SYSTEMS AND METHODS FOR COLLECTING INSURANCE-RELATED DATA

Systems and methods are disclosed herein for collecting and processing auto insurance claim-related data. Initial data is collected from a customer or a third party appraiser via a user interface. The initial data is used to retrieve relevant compliance guideline and policy information, which is used to modify and/or populate fields in the user interface. Collected and/or retrieved information is then stored and/or used to adjust an insurance claim workflow process. 1. A system for managing an auto insurance claim workflow for a claims department with a plurality of claims processing applications , comprising:a first data store storing auto insurance compliance guidelines for a plurality of jurisdictions;a second data store storing policy data for a plurality of auto insurance policies; and output an auto insurance data collection user interface containing at least one data field requesting information about an auto insurance claim for display on a display device;', 'receive first data associated with the auto insurance claim via the user interface;', 'retrieve auto insurance compliance guidelines applicable to the claim from the first data store, based on the first data;', 'modify the user interface by at least one of adding additional data fields or removing data fields based on the retrieved auto insurance compliance guidelines and the first data;', 'retrieve policy data applicable to the claim from the second data store, based on the first data;', 'populate data fields included in the user interface with the retrieved policy data;', 'output the first data, and, 'a processor configured to use a first of the claims processing applications touse a second of the claims processing applications to retrieve data representative of at least a portion of the first data output by the first claims processing application.2. The system of claim 1 , wherein the policy data comprises at least one of policy holder data claim 1 , claim data claim 1 , and policy provision data.3. ...

System and Method for Managing Leases of Property

An equipment recovery system receives data relating to leased property and associated lease accounts. The system provides lessees with interactive messages that enable them to make payments or payment commitments. Lessees may also make arrangements to return the property or surrender them to retrieval agents. Messages may be left for lessees, enabling them to contact the system or a call center to remedy delinquent payments or arrange return of the property. The system sends interactive messages to agents of lessors enabling them to: check delinquency or payment status; accept payments; make arrangements for the retrieval of the property; or report the outcome of a retrieval attempt. Contact between the system and either the lessee or the agent may be recorded and data received may be stored and reported. 1. A system for managing one or more leases and one or more articles of lease property between lessors and lessees , the system comprising:a processing unit;a data storage medium, operatively coupled with the processing unit, configured to at least temporarily store lease data associated with the one or more leases and one or more articles of lease property;means for accessing a communications network operatively coupled with the processing unit; andat least one computer readable medium operatively coupled with the processing unit and the data storage medium; the at least one computer readable medium comprising software configured to:receive lease data that includes: (i) names and contact information for one or more lessees; (ii) information relating to lease property subject to the one or more leases; (iii) information relating to debt owed by the one or more lessees pursuant to terms of the one or more leases; and (iv) information relating to one or more lessors or lessor agents;filter the lease data, according to pre-defined parameters, selecting lessees to be contacted;initiate contact with selected lessees over the communications network;query lessees about a ...

TWIST-LOCK, BOLTLESS FIXED SCROLL-TO-FRAME JOINT

A scroll compressor and methods of assembling the scroll compressor are disclosed. The scroll compressor includes a frame aligned about a longitudinal axis of the scroll compressor, the frame including a plurality of extensions extending radially from the longitudinal axis, the plurality of extensions including axially extending frame interlock mechanisms. A fixed scroll support is aligned about the longitudinal axis, the fixed scroll support including a plurality of extensions extending radially from the longitudinal axis, the plurality of extensions including axially extending fixed scroll support interlock mechanisms configured to engage the frame interlock mechanisms upon radial rotation. A fixed scroll wrap is integral with or attached to the fixed scroll support. 1. A scroll compressor , comprising:a shell;a frame aligned about a longitudinal axis of the scroll compressor, the frame being fitted into the shell;a fixed scroll having a fixed scroll wrap and a fixed scroll support, wherein the fixed scroll support is aligned about the longitudinal axis and is secured to the frame in a boltless connection; andan intermediate cap engaging with a surface of the fixed scroll support on an opposite side of the fixed scroll wrap, the intermediate cap being secured to the shell and contacting an annular region of the fixed scroll support to bias the fixed scroll against the frame.2. The scroll compressor of claim 1 , wherein the frame includes a plurality of extensions extending radially from the longitudinal axis claim 1 , the plurality of extensions including axially extending frame interlock mechanisms; andthe fixed scroll support includes a plurality of extensions extending radially from the longitudinal axis, the plurality of extensions including axially extending fixed scroll support interlock mechanisms configured to engage the frame interlock mechanisms upon radial rotation.3. The scroll compressor of claim 2 , wherein at least one of the plurality of frame ...

Inflatable Imbibed Polymer Devices

The present invention provides a stretchable material suitable for use in an inflatable medical device. The stretchable material has at least one reinforcing polymer layer with a top and bottom side forming a porous matrix which is imbibed with a sealing material to infiltrate and substantially seal spaces of the porous matrix and extend beyond the reinforcing polymer layer to form a surface coating. 1. A stretchable material comprising a reinforcing polymer having a porous matrix with void spaces and a sealing material imbibed into the reinforcing polymer substantially sealing the porous matrix void spaces and extending beyond the reinforcing polymer matrix to form a surface coating.2. The stretchable material of wherein the surface coating possesses a greater strain capability than the sealing material.3. The stretchable material of wherein the sealing material is an elastomer.4. The stretchable material of wherein the sealing material is a nylon.5. The stretchable material of wherein the sealing material is a polyether block amide.6. The stretchable material of wherein the sealing material is a fluoropolymer.7. The stretchable material of wherein the polymer matrix is anisotropic material stretched in only one direction.8. The stretchable material of wherein the polymer matrix is isotropic.923-. (canceled) The present invention relates to a unique material suited for use in balloon catheters and, more particularly, to a low profile non-shortening wrapped balloon configured to expand to a predetermined diameter upon application of a predetermined pressure thereto. The unique properties of the material of the present invention enable wrapped balloons to be made without the use of internal bladders.Balloon catheters are well known in the art. Such catheters are employed in a variety of medical procedures, including dilation of narrowed blood vessels, placement of stents and other implants, temporary occlusion of blood vessels, and other vascular uses.In a typical ...

Method and System for Characterizing an Array Antenna Using Near-Field Measurements

Near field array antenna calibration is performed using multiple probe element locations within the near field of an array antenna for each element of the array. 1. A method for calibrating an array antenna using near-field antenna measurements , the method comprising:for a first antenna element in an antenna under test (AUT), obtaining a received signal for each of multiple known probe locations in a near-field of the AUT;combining the received signals to generate a combined signal for the first antenna element, wherein combining the received signals includes combining the signal in a manner that de-correlates multi-path in the combination result; andprocessing the combined signal to generate a calibration coefficient for the first AUT antenna element.2. The method of claim 1 , wherein:obtaining a received signal for each of multiple known probe locations in a near-field of the AUT includes obtaining a measurement of a received signal; andcombining the received signals to generate a combined signal for the first antenna element includes combining measurements of received signals in a virtual manner to generate a combined measurement.3. The method of claim 1 , further comprising:repeating obtaining, combining, and processing for other AUT antenna elements to generate calibration coefficients for the other AUT antenna elements.4. The method of claim 1 , whereinobtaining, combining, and processing are performed for a first calibration frequency within an operational bandwidth of the AUT; andthe method further comprises repeating obtaining, combining, and processing for the first AUT antenna element for other calibration frequencies across an operational bandwidth of the AUT.5. The method of claim 1 , wherein:obtaining, combining, and processing are performed for a first polarization state associated with the first AUT antenna element; andthe method further comprises repeating obtaining, combining, and processing for at least one other polarization state associated ...

Single Pass Dialysis Combined with Multiple Pass Albumin Dialysis

Methods, systems, and devices are disclosed, embodiments of which provide single pass dialysis to remove water and uremic toxins is performed simultaneously with the albumin dialysis therapy by passing the albumin solution through a dialysis filter which dialyses it before the solution is returned to the cycler. In embodiments, the single pass dialysis stage is upstream of the albumin filtering stage. 1. A method for simultaneously performing liver dialysis that clears albumin-bound molecules from blood and kidney dialysis that clears solutes from blood , the method comprising:providing a medical treatment cycler that includes a first pump and a second pump, the medical treatment cycler being configured to balance a medical treatment fluid flowing into the medical treatment cycler and the medical treatment fluid flowing out of the medical treatment cycler and adapted to provide a selectable difference between ingoing and outgoing flows of the medical treatment fluid;connecting the medical treatment cycler to a predefined disposable tubing set that includes a first filter, a fluid inlet connector, and a fluid outlet connector;providing a supplemental fluid management system configured to clear solutes from a solution received at the fluid outlet connector and to supply solute-cleared fluid to the fluid inlet connector, the supplemental fluid management system having a second filter;connecting the supplemental fluid management system to the fluid inlet connector and the fluid outlet connector of the predefined disposable tubing set;selecting the selectable difference between the ingoing and outgoing flows;controlling the first pump to operate at a first fluid flow rate;controlling the second pump to operate at a second fluid flow rate that differs from the first fluid flow rate by the selectable difference;circulating an albumin solution in the predefined disposable tubing set;clearing solutes from the albumin solution using the supplemental fluid management system; ...

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. 1. A medical treatment system , comprising:a flow balancing fluid management element configured to pump fluid from a patient interface device during a treatment and configured to pump fluid into the patient interface device during the treatment, the flow balancing fluid management element including a synchronization mechanism that is configured to proportion flow to and from the patient interface device in a predefined ratio during the treatment;the patient interface device being a device that interfaces with a patient fluid compartment including at least one of a dialyzer, a hemofilter, a hemodiafilter, an ultrafilter, and a plasmapheresis device;a proportioning bypass channel that includes a proportioning bypass pump and configured to pump fluid to or from the patient interface device in a predefined amount that has a predefined relationship to flows in said flow balancing fluid management element so as to produce a predefined net withdrawal from, or infusion into, a patient;a controller configured to control at least the proportioning bypass pump and including a processor programmed to regulate a rate of flow through the proportioning bypass pump to achieve the predefined net withdrawal from, or infusion into, the patient; andan infusion circuit connectable to a source of fluid and including an infusion circuit pump and connected to one or both of blood lines connected to a patient access, whereinat least a portion of the infusion circuit is selectively connectable to the proportioning bypass channel such that the ...

ANTIBODIES AGAINST CD73 AND USES THEREOF

The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers. 162-. (canceled)63. A method of decreasing adenosine levels in a tumor of a human subject , comprising administering to the subject an antibody , or antigen binding portion thereof , that binds to human CD73 , wherein the antibody , or antigen binding portion thereof , comprises a heavy chain comprising CDR1 , CDR2 , and CDR3 sequences comprising the amino acid sequences of SEQ ID NOs: 5 , 6 , and 7 , respectively , and a light chain comprising CDR1 , CDR2 , and CDR3 sequences comprising the amino acid sequences of SEQ ID NOs: 13 , 14 , and 15 , respectively.64. A method of stimulating an immune response against a tumor in a human subject in need thereof , comprising administering to the subject an effective amount of an antibody , or antigen binding portion thereof , that binds to human CD73 , wherein the antibody , or antigen binding portion thereof , comprises a heavy chain comprising CDR1 , CDR2 , and CDR3 sequences comprising the amino acid sequences of SEQ ID NOs: 5 , 6 , and 7 , respectively , and a light chain comprising CDR1 , CDR2 , and CDR3 sequences comprising the amino acid sequences of SEQ ID NOs: 13 , 14 , and 15 , respectively.65. A method of stimulating an immune response in a human subject comprising ...

PROACTIVELY CLEARING DIGITAL STORAGE

A device may monitor an amount of storage available on a user device; determine, based on the monitoring, that the amount of storage is below a particular threshold; score multiple data files stored by the user device; determine particular data files, of the multiple data files, that should be deleted from the user device based on the scoring and based on the amount of storage available on the user device; and cause, based on determining that the amount of storage is below the particular threshold, the user device to delete the particular data files from the user device. The user device may have an amount of available storage space exceeding the particular threshold after deleting the particular data files. 1. A method comprising:scoring, by a device, a plurality of data files stored by a user device;monitoring, by the device, an amount of storage available on the user device;determining, by the device and based on the monitoring, that the amount of storage is below a particular threshold;selecting, by the device, particular data files, of the plurality of data files, that should be deleted from the user device based on the scoring and based on the amount of storage available on the user device; and 'the user device having an amount of available storage space exceeding the particular threshold after deleting the particular data files.', 'causing, by the device and based on determining that the amount of storage is below the particular threshold, the user device to delete the particular data files from the user device,'}2. The method of claim 1 , wherein scoring the data files includes combining values associated with attributes of the data files.3. The method of claim 2 , wherein the attributes of one of the data files include at least one of:contents of the data file,metadata associated with the data file,a measure of quality of the data file, ora rating associated with the data file.4. The method of claim 1 , wherein causing the user device to delete the ...

ANTIBODIES AGAINST CD73 AND USES THEREOF

The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers. 18-. (canceled)9. A method of decreasing adenosine levels in a tumor of a human subject , comprising administering to the subject an antibody that binds to human CD73 , wherein the antibody comprises a heavy chain comprising CDR1 , CDR2 , and CDR3 sequences comprising the amino acid sequences of SEQ ID NOs: 5 , 6 , and 7 , respectively , and a light chain comprising CDR1 , CDR2 , and CDR3 sequences comprising the amino acid sequences of SEQ ID NOs: 13 , 14 , and 15 , respectively.10. A method of stimulating an immune response against a tumor in a human subject in need thereof , comprising administering to the subject an effective amount of an antibody that binds to human CD73 , wherein the antibody comprises a heavy chain comprising CDR1 , CDR2 , and CDR3 sequences comprising the amino acid sequences of SEQ ID NOs: 5 , 6 , and 7 , respectively , and a light chain comprising CDR1 , CDR2 , and CDR3 sequences comprising the amino acid sequences of SEQ ID NOs: 13 , 14 , and 15 , respectively.11. A method of stimulating an immune response in a human subject , comprising administering to the subject an antibody that binds to human CD73 , wherein the antibody comprises a heavy chain comprising CDR1 , CDR2 , and CDR3 sequences ...

SUSTAINED RELEASE COMPOSITIONS OF 4-AMINOPYRIDINE

The present invention generally relates to sustained release 4-aminopyridine tablets, which include a core and a coating. The sustained release tablets of the invention are generally suitable for once daily oral administration for the treatment of neurological disorders. 1. A sustained release tablet comprising:(a) a compressed core, said compressed core comprising 4-aminopyridine, a polyethylene oxide with a molecular weight between about 1,000,000 and 10,000,000, and a mixture comprising polyvinyl acetate and polyvinyl pyrrolidone; and(b) an amount of an ethylcellulose coat surrounding said compressed core, said amount of the ethylcellulose coat being in the range of about 5% w/w to about 10% w/w of the compressed core.2. The sustained release tablet of claim 1 , wherein said mixture further comprises one or more pharmaceutically acceptable excipients.3. The sustained release tablet of claim 1 , wherein said mixture comprises 70-90% polyvinyl acetate and 15-20% polyvinyl pyrrolidone.4. The sustained release tablet of any of - claim 1 , wherein said mixture further comprises a surfactant.5. The sustained release tablet of claim 4 , wherein said mixture further comprises silica.6. The sustained release tablet of any of - claim 4 , wherein said mixture consists of about 80% polyvinyl acetate claim 4 , about 19% polyvinyl pyrrolidone claim 4 , about 0.8% sodium lauryl sulfate claim 4 , and about 0.2% silica.7. The sustained release tablet of any of - claim 4 , wherein the compressed core further comprises a filler and a lubricant.8. The sustained release tablet of claim 7 , wherein the filler is dibasic calcium phosphate dihydrate claim 7 , and the lubricant is magnesium stearate.9. The sustained release tablet of any of - claim 7 , wherein the polyethylene oxide has a molecular weight between 4 claim 7 ,000 claim 7 ,000 and 8 claim 7 ,000 claim 7 ,000.10. The sustained release tablet of any of - claim 7 , wherein the polyethylene oxide has a molecular weight of 7 ...

Fluid Purification Methods, Devices, and Systems

A fluid purification system has cells whose purifying capability can be regenerated. Some of the cells are arranged in series to reach a high level of purification. An automatic valve network is controlled to cycle the cells in a way that levels the loads on each, thereby maximizing the service interval for replacing expired cells, enabling all of the cells to be replaced at the same time after having each contributing approximately equally to the purification load, and operated such that at any one time, at least one cell is regenerated so as to enable continuous up-time. 1. A system for purifying water , comprising:a fluid circuit with source water and product water ports, fluid channels, automatic valves (AVs), electronic deionization cell modules (EDCs), and a controller connected to control the AVs and the EDCs, each AV having an inlet and an outlet;the controller being configured to operate the AVs to define selected flow paths to carry water through the EDCs in series corresponding to respective selected flow paths whereby the EDCs fall irank Ns with an AV receiving water from the source water port having a lowest rank in the series (0), the EDC ranks increasing along the series, and an EDC supplying water to the product water port having a highest rank in the series (N); andthe controller being configured to operate the AVs periodically to define the flow paths to flow a first portion of water from the rank N−1 AV outlet to the product water port and a second portion in a reverse direction (outlet to inlet) to regenerate said the rank N AV, andthe controller further being configured to perform a rotation operation that operates the AVs such that a previous 0 rank AV is assigned to rank N is regenerated and each I rank AV is assigned to rank I−1, respectively.2. The system of claim 1 , wherein the controller is configured to repeat the rotation operation.3. The system of claim 2 , wherein claim 2 , in the rotation operations claim 2 , each EDC takes more than ...

AUTOMATED IMAGE ORGANIZATION TECHNIQUES

A device may receive multiple images captured by a user device; and determine an event based on at least one of: attributes of the multiple images, information regarding a user associated with the multiple images, or information regarding the user device. The device may determine attributes of the event; identify, based on the attributes of the multiple the images and the attributes of the event, particular images, of the multiple images, associated with the event; generate a digital image album that includes one or more of the particular images; and output the digital image album. 1. A method comprising:receiving, by a device, a plurality of images captured by a user device; attributes of the plurality of images,', 'information regarding a user associated with the plurality of images, or', 'information regarding the user device;, 'determining, by the device, an event based on at least one ofdetermining, by the device, attributes of the event;identifying, by the device and based on the attributes of the plurality of the images and the attributes of the event, particular images, of the plurality of images, associated with the event;generating, by the device, a digital image album that includes one or more of the particular images; andoutputting, by the device, the digital image album.2. The method of claim 1 , wherein determining the event includes determining the event based on at least one of:the attributes of the plurality of images,the information regarding a user associated with the images, orthe information regarding the user device.3. The method of claim 1 , wherein the one or more particular images are selected based on:scores for each of the one or more particular images, the scores being based on attributes of the one or more particular images.4. The method of claim 1 , wherein the attributes of a particular image claim 1 , of the plurality of images claim 1 , includes at least one of:information identifying text pictured in the particular image,information ...

SUSTAINED RELEASE COMPOSITIONS OF 4-AMINOPYRIDINE

The present invention generally relates to sustained release 4-aminopyridine tablets, which include a core and a coating. The sustained release tablets of the invention are generally suitable for once daily oral administration for the treatment of neurological disorders. 2. The sustained release tablet of claim 1 , wherein upon once daily oral administration to a human subject in a fasted state claim 1 , the sustained release tablet provides the following pharmacokinetic parameters: (a) a mean steady state plasma 4-aminopyridine Cin the range of about 18.61 ng/mL to about 37.19 ng/mL claim 1 , (b) a mean steady state plasma 4-aminopyridine Cin the range of about 7.73 ng/mL to about 19.47 ng/mL claim 1 , and (c) a median steady state plasma 4-aminopyridine Tin the range of about 3 h to about 12 h.3. The sustained release tablet of claim 1 , wherein upon once daily oral administration to a human subject in a fasted state claim 1 , the sustained release tablet provides a mean steady state plasma 4-aminopyridine Cin the range of about 18.61 ng/mL to about 37.19 ng/mL.4. The sustained release tablet of claim 1 , wherein upon once daily oral administration to a human subject in a fasted state claim 1 , the sustained release tablet provides a mean steady state plasma 4-aminopyridine Cin the range of about 7.73 ng/mL to about 19.47 ng/mL.5. The sustained release tablet of claim 1 , wherein upon once daily oral administration to a human subject in a fasted state claim 1 , the sustained release tablet provides a median steady state plasma 4-aminopyridine Tin the range of about 3 h to about 12 h.7. The sustained release tablet of claim 6 , wherein upon once daily oral administration to a human subject in a fasted state claim 6 , the sustained release tablet provides the following pharmacokinetic parameters: (a) a mean steady state plasma 4-aminopyridine Cin the range of about 13.96 ng/mL to about 27.89 ng/mL claim 6 , (b) a mean steady state plasma 4-aminopyridine Cin the ...

ANTIBODIES AGAINST CD73 AND USES THEREOF

The present disclosure provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the disclosure, including methods for treating various cancers. 162-. (canceled)63. An isolated antibody , or antigen binding portion thereof , that binds to human Cluster of Differentiation 73 (CD73) , and comprises a heavy chain comprising CDR1 , CDR2 , and CDR3 sequences comprising the amino acid sequences of SEQ ID NOs: 5 , 6 , and 7 , respectively , and a light chain comprising CDR1 , CDR2 , and CDR3 sequences comprising the amino acid sequences of SEQ ID NOs: 13 , 14 , and 15 , respectively.64. The isolated antibody claim 63 , or antigen binding portion thereof claim 63 , of claim 63 , which binds to human CD73 with a Kof 0.1 nM to 10 nM claim 63 , as determined by Surface Plasmon Resonance (SPR).65. The isolated antibody claim 63 , or antigen binding portion thereof claim 63 , of claim 63 , which inhibits the activity of human CD73.66. The isolated antibody claim 63 , or antigen binding portion thereof claim 63 , of claim 63 , which mediates internalization of human CD73.67. The isolated antibody claim 63 , or antigen binding portion thereof claim 63 , of claim 63 , which has reduced effector function relative to a wild type IgG1 antibody.68. The isolated antibody claim 63 , or antigen binding portion thereof claim 63 , of claim 63 , which is a human IgG antibody.69. The ...

Fluid Purification Methods, Devices, and Systems

A fluid purification system has cells whose purifying capability can be regenerated. Some of the cells are arranged in series to reach a high level of purification. An automatic valve network is controlled to cycle the cells in a way that levels the loads on each, thereby maximizing the service interval for replacing expired cells, enabling all of the cells to be replaced at the same time after having each contributing approximately equally to the purification load, and operated such that at any one time, at least one cell is regenerated so as to enable continuous up-time. 1. A fluid purification system , comprising:a controller;a first multi-stage purifier and a second multi-stage purifier, each having multiple cells connectable in series for multi-stage purification of a fluid by an arrangement of controllable valves controlled by the controller; anda fluid circuit, controlled by the controller, configured to flow the fluid to be purified through the first multi-stage purifier, in a forward direction, while reverse flowing the fluid through the second multi-stage purifier while the fluid flows in reverse through a selected cell of the second multi-stage purifier, whereinthe controller is further configured to flow the fluid to be purified through the second multi-stage purifier, in a forward direction, while flowing in a reverse direction the fluid through the first multi-stage purifier while the fluid flows in reverse through a selected cell of the first multi-stage purifier.2. The system of claim 1 , wherein the flow in the forward direction flows through respective cells such that the cell that is most recently regenerated is last and the cell that was the least recently regenerated is first.3. The system of claim 1 , wherein the flow in the selected cell is the cell the least recently regenerated.4. The system of claim 1 , wherein the flowing of the fluid in the reverse direction is effective to regenerate the cells.5. The system of claim 1 , wherein the cells ...

Antibodies against cd73 and uses thereof

The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.

INFLATABLE IMBIBED POLYMER DEVICES

The present invention provides a stretchable material suitable for use in an inflatable medical device. The stretchable material has at least one reinforcing polymer layer with a top and bottom side forming a porous matrix which is imbibed with a sealing material to infiltrate and substantially seal spaces of the porous matrix and extend beyond the reinforcing polymer layer to form a surface coating. 1. A medical device comprising:an inflatable element including a composite membrane having a reinforcing layer and a polymer layer over the reinforcing layer, the reinforcing layer including a material having a porous microstructure, the polymer layer being formed by adding a polymeric material to the reinforcing layer such that the polymeric material is incorporated into the microstructure of the reinforcing layer and such that the polymeric material forms a coating on the reinforcing layer to define the polymer layer.2. The medical device of claim 1 , wherein the inflatable element is a balloon that is configured to inflate to a working diameter in response to introduction of a fluid into the balloon at a designated pressure.3. The balloon of claim 2 , wherein the fluid is a gas.4. The balloon of claim 2 , wherein the fluid is a liquid.5. The medical device of claim 1 , wherein the porous microstructure of the reinforcing layer includes a plurality of nodes and fibrils.6. The medical device of claim 1 , wherein the reinforcing layer includes ePTFE.7. The medical device of claim 1 , wherein the polymeric material is an elastomeric material.8. The stretchable material of wherein the sealing material is a polyether block amide.9. The stretchable material of claim 1 , wherein the polymeric material is a nylon.10. The medical device of claim 1 , wherein the polymeric material is imbibed into the microstructure of the reinforcing layer.11. The medical device of claim 1 , wherein the composite membrane comprises a tubular structure.12. The medical device of claim 11 , ...

Treatment Fluid Devices Methods and Systems

A conductivity measurement device includes first and second conductivity measurement flow channels positioned in a fluid circuit and fluidly linked for fluid flow between the first and second conductivity measurement flow channels. A controller having a current source connected to the first and second conductivity channels applies alternating voltages at frequencies that are different, each being respective to one of the first and second conductivity cells. 1. A conductivity measurement device , comprising:a first conductivity measurement flow channel;a second conductivity measurement flow channel, the first and second conductivity flow channels positioned in a fluid circuit and fluidly linked for fluid flow between the first and second conductivity measurement flow channels; anda controller having a current source connected to the first and second conductivity measurement flow channels, the controller being configured to apply alternating voltages at frequencies that are different, each frequency being respective to one of the first and second conductivity measurement flow channels.2. The device of claim 1 , wherein the controller is configured to measure voltage drops across respective channels of the first and second conductivity measurement flow channels.3. The device of claim 1 , wherein the respective frequency applied to the first conductivity measurement flow channel is between 1.2 and 5 times the respective frequency applied to the second conductivity measurement flow channel.4. The device of claim 1 , wherein the respective frequency applied to the first conductivity measurement flow channel is selected to prevent interference in measurement of voltage drop with the frequency applied to the second conductivity measurement flow channel.5. The device of claim 1 , whereinthe frequency applied to the first conductivity measurement flow channel is substantially greater than the frequency applied to the second conductivity measurement flow channel,the controller ...

CONDUCTIVE BROAD GOOD PROVIDING LIGHTNING STRIKE PROTECTION

A broad good, comprising a plurality of fibers looped randomly throughout the broad good, a binder material binding the plurality of fibers together, the plurality of bound fibers forming a dimensionally stable nonwoven veil, a first metal coating covering a surface of the plurality of bound fibers of the veil, and a second metal coating covering the surface of the first metal coating, wherein the first and second metal coatings form a highly conductive metal screen that follows the shape of the dimensionally stable nonwoven veil. 1. A conductive broad good , useful in the construction of an aircraft and in protecting the aircraft from a lightning strike , comprising:a plurality of carbon fibers randomly-oriented throughout the conductive broad good;a binder material binding the plurality of carbon fibers together, the plurality of bound fibers a dimensionally-stable nonwoven veil;{'sup': '2', 'a first metal coating covering a surface of the plurality of bound fibers and the binder material of the dimensionally-stable nonwoven veil, the first metal coating comprising copper and having a basis weight of about 10-50 g/m; and'}{'sup': '2', 'a second metal coating covering the surface of the first metal coating, the second metal coating comprising nickel and having a basis weight of about 5-20 g/m,'}{'sup': '2', 'wherein the first and second metal coatings form a highly-conductive metal screen that follows the shape of the dimensionally-stable nonwoven veil, and the conductive broad good has a basis weight of less than 60 g/mand a sheet resistance of less than 0.015 ohms per square (Ω/□).'}2. The conductive broad good of claim 1 , wherein the binder is a material selected from the group consisting of an acid-resistant binder material claim 1 , a base-resistant binder material claim 1 , and a material that is both acid-resistant and base-resistant.3. (canceled)4. (canceled)5. (canceled)6. The conductive broad good of claim 1 , wherein the first metal coating completely ...

SYSTEM AND METHOD FOR BLINDZONE OBJECT DETECTION

Various embodiments are described herein for a system and method for blindzone obstacle detection for a host vehicle. The system comprises a sensor array configured to generate measurement data for a blindzone of the host vehicle; a blindzone object detector having at least two detectors that are coupled to the sensor array to process the measurement data and generate outputs which are then combined to form a final detection value that is used to detect an object in the blindzone of the host vehicle. An indicator can also be coupled to the blindzone object detector to generate an indication of object detection in the blindzone. 1. A system for blindzone obstacle detection for a host vehicle , wherein the system comprises:a sensor array configured to generate measurement data for a blindzone of the host vehicle;a blindzone object detector comprising at least two detectors, the blindzone object detector being coupled to the sensor array to receive the measurement data, to process the measurement data using the at least two detectors and to combine outputs from the at least two detectors to form a final detection value used to detect an object in the blindzone of the host vehicle; andan indicator coupled to the blindzone object detector and being configured to generate an indication of object detection in the blindzone.2. The system of claim 1 , wherein the system further comprises an alarm coupled to one of the detector and the indicator claim 1 , the alarm being configured to generate an alarm signal when the detector detects the object in the blindzone.3. The system of claim 2 , wherein the alarm is configured to generate the alarm signal when the host vehicle is travelling at greater than a minimum speed.4. The system of claim 1 , wherein the system comprises an early warning alarm that is activated before a detected object enters the blindzone and the early warning alarm has a property that is changed when the detected object enters the blindzone.5. The system of ...

VIDEO RECORDER

Methods and apparatuses are disclosed for recording video data of an event. The apparatuses include a processor communicating with memory. The memory stores video data of the event captured by a camera, and the video data includes a series of picture frames of the event. A loop buffer also stores video data of the event captured by the camera. A rule-based engine stored in the memory uses a set of rules to store the contents of the loop buffer in the memory. The apparatus utilizes the loop buffer to provide video data prior to occurrence of the event. 1. (canceled)2. A system , comprising:a processor;a buffer in communication with the processor;a camera configured to capture video data associated with a vehicle;an accelerometer configured to collect accelerometer data; storing the video data in the buffer; and', 'in response to a triggering event, transferring the stored video data from the buffer to a second memory in the vehicle, wherein the triggering event is an occurrence of the accelerometer data exceeding a threshold and indicating one or both of (a) full jounce or rebound of a suspension component or (b) excessive yaw, pitch, or roll movement of the vehicle; and, 'a first memory having program instructions stored therein that are executable by the processor to cause the system to perform operations includinga wireless interface capable of transferring the video data from at least one of the camera, the buffer, or the second memory to a portable device.3. The system of claim 2 , further comprising:a microphone configured to capture audio data; storing the audio data in the buffer; and', 'in response to the triggering event, transferring the stored audio from the buffer to a remote device via the wireless interface., 'wherein the operations further include4. The system of claim 2 , wherein the camera is a first camera oriented to view outside the vehicle; and 'a second camera oriented to view inside the vehicle, wherein the stored video data includes video ...

Torque overlay steering apparatus

A steering apparatus for assisting rotation of a steering shaft in a steering system. The apparatus includes a motor having a drive shaft that rotates about a drive shaft axis and an output shaft that rotates about an output shaft axis. The output shaft axis extends parallel to the drive shaft axis. The output shaft is connected for rotation with the steering shaft. A gear train drivingly connects the motor to the output shaft. The gear train includes a worm screw and a worm wheel.

DENTAL CLEANING APPARATUS

A dental cleaning apparatus (DCA) includes an elongated member having a brush portion and a handle portion. The DCA includes multiple brushes with different respective geometries situated equiangularly about the brush portion. The brushes may include convex, concave and flat geometries with each brush being designated for cleaning a different respective tooth surface type. For each of the convex, concave and flat bushes, the DCA includes a respective tactile feel region exhibiting the same geometry as the brush type to aid the user in orienting the DCA in the mouth for tooth cleaning purposes. 1. A dental cleaning apparatus , comprising:an elongated member including a brush portion and a handle portion respectively situated at opposed ends of the elongated member; anda plurality of bristle arrays situated approximately equiangularly spaced about the brush portion of the elongated member, each bristle array of the plurality of bristle arrays exhibiting a different bristle array geometry, each bristle array geometry being shaped to brush a different type of tooth surface.2. The dental cleaning apparatus of claim 1 , wherein the plurality of bristle arrays includes a first bristle array exhibiting a concave geometry to brush a first type surface of a tooth.3. The dental cleaning apparatus of claim 2 , wherein the plurality of bristle arrays includes a second bristle array exhibiting a convex geometry to brush a second type surface of a tooth.4. The dental cleaning apparatus of claim 3 , wherein the plurality of bristle arrays includes a third bristle array exhibiting a substantially flat geometry to brush a third type surface of a tooth.5. The dental cleaning apparatus of claim 1 , wherein the handle portion includes a plurality of tactile feel regions claim 1 , each tactile feel region exhibiting a different tactile feel corresponding to a respective bristle array.6. The dental cleaning apparatus of claim 5 , wherein each tactile feel region is aligned with a ...

Parameter Monitoring in Medical Treatment Systems

A blood treatment system with pressure sensors may be configured to control blood flow to and from the patient and use readings of the pressure sensors to determine a change in a pressure drop across a flow restriction in the blood circuit to estimate a condition of the machine or the patient, or outputting data responsive to the estimation. Further embodiments employ measurement of pressure drop to detect abnormal viscosity or viscosity variations in order to detect possible infection. 1. A blood treatment system , comprising:a machine comprising one or more pumps;a blood circuit in engagement with the one or more pumps and having an inlet line and an outlet line for conveying blood to and from a patient, respectively;at least two pressure sensors in at least one of the inlet line or the outlet line; anda controller configured to control the one or more pumps to convey blood to and from the patient, the controller further configured to use readings of the at least two pressure sensors to determine a change over time in a pressure drop across a flow restriction in the blood circuit and perform a function responsive to the change in the pressure drop, the function comprising at least one of: generating a notification, adjusting a blood flow rate in the blood circuit, outputting an estimation of a condition of the machine or the patient, or outputting data responsive to said estimation.2. The system of claim 1 , wherein the controller is configured to sample the pressure drop at multiple times over a period of time comprising a single treatment or multiple treatments and store data responsive thereto claim 1 , wherein the change in the pressure drop is determined based on a trend over time of the stored data.3. The system of claim 2 , wherein the controller claim 2 , responsively to said trend claim 2 , generates a user notification claim 2 , caution claim 2 , or alarm claim 2 , indicating that the trend is exceeding a limit.4. The system of claim 2 , wherein the ...

PASSIVE SAFETY INTRAOSSEOUS DEVICE

A portable and passive safety intraosseous device to allow for direct introduction of medications, etc., within the intermedullary space of a subject patient's bone or, if needed, the removal of certain substances from such a subject patient's bone. Such a device permits direct drilling and placement of a cannula within the subject bone with access external to the subject patient's skin, permitting, as well, connection of a tube for such introduction/removal purposes. The ability to provide a passive safety unit allows for facilitated utilization in, for instance, emergency situations with the entire device provided for utilization thereof. The device includes a drilling component with a permanently attached stylet and a removable cannula, a power supply for a single drilling operation, a mechanism to draw the stylet back into the drill component after use and disengagement from the cannula, and an automatic closure that activates with the separation of the cannula. 1. A single-use , disposable intraosseous drill device , said device comprising a foldable combination of a separable barrel and handle with a connector allowing rotation thereof in relation to one another , said barrel having an open end and a closed end and comprising a single-structure motor and stylet assembly therein that is movable through utilization of a manual external implement within said housing from a location at or near said closed end towards said open end , wherein said motor/stylet assembly further including a detachable cannula attached thereto having a bore through which said stylet extends into and externally from , wherein said motor/stylet assembly includes a retracting component to automatically return said motor/stylet assembly back towards said closed end of said barrel upon detachment from said cannula , and wherein said handle comprises a power source to generate sufficient power for operation of said drill through said motor.2. The device of wherein said handle exhibits a flat ...

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. 1. A system for regulating balanced flow of fluids , comprising:a fluid circuit with first and second fluid channels connectable to a fluid handling device, each with at least one respective pump for each of said first and second fluid channels, a controller connected to the respective pumps to control a rate of pumping of one or more of said respective pumps, the controller being connected to one or more valves to permit it to establish flows in the first and second channels;a ratio of flow rates of entering and leaving flows to and from the fluid handling device is controlled by said controller to effect a predefined net transfer of fluid to or from the fluid handling device responsively to calibration data accessible to said controller;the controller, at selected times, temporarily establishing one or more calibration flow paths in said fluid circuit, the calibration flow paths communicating respectively with ones of said first and second fluid channels to cause flow through a flow measurement component that generates a signal indicating a flow rate or relative flow rate generated by said respective pumps;the controller sampling the signal and in response to resulting samples, the controller adjusting said calibration data;the controller, using the adjusted calibration data stored in said controller to adjust the one or more of said respective pumps in order to effect said predefined net transfer of fluid to or from the fluid handling device;the selected times being determined by the controller responsively to detection ...

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. 1. A medical treatment method , comprising:at treatment times, using peristaltic pumps, flowing medicament into and out of inflow and outflow channels connectable to a patient or treatment device;at calibration times, over a calibration interval of less than a minute, flowing medicament directly between the inflow and outflow channels such that pulsations generated by the peristaltic pumps cause pressure in a bridge channel between the inflow and outflow channels to fluctuate due to a superposition of a suction side pulsation and a pressure side pulsation of respective ones of said peristaltic pumps; andusing an adjustable flow restrictor, selecting a suction head of at least one of the respective ones of the peristaltic pumps so as to change a pulsation frequency thereof so that it differs from that of the other of the ones of the peristaltic pumps by a predetermined amount.2. The method of claim 1 , wherein the predetermined amount is such that a ratio of an inverse of a difference between pulsation frequencies of the ones of the peristaltic pumps is multiple times the calibration interval.3. The method of claim 1 , wherein the predetermined amount is such that a ratio of an inverse of a difference between pulsation frequencies of the ones of the peristaltic pumps is three times the calibration interval.4. The method of claim 1 , wherein the predetermined amount is such that a ratio of an inverse of a difference between pulsation frequencies of the ones of the peristaltic pumps is five times the calibration interval.5. The ...

HEATING BLANKET AND METHOD FOR USE

A heating blanket (), useful for debulking and/or curing composite materials, comprising at least one heating element comprising a carbon nanotube (CNT) structured layer defining an electrically conductive pathway having a first end and a second end and a first electrical terminal () electrically coupled to the first end and a second electrical terminal () electrically coupled to the second end, and an elastomeric outer covering, encasing the at least one heating element, wherein the at least one heating element is responsive to an electromotive force applied across the first and the second electrical terminals to produce heat. 1. A heating blanket , useful for debulking and/or curing composite materials , comprising:at least one heating element comprising:a carbon nanotube (CNT) structured layer defining an electrically conductive pathway having a first end and a second end; and,a first electrical terminal electrically coupled to the first end and a second electrical terminal electrically coupled to the second end; and,an elastomeric outer covering, encasing the at least one heating element;wherein the at least one heating element is responsive to an electromotive force applied across the first and the second electrical terminals to produce heat.2. The heating blanket of claim 1 , wherein the elastomeric outer covering is cured so that the heating blanket forms a resilient three-dimensional shape that follows the shape of at least one of a caul tool associated with a part or a part that is to be produced.3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. The heating blanket of claim 3 , wherein the thickness of the at least one heating element is between 0.25 millimeters (mm) and 5 mm.8. (canceled)9. (canceled)10. (canceled)11. (canceled)12. The heating blanket of claim 1 , the structured CNT layer comprises a carbon nanotube (CNT)-polymer film structure including single wall carbon nanotubes (SWCNTs) dispersed in a silicon structure claim 1 , wherein the mass ...

SYSTEM FOR PROVIDING AN ISOLATED TESTING MODEL FOR DISASTER RECOVERY CAPABILITES

A system for providing an isolated testing model for testing the disaster recovery capabilities of a streamlined backup network backing up a primary network. The primary network provides one or more users access to critical data and critical services. The system is configured to be switched between a production mode and a test mode. When the system is in the test mode, the primary network and the streamlined backup network form a live production environment and the streamlined backup network provides the one or more users access to the critical data and the critical services in the event the primary network is unable to do so. When the system is in the test mode, the streamlined backup network is removed from the live production environment by physically and logically isolating the streamlined backup network from the primary network. 1. A system for providing an isolated testing configuration for disaster recovery capabilities , comprising:a primary network comprising a first data server and a first service server that provide one or more users access to critical data and critical services;a streamlined backup network comprising a second data server and a second service server that also provide the one or more users access to the critical data and the critical services; andan isolation appliance connecting the primary network and the streamlined backup network; a production mode wherein the primary network and the streamlined backup network form a live production environment wherein the streamlined backup network provides the one or more users backup access to the critical data and the critical services in the event the primary network is unable provide access to the critical data and the critical services, and', 'a test mode wherein the streamlined backup network is removed from the live production environment by logically isolating the streamlined backup network from the primary network such that backup access to the critical data and the critical services on the ...

Antibodies against cd73

The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.

Computer System for Generating and Displaying Interactive User Interfaces

A computer system generates interactive user interfaces. The system is configured to receive first data input via a user interface, access stored data including guideline data based on the received first data, and generate a modified user interface based on the accessed stored data. The first data, and second data received via the modified user interface, are processed and employed for adjusting workflows. 1. A computer system for generating and displaying one or more interactive user interfaces and processing input data , comprising:one or more data storage devices storing data indicative of compliance guideline data for a plurality of jurisdictions and policy data for a plurality of auto insurance policies;one or more computer processors; and output an auto insurance data collection user interface including at least one data field for entry of information about an auto insurance claim for display on a display device;', 'receive first data associated with the auto insurance claim via the user interface;', 'retrieve compliance guideline data applicable to the claim from the one or more data storage devices, based on the first data;', 'modify the user interface by at least one of adding additional data fields or removing data fields based on the retrieved compliance guideline data and the first data;', 'retrieve policy data applicable to the claim based on the first data;', 'populate one or more data fields included in the user interface with the retrieved policy data;', 'receive second data via the modified user interface;', 'output the first data and the second data, and', 'adjust an auto insurance claim workflow based on the output data., 'a memory storing computer-readable instructions, which instructions, when executed by the one or more computer processors, cause the one or more computer processors to2. The computer system of claim 1 , wherein the instructions causing the one or more computer processors to modify the user interface comprises adding questions ...

SUSTAINED RELEASE COMPOSITIONS OF 4-AMINOPYRIDINE

The present invention generally relates to sustained release 4-aminopyridine tablets, which include a core and a coating. The sustained release tablets of the invention are generally suitable for once daily oral administration for the treatment of neurological disorders. 1. A sustained release tablet comprising:(a) a compressed core, said compressed core comprising 4-aminopyridine, a polyethylene oxide with a molecular weight between about 1,000,000 and 10,000,000, and a mixture comprising polyvinyl acetate and polyvinyl pyrrolidone; and(b) an amount of an ethylcellulose coat surrounding said compressed core, said amount of the ethylcellulose coat being in the range of about 5% w/w to about 10% w/w of the compressed core.2. The sustained release tablet of claim 1 , wherein said mixture further comprises one or more pharmaceutically acceptable excipients.3. The sustained release tablet of claim 1 , wherein said mixture comprises 70-90% polyvinyl acetate and 15-20% polyvinyl pyrrolidone.4. The sustained release tablet of any of - claim 1 , wherein said mixture further comprises a surfactant.5. The sustained release tablet of claim 4 , wherein said mixture further comprises silica.6. The sustained release tablet of any of - claim 4 , wherein said mixture consists of about 80% polyvinyl acetate claim 4 , about 19% polyvinyl pyrrolidone claim 4 , about 0.8% sodium lauryl sulfate claim 4 , and about 0.2% silica.7. The sustained release tablet of any of - claim 4 , wherein the compressed core further comprises a filler and a lubricant.8. The sustained release tablet of claim 7 , wherein the filler is dibasic calcium phosphate dihydrate claim 7 , and the lubricant is magnesium stearate.9. The sustained release tablet of any of - claim 7 , wherein the polyethylene oxide has a molecular weight between 4 claim 7 ,000 claim 7 ,000 and 8 claim 7 ,000 claim 7 ,000.10. The sustained release tablet of any of - claim 7 , wherein the polyethylene oxide has a molecular weight of 7 ...

SYSTEM FOR PROVIDING AN ISOLATED TESTING MODEL FOR DISASTER RECOVERY CAPABILITIES

A system for providing an isolated testing model for testing the disaster recovery capabilities of a streamlined backup network backing up a primary network. The primary network provides one or more users access to critical data and critical services. The system is configured to be switched between a production mode and a test mode. When the system is in the test mode, the primary network and the streamlined backup network form a live production environment and the streamlined backup network provides the one or more users access to the critical data and the critical services in the event the primary network is unable to do so. When the system is in the test mode, the streamlined backup network is removed from the live production environment by physically and logically isolating the streamlined backup network from the primary network. 1. A system for providing an isolated testing configuration for disaster recovery capabilities , comprising:a primary network comprising at least one first server that provides one or more users access to data and services;a streamlined backup network comprising at least one second server that also provides the one or more users access to the data and the services; andan isolation appliance comprising one or more switches establishing an external network connection between the primary network and the streamlined backup network; a production mode wherein the primary network and the streamlined backup network form a live production environment wherein the streamlined backup network provides the one or more users backup access to the data and the services in the event the primary network is unable provide access to the data and the services, and', 'a test mode wherein the streamlined backup network is removed from the live production environment by isolating the streamlined backup network from the primary network such that backup access to the data and the services on the streamlined backup network is tested without inhibiting the ...

VIDEO RECORDER

Methods and apparatuses are disclosed for recording video data of an event. The apparatuses include a processor communicating with memory. The memory stores video data of the event captured by a camera, and the video data includes a series of picture frames of the event. A loop buffer also stores video data of the event captured by the camera. A rule-based engine stored in the memory uses a set of rules to store the contents of the loop buffer in the memory. The apparatus utilizes the loop buffer to provide video data prior to occurrence of the event. 1. (canceled)2. A system , comprising:a processor;a buffer in communication with the processor;a camera configured to capture video data associated with a vehicle; storing the video data in the buffer;', transferring the stored video data from the buffer to a storage in the vehicle; and', 'tagging the stored video with metadata indicative of the triggering event; and, 'in response to a triggering event], 'memory having program instructions stored therein that are executable by the processor to cause the system to perform operations includingan interface capable of transferring the video data from at least one of the camera, the buffer, or the storage to a portable device.3. The system of claim 2 , wherein the operations further include:identifying the triggering event by evaluating a set of rules; andwherein the metadata includes a description of a particular one of the set of rules that caused the video data to be transferred from the buffer to the storage.4. The system of claim 2 , wherein the metadata includes a description of the video data.5. The system of claim 2 , wherein the metadata identifies an attempted access event associated with the vehicle.6. The system of claim 2 , wherein the operations further include:receiving vehicular data from one or more sensors within in the vehicle.7. The system of claim 6 , wherein the vehicular data includes accelerometer data from an accelerometer installed in the vehicle.8 ...

APPARATUS AND METHOD FOR TURNING STEERABLE VEHICLE WHEELS

A method for turning steerable wheels of a vehicle includes supplying fluid under pressure to a hydraulic power steering motor with a pump driven by an engine of the vehicle to turn the steerable wheels during operation of the engine. It is determined if the engine of the vehicle is shut down. An electric motor applies power assist to turn the steerable wheels when the engine is shut down. An apparatus for turning steerable vehicle wheels includes a hydraulic power steering motor assembly connected with the steerable vehicle wheels. A pump connected with the power steering motor assembly is driven by an engine of the vehicle to supply fluid under pressure to the power steering motor assembly during operation of the engine. An electric motor connected with the steerable vehicle wheels applies power assist to turn the steerable vehicle wheels. A controller operates the electric motor to apply the power assist when the engine is shut down. 1. A method for turning steerable wheels of a vehicle , the method comprising the steps of:supplying fluid under pressure to a hydraulic power steering motor with a pump driven by an engine of the vehicle to turn the steerable wheels during operation of the engine;determining if the engine of the vehicle is shut down; andapplying power assist with an electric motor to turn the steerable wheels when the engine is shut down.2. The method as set forth in wherein the step of applying power assist with the electric motor includes applying a torque to a hand wheel of the vehicle with the electric motor.3. The method as set forth in wherein the step of applying power assist with the electric motor includes applying a torque to an input shaft of a directional control valve that directs fluid from the pump to the hydraulic power steering motor during operation of the engine.4. The method as set forth in further including determining if the vehicle is moving and applying the power assist with the electric motor when the engine is shut down and ...

METHOD OF MAKING A COMPOSITE MATERIAL INCLUDING A THERMOPLASTIC POLYMER, A PEST FOOD MATERIAL AND A PESTICIDE

Composite materials that are palatable to a wood-destroying pest species and also pesticidal to the pest species can be used in pest control devices and can be used as wood substitutes for structural components, which are resistant to destruction by wood-destroying pests. The composite materials include a thermoplastic polymer, a food material for the pest and a pesticide. The composite material is formed by mixing a thermoplastic polymer, wood fragments or other cellulosic materials and a quantity of pesticide, and thereafter creating a molten material within a mixer, compounder, extruder or the like. The molten material is extruded or molded to form the desired shape. 125-. (canceled)26. A method of making a solid composite bait that is palatable to termites , the method comprising:extruding a mixture of (i) a thermoplastic polymer, (ii) a cellulosic food material that is palatable to termites, and (iii) a pesticide that is toxic to termites to form a workpiece having a desired shape, andcooling the workpiece to a temperature to form the solid composite bait.27. The method of claim 26 , wherein the thermoplastic polymer has a melting point below 220° C.28. The method of claim 27 , wherein the thermoplastic polymer is selected from a group consisting of cellulose acetate claim 27 , cellulose acetate butyrate claim 27 , cellulose acetate propionate claim 27 , poly lactic acid and combinations thereof.29. The method of claim 26 , wherein the pesticide comprises a member selected from the group consisting of hexaflumuron claim 26 , noviflumuron claim 26 , chlorpyrifos claim 26 , spinosad claim 26 , imidacloprid claim 26 , fipronil claim 26 , lufenuron claim 26 , diflubenzuron claim 26 , flufenoxuron and hydramethylnon.30. The method of claim 26 , wherein the cellulosic food material is selected from the group consisting of wood fibers claim 26 , purified cellulose claim 26 , microcrystalline cellulose and modified polymeric cellulose.31. The method of claim 30 , ...

COMPOSITE MATERIAL INCLUDING A THERMOPLASTIC POLYMER, A PEST FOOD MATERIAL AND A PESTICIDE

Composite materials that are palatable to a wood-destroying pest species and also pesticidal to the pest species can be used in pest control devices and can be used as wood substitutes for structural components, which are resistant to destruction by wood-destroying pests. The composite materials include a thermoplastic polymer, a food material for the pest and a pesticide. The composite material is formed by mixing a thermoplastic polymer, wood fragments or other cellulosic materials and a quantity of pesticide, and thereafter creating a molten material within a mixer, compounder, extruder or the like. The molten material is extruded or molded to form the desired shape. 125-. (canceled)26. A composite material for use in pest control , the composite material comprising:a plastic structural matrix that comprises cellulose acetate butyrate (CAB);a cellulosic food material that is palatable to a pest; anda pesticide that is toxic to the pest.27. The composite material of wherein the CAB is selected from the group consisting of CAB having a degree of polymerization from about 50 units to about 400 units claim 26 , CAB having a degree of polymerization from about 100 units to about 300 units claim 26 , CAB having a degree of polymerization of about 160 units claim 26 , and a combination thereof.28. The composite material of wherein the CAB comprises (a) a mixture of CAB having from about 50 monomer units to about 75 monomer units and CAB having from about 150 to about 300 monomer units claim 26 , (b) a mixture of CAB having about 60 monomer units and CAB having about 300 monomer units claim 26 , or (c) a mixture of CAB having about 64 monomer units and CAB having about 160 monomer units.29. The composite material of wherein the CAB comprises a mixture of CAB having a molecular weight of about 16 claim 26 ,000 and CAB having a molecular weight of about 40 claim 26 ,000.30. The composite material of wherein the plastic structural matrix further comprises at least one ...

COMBINATION THERAPY WITH ANTI-CD73 ANTIBODIES

Provided are methods for clinical treatment of tumors (e.g., advanced solid tumors) using an anti-CD73 antibody in combination with an immuno-oncology agent, such as an anti-PD-1 antibody. 164-. (canceled)65. A method of treating cancer in a subject having a tumor that expresses CD73 , comprising administering to the subject a therapeutically effective amount of a CD73 antagonist and an immuno-oncology agent , wherein(a) the CD73 antagonist is administered at a dose of about 150 mg to about 1600 mg, and the immuno-oncology agent is administered at a dose of about 50 mg to about 500 mg, once per week, once every 2 weeks, once every 3 weeks, or once every 4 four weeks, or(b) the CD73 antagonist is administered at a dose of about 150 mg to about 1600 mg once per week and the immuno-oncology agent is administered at a dose of about 50 mg to about 500 mg once every 2 weeks, once every 3 weeks or once every 4 four weeks.66. The method of claim 65 , wherein(a) the CD73 antagonist is administered at a dose of about 600 mg once per week or once every 2 weeks, and(b) the immuno-oncology agent is administered at about 240 mg once every 2 weeks or at about 480 mg once every 4 weeks.67. The method of claim 65 , wherein the CD73 antagonist and the immuno-oncology agent are administered for 1 to 10 cycles claim 65 , wherein each cycle is a period of 28 days.68. The method of claim 65 , wherein the CD73 antagonist and the immuno-oncology agent are administered on the same day.69. The method of claim 65 , wherein the CD73 antagonist and immuno-oncology agent are formulated for intravenous administration.70. The method of claim 65 , wherein the CD73 antagonist and immuno-oncology agent are formulated separately.71. The method of claim 65 , wherein the CD73 antagonist and immuno-oncology agent are formulated together.72. The method of claim 65 , wherein the CD73 antagonist is administered prior to administration of the immuno-oncology agent.73. The method of claim 65 , wherein the ...

VIDEO RECORDER

Methods and apparatuses are disclosed for recording video data of an event. The apparatuses include a processor communicating with memory. The memory stores video data of the event captured by a camera, and the video data includes a series of picture frames of the event. A loop buffer also stores video data of the event captured by the camera. A rule-based engine stored in the memory uses a set of rules to store the contents of the loop buffer in the memory. The apparatus utilizes the loop buffer to provide video data prior to occurrence of the event. 1a processor communicating with memory, the memory for storing video data of an event captured by a camera, the video data comprising a series of picture frames;a loop buffer also storing video data of the event captured by the camera; anda set of rules stored in the memory, the set of rules determining when to transfer the contents of the loop buffer into the memory,wherein the video recorder utilizes the loop buffer to provide video data preceding the event.. A video recorder, comprising: This application is a continuation of co-pending U.S. application Ser. No. 10/674,770, filed on Sep. 30, 2003, and entitled “Video Recorder”, which is expressly incorporated herein by reference in its entirety.This patent application relates to the co-pending and commonly-assigned U.S. application Ser. No. 10/674,840 (docket BS030144), filed Sep. 30, 2003, and entitled “Video Recorder,” of which the “Brief Summary Of The Invention” section and the “Detailed Description of the Invention” section are incorporated herein by reference.This patent application also relates to the co-pending and commonly-assigned U.S. application Ser. No. 10/674,995 (docket BS030264), filed Sep. 30, 2003, and entitled “Video Recorder,” of which the “Brief Summary Of The Invention” section and the “Detailed Description of the Invention” section are incorporated herein by reference.A portion of the disclosure of this patent document and its figures contain ...

COMBINATION INTRAOSSEOUS DRILL AND FLASHLIGHT

A portable and passive safety intraosseous device to allow for direct introduction of medications, etc., within the intermedullary space of a subject patient's bone or, if needed, the removal of certain substances from such a subject patient's bone. Such a device permits direct drilling and placement of a cannula within the subject bone with access external to the subject patient's skin, permitting, as well, connection of a tube for such introduction/removal purposes. The ability to provide a passive safety unit allows for facilitated utilization in, for instance, emergency situations with the entire device provided for utilization thereof. The device includes a drilling component with a permanently attached stylet and a removable cannula, a power supply for a single drilling operation, a mechanism to draw the stylet back into the drill component after use and disengagement from the cannula, and an automatic closure that activates with the separation of the cannula. 1. An intraosseous drill device including a stylet and cannula combination for introduction within a target bone , a motor to provide drilling operation of said stylet and cannula combination , at least one light positioned on the surface of said device and exhibiting at least 10 candelas light power , and a power source for said motor and said at least one light.2. The device wherein more than one light is present on said device surface.3. The device of wherein said at least one light is disposed in the same general direction as said stylet and cannula combination as they are drilling within said target bone.4. The device of wherein said at least one light remains activated subsequent to a drilling operation.5. A method of introducing substances into and/or removing substances from a target intramedullary space of a bone utilizing the device of claim 1 , said method comprising the steps of:a) providing said device with said at least one light activated;b) determining the properly located bone portion ...

INFLATABLE IMBIBED POLYMER DEVICES

The present invention provides a stretchable material suitable for use in an inflatable medical device. The stretchable material has at least one reinforcing polymer layer with a top and bottom side forming a porous matrix which is imbibed with a sealing material to infiltrate and substantially seal spaces of the porous matrix and extend beyond the reinforcing polymer layer to form a surface coating. 132-. (canceled)33. A balloon comprising a porous membrane configured to inflate to a working diameter in response to introduction of a fluid at a first pressure , wherein the fluid begins to perfuse through the balloon at a second pressure , the second pressure being at least equal to or greater than the first pressure.34. The balloon of claim 33 , further comprising a surface coating disposed on the porous membrane having a thickness sufficient for controlled porosity when strained due to inflation.35. The balloon of claim 33 , wherein the fluid is a gas.36. The balloon of claim 33 , wherein the fluid is a liquid.37. The balloon of claim 33 , wherein the fluid comprises a therapeutic liquid agent.38. The balloon of claim 33 , wherein the fluid comprises water.39. The balloon of claim 33 , wherein the fluid inflates the balloon.40. The balloon of claim 33 , wherein the porous membrane is tubular.41. The balloon of claim 33 , wherein the porous membrane comprises a tubular structure.42. The balloon of claim 41 , wherein the tubular structure comprises sealed ends.43. The balloon of claim 33 , wherein the second pressure is at least 10 atm.44. A balloon comprising a porous membrane comprising a porous microstructure configured to inflate to a working diameter in response to introduction of a fluid at a first pressure claim 33 , wherein the fluid begins to substantially perfuse through the balloon at a second pressure claim 33 , the second pressure being at least equal to or greater than the first pressure claim 33 , wherein the second pressure is at least 10 atm.45. The ...

SYSTEM FOR PROVIDING AN ISOLATED TESTING MODEL FOR DISASTER RECOVERY CAPABILITES

A system for providing an isolated testing model for testing the disaster recovery capabilities of a streamlined backup network backing up a primary network. The primary network provides one or more users access to critical data and critical services. The system is configured to be switched between a production mode and a test mode. When the system is in the test mode, the primary network and the streamlined backup network form a live production environment and the streamlined backup network provides the one or more users access to the critical data and the critical services in the event the primary network is unable to do so. When the system is in the test mode, the streamlined backup network is removed from the live production environment by physically and logically isolating the streamlined backup network from the primary network. 1. A system for providing an isolated testing configuration for disaster recovery capabilities , comprising:a primary network comprising a first data server and a first service server that provide one or more users access to critical data and critical services; anda streamlined backup network comprising a second data server and a second service server that also provide the one or more users access to the critical data and the critical services; a production mode wherein the primary network and the streamlined backup network form a live production environment wherein the streamlined backup network provides the one or more users backup access to the critical data and the critical services in the event the primary network is unable provide access to the critical data and the critical services, and', 'a test mode wherein the streamlined backup network is removed from the live production environment by logically isolating the streamlined backup network from the primary network such that the ability of the streamlined backup network to provide the one or more users backup access to the critical data and the critical services can be tested ...

VIDEO RECORDER

Methods and apparatuses are disclosed for recording video data of an event. The apparatuses include a processor communicating with memory. The memory stores video data of the event captured by a camera, and the video data includes a series of picture frames of the event. A loop buffer also stores video data of the event captured by the camera. A rule-based engine stored in the memory uses a set of rules to store the contents of the loop buffer in the memory. The apparatus utilizes the loop buffer to provide video data prior to occurrence of the event. 1. (canceled)2. A system , comprising:a processor;a buffer in communication with the processor;a camera configured to capture video data;a wireless interface; and receiving vehicle data from an ignition sensor of a vehicle;', 'in response to the received vehicle data, storing the video data in the buffer; and', 'in response to a triggering event, transferring the stored video from the buffer to a remote device via the wireless interface., 'memory having program instructions stored therein that are executable by the processor to cause the system to perform operations including3. The system of claim 2 , further comprising a microphone configured to capture audio data claim 2 , wherein the operations further include:in response to the received vehicle data, storing the audio data in the buffer; andin response to the triggering event, transferring the stored audio from the buffer to the remote device via the wireless interface.4. The system of claim 2 , wherein the operations further include claim 2 , in response to the triggering event claim 2 , transferring the stored video from the buffer to a different memory device in the vehicle.5. The system of claim 4 , wherein the different memory device is at least one of a memory subsystem or a flash memory.6. A system claim 4 , comprising:a processor; and receiving vehicle data from an ignition sensor of a vehicle;', 'receiving video data from a camera; and', 'in response to ...

CANNULA WITH RECESSED HUB STRUCTURE

A portable and passive safety intraosseous device to allow for direct introduction of medications, etc., within the intermedullary space of a subject patient's bone or, if needed, the removal of certain substances from such a subject patient's bone. Such a device permits direct drilling and placement of a cannula within the subject bone with access external to the subject patient's skin, permitting, as well, connection of a tube for such introduction/removal purposes. The ability to provide a passive safety unit allows for facilitated utilization in, for instance, emergency situations with the entire device provided for utilization thereof. The device includes a drilling component with a permanently attached stylet and a removable cannula, a power supply for a single drilling operation, a mechanism to draw the stylet back into the drill component after use and disengagement from the cannula, and an automatic closure that activates with the separation of the cannula. 1. A cannula implement for utilization with a complementarily configured stylet within an intraosseous drill device for introduction of substances within the intermedullary space of a patient's bone, wherein said cannula implement comprises a needle portion on one end and a hub portion on the opposite end, wherein said hub portion includes a recessed opening leading to a bore for substance introduction through said needle portion wherein said recessed opening further includes suitable configured attachment implements therein for connection and disengagement between said cannula and said stylet on demand as well as between a transfer line for delivery of said substances on demand, wherein no extensions from said hub are present for connections between said stylet or said transfer line. This application is a continuation-in-part of pending U.S. patent application Ser. No. 16/125,767, filed on Sep. 10, 2018, which claims the benefit of expired U.S. Provisional Patent Application Nos. 62/556,397, filed on ...

COMPOSITE MATERIAL INCLUDING A THERMOPLASTIC POLYMER, A PEST FOOD MATERIAL, AND A PESTICIDE

Composite materials that are palatable to a wood-destroying pest species and also pesticidal to the pest species can be used in pest control devices and can be used as wood substitutes for structural components, which are resistant to destruction by wood-destroying pests. The composite materials include a thermoplastic polymer, a food material for the pest and a pesticide. The composite material is formed by mixing a thermoplastic polymer, wood fragments or other cellulosic materials and a quantity of pesticide, and thereafter creating a molten material within a mixer, compounder, extruder or the like. The molten material is extruded or molded to form the desired shape. 125.-. (canceled)26. A method of delivering a pesticide to a pest , said method comprising the step of providing a pest control device to the pest ,wherein the pest control device comprises a composite material comprising i) a plastic structural matrix that comprises cellulose acetate butyrate (CAB), ii) a cellulosic food material that is palatable to the pest, and iii) a pesticide that is toxic to the pest, andwherein consumption of the composite material by the pest delivers the pesticide to the pest.27. The method of claim 26 , wherein the method further comprises the step of installing the pest control device in an area to be protected from the pest.28. The method of claim 26 , wherein the pest control device further comprises a pest sensor and a communication circuitry coupled to the pest sensor.29. The method of claim 28 , wherein the pest sensor includes a pest sensing circuit.30. The method of claim 29 , wherein the pest sensing circuit includes an electrically conductive loop arranged to be altered during consumption or displacement of the cellulosic food material.31. The method of claim 26 , wherein the electrically conductive loop is coupled to the communication circuitry to provide a two-state signal.32. The method of claim 31 , wherein the two-state signal comprises a first state of the ...

AUTOMATICALLY DETACHABLE COLLAR PENDANT SYSTEM

The automatically detachable collar pendant system is structured so that when the system receives a signal, one end of the collar is released from the rest of the collar body, thereby unfastening the collar and allowing the collar to fall off of a target animal. The “signal” may comprise a magnetic or induction heat signal. In the preferred embodiment, the signal is received (and the collar is unfastened) when the target animal feeds at a specially-equipped bait station. 1. An automatically detachable collar pendant system for a target animal , the system comprising:a flexible collar having first and second ends;a front pendant segment attached to the first end of the collar, and,an intermediate pendant segment attached to the second end of the collar; and,a pendant detachment assembly connecting the front and intermediate segments so that the front segment and intermediate segments are fastened together;wherein the pendant system is structured so that when the pendant detachment assembly receives a signal, the front segment unfastens from the intermediate segment and the pendant system is able to fall off of the target animal.2. The system of wherein the system further comprises a rear segment claim 1 , the system being structured so that the intermediate segment is sandwiched between the front and rear segments.3. The system of wherein the pendant detachment assembly further comprises a connecting member that extends through the front segment and at least into the intermediate segment.4. The system of wherein the pendant detachment assembly further comprises a connecting member that extends through the front segment and through the intermediate segment and at least into the rear segment.5. The system of wherein the connecting member comprises a pin.6. The system of wherein the pendant detachment assembly further comprises a spring and the signal comprises a magnetic signal claim 1 , so that when the pendant attachment assembly receives the magnetic signal claim 1 ...

AUTOMATICALLY-ATTACHING COLLAR CLASPS

The automatically attaching collar clasps are installed in an animal bait station. The bait station has an inlet so that when an animal is positioned in the inlet, a male clasp on one side of the inlet automatically converges with a female clasp on the opposite side to the inlet to create a ratcheting connection and thereby secures a collar around the neck of the targeted animal. 1. An automatically-attaching collar system for a target animal , the system comprising:a flexible collar having first and second ends;a male clasp comprising an elongated projection, the male clasp being connected to the first end of the collar;a female clasp comprising a receiving aperture, the female clasp being connected to the second end of the flexible collar; and,a bait station inlet, the male clasp being positioned on one side of the inlet, and a female clasp being positioned on the other side of the inlet;wherein, as the target animal enters the inlet, the male clasp and the female clasps converge so that the elongated projection of the male clasp enters the female receiving aperture, thereby fastening the collar around the target animal's neck.2. The system of wherein the elongated projection comprises a harpoon.3. The system of wherein the collar comprises a pesticide-saturated plastic collar.4. The system of wherein the collar comprises an RFID tag.5. The system of wherein the elongated projection has a semi-rigid structure.6. The system of wherein the receiving aperture has a conical shape so that the elongated projection is directed into a retention channel within the female clasp.7. The system of wherein the female clasp comprises a pawl that connects with the harpoon to create a ratcheting connection.8. The system of wherein the pawl is comprised of metal and is positioned inside a retention channel in the female clasp.9. The system of wherein at least one sensor is positioned in the bait station inlet claim 1 , the sensor detecting a position of the target animal in the ...

SUSTAINED RELEASE COMPOSITIONS OF 4-AMINOPYRIDINE

The present invention generally relates to sustained release 4-aminopyridine tablets, which include a core and a coating. The sustained release tablets of the invention are generally suitable for once daily oral administration for the treatment of neurological disorders. 1. A sustained release tablet comprising:(a) a compressed core, said compressed core comprising 4-aminopyridine, a polyethylene oxide with a molecular weight between about 1,000,000 and 10,000,000, and a mixture comprising polyvinyl acetate and polyvinyl pyrrolidone; and(b) an amount of an ethylcellulose coat surrounding said compressed core, said amount of the ethylcellulose coat being in the range of about 5% w/w to about 10% w/w of the compressed core.2. The sustained release tablet of claim 1 , wherein said mixture further comprises one or more pharmaceutically acceptable excipients.3. The sustained release tablet of claim 1 , wherein said mixture comprises 70-90% polyvinyl acetate and 15-20% polyvinyl pyrrolidone.4. The sustained release tablet of any of - claim 1 , wherein said mixture further comprises a surfactant.5. The sustained release tablet of claim 4 , wherein said mixture further comprises silica.6. The sustained release tablet of any of - claim 4 , wherein said mixture consists of about 80% polyvinyl acetate claim 4 , about 19% polyvinyl pyrrolidone claim 4 , about 0.8% sodium lauryl sulfate claim 4 , and about 0.2% silica.7. The sustained release tablet of any of - claim 4 , wherein the compressed core further comprises a filler and a lubricant.8. The sustained release tablet of claim 7 , wherein the filler is dibasic calcium phosphate dihydrate claim 7 , and the lubricant is magnesium stearate.9. The sustained release tablet of any of - claim 7 , wherein the polyethylene oxide has a molecular weight between 4 claim 7 ,000 claim 7 ,000 and 8 claim 7 ,000 claim 7 ,000.10. The sustained release tablet of any of - claim 7 , wherein the polyethylene oxide has a molecular weight of 7 ...

Fluid Conveyance Safety Devices, Methods, and Systems

A vascular access device may include a blood circuit having an arterial blood line and a venous blood line. The venous blood line is connected to a first access needle and the arterial blood line is connected to a second access needle. The venous blood line is connected to an access component affixed to the second access needle and configured such that when the second access needle is used to infuse blood into a patient, the access component is positioned to withdraw blood and convey it into the venous line. The withdrawn blood may also be conveyed to an air detector to detect withdrawal of the second access needle. 1. A needle set for a two needle vascular access , comprising:a first dual-lumen needle with arterial and venous ports;a second dual-lumen needle with arterial and venous ports;an arterial line with an arterial connector connected to the first and second dual-lumen needle arterial ports; anda venous line with an venous connector connected to the first and second dual-lumen needle venous ports.2. The needle set according to claim 1 , wherein the needles have blunt tips suitable for buttonhole access.3. The needle set according to wherein the arterial port(s) are connected to an annular spaced between inner and outer cannulas of the dual-lumen needle(s).4. The needle set according to wherein the arterial port(s) are connected to an annular spaced between inner and outer cannulas of the dual-lumen needle(s).5. The needle set according to wherein the dual-lumen needles have an inner cannula extending beyond an outer cannula.6. The needle set according to wherein the arterial port(s) are connected to an annular spaced between inner and outer cannulas of the dual-lumen needle(s).7. The needle set according to wherein the arterial port(s) are connected to an annular spaced between inner and outer cannulas of the dual-lumen needle(s).8. The needle set according to claim 1 , wherein the each of the first and second dual-lumen needles comprises:a first resin ...

COMPOSITE MATERIAL INCLUDING A THERMOPLASTIC POLYMER, A PEST FOOD MATERIAL AND A PESTICIDE

Composite materials that are palatable to a wood-destroying pest species and also pesticidal to the pest species can be used in pest control devices and can be used as wood substitutes for structural components, which are resistant to destruction by wood-destroying pests. The composite materials include a thermoplastic polymer, a food material for the pest and a pesticide. The composite material is formed by mixing a thermoplastic polymer, wood fragments or other cellulosic materials and a quantity of pesticide, and thereafter creating a molten material within a mixer, compounder, extruder or the like. The molten material is extruded or molded to form the desired shape. 125.-. (canceled)26. A composite material for use in pest control , the composite material comprising:a plastic structural matrix that comprises cellulose acetate butyrate (CAB);a cellulosic food material that is palatable to a pest; anda pesticide that is toxic to the pest.27. The composite material of wherein the CAB is selected from the group consisting of CAB having a degree of polymerization from about 50 units to about 400 units claim 26 , CAB having a degree of polymerization from about 100 units to about 300 units claim 26 , CAB having a degree of polymerization of about 160 units claim 26 , and a combination thereof.28. The composite material of wherein the CAB comprises (a) a mixture of CAB having from about 50 monomer units to about 75 monomer units and CAB having from about 150 to about 300 monomer units claim 26 , (b) a mixture of CAB having about 60 monomer units and CAB having about 300 monomer units claim 26 , or (c) a mixture of CAB having about 64 monomer units and CAB having about 160 monomer units.29. The composite material of wherein the CAB comprises a mixture of CAB having a molecular weight of about 16 claim 26 ,000 and CAB having a molecular weight of about 40 claim 26 ,000.30. The composite material of wherein the plastic structural matrix further comprises at least one ...

Display backlighting apparatus

An image illumination apparatus for backlighting a portion of a liquid crystal display. The apparatus includes a light source generating an illuminating light, a light shielding medium located between the light source and a display grid, and an aperture formed in the light shielding medium for allowing the transmission of light generated by the light source to pass to a lighted portion of the display grid. The light shielding medium prevents light from being transmitted to a non-lighted portion of the display grid.

Eye tracking/HUD system

In a preferred embodiment, an apparatus for eye tracking, including: an illuminator; reflection apparatus to reflect illumination from the illuminator onto a surface of a windshield of a vehicle in which the windshield is installed, such that the illumination is reflected onto at least an eye of a person in the vehicle, and to reflect an image of the at least an eye, and a sensor to receive a reflection of the image of the at least an eye reflected by the reflection apparatus and to produce an output signal representative thereof.

Inflatable imbibed polymer devices

The present invention provides a stretchable material suitable for use in an inflatable medical device. The stretchable material has at least one reinforcing polymer layer with a top and bottom side forming a porous matrix which is imbibed with a sealing material to infiltrate and substantially seal spaces of the porous matrix and extend beyond the reinforcing polymer layer to form a surface coating.

Apparatus and method for thermal detection

A thermal detecting device (20) for sensing temperature at multiple locations (62, 64) proximate to the detecting device is provided. The detecting device (20) has a pair of infrared detectors (32, 34) each configured to measure temperature of two locations (62, 64) by receiving infrared energy of the two locations (62, 64). A housing (22) encloses the pair of infrared detectors (32, 34). The housing (22) is configured with an aperture (24) to allow the infrared energy of the two locations (62, 64) to be received by the pair of infrared detectors (32, 34). A reflective mirror or two mirrors (30A, 30B) focus the infrared energy of the two locations (62, 64) towards the pair of infrared detectors (32, 34). The detecting device (20) may be configured to determine if there is a temperature differential at a location as the housing (22) moves with respect to the location.

Calibrated replacement torque rod

A torque rod replacement assembly which includes ball joint assemblies, each having a projection arm, one of which telescopes into the other, weld slots .Iadd.or windows .Iaddend.being provided for permanent assembly, and graduation being provided on the telescoping parts to facilitate accurate adaptation to a vehicle being serviced.

Calibrated replacement torque rod

A torque rod replacement assembly which includes ball joint assemblies, each having a projection arm, one of which telescopes into the other, weld slots being provided for permanent assembly, and graduation being provided on the telescoping parts to facilitate accurate adaptation to a vehicle being serviced.

Monolithic detector construction of photodetectors

Photodetector single-element and multi-element arrays of the photovoltaic type are fabricated by photoetching and sensitizing a large semi-conductor PN junction wafer for delineating the desired active junctions. An evaporated coating of dielectric material is supplied covering only a small portion of each active element and then followed by a metallic coating which makes ohmic contact with the active elements. The entire region except for the external lead pattern is then passivated with a coating of dielectric material. A metallic coating is then applied to overlay the ohmic contact areas of the active element. The wafer is then diced into individual detectors or arrays which are mounted on substrates and external leads are then connected to the external lead pads. This construction then allows for the application of interference filters, apertures stops, coded reticles, and/or guard rings to each detector element.

Surgical adhesives mixing and dispensing implement

An apparatus for mixing and dispensing a surgical adhesive having at least two components has a barrel with a central longitudinal axis extending from a first to a second end thereof. The second end includes a nozzle with a discharge port. A rotatable screw conveyor shaft extends through the barrel position along the longitudinal axis. A dispensing element is mounted within the barrel and has a threaded bore for operative engagement with the screw shaft. The dispensing element has a keyway and may freely rotate at the first end of the barrel. A snap element is included to move the dispensing element into engagement with a key on the inner surface of the barrel which prevents the rotation of the dispensing element and causes the dispensing element to move from the first end of the barrel to the second end dispensing the adhesive.

Antibodies against CD73 and uses thereof

The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.

Low energy and heat transfer crust breaking system

A pneumatic control system is provided for selectively controlling movement of a pneumatically-operated device (20) between first and second working positions. The pneumatically-operated device (20) includes a working portion (30) and a pneumatic-control portion (32). The pneumatic-control portion (32) is in fluid communication with a pressurized fluid source (26) and includes a series of valves (64,66,70) for selectively manipulating the working portion (30) between the first and second working positions. The pneumatic-control portion (32) further includes a sensing system (56,58) for holding the working portion (30) in a static mode by selectively applying system pressure to the working portion (30). In this manner, a more energy efficient system is provided by eliminating the need for continuous application of full line pressure.

Table tennis ball serving apparatus

A table tennis ball serving apparatus having a hopper which feeds tennis balls at any desired rate to a nozzle where the balls are deposited on a pad on the opposite side of which is a rotating wheel which engages the ball and ejects it with spin thereon in the same manner as an opponent returns a shot in table tennis. The rotating wheel is so mounted on the nozzle that all kinds of spin from full overspin to full underspin may be effected on the table tennis balls ejected by the apparatus.

Low-energy and non-heat transferring crust breaking system

A pneumatic control system is provided for selectively controlling movement of a pneumatically-operated device between first and second working positions. The pneumatically operated device includes a working portion and a pneumatic-control portion. The pneumatic-control portion is in fluid communication with a pressurized fluid source and includes a series of valves for selectively manipulating the working portion between the first and second working positions. The pneumatic-control portion further includes a sensing system for holding the working portion in a static mode by selectively applying system pressure to the working portion. In this manner, a more energy efficient system is provided by eliminating the need for continuous application of full line pressure.

Monolithic construction of photodetectors

Terminal for libraries and the like

A library terminal permits a user to execute a loan transaction without assistance. The library terminal (i) provides a visible scan line from a bar code reader indicating the correct positioning of the bar code on a circulating item, (ii) leads a user through a loan transaction, (iii) provides an explicit feedback to a user when an article has an improper position on the article receiving area, (iv) both checks out and checks in cir-culating items, (v) stores fonts in bit maps of screen displays instead of in a separate font memory, (vi) integrates a security marker reader, a printer, and a controller in the same housing, (vii) processes financial transactions related to the borrowing of circulating items, and/or (viii) displays actions for helping the user to correct errors in use of the terminal.

Ultrasound imaging system with common-mode noise rejection probe

An ultrasonic imaging system probe with an even-number of transducer elements, has a transformer for coupling the received signal from each transducer to an associated cable. The polling of the transformer primary windings are identical while the polling of the secondary windings of the transformer alternate, i.e. are reversed for all even-numbered channels, with respect to odd-numbered channels. All odd channel outputs are conected to a first signal bus, while all even channel outputs are connected to a second signal bus. The signal busses are connected to inputs of a differential-input amplifier, having an output which provides the sum of all channel transducer outputs, with suppression of any common-mode signal appearing in the system from the channel transformer secondary windings to the differential amplifier inputs.

Self-anchoring mast for deploying a high-speed submersible mixer in a tank

A self-anchoring mast for deploying a high-speed submersible mixer in a tank includes operably connected first and second mast members ( 20, 22 ) and a foot member 46 operably connected to the second mast member for supporting the mast in a tank. The second mast member includes a track ( 36, 38 ) for slidably receiving a bearing of the mixer to change the orientation of the mixer in the tank.

Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses

Abstract A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.

Closure and tapping construction

Method of creating a wrapped balloon, which is not shortened

Un método de crear un globo que no se acorta con presiones de explosión incrementadas, comprendiendo dicho método: a) envolver un núcleo de alambre con al menos un material de globo anisotrópico helicoidalmente orientado para formar una preforma de globo; b) exponer a calor el material de globo anisotrópico helicoidalmente orientado; c) separar el núcleo de alambre; d) exponer la preforma del globo a una presión interna a una temperatura de reflujo; e) inflar la preforma de globo para formar un globo a medida que se continúa exponiendo a dicha presión interna a una temperatura incrementada; y f) eliminar calor y la presión interna; en el que el núcleo de alambre de la etapa (a) se envuelve con al menos dos estratos helicoidalmente envueltos del material de globo, en direcciones opuestas, cada una con un ángulo de envoltura menor que 15 grados con respecto al eje longitudinal. A method of creating a balloon that does not shorten with increased burst pressures, said method comprising: a) wrapping a wire core with at least one helically oriented anisotropic balloon material to form a balloon preform; b) exposing the helically oriented anisotropic balloon material to heat; c) separating the wire core; d) exposing the balloon preform to internal pressure at a reflux temperature; e) inflating the balloon preform to form a balloon as it continues to be exposed to said internal pressure at an increased temperature; and f) removing heat and internal pressure; wherein the wire core of step (a) is wrapped with at least two helically wrapped layers of balloon material, in opposite directions, each with a wrap angle less than 15 degrees with respect to the longitudinal axis.

Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses

A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccinations.

Process for removing so.sub.2 from effluent gases and for removing heat stable salts from systems in which they accumulate

EFFLUENT GASES AND FOR REMOVING HEAT STABLE SALTS FROM SYSTEMS IN WHICH THEY ACCUMULATE ABSTRACT OF THE DISCLOSURE Improvement in processes for the selective removal of sulfur dioxide with respect to carbon dioxide from a gas mixture containing same wherein the gas mixture is contacted with an aqueous absorbent solution, such as an alkanolamine, an alkali metal or ammonium hydroxide, or sulfites thereof, to remove sulfur dioxide from the gas mixture and form a S02-rich aqueous absorbent solution which is moved to a stripping zone where sulfur dioxide is driven off to form a S02-depleted aqueous absorbent solution which is recycled and re-contacted with the gas mixture, the improvement comprising removing sulfur oxyanions of heat stable salts which accumulate in the aqueous absorbent solution by contacting it with an anion exchange resin having bisulfite anions displaceable by the heat stable sulfur oxyanions whereby the bisulfite anions of the resin are replaced by the heat stable divalent sulfur oxyanions which are thus taken out of the solution. The anion exchange resin preferably is a weak base anion exchange resin which can be regenerated by contacting it with aqueous ammonium hydroxide to replace the heat stable sulfur oxyanions on said resin with hydroxyl anions and thereafter contacting the resin with aqueous-sulfur dioxide to replace the hydroxyl anions with bisulfite anions.

Construction of west nile virus and dengue virus chimeras for use in a live virus vaccine to prevent disease caused by west nile virus

The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.

Low sulfur content, fly ash free hot reducing gas production using calcium oxide desulfurization

ABSTRACT OF THE DISCLOSURE A process and apparatus for producing a low sulfur content, fly ash free hot reducing gas by desulfurizing hot reducing gas by contacting the sulfur-bearing and fly ash containing hot reducing gas with a moving bed of a particulate calcium oxide desulfurizing agent to thereby produce a product gas stream and a byproduct calcium sulfide composition, and then recovering sulfur from the calcium sulfide composition by contacting the calcium sulfide composition with hot liquid water at a temperature and corresponding pressure sufficient to maintain steam in the system and wherein a major portion of the calcium sulfide composition has a particle size of less than about 6 mesh to thereby convert the sulfide to calcium hydroxide and hydrogen sulfide.

PROCEDURE FOR DISTILLATION OF COMBUSTIBLE GASES

Bioresistant cellulose ethers

BIORESISTANT CELLULOSE ETHERS ABSTRACT OF THE DISCLOSURE . Cellulose ethers which are resistant to enzyme catalyzed hydrolysis can be prepared by using a mixture of sodium and lithium hydroxides as the catalysts in conjunction with etherification re-agents, such as, epoxides or alkyl halides. S P E C I F I C A T I O N

Horseshoe

Apparatus for continuous calcination of gypsum

Sheet-transporting assembly

A sheet-transporting assembly including a continuous suction conveyor which operates continuously to carry previously die-cut and stripped cardboard blanks to a predetermined location whereat a vertically reciprocal grid system activated by an automatic signal operates to separate the said blanks from the conveyor and deposits the blanks upon a descending pallet elevator system.

Terminal for libraries and the like

A library terminal permits a user to execute a loan transaction without assistance. The library terminal (i) provides a visible scan line from a bar code reader indicating the correct positioning of the bar code on a circulating item, (ii) leads a user through a loan transaction, (iii) provides an explicit feedback to a user when an article has an improper position on the article receiving area, (iv) both checks out and checks in cir-culating items, (v) stores fonts in bit maps of screen displays instead of in a separate font memory, (vi) integrates a security marker reader, a printer, and a controller in the same housing, (vii) processes financial transactions related to the borrowing of circulating items, and/or (viii) displays actions for helping the user to correct errors in use of the terminal.

Method and composition for reducing the strength of ice

ABSTRACT OF THE DISCLOSURE This invention is directed to the reduction of the strength of ice in association with solid particulate materials, such as, for example, coal, by applying to the solid particulate material, prior to exposure to water freezing conditions, a composition comprising a mixture of a hydrocarbon liquid and an ethoxylated aliphatic primary or secondary alcohol containing 1 to 7 oxyethylene units and 7 to 20 carbon atoms in the alkyl portion thereof. The composition may also contain an oil soluble alkyl ether of a glycol derived from ethylene oxide and/or propylene oxide and containing from 1 to 3 oxyalkylene units.

Table tennis ball server robot and net

A table tennis ball serving assembly (1) is mounted to a table by a quick release, foldable net attachement assembly (5). Server (1) includes a container (13) and a robot server (3) mounted therein. Trough assembly (19, 21) is mounted to and extends out laterally from the container (13). Net assembly (5) surrounds the robot server (3). Net assembly (5) contains a rear ball-impervious net (41) and a forward net (53) designed to allow balls striking the forward net (53) at a predetermined velocity to pass through, strike the rear net (41) and drop into trough assembly (19, 21). Balls striking the forward net (53) with insufficient velocity drop into the trough assembly (19, 21). Side wing nets (8') may be provided to extend along each side to the mid-point of the table. A pair of removable ball dams (25) in the trough assembly create a ball storage area. Holes (24) of predetermined size in the dams serve as a gauge for ball sizing. The robot server (3) includes a robot (207) that can be removably mounted to the front or rear of a ball holding tray or container (203).

Two zone infrared ranging system

An economical dual zone active rangefinding system for a photographic camera operates upon the principle of triangulation without lateral displacement of either the radiation source or detector to provide an output signal indicative of whether the subject in the scene to be photographed is located in a select distance range from the photographic camera.

Linear actuator

Terminal for libraries and the like

A library terminal permits a user to execute a loan transaction without assistance. The library terminal (i) provides a visible scan line from a bar code reader indicating the correct positioning of the bar code on a circulating item, (ii) leads a user through a loan transaction, (iii) provides an explicit feedback to a user when an article has an improper position on the article receiving area, (iv) both checks out and checks in circulating items, (v) stores fonts in bit maps of screen displays instead of in a separate font memory, (vi) integrates a security marker reader, a printer, and a controller in the same housing, (vii) processes financial transaction related to the borrowing of circulating items, and/or (viii) displays actions for helping the user to correct errors in use of the terminal.

Vehicle turning assist system and method

A turning maneuver assist system and method are provided for assisting the driver of a vehicle with a visual image while turning the vehicle. The system includes first and second cameras positioned to generate video images on respective first and second sides of the vehicle. The system also includes a drop-down display located onboard the vehicle for displaying images generated by the first and second video cameras. The system further includes a controller for controlling activation of the first and second cameras and the presentation of images on the display. The controller activates one of the first and second cameras and controls the display to output images captured by the activated camera when the vehicle is determined to be turning. The display is mounted forward and above the driver and moves between a stowed position and a viewable position.

Vehicular rear view mirror/video display

A rear view mirror/video display includes a one-way mirror and a selectively activated video display that is mounted immediately behind the one-way mirror so that the driver is presented with a typical semi-obstructed rearward view when the video display is deactivated, and an unobstructed rearward view of substantially the same size and aspect ratio when the video display is activated. The video image is obtained from an imaging device mounted to capture a rearward field-of-view that is unobstructed by vehicle body panels but otherwise corresponds in content with that of the image reflected by the one-way mirror. Activation and deactivation of the video display may be manual, but is preferably automatic based on vehicle operating conditions.

School bus stop sign and crossing arm apparatus

School Bus Stop Sign and Crossing Arm Apparatus Abstract An electrically-powered school bus sign and crossing arm apparatus mounts on the school bus body. A uni-directional DC motor and associated linkage and limit switch controls are used to deploy and retract the stop sign blade and crossing arm.

Dispensing system

Floor sanding machine

Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses

Low-energy and non-heat transferring crust breaking system

Electrochemical reductions of cyanopyridine bases

Improved electrochemical reductions of cyanopyridine bases in which the reduction is performed by electrolysis in an ion-exchange membrane-divided flow cell at a lead dioxide cathode and in an aqueous or partly aqueous medium comprising sulfuric acid in at least a 1:1 mole ratio with the cyanopyridine base. In the case of 2- and 3- isomers, an iron salt is also added to the catholyte as a catalyst. In the case of the 4- isomer, an efficient, semi-continuous batch process is reported. With all bases, significant advantages of a commercial and industrial nature are reported over prior art static, beaker cell technology.

Method and apparatus for accessing local storage within a parallel processing computer

A processor within a parallel processing computer having a plurality of processors, where each processor is directly connected to a local storage memory. Each processor contains a principal processing element (PPE), a memory controller, and a multiplexor. The PPE executes a series of program instructions including local storage memory access instructions that cause the PPE to produce a local storage memory access request for accessing information within the local storage memory. The memory controller is connected to the PPE and a plurality of information resources of the parallel processing computer. This controller selectively routes local storage memory access requests from the information resources to an output port of the memory controller and generates an enable flag that is set to a first state when a selected one of the plurality of information resources can access the local storage memory and is set to a second state when the PPE is accessing the local storage such that access by the information resources is deferred until access by the PPE is complete. The multiplexor is connected to the PPE, the memory controller and the local storage memory. The multiplexor, operating in response to the enable flag, multiplexes the PPE access request with the selected information resource access requests such that access by the PPE to the local storage memory occurs substantially without time-delay interruption of the execution of program instructions by the PPE.

Valve

Method of preparing tin-free, chromium coated steel

Filter press electrochemical cell with improved fluid distribution system

A filter press electrochemical cell with an improved fluid distribution system for even distribution of electrolyte between cell units when connected in parallel, and from side to side and across the thickness of reaction chambers in individual cells regardless of whether parallel or series flow connection is used. Each preferred cell unit comprises two electrodes and a fluid distributor plate having at least two first holes (12) therein and channel portions (24) including diverging walls (27) connecting these holes with opposite sides of a central cell opening (15) in each plate. Preferred configurations of the triangular-shaped channel opening thereby formed permit distribution of fluid without complicating barrier structures or other constrictions in the fluid path such as used in prior art cells. Preferred and alternate cell arrangements and configurations are disclosed.

1,3-dioxolan-4-yl-alkyl amines