужной впадины при эндопротезировании тазобедренного сустава у пациентов, находящихся на хроническом гемодиализе. Для этого осуществляют импакцию губчатой костной крошки. При этом к губчатой костной крошке добавляют альфакальцидол в соотношении 5:1. После выполнения импакционной костной пластики интраоперационную рану и окружающую ее кожу облучают ультрафиолетом с длиной волны 200-300 нм и количеством энергии на фотон 3,94-4,43 эВ в течение 2-х минут. Способ обеспечивает сокращение сроков восстановительного периода после операции и обеспечивает возможность более ранней осевой нагрузки на оперированную нижнюю конечность в результате формирования прочной костной опоры за счет стимуляции и сокращения сроков ремоделирования губчатой костной крошки в дефекте вертлужной впадины, усиления остеоинтеграции ацетабулярного компонента эндопротеза тазобедренного сустава. 1 ...

Система и способ вспомогательного кровообращения при хирургических вмешательствах на печени

Группа изобретений относится к медицине и медицинской технике. Система для проведения вспомогательного кровообращения при хирургических вмешательствах на печени содержит первую канюлю для подключения к нижней полой вене, вторую канюлю для подключения к воротной вене, канюлю аспиратора, первый-пятый тройники-разветвители, резервуар крови, центрифужный насос, аппарат для проведения непрерывной заместительной почечной терапии, первый и второй луер-порты перфузионного контура, магистраль вакуумного отсоса для создания отрицательного давления внутри резервуара крови и двухпросветный катетер с первым и вторым луер-портами двухпросветного катетера. Первая и вторая канюли входят в перфузионный контур и соединены последовательно через первый тройник-разветвитель с первым портом второго тройника-разветвителя, второй порт которого соединен с входом центрифужного насоса, а выход центрифужного насоса последовательно через первый-второй порты четвертого и пятого тройников-разветвителей соединен с первым ...

ЗАКРЫВАЮЩИЙ ЭЛЕМЕНТ ЛОВУШКИ ДЛЯ ПУЗЫРЬКОВ В ЭКСТРАКОРПОРАЛЬНОМ КОНТУРЕ ДЛЯ ГЕМОДИАЛИЗА

... 1. Элемент (12) ловушки (4, 10) для пузырьков в контуре (1) экстракорпорального гемодиализа, имеющий:- корпус, задающий внутреннее пространство указанного элемента;- внутреннюю стенку (14), разделяющую внутреннее пространство элемента (12) на первое и второе отделения (15, 16);- порт (62) давления, выполненный с возможностью подсоединения к датчику давления для измерения давления внутри ловушки (4, 10) для пузырьков, и- выводящее отверстие (63) для выведения сгустков (С), находящихся внутри ловушки (4, 10) для пузырьков,причем порт (62) давления открыт в первое отделение (15) элемента (12), а выводящее отверстие (63) - в его второе отделение (16), характеризующийся тем, чтоэлемент (12) дополнительно снабжен входом (66) для воздуха, открытым во второе отделение указанного элемента.2. Элемент (12) по п.1, в котором второе отделение (16) выполнено сужающимся в направлении выводящего отверстия (63).3. Элемент (12) по п.2, в котором второе отделение (16) имеет форму, близкую к коническому каналу ...

УСТРОЙСТВО ДЛЯ ОЧИСТКИ КРОВИ

... 1. Устройство для очистки крови для использования в системе очистки крови, содержащееочиститель крови, внутренний объем которого разделяется на канал для потока крови и канал для другого потока, причем очиститель крови имеет первую входную часть, соединенную с одним концом канала для потока крови, первую выходную часть, соединенную с другим концом канала для потока крови, вторую входную часть, соединенную с одним концом канала для другого потока, и вторую выходную часть, соединенную с другим концом канала для другого потока;артериальный контур, связанный с первой входной частью;венозный контур, связанный с первой выходной частью;контур диализата, связанный со второй входной частью;контур текучих отходов, связанный со второй выходной частью и через который проходят текучие отходы от второй выходной части;первый контур, связанный с венозным контуром и через который проходит первая текучая среда; ивторой контур, связанный с артериальным контуром, венозным контуром или первым контуром и через ...

ГЕМОДИАФИЛЬТРОВАНЫЙ/ГЕМОФИЛЬТРОВАНЫЙ КАРТРИДЖ

... 1. Гемодиафильтровальный/гемофильтровальный картридж с промежуточным разбавлением, содержащий корпус, имеющий первый торец и противоположный второй торец и сообщающийся с впуском для крови, выпуском для крови и впуском и выпуском для диализата, первую ступень гемодиафильтрации, включающую первый фильтрующий элемент, расположенный между первым и вторым торцами корпуса картриджа, причем впуск для крови сообщается с первым фильтрующим элементом у первого торца с обеспечением протекания крови через указанный фильтрующий элемент в сторону второго торца, вторую ступень гемофильтрации, включающую второй фильтрующий элемент, расположенный между первым и вторым торцами корпуса картриджа, причем выпуск для крови сообщается со вторым фильтрующим элементом, и межступенчатый соединитель, расположенный у второго торца корпуса картриджа, ограничивающий межступенчатую коллекторную полость, обеспечивающую протекание крови, выпущенной из первой ступени гемодиафильтрации, через второй фильтрующий элемент ...

Gasblasen- und/oder Festkörperdetektor auf Ultraschallbasis, Dialysegerät und Verfahren für einen derartigen Detektor

Offenbart ist ein Gasblasen- und/oder Festkörperdetektor auf Ultraschallbasis mit einem Ultraschall-Sender zum Senden eines Ultraschalls durch ein zu prüfendes Medium hindurch, wobei der Ultraschall von einem Ultraschall-Empfänger empfangbar ist. Ein Energieeintrag des Ultraschalls in ein zu überwachendes Medium kann hierbei begrenzt und/oder überwacht und/oder angepasst werden.

Gefäßport, insbesondere für die Hämodialyse

ANTITHROMBOTISCHES BLUTBEHANDLUNGSSYSTEM.

Kassette mit einem Sensor zur Bestimmung der Differenz eines ersten und eines zweiten Flüssigkeitsstroms

Die Erfindung bezieht sich auf das Bilanzieren von Flüssigkeitsströmen in einem Dialysesystem. Insbesondere bezieht sich die Erfindung auf eine Kassette zum Fördern eines ersten und eines zweiten Flüssigkeitsstroms in einem Dialysesystem, wobei der erste und der zweite Flüssigkeitsstrom medizinische Flüssigkeitsströme wie beispielsweise Dialysatströme oder Blutströme sein können, wobei die Kassette einen Sensor als Vorrichtung zur Bilanzierung des ersten und des zweiten Flüssigkeitsstroms aufweist und wobei der Sensor einen ersten Kanal für den ersten Flüssigkeitsstrom und einen zweiten Kanal für den zweiten Flüssigkeitsstrom aufweist. Ferner bezieht sich die Erfindung auf eine Dialysevorrichtung, die ausgestaltet ist, zumindest eine Kassette aufzunehmen, die wie oben dargelegt ausgestaltet ist. Des Weiteren bezieht sich die vorliegende Erfindung auf eine Anordnung, durch die zwei Kanäle für den ersten und den zweiten Flüssigkeitsstrom ausgebildet werden. Zusätzlich bezieht sich die Erfindung ...

Verschlusskupplung

Kupplungseinheit, bestehend aus einem Nippel und einem Kupplungsteil, einer Anordnung zum Abzweigen einer Flüssigkeit aus einem Rohr oder einer stationären Einheit oder zum Zuführen bzw. zur Entnahme einer Flüssigkeit aus einer flexiblen Schlauchverbindung in ein Rohr oder in eine stationäre Einheit, wobei ein Teil der Kupplungseinheit mit einem Gewindeabschnitt in ein Rohr oder in eine stationäre Einheit eingeschraubt ist, dadurch gekennzeichnet, dass das Kupplungsteil (26) und das Nippelteil (3) aus einem Verschlussstück (9, 27), das an einem Endabschnitt den Gewindeabschnitt (4) zum Einschrauben in den Rohrstutzen (2) aufweisen kann und an dem anderen Endabschnitt einen weiteren Gewindeabschnitt (14) aufweist, und einem Nippelelement (10) bzw. Kupplungselement (28) zusammengesetzt ist, in das der weitere Gewindeabschnitt (14) eingeschraubt ist, dass in dem Kupplungsteil (26) und dem Nippelteil (3) jeweils ein Ventilkörper (18) und eine Schraubendruckfeder (19) angeordnet sind, die den ...

DIALYSEMASCHINEN MIT EINEM BERÜHRUNGSEMPFINDLICHEN BILDSCHIRM ALS BENUTZERSCHNITTSTELLE

Anschlusseinheit für eine Blutbehandlungsmaschine zum Anschließen der Blutbehandlungsmaschine an einen externen Behälter und Blutbehandlungsmaschine mit einer derartigen Anschlusseinheit

Die vorliegende Erfindung betrifft eine Anschlusseinheit für eine Blutbehandlungsmaschine zum Anschließen der Blutbehandlungsmaschine an einen externen Behälter mit einer maschinenseitigen Leitung welche dazu ausgelegt ist mit der Blutbehandlungsmaschine fluidisch verbunden zu werden, einer behälterseitigen Leitung, welche dazu ausgelegt ist mit dem Behälter fluidisch verbunden zu werden und einem fest mit der maschinenseitigen Leitung und der behälterseitigen Leitung verbundenen Aufsatz, welcher dazu ausgelegt ist an einem Anschlussstutzen des externen Behälters lösbar montiert zu werden, um den externen Behälter fluidisch mit der Blutbehandlungsmaschine zu verbinden; und eine Blutbehandlungsmaschine mit einer derartigen Anschlusseinheit.

Rückschlagventilanordnung, medizinische Funktionsvorrichtung und eine Blutbehandlungsvorrichtung

Die Erfindung betrifft eine Rückschlagventilanordnung (1 0) mit einem Zulauf (205) und einem Ablauf für medizinische Fluide, mit einem Ventilkörper (101), wobei die Rückschlagventilanordnung (100) in einem Ausgangszustand ein Durchströmen eines Arbeitsfluids und/oder eines Sterilisationsfluids durch die Rückschlagventilanordnung (100) in beiden Durchströmungsrichtungen, also vom Zulauf (205) zum Ablauf und umgekehrt, zulässt, und wobei die Rückschlagventilanordnung (100) in einem Betriebszustand nur eine Durchströmungsrichtung des Arbeitsfluids zulässt, wobei die Rückschlagventilanordnung (100) eine Stift-Stiftaufnahme-Verbindung aufweist, welche derart ausgestaltet ist, dass die Rückschlagventilanordnung (100) durch Kraftaufbringung auf die Stift-Stiftaufnahme-Verbindung und/oder durch eine Wegeinprägung auf die Stift-Stiftaufnahme-Verbindung vom Ausgangszustand in den Betriebszustand überführbar ist.

Verfahren und Vorrichtung zur Steuerung der Behandlungsdauer von Behandlungen mit medizintechnischen Geräten

Die vorliegende Erfindung liegt auf dem Gebiet der Steuerung von medizintechnischen Geräten, insbesondere von Blutbehandlungsgeräten wie Dialysegeräte. Sie richtet sich auf eine Vorrichtung und ein Verfahren, bei dem die Dauer der Behandlung eines Patienten mit dem Blutbehandlungsgerät oder der Zeitpunkt des Behandlungsendes individuell vom Bediener des Blutbehandlungsgeräts verändert werden kann, und wobei die Veränderungen über eine Anzahl von Behandlungen patientenindividuell protokolliert werden. Die Möglichkeit der Veränderung der Dauer der Behandlung eines Patienten mit dem Blutbehandlungsgerät oder des Zeitpunkts des Behandlungsendes ist hierbei von den protokollierten Änderungen vorhergehender Behandlungen abhängig.

Verfahren und Vorrichtung zur Vorhersage von einem oder mehreren für den Ausgang einer Blutbehandlung charakteristischen Parametern

Die vorliegende Erfindung betrifft ein Verfahren und eine Vorrichtung zur Vorhersage von einem oder mehreren für den Ausgang einer Blutbehandlung charakteristischen Parametern, wobei es sich bei der Blutbehandlung um eine Behandlung handelt, bei der dem Blut des Patienten über wenigstens eine Membran Flüssigkeit entzogen wird, wobei es sich bei den Parametern um das erlaubte Trinkvolumen, die Über- oder Unterwässerung des Patienten, die Clearance großer Moleküle und/oder um die erlaubte Salzaufnahme handelt, wobei die Vorhersage des erlaubten Trinkvolumens sowie die Vorhersage der Über- oder Unterwässerung basierend auf der geplanten Gewichtsabnahme durch Ultrafiltration, der Trinkmenge während der Behandlung, des Rinseback-Volumens und von Rest-Diurese-Daten vorgenommen wird und/oder wobei die Vorhersage der Clearance großer Moleküle basierend auf der Harnstoff-Clearance vorgenommen wird und/oder wobei die Vorhersage der erlaubten Salzaufnahme basierend auf der durch Ultrafiltration sowie ...

Total chlorine water detection system and method for medical fluid treatments

A renal therapy system is described. The system comprises: a water treatment machine 50 producing an at least partially purified water sample; a dialysis machine 100 for providing dialysis therapy to a patient, the dialysis machine receiving the water sample from the water treatment machine; and a chlorine detection component 10 configured to determine an amount of total chlorine in the water sample by (i) generating tri-iodide from the water sample by application of a voltage thereto, and (ii) monitoring a current associated with the amount of tri­-iodide. First and second chambers 24, 26 may be in contact with an iodide reservoir 12 and a reducing agent reservoir 14 respectively. A first electrode pair 42a, 42b may be in electrical contact with both the first and second chamber, and a second electrode pair 32a, 32b may be in contact with the first chamber only.

Clamping mechanism for dialysis tubing

A clamping mechanism for dialysis tubing comprises a clamp and a pin 4. The pin 4 has a hole 5 for the tubing to pass through. It has an enlarged central portion 2 and a narrow portion 3. The clamp also has hole 10 for the tubing to pass through. The point 1 of the pin 4 passes through recesses 11 and 12 in the clamp. When the enlarged portion 2 is positioned in recess 12, the tubing is unclamped. Should a needle attached to the tubing disconnect from a patient, the pin 4 will slide into the clamp, once the pin travels more than a certain distance, the narrow portion 3 of the pin 4 will engage recess 12, causing jaws 6 to clamp the tubing, thus stopping the blood flow, in this case the venous blood flow. The jaws 6 can be opened and the pin 4 reset by pressing arms 9. The clamp has means 8 to attach the clamp to a patient.

Dialysis machine with valve clamp arrangement

Pre-assembled medical fluid flow system and method of making same

PUMP FOR PUMPING LIQUID

Flow balancing devices, methods, and systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Device and method for solubilizing, separating, removing and reacting carboxylic acids in oils, fats, aqueous or organic solutions by means of micro-ornanoemulsification

Device and method for solubilizing, separating, removing and reacting carboxylic acids in oils, fats, aqueous or organic solutions by means of micro- or nanoemulsification

DEVICE FOR THE SUPPLY A EXTRAKORPORALEN OF A BLUTKREISLAUFS

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

PROCEDURE FOR THE PREPARATION OF A TREATMENT MACHINE AND TREATMENT MACHINE

HOSE CLIP FOR MEDICAL APPLICATIONS

VALVE MECHANISM F�R OF INFUSION FLUID SYSTEMS

ANTITHROMBOTI BLOOD TREATMENT SYSTEM.

DEVICE FOR THE CALCULATION OF THE DIALYSIS EFFICIENCY

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

Portable dialysis machine

H:\mhiutewovn\N~orbf\CC\MH56030_Lducx-1/03j2(08 The specification discloses a portable dialysis machine having a detachable controller unit and base unit. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a planar surface for receiving a container of fluid, a scale integrated with the planar surface, a heater in thermal communication with the planar surface, and a sodium sensor in electromagnetic communication with the planar surface. Embodiments of the disclosed portable dialysis system have improved structural and functional features, including improved modularity, ease of use, and safety features. WO 2012/108910 PCT/US2011/053184 201 211 210 ...

Container for fluids and apparatus for temperature control, e.g. warming, of medical fluids

A container for warming fluids, the container comprising an inlet port, an outlet port, and a fluid conduit configured for putting the inlet port in fluid communication with the outlet port and comprising one or more deflection sections. The fluid conduit has a non-constant maximum width in a direction of fluid flow through the fluid conduit. At least one of the one or more deflection sections further comprises an entry section and an exit section, each respective exit section being arranged downstream, in the direction of fluid flow, from each respective entry section. The maximum width of the fluid conduit decreases along the direction of fluid flow through the entry section over a first distance and the maximum width of the fluid conduit increases along the direction of fluid flow through the exit section over a second distance, the first distance and the second distance being different from one another. An apparatus for warming medical fluids including the container and an extracorporeal ...

CONTROL OF A WATER DEVICE VIA A DIALYSIS MACHINE USER INTERFACE

A home medical device system includes a home therapy machine for performing a home therapy on a patient; a user interface operably connected to the home therapy machine, the user interface receiving operator inputs; a water treatment device in fluid communication with the home therapy machine; and a data connection between the home therapy machine and the water treatment device, wherein the home therapy machine transmits data via the connection to the water treatment device for control of the water treatment device, the data provided based on at least one of the operator inputs received via the user interface.

Generator involving the use of a single blood pump

Vapour-sterilisable blood separating device

The invention relates to a device (1) for separating blood into individual components and/or groups of components, in the form of a sterilisable system comprising a filter arrangement (2), which forms an inlet chamber (4) and an outlet chamber (5) by means of filter elements (3) which are arranged therein, a receptacle (6) for cellular blood components and a receptacle (7) for blood plasma. The inlet chamber (4) of the filter arrangement (2) can be connected to the blood source (10) via a line on the inlet side to conduct the blood and is connected, on the outlet side, to the receptacle (6) for cellular components of the blood. The outlet chamber (5) is connected to the receptacle (7) for blood plasma via a line on the outlet side. The aim of the invention is to use thermal sterilisation, in particular vapour sterilisation, in order to sterilise said device. Said aim is achieved by virtue of the fact that a respective line (17, 20) opens into the inlet-side line (14) of the inlet chamber ...

Blood processing device using extra-corporeal circulation and automatic spent fluid drainage

Container filled with a liquid concentrate for making dialysate

Method for filling and rinsing a set of blood lines

The invention relates to a method for filling and rinsing a set of blood lines, comprising a pump segment for a blood pump, an arterial line connected to an input of a dialysis machine and a venous line connected to the output of a dialysis machine, by means of a substitute line. Said method comprises the steps of connecting the arterial line to the venous line and connecting both lines to a rinse port, connecting the substitute line to a substitute port, opening the rinse port, filling the arterial and venous line, rinsing the arterial and venous line, closing the rinse port, circulating the substitute in the circuit of arterial line, dialysis machine, and venous line by means of the blood pump, characterised in that the filling and/or rinsing of the venous and the arterial line occurs simultaneously wherein substitute is introduced from the substitute line. The invention further relates to a set of blood lines.

Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams

Medical tube

Device and method for treating a medical fluid and medical cassette

Urinary biomarkers for predicting long-term dialysis

Systems, methods, and devices relating to a biomimetic cellularized nephron unit

Disclosed herein are systems and devices for culturing cells in a biomimetic environment of a cellularized nephron unit, and methods for fabricating and using the cellularized nephron unit.

Hemodial ysis system

A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly.

Hemodial ysis system

A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly.

Treating infections with ceftolozane/tazobactam in subjects having impaired renal function

Disclosed are methods of administering cephalosporin/tazobactam to human patients with end stage renal disease undergoing hemodialysis and suffering from a complicated intra-abdominal infection or a complicated urinary tract infection.

Treating Infections with Ceftolozane/Tazobactam in Subjects Having Impaired Renal Function

Disclosed are methods of administering cephalosporin/tazobactam to human patients with end stage renal disease undergoing hemodialysis and suffering from a complicated intra abdominal infection or a complicated urinary tract infection.

Method for treating dialysate, dialysis system, and method for pre-evaluating dialysis patients for treatment with same

A method for treating dialysate solutions used in dialysis wherein dialysate is treated in an early part of a dialysis treatment session by external infusion of bicarbonate solution into the dialysate circuit to eliminate the need for bicarbonate requirements in concentrates used for preparation of precursor dialysate (priming) solutions and/or for a solid bicarbonate layer in a sorbent cartridge. Dialysate is treated in a latter part of a dialysis treatment session by introduction of sterile dilution water to reduce sodium concentration in the dialysate. The method provides a more efficient and reduced use of dialysate fluids, electrolytes, sorbent cartridge materials, equipment scale, or any combinations of these, while maintaining purity standards and applicable physiological ranges for bicarbonate, sodium, and other dialysate solution components over the course of a dialysis treatment session.

A medical cassette and an apparatus and a method for treating a medical liquid and a medical cassette

Abstract The invention relates to a device for treating a medical fluid, said device comprising a treatment machine with a coupling surface, to which a cassette consisting of a hard 5 part with fluid-conducting channels that are covered by a flexible film can be coupled. The invention also relates to a corresponding medical cassette. According to the invention, to guarantee that the film of the cassette can be coupled to the treatment machine without the inclusion of air, air can be sucked off along the plane lying between the flexible film and the coupling surface during the coupling process and/or 10 when the cassette is coupled to the machine. The invention also relates to a method for coupling the cassette and to a method for checking the leak-tightness of the cassette by means of the regulation of the air removal by suction.

Home medical device systems and methods for therapy prescription and tracking, servicing and inventory

BLOOD TREATMENT SYSTEMS AND METHODS

A dialysis system, comprising: a chamber including a membrane that is movable in the chamber and that fluidly separates a first portion of the chamber from a second portion of the chamber, the chamber including a first inlet to the first portion and a second inlet to the second portion; and a blood leak sensor associated with the chamber and arranged to detect blood in the first portion of the chamber, wherein the blood leak sensor is arranged to measure a first level in the first portion and a second level in the second portion for comparison of the first and second levels to each other to determine whether blood is present in the first portion.

A medical cassette and an apparatus and a method for treating a medical liquid and a medical cassette

Abstract The invention relates to a device for treating a medical fluid, said device comprising a treatment machine with a coupling surface, to which a cassette consisting of a hard 5 part with fluid-conducting channels that are covered by a flexible film can be coupled. The invention also relates to a corresponding medical cassette. According to the invention, to guarantee that the film of the cassette can be coupled to the treatment machine without the inclusion of air, air can be sucked off along the plane lying between the flexible film and the coupling surface during the coupling process and/or 10 when the cassette is coupled to the machine. The invention also relates to a method for coupling the cassette and to a method for checking the leak-tightness of the cassette by means of the regulation of the air removal by suction.

Detecting pressure pulses in a blood processing apparatus

A monitoring device (7) operates on a pressure signal from a blood processing apparatus, e.g. a dialysis machine, which has an extracorporeal blood circuit connected to a vascular system of a subject for pumping blood through a dialyzer, and a treatment fluid supply system for pumping a treatment fluid through the dialyzer. The monitoring device (7) has a first input block (50) for obtaining a first pressure signal (y) from a first pressure sensor (6a) in the extracorporeal blood circuit, and a second input block (51) for obtaining a second pressure signal (w) from a second pressure sensor (6b) in the treatment fluid supply system. An emulation block (56) generates, as a function of the second pressure signal (w), an emulated first pressure signal (y) which emulates a concurrent signal response of the first pressure sensor (6a), and a filtering block (53) generates a filtered signal (y) as a function of the first pressure signal (y) and the emulated first pressure signal (y), so as to suppress ...

Connector with seal element and adapted connector parts

The invention relates to a connector comprising at least one first connector part and at least one second connector part. The connector parts can be connected to one another in a fluid-tight manner and can be locked to one another via at least one closure element. One of the connector parts has at least one openable seal element which blocks a flow in the closed state, in particular a septum or a seal disk, and the other connector part has at least one opening element for opening the seal element. One of the connector parts has at least one protrusion, and the other connector part has at least one receiving area, the opening element and the seal element being arranged relative to each other such that the opening element opens the seal element only when the protrusion is inserted into the receiving area.

Remote controlled medical apparatus

Abstract The invention relates to remote controlled blood cleaning of a patient. A dialysis unit treats the patient's blood in accordance with a prescribed therapy. The dialysis unit has a bi-directional wireless interface towards a 5 gateway unit, which is further connected to a remote host via at least one interconnecting network. Data representing at least one executed treatment of a patient is stored in the dialysis unit and is transmitted to the remote host via the gateway unit. The remote host transmits control data to the dialysis unit, the control data influencing the prescribed therapy 10 being, or to be, executed by the dialysis unit. (Fig. 1) 140\ 100 115 DbP Dr dh Dbp D 125 127 Dbp De 13 Dtrdh Dm.10W 112 130 %c 120 D %K Fig. 1 R c d210 Transmit control data from remote host + -220 Receive -control data in gateway unjit Transmit control data from gateway /230 unit over wireless interface Receive control data in dialysis unit Adapt prescribed therapy in 250 response to the control ...

Configuring a user interface of a dialysis machine

In one aspect, a dialysis system includes one or more tubes for transporting fluid to and from a dialysis patient, a display and one or more processors. The one or more processors are configured to determine an identity of a user of the dialysis system. Based on the determined identity of the user, the one or more processors access a user interface configuration profile associated with the user, and cause a user interface to appear on the display. The user interface includes one or more controls that, when invoked, cause the dialysis system to carry out a dialysis operation. The user interface is caused to appear on the display based at least in part on the identity of the user.

System and method for cardiac dialysis

A system and method for treating a patient may include implanting an apparatus that includes a tube housing a one-way valve and having first and second surfaces. When the apparatus is implanted, the first surface is located inside the right atrium of the patient and the second surface is located on the skin of the patient. When implanted, the apparatus is used for drawing blood from the right atrium and/or providing a liquid to the patient. The apparatus may be designed to be hermetically sealed when disconnected from input and output lines.

PERSONAL HEMODIALYSIS SYSTEM

A dialysis machine includes a dialysis instrument having a pump actuator and first and second valve actuators, and a disposable cassette operable with the dialysis instrument, the disposable cassette including a pump portion operable with the pump actuator, first and second valve chambers operable with the first and second valve actuators, the first and second valve chambers communicating fluidly with each other, at least the first valve chamber communicating fluidly with a compliance chamber, the compliance chamber negating a first backpressure due to a pneumatic closing pressure used to close the first valve chamber to help to ensure the pneumatic pressure applied to the first valve chamber will close the first valve chamber against a second backpressure from an existing closure of the second valve chamber.

ADMINISTRATION AND MONITORING OF NITRIC OXIDE IN EX VIVO FLUIDS

Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. The systems and methods described herein provide for administering nitric oxide to the fluid, monitoring nitric oxide or a nitric oxide marker in the fluid, and adjusting the nitric oxide administration.

TUBE CLAMP DEVICE AND TUBE CONNECTION DEVICE

A tube clamp device and a tube connection device having high durability and allowing an increase in operability when an operator locks these devices. The tube connection device comprises a first clamp and a second clamp holding and pressing two flexible tubes (8, 9). The tubes are placed on the lower jaw part of the second clamp and pressed by a pressing force applied thereto in the direction of arrow F until the tubes are formed in a flat shape. A hook part (310) having a hook portion divided into multiple pieces is installed on the upper jaw part of the second clamp, and the hook portion B (312) is formed of a POM elastic member having, on one side thereof, a projected part (314) projected from the other adjacent hook portion. When a pressing force is applied to the upper jaw part, the hook portion B (312) projected from the other adjacent hook portion is elastically deformed and engaged with a POM roller B (317) to prevent the return of the hook part (310).

CALCULATION OF THE PATIENT FLUID REMOVAL RATE TO COMPENSATE FOR THE VOLUME OF FLUID NOT REMOVED BECAUSE OF MACHINE DOWN TIMES

A patient fluid removal compensation volume may be determined to make up for the patient fluid removal that does not occur during machine down times, and the patient fluid removal rate may be increased until the compensating volume is satisfied.

SYSTEM AND METHOD FOR CARDIAC DIALYSIS

A system and method for treating a patient may include implanting an apparatus that includes a tube housing a one-way valve and having first and second surfaces. When the apparatus is implanted, the first surface is located inside the right atrium of the patient and the second surface is located on the skin of the patient. When implanted, the apparatus is used for drawing blood from the right atrium and/or providing a liquid to the patient. The apparatus may be designed to be hermetically sealed when disconnected from input and output lines.

PUMP CASSETTE AND METHODS FOR USE IN MEDICAL TREATMENT SYSTEM USING A PLURALITY OF FLUID LINES

FIBER-OPTIC CLOT DETECTOR WITH AN ULTRASONIC CLOT NEUTRALIZER

A method and system for detecting and neutralizing blood clots during dialysis (e.g., hemodialysis) is provided. A fiber-optic sensor is provided in a hemodialysis machine to detect vibration of blood cells, and the hemodialysis machine can be configured to prevent blood clotting by sounding an alarm, agitating the blood cells, infusing saline, raising temperature and/or infusing heparin.

SYSTEM AND METHOD FOR PERFORMING ALTERNATIVE AND SEQUENTIAL BLOOD AND PERITONEAL DIALYSIS MODALITIES

A dialysis system comprises a dialysis fluid pump, a dialysis fluid line, a blood filter in fluid communication with the dialysis fluid pump via the dialysis fluid line, an extracorporeal circuit connectable to a patient, a blood pump in fluid communication with the blood filter via the extracorporeal circuit, and a control unit programmed to (i) in a first treatment, prepare peritoneal dialysis treatment fluid by combining purified water with a peritoneal dialysis concentrate using the dialysis fluid pump and the dialysis fluid line, and (ii) in a second treatment, prepare hemodialysis treatment fluid by combining purified water with a blood treatment concentrate using the dialysis fluid pump and the dialysis fluid line.

PORTABLE DIALYSIS MACHINE

APPARATUS AND METHOD FOR CHANGING BODY TEMPERATURE BY EXTRACORPOREAL HEATING OR COOLING OF BLOOD

An apparatus for rapidly cooling or heating the body temperature of a patient comprising a housing having a blood inlet and outlet, a pump, a heat exchanger portion associated with the housing for selectively heating or cooling the blood, and a blood conduit in fluid communication with the blood outlet of the pump portion, the blood conduit being in direct thermal contact with the heat exchanger portion. The heat exchanger portion comprises a Peltier cell having one or more thermoelectric modules contained between a pair of ceramic substrates, and a heat sink in thermal contact with the one or more thermoelectric modules for removing heat from the one or more thermoelectric modules.

APPARATUS AND METHOD FOR CONTROLLING FLUID FLOW

Apparatuses for flowing multiple fluids in a single channel while substantially maintaining fluid separation are disclosed. In one configuration, the apparatus includes a first internal surface portion with an affinity to a first fluid and a second internal surface portion with an affinity to a second fluid. In another configuration, the apparatus includes a first fluid channel portion, a second fluid channel portion wrapped helically around the first fluid channel portion, and an opening therebetween. Also disclosed is an apparatus for maintaining substantially even fluid flow in fluid pathways having a first flow resistor portion, a second flow resistor portion, and a fluid channel therebetween.

REMOTE CONTROLLED MEDICAL APPARATUS

The invention relates to remote controlled blood cleaning of a patient (P). A dialysis unit (110) treats the patient's (P) blood in accordance with a prescribed therapy. The dialysis unit (110) has a bi-directional wireless interface (110W-120W) towards a gateway unit (120), which is further connected (125) to a remote host (140) via at least one interconnecting network (130). Thus, therapy related parameters (Dbp, Dr, dh, Dw) can be transmitted from the dialysis unit (110) to the remote host (140). It is also rendered possible for the remote host (140) to transmit control data (Dctrl) to the dialysis unit (110), the control data (Dctrl) influencing the prescribed therapy being, or to be, executed by the dialysis unit (1 10).

BLOOD DIALYZER

A hemodialysis apparatus that carries out hemodialysis treatment by measuring or calculating the blood volume or its volume change as a blood indication level, and by controlling dialysis conditions according to said target blood indication level, wherein the chronological course of said blood indication level is defined as a target control line, and the primary blood volume (BV0) can be calculated as blood indication level. In the former part of the dialysis operation, the water removal is controlled so that the circulating blood volume in the body approach to the standard blood volume (BV st) with the use of said target control line. After the water removal of the former part of the dialysis operation, when the circulating blood volume in the body attains the standard blood volume (BV st), the latter part of the dialysis operation is started. In said latter part of the dialysis operation, the water removal operation is performed by substantively maintaining said standard blood volume ...

APPARATUS WITH ACTIVES FROM TISSUE

An apparatus for cleansing wounds in which irrigant fluid containing one or more physiologically active components from a means for supplying physiologically active agents from cells or tissue to the wound, e.g. an irrigant reservoir connected to a container that contains a cell or tissue component, in turn connected to a supply tube, connected to a conformable wound dressing and wound exudate from the dressing are moved by a device (which may be a single pump or two or more pumps) for moving fluid through a flow path which passes through the dressing and a means for providing simultaneous aspiration and irrigation of the wound. The latter removes materials deleterious to wound healing, while distributing materials that ar e beneficial in promoting wound healing from cells or tissue and the physiologically active components in therapeutically active amounts in a precise and time-controlled manner over the wound bed.

BLOOD FILTER DEVICE AND METHOD OF MANUFACTURING THE SAME

A blood filter device which includes: a housing having a dome (2) with an inlet, a filter retaining portion (3) positioned below the dome, and a bottom portion (4) with an outlet; and a filter (8) mounted in the filter retaining portion. A filter sheet (8a) forms pleats, and ridgelines of the respective pleats traverse the filter retaining portion. The device further includes an annular holder (9) intervening between the filter retaining portion and the filter, an annular rib substrate (10) disposed facing the ridgelines of the pleats and having ribs inserted respectively between the pleats; and a bonding resin (11) supplied into outer periphery of the filter including the annular holder and the annular rib substrate, bonding the outer periphery of the filter to the filter retaining portion. Gaps are ensured between the pleats of the filter, enabling air bubbles to be removed easily.

CONNECTOR

The invention relates to a connector comprising at least one first connector part and at least one second connector part. The connector parts can be connected to one another in a fluid-tight manner and can be locked to one another via at least one closure element. One of the connector parts has at least one openable seal element which blocks a flow in the closed state, in particular a septum or a seal disk, and the other connector part has at least one opening element for opening the seal element. One of the connector parts has at least one protrusion, and the other connector part has at least one receiving area, the opening element and the seal element being arranged relative to each other such that the opening element opens the seal element only when the protrusion is inserted into the receiving area.

PACKAGING OF POWDERY MATERIAL FOR PREPARATION OF A MEDICAL SOLUTION

A package (1) is configured to store a powdery material (2) which is to be mixed with a solvent to form a medical solution, such as a dialysis solution. The package (1) comprises a filled cavity portion (6a) containing the powdery material (2), optionally separated into groups of different composition, and a tab portion (9) integrally formed with the filled cavity portion (6a) and being swept around the filled cavity portion (6a) so as to define a roll-up package. The tab portion (9) forms a protective barrier that shields the powdery material (2), e.g. by counteracting transport of moisture into and out of the package. The tab portion (9) may also stabilize the package. The roll-up package is compact, and simple to manufacture and handle.

ADMINISTRATION AND MONITORING OF NITRIC OXIDE IN EX VIVO FLUIDS

Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. The systems and methods described herein provide for administering nitric oxide to the fluid, monitoring nitric oxide or a nitric oxide marker in the fluid, and adjusting the nitric oxide administration.

FLOW THROUGH HEATER

An electrical heating device comprises a body; an insulating material disposed proximate the body, the insulating material being in the form of a base layer dielectric; a heater disposed proximate the insulating material; a top dielectric layer disposed proximate the heater, the top dielectric layer and the insulating material cooperating to encapsulate the heater; and a protection housing surrounding the heater, the top dielectric layer, and the insulating material.

APPARATUS AND METHODS FOR CONCENTRATION DETERMINATION USING POLORIZED LIGHT

Methods and apparatus for concentration determination using polarized light. The apparatus includes a first polarized light source having a first light source polarization axis and a second polarized light source having a second light source polarization axis generally perpendicular to the first light source polarization axis. Also, a first polarized light receiver having a first polarized light receiver polarization axis and configured to measure an intensity of light transmitted from the first light receiver polarizer and a second polarized light receiver having a second polarized light receiver polarization axis substantially perpendicular to the first light receiver polarization axis and configured to measure an intensity of light transmitted from the second light receiver polarizer, wherein the first and second light receiver polarization axes are generally +/- 45 degrees relative to the first and second light source polarization axes.

Medical device and methods of monitoring a patient with renal dysfunction

Embodiments relate to a method of monitoring physiological parameters of a patient with renal dysfunction. The method includes electrically connecting one or more medical device electrodes with a measurement site of a patient, generating one or more first stimulation signals sufficient to provide input physiological parameters specific to the patient, measuring one or more first bioimpedance values from the generated signals, analyzing at least one of the input physiological parameters within the one or more first bioimpedance values and generating a personalized dialysis program. The systems and methods can further provide essentially real-time data of patient undergoing treatment and control of treatment to a patient.

Cassette system integrated apparatus

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

Acoustic access disconnection systems and methods

An access disconnection system includes a blood treatment machine including a housing, an access site detection housing separate from the blood treatment machine housing, a transmitter positioned in the access site housing and configured to transmit an ultrasound wave into a blood stream of a patient, a receiver positioned in the access site housing and configured to receive a reflection of the ultrasound wave from the blood stream of the patient; and electronic circuitry in communication with the transmitter and the receiver. The electronic circuitry is supported by the access site detection housing, and the transmitter is configured to send a wireless disconnection output to the blood treatment machine. The disconnection output is indicative of a change in the reflected ultrasound wave received by the receiver sufficient to expect that an access disconnection of one of the arterial line and the venous line has occurred.

Modular Extracorporeal Systems and Methods for Treating Blood-Borne Diseases

Extracorporeal systems and methods for treating blood-borne diseases in a subject or for developing drugs to treat blood-borne diseases include various environmental and treatment modules that can be tailored to a specific disease or infection. In certain embodiments of the systems and methods, a blood sample is treated with hydrostatic pressure, a pulsed electrical field, a pharmaceutical agent, microwave, centrifugation, sonification, radiation, or a combination thereof, under environmental conditions that are effective for the treatment.

Method and apparatus for machine error detection by combining multiple sensor inputs

One of the most significant safety concerns in the automation of extracorporeal blood treatments such as dialysis is the risk of blood leakage. Extracorporeal blood treatment systems draw blood at such a high rate that a loss of integrity in the blood circuit can be serious. There are a number of mechanisms for detecting and preventing leaks, but none is perfect. This tends to limit the use of such equipment in unsupervised settings, such as the home will be limited. Some leak detection schemes can be made sensitive enough to detect the barest of leaks, but when this is done, they result in too many false positives. The invention combines information from multiple inputs to enhance sensitivity in leak detection and reduce the problem of false positives.

Medical appliance

This invention relates to a medical appliance, in particular an apparatus for the extracorporeal blood treatment, with a housing including a door and with a handle mechanism arranged at the door, by means of which the door can be locked with the housing via a locking mechanism, wherein a part of the locking mechanism is formed at the handle mechanism in its part protruding into the housing and wherein a form-fit unit is provided which includes at least one form-fit means and at least one form-fit means counterpart, wherein on locking and/or closing the door the at least one form-fit means at least partly engages in the at least one form-fit means counterpart.

Non-invasive radio frequency liquid level and volume detection system using phase shift

A medical fluid system includes a medical fluid pump; a container holding a fluid to be pumped by the medical fluid pump, the fluid at a first time having a first conductivity, the fluid at a second time having a second conductivity; and a radio frequency level sensor positioned in operable relation with the container, the radio frequency operation of the level sensor configured so as to be (i) indicative of a level of the fluid in the container and (ii) at least substantially independent of whether the fluid has the first conductivity or the second conductivity. The medical fluid system can determine the level of medical fluid by measuring the resistance, impedance or phase shift seen by the sensor.

Medical fluid pumping systems and related devices and methods

This disclosure relates to medical fluid pumping systems and related devices and methods. In some aspects, a medical fluid pumping system includes a medical fluid pumping machine including a piston head that can be linearly displaced and a medical fluid cassette that can be secured to the medical fluid pumping machine. The medical fluid cassette includes a fastening member attached to a region of a flexible membrane overlying a fluid pump chamber, and the piston head is configured to be mechanically connected to the fastening member of the cassette.

Medical fluid autoconnection and autoidentification method

A medical fluid autoconnection method includes: enabling acceptance a pierceable connector that is capable of fluidly communicating with a source of medical fluid into a moveable holder; temporarily fixing a spike to a medical fluid pumping machine; automatically detecting whether the pierceable connector has been placed into the moveable holder; if the pierceable connector is sensed as being placed in the moveable holder, moving the holder so that the spike pierces the pierceable connector; and enabling medical fluid to be pumped from the source through the connected spiked and connector.

Multimodal dialysis system

A dialysis device for operation in multiple modes and for maintaining a known gradient of potassium ion or other electrolyte between the blood of a patient and a dialysate fluid is described. The dialysis device is capable of being used for hemodialysis or peritoneal dialysis, and the dialysis device is capable of operation with a dialysate purification unit outside of a clinical setting or with a supply of water that can be supplied in a clinical setting. The dialysis device has a composition sensor containing a potassium-sensitive electrode for measuring a potassium ion concentration in one or more of the patient's blood and the dialysate fluid and an infusate pump operated to adjust a potassium ion concentration in the dialysate fluid based at least in part on data from the composition sensor.

Filtration system for preparation of fluids for medical applications

Systems, methods, and devices for preparation of water for various uses including blood treatment are described. In embodiments, fluid is passed either by pump or passively by gravity feed, through various filtration elements from a fluid source to a treatment fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment which provides multiple benefits and liabilities to overcome, as discussed herein. Mechanisms for preparing pure water for infusion or medicaments are described such as elimination of chlorine and colloidal aluminum. Also various control mechanisms to help avoid contamination are describe.

Cassette system integrated apparatus

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

Blood treatment systems and methods

Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid, may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

CASSETTE WITH A SENSOR FOR DETERMINING THE DIFFERENCE BETWEEN A FIRST AND A SECOND FLUID STREAM

The invention relates to the balancing of fluid streams in a dialysis system. In particular the invention relates to a cassette for conveying a first and a second fluid stream in a dialysis system, wherein the first and the second fluid streams can be medical fluid streams such as for example dialysate streams or blood streams, wherein the cassette has a sensor as a device for balancing the first and the second fluid stream, and wherein the sensor has a first channel for the first fluid stream and a second channel for the second fluid stream. The invention further relates to a dialysis system, which is configured to accommodate at least one cassette which is configured as described above. Furthermore, the present invention relates to an arrangement by which two channels for the first and the second fluid streams are formed. In addition, the invention relates to a method for construction of the two channels or the arrangement. 1. Cassette with a first and a second fluid stream in a dialysis system , wherein the cassette has a sensor as a device for determining a difference between the first and the second fluid stream and wherein the sensor has a first channel for the first fluid stream and a second channel for the second fluid stream.2. Cassette according to claim 1 , wherein the first and the second fluid streams are dialysate streams or blood streams.3. Cassette according to claim 1 , wherein:the first and the second channel are disposed substantially parallel to each other; andthe sensor is configured to expose the first and the second channel to a magnetic field for determining the difference between the first and the second fluid streams, wherein the magnetic field is aligned substantially perpendicular to the first and to the second channel.4. Cassette according to claim 3 , wherein:due to the magnetic field a separation of positive and negative charge carriers occurs in the first fluid stream of the first channel and in the second fluid stream of the second ...

Apparatus and Kit For Encapsulating At Least One Compound For Therapeutic and/or Diagnostic Use in Erythrocytes

A portable and highly automated apparatus and method for introducing at least one compound within erythrocytes; the apparatus comprises a reusable part provided with mechanical elements such as pumps and valves and electronic units such as a control unit; the apparatus also comprises a disposable part, which is adapted to come into contact with the sample containing the erythrocytes and is provided with a system of tubes made of deformable material, a plurality of reservoirs and one or more filters; the apparatus allows a further concentration of the erythrocytes after they have been treated; the apparatus allows to introduce the compound in the erythrocytes in a virtually totally automated manner. 112910314567689101161213. An apparatus for introducing at least one compound within erythrocytes; the apparatus () comprises a system () of connection channels , which includes a first and a second channel ( , ); an introducing unit () for inserting a sample containing the erythrocytes within the apparatus (); a separating unit () for separating the different components of the sample from one another; a combining unit () , which comprises a first reservoir () and in the area of which the erythrocytes and the compound are combined together so as to obtain treated erythrocytes; an inlet () for inserting the compound in the first reservoir (); a feeding unit () , for feeding a first solution through the first channel () and feeding a second solution through the second channel (); a concentrating unit () for concentrating the content of the first reservoir (); and a collecting unit () , which comprises a second reservoir () for collecting treated erythrocytes;{'b': 2', '3', '4', '5', '8', '11', '12, 'the system () of channels connecting the introducing unit (), the separating unit (), the combining unit (), the feeding unit (), the concentrating unit () and the collecting unit ();'}{'b': 1', '15', '49', '15', '3', '4', '5', '12, 'the apparatus () being characterised by ...

DETECTION DEVICE AND METHOD

Detection device for quantitative detection of predetermined molecules, in particular medium size protein molecules, in a sample liquid with a light source for emitting measurement radiation, a section for irradiating the sample liquid and a light detector for measuring the detection radiation exiting the section for irradiating the sample liquid, as well as an analysis stage located downstream of the light detector for analyzing the detector signal, wherein the light source is designed such that the measurement radiation has a spectral range exciting the intrinsic fluorescence of a molecule to be determined, and the light detector is designed such that at least one spectral range of the detection radiation is measured, in which the molecule emits intrinsic fluorescence radiation. 111-. (canceled)12. A detection device for quantitative detection of predetermined molecules , in particular medium-sized protein molecules , in a sample liquid with a light source for emitting measurement radiation , a section for irradiating the sample liquid and a light detector for measuring the detection radiation exiting the section for irradiating the sample liquid , as well as an analysis stage located downstream of the light detector for analyzing the detector signal , wherein the light source is designed such that the measurement radiation has a spectral range exciting the intrinsic fluorescence of a molecule to be determined , and the light detector is designed such that at least one spectral range of the detection radiation is measured , in which the molecule emits intrinsic fluorescence radiation.13. The detection device according to claim 12 , wherein the light source is a UV-radiation source emitting detection radiation exciting the intrinsic fluorescence of tryptophan claim 12 , in particular at 280 nm claim 12 , and the light detector is a photodiode or a photomultiplier claim 12 , which is sensitive in a spectral range claim 12 , in which intrinsic fluorescence radiation ...

VASCULAR ACCESS DEVICE FOR HEMODIALYSIS

Single needle vascular access systems, devices and methods for use in hemodialysis and apheresis procedures. A single needle vascular access device includes a body having an upper and lower passage with both in fluid communication with a vascular dilator. A cannulation needle is guided through the lower passage and vascular dilator to cannulate a graft or fistula. Following cannulation, the dilator is gently introduced into the vessel. The cannulation needle is removed, and a venous tube is introduced through the upper passageway through the vascular dilator and into the fistula or graft. Blood is then removed from the body through the vascular dilator side orifices and returned through the venous line. Depending on the clinical situation, the vascular dilator can be used with one or both needles of a conventional two needle system. In the later case, the vascular dilator may be connected to the dialysis tubes using conventional standard connectors. 1. A method for accessing a dialysis site comprising the steps of:a. cannulating a dialysis access site with a cannulation needle;b. advancing a vascular dilator over the cannulation needle;c. gently advancing the vascular dilator into the dialysis site into direct contact with the blood supply;d. removing the cannulation needle from the dialysis site; ande. connecting the vascular dilator to a dialysis line to provide blood to a blood dialysis unit.2. A method to facilitate bi-directional flow during dialysis through a single access point comprising the steps of:a. positioning a vascular access device having a body with an upper passageway and a lower passageway;b. attaching a vascular dilator to the lower passageway at the front side of the body.c. initiating a cannulation by temporarily passing a cannulation needle through the vascular dilator using the lower passageway within the vascular access device;d. accessing a blood supply by cannulating a wall of a blood vessel with the cannulation needle;e. urging the ...

METHOD FOR POWERING PORTABLE DIALYSIS MACHINE

A method for operating a medical fluid machine, the method comprising: (i) if alternating current (“AC”) power is available, charging a battery, if needed, and powering the medical fluid machine with the AC power; and (ii) if AC power is not available (a) if fuel cell power is available, charging the battery, if needed, and powering the medical fluid machine with the fuel cell power; and (b) if fuel cell power is not available, powering the medical fluid machine using battery power until the AC power or fuel cell power is available. 1. A method for operating a medical fluid machine , the method comprising:(i) if alternating current (“AC”) power is available, charging a battery, if needed, and powering the medical fluid machine with the AC power; and (a) if fuel cell power is available, charging the battery, if needed, and powering the medical fluid machine with the fuel cell power; and', '(b) if fuel cell power is not available, powering the medical fluid machine using battery power until the AC power or fuel cell power is available., '(ii) if AC power is not available'}2. The method of claim 1 , wherein if fuel cell power is not available claim 1 , further powering a fuel cell using the battery power.3. The method of claim 1 , which includes sizing the medical fluid machine so as to be worn by a patient.4. The method of claim 1 , wherein the medical fluid machine is a peritoneal dialysis machine or a hemodialysis machine.5. The method of claim 1 , which includes converting the AC power to direct current (“DC”) power if the AC power is available claim 1 , charging the battery and powering the medical fluid machine using DC power created from the AC power.6. The method of claim 5 , which includes reducing power to a heating element if the heating element would receive more power than needed.7. The method of claim 1 , which includesgenerating electricity from the fuel cell power, the AC power or the battery power; andstoring the electricity for use with the medical ...

METHOD AND COMPOSITION FOR REMOVING UREMIC TOXINS IN DIALYSIS PROCESSES

A dialysis system comprising: a sorbent cartridge in fluid communication with at least one of a patient or a dialyzer, the sorbent cartridge including a housing having a zirconium phosphate layer followed by at least one of a urease layer, a zirconium oxide layer, or a carbon layer; a storage container in fluid communication with the sorbent cartridge; a pump in fluid communication sorbent cartridge and the storage container; and a control unit in operable communication with the pump, wherein the control unit is programmed to cause the pump to pump a dialysis fluid to flow (i) in a first direction through the sorbent cartridge, wherein the zirconium phosphate layer is contacted by the dialysis fluid before the at least one of the urease layer, zirconium oxide layer or carbon layer and (ii) in a second direction, reverse from the first direction, through the sorbent cartridge wherein the at least one of the urease layer, zirconium oxide layer or carbon layer is contacted by the dialysis fluid before the zirconium phosphate layer. 1. A dialysis system comprising:a sorbent cartridge in fluid communication with at least one of a patient or a dialyzer, the sorbent cartridge including a housing having a zirconium phosphate layer followed by at least one of a urease layer, a zirconium oxide layer, or a carbon layer;a storage container in fluid communication with the sorbent cartridge;a pump in fluid communication with the sorbent cartridge and the storage container; anda control unit in operable communication with the pump, wherein the control unit is programmed to cause the pump to pump a dialysis fluid to flow (i) in a first direction through the sorbent cartridge, wherein the zirconium phosphate layer is contacted by the dialysis fluid before the at least one of the urease layer, zirconium oxide layer or carbon layer and (ii) in a second direction, reverse from the first direction, through the sorbent cartridge wherein the at least one of the urease layer, zirconium ...

Apparatus for extracorporeal blood treatment

The invention describes an apparatus for extracorporeal blood treatment with a dialyzer which is separated by a semipermeable membrane in to a first and second chamber ( 29, 30 ), wherein the first chamber ( 29 ) is arrange in a dialysate pathway and the second chamber ( 30 ) is connectable to the blood circulation of a patient by means of a blood supply conduit ( 32 ) and a blood return conduit ( 31 ), an inlet ( 20 ) for fresh dialysate, an outlet ( 30 ) for spent dialysate, a measuring device ( 37 ) arranged in the outlet ( 36 ), wherein said measuring device ( 37 ) has at least one radiation source consisting of several light sources ( 1 ) for electromagnetic radiation. The invention is characterized in that the measuring device ( 37 ) is designed to generate substantially monochromatic electromagnetic radiation of different wavelengths, and to lead only one of these wavelength (at the same time) though the outlet ( 36 ) for spent dialysate, wherein at least one detector system ( 5 ) is provided for detection of the intensity or the absorption of the substantially monochromatic electromagnetic radiation passing through the outlet ( 36 ) for spent dialysate.

Tubing adapter for influencing the pressure inside a tubing section during a medical treatment

A tubing adapter for interconnection with a least one tubing section of a medical device, a dialysis fluid tubing system including such a tubing adapter, a medical device including such a dialysis fluid tubing system, and a method for avoiding a pressure within a dialysis fluid tubing system that is below a minimum pressure are described.

ELECTROSORPTION AND DECOMPOSITION DEVICE FOR THE PURIFICATION OF BLOOD AND OTHER FLUIDS

A device for the removal of toxic substances from biofluids has an electrocatalytic decomposition filter positioned between an inlet and an outlet. The filter includes a DC power source, a set of electrodes with a catalytic surface or in direct contact with sorbents offering catalytic activity, and an electrosorption filter for removing toxic substances. 1. A device for the removal of toxic substances from biofluid to provide a purified biofluid , the device comprising:i) a housing having an inlet for entry of the biofluid into said housing, an outlet for the removal of the purified biofluid and excess fluid from said housing, and a conduit connecting said inlet with said outlet;ii) an electrocatalytic decomposition filter for removing the toxin substances from the biofluid, said electrocatalytic decomposition filter being contained in said conduit such that said biofluid must pass through said electrocatalytic decomposition filter when flowing from said inlet to said outlet, said electrocatalytic decomposition filter comprising:a) a set of electrodes with an electro-catalytic surface for decomposition and gasification of the toxic substances via electro-oxidation, or a set of electrodes that are in direct electrical contact with porous materials that have been coated with electro-catalytic material;b) power source to provide the electrodes with an electrical charge in order to activate the electrocatalytic electrode surface; andc) an electronic control to switch the electrical charge on the electrodes in view of resorbing and release of the toxic substances and to prevent built-up of deposits on the electrodes; and [ 1) a nanostructured sorption material;', '2) a porous polymer matrix, wherein the pores in said matrix are of a size that allows the entry into said matrix of toxic substances sought to be removed from said biofluid and/or preventing the entry into said matrix of the biofluid; and', '3) a nanostructured sorption material captured in a porous polymer ...

CONCENTRATE FOR A DIALYSIS LIQUID AND DIALYSIS LIQUID MADE FROM IT

Concentrate for a dialysis liquid, at least comprising one acid and one physiologically acceptable electrolyte, characterized in that the acid comprises at least one acidic ion exchanger or is an acidic ion exchanger. 1. A concentrate for a dialysis liquid , comprising at least one acid and one physiologically acceptable electrolyte , characterized in that the acid comprises at least one acidic ion exchanger or is an acidic ion exchanger.2. The concentrate according to claim 1 , wherein the acidic ion exchanger comprises protonated and/or protonable groups selected from sulfonate groups claim 1 , sulfate groups claim 1 , phosphate groups claim 1 , phosphonate groups claim 1 , carboxylate groups claim 1 , and combinations of two or more thereof.3. The concentrate according to claim 1 , wherein the at least one physiologically acceptable electrolyte comprises cations selected from the cations of magnesium claim 1 , calcium claim 1 , potassium claim 1 , sodium claim 1 , or mixtures of two or more thereof; and comprises anions selected from chloride claim 1 , acetate claim 1 , lactate claim 1 , or two or more thereof.4. The concentrate according to claim 1 , wherein the concentrate comprises sodium chloride.5. The concentrate according to claim 1 , wherein the concentrate is provided as dry concentrate.6. The concentrate according to claim 1 , wherein the concentrate comprises at least one acidic ion exchanger claim 1 , a physiologically acceptable electrolyte and sodium chloride; wherein the acidic ion exchanger claim 1 , the physiologically acceptable electrolyte and sodium chloride are provided in combined form; or wherein the acidic ion exchanger and sodium are provided in combined form and the physiologically acceptable electrolyte separately from it; or wherein the acidic ion exchanger and the physiologically acceptable electrolyte are provided in combined form and sodium chloride separately from it; or wherein the acidic ion exchanger and the physiologically ...

Medical apparatus having a socket unit for connection of a device for supplying medical fluids, and device for supplying medical fluids having a plug unit for connection to a medical apparatus

A medical apparatus includes a socket unit for connection to a plug unit belonging to a device for supplying medical fluids for a blood treatment apparatus, the medical apparatus being in particular an extra-corporeal blood treatment apparatus such for example as an extra-corporeal dialysis apparatus or an apparatus for peritoneal dialysis, or an apparatus for filling the device for supplying medical fluids. A device for supplying medical fluids for a blood treatment apparatus, which has a plug unit for connection to a socket unit of a medical apparatus, is also described. The socket unit and the plug unit are characterised in that a safe and secure fluid-tight connection can easily be made with the two units between the device for supplying medical fluids and, on the one hand, the blood treatment apparatus or, on the other hand, the apparatus for filling the device for supplying medical fluids.

SUBCUTANEOUS VASCULAR ACCESS PORTS

Ports for accessing a vessels within a patient include passageways that can guide needles or other access devices directly into the vessels. The ports can be implanted subcutaneously within a patient. Some ports may be used in the creation and use of vascular access buttonholes. 1. A vascular access port comprising:a base that extends in a longitudinal direction and in a transverse direction, wherein the longitudinal direction of the base is configured to run substantially parallel to a lumen of a vessel when the vascular access port is attached to the vessel, and wherein the base comprises a bottom surface that is configured to face the vessel when the vascular access port is coupled to the vessel;an opening in the bottom surface of the base; anda passageway that extends through the base and comprises a proximal end and a distal end,wherein the proximal end of the passageway comprises an entry mouth that is configured to be positioned beneath a surface of the skin of a patient when the vascular access port has been implanted in the patient, wherein the entry mouth is open to permit one or more needles to be inserted individually through the passageway,wherein the distal end of the passageway comprises the opening in the bottom surface of the base, andwherein the passageway is configured to constrain the one or more needles inserted individually therethrough to pass through the opening and through a specific region of the vessel when the vascular access port is coupled to the vessel.2. The vascular access port of claim 1 , wherein the opening is elongated in the longitudinal direction so as to extend in the longitudinal direction to a greater extent than the opening extends in the lateral direction.3. The vascular access port of claim 2 , wherein the passageway is configured to constrain movement of the one or more needles inserted individually therethrough along a path that is both nonparallel and non-orthoganal to a longitudinal line along the bottom surface of ...

BATCH FILTRATION SYSTEM FOR PREPARATION OF STERILE FLUID FOR RENAL REPLACEMENT THERAPY

A first connector of a connector assembly of a sterile batch container can be unsealed. The connector assembly can be attached to a filling port of the sterile batch container and can have a sterile filter arranged between the filling port and the first connector. The first connector can be coupled so as to receive produced purified water. A transmembrane pressure can be monitored across the sterile filter while flowing the purified water through the connector assembly into the sterile batch container so as to provide a sterile fluid stored therein. The connector assembly can be detached from the filling port of the sterile batch container. After the detaching, the sterile batch container can be coupled to the blood treatment system. In response to a change in the transmembrane pressure exceeding a predefined level, an alarm signal can be generated. 1. (canceled)2. A device for preparing replacement fluid for an extracorporeal blood treatment , comprising:a replaceable fluid circuit including a sealed pre-sterilized replacement fluid container, which contains a replacement fluid concentrate, and a port that allows diluting water to be added to said replacement fluid concentrate by passing through said port; anda water treatment plant connectable to said replaceable fluid circuit for supplying water to the port, said water treatment plant having a permanent component including a metering pump and a replaceable module configured to decontaminate water provided to the plant from a source.3. The device according to claim 2 , wherein the replaceable filter module comprises a first stage filter for subjecting the water to a reduction/oxidation process to remove ions claim 2 , followed by an adsorption filter claim 2 , followed by stages of strong acid cation and strong base anion filters claim 2 , followed by a mixed bed deionization filter claim 2 , followed by a microtubular ultrafilter.4. The device according to claim 3 , further comprising a sensor detecting ion ...

METHOD, APPARATUS, AND SYSTEM FOR TREATMENT OF BLOOD OF A PATIENT

The present invention relates to a method for treating the blood of a patient, comprising removing water from the blood of patients at a settable water removal rate, wherein the position of the patient is determined and the water removal rate is set, controlled, and/or regulated depending on the determined position of the patient. The invention further relates to an apparatus for treating the blood of a patient, comprising a blood treatment device for removing water from the blood of the patient at a settable water removal rate, wherein position-determining means for determining the position of the patient, wherein the water removal rate is settable, regulatable, and/or controllable depending on the determined position of the patient. 223240424432240424446. The method according to claim 1 , wherein determining the position of the patient () is performed on a patient bed () claim 1 , on a patient chair and/or on to the patient () himself/herself claim 1 , preferably by the evaluation of sensors ( claim 1 , claim 1 , ) mounted to the patient bed () and/or to the patient chair claim 1 , of sensors arranged on the patient () claim 1 , and/or of sensors monitoring the patient () claim 1 , particularly by the evaluation of position sensors ( claim 1 , claim 1 , ) claim 1 , optical sensors claim 1 , and/or imaging sensors ().3. The method according to claim 1 , wherein removing water from the blood is performed by means of a peritoneal dialysis and the water removal rate is set claim 1 , controlled claim 1 , and/or regulated by means of setting claim 1 , controlling claim 1 , and/or regulating the concentration of substances dissolved in the dialysis fluid claim 1 , preferably of glucose and/or dextrin claim 1 , prior to introducing the dialysis fluid into the abdominal cavity.42. The method according to claim 3 , wherein the dialysis fluid located in the abdominal cavity is replaced for a dialysis fluid claim 3 , which has a different concentration of dissolved substances ...

PRESSURE MANIFOLD SYSTEM FOR DIALYSIS

A dialysis fluid pressure manifold system includes a plurality of pump and valve chambers controlling a flow of dialysis fluid; a header including a plurality of pneumatic passageways, each passageway in pneumatic communication with one of the pump or valve chambers; a plurality of electrically actuated pneumatic valves; and a plate defining a plurality of pneumatic apertures, each pneumatic aperture in pneumatic communication with one of the plurality of electrically actuated pneumatic valves, the plate providing the apertures each with an o-ring seal for airtight connection with the pneumatic passageways of the header. 1. A dialysis fluid pressure manifold system comprising:a plurality of pump and valve chambers controlling a flow of dialysis fluid;a header including a plurality of pneumatic passageways, each passageway in pneumatic communication with one of the pump or valve chambers;a plurality of electrically actuated pneumatic valves; anda plate defining a plurality of pneumatic apertures, each pneumatic aperture in pneumatic communication with one of the plurality of electrically actuated pneumatic valves, the plate providing the apertures each with an o-ring seal for airtight connection with the pneumatic passageways of the header.2. The dialysis fluid pressure manifold system of claim 1 , wherein the pump and valve chambers include pneumatically controlled flexible membranes.3. The dialysis fluid pressure manifold system of claim 1 , wherein the plurality of pneumatic passageways of the header are in pneumatic communication with the pump and valve chambers via pneumatic flow paths leading from the passageways to the pump and valve chambers.4. The dialysis fluid pressure manifold system of claim 3 , wherein the pneumatic flow paths are formed by pneumatic tubing.5. The dialysis fluid pressure manifold system of claim 1 , which includes at least one fastener for removably holding the header to the plate to compress each of the o-ring seals.6. The dialysis ...

Multimodal dialysis system

A dialysis device for operation in multiple modes and for maintaining a known gradient of potassium ion or other electrolyte between the blood of a patient and a dialysate fluid is described. The dialysis device is capable of being used for hemodialysis or peritoneal dialysis, and the dialysis device is capable of operation with a dialysate purification unit outside of a clinical setting or with a supply of water that can be supplied in a clinical setting. The dialysis device has a composition sensor containing a potassium-sensitive electrode for measuring a potassium ion concentration in one or more of the patient's blood and the dialysate fluid and an infusate pump operated to adjust a potassium ion concentration in the dialysate fluid based at least in part on data from the composition sensor.

METHOD AND DEVICE FOR SUPPLY OF A DIALYSIS UNIT WITH DIALYSIS FLUID

A method and a device for supply of a dialyser in a dialysis unit with dialysis fluid is disclosed. At least one dialysis fluid concentrate is mixed with water to produce the dialysis fluid. The dialysis fluid concentrate is prepared in a reservoir unit in a given amount. A control and arithmetic unit calculates the dialysis fluid rate (Qd) such that, after a given treatment time (T) has passed, a given residual amount of dialysis fluid concentrate or no residual amount remains in the reservoir unit. It is preferable to empty the reservoir unit by the end of treatment. 1. A method for supplying a dialyser of a dialysis unit with a dialysing fluid , the method comprising:making available at least one dialysing fluid concentrate in at least one receiving unit;making available water for diluting the at least one dialysing fluid concentrate;mixing the at least one dialysing fluid concentrate and the water in a first pre-set volumetric ratio to prepare the dialysing fluid; and{'sub': b', 'B', 'B, 'setting a dialysing fluid flow rate Qdover a pre-set treatment time Tat a value, which depends upon the presence of a pre-set volume of the at least one dialysing fluid concentrate at a commencement of a dialysis treatment time, the first pre-set volumetric ratio, and the pre-set treatment time Tduring the dialysis treatment, such that at the end of the dialysis treatment time the at least one receiving unit is either empty or contains a pre-set residual volume of the at least one dialysing fluid concentrate,'}wherein the at least one receiving unit contains only said at least one dialysing fluid concentrate.2. The method of claim 1 , further comprising:{'sub': b', 'B, 'determining the pre-set dialysing fluid flow rate Qdbefore the commencement of the dialysis treatment from the pre-set volume of the at least one dialysing fluid concentrate at the commencement of the dialysis treatment time, the first pre-set volumetric ratio, and the pre-set treatment time Tduring the dialysis ...

NOISE-REDUCING DIALYSIS SYSTEMS AND METHODS OF REDUCING NOISE IN DIALYSIS SYSTEMS

A method of pneumatically operating a dialysis system includes (i) pumping air in a first valve state from a pneumatic pump to operate a component of the dialysis system, and (ii) recirculating air in a second valve state by pumping air from an outlet of the pneumatic pump to an inlet of the pneumatic pump to minimize at least one of a noise pitch or noise amplitude when switching from the second valve state to the first valve state. 1. A method of pneumatically operating a dialysis system comprising:(i) pumping air in a first valve state from a pneumatic pump to operate a component of the dialysis system; and(ii) recirculating air in a second valve state by pumping air from an outlet of the pneumatic pump to an inlet of the pneumatic pump to minimize at least one of a noise pitch or noise amplitude when switching from the second valve state to the first valve state.2. The pneumatic method of claim 1 , which includes reducing air flow in the second valve state.3. The pneumatic method of claim 1 , which includes filtering air supplied to the pneumatic pump.4. The pneumatic method of claim 1 , wherein pumping air includes pumping positive air pressure claim 1 , and which includes locating a valve for producing the first and second valve states pneumatically downstream from the pneumatic pump.5. The pneumatic method of claim 1 , wherein pumping air includes pumping negative air pressure claim 1 , and which includes locating a valve for producing the first and second valve states pneumatically upstream from the pneumatic pump.6. The pneumatic method of claim 1 , which includes energizing a first valve so as to produce the first valve state and de-energizing a second valve so as to produce the second valve state.7. The pneumatic method of claim 1 , which includes maintaining a partial load on the pneumatic pump in the second valve state.8. A method of pneumatically operating a dialysis system comprising:(i) selectively enabling air to be pulled in from a fluid flow ...

ENCLOSURE FOR A PORTABLE HEMODIALYSIS SYSTEM

An enclosure for containing a portable hemodialysis unit includes a housing suitable to support components for performing hemodialysis including a dialyzer, one or more pumps to circulate blood through the dialyzer, a source of dialysate, and one or more pumps to circulate the dialysate through the dialyzer. The housing may have a front panel at which blood circuit connections and dialysate fluidic connections are located, e.g., blood line connections for patient blood access, connections for a reagent supply, dialyzer connections for both blood flow and dialysate, etc. The enclosure may also include a pair of vertical, side-by-side doors hingedly mounted to the housing. With the doors in the closed position, access to the patient access and dialysate fluidic connections may be blocked, and the doors may allow for the retention of heat in the housing suitable for disinfection during a disinfection cycle. 1. (canceled)2. An enclosure for a portable hemodialysis apparatus comprising:a housing having a dialysate circuit section separated from a blood circuit section by a front panel,a blood circuit side of the front panel including pneumatic connections for one or more pneumatically actuated blood pumps and fluidic connections for a dialyzer, the front panel configured to allow a dialyzer and one or more blood pumps to be mounted thereon;the dialysate circuit section including a source of dialysate, one or more pneumatically actuated dialysate pumps, and electronic and pneumatic controls for operating the blood and dialysate pumps;wherein the housing includes a connector configured to provide a disengageable pneumatic connection with a power unit to provide positive or negative pneumatic pressure to the pneumatic controls of the hemodialysis apparatus.3. The enclosure of claim 2 , wherein the blood circuit side of the front panel further comprises a reagent connector configured to connect one or more dialysate reagent containers for the production of dialysate solution ...

AMBULATORY LUNG ASSIST DEVICE WITH IMPLANTED BLOOD PUMP AND OXYGENATOR

The present disclosure provides a system for oxygenating blood. The system may include an implantable blood pump that may draw a supply of blood from the circulatory system of a mammalian subject, such as a human being. The blood pump may provide the supply of blood to an adaptor, where the supply of blood may be supplied to either or both of a first branch or second branch. The first branch may lead to an external blood oxygenator. The oxygenator may oxygenate the blood, and the blood may be returned to the circulatory system of the mammalian subject. The second branch may bypass the oxygenator and may connect to the circulatory system of the mammalian subject. In this regard, while the blood is supplied to the second branch, the oxygenator may be disconnected and blood may be prevented from entering the first branch. 1. A system for oxygenating blood comprising:(a) a blood pump having an outlet and an inlet adapted for communication with the circulatory system of a mammalian subject at an inlet location;(b) one or more return fittings adapted for communication with the circulatory system of the subject at one or more return locations remote from the inlet location;(c) a blood oxygenator having a blood inlet releasably connectable in communication with the outlet of the pump and a blood outlet releasably connectable in communication with one of said return fittings; and(d) a bypass conduit adapted to connect the outlet of the pump in communication with one of said return fittings at least when the oxygenator is disconnected.2. A system as claimed in further comprising an oxygenator inlet disconnect fitting connected to the outlet of the blood pump and an oxygenator outlet disconnect fitting connected to one of said return fittings claim 1 , the blood inlet and outlet of the oxygenator being adapted to releasably engage the disconnect fittings.3. A system as claimed in further comprising an adapter having an inlet connected to the outlet of the blood pump claim 2 , ...

Urinary Biomarkers For Predicting Long-Term Dialysis

This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of hyaluronic acid can be used to determine whether a patient having suffered acute kidney injury will require long-term dialysis. 1. A method , comprising:a) obtaining at least two urine samples from a patient exhibiting at least one symptom of an acute kidney injury, wherein said at least two urine samples comprise a first sample and a subsequent sample, wherein said first sample is collected within one day of initiation of a renal replacement therapy;b) detecting hyaluronic acid in said at least two urine samples, wherein said hyaluronic acid in said subsequent sample is elevated as compared to said first sample; andc) predicting said patient to require long-term dialysis within sixty days of said first sample.2. The method of claim 1 , wherein said subsequent sample is collected on the fourteenth day after initiation of said replacement therapy.3. The method of claim 1 , wherein said method further comprises diagnosing said patient with chronic kidney disease.4. The method of claim 1 , wherein said method further comprises entering said patient in a chronic kidney disease prevention program.5. The method of claim 1 , wherein said subsequent sample is collected on the seventh day after initiation of said replacement therapy.6. The method of claim 1 , wherein said first sample is collected on the first day after initiation of said replacement therapy.7. A method claim 1 , comprising:a) obtaining at least two urine samples derived from a patient exhibiting at least one symptom of an acute kidney injury, wherein said patient is at risk for development of chronic kidney ...

Medical device for extracorporal treatment of blood with filter holder

A filter holder for the support of a filter on the casing of a medical device for extra-corporal blood treatment is disclosed. The filter holder has a first grip leg and a second grip leg, which are arranged with respect to each other so that a reception area is formed between the two grip legs. The filter can be inserted into this reception area between the two grip legs, so that the filter is held in the filter holder against the force of gravity. At least one trough- or U-shaped indentation is provided on at least one grip leg, whose cross-section enables the wedging in of a hose. A medical device for extra-corporal blood treatment with such a filter holder for the reception of a filter is also disclosed.

Arteriovenous Access Valve System and Process

An arteriovenous graft system is described. The arteriovenous graft system includes an arteriovenous graft that is well suited for use during hemodialysis. In order to minimize or prevent arterial steal, at least one valve device is positioned at the arterial end of the arteriovenous graft. In one embodiment, a subcutaneous arteriovenous graft system is described. The system includes an arteriovenous graft having an arterial end and an opposite venous end with a first valve device positioned at the arterial end of the arteriovenous graft and a second valve device positioned at the venous end of the arteriovenous graft. The system also includes an actuator having an accumulator. The actuator is in communication with both the first valve device and the second valve device and is configured to cause each valve device to open or close simultaneously. The accumulator assists in maintaining a generally constant pressure when the actuator causes each valve device to close. 1. A subcutaneous arteriovenous graft system comprising:an arteriovenous graft having an arterial end and an opposite venous end;a first valve device positioned at the arterial end of the arteriovenous graft and a second valve device positioned at the venous end of the arteriovenous graft; andan actuator comprising an accumulator, the actuator being in communication with both the first valve device and the second valve device, the actuator being configured to cause each valve device to open or close simultaneously, the accumulator assisting in maintaining a generally constant pressure when the actuator causes each valve device to close.2. A system as defined in claim 1 , wherein each valve device comprises an inner sleeve positioned within an outer sleeve claim 1 , the inner sleeve being attached to the outer sleeve so as to define a discrete area claim 1 , the discrete area being in fluid communication with the actuator wherein claim 1 , when fluid is fed into the discrete area claim 1 , the discrete ...

BLOOD ULTRAFILTRATION SUBSTITUTION TARGET METHOD AND DEVICE

The present invention relates to a method as well as a blood treatment unit for the implementation of this method for the best possible attainment of a predetermined substitution target during the ultrafiltration of blood. According to the invention, a method and a blood treatment unit for the implementation of the method is provided, wherein it is determined by detection of pressure measurement values in the blood treatment unit whether the calculated substitution target is achieved at the end of the dialysis session or not and in case of the result that the calculated substitution target cannot be achieved with the current dialysis parameters, an adjustment of the flow rate of blood, dialysate and/or substituate is performed in order to achieve the substitution target for a given treatment time in an optimal way or modify the treatment time for the given substitution target as little as possible. 112.-. (canceled)13. Blood treatment unit with a dialyzer , at least two pressure sensors , a central processing unit , and a storage unit adapted to perform the following method:a) Determining the filter properties before the treatment by detecting at least two pressure measurement values by at least two pressure sensors within the blood treatment unit using a reference solution,b) Optionally comparing the detected pressure measurement values with reference values of the same patient saved on the storage unit which were detected during previous dialysis sessions or with reference values of a patient group saved on the storage unit,c) Calculating a substitution target based on the values according to step a) and optionally step b),d) Configuring the blood flow rate, dialysate and/or substituate in case of deviation of at least one detected pressure measurement value from the reference pressure measurement value in order to achieve the substitution target for a given treatment time in an optimal way or to modify the treatment time for a given substitution target as little ...

APPARATUS FOR EXTRA-CORPOREAL BLOOD TREATMENT AND METHOD OF DETERMINING A BLOOD FLOW RATE FOR AN EXTRA-CORPOREAL BLOOD TREATMENT APPARATUS

An apparatus and method of determining the blood flow rate at which, in an extra-corporeal blood circuit of an extra-corporeal blood treatment apparatus, blood is pumped through the arterial blood line into the blood chamber of the dialyser and out of its blood chamber through the venous blood line is described. The method and apparatus provide for the determination of a plurality of parameters characteristic of the extra-corporeal blood treatment, with a given blood flow rate being determined in each case as a function of one of the characteristic parameters. A blood flow rate which is preset for the blood treatment is selected from the plurality of blood flow rates determined on the basis of the characteristic parameters. The blood flow rate to be preset is selected on the basis of a preset algorithm which may be implemented in software installed on a data processing unit or in hardware. 1. An apparatus for extra-corporeal blood treatment in which , in an extra-corporeal blood circuit , blood flows through an arterial blood line into a blood chamber of a dialyser which is divided into the blood chamber and a dialysis-fluid chamber by a semi-permeable membrane , and flows out of the blood chamber through a venous blood line , comprising:a blood pump for pumping blood in the extra-corporeal blood circuit at a preset blood flow rate,an arrangement for presetting the blood flow rate at which the blood pump for pumping blood in the extra-corporeal blood circuit is operated, thus causing blood to flow through the extra-corporeal blood circuit at the preset blood flow rate,at least one arrangement for determining at least one parameter characteristic of the extra-corporeal blood treatment, andat least one arrangement for determining at least one blood flow rate as a function of one parameter characteristic of the extra-corporeal blood treatment from the at least one parameter characteristic of the extra-corporeal blood treatment,wherein the arrangement for presetting the ...

Home Medical Device Systems and Methods for Therapy Prescription and Tracking, Servicing and Inventory

A home medical device system includes a plurality of home therapy machines that perform a home therapy on a patient; a connectivity server; a system hub coupled to the home therapy machines through the connectivity server; a web portal configured to access the system hub; a plurality of clinics connected to the system hub via the web portal; and a website accessible via the web portal, the website including a patient portion available to patients using the plurality of home therapy machines, the website further including a clinician portion that enables the clinics to manage the home therapy machines.

Filtration system for preparation of fluids for medical applications

Systems, methods, and devices for preparation of water for various uses including blood treatment are described. In embodiments, fluid is passed through a first filtration step which is effective for creating purified water and a pair of ultrafilters placed at the outlet. The ultrafilters are separated by an intervening flow path to prevent grow-through from the outlet end upstream. In embodiments, a recirculation path with an air removing filter helps to eliminate air from the ultimate product water.

CONNECTOR AND MEDICAL DEVICE FOR EXTRACORPOREAL BLOOD TREATMENT COMPRISING SUCH CONNECTOR

A connector adapted to be detachably arranged in an opening of a housing of a medical device and including a connecting element to which a single-use article can be connected outside of the housing is disclosed. Via a hollow link portion the connecting element is connected to a coupling adapted to be inserted into the interior of the housing through the opening of the housing. Moreover, the connector includes a spring element adapted to be detachably arranged at the link portion so that the connector is supported at the housing to be axially resilient via the spring element. A medical device for extracorporeal blood treatment including such connector as an interface to a single-use article, for example, is also disclosed. 1. A connector which is adapted to be detachably arranged in an opening of a housing of a medical device and includes a connecting element , especially in the form of a male Luer cone to which a single-use article can be connected outside the housing , wherein the connecting element is connected via a hollow link portion to a coupling adapted to be introduced through the opening of the housing into the interior of the housing; and the connector further comprises a spring element adapted to be detachably arranged at the link portion so that the connector is supported at the housing to be axially resilient via the spring element.2. The connector according to claim 1 , wherein the connector claim 1 , especially at the link portion claim 1 , means for rotary fixing of the connector inside the opening of the housing are provided.3. The connector according to claim 1 , wherein the spring element is adapted to be axially or radially slipped onto the link portion claim 1 , wherein at the link portion at least one groove is provided for axially and positively fixing the spring element.4. The connector according to claims 1 , wherein the spring element is in the form of a disk spring or leaf spring claims 1 , includes a central opening and a segment-shaped ...

CONCENTRATE CONTAINER HAVING SUPPORTING ELEMENTS

The invention relates to a container for dialysis concentrates, in particular acidic dry concentrates. When these dry concentrates are dissolved directly by the dialysis machine to form liquid concentrates, the containers must provide a volume of 4-12 liters. To impart the required stability to these containers, they have integral supporting elements, which manifest their supporting function only when the container is used on the dialysis machine. 1. A container containing a concentrate suitable for preparing at least one dialysis solution , having at least one connecting means by which the container can be connected to a dialysis machine or to a preparation unit for liquid concentrates , wherein the container has integrated supporting elements that exert their supporting function only when fluid is supplied and/or a gas is supplied through the dialysis machine or the preparation unit into the container.2. The container according to claim 1 , characterized in that the concentrate is a dry concentrate.3. The container according to claim 1 , characterized in that the supporting element is an air cushion.4. The container according to claim 1 , characterized in that the air cushion is designed in the form of an outer bag around the concentrate-filled inner bag.5. The container according to claim 1 , characterized in that the inner bag and the outer bag are connected by a non-return valve.6. The container according to claim 1 , characterized in that it has an insertion means for air and has a vent means.7. The container according to claim 1 , characterized in that the supporting element is a folded foot which unfolds as the container is filled and then exerts the supporting function.8. The container according to claim 1 , characterized in that it is self-standing according to the characteristic of the supporting function.9. Use of a container according to claim 1 , wherein the container is used to prepare a concentrate claim 1 , in particular an acidic liquid concentrate ...

DEVICE AND METHOD FOR CREATION AND DISPLAY OF GRAPHIC CODING SPECIFIC FOR MEDICAL DEVICES AND MEDICAL TREATMENTS

The present invention relates to the field of information display and forwarding with medical machines, in particular display and forwarding of information pertaining to the medical machine such as treatment information, equipment information and software codes. The invention is based on the problem of providing the patient with information about his/her treatment in a simple and convenient manner and/or providing the operator or service personnel of the medical machine information pertaining to the equipment of the medical machine and/or its software options in a simple and convenient manner. A method and a device in which characteristic graphic codes are generated and displayed and which can be input and decoded by a portable device are proposed for this purpose. 1. A method for display of information pertaining to a medical device , comprising the steps:generating a graphic code which is characteristic of the information pertaining to the medical device,displaying the graphic code.2. The method according to claim 1 , wherein the graphic code is a barcode or a QR code.3. The method according to claim 1 , wherein the information is treatment-related data.4. The method according to claim 1 , wherein the information pertains to the unlocking key of software or software options.5. The method according to claim 1 , wherein the information pertains to the equipment or the status of the medical device.6. The method according to claim 1 , wherein the information displayed is entered by a user with a portable device for further processing.7. The method according to claim 6 , wherein the further processing comprises:sending the information to a remote device by the portable device,generating an unlocking key from the received information in the remote device.8. The method according to claim 7 , wherein the unlocking key is transmitted to the portable device and/or to the medical device.9. A medical device having a display device and a control unit claim 7 , wherein the ...

Cloned biological material medical device and method thereof

A medical device, said medical device, comprises: a first component having a non-biological material; a second component having a cloned biological material, said second component being attached to said first component, wherein said first component and said second component are operatively associated in a non-living medical device for at least one of treatment, diagnosis, cure, mitigation and prevention of disease, injury, handicap or condition in a living organism. In another aspect, a method comprises: preparing a cloned biological material from a tissue or an organ; attaching said biological material to a medical device; interfacing said biological material with the non-biological material; providing treatment, diagnosis, cure, mitigation and prevention of disease, injury, handicap or condition in a living organism.

Magnetic sensors and related systems and methods

This invention relates generally to magnetic sensors and related systems and methods. In some aspects of the invention, a magnetic sensor assembly includes a housing configured to releasably hold a medical fluid tube and a sensor secured to the housing, the sensor configured to detect a change in a strength of a magnetic field when a medical fluid passes through the medical fluid tube.

Devices, systems, and methods for cleaning, disinfecting, rinsing, and priming blood separation devices and associated fluid lines

Systems and methods for providing for the automatic instrument-based rapid reprocessing of an intact extracorporeal circuit for use in hemodialysis. The system includes a manifold with connectors for engaging a dialyzer as well as venous and arterial blood lines. The manifold is adapted to be moved from a dialysis machine to a reuse instrument without removing the dialyzer and associated blood lines. The system allows for reprocessing of the extracorporeal circuit wherein prior to the next treatment, there is no residual chemical disinfectant requiring testing, the extracorporeal circuit is pre-primed, the levels in the bubble traps are set, and all of the required quality assurance tests are performed and recorded.

Zirconium Phosphate Particles Having Improved Adsorption Capacity And Method Of Synthesizing The Same

Zirconium phosphate particles are synthesized by providing a solution of zirconium oxychloride in an aqueous solvent, adding at least one low molecular weight, oxygen containing, monofunctional, organic additive to the solution, and combining this solution with heated phosphoric acid or a phosphoric acid salt to obtain zirconium phosphate particles by sol gel precipitation. 128-. (canceled)29. Zirconium phosphate (ZrP) particles having the following characteristics:an average particle size of about 45-90 microns,{'sup': '2', 'a BET surface area of at least 2 m/g ZrP, and'}{'sub': 4', '4, 'an ammonia capacity in dialysate of at least about 15 mg NH—N/g ZrP, at 20 mg/dL NH—N.'}30. The particles of having a BET surface area of at least 10 m/g ZrP.31. The particles of further having a pore volume of at least 0.0071 mL/g claim 29 , a monolayer volume of at least 0.5 mL/g (STP) claim 29 , and a 20-80 nm pore size content of at least 30%.32. A dialysis cartridge comprising a cartridge that contains the zirconium phosphate particles of .33. Zirconium phosphate (ZrP) particles having the following characteristics:a pore volume of at least 0.0071 mL/g,a monolayer volume of at least 0.5 mL/g (STP), anda 20-80 nm pore size content of at least 30%.34. A dialysis cartridge comprising a cartridge that contains the zirconium phosphate particles of . This application claims the benefit under 35 U.S.C. §119(e) of prior U.S. Provisional Patent Application No. 61/102,466, filed Oct. 3, 2008, which is incorporated in its entirety by reference herein.The present invention relates to zirconium phosphate particles, and to methods of making zirconium phosphate particles, such as by sol gel synthesis, that have improved porosity, BET surface area, and/or ammonium ion adsorption properties.Zirconium phosphate (ZrP) particles are used as ion exchange materials and are particularly useful as a sorbent material for regenerative dialysis. Zirconium phosphate (ZrP) particles can be synthesized by ...

Reduction of galectin-3 levels by plasmapheresis

The invention is directed to the removal of serum gal-3 from circulation by plasmapheresis using gal-3 binding agents in either a fixed bed, or in a form easily removed, such as by being complexed with magnetic particles. This method, on its own, brings a sharp reduction and relief from the inflammation and fibroses that can be induced by circulating gal-3. The process may be combined with the administration of gal-3 binding agents, such as modified citrus pectin, to further lower unbound gal-3 levels, to the point where gal-3 in the tissues may be addressed. This method may also be combined with removal of TNF receptors to provide an effective treatment for cancer.

METHOD FOR CALCULATING OR APPROXIMATING A VALUE REPRESENTING THE RELATIVE BLOOD VOLUME AND DEVICES

The present invention relates to a method for calculating or approximating a value representing the relative blood volume (RBV) at a certain point of time, or a value representing the refilling volume of a patient that may be observed or found during or due to a blood treatment of the patient, the method involving considering one or more calculated or measured value(s) reflecting an overhydration level of the patient or an approximation thereof. It relates further to an apparatus and a device for carrying out the present invention, a blood treatment device, digital storage means, a computer program product, and a computer program. 1. A method for calculating or approximating or predicting a value representing the absolute blood volume (BV) or the relative blood volume (RBV) at a certain point of time or the normalized or normohydrated relative blood volume (RBV_normohyd(t)) , or a value representing a refilling volume (V_refill) of a patient that may be observed or found or calculated or measured during or due to a blood treatment of the patient , the method comprising the step of considering one or more calculated or measured value(s) reflecting an overhydration (OH) level or an overhydration of the patient or an approximation thereof.2. The method according to claim 1 , wherein for calculating or approximating or predicting a value representing the relative blood volume (RBV) or a value representing the refilling volume (V_refill) claim 1 , the absolute start blood volume (BV_start) upon or before beginning of the blood treatment is considered.3. The method according to claim 2 , wherein for assessing the absolute start blood volume (BV_start) at least one value reflecting the lean mass (LTM) and at least one value reflecting the fat mass (ATM) of the patient's body claim 2 , or approximations thereof claim 2 , are considered.4. The method according to claim 1 , further comprising the step of predicting an end value of the relative blood volume (RBV) arrived at by ...

Capacitance-Based Patient Line Blockage Detection

A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a pressure sensor mounted at a proximal end of a patient line made of a distensible material that provides PD solution to a patient through a catheter. During treatment, an occlusion can occur at different locations in the patient line and/or the catheter. When an incremental volume of additional solution is provided to the patient line while the occlusion is present, a change in pressure results. The change in pressure depends on the dimensions and the distensibility of the non-occluded portion of the patient line. If the change in pressure, the incremental volume, the properties related to the distensibility of the patient line, and some of the dimensions of the patient line are known, the location of the occlusion can be inferred. The occlusion type can be inferred based on the determined location. 1. A method comprising:measuring a first pressure of fluid in a first portion of a distensible medical tube connected to a medical device, wherein an occlusion is present in the medical tube at a location that defines a boundary between the first portion and a second portion of the medical tube;providing or withdrawing a volume of fluid to or from the first portion of the medical tube;measuring a second pressure of the fluid in the first portion of the medical tube; anddetermining a length of the first portion of the medical tube based on a difference between the second pressure and the first pressure.2. The method of claim 1 , wherein the medical device comprises a dialysis machine.3. The method of claim 2 , wherein the dialysis machine comprises a peritoneal dialysis (PD) machine.4. The method of claim 1 , wherein the length of the first portion represents the location of the occlusion relative to a proximal end of the medical tube connected to the medical device.5. The method of claim 1 , wherein the first pressure and the second pressure are measured by a pressure sensor at a proximal end of ...

A VENOVENOUS ECMO (EXTRACORPOREAL MEMBRANE OXYGENATION) CANNULA

This invention is related to a dual lumen triple brimmed venovenous ECMO (Extracorporeal Membrane Oxygenation) cannula (). 1. A cannula for oxygenation of contaminated blood and returning the blood to patient characterized in that said cannula comprises:at least one body having a plurality of openings in which the blood is collected and sprayed, the body being in a double lumen structure with ends from which dirty blood leaves the body and the clean blood enters the body;at least one anti-bacterial coating located on the upper part of the body that is in contact with the patient's skin;more than one indicator that determines the level and that is located on the upper part of the body, in the opening wherein the blood is ejected and at the lower part of the body;at least one reinforced area that is resilient and resistant to breakage and located in the upper part of the body;at least one upper venous opening located on the body into which the venous blood enters;at least one arterial opening having an indicator wherein clean blood is ejected, at least one lower venous basket end located at the lower end of the body and having at least one basket end opening;at least one lower end hole on the body, which is located such that it is on the upper side of the lower venous basket end;at least one clamp securing the body on the patient's skin;a body that is elliptical in shape in order to increase the amount of blood sucked and is formed by non-concentric lumen placement wherein the lumen in the elliptical body that is used to inject blood has a circular cross section.2. A cannula according to claim 1 , characterized in that said cannula comprises a body comprising two ends connected with lumens and wherein said ends perform their functions separately at the upper part of the body and from which the venous blood exits and is returned back to the system after cleaning.3. A cannula according to characterized in that said cannula comprises a body comprising preferably two ...

Method and device to monitor patients with kidney disease

A medical monitoring device for monitoring electrical signals from the body of a subject is described. The medical monitoring device monitors electrical signals originating from a cardiac cycle of the subject and associates each cardiac cycle with a time index. The medical monitoring device applies a forward computational procedure to generate a risk score indicative of hyperkalemia, hypokalemia or arrhythmia of the subject. The medical monitoring device can adjust the forward computational procedure based upon clinical data obtained from the subject.

Fluid Line Connector Devices Methods and Systems

A frangible connector has a first side that forms a female luer when a second side is fractured at a predefined break line. The second side may be connected to a fluid circuit, for example, a source of medical treatment fluid such as dialysate. 1. A connector device , comprising:an inline fluid channel element having first and second end portions adapted for bonding to tubing segments;the inline fluid channel element having a middle portion defining a connector attached to the second end portion through a frangible portion that, when fractured, renders the connector operable to connect with a predefined mating connector.2. The device of claim 1 , wherein the connector device is shaped such that the connector that results from fracturing the frangible portion is of a female locking luer type.3. The device of claim 2 , wherein the connector device is shaped such that the connector that results from fracturing the frangible portion has thread portions.4. The device of claim 1 , wherein the connector device is shaped such that the connector that results from fracturing the frangible portion has an opening shaped to receive the mating connector claim 1 , a mouth of the opening coinciding with a circular channel defining the frangible portion.5. The device of claim 1 , wherein the inline fluid channel is generally cylindrical in shape.6. The device of claim 1 , further comprising a fluid circuit for a renal replacement therapy device permanently bonded to the first end portion.7. The device of claim 1 , further comprising a releasably capped connector connected to the second end portion.8. The device of claim 7 , wherein the releasably capped connector is of a locking luer type.9. The device of claim 1 , wherein the second end portion is connected to a tubing segment and with a pre-installed non-reopenable clamp.10. The device of claim 9 , further comprising a fluid circuit for a renal replacement therapy device permanently bonded to the first end portion.11. The device ...

APPARATUS, PROCESS AND SYSTEM FOR MONITORING A PLURALITY OF PATIENTS AFFECTED BY KIDNEY FAILURE

An apparatus, a process and a system for monitoring a plurality of patients (P) affected by kidney failure over a time frame (T) are disclosed. The system includes blood treatment units, laboratory storage units, at least one hub module, and client units. The system collects values (VM) of a plurality of session parameters, set values (VS) of a plurality of prescription parameters, values (VL) of a plurality of laboratory parameters and the hub module stores values (KPVi) of selected parameters (KPi) which are a subclass of the collected values (VM, VS, VL) and which are transferred to the client units. Each client unit may define, for each of said patients, a number of indicators (IDk) based on the values (KPVi,k) taken by a respective subclass (KPi,k) of said selected parameters (KPi) and to operate the respective display according to various display modes. 134-. (canceled)36. An apparatus according to claim 35 , wherein the control unit is further configured to:{'sub': i,k', 'i,k', 'k, 'compare the values (KPV) taken, over the time frame (T), by the subclasses of selected parameters (KP) affecting a same indicator (ID) with respective reference criteria;'}signal whether one or more of said criteria are not met.37. An apparatus according to claim 35 , wherein the control unit is configured to remotely connect with a hub module and receive claim 35 , at time intervals claim 35 , the values (KPV) of selected parameters (KP) contained in a hub module memory.38. An apparatus according to claim 35 , wherein the control unit is configured to interrogate a hub module at a plurality of regular time intervals during said time frame in order to collect a plurality of sets of values (KPV) of selected parameters (KP) claim 35 , each set referring to a respective time interval.39. An apparatus according to configured for connection to said system claim 35 , which is further configured for:{'sub': i', 'i, 'storing, in a memory of a hub module part of the system, values (KPV) of ...

Packaging and Organizing Coils of Medical Tubing

A device and method for holding coils of medical tubing is provided to simplify packaging and organizing the various coils of medical tubing needed for a medical device. This will make it easier for the patient to manipulate each coil of tubing, particularly in a home setting involving a home dialysis machine operated by the patient. The tube holding device advantageously reduces the probability of entanglement and groups the coils of tubing individually. It also mitigates and/or eliminates the need for tape to bundle the coils. Specifically, benefits of the tube holding device according to the system described herein include: reduced cost; ease-of-use; prevention of entanglement of coils of tubing; ease of packaging and shipping; and does not require packaging tape to bundle tubing.

ADAPTIVE SYSTEM FOR BLOOD FLUID REMOVAL

Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session. 1. A method carried out by a blood fluid removal system , comprising:storing a second data in a most effective to date data set; wherein the second data is data regarding system parameters employed in a first blood fluid removal session of a patient; and wherein a first data is data regarding the patient, the first data including one or more of a physiological parameter and time since last blood fluid removal session prior to the first blood fluid removal session of the patient; wherein at least one physiological parameter is measured in a dialysate;storing the second data in a least effective to date data set;determining whether at least one physiological parameter in a third data is closer to a target value than the first data; and replacing the data in the most effective to date data set with a fourth data if the third data is closer to the target value than the first data;wherein the third data is data regarding the patient, the data including one or more of a physiological parameter and time since last blood fluid removal session prior to a second blood fluid removal session of the patient; wherein at least one physiological parameter is measured in a dialysate; and wherein the fourth data is data regarding system parameters employed in the second blood fluid removal session of the patient;determining whether at least one physiological parameter in the third data is further from a target value than the first data; and replacing the data ...

Device, system and method for killing viruses in blood through electrode wires

A device for killing blood-borne pathogens, and a method of using this device to effectively remove blood-borne pathogens from the body of a human or animal is claimed. The device comprises a wire that is inserted into the blood stream of a patient, which releases metallic ions which effectively kill the pathogens. There are several embodiments, each of which has a combination of covered and uncovered portions of the wire. The wire is electrically connected to both a source of power and a Power Supply with PCB or controller/software, which controls the intensity and during of the treatment. 2. The device of claim 1 , where the electrode is a two-part electrode with a first electrode part and a second electrode part claim 1 , where the first electrode part is a proximal end unit claim 1 , where the proximal end contains a conductive pin claim 1 , where the conductive pin comprises copper claim 1 , where the conductive pin is held within a lure claim 1 , where the conductive pin allows the transfer of a low intensity direct current to the iontophoretic wire from the power supply claim 1 , where the pin can be tightened onto the second part through a tightening device claim 1 , and where the second part is a second part electrode claim 1 , where the second part electrode has a length of exposed wire at the distal end.3. The device of claim 2 , where the length of exposed wire at the distal end is a bare silver wire.4. The device of claim 2 , where the length of exposed wire at the distal end is a skived window.5. The device of claim 2 , where the tightening device is a set screw.6. The device of claim 2 , where the tightening device is a quantity of conductive glue.7. The device of claim 1 , where the second metal is combination of gold and silver.8. A device for treating a blood borne pathogen within a blood stream comprisingan iontophoretic wire, where the iontophoretic wire comprises one or more metals;a transformer, where the transformer comprises a plurality of ...

VALVE FOR A DIALYSIS MACHINE AND DIALYSIS MACHINE

A pressure compensation valve for a dialysis machine is disclosed. The pressure compensation valve has a valve housing, in which a flow path with fresh dialysate is separated from a flow path with exhausted dialysate by a diaphragm. The diaphragm and the valve housing are configured such that pressure compensation is possible. In addition, the diaphragm is configured such that no vibrations or a reduced amount of vibrations and/or no noise emission or a reduced amount of noise emission will occur during operation. Furthermore, a dialysis machine comprising such a pressure compensation valve is disclosed. The dialysis machine comprises a balancing unit, and the pressure compensation valve is arranged on the outlet side of the balancing unit. 115-. (canceled)16. A valve for a dialysis machine , comprising:a valve housing having formed therein a first flow path in fluid communication with a first inlet connection and a first outlet connection and a second flow path in fluid communication with a second inlet connection and a second outlet connection,an equalizer element arranged within the valve housing that equalizes pressures of the flow paths and through which the fluids of respective flow paths operatively interact, the equalizer element having associated therewith a valve seat.17. The valve according to claim 16 , wherein the equalizer element is a diaphragm claim 16 , which is acted upon by the fluid of the first flow path and by the fluid of the second flow path and which is provided with a diaphragm projection.18. The valve according to claim 17 , wherein the diaphragm is configured as a sealing element for fluidically separating the first and second flow paths.19. The valve according to claim 17 , wherein the second flow path comprises a fluid space into which a channel section of the second flow path opens claim 17 , the diaphragm projection being adapted to be introduced into said channel section.20. The valve according to claim 19 , wherein an outlet opening ...

Associating Dialysis Accessories Using Near Field Communication

A method comprising: establishing a wireless connection between a first medical device and a second medical device, comprising: receiving, by the first medical device, via a short-range wireless technology protocol, connection information related to the second medical device; and establishing, by the first medical device, a wireless connection with the second medical device based on the connection information. 1. A method comprising: receiving, by the dialysis machine, via a short-range wireless technology protocol, a wireless identifier associated with the peripheral device, wherein the dialysis machine receives the wireless identifier from the peripheral device as a result of detecting that the dialysis machine and the peripheral device are positioned within a communication range of the short-range wireless technology protocol; and', 'establishing, by the dialysis machine, a wireless connection with the peripheral device based on the wireless identifier using a communication protocol other than the short-range wireless technology protocol, wherein the peripheral device is granted permission to control functions of the dialysis machine and deliver data to the dialysis machine using the wireless connection., 'establishing a wireless connection between a dialysis machine and a peripheral device, comprising2. The method of claim 1 , wherein the dialysis machine receives the wireless identifier from the peripheral device as a result of detecting that the dialysis machine and the peripheral device are within a threshold distance of each other.3. The method of claim 1 , comprising:receiving, by a connection device, from the peripheral device, via the short-range wireless technology protocol, the wireless identifier; andproviding, by the connection device, to the dialysis machine, via the short-range wireless technology protocol, the wireless identifier.4. The method of claim 3 , wherein the connection device is a wand.5. The method of claim 3 , wherein the connection ...

DISPLAY DEVICE FOR MEDICAL APPARATUS

A display device for a medical apparatus including a projection surface arranged on the medical apparatus and configured to present a predetermined display content in a way visible to a user of the medical apparatus, and a projection device arranged on the medical apparatus and configured to project the predetermined display content from a rear side of the projection surface onto the projection surface. The projection surface and the projection device are configured as a head-up display unit for visual field presentation of the display content, and the medical apparatus may be an apparatus for carrying out extracorporeal blood treatment including the display device. 111.-. (canceled)12. A display device of a medical apparatus , comprising:a projection surface mounted to the medical apparatus and configured to present a predetermined display content to a user of the medical apparatus on a front side of the projection surface; anda projection device mounted on the medical apparatus and configured to project the predetermined display content from a rear side of the projection surface onto the projection surface;wherein a predetermined portion of the projection surface is provided for displaying at least one predetermined operating condition of the medical apparatus, and in at least a first and a second operating condition at least one of a predetermined first portion or a predetermined second portion of the projection surface is controllably configured to display the first and second operating conditions in different colors.13. The display device according to claim 12 , wherein the projection surface is a translucent projection surface made from semi-opaque material.14. The display device according to claim 12 , wherein at least the projection surface is arranged to be at least one of tiltable claim 12 , rotatable or height-adjustable.15. The display device according to claim 12 , further comprising at least one interactive element which is arranged on the projection ...

EXTRACORPOREAL BLOOD TREATMENT MACHINE COMPRISING LEAKAGE DETECTION AND METHOD OF DETECTING LEAKAGES IN DIALYSIS FLUID SYSTEMS

The invention relates to an extracorporeal blood treatment machine, such as a dialysis machine, comprising leakage detection as well as to a method of detecting leakages in the dialysis fluid circuit of a dialysis machine, wherein at least part of the dialysis fluid system to be monitored in terms of leakage is accommodated in a hermetically sealed housing and the housing is or can be ventilated in a controlled manner, and wherein a parameter, such as the air humidity of the air flowing into the housing is compared to a corresponding parameter, preferably air humidity of the air flowing out of the housing. 1. A method of detecting leakage in a dialysis fluid system of an extracorporeal blood treatment machine in which a housing including a first ventilation aperture and a second ventilation aperture and otherwise being hermetically sealed contains at least part of the dialysis fluid system to be detected in terms of leakage , the method comprising:ventilating the housing via the ventilation apertures,detecting at least one parameter of inlet air supplied to the housing and of outlet air discharged from the housing;comparing the inlet air and the outlet air detected parameters to identify a difference; anddetermining a humidity input to the housing which does not originate from the ambient air from the identified difference.2. The method according to claim 1 , wherein the treatment machine is a dialysis machine.3. The method according to claim 1 , wherein the at least one parameter includes at least one of air mass claim 1 , temperature or humidity.4. The method according to claim 1 , wherein the at least one parameter of the inlet air flowing into the housing or the outlet air flowing out of the housing are detected in discrete measuring cycles.5. The method according to claim 1 , further comprising claim 1 , when the at least one parameter is indicative of leakage claim 1 , performing a plausibility check by reversing flow of the air through the housing and ...

FLUID LEAK DETECTION IN A DIALYSIS MACHINE

A dialysis machine (e.g., a peritoneal dialysis machine) may include a housing. The machine may further include a leak detector disposed in the housing, the leak detector being an electrical circuit. In response to fluid contacting the leak detector, a leak in the dialysis machine is detectable. The machine is configured to send a signal based on a short of the electrical circuit from fluid contact with the leak detector to indicate a leak condition. 1. A dialysis machine , comprising:a housing including a cavity; anda leak detector disposed in the cavity of the housing, the leak detector being an electrical circuit;wherein in response to fluid contacting the leak detector, a leak in the dialysis machine is detectable.2. The dialysis machine according to claim 1 , wherein the dialysis machine is configured to send a signal based on a short of the electrical circuit from fluid contact with the leak detector to indicate a leak condition.3. The dialysis machine according to claim 1 , wherein the leak detector is disposed in a lower portion of the housing abutting an internal edge of the lower portion of the housing.4. The dialysis machine according to claim 1 , wherein the leak detector is coupled to a leak detector casing claim 1 , the leak detector casing at least partially covering the leak detector.5. The dialysis machine according to claim 4 , wherein the leak detector casing includes a plurality of openings.6. The dialysis machine according to claim 1 , wherein the leak detector includes a first portion claim 1 , a second portion disposed at a first end of the first portion claim 1 , and a third portion disposed at a second end of the first portion opposite of the first end.7. The dialysis machine according to claim 6 , wherein the first portion is substantially perpendicular to the second portion and the third portion and the second portion is substantially parallel to the third portion.8. The dialysis machine according to claim 4 , wherein the leak detector is ...

SYSTEM FOR REMOVING UREMIC TOXINS IN DIALYSIS PROCESSES

A dialysis system comprising: a sorbent cartridge including a zirconium phosphate layer followed by at least one of a urease layer, a zirconium oxide layer, or a carbon layer; a pump in fluid communication sorbent cartridge; and a control unit in operable communication with the pump, wherein the control unit is programmed to cause the pump to pump a dialysis fluid to flow (i) in a first direction through the sorbent cartridge, wherein the zirconium phosphate layer is contacted by the dialysis fluid before the at least one of the urease layer, zirconium oxide layer or carbon layer and (ii) in a second direction through the sorbent cartridge wherein the at least one of the urease layer, zirconium oxide layer or carbon layer is contacted by the dialysis fluid before the zirconium phosphate layer. 1. A dialysis system comprising:a sorbent cartridge in fluid communication with at least one of a patient or a dialyzer, the sorbent cartridge including a housing having a urease layer followed by a zirconium phosphate layer;a storage container in fluid communication with the sorbent cartridge;a pump in fluid communication with the sorbent cartridge and the storage container; anda control unit in operable communication with the pump, wherein the control unit is programmed to cause the pump to pump a dialysis fluid to flow (i) in a first direction through the sorbent cartridge, wherein the urease layer is contacted by the dialysis fluid before the zirconium phosphate layer and (ii) in a second direction, reverse from the first direction, through the sorbent cartridge wherein the zirconium phosphate layer is contacted by the dialysis fluid before the urease layer.2. The dialysis system of claim 1 , wherein the control unit is programmed to cause the pump to recirculate the dialysis fluid through the sorbent cartridge for at least two cycles claim 1 , after which the dialysis fluid is stored in the storage container.3. The dialysis system of claim 2 , wherein the control unit is ...

System and Method For Monitoring Cardiac Blood Flow Balance Between The Right and Left Heart Chambers

A system for measuring of cardiac blood flow balance parameter between the right chamber of the heart and the left chamber of the heart includes a sensor device for measuring one of blood pressure and blood flow rate and blood constituent concentration of a patient so as to generate an arterial pulse signal. A processing unit is responsive to the arterial pulse signal for generating a full arterial pulse signal, an arterio-venous pulse signal, and a balance parameter. A computational device is responsive to the balance parameter for further generating a set of physiological parameters. A display station device is responsive to the set of physiological parameters from the computational device for displaying meaningful information. 1. A system for measuring of cardiac blood flow balance parameter between the right chamber of the heart and the left chamber of the heart , comprising:sensing means for measuring one of blood pressure and blood flow rate and blood constituent concentration of a patient so as to generate an arterial pulse signal;processing means responsive to said arterial pulse signal for generating a full arterial pulse signal, defined as the measured arterial pulse signal without the effect of atrial diastolic blood flow demand;said processing means for subtracting said arterial pulse signal from said full arterial pulse signal so as to generate an arterio-venous pulse signal;said processing means further calculating a transfer function relationship of said arterio-venous pulse signal to said full arterial pulse signal to generate a balance parameter representation;computational means being responsive to said balance parameter representation for further generating a set of physiological parameters; andoptional display monitoring means responsive to said set of physiological parameters from said processing means for displaying meaningful information.2. A system for measuring of cardiac blood flow balance parameter as claimed in claim 1 , wherein said ...

MEDICAL FLUID THERAPY MACHINE INCLUDING READILY ACCESSIBLE PNEUMATIC MANIFOLD AND VALVES THEREFORE

A connection apparatus for sealing to a pathway of a mounting structure includes a body; and a port including a threaded portion extending from the body and a non-threaded portion extending from the threaded portion, the non-threaded portion carrying a gasket, the gasket positioned along the non-threaded portion such that the mounting structure to which the connection apparatus is mounted contacts the gasket prior to the threaded portion engaging a mating threaded portion of the mounting structure, the port providing fluid communication between the body and the pathway of the mounting structure. The body may be that of a valve that supplies any of air, water or oil as an operating fluid to, for example, inlet and outlet valves and a pump chamber of a medical fluid pump of a medical fluid delivery machine. 1. A medical fluid delivery machine comprising:a medical fluid pump including a pneumatically actuated pump chamber and first and second pneumatically actuated medical fluid valve chambers located respectively upstream and downstream of the pneumatically actuated pump chamber;at least one of a positive air pressure source or a negative air pressure source for supplying positive or negative pressure air, respectively, to at least one of the pneumatically actuated pump chamber, the first pneumatically actuated medical fluid valve chamber, or the second pneumatically actuated medical fluid valve chamber;a pneumatic manifold including an air passageway in fluid communication with (i) at least one of the pneumatically actuated pump chamber, the first pneumatically actuated medical fluid valve chamber, or the second pneumatically actuated medical fluid valve chamber and (ii) the at least one positive or the negative air pressure source, the pneumatic manifold defining a manifold aperture; anda pneumatic valve defining a valve aperture sized and arranged such that when the pneumatic valve is abutted against the pneumatic manifold, the valve aperture mates with the ...

Medical Device With Additively Applied Converter Including A Conductive Path

This disclosure relates to a medical device including, a hard part, a converter, and a conductive path. The hard part has fluid paths for guiding a medical fluid, in particular blood, through the hard part. The converter is arranged to measure a characteristic of the medical fluid while the fluid is present in one of the fluid paths. At least a first section of the converter or of the conductive path is applied to or superimposed on the hard part by a first additive application method. At least a second section of the converter or of the conductive path is applied to the hard part by a second application method. The first and the second additive application methods differ from each other. 116-. (canceled)17. A medical device comprising:a hard part with fluid paths for guiding a medical fluid through the hard part;a converter, wherein the converter is arranged to measure a characteristic of the medical fluid while the medical fluid is present in one of the fluid paths; anda conductive path,wherein at least a first section of the converter or of the conductive path is applied to or superimposed on the hard part by a first additive application method,wherein at least a second section of the converter or of the conductive path is applied to the hard part by a second application method, andwherein the first and the second additive application methods differ from each other.18. The device according to claim 17 , wherein the first application method claim 17 , or the second application method claim 17 , or both the first and second application methods encompass applying conductive ink.19. The device according to claim 17 , wherein the first application method claim 17 , or the second application method claim 17 , or both the first and the second application methods include template-free application.20. The device according to claim 17 , wherein the medical device comprises a plurality of converters each comprising at least one section claim 17 , wherein each of the at ...

Patient scales with camera-supported monitoring and a dialysis therapy system with camera-controlled weighing process

A weight detection device is disclosed for determining a patient's weight, for dialysis treatment, that includes patient scales arranged to carry out a weighing procedure to detect the actual weight of a patient, preferably a network connection arranged to connect a component of the weight detection device, generating information and/or data related to the determining of the patient's weight and/or to the weighing procedure, to a data network, an output device arranged to output the actual weight of the patient, and an image information recording device that includes a field of view directed to the patient scales for the visual detection of weighing procedures arranged to record the course of a weighing procedure such that a cause of a change in the actual weight occurring in the course of dialysis therapy can be determined from a recording of the weighing procedure.

DEVICE AND METHOD FOR SUPPLYING TREATMENT PARAMETERS FOR TREATMENT OF A PATIENT

A method is disclosed for supplying treatment parameters for a dialysis treatment, comprising the following steps: 1. A method for supplying treatment parameters for a dialysis treatment , comprising the following steps:{'b': 208', '301', '209', '302', '214', '303', '204', '304, 'supplying a predetermined machine-related data record of machine-related treatment parameters that are stipulated independently of the treatment of a certain person (, ), supplying a patient-related data record from patient-related treatment parameters of a patient (, ) to be treated, Independently of a dialysis machine or a type of device provided for the treatment, selection of a machine-related data record for a certain dialysis treatment of a patient (, ), and using the machine-related data record and the patient-related data record for generating a treatment data record for defining treatment parameters for the dialysis treatment (, ) to be performed.'}2. The method according to claim 1 , comprising:supplying a plurality of machine-related data records as a function of the respective type of machine for a plurality of types, of dialysis machines, determining the type of dialysis machine provided for a certain treatment, selecting the machine-related data record as a function of the type of machine thereby determined.3. The method according to claim 2 , wherein the step of supplying a plurality of machine-related data records as a function of the respective type of machine is performed in a monitoring system for monitoring a plurality of dialysis machines.4. The method according to claim 1 ,wherein the machine-related treatment parameters are selected from a group of:{'b': '5', 'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'a basic form of a treatment profile including a basic form of an ultrafiltration profile or a concentration profile for the dialysis fluid, the patient data record comprising a treatment parameter including an ultrafiltration amount or a total concentration, and ...

EXTRACORPOREAL BLOOD TREATMENT MACHINE

A machine for extracorporeal blood treatment includes a user interface having a touch screen and a controller programmed to display on a screen () a display in which two distinct areas are arranged, one of which () exhibits a series of touch keys (), wherein activation of any one touch key () causes visualization of an image in a second area () of the screen, wherein the images are displayed alternatively and are at least partly different one from another, wherein each touch key () is associated to an instruction, or to a group of instructions, each concerned with readying the machine for use, wherein each image is a pictograph of a configuration of the machine, correlated with an instruction associated to the touch key () selected, and wherein the operator is aided in making the machine ready for treatment. 1. An extracorporeal blood treatment system comprising: a blood treatment unit,', 'a U-shaped tract of blood pump tubing,', 'a U-shaped tract of first infusion pump tubing,', 'a U-shaped tract of second infusion pump tubing,', 'a U-shaped tract of effluent pump tubing, and', 'a support member, wherein the blood treatment unit, the U-shaped tract of blood pump tubing, the U-shaped tract of first infusion pump tubing, the U-shaped tract of second infusion pump tubing, and the U-shaped tract of effluent pump tubing are supported by the support member; and, 'a disposable set including'} a peristaltic blood pump,', 'a first peristaltic infusion pump,', 'a second peristaltic infusion pump,', 'a peristaltic effluent pump,', the U-shaped tract of blood pump tubing with the peristaltic blood pump,', 'the U-shaped tract of first infusion pump tubing with the first peristaltic infusion pump,', 'the U-shaped tract of second infusion pump tubing with the second peristaltic infusion pump, and', 'the U-shaped tract of effluent pump tubing with the peristaltic effluent pump, and, 'a machine body supporting the peristaltic blood pump, the first peristaltic infusion pump, the ...

LASER-BASED TREATMENT FOR MALARIA

Malaria, caused by the parasite , is a devastating disease killing more than people a year worldwide. replicates within erythrocytes by digesting hemoglobin, producing haemozoin as a byproduct which accumulates within the parasite. The development of vaccines is hampered by lack of memory immune response, while the long-term effectiveness of current anti-malaria drugs is limited due to the emergence of drug-resistant strains. Furthermore, people who are deficient of the enzyme glucose 6-phosphate dehydrogenase exhibit fatally-adverse drug effects. To overcome these hurdles, I propose a novel laserbased, non-pharmacological treatment for malaria. The treatment is based on the ability of haemozoin to convert light in the near infra-red into ultra-violet (UV) radiation via Third Harmonic Generation. The UV light produced by haemozoin can in turn kill the parasite. In experiments with infected erythrocytes we obtained a 4-log reduction in parasetemia following six passes of the blood through the laser beam. 1. An apparatus comprising a pulsed near infra-red (NIR) laser and a dialysis machine equipped with a NIR transparent window for the treatment of malaria by irradiation of the infected perfused blood through the window.2. An apparatus comprising a pulsed near infra-red (NIR) laser for the treatment of malaria by irradiation of the infected blood through the patient's own skin.{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'A method comprising to treat a person infected with malaria.'}{'claim-ref': {'@idref': 'CLM-00002', 'claim 2'}, 'A method comprising to treat a person infected with malaria.'} This application claims the benefit of U.S. Provisional Patent Application No. 61/856,281 filed Jul. 19, 2013 which is incorporated herein in its entirety.Malaria is a devastating disease killing more than 800,000 people a year worldwide(1). Malaria is caused by the parasite vectored by mosquitoes. The parasite infects erythrocytes where it replicates(2). The development ...

GASEOUS FLUID PUMP

A gaseous fluid pump includes a compression chamber, a plurality of pistons, a plurality of electric coils, and a magnet. The chamber contains at least one inlet and one outlet and a plurality of open volumes created by an inner surface of the compression chamber. The plurality of pistons are within the compression chamber and each piston containing a body with at least a first diametrically polarized magnet centered in the body such that the first magnet attracts or repels depending on the relative position of the first magnet. The plurality of electric coils wound around laminations on an outside of the compression chamber with each of the plurality of electric coils configured to create flux paths centered around each of the pistons when provided electricity to act as a polarizing motor stator. A second magnet is centered within the compression chamber between two of the plurality of pistons. 1. An apparatus for pumping and compressing fluids comprising:a compression chamber, the chamber containing at least one inlet and one outlet, and a plurality of open volumes created by an inner surface of the compression chamber;a plurality of pistons within the compression chamber, each piston containing a body with at least a first diametrically polarized magnet centered in the body, such that the first magnet attracts or repels depending on the relative position of the first magnet;a plurality of electric coils wound around laminations on an outside of the compression chamber, each of the plurality of electric coils configured to create flux paths centered around each of the pistons when provided electricity to act as a polarizing motor stator; anda second magnet centered within the compression chamber between two of the plurality of pistons.2. The apparatus of wherein the compression chamber is made of glass.3. The apparatus of wherein each piston body is comprised of graphite.4. The apparatus of wherein the compression chamber contains a third magnet on a first end of ...

Smart Actuator For Valve

A system and method of monitoring and controlling the open and close states of a manifold diaphragm type valve includes using an actuator mechanism with feedback control. A pressure transducer and/or force gauge located on the contact end of the actuator mechanism monitors the pressure and/or force applied to the end of the actuator mechanism. A controller instructs the actuator mechanism to move forward or backward an appropriate distance based on the monitored pressure and/or force. Temperature and pressure changes in the system and material changes to the diaphragm are sensed immediately and positioning correction is applied to the actuator in real-time, thereby maintaining the same valve state while monitoring pressure separately. The linear actuator functions as a ‘smart’ actuator, capable of fine tune adjustments without additional outside monitoring and providing a more accurate and reliable method of closing the valve in a dynamic environment. 1. A valve actuator system adapted to open and close a valve , comprising an orifice closing member , positioned within a manifold and adjacent a fluid pathway through which fluid flows in a dialysis system , said valve actuator mechanism comprising:a displacement member adapted to being displaced linearly and having a contact end wherein said contact end is positioned proximate to said orifice closing member when said valve is in said open state;a motor for moving said displacement member;at least one pressure sensor positioned on said contact end for sensing pressure generated when said contact end is in physical communication with said orifice closing member and for relaying data based on said sensed pressure; anda controller for receiving the sensed pressure from the at least one pressure sensor, wherein said controller comprises a memory having stored therein a plurality of programmatic instructions that, when executed by a processing unit, compare said sensed pressure to a pre-determined value stored in said ...

MANAGEMENT OF INFUSION DATA METHODS AND APPARATUS

A networked patient care system includes an infusion pump communicatively coupled to a hospital network, a first server communicatively coupled to the infusion pump via the hospital network, and a second server communicatively coupled to the first server via a separate secure connection. The first server is configured to receive infusion pump data from the infusion pump and cause the second server to store the infusion pump data in an HL 7 format to an electronic patient medical record. The first server is also configured to receive a request from a display device to access the electronic patient medical record and cause the second server to convert the infusion pump data in the electronic patient medical record from the HL 7 format to a web-based format. The first server is further configured to transmit the infusion pump data in the web-based format to the display device. 1. A networked patient care system comprising:an infusion pump communicatively coupled to a hospital network and configured to perform an infusion treatment on a patient, determine infusion pump data related to the infusion treatment, and transmit the infusion pump data in an HL 7 format to the hospital network;a first server communicatively coupled to the infusion pump via the hospital network; anda second server communicatively coupled to the first server via a separate secure connection, the first server including at least one relay interface to enable display devices to access electronic patient medical records that are stored via the second server, receive the infusion pump data from the hospital network, and cause the second server to store the infusion pump data in the HL 7 format to an electronic patient medical record,', 'receive a request via the at least one relay interface from a display device to access the electronic patient medical record,', 'use the at least one relay interface to request the electronic patient medical record from the second server causing the second server to ...

Vehicle for providing a dialysis solution

The present invention relates to a power-driven land, water or air vehicle for providing dialysis solution receptacles, in particular bags, filled with dialysis solution, with the vehicle having a tank for receiving dialysis solution or for receiving a component of a dialysis solution, a storage region for the dialysis solution receptacles to be filled, and a filling station that is in fluid communication with the tank and that is configured to fill the dialysis solution receptacles with dialysis solution or with a component of the dialysis solution.

TOTAL CHLORINE WATER DETECTION SYSTEM AND METHOD FOR MEDICAL FLUID TREATMENTS

A system and method for determining a concentration of total chlorine in dialysis water are provided. The system comprises a main unit housing a KI/water sample chamber and a sodium sulfate chamber. A first electrode pair bridges the two chambers and generates tri-iodide proportional to the amount of total chlorine in the water sample. A second electrode pair in contact with fluid in the KI/water sample detects an amount of tri-iodide generated by the first electrode pair. The system is suitable for use in connection with, or for incorporation into, a water purification system for generating dialysis fluid, and may include a display that alerts the user to stop or prevent a hemodialysis treatment if the total chlorine level exceeds a predetermined level. 1. A dialysis system comprising:a water purification machine producing an at least partially purified water sample;a dialysis machine for providing dialysis therapy to a patient, the dialysis machine receiving purified water from the water purification machine; and an iodide reservoir,', 'a reducing agent reservoir,', 'a first chamber in fluid communication with the iodide reservoir and the water purification machine,', 'a second chamber in fluid communication with the reducing agent reservoir, wherein the first and second chambers are separated by a membrane that allows charge but not fluid to pass between the chambers,', 'a first electrode pair associated with a first voltage source, wherein one electrode of the first electrode pair is in contact with iodide fluid and the at least partially purified water sample mixed in the first chamber and the other electrode of the first electrode pair is in contact with a reducing agent solution in the second chamber, and', 'a second electrode pair associated with a second voltage source, wherein both electrodes of the second electrode pair are in contact with the iodide fluid and the at least partially purified water sample mixed in the first chamber., 'a chlorine detection ...

HEMODIALYSIS SYSTEM

A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly. 1. A drain cassette for a dialysis unit , comprising:a venous connection port for connection to, and fluid communication with, a venous blood line connector;an arterial connection port for connection to, and fluid communication with, an arterial blood line connector;a fluid channel fluidly connecting the venous connection port and the arterial connection port;a drain outlet port in fluid communication with the fluid channel and arranged to removably couple with a drain connector on an exposed panel of the dialysis unit; anda valve arranged to control flow in the fluid channel,wherein the valve is arranged to control in the fluid channel to either controllably open and close fluid communication in the fluid channel between the drain outlet port and the venous connection port or to controllably open and close fluid communication in the fluid channel between the drain outlet port and the arterial connection port.2. The drain cassette of claim 1 , further comprising:a body that defines the arterial and venous connection ports and the fluid channel.3. The drain cassette of claim 1 , further ...

System and method for monitoring arterial and venous blood oxygen, blood glucose, and blood constituent concentration

A system for measuring of arterial and venous blood constituent concentration based first on measuring cardiac blood flow balance parameter between the right chamber of the heart and the left chamber of the heart, which includes a sensor device for measuring one of blood pressure and blood flow rate and blood constituent concentration of a patient so as to generate an arterial pulse signal. A processing unit is responsive to the arterial pulse signal for generating full arterial pulse plethysmography waveforms, arterio-venous pulse plethysmography waveforms, and balance parameters. A computational device that is responsive to plethysmography waveforms generating a plurality of state space linear transfer functions by applying system identification between plethysmography waveforms at various wavelengths representing a plurality of models of the blood constituent concentration, including oxygen, carbon dioxide, hemoglobin, and glucose, and displaying related useful information.

PORTABLE DIALYSIS DRAINAGE SYSTEM AND METHOD

A toilet modified for disposal of dialysis waste includes a base, a bowl, a water supply port, and a dialysis drain port. In the dialysis drain port is a two piece air gap device that establishes a gap between ends of first and second drain tubes of a dialysis machine and a fluid level in the air gap. RO water and effluent from the dialysis machine enter the chamber of the air gap and mix, before being passed along a path from the dialysis drain port to the bowl of the toilet, where it can be dispelled in a sanitary manner in compliant with all pertinent codes and regulations. 1. A toilet modified for disposal of dialysis waste , comprising: a base;a bowl;a water supply port;a dialysis drain port;two piece air gap device having first and second stems affixed to the first part, a window in the first part, and a cap for closing the two piece air gap when not in use, where RO water and effluent from a dialysis operation enter the two piece air gap at the respective first and second stems, the two piece air gap device adapted to prevent any fluids from flowing back up into the first and second stems by evacuating said fluids through the window before the fluids reach the first and second stems; anda path from the dialysis drain port to the bowl of the toilet.2. The toilet of claim 1 , wherein the path from the dialysis drain port to the bowl of the toilet induces a vortex in the resulting stream.36. The toilet of claim claim 1 , wherein the RO water and effluent from the dialysis machine mix in the two piece air gap device prior to entering the path from the dialysis drain port to the bowl. This application is a continuation in part of U.S. patent application Ser. No. 15/486,552, filed Apr. 13, 2017, and further claims priority to U.S. Provisional Patent Application No. 62/539,030, filed Jul. 31, 2017, the contents of which are fully incorporated by reference herein.In humans, the kidneys have an important role in maintaining health. When healthy, the kidneys maintain ...

Adjusting Sound on a Medical Device

A dialysis machine comprising: a microphone; an alert module for producing an audible alert related to an operating condition of the dialysis machine; and a processing module configured for: receiving, from the microphone, information related to measured noise; determining, based on the information related to measured noise, an audible alert that will not be masked by the measured noise when the audible alert is produced by the alert module; and providing, to the alert module, instructions for producing the audible alert. 1. A dialysis machine comprising:a microphone;an alert module for producing an audible alert related to an operating condition of the dialysis machine; and receiving, from the microphone, information related to measured noise;', 'identifying a type of the measured noise;', 'determining, based on the information related to the measured noise and the identified type of the measured noise, an audible alert that will not be masked by the measured noise when the audible alert is produced by the alert module; and', 'providing, to the alert module, instructions for producing the audible alert., 'a processing module configured for2. The dialysis machine of claim 1 , wherein the measured noise is ambient noise.3. The dialysis machine of claim 2 , wherein the information related to the ambient noise includes a measurement of a volume of the ambient noise.4. The dialysis machine of claim 3 , wherein the instructions cause the alert module to produce an audible alert that is louder than the volume of the ambient noise.5. The dialysis machine of claim 1 , wherein the measured noise is a second audible alert.6. The dialysis machine of claim 5 , wherein the second audible alert is related to an operating condition of a second dialysis machine.7. The dialysis machine of claim 5 , wherein the information related to the second audible alert includes a measurement of a timing of the second audible alert.8. The dialysis machine of claim 7 , wherein the instructions ...

TREATING INFECTIONS WITH CEFTOLOZANE/TAZOBACTAM IN SUBJECTS HAVING IMPAIRED RENAL FUNCTION

Disclosed are methods of administering cephalosporin/tazobactam to human patients with end stage renal disease undergoing hemodialysis and suffering from a complicated intra-abdominal infection or a complicated urinary tract infection. 1. A method of treating an infection in a patient having an estimated creatinine clearance of up to about 50 mL/min , comprising administering to the patient in need thereof a dose of ceftolozane and tazobactam in a 2:1 weight ratio between ceftolozane active and tazobactam active , on two or more successive days of treatment , in amounts and at a dosing interval effective to provide at least an unbound concentration of ceftolozane of at least 8 micrograms/mL for at least 30% of the time between successive treatment days and unbound tazobactam of about 1 microgram/mL for at least 20% of the time and about 0.5 microgram/mL for about or higher than 50% of the time.2. The method of claim 1 , wherein the patient has an estimated CrCL of 15 to 29 mL/min and a total of 375 mg of the ceftolozane and tazobactam are administered every 8 hours.3. The method of claim 1 , wherein a total of 250 mg ceftolozane active and 125 mg tazobactam active is intravenously administered every 8 hours to the patient having a creatinine clearance of 15-29 ml/min for treating an infection selected from the group consisting of a complicated intra-abdominal infection (cIAI) and a complicated urinary tract infection (cUTI).5. The method of claim 4 , wherein the infection is selected from the group consisting of a complicated intra-abdominal infection (cIAI) and a complicated urinary tract infection (cUTI).6. The method of claim 5 , wherein each dose of ceftolozane and tazobactam is administered at the same or different durations of 1-4 hours each.7. The method of claim 5 , wherein each dose is administered in a 1-hour intravenous infusion.8. The method of claim 4 , further comprising doubling the dose administered after the patient receives each hemodialysis.9. The ...

Articles for Warming and Monitoring Patient During Dialysis Treatment

An article configured to warm and monitor a patient during a dialysis treatment, the article includes one or more heating elements. The article also includes one or more sensors configured to monitor a condition of the patient during the dialysis treatment. The article also includes a fabric portion configured to receive the one or more heating elements and the one or more sensors and position the one or more heating elements and the one or more sensors on the patient during treatment. The article also includes a transmitter configured to transmit information from the one or more sensors to a dialysis machine and an electrical connector configured to provide power to at least one of the one or more heating elements and the one or more sensors. 1one or more heating elements;one or more sensors configured to monitor a condition of the patient during the dialysis treatment;a fabric portion configured to receive the one or more heating elements and the one or more sensors and position the one or more heating elements and the one or more sensors on the patient during treatment;a transmitter configured to transmit information from the one or more sensors to a dialysis machine; andan electrical connector configured to provide power to at least one of the one or more heating elements and the one or more sensors.. An article configured to warm and monitor a patient during a dialysis treatment, the article comprising: This application is a continuation application of and claims priority to U.S. application Ser. No. 15/841,020, filed on Dec. 13, 2017.This disclosure relates to articles for warming and monitoring a patient during a dialysis treatment.Dialysis is a treatment used to support a patient with insufficient renal function. The two principal dialysis methods are hemodialysis and peritoneal dialysis.During hemodialysis (“HD”), the patient's blood is passed through a dialyzer of a dialysis machine while also passing a dialysis solution or dialysate through the dialyzer. ...

RECIRCULATING DIALYSATE FLUID CIRCUIT FOR BLOOD MEASUREMENT

A blood based solute monitoring system for measuring at least one blood solute species that has a first recirculation flow path in fluid communication with a dialyzer. The first recirculation flow path is configured to allow a fluid to recirculate through a dialyzer such that the concentration of at least one solute species in the fluid becomes equilibrated to the solute species concentration of the blood in a blood compartment of the dialyzer. The blood solute monitoring system has at least one sensor to measure a fluid characteristic. 1. A system , comprising:at least a first recirculation flow path;the first recirculation flow path in fluid communication with a dialyzer;the first recirculation flow path comprising at least one pump and at least one sensor measuring at least one fluid characteristic;wherein a concentration of at least one solute in a fluid recirculating in the first recirculation flow path becomes equilibrated with a concentration of the at least one solute in a blood of a patient.2. The system of claim 1 , wherein the sensor is located upstream of the dialyzer and downstream of a dialysate regeneration unit wherein the dialysate regeneration unit is fluidly connectable to the first recirculation flow path.3. The system of claim 1 , wherein the at least one sensor comprises an ion selective sensor.4. The system of claim 1 , further comprising at least two sensors to measure the at least one fluid characteristic.5. The system of claim 4 , wherein the at least two sensors include a conductivity sensor.6. The system of claim 4 , wherein the at least two sensors include any one of a potassium sensor claim 4 , a bicarbonate sensor claim 4 , and an ammonia sensor.7. The system of claim 1 , wherein the at least one sensor comprises a pH sensor.8. The system of claim 1 , wherein the at least one sensor comprises a urea sensor.9. The system of claim 1 , wherein the at least one sensor comprises a conductivity sensor.10. The system of claim 9 , further ...

MEASURING DEVICE, DIALYSIS END CONDITION DETERMINING DEVICE, AND DIALYSIS PROGRESS PRESENTING DEVICE

A measuring device () includes an analysis unit () that holds a fluid pool (B) of blood or serum therein, an irradiation unit () that irradiates fluorescent substances contained in the fluid pool (B) with excitation light, and a light receiving unit () that receives fluorescence generated from the fluorescent substances. An amount of the fluorescent substances contained in the blood or the serum after artificial dialysis is estimated from the intensity of the fluorescence. 1. A measuring device comprising:an analysis unit that holds blood or serum therein;an irradiation unit that irradiates fluorescent substances in the blood or the serum with excitation light; anda light receiving unit that receives fluorescence generated upon irradiation with the excitation light.2. The measuring device according to claim 1 , wherein the analysis unit includes an inflow port through which the blood or the serum flows in claim 1 , and has a capacity adapted to form a fluid pool of the blood or the serum when the blood or the serum is held in the analysis unit.3. The measuring device according to claim 2 , wherein the analysis unit includes a hole through which a syringe is inserted to sample the blood or the serum from the fluid pool.4. The measuring device according to claim 1 , further comprising a mechanism that obtains the serum through centrifugal separation of the blood.5. The measuring device according to claim 1 , wherein when the blood or the serum branched from a flow passage claim 1 , through which the blood or the serum flows at a first flow rate claim 1 , flows into the analysis unit claim 1 , the measuring device further comprises a regulator that decelerates the blood or the serum flowing into the analysis unit to a second flow rate.6. The measuring device according to claim 5 , wherein the second flow rate is 10 ml/min or less.7. The measuring device according to claim 1 , wherein the analysis unit is a drip chamber.8. The measuring device according to claim 1 , ...

Device and method for predicting intradialytic parameters

Devices and methods for the prognosis of intradialytic parameters such as a blood pressure are described, wherein at least one learning algorithm and/or at least one neural network is/are provided. A memory device stores patient-individual intradialytic parameters, laboratory parameters, and/or machine parameters, which can be used in the prognosis of patient-specific parameter progress during a dialysis treatment.

DETECTING PRESSURE PULSES IN A BLOOD PROCESSING APPARATUS

A monitoring device operates on a pressure signal from a blood processing apparatus which has an extracorporeal blood circuit for pumping blood through a dialyzer, and a treatment fluid supply system for pumping a treatment fluid through the dialyzer. The monitoring device has a first input block for obtaining a first pressure signal, and a second input block for obtaining a second pressure signal. An emulation block generates, as a function of the second pressure signal, an emulated first pressure signal which emulates a concurrent signal response of the first pressure sensor, and a filtering block generates a filtered signal as a function of the first pressure signal and the emulated first pressure signal, so as to suppress, in the filtered signal compared to the first pressure signal, signal interferences originating from the treatment fluid supply system. A pulse detection block processes the filtered signal for detection of subject pulses. 1: A monitoring device comprising:a first input block configured to obtain a first pressure signal (y) from a first pressure sensor, which is arranged in an extracorporeal blood circuit to detect pressure variations in blood which is pumped through a blood processing unit in the extracorporeal blood circuit by a blood pumping device, wherein the extracorporeal blood circuit is connected to a vascular system of a subject;a second input block configured to obtain a second pressure signal (u) from a second pressure sensor, which is arranged in a treatment fluid supply system to detect pressure variations in a treatment fluid which is pumped through the blood processing unit by the treatment fluid supply system;an emulation block configured to generate, as a function of the second pressure signal (u), an emulated first pressure signal (ŷ) which emulates a signal response of the first pressure sensor concurrently over a period of time of the first pressure signal of the first pressure sensor;{'sub': f', 'f, 'a filtering block ...

Recirculating dialysate fluid circuit for measurement of blood solute species

A blood based solute monitoring system for measuring at least one blood solute species that has a first recirculation flow path in communication with a dialyzer. The first recirculation flow path is configured to allow a fluid to recirculate through a dialyzer such that the concentration of at least one solute species in the fluid becomes equilibrated to the solute species concentration of the blood compartment of the dialyzer. The blood solute monitoring system has at least one sensor to measure a fluid characteristic.

ENCLOSURE FOR A PORTABLE HEMODIALYSIS SYSTEM

An enclosure for containing a portable hemodialysis unit includes a housing suitable to support components for performing hemodialysis including a dialyzer, one or more pumps to circulate blood through the dialyzer, a source of dialysate, and one or more pumps to circulate the dialysate through the dialyzer. The housing may have a front panel at which blood circuit connections and dialysate fluidic connections are located, e.g., blood line connections for patient blood access, connections for a reagent supply, dialyzer connections for both blood flow and dialysate, etc. The enclosure may also include a pair of vertical, side-by-side doors hingedly mounted to the housing. With the doors in the closed position, access to the patient access and dialysate fluidic connections may be blocked, and the doors may allow for the retention of heat in the housing suitable for disinfection during a disinfection cycle. 1. (canceled)2. An enclosure for a portable hemodialysis apparatus comprising:a housing having a front panel enclosable by a pair of vertical side-by-side doors hingedly mounted to the housing at opposite sides of the front panel, the doors being movable between open and closed positions, the open position allowing access to connections and mounting sites for a dialyzer and one or more blood pumps;the front panel separating the dialyzer and the one or more blood pumps from a dialysate section and a control section, the dialysate section configured to hold one or more dialysate pumps for connection to the dialyzer, and the control section comprising a controller configured to control the one or more blood pumps and the one or more dialysate pumps and to communicate with one or more user interfaces;wherein a first user interface of said one or more user interfaces is a graphical user interface configured for connection to the controller so that said first user interface can be placed or hung on the housing, or placed on a surface away from the housing.3. The enclosure ...

Electrical Safety Methods, Devices, and Systems for Medical Treatment Devices

Systems, methods, and devices can detect a dangerous or adverse condition or anticipated condition that indicates an undesirable amount of electric current in a patient-connected tube providing fluid to a patient. The fluid flow to the patient is stopped responsive to the detection. Stoppage of fluid flow to the patient can reduce or prevent electric current in the fluid from reaching a patient, flowing through the patient to ground, and/or continuing to flow through the patient. 1. A method for protecting a patient from an electrical source of a treatment device , comprising:connecting the patient to a treatment device by a fluid circuit in which a leakage current is induced by capacitive and/or inductive coupling of the fluid circuit with the treatment device;providing a conductive element adjacent the fluid circuit such that it is capacitively coupled to the fluid circuit, wherein the conductive element is electrically isolated from a fluid carried by said fluid circuit and the fluid carried by the fluid circuit is conductive;inducing a voltage in said conductive element and detecting a magnitude of the voltage which is responsive to the current induced by said capacitive and/or inductive coupling; andinterrupting a normal operation of the treatment device effective to reduce said leakage current in response to a detected magnitude of said voltage.2. The method of claim 1 , wherein the conductive element is adjacent a tube of said fluid circuit.3. The method of claim 2 , wherein the conductive element is a curved plate that wraps at least partly around the tube.4. The method of claim 1 , wherein the conductive element is a metal clip.5. The method of claim 1 , wherein the interrupting a normal operation includes closing a valve.6. The method of claim 1 , wherein the interrupting a normal operation includes pinching a tube of said fluid circuit to isolate fluid in one portion of the fluid circuit with fluid in another portion of the fluid circuit so that current ...

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. 1. A medical treatment system , comprising:a flow balancing fluid management element configured to pump fluid from a patient interface device during a treatment and configured to pump fluid into the patient interface device during the treatment, the flow balancing fluid management element including a synchronization mechanism that is configured to proportion flow to and from the patient interface device in a predefined ratio during the treatment;the patient interface device being a device that interfaces with a patient fluid compartment including at least one of a dialyzer, a hemofilter, a hemodiafilter, an ultrafilter, and a plasmapheresis device;a proportioning bypass channel that includes a proportioning bypass pump and configured to pump fluid to or from the patient interface device in a predefined amount that has a predefined relationship to flows in said flow balancing fluid management element so as to produce a predefined net withdrawal from, or infusion into, a patient;a controller configured to control at least the proportioning bypass pump and including a processor programmed to regulate a rate of flow through the proportioning bypass pump to achieve the predefined net withdrawal from, or infusion into, the patient; andan infusion circuit connectable to a source of fluid and including an infusion circuit pump and connected to one or both of blood lines connected to a patient access, whereinat least a portion of the infusion circuit is selectively connectable to the proportioning bypass channel such that the ...

HEMODIALYSIS SYSTEM

A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly. 182.-. (canceled)83. A drain cassette that is connectable to and disconnectable from a front panel of a dialysis unit by a user of the dialysis unit , comprising:a venous connection port for connection to, and fluid communication with, a venous blood line connector that terminates a venous line of a blood circuit assembly;an arterial connection port for connection to, and fluid communication with, an arterial blood line connector that terminates an arterial line of the blood circuit assembly;a fluid channel fluidly connecting the venous connection port and the arterial connection port;a drain outlet port in fluid communication with the fluid channel and arranged to removably couple with a drain connector on the front panel of the dialysis unit; anda valve arranged to control flow in the fluid channel,wherein the valve is arranged to control in the fluid channel to either controllably open and close fluid communication in the fluid channel between the drain outlet port and the venous connection port, or to controllably open and close fluid communication in the fluid channel between the drain ...

SYSTEM FOR REMOVING UREMIC TOXINS IN DIALYSIS PROCESSES

A method of performing dialysis includes: recirculating a dialysis fluid from a patient or a dialyzer for at least two cycles, each cycle contacting the dialysis fluid first with a zirconium phosphate layer followed by at least one of a urease layer, a zirconium oxide layer, or a carbon layer; storing the recirculated dialysis fluid in a storage container; and transferring the dialysis fluid from the storage container to the patient or the dialyzer. In one example, the zirconium phosphate layer and the at least one of the urease layer, the zirconium oxide layer, or the carbon layer is provided by a sorbent cartridge. 1. A method of performing dialysis comprising:recirculating a dialysis fluid from a patient or a dialyzer for at least two cycles, each cycle contacting the dialysis fluid first with a zirconium phosphate layer followed by at least one of a urease layer, a zirconium oxide layer, or a carbon layer;storing the recirculated dialysis fluid in a storage container; andtransferring the dialysis fluid from the storage container to the patient or the dialyzer.2. The method of claim 1 , which includes operating valves to alternate between a cleaning cycle and a storing cycle.3. The method of claim 1 , wherein each cycle contacts the dialysis fluid first with a zirconium phosphate layer claim 1 , followed by a urease layer claim 1 , followed by at least one of a second zirconium phosphate layer claim 1 , a zirconium oxide layer claim 1 , and a carbon layer.4. The method of claim 3 , wherein each cycle contacts the dialysis fluid first with a zirconium phosphate layer claim 3 , followed by a urease layer claim 3 , followed by a second zirconium phosphate layer claim 3 , followed by a zirconium oxide layer claim 3 , followed by a carbon layer.5. The method of claim 1 , wherein the zirconium phosphate layer and the at least one of the urease layer claim 1 , the zirconium oxide layer claim 1 , or the carbon layer is provided by a sorbent cartridge.6. A method of ...

SUBCUTANEOUS VASCULAR ACCESS PORTS AND RELATED SYSTEMS AND METHODS

Ports for accessing a vessels within a patient include passageways that can guide needles or other access devices directly into the vessels. The ports can be implanted subcutaneously within a patient. Some ports may be used in the creation and use of vascular access buttonholes. 1positioning an access port adjacent to a wall of the vessel, the access port comprising an implantation passageway and a guidance passageway that is connected to the implantation passageway, wherein, during said positioning of the access port, the implantation passageway is open at a position proximal to a location at which the implantation passageway and the guidance passageway are connected;forming an opening in the wall of the vessel via instruments that extend through the implantation passageway;securing the access port to the vessel such that the implantation passageway is in fluid communication with an interior of the vessel via the opening in the wall of the vessel; andsealing the implantation passageway at the position proximal to the guidance passageway.. A method of securing an access port to a vessel, the method comprising: This application is a continuation of U.S. patent application Ser. No. 14/792,486, filed on Jul. 6, 2015, titled METHODS FOR IMPLANTING SUBCUTANEOUS VASCULAR ACCESS PORTS, which is a continuation of U.S. patent application Ser. No. 12/697,192, filed on Jan. 29, 2010, titled SUBCUTANEOUS VASCULAR ACCESS PORTS AND RELATED SYSTEMS AND METHODS, corresponding to U.S. Pat. No. 9,072,880, which claims the benefit under 35 U.S.C. § 119(e) of U.S. Provisional Patent Application No. 61/148,372, titled VASCULAR ACCESS METHODS, APPARATUS AND SYSTEMS, filed on Jan. 29, 2009, and of U.S. Provisional Patent Application No. 61/229,023, titled SURGICALLY IMPLANTED DIRECT VASCULAR ACCESS PORT METHOD AND APPARATUS, filed on Jul. 28, 2009, the entire contents of each of which are hereby incorporated by reference herein.The invention was made with support from the U.S. Government ...

SIMULTANEOUS ECMO AND CRRT

A controller for controlling an apparatus comprising a blood pump, oxygenator, and blood filtering system connected together by blood flow tubing and to a patient to circulate blood from the patient through the apparatus and back to the patient, to oxygenate and filter the blood, the controller comprising at least one communication interface operable to receive signals generated responsive to monitored parameters characterizing blood flow and/or quality of blood from the patient circulating through the apparatus and configured to: determine values for the monitored parameters based on the monitoring signals; determine whether or not a value determined for a given monitored parameter for blood circulating through the apparatus is within a normative range for the parameter; and generate an alarm to alert an operator of the system if the value is not within the normative range. 1. A controller for controlling an apparatus comprising a blood pump , oxygenator , and blood filtering system connected together by blood flow tubing configured to circulate blood from a patient through the apparatus and back to the patient , to oxygenate and filter the blood , the controller comprising:at least one communication interface operable to receive wireless and/or wire monitoring signals generated responsive to monitored parameters characterizing blood flow and/or quality of blood from the patient circulating through the apparatus at locations in and outside of the blood filtering system;a memory comprising a database having data that defines normative ranges for values of the monitored parameters; anda processor comprising computer executable instructions executable to:determine values for the monitored parameters based on the monitoring signals;determine whether or not a value determined for a given monitored parameter for blood circulating through the apparatus is within the normative range for the parameter; andgenerate an alarm if the value is not within the normative range.2. ...

SYSTEMS AND METHODS FOR INCORPORATING PATIENT PRESSURE INTO MEDICAL FLUID DELIVERY

Systems and methods are disclosed for incorporating patient pressure into medical fluid delivery. An example system includes a medical fluid delivery machine and a medical fluid handling device including a patient line for being placed in fluid communication with a patient. The medical fluid delivery machine includes a control unit, a pump actuator for actuating the medical fluid handling device to move medical fluid into or out of the device, and a pressure sensor configured to sense a pressure of the medical fluid. The control unit is programmed to perform a routine during pumping in which the control unit determines if at least a component of a signal reading from the pressure sensor is indicative of a pressure within the patient, and determines from the component of the signal reading indicative of the pressure in the patient whether to continue pumping or stop pumping. 1. A medical fluid delivery system comprising:a medical fluid handling device including a patient line for being placed in fluid communication with a patient; and{'claim-text': ['a pump actuator for actuating the medical fluid handling device to move medical fluid into or out of the device,', 'a pressure sensor positioned and arranged within the medical fluid handling device and configured to sense pressure of the medical fluid, and', {'claim-text': ['(i) determines if at least one signal reading or a component of the at least one signal reading from the pressure sensor is indicative of a pressure within the patient, and (ii)', 'determines from the at least one pressure signal reading or component reading indicative of the pressure in the patient whether to continue pumping or stop pumping.'], '#text': 'a control unit in signal communication with the pressure sensor and control communication with the pump actuator, the control unit programmed to perform a routine during pumping in which the control unit'}], '#text': 'a medical fluid delivery machine including'}2. The medical fluid delivery system ...

CASSETTE MODULE HAVING AN INTEGRATED CENTRIFUGAL PUMP UNIT

The invention relates to a cassette module for processing blood and therapeutic fluids in an extracorporeal blood treatment, dialysis or infusion technology, comprising a base body (), with a first side and a second side, fluid channels integrated into the base body, a receiving unit () to receive a centrifugal pump means for delivering fluids, characterized in that at least some of the fluid channels are arranged on a first side of the base body, and the receiving unit for the centrifugal pump means is arranged on the second side, and the receiving unit for the centrifugal pump means is in fluid connection with the fluid channels on the first side during operation. 1. A cassette module for processing blood and therapeutic fluids in an extracorporeal blood treatment , dialysis or infusion technology , comprising:{'b': 202', '302', '402', '502', '602', '702', '802', '902', '1002, 'a base body (, , , , , , , , ) having a first side and a second side,'}{'b': 207', '207', '307', '307', '407', '407', '507', '507', '607', '707', '707', '907', '907', '1007', '1007, 'i': a', 'a', 'a', 'a', 'a', 'a', 'a, 'fluid channels (, , , , , , , , , , , , , , ) integrated into the base body,'}{'b': 204', '304', '404', '504', '704', '804', '904', '1004, 'a receiving unit (, , , , , , , ) for receiving a centrifugal pump means for delivering fluids,'}characterized in that at least some of the fluid channels are arranged on a first side of the base body, and the receiving unit for the centrifugal pump means is arranged on a second side, and the receiving unit for the centrifugal pump means is in fluid connection with the fluid channels on the first side during operation.220720730730740740750750760770770790790710071007aaaaaaa. The cassette module according to claim 1 , characterized in that the fluid channels ( claim 1 , claim 1 , claim 1 , claim 1 , claim 1 , claim 1 , claim 1 , claim 1 , claim 1 , claim 1 , claim 1 , claim 1 , claim 1 , claim 1 , ) on the first side of the base body form ...

METHOD OF DETERMINING THE PRESSURE IN AN EXTRACORPOREAL CIRCUIT

The present invention relates to a method of determining the pressure or of a parameter correlated with the pressure in an extracorporeal circuit of a blood treatment apparatus, in particular of a dialyzer, wherein at least one blood pump which is driven by at least one motor is located in the blood circuit, wherein the motor current of the named motor and the blood flow or a parameter correlated therewith is measured for determining the pressure or the parameter correlated therewith and wherein the pressure p or the parameter correlated therewith is calculated from the measured values. 14. A method of determining the pressure p or of a parameter correlated with the pressure p in an extracorporeal circuit of a blood treatment apparatus , in particular of a dialyzer , wherein at least one blood pump () which is driven by at least one electric motor (M) is located in the blood circuit , characterized in that the motor current Iof the named motor (M) and the blood flow Qor a parameter correlated therewith is measured for determining the pressure p or the parameter correlated therewith and wherein the pressure p or the parameter correlated therewith is calculated from the measured values.244. A method in accordance with claim 1 , characterized in that using the method the pressure difference Δp is determined upstream and downstream of the blood pump (); the press pis determined upstream of the blood pump and the pressure p of the blood pump ().344. A method in accordance with claim 1 , characterized in that the parameter correlated with the blood flow Qis the speed n of the blood pump () and/or the angular speed ω of the blood pump ().44. A method in accordance with claim 1 , characterized in that the pressure difference Δp is determined upstream and downstream of the pump () in accordance with the formula I=a+b*Q+c*Q*Δp.54. A method in accordance with claim 1 , characterized in that the pressure pis determined downstream of the blood pump () in accordance with the ...

BLOOD TREATMENT APPARATUS INCLUDING FLOW DIVIDER FOR LIMITING AN ELECTRICAL CURRENT

A blood treatment apparatus comprising: a blood treatment unit; a blood line configured to extract blood from a blood source, pass the blood through the blood treatment unit and deliver treated blood to a target vessel; and a fluid line configured pass treatment fluid through the blood treatment unit and deliver used treatment fluid to a fluid sink. A flow divider is arranged in the fluid line separates treatment fluid into to a first fluid section and a second fluid section, thereby electrically isolating the fluid sections such that electrical current flowing in the fluid line between the fluid sections is limited. Related manufacturing and verification methods are also described. 1. A blood treatment apparatus comprising:a blood treatment unit;a blood line positioned and arranged to pass blood through the blood treatment unit;a fluid line in fluid communication with the blood treatment unit, the fluid line positioned and arranged to carry an electrically conductive treatment fluid;a flow divider arranged in the fluid line, the flow divider configured to separate the electrically conductive treatment fluid into a first fluid section and a second fluid section, such that the first fluid section is electrically isolated from the second fluid section by the flow divider; anda control unit configured to determine a value corresponding to an electrical current flowing between the first and second fluid sections, and if the value exceeds a predetermined value, initiate a defined action.2. The blood treatment apparatus of claim 1 , wherein the flow divider includes (i) a drip chamber structurally modified to create the first and second fluid sections or (ii) a peristaltic pump structurally modified to create the first and second fluid sections.3. The blood treatment apparatus of claim 1 , wherein the fluid line extends to a fluid sink and the electrically conductive treatment fluid is used treatment fluid.4. The blood treatment apparatus of claim 1 , wherein the control ...

Voice Interface for a Dialysis Machine

A dialysis system, comprising: a dialysis machine; an authentication component configured to determine that a source of a voice command received by the dialysis system is an authorized user of the dialysis system; and a processor configured to carry out a function determined based on the voice command.

Voice Interface for a Dialysis Machine

A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a microphone and a component that provide voice recognition capabilities to the machine. For example, in some implementations, the component is configured to identify and/or authenticate voice commands that are issued by a user. The voice command may cause the dialysis machine to carry out a dialysis function. Alternatively, the voice command may cause a user interface of the dialysis machine (e.g., a display, such as a touchscreen display) to be adjusted. A dialysis machine can also include a speaker for providing spoken information to a user. For example, in some implementations, the speaker can provide spoken instructions to assist the user in machine set-up, calibration, and/or operation. Such spoken instructions can be particularly useful in a home dialysis setting. In some implementations, the speaker can provide spoken alarms that are related to alarm conditions. 1. A dialysis system , comprising:a dialysis machine;an authentication component configured to determine that a source of a voice command received by the dialysis system is an authorized user of the dialysis system; anda processor configured to carry out a function determined based on the voice command.2. The dialysis system of claim 1 , comprising:a voice recognition component configured to identify the voice command in audio information received by a microphone.3. The dialysis system of claim 1 , wherein the voice command comprises a command for the dialysis machine to perform a dialysis function.4. The dialysis system of claim 1 , wherein audio information from which the voice command is identified is received by the dialysis system from an external device.5. The dialysis system of claim 4 , wherein the external device comprises a microphone.6. The dialysis system of claim 2 , wherein the dialysis system comprises the microphone.7. The dialysis system of claim 1 , wherein the authentication component is configured to receive ...

SYSTEMS AND METHODS FOR TREATING BLOOD

According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to pump blood in a fluid flow path at a collective rate over 5 liters per minute. The system may include one or more heat exchangers operable to heat at least a portion of the blood to a temperature of at least 42 degrees Celsius and to allow the blood to cool one or more degrees following heating. The system may include one or more convection dialysis modules configured to perform convection dialysis on at least a portion of the blood at least after the one or more heat exchangers allow the blood to cool one or more degrees. 174-. (canceled)75. A method for treating cancer , comprising:heating a human body to a core temperature between 42 and 43.2 degrees Celsius, wherein blood from the human body is flowing outside of the human body in a fluid flow path; andremoving carbon dioxide from at least a portion of the blood flowing in the fluid flow path.76. The method of claim 75 , further comprising adding oxygen to at least a portion of the blood.77. The method of claim 75 , wherein carbon dioxide is removed from at least a portion of the blood by causing at least a portion of the blood to flow through at least one membrane.78. The method of claim 77 , wherein the at least one membrane collectively has an effective surface area greater than 1.8 square meters.79. The method of claim 75 , further comprising causing the production of reactive oxygen species within the human body by adding a substance to at least a portion of the blood outside of the human body.80. The method of claim 75 , further comprising performing convection dialysis on at least a portion of the blood at a rate between 0.5 and 1.8 liters per minute.81. The method of claim 75 , further comprising pumping blood from the human body into the fluid flow path at a rate between 4 and 7 liters per minute.82. The method of claim 75 , wherein the blood is pumped in the ...