МОДУЛЬНЫЙ АППАРАТ ДЛЯ ГЕМОФИЛЬТРАЦИИ С ИНТЕРАКТИВНОЙ СИСТЕМОЙ УПРАВЛЕНИЯ С ВОЗМОЖНОСТЬЮ ВВОДА ИНСТРУКЦИЙ ОПЕРАТОРА

Изобретение относится к области медицины. Аппарат для осуществления терапии крови содержит блок управления, имеющий кровяной насос и несколько жидкостных насосов, закрепляемых на указанном блоке, и контроллер, выполненный с возможностью управления указанным кровяным насосом и жидкостными насосами, и интерактивную операторскую систему управления с экраном операторского интерфейса, находящимся в рабочем соединении с контроллером. Контроллер содержит программное обеспечение, способное управлять указанным аппаратом в ответ на выбор оператором вводимых команд. Аппарат содержит сменный набор панелей, включающий три отдельные панели, выполненные с возможностью ручного закрепления и ручного удаления их с указанного блока управления. Кровяная панель содержит установленные на ней и закрепленные трубки подачи крови. На жидкостной панели размещены и закреплены трубки подачи жидкости. Панель картриджа фильтра прикреплена к кровяной и жидкостной панелям. Панель картриджа фильтра включает сменный картридж ...

СПОСОБ И УСТРОЙСТВО ДЛЯ ГЕМОДИАФИЛЬТРОВАЛЬНОГО ПРИЕМНО-ВЫВОДНОГО МОДУЛЯ

Изобретение относится к способу и устройству для гемодиафильтровального приемно-выводного модуля. Устройство включает диализный аппарат, контур искусственного кровообращения, сообщающиеся с диафильтровальным модулем, содержащим первый трубопровод (120), предназначенный для приема первой жидкости из диализного аппарата и для выпуска диализной жидкости в указанный аппарат, второй трубопровод (64), селективно сообщающийся с первым трубопроводом с обеспечением селективного поступления во второй трубопровод отводимого количества первой жидкости из первого трубопровода. Второй трубопровод сообщается, по меньшей мере, с одним стерилизационным фильтром (92) для создания замещающей жидкости, подаваемой в контур искусственного кровообращения. Блок управления (110) действует от параметров жидкости, а именно первой жидкости и диализной жидкости, и/или от параметра крови, находящейся в контуре искусственного кровообращения. Блок управления выполнен с обеспечением предотвращения поступления потока замещающей ...

УСТРОЙСТВО ДЛЯ ОЧИСТКИ КРОВИ

... 1. Устройство для очистки крови для использования в системе очистки крови, содержащееочиститель крови, внутренний объем которого разделяется на канал для потока крови и канал для другого потока, причем очиститель крови имеет первую входную часть, соединенную с одним концом канала для потока крови, первую выходную часть, соединенную с другим концом канала для потока крови, вторую входную часть, соединенную с одним концом канала для другого потока, и вторую выходную часть, соединенную с другим концом канала для другого потока;артериальный контур, связанный с первой входной частью;венозный контур, связанный с первой выходной частью;контур диализата, связанный со второй входной частью;контур текучих отходов, связанный со второй выходной частью и через который проходят текучие отходы от второй выходной части;первый контур, связанный с венозным контуром и через который проходит первая текучая среда; ивторой контур, связанный с артериальным контуром, венозным контуром или первым контуром и через ...

ГЕМОДИАФИЛЬТРОВАНЫЙ/ГЕМОФИЛЬТРОВАНЫЙ КАРТРИДЖ

... 1. Гемодиафильтровальный/гемофильтровальный картридж с промежуточным разбавлением, содержащий корпус, имеющий первый торец и противоположный второй торец и сообщающийся с впуском для крови, выпуском для крови и впуском и выпуском для диализата, первую ступень гемодиафильтрации, включающую первый фильтрующий элемент, расположенный между первым и вторым торцами корпуса картриджа, причем впуск для крови сообщается с первым фильтрующим элементом у первого торца с обеспечением протекания крови через указанный фильтрующий элемент в сторону второго торца, вторую ступень гемофильтрации, включающую второй фильтрующий элемент, расположенный между первым и вторым торцами корпуса картриджа, причем выпуск для крови сообщается со вторым фильтрующим элементом, и межступенчатый соединитель, расположенный у второго торца корпуса картриджа, ограничивающий межступенчатую коллекторную полость, обеспечивающую протекание крови, выпущенной из первой ступени гемодиафильтрации, через второй фильтрующий элемент ...

VORRICHTUNG ZUR AUSSERKÖRPERLICHEN BLUTBEHANDLUNG

Dialysis soln. for use with artificial kidneys - contains low calcium ion content, but high citrate content to inhibit coagulation of blood

A dialysis soln. for use with artificial kidneys contains at most 0.2 mMol/l la and 5-55 mMol/l citrate ions and 130-165 mMol/l Na ions. A device for dialysis treatment with artificial kidneys consists of a dialysis cell (3), a conveyor pump (8) for the patients blood and a conveyor pump (9) for the dialysate soln. A dosing pump (6) is situated in pipe (15) for recycling blood after the dialysis cell (3). This pump adds Ca2+ and/or Mg2+ ions from a container to the patients blood. USE/AVANTAGE - The high citrate ion content ensures that citrate ions diffuse into the blood and act in the membrane filter as anticoagulants. The citrate ions are degraded in the body by the Krebs cycle. Citrate intoxication is prevented by ensuring that the content of free ionised Ca is low and the Ca2+ is continuously added to the blood after the dialysis. Thus the use of heparin is avoided.

Flushing equipment for extracorporeal blood-treatment circuit

The circuit has an arterial hose system leading from the patient to the blood-treatment unit and containing a blood-pump. A venous hose system leads back to the patient from the unit and contains a drop chamber or pipe junction. A flushing-solution bag is connected by a first pipe with low flow-resistance to the arterial hose system upstream of the pump, and the pipe can be shut off by a clamp or valve. A second pipe with high flow resistance connects the bag to a substitute source, and can be of the capillary type (364). Alternatively, it can comprise a section of low flow-resistance in series with one of high resistance, the latter typically consisting of a sterile filter. Flow resistance can be adjustable by a clamp, and the bag can be enclosed between two plates, the distance between which is adjustable.

Verwendung eines Dialysators mit zwei Modulen zur Durchführung eines Verfahrens zum Filtrieren und sofortigen Verwenden von Substituatflüssigkeit in einer Hämodialfiltrationsvorrichtung

Method of removing blood from extracorporeal blood circulation for treatment device for extracorporeal blood treatment of patient after completing blood treatment session, involves introducing substitute fluid in extracorporeal circulation

The method involves introducing substitute fluid in an extracorporeal circulation (1000). The substitute fluid is conveyed for simultaneous discharge of blood both from an arterial line section (1) and from a venous line section (3) of the extracorporeal blood circulation. The blood is conveyed under simultaneous operation of a blood pump (13) and a conveyor from the extracorporeal circulation. Independent claims are also included for the following: (1) a treatment device with a storage unit; and (2) a tubing system for use in blood removing method.

Dialysemaschine

Dialysevorrichtung und Verfahren zum Reinigen und Befüllen derselben

APPARATUS FOR AN METHOD OF REMOVING SUBSTANCES INTENDED FOR EXCRETION IN THE URINE FROM BLOOD

... 1471936 Ultrafiltration of blood SARTORIUS-MEMBRANFILTER GmbH 21 May 1974 [5 July 1973] 22519/74 Heading B1X An apparatus for removing substances, destined for excretion in the urine, from blood comprises an ultrafiltration unit 40 having a blood inlet 44 and outlet 47 which are incorporated in the circulating system of the blood, an ultrafilter (ultrafiltration diaphragm) 41 having a pore size suitable for the passage only of molecules having molecular weights below 2000, and a waste outlet 60 for discarding the ultrafiltrate, and means coupled to the blood outlet 47 only for storing 86 and supplying, via low pressure pump 84 and pipe 82, a blood-regenerating solution for making good with respect to volume and constituents at least part of any fluid abstracted by the ultrafilter unit from the blood when the apparatus is in use. The ultrafilter may consist of capillary tubes (e.g. "Permasep" hollow nylon fibres). In a method for removing substances from non-human blood, as above, the solution ...

Modular home dialysis system - debubblers

An apparatus for removing air bubbles from blood is disclosed. The debubbler comprises front and rear covers (1002, 1008 respectively) with a fluid circuit board (1004) arranged between the two covers. A blood chamber is defined between cover (1002) and circuit board (1004) and an air chamber is defined between covers (1008) and circuit board (1004). A microporous membrane (1006) separates the blood and air chambers. A support means (1024) supports membrane (1006) from the air side of the membrane. A blood pressure sensor is provided between covers (1002, 1008). The debubbler has a blood inlet port (1022) and a blood outlet port (1020) for conducting blood to and from the blood chamber. An air port (1012) is provided in communication with the air chamber, to allow air passing through membrane (1006) to escape.

Modular home dialysis system

BLOOD CLEANING SYSTEM

DEVICE TO HEMODIALYSIS

H�MOFILTRATIONSSYSTEM

SUPPORTING ELEMENT FOR AN INTEGRATED BLOOD TREATMENT MODULE

TWO-STAGE FILTER CARTRIDGE

VALVE MECHANISM F�R OF INFUSION FLUID SYSTEMS

EXTRAKORPORALE BLOOD TREATMENT MACHINE

DEVICE FOR EXTRAKORPORALEN BLOOD TREATMENT

IONISCH IMPROVING DIALYSIS/CFILTRATION SYSTEM

BLOOD TREATMENT EQUIPMENT AND SOFTWARE PROGRAM FOR INFUSION CONTROL

K�NSTLICHE KIDNEY AND CONTROL PROCEDURE.

BLUTSAEUBERUNGSGERAET.

H�MODIALYSEGER�T

DEVICE AS A CHECK OF THE SODIUM CONCENTRATION OF A DIALYSATS AFTER REGULATION

DIAPHRAGM MODULE TO HEMODIAFILTRATION WITH INTEGRATED VORODER NACHVERDÜNNUNG THE BLOOD

On demand and post-treatment delivery of saline to a dialysis patient

Apparatus for use in a dialysis system are disclosed including an apparatus- for delivering saline during dialysis treatment, an apparatus for delivering saline to a patient after dialysis treatment has ended, and an apparatus for alerting a patient that dialysis treatment is about to end. In the apparatus for delivering saline during dialysis treatment, a controller is configured to automatically deliver saline in response to a request. In the apparatus for delivering saline to a patient after dialysis treatment has ended, a controller is configured to automatically deliver saline after dialysis treatment has concluded, but before the patient is disconnected in response to a request. In the apparatus for alerting a patient that dialysis treatment is about to end, a controller is configured to monitor a dialysis treatment and activate an alarm when treatment is about to end.

Device and method for detecting recirculation during an extracorporeal blood treatment

The invention relates to a device and a method for detecting recirculation for an extracorporeal blood treatment device, and to an extracorporeal blood treatment device having a device for detecting recirculation. The device according to the invention and the method according to the invention are based on a targeted haemodilution by administering a bolus of a substitution fluid (substituate), which leads to a change in the pressure conditions in the venous and arterial branches (6, 7) of the extracorporeal circuit as a result of a change in the viscosity of the fluid flowing in the extracorporeal blood circuit (5A). Recirculation is determined by detecting the pressure change in the extracorporeal circuit. The device for detecting recirculation has a control unit (17), which cooperates with the blood conveying device (8) in the blood treatment device and with the substituate conveying device (16) in the blood treatment device. The control unit (17) provides an operating mode for detecting ...

Priming system and method for dialysis systems

Apparatuses and processes for whole-body hyperthermia

Multistage hemodiafiltration/hemofiltration method and apparatus

TECHNIQUE FOR EXTRACORPOREAL TREATMENT OF BLOOD

A method for priming a circuit for multiple blood extracorporeal treatments, the circuit comprising : a filtration unit (40) having a primary and a secondary chamber (44, 46) separated by a semipermeable membrane (42) ; a primary circuit comprising a blood access line (34) connected to an inlet of the primary chamber (44) and a blood return line (35) connected to an outlet of the primary chamber (44) ; a collection fluid line (82) connected to the outlet of the secondary chamber (46) the method comprising the steps of : circulating a priming fluid from an end of the blood return line (35) to an end of the blood access line (34) and through the primary chamber (44) for a predetermined priming time ; and when the primary circuit (34, 35) is filled with priming fluid, ultrafiltering priming fluid from the primary chamber (44) into the secondary chamber (46) and circulating priming liquid from the secondary chamber (46) to an end of the collection fluid line (82).

APPARATUSES AND PROCESSES FOR WHOLE-BODY HYPERTHERMIA

Apparatuses for use in whole-body hypothermia include a high-flow hyperthermia circuit coupled to a low-flow dialysis circuit in a manner which reduces tensioning of membranes in the dialyzer (152) of the dialysis circuit. The arrangement thereby allows proper membrane movement to assist in mixing a sorbent suspension (176) circulated on the sorbent side of the dialyzer. Additional dialysis apparatuses include advantageous disposable packs (300) including the dialyzer (152), sorbent heat exchangers (186) arranged to cooperate with heating elements on base units of the apparatuses, and adaptations for very high flow rates useful in the hyperthermic treatment of cancers.

GAS SEPARATION DEVICES

A description is given of a gas separation device for a physiological fluid, comprising a containing body (6) having at least a first inlet aperture (7) for a physiological fluid, positioned with a tangential direction of access, at least one outlet aperture (9) for the said fluid, spaced apart from the said inlet aperture, and a guide element (17) housed within the said body. The guide element (17) has a continuous active surface (15) designed to contact and guide the said fluid and delimits, together with the containing body (6), a first annular chamber (20) into which the first inlet aperture (7) opens directly.

EXTRACORPOREAL BLOOD PURIFICATION DEVICE

The invention concerns an extracorporeal blood purification device comprising a blood extracting duct (1), a blood return duct (3), blood filtering means (4), a duct evacuating ultrafiltrate (5) coming from the filtering means (4), a substituting solution source (S), two connecting ducts (7',7") between said source (S) and said blood extracting duct (1) and said blood return duct (3). The device further comprises means for measuring (10-13) at least one of the parameters affected by the filtering means (4) resistance to the liquid flow, means for determining at least a threshold value of said parameter, means for comparing said parameter with said threshold value, exchange control means for calculating the distribution between the respective flow rates through said connecting ducts (7',7"), capable of reducing the difference between said value of said measured parameter and said threshold value.

TECHNIQUE FOR EXTRACORPOREAL TREATMENT OF BLOOD

A method for priming a circuit for multiple blood extracorporeal treatments, the circuit comprising : a filtration unit (40) having a primary and a secondary chamber (44, 46) separated by a semipermeable membrane (42) ; a primary circuit comprising a blood access line (34) connected to an inlet of the primary chamber (44) and a blood return line (35) connected to an outlet of the primary chamber (44) ; a collection fluid line (82) connected to the outlet of the secondary chamber (46) the method comprising the steps of : circulating a priming fluid from an end of the blood return line (35) to an end of the blood access line (34) and through the primary chamber (44) for a predetermined priming time ; and when the primary circuit (34, 35) is filled with priming fluid, ultrafiltering priming fluid from the primary chamber (44) into the secondary chamber (46) and circulating priming liquid from the secondary chamber (46) to an end of the collection fluid line (82).

SYSTEM AND METHOD FOR DELIVERY OF REGIONAL CITRATE ANTICOAGULATION TO EXTRACORPOREAL BLOOD CIRCUITS

LIVER SUPPORT SYSTEM

The present disclosure relates to an artificial, extracorporeal system for liver replacement and/or assistance, comprising a liver dialysis device for conducting hemodialysis on a patient suffering from liver failure, which is characterized in that it comprises a first standard hollow fiber membrane dialyzer which does not allow passage of an essential amount of albumin over the membrane wall and which is perfused with the patient's blood, and a second hollow fiber membrane dialyzer which allows the passage of essential but defined amounts of albumin over the membrane wall and which receives the blood of the first standard hemodialyzer and wherein the filtrate space is closed off from the lumen space of the hollow fibers and is populated by adsorbent material which may comprise one or more different adsorbents.

Modular Home Dialysis System

ARTIFICIAL KIDNEY AND A METHOD OF CONTROLLING IT

The artificial kidney comprises: an exchanger having two compartments separated by a semipermeable membrane, a first compartment being connected to a circuit for conveying a flow of blood outside the body; a source of sterile liquid suitable for connection either to the circuit for conveying a flow of blood outside the body or else to an inlet to the second compartment of the exchanger; and control means for connecting the source of sterile liquid either to the inlet of the second compartment of the exchanger or to the circuit for conveying a flow of blood outside the body, as a function of the value of the transmembrane pressure. This kidney provides optimum purification treatment for patients suffering from temporary kidney failure. -21- ...

MODULAR HOME DIALYSIS SYSTEM

A machine for conducting dialysis of body fluids of a patient. The machine includes integral water preparation and treatment, dialysate preparation, and extracorporeal circuit modules, under computer control from a patient interface and control module. A water pretreatment module with a temperature-controlled mixing valve, an integral water filtration and conditioning unit and a pressure relief with integral water sample removal port supplies water to the machine. The dialysate preparation module includes a substantially non-compliant tank with attached batch chemical bottles and automatic chemical addition and dispersion subsystems. The machine incorporates novel automatic process control techniques to verify the status and integrity of the critical system components, ultrafiltration control, and temperature, pressure and conductivity conditions prior to dialysis.

УСТРОЙСТВО ДЛЯ ДИАЛИЗА

Изобретение относится к устройству (1) для диализа, содержащему циркуляционный контур диализата, который включает в себя первый диализатор (3) и второй диализатор (5), при этом первый диализатор (3) выполнен с возможностью соединения с системой кровообращения пациента через подвод (11) для крови и отвод (13), и предусмотрен отвод для потока (Qefluent) остающейся фракции из циркуляционного контура диализата во втором диализаторе (5), а поток (Qout) пермеата второго диализатора (5) направляют в циркуляционном контуре диализата в первый диализатор (3). При этом второй диализатор (5) содержит мембранный фильтр с величиной границы пропускания по меньшей мере 500 Да, а первый диализатор (3) содержит мембранный фильтр с более высокой величиной границы пропускания, чем у второго диализатора (5).

Device for injecting sterile apyrogen liquid and method for inspecting main filter

APPARATUS OF DIALYSIS ALLOWING TO CONTROL, Independently, CONCENTRATION Of AT LEAST TWO IONIC SUBSTANCES IN the INTERIOR MEDIUM Of a PATIENT

Appareil de dialyse comprenant : - des moyens (12, 13, 25, 26) pour mettre en circulation dans un hémodialyseur (1) un liquide de dialyse contenant du chlorure de sodium et du bicarbonate de sodium; - des moyens (9, 12) pour perfuser à un patient au moins une solution contenant au moins une substance ionique A absente du liquide de dialyse, la substance A ayant une concentration déterminée [A]sol, dans la solution de perfusion; - des moyens (29, 30, 31, 32, 33, 34, 35, 36) pour déterminer la dialysance réelle D de l'hémodialyseur (1) pour le sodium; - des moyens (36) pour déterminer un débit Qinf de solution de perfusion pour que la concentration de la substance A dans le milieu intérieur du patient tende vers une concentration souhaitée [A]des, des, en fonction de la dialysance D, de la concentration [A]sol de la substance A dans la solution de perfusion et de la concentration souhaitée [A]des ; - des moyens de réglage (10, 11) pour régler le débit de solution de perfusion; - des moyens ...

ARTIFICIAL KIDNEY AND PRODUCT ADAPTED FOR IMPLEMENTATION IN AN EXTRACORPOREAL BLOOD TREATMENT

DEVICE AND LINE HAVE USE SINGLE FOR THE EXTRACORPORAL TREATMENT OF BLOOD PARANTICOAGULATION TO CITRATE

DEVICE AND A METHOD FOR REGULATING THE CONCENTRATION OF SODIUM IN A LIQUID OF DIALYSIS FOR A REGULATION

Extracorporeal blood treatment device, has treatment unit with fluid inlet and fluid outlet, where inlet is in fluid communication with outlet of exchanger, and outlet is in fluid communication with inlet line

L'objet de la présente invention est la filtration de sang afin de séparer et extraire sélectivement des molécules de taille choisie par le biais de systèmes extracorporels pour la séparation de substances. Ainsi l'invention concerne un dispositif de traitement extracorporel de sang comprenant: au moins un échangeur (1) comportant au moins une première entrée (2) pour le sang à traiter, une première sortie (4) de fluide et une deuxième sortie (5) de fluide, une ligne d'entrée (10) du sang à traiter raccordée à la première entrée (2) de l'échangeur (1), une ligne de sortie (ou ligne veineuse) (11) du sang raccordée à la première sortie (4) de l'échangeur (1),au moins une unité de traitement (21) comportant au moins une première entrée (22) de fluide et au moins une première sortie (24) de fluide, la deuxième sortie (5) de l'échangeur (1) étant en communication de fluide avec la première entrée (22) de l'unité de traitement (21),caractérisé en ce que la première sortie (24) de l'unité de ...

APPARATUS Of HEMOFILTRATION ALLOWING TO CONTROL, Independently, CONCENTRATION Of AT LEAST TWO IONIC SUBSTANCES IN the INTERIOR MEDIUM Of a PATIENT

Un appareil d'hémofiltration comporte : - des moyens (20, 24, 34, 38) pour préparer une première solution injectable à partir d'au moins une solution concentrée; - des moyens (33) pour injecter, à un débit d'injection Qpre, la première solution dans la canalisation (5) de prélèvement de sang d'un circuit de circulation extracorporelle de sang (2, 5, 7, 8); - des moyens (50, 51, 52, 53) pour perfuser à un patient une deuxième solution contenant au moins une substance ionique A ayant une concentration déterminée [A] post différente de la concentration [A]pre de cette substance A dans la première solution; - des moyens (60) pour déterminer un débit de perfusion Qpost de la deuxième solution pour que la concentration de la substance A dans le milieu intérieur du patient tende vers une concentration souhaitée [A]des, en fonction de la concentration [A]post post de la substance A dans la deuxième solution, de la concentration souhaitée [A]des, du débit d'injection Qpre de la première solution ...

DEVICE AND PROCESS OF TREATMENT OF BLOOD WITH SELECTIVE EXTRACTION OF AQUEOUS SOLUTIONS

DEVICE AND PROCESS OF TREATMENT OF BLOOD WITH SELECTIVE EXTRACTION OF AQUEOUS SOLUTIONS

DEVICE AND PROCESS OF TREATMENT OF BLOOD WITH SELECTIVE EXTRACTION OF AQUEOUS SOLUTIONS

DEVICE AND PROCESS OF TREATMENT OF BLOOD WITH SELECTIVE EXTRACTION OF AQUEOUS SOLUTIONS

DIALYSIS MACHINE, A MANIFOLD FOR THE DIALYSIS MACHINE AND PROCESS

The present invention relates to a dialysis machine for the purification of blood, a manifold for the dialysis machine as well as to a process for the regeneration of the dialysis bath. It is an object of the present invention to provide a dialysis machine, a manifold for the dialysis machine as well a process which facilitates the administration of medical preparations during a dialysis procedure. In order to solve the object, a dialysis machine according to the present invention comprises tubes (1, 5, 8) connected with a dialyzer (6), means for delivering pharmaceuticals into the tubes and a pump (11) for the transport of blood through the tubes and the dialyzer. The dialysis machine comprises means for administration (4) of at least one pharmaceutical by a suction effect of the pump or by a pressure effect of the pump or by an excess pressure of a gas or a liquid.

PRIMING SYSTEM AND METHOD FOR DIALYSIS SYSTEMS

The application is directed to an extracorporeal blood processing system capable of using dialysate to prime the system. A plastic molded compact manifold supports molded blood and dialysate fluidic pathways along with relevant sensors, valves and pumps. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine. A two-way valve in the manifold is used to direct the dialysate flow through the blood circuit to prime the circuit for use in treatment.

TUBING FOR EXTRACORPORAL PURIFICATION OF THE BLOOD AND USE THEREOF

Cette tubulure comprend un conduit de circulation extracorporelle en boucle ouverte présentant deux parties, l'une d'extraction du sang à épurer (1), l'autre de retour du sang épuré (2), au moins un conduit (29, 30, 31) pour relier au moins une desdites parties (1, 2) à une source (16, 16') d'une solution de substitution, un piège à bulles (7) situé le long de ladite boucle, un conduit d'évacuation du produit rejeté (28), muni d'un segment conformé pour servir de corps de pompe et des moyens de raccordement (11) pour relier l'une à l'autre, de façon amovible, les extrémités respectives (45, 46) de ladite tubulure de circulation extracorporelle en boucle ouverte (1, 2) pour former une boucle fermée. Le conduit d'évacuation du produit rejeté (28) comporte, en aval dudit segment conformé pour servir de corps de pompe, un détecteur de sang (14), un conduit de liaison (8) s'étendant entre l'extrémité aval dudit segment conformé pour servir de corps de pompe et ledit piège à bulles (7).

PLASMA EXCHANGE WASTE LIQUID PURIFICATION CIRCULATION DIALYZER

An apparatus in which in plasma exchange therapy, valuable plasma is recycled as a dialysis solution without disposing of the same, which apparatus is operable with only some modifications applied to the conventional plasma exchange equipment. There is provided a unit for use in plasma exchange therapy characterized in that at least portion of separated plasma is purified, circulated as a dialysis solution and used to dialyze patient’s blood, thereby removing hazardous substances contained in the plasma. There are further provided a plasma exchange apparatus including the above unit and an artificial liver equipped with the apparatus.

METHOD AND DEVICE FOR INJECTING A STERILE APYROGEN LIQUID OBTAINED BY FILTRATION

Sterile apyrogen liquid injecting device obtained by filtration and method of verifying the integrity of the filter used for this purpose. The sterile liquid injecting device comprises at least one main filter (15) with first and second compartments (16, 17) separated by a porous membrane (18), the first compartment (16) having an inlet connectable to a source (11) of liquid to be filtered and the second compartment (17) having an outlet connected to an injecting tube (22); means (23) for circulating the liquid through the main filter (15) and into the injecting tube (22), and means (25, 26, 27) for verifying the main filter's integrity comprising: a secondary filter (24) capable of retaining bacteria and pyrogen elements disposed on the injecting tube (22) and means (25, 26, 27) for detecting clogging of the secondary filter (24) during injection of the liquid. Application especially where the liquid injected is dialysis liquid sterilized in line for injection as a substitution liquid.

Device and method for extracorporeal blood treatment

Disclosed are preferred devices and methods which provide extracorporeal treatment of blood to effectively and consistently remove toxins therefrom and from patients over extended periods of time.

Shear-enhanced systems and methods for removing waste materials and liquid from the blood

Systems and methods convey the blood through a gap defined between an inner surface that is located about an axis and an outer surface that is concentric with the inner surface. At least one of the inner and outer surfaces carries a membrane that consists essentially of either a hemofiltration membrane or a hemodialysis membrane. The systems and methods cause relative movement between the inner and outer surfaces about the axis at a selected surface velocity, taking into account the size of the gap. The relative movement of the two surfaces creates movement of the blood within the gap, which creates vortical flow conditions that induce transport of cellular blood components from the membrane while plasma water and waste material are transported to the membrane for transport across the membrane. Shear-enhanced transport of waste materials and blood plasma water results.

DIALYSIS SYSTEM INCLUDING CASSETTE WITH PUMPING TUBES

A hemodialysis system includes a blood treatment machine, a blood pump housed by the blood treatment machine, a first dialysate pump housed by the blood treatment machine, a second dialysate pump housed by the blood treatment machine; and a fluid cassette including an upper portion and a lower portion. The fluid cassette further includes a blood pumping tube extending from the upper portion to the lower portion of the fluid cassette, a first dialysate pumping tube extending from the upper portion to the lower portion of the fluid cassette, and a second dialysate pumping tube extending from the upper portion to the lower portion of the fluid cassette.

Method of cleaning and priming dialysis system

A dialysis system which does not need to use a physiological saline in replenishing a solution or cleaning and priming the dialysis system, does not need a troublesome setting operation and can easily and accurately set a flow rate of a replenisher solution. The dialysis system includes a closed-type water-removal control apparatus 1, a dialyzer 2, a fresh dialysate line 3 as well as a used dialysate line 4, an RO water pressurizing line 5, an RO water pressurizing pump 51 provided in the RO water pressurizing line 5, an artery side blood line 6, a blood pump 61 provided at the artery side blood line 6 and a vein side blood line 7. According to the dialysis system, by pressurizing RO water into a communication line of the used dialysate, dialysate is made to flow from a dialysate flow path 21 into a blood flow path 22 through a dialysis membrane 23 of the dialyzer 2 and the inside of a blood circulation path can be cleaned and primed.

Device and method for controlling infusion of liquid in an extracorporeal blood circuit

A dialysis machine having an extracorporeal blood circuit having an arterial pipe and a venous pipe respectively connected to an inlet and an outlet of a blood compartment of a filter having a blood compartment and a dialysis liquid compartment separated by a semi-permeable membrane; means for determining a sequence of infusion of a liquid in the extracorporeal blood circuit, from at least one characteristic value (FF, TMPave, Kuf) correlated with the concentration of the blood (CE) and/or a filtration efficiency of the filter; and means for infusing the infusion solution in the arterial pipe and in the venous pipe in accordance with the determined infusion sequence.

Dialysis system with enhanced features

A dialysis system includes a dialysis fluid cassette-based membrane blood pump; a dialyzer in fluid communication with the blood pump: first and second dialysis fluid cassette-based balance chambers each having (i) a fresh dialysis fluid compartment in fluid communication with the dialyzer and (ii) a spent dialysis fluid compartment; a dialysis fluid cassette-based fresh dialysis fluid membrane pump in fluid communication with the fresh dialysis fluid compartments of the first and second balance chambers; a dialysis fluid cassette-based spent dialysis fluid membrane pump in fluid communication with the dialyzer and the spent dialysis fluid compartments of the first and second balance chambers; and arterial and venous lines in fluid communication with the dialyzer for patient connection, the arterial and venous lines each including a contact used for electrically detecting a patient access disconnection.

Substitution infusion fluid and citrate anticoagulation

The invention relates to a substitution infusion fluid for hemofiltration of a specific composition. The use of said substitution infusion fluid significantly reduces the risk of the occurrence of abnormalities in a patient undergoing pure hemofiltration. The invention also relates to process for pure hemofiltration of blood wherein said substitution infusion fluid is used. The invention also relates to a matching citrate anticoagulation fluid of a specific composition. The invention also relates to a process for pure hemofiltration of blood wherein said substitution infusion fluid is used in combination with said citrate anticoagulation fluid. The use of said substitution infusion fluid in combination with said citrate anticoagulation fluid significantly further reduces the risk of the occurrence of abnormalities in a patient undergoing pure hemofiltration.

Multifunctional apparatus for treatment of renal insufficiency

DIALYSIS DEVICE

Apparatus for extracorporeal treatment of blood and process of calculating set flow rates in a medical apparatus for delivery or collection of fluids

Hemodiafiltration device

An apparatus for hemodiafiltration that maintains the blood concentration of the patient relatively constant. A pump is connected to a branch off the external flow path of the dialysator which pumps fluid to the circulation system of the patient to compensate for the patient's fluid loss through the hemodiafilter membrane. A suction pump which affects the transmembrane pressure across the hemodiafilter membrane is controlled to achieve the desired filtrate flow necessary to balance the return flow to the patient.

СПОСОБ И УСТРОЙСТВО ДЛЯ ОБЕСПЕЧЕНИЯ СТЕРИЛЬНОСТИ ДЛЯ СИСТЕМ ВЛИВАНИЯ ЖИДКОСТИ

Изобретение относится к медицине и предназначено для обеспечения подачи стерильной жидкости. Раскрыты способ и устройство для предотвращения образования обратного потока жидкости, например, такого как продуктов крови, в источник стерильной замещающей жидкости. Устройство содержит регулируемый пережимной клапан, который расположен в части трубопровода, по которой подают стерильную замещающую жидкость во внешнюю систему. В одном из примеров реализации управление клапаном производится посредством блока управления, на основе давлений жидкости выше и ниже клапана, полученных соответственно датчиком давления, расположенным выше по течению потока, и датчиком давления, расположенным ниже по течению потока. Клапан предпочтительно открыт только когда давление выше по течению потока превышает давление ниже по течению потока. Это обеспечивает протекание замещающей жидкости только в одном направлении, когда пережимной клапан полностью перекрывает трубопровод, находясь в закрытом положении. Благодаря ...

Verfahren zum Ermitteln wenigstens einer Kennzahl den Glukosestoffwechsel eines Patienten betreffend und Vorrichtung hierfür

Vorrichtung zum Ermitteln wenigstens einer Kennzahl den Glukosestoffwechsel eines Patienten (3) betreffend während einer extrakorporalen Dialysebehandlung des Patienten (3) mittels einer Dialysevorrichtung, welche eine Dialysatseite (7) und/oder eine Substituatseite (17a, 17v) aufweist, wobei die Kennzahl aus der Blutglukosekonzentration oder der Insulinkonzentration über der Zeit berechnet wird, mit einer Einrichtung zum Messen einer Konzentration wenigstens eines Stoffs aus einer Gruppe von Stoffen, welche aus Glukose und Insulin besteht,gekennzeichnet durcheine Einrichtung, welche geeignet und vorgesehen ist zum extrakorporalen Zugeben wenigstens eines Stoffs aus der Gruppe von Stoffen, welche aus Glukose und Insulin besteht, auf der Dialysatseite (7) und/oder auf der Substituatseite (17a, 17v) zum Zwecke der Untersuchung des Glukosestoffwechsels zum Überprüfen auf Vorliegen einer pathologischen Glukosetoleranz.

Extrakorporaler Fluidkreislauf

EINRICHTUNG ZUR FILTRATION VON PLASMA AUS BLUT.

Modular home dialysis system

A method is described for priming a dialyzer placed in an extracorporeal circuit of a nemodialysis machine in situ. The method comprises the steps of substantially filling the extracorporeal circuit and the blood side of the dialyzer with fluid (such as dialysate, RO water, saline, etc.), and inducing pressure pulses in the fluid. The pressure pulses cause air bubbles from the blood side of the dialyzer to be sheared off the dialyzer membrane. The air bubbles are then conducted from the dialyzer and removed from the extracorporeal circuit. Backfiltering of fluid across the dialyzer from the dialysate circuit into the extracorporeal circuit is performed in synchrony with the pressure pulses to assist in the shearing off of air bubbles from the blood side of the dialyser membrane.

ART KIDNEY

HEMODIALYSESYSTEM

DIALYSEGER�T WITH UNABH�NGIGER CONTROL OF AT LEAST TWO IONI SUBSTANCES IN A K�RPER PATIENT

BLOOD CLEANING DEVICE

DIALYSIS MACHINE

TWO-STAGE DIA. FILTRATION ARRANGEMENT

INFUSION EQUIPMENT

PROCEDURE AS A CHECK OF THE SODIUM CONCENTRATION OF A DIALYSATS AFTER REGULATION

DIALYSIS MACHINE

DIALYSIS APPARATUS

Extracorporeal blood purification device

Hemodiafiltration / hemofiltration cartridges

Hemofiltration system

Dialysis device

The invention relates to a dialysis device (1) comprising a dialysate circuit, which contains a first dialyzer (3) and a second dialyzer (5), wherein the first dialyzer (3) can be connected to a blood circuit of a patient by means of a blood feed (11) and a return (13), a drain for a retentate flow (Q ...

An apparatus for extracorporeal blood treatment

An apparatus for extracorporeal blood treatment, comprising a treatment unit (2) having a first chamber (3) and a second chamber (4) separated from one another by a semipermeable membrane (5), a blood removal line (6) connected in inlet with the first chamber (3) and a blood return line (7) connected in outlet with the first chamber; an infusion line (9;9a, 9b) of a replacement fluid and a fluid evacuation line (10) connected in outlet from the second chamber. A regulating device (20) of a transmembrane pressure is active on at least one of the lines and a control unit (15) is configured to: command the regulating device (20) by setting a first increase (STMP ...

Method and apparatus for controlling a fluid flow rate in a fluid transport line of a medical device

An apparatus for controlling a fluid flow rate in a fluid transport line (12, 15, 16) of a medical device, comprising at least a first pump, at least a first chamber (29, 29a) for collecting the fluid, at least a sensor for providing a first value (v1) correlated to the amount of fluid in the first chamber (29, 29a), and a control device (21, 21 a) configured for receiving a second value representative of the fluid flow rate through the first pump (18, 18a) and for correlating the second value with the first value (v1 ) in order to obtain an accuracy check of the second value. A method for controlling a fluid flow rate in a fluid transport line (12, 15, 16) of a medical device is also disclosed, comprising the steps of pumping a fluid, collecting the fluid in a first chamber (29, 29a), sensing a first value (v1) correlated to the amount of fluid in the first chamber (29, 29a), and detecting and sending a second value representative of the fluid flow rate through the first pump (18, 18a) ...

Extracorporeal blood treatment apparatus and method of setting an extracorporeal blood treatment

It is described an extracorporeal blood treatment apparatus (1) with a user interface (12) device capable configuring and allowing execution of one or more isolated ultrafiltration tasks during the course of a dialysis treatment. The extracorporeal blood treatment apparatus (1) is controlled in a normal mode, where dialysis fluid is fed to the blood treatment unit (2), and in an isolated ultrafiltration mode, where fresh dialysis fluid is no longer fed to the blood treatment unit (2).

METHOD AND APPARATUS FOR A HEMODIAFILTRATION DELIVERY MODULE

This invention provides a method and apparatus for a hemodiafiltration delivery module (100) that is used in conjunction with a UF controlled dialysis machine to enable hemodiafiltration therapy to be performed. Apparatus includes a dialysis machine and an extracorporeal circuit in communication with a diafiltration module including a first conduit (120) for receiving from and discharging fluid to dialysis machine and a second conduit (64) to selectively receive a diverted fluid and including at least one sterilizing filter (92) for filtering the diverted fluid to produce substitution fluid which is delivered to the extracorporeal circuit and a control unit (110) responsive to characteristics of fluid or blood to prevent flow of the substitution fluid to the extracorporeal circuit when at least one of the characteristics meets a prescribed criteria.

SELECTIVE PLASMA EXCHANGE THERAPY

Disclosed is a method for removing from a patient's blood a specific plasma fraction containing substances within a specific molecular weight range and a plasma purification apparatus by which the method can be accomplished.

IONIC ENHANCED DIALYSIS/DIAFILTRATION SYSTEM

A dual-stage filtration system and methods for using the same include first and second filtration cartridges (122, 138) particularly suited for hemodiafiltration and/or hemodialysis. As fluid enters the first filtration cartridge (122), the hydrogen ion concentration (pH) is reduced by exposing it to an acidic solution such as citric acid across a filter membrane (124). This stage allows for improved removal of certain toxins in the fluid, such as protein-bound substances that disassociate more readily from proteins at a lower pH. As the filtered fluid enters the second filtration cartridge (138), the pH of the fluid is restored to normal levels prior to infusion to a patient. ...

AUTOMATIC REINFUSING SYSTEM

TOTAL FLUID LOSS CONTROL SYSTEM

A system or method controls total fluid loss (TFL) in a patient undergoin g hcmofiltration therapy administered through an extracorporeal circuit by f requently calculating and storing a retrievable value representing TFL. At s ession start or restart, the value is read to determine whether TFL is out o f tolerance, and if so, fluid balance is restored before administering a pre scribed therapy. The TFL value is calculated during therapy by measuring flu id added to the circuit and fluid removed from the circuit, and the result i s stored as an updated value. Jf TFL drifts out of tolerance fluid flow rate s may be temporarily changed until a desired fluid balance is restored. The system may include a microprocessor based advanced controller receiving the fluid measurements as feedback for regulating substitution fluid and filtrat e flow rates, and updating the TFL value in non-volatile memory.

Dialysis device

The invention relates to a dialysis device ( 1 ) having a dialysate circuit comprising a first dialyzer ( 3 ) and a second dialyzer ( 5 ) wherein the first dialyzer ( 3 ) is connectable to a blood circulation of a patient via a blood feed line ( 11 ) and a recirculation ( 13 ), an effluent for a retentate flow (Q effluent ) from the dialysate circuit to the second dialyzer ( 5 ) is provided and a permetate stream (Q out ) of the second dialyzer ( 5 ) in the dialysate circuit is passed to the first dialyzer ( 3 ), the second dialyzer ( 5 ) comprising a filter membrane having a cut-off value of at least 500 Da and the first dialyzer ( 3 ) comprising a filter membrane having a cut-off value exceeding that of the second dialyzer ( 5 ).

Infusion pump flow balancing and synchronization system

A renal failure therapy system includes a blood pump, a dialysis fluid pump, a filtrate pump, at least one infusion pump, and a control unit configured to synchronize operation of the infusion pump to the blood pump or the filtrate pump.

Method for regulating the supply of substituting during extracorporeal blood treatment and extracorporeal blood treatment device comprising a unit for regulating the supply of substituate

The present invention relates to a method for regulating supply of substituate in an extracorporeal blood treatment with an extracorporeal blood treatment apparatus comprising a dialyzer divided by a semipermeable membrane into a blood chamber and a dialyzing fluid chamber and a device for supplying substituate. Moreover, the present invention relates to an extracorporeal blood treatment apparatus having a device for regulating supply of substituate. Regulation of supply of substituate in the extracorporeal blood treatment takes place as a function of the rheological loading of the dialyzer. To regulate supply of substituate during extracorporeal blood treatment, rheological loading of the dialyzer is determined from transmembrane pressure on the dialyzer and flow resistance of the dialyzer and substituate rate is increased or reduced according to the loading. The selection of dialyzer parameters or blood parameters is therefore no longer necessary and the distinction between pre-dilution and post-dilution is also made obsolete.

Method for removing blood from an extracorporeal blood circuit as well as apparatuses

The present invention relates to a method for removing blood from an extracorporeal blood circuit and/or a functional device, each connectable or connected with a blood treatment apparatus for the purpose of blood treatment of a patient. The blood treatment apparatus of the method comprises or is connected with at least one extracorporeal blood circuit with a line having interior portions, the extracorporeal blood circuit comprising at least one arterial line section and at least one venous line section, wherein a first section of the arterial line section is configured to be connected with a second section of the venous line section, and further comprises at least one blood pump for conveying blood within the line interior portions. The method includes the step of operating the blood pump in a second conveying direction which is opposite to a first customary conveying direction. It further relates to corresponding apparatuses.

Apparatus for extra-corporeal blood treatment and method of presetting an initial mode of treatment for an extra-corporeal blood treatment apparatus

An apparatus for extra-corporeal blood treatment and a method of presetting an initial mode of treatment in the opening phase of an extra-corporeal blood treatment are controlled based on the opening phase of a haemodiafiltration, in which particularly fast removal of electrolytes such as potassium or of urea occurs. The apparatus has a control and computing unit for presetting an initial mode of treatment, in which over a preset interval of time, substituate is fed to the extra-corporeal blood circuit, dialysis fluid is not fed through the dialyser and instead only ultrafiltrate is withdrawn from the dialyser and, on expiry of the preset interval of time, dialysis fluid is fed through the dialyser. Alternatively, dialysis fluid is provided during the preset interval of time through the dialyser at a dialysis fluid flow rate that is smaller than the dialysis fluid flow rate after the preset interval of time has elapsed.

Priming System and Method for Dialysis Systems

The application is directed to an extracorporeal blood processing system capable of using dialysate to prime the system. A plastic molded compact manifold supports molded blood and dialysate fluidic pathways along with relevant sensors, valves and pumps. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine. A two-way valve in the manifold is used to direct the dialysate flow through the blood circuit to prime the circuit for use in treatment. 1. A priming process for priming a manifold within a dialysis machine for use in a dialysis treatment , comprising the steps of:a. Inserting said manifold into the dialysis machine, wherein said manifold comprises a substrate defining a first circuit and a second circuit and a compressible valve structure in fluid communication with each of said first and second circuits, wherein said valve structure has a first state and a second state and wherein, when in said first state, fluid from the first circuit cannot enter into the second circuit and when in said second state, fluid from the first circuit can enter into the second circuit;b. Placing said valve in said second state by removing pressure from said compressible valve structure;c. Pumping fluid through said first and second circuits;d. Placing said valve in said first state by applying pressure to said compressible valve structure; ande. Removing fluid from said second circuit.2. The priming process of wherein the first circuit is a dialysate circuit and wherein the second circuit is a blood circuit.3. The priming process of wherein the fluid is dialysate and wherein claim 2 , in said second state claim 2 , the dialysate flows through the dialysate circuit and into the blood circuit.4. The priming process of wherein the dialysate is removed from the blood circuit upon completion of the priming process.5. The priming process of wherein the dialysate is pumped from a dialysate reservoir and not from a separate ...

PERFORMANCE MONITORING OF REGIONAL CITRATE ANTICOAGULATION

A monitoring device operates to monitor regional citrate anticoagulation (RCA) in a blood treatment system which is configured to administrate citrate to an extracorporeal blood circuit () upstream of a dialyzer () during a treatment session. At consecutive time steps during the treatment session, the monitoring device obtains a current measurement value of systemic ionized calcium (iCa) or systemic total calcium (Ca), operates a predefined algorithm on the current measurement value to generate a current computation value that represents ionized calcium (iCa, iCa) in blood at a selected location (loc2, loc3) downstream or upstream of the dialyzer () in the extracorporeal blood circuit (), and presents and/or evaluates the current computation value for assessment of the regional citrate anticoagulation. The need for conventional blood sampling and blood analysis upstream and/or downstream of the dialyzer, e.g. during CRRT, is thereby reduced significantly. 127-. (canceled)28: A monitoring device for a blood treatment system , the blood treatment system comprising an extracorporeal blood circuit which comprises a blood withdrawal line and a blood return line for connection to a vascular system of a subject and a dialyzer intermediate the blood withdrawal and blood return lines , wherein the blood treatment system is configured for regional citrate anticoagulation by administration of citrate to the extracorporeal blood circuit upstream of the dialyzer during a treatment session , said monitoring device comprising:a memory; and obtain a current measurement value of systemic ionized calcium or systemic total calcium,', 'operate a predefined algorithm on the current measurement value to generate a current computation value that represents ionized calcium in blood at a selected location downstream or upstream of the dialyzer in the extracorporeal blood circuit, and', 'display, via a display device, the current computation value, and/or determine an assessment of the ...

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

An extracorporeal blood treatment apparatus is provided comprising a filtration unit connected to a blood circuit and to a dialysate circuit, a preparation device for preparing and regulating the composition of the dialysis fluid; a control unit is configured for receiving a desired sodium mass transport at the end of the treatment session and for setting the sodium concentration value for the dialysis fluid in the dialysis supply line at a set point to achieve the desired sodium mass transport at the end of the treatment session. 1. An apparatus for extracorporeal blood treatment comprising:a filtration unit including a primary chamber and a secondary chamber separated by a semi-permeable membrane;a blood withdrawal line connected to an inlet of the primary chamber;a blood return line connected to an outlet of the primary chamber, said blood withdrawal line and blood return line being configured for connection to a patient cardiovascular system;a dialysis supply line;a dialysis effluent line connected to an outlet of the secondary chamber;a preparation device for preparing a dialysis fluid connected to said supply line and including a regulator for regulating the composition of the dialysis fluid; anda control unit connected to the regulator and programmed to receive a desired mass transport of a substance at the end of a treatment session and a value representative of a first parameter, wherein the desired mass transport is a set amount of the substance that is transported over the semi-permeable membrane of the filtration unit during the treatment session, the first parameter being chosen from the group consisting of a plasma conductivity, a plasma conductivity-related parameter, a concentration of the substance in the blood, a concentration-related parameter of the substance in the blood, a conductivity of the dialysis fluid, a conductivity-related parameter of the dialysis fluid, a concentration of the substance in the dialysis fluid, and a concentration- ...

DIALYSIS SYSTEM HAVING INDUCTIVE HEATING

A dialysis fluid system includes a dialysis fluid inlet; a dialysis fluid outlet; a pump positioned and arranged to pump dialysis fluid through the dialysis fluid inlet and the dialysis fluid outlet; and an inductive heater located between the dialysis fluid inlet and the dialysis fluid outlet, the inductive heater including a fluid flowpath positioned and arranged to receive non-heated dialysis fluid from the dialysis fluid inlet and to output heated dialysis fluid to the a dialysis fluid outlet, a conductive heater element located within the fluid flowpath so as to be or act as a secondary coil of a transformer, and a primary coil of the transformer located outside of the fluid flowpath and positioned so as to magnetically induce a current into the conductive heater element, causing the conductive heater element and surrounding fluid to heat. 1. A dialysis fluid system comprising:a dialysis fluid inlet;a dialysis fluid outlet;a pump positioned and arranged to pump dialysis fluid through the dialysis fluid inlet and the dialysis fluid outlet; and a fluid flowpath positioned and arranged to receive non-heated dialysis fluid from the dialysis fluid inlet and to output heated dialysis fluid to the dialysis fluid outlet,', 'a conductive heater element located within the fluid flowpath so as to be or act as a secondary coil of a transformer, and', 'a primary coil of the transformer located outside of the fluid flowpath and positioned so as to magnetically induce a current into the conductive heater element, causing the conductive heater element and surrounding dialysis fluid to heat., 'an inductive heater located between the dialysis fluid inlet and the dialysis fluid outlet, the inductive heater including'}2. The dialysis fluid system of claim 1 , wherein the fluid flowpath and the conductive heater element are located within a heater housing in fluid communication with the dialysis fluid inlet and the dialysis fluid outlet.3. The dialysis fluid system of claim 2 , ...

INFUSION SITE FOR IMPROVED MIXING OF FLUIDS

The present disclosure relates to a blood line () comprising an infusion site () intended to inject into the line a solution comprising: —a first main channel () having a first passage section, —a second main channel () having a second passage section, —means for the formation () of a turbulence area located downstream from the first main channel, located upstream from the second main channel, these formation means comprising a first fluid passage means () defining a reduction () in the passage section and whose smallest passage section is smaller than the first passage section and smaller than the second fluid passage section, —a secondary channel () comprising an inlet () for letting in the solution and an outlet () in fluid communication with the first main channel or the means for the formation of a turbulence area or the second main channel. 1. An extracorporeal circulation blood or plasma treatment device with local anticoagulation including:a filter having a first compartment and a second compartment separated by a semipermeable membrane;an arterial line in fluid communication with the first compartment of the filter;a pre-infusion channel for a local anticoagulation substance in fluid communication with the arterial line;a container of a local anticoagulation substance in fluid communication with the pre-infusion channel; a first line portion in fluid communication with an outlet of the filter,', "a second line portion in fluid communication with a patient's vascular access,", a first main channel in fluid communication with the first line portion and having a first passage section,', 'a second main channel in fluid communication with the second line portion and having a second passage section, and', 'a turbulence area downstream from and in fluid communication with the first main channel, and upstream from and in fluid communication with the second main channel, the turbulence area comprising a first fluid passage defining a reduction in passage section ...

APPARATUS FOR CARRYING OUT AN EXTRACORPOREAL BLOOD TREATMENT AND METHOD FOR ADDING A SUBSTITUTION FLUID

The invention relates to an apparatus for carrying out an extracorporeal blood treatment in which a substitution fluid is administered to the patient, wherein the apparatus comprises an extracorporeal blood circuit and a substitution line opening into the extracorporeal blood circuit, wherein the substitution line has a pump for conveying substitution fluid into the extracorporeal circuit, wherein at least two, and preferably more than two, containers for the provision of a substitution fluid are connected separately and at the intake side of the pump to the substitution line, and wherein at least one pressure valve is arranged between the pump and at least one of the containers, said pressure valve allowing a flow of substitution fluid to the pump on an exceeding of an opening pressure. 1119119211232119. An apparatus for carrying out an extracorporeal blood treatment in which a substitution fluid is administered to the patient , wherein the apparatus comprises an extracorporeal blood circuit () and a substitution line () opening into the extracorporeal blood circuit () , wherein the substitution line () has a pump () for conveying substitution fluid into the extracorporeal blood circuit () , and wherein at least two , and preferably more than two , containers () for providing a substitution fluid are connected separately and at the intake side of the pump () to the substitution line () , characterized in that{'b': 26', '21', '23', '21, 'at least one pressure valve () is arranged between the pump () and at least one of the containers (), said pressure valve allowing a flow of substitution fluid to the pump () on an exceeding of an opening pressure.'}226232123. An apparatus in accordance with claim 1 , characterized in that the arrangement of the pressure valves () and containers () is such that a staggering of the opening pressures is achieved which have to be exerted by the pump () to obtain substitution fluid from different containers ().326252319. An apparatus in ...

Dialysis system including automatic priming

A hemodialysis system comprising: a source of priming fluid; an extracorporeal circuit including an arterial line, a venous line, and a drip chamber; a level sensor operable with the drip chamber; a reversible blood pump operable with the extracorporeal circuit; a connection between the arterial and the venous line; and a priming sequence in which priming fluid from the source is pumped in a reverse pump direction through the extracorporeal circuit and reversibly in a normal pump direction through the extracorporeal circuit, wherein an output from the level sensor is used to determine when to stop pumping in at least one of the directions.

METHOD FOR REMOVING FLUID FROM A BLOOD FILTER AFTER COMPLETING A BLOOD TREATMENT SESSION BY MEANS OF FLOW INCREASE AND TREATMENT DEVICE FOR CARRYING OUT SAID METHOD

The present invention relates to a method for removing a first fluid from a blood filter for the blood treatment of a patient and/or for removing blood from the blood filter after completing the blood treatment session. It further relates to a medical treatment apparatus having a control device with which a method for removing a first fluid from a blood filter is executable, a digital storage medium, and a computer program product. 115-. (canceled)16. A medical treatment apparatus comprising:at least one extracorporeal blood circuit with a line interior;at least one blood pump which is arranged at or in the extracorporeal blood circuit for conveying blood within the line interior of the extracorporeal blood circuit;at least one device for introducing a second fluid into the arterial blood line; anda control device configured to control the medical blood treatment apparatus to cause fluid to be displaced from the blood chamber by introducing a second fluid into the arterial blood line.17. The medical treatment apparatus according to claim 16 , wherein the control device is further configured to control a medical blood treatment apparatus to cause a subsequent displacing of a first fluid from the blood chamber by an introduced substituate with a predetermined substituate flow rate through the blood filter between 135 ml/min and 165 ml/min.18. The medical treatment apparatus according to claim 17 , wherein the subsequent displacing of the first fluid from the blood chamber by an introduced substituate with the predetermined substituate flow rate through the blood filter is between 135 ml/min and 165 ml/min in average.19. The medical treatment apparatus according to claim 16 , wherein the control device is further configured to control a medical blood treatment apparatus to perform a blood treatment.20. The medical blood treatment apparatus according to comprising a buffer tank for receiving fluid which has been displaced from the blood chamber claim 16 , wherein the ...

APPARATUS AND A METHOD FOR EXTRACORPOREAL BLOOD TREATMENT

An apparatus for extracorporeal blood treatment comprises a sensor () for emitting a signal indicating a variation in blood volume (ΔBv″) of an individual () subjected to extracorporeal blood treatment and a sensor () for emitting a signal indicating a weight loss of the individual. A control unit () receives the signals, compares the ratio between the relative variation of blood volume (ΔBv/BV) and the relative variation of weight loss (AWL/TW) of the individual with a desired value, and controls the weight loss of the individual on the basis of the comparison. The apparatus enables automatically controlling a dialysis, preventing some complications due to hypotension. 1. (canceled)228-. (canceled)30. The method of claim 29 , wherein controlling the weight loss system comprises controlling a weight loss rate for the individual (WLR) as a function (II) of the desired value of the refilling index (IR) and the calculated value of the refilling index (IR):{'br': None, 'i': WLR', '=f', 'IR', ';IR, 'sub': i', 'DES', 'CAL, '()\u2003\u2003(II)'}32. The method of claim 29 , comprising verifying whether a relative blood volume variation and a relative weight loss variation of the individual is in a predetermined relation with the desired value of the refilling index (IR) and controlling the weight loss system on the basis of the verification claim 29 , the relative blood volume variation being a ratio between the blood volume variation (ΔBV) and the total blood volume of the individual (BV) claim 29 , the relative weight loss variation being a ratio between the weight loss variation (ΔWL) and the total weight (TW) of the individual or the body water weight (BWW) of the individual.33. The method of claim 29 , comprising verifying whether a ratio between a percentage relative blood volume variation and a percentage relative weight loss variation of the individual is in a predetermined ratio with a desired value and controlling the weight loss system on the basis of the ...

BLOOD CONDITION MONITOR, BLOOD CONDITION MONITORING METHOD, BLOOD CONDITION MONITORING SYSTEM, AND BLOOD CONDITION IMPROVING PROGRAM

Provided is a blood condition monitor using a permittivity-based coagulation measurement technology to monitor the condition of blood during extracorporeal circulation and thus being useful for avoiding blood problems from occurring during extracorporeal circulation. Provided is a blood condition monitor including: an extracorporeal circulation unit for extracorporeally circulating blood; and a first blood measurement unit for measuring an electrical characteristic of the blood obtained by applying an AC electric field to the blood. The first blood measurement unit is disposed in the blood circuit of the extracorporeal circulation unit. The blood condition monitor further includes a blood condition analysis unit for analyzing a change in blood condition on the basis of data on temporal changes in the electrical characteristic. 1. A blood condition monitor comprising:an extracorporeal circulation unit for extracorporeally circulating blood; anda first blood measurement unit for measuring an electrical characteristic of the blood obtained by applying an AC electric field to the blood.2. The blood condition monitor according to claim 1 , wherein the first blood measurement unit is disposed in a blood circuit of the extracorporeal circulation unit.3. The blood condition monitor according to claim 1 , further comprising a blood condition analysis unit for analyzing a change in blood condition on the basis of data on temporal changes in the electrical characteristic.4. The blood condition monitor according to claim 1 , further comprising a second blood measurement unit.5. The blood condition monitor according to claim 4 , further comprising a third blood measurement unit.6. The blood condition monitor according to claim 5 , further comprising a display unit for displaying at least one result selected from a result of measurement by the first blood measurement unit claim 5 , a result of analysis based on data obtained from the first blood measurement unit claim 5 , a ...

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. 1. A medical treatment system , comprising:a flow balancing fluid management element configured to pump fluid from a patient interface device during a treatment and configured to pump fluid into the patient interface device during the treatment, the flow balancing fluid management element including a synchronization mechanism that is configured to proportion flow to and from the patient interface device in a predefined ratio during the treatment;the patient interface device being a device that interfaces with a patient fluid compartment including at least one of a dialyzer, a hemofilter, a hemodiafilter, an ultrafilter, and a plasmapheresis device;a proportioning bypass channel that includes a proportioning bypass pump and configured to pump fluid to or from the patient interface device in a predefined amount that has a predefined relationship to flows in said flow balancing fluid management element so as to produce a predefined net withdrawal from, or infusion into, a patient;a controller configured to control at least the proportioning bypass pump and including a processor programmed to regulate a rate of flow through the proportioning bypass pump to achieve the predefined net withdrawal from, or infusion into, the patient; andan infusion circuit connectable to a source of fluid and including an infusion circuit pump and connected to one or both of blood lines connected to a patient access, whereinat least a portion of the infusion circuit is selectively connectable to the proportioning bypass channel such that the ...

Dialysis systems including therapy prescription entries

A dialysis system includes a dialysis machine configured to control fluid loss or ultrafiltration (“UF”) volume over a treatment; a graphical user interface (“GUI”) that allows selection of a prescription entry for the treatment; and a processor operating with the GUI, the processor programmed to (i) receive a plurality of prescription entries via a local or wide area mode of data communication, each prescription entry including at least one prescribed parameter for operating the dialysis machine to control the fluid loss or UF volume, and (ii) enable an operator to choose between the prescription entries provided at the GUI, and select one of the prescription entries for the treatment.

Hemodialysis system including a disposable cassette

A dialysis system includes a dialyzer, a sorbent cartridge configured to clean used dialysate from the dialyzer, a dialysate pump actuator configured to pump dialysate to the dialyzer, and a conductivity sensor located adjacent to a temperature sensor. The dialysis system also includes a disposable cassette configured to carry dialysate pumped by the dialysate pump actuator. The disposable cassette includes a combined conductivity and temperature sensor fluid chamber separate from the conductivity sensor and the temperature sensor and located so as to operate with the conductivity sensor and the temperature sensor, respectively, when mounted for operation.

BLOOD TREATMENT DEVICE WITH AUTOMATIC REDUCTION OF A SUBSTITUTION-SOLUTION FLOW RATE

The disclosure relates to a blood treatment device for use in blood treatment therapies, comprising: an extracorporeal blood circuit, a dialyzer and a dialysis fluid circuit, wherein the extracorporeal blood circuit and the dialysis fluid circuit are separated from each other via a membrane provided in the dialyzer, via which blood can be filtered; at least one substitution solution pump, which is configured to supply a substitution solution to the extracorporeal blood circuit before and/or after the dialyzer; an effluent pressure sensor, which is configured to measure a pressure in the dialysis fluid circuit after the dialyzer, and a control unit, which is configured to automatically reduce a flow rate of the at least one substitution solution pump when an effluent pressure measured by the effluent pressure sensor drops during an ongoing blood treatment therapy. 1. A blood treatment device for use in blood treatment therapies , the blood treatment device comprising:an extracorporeal blood circuit, a dialyzer and a dialysis fluid circuit, the extracorporeal blood circuit and the dialysis fluid circuit separated from each other via a membrane provided in the dialyzer, via which blood can be filtered;at least one substitution solution pump, which is configured to supply a substitution solution to the extracorporeal blood circuit before and/or after the dialyzer;an effluent pressure sensor configured to measure pressure in the dialysis fluid circuit after the dialyzer; anda control unit configured to automatically reduce a flow rate of the at least one substitution solution pump when an effluent pressure measured by the effluent pressure sensor drops during an ongoing blood treatment therapy.2. The blood treatment device according to claim 1 , wherein the control unit is configured to determine that clogging of the dialyzer or blood clotting is present solely on the basis of the effluent pressure measured by the effluent pressure sensor dropping during the ongoing ...

SYSTEM FOR PERITONEAL DIALYSIS AND EXTRACORPOREAL BLOOD TREATMENTS

A dialysis system is configured to enable a patient to undergo both peritoneal dialysis and extracorporeal blood treatments. The example dialysis system includes a base unit configurable to provide a first fluid for use in preforming at least one peritoneal dialysis treatment at a first time. The base unit is further configurable to provide a second, different fluid for use in at least one extracorporeal blood treatment at a second, different time. The example dialysis system also includes a blood treatment unit configured to be docked to the base unit. The blood treatment unit includes a blood pump configured to pump blood from the patient to a blood filter and from the blood filter back to the patient. The blood filter or a blood line in communication with the blood filter receives the second fluid from the base unit for use in the at least one extracorporeal blood treatment. 1. : In a system enabling both peritoneal dialysis and extracorporeal blood treatments , the system comprising:a base unit configured to provide first fluid for use in performing at least one peritoneal dialysis treatment on the patient; and a blood pump configured to pump blood from the patient and back to the patient,', 'a controller for controlling the blood pump, and', 'a user interface for displaying at least one of blood pump settings or blood parameter readings,, 'a blood treatment unit operable with the base unit to perform at least one extracorporeal blood treatment on a patient, the blood treatment unit including'}wherein the base unit is configured to provide a second, different fluid for use in the at least one extracorporeal blood treatment.2. : The system of claim 1 , wherein the first fluid is a peritoneal dialysis dialysate and the second fluid is an extracorporeal blood treatment dialysate.3. : The system of claim 1 , wherein the second fluid is a replacement fluid.4. : The system of claim 1 , wherein the base unit is configured to prepare dialysis fluid for the at least one ...

DIALYSIS DEVICE HAVING MEANS FOR RECOGNIZING A SHUNT RECIRCULATION

The invention relates to dialysis device having an extracorporeal blood circuit which has an arterial line having a blood pump and an arterial needle for connection to a patient, a venous line having a venous needle for connection to a patient and a dialyzer arranged between the arterial line and the venous line and having a blood chamber and a dialysis fluid chamber, wherein the dialysis device furthermore has a control unit, wherein the dialysis device furthermore has an extracorporeal blood pressure sensor which is arranged at the suction side of the blood pump and wherein the control unit is configured such that a signal output takes place which indicates the presence of recirculation when a change in the signal of the sensor following a trigger event exceeds a threshold value. 1. A dialysis device having an extracorporeal blood circuit which has an arterial line having a blood pump and an arterial needle for connection to a patient , a venous line having a venous needle for connection to a patient and a dialyzer arranged between the arterial line and the venous line and having a blood chamber and a dialysis fluid chamber , wherein the dialysis device furthermore has a control unit , characterized in thatthe dialysis device furthermore has an extracorporeal blood pressure sensor which is arranged at the suction side of the blood pump and that the control unit is configured such that a signal output takes place which indicates the presence of recirculation when a change in the signal of the sensor following a trigger event exceeds a threshold value.2. A dialysis device in accordance with claim 1 , characterized in that the trigger event is a temporary thickening or thinning of the blood conducted in the extracorporeal blood circuit at the pressure side of the blood pump.3. A dialysis device in accordance with claim 1 , characterized in that it furthermore has a dilution system having a dilution line opening into the extracorporeal blood circuit and having a ...

Hybrid blood and peritoneal dialysis treatment systems and methods

A method for a hybrid blood and peritoneal dialysis (“PD”) machine comprising: (i) determining whether a previous treatment left a last fill of dialysate in a patient's peritoneum; (ii) if a next treatment is a PD treatment, and if the previous treatment did not leave the last fill of dialysate, causing a PD treatment in which a first cycle is a fill cycle to be initiated; (iii) if the next treatment is a PD treatment, and if the previous treatment did leave the last fill of dialysate, causing a PD treatment in which a first cycle is a last fill drain cycle to be initiated; and (iv) if the next treatment is a blood treatment and if the previous treatment did leave the last fill of dialysate, causing a blood treatment including a last fill drain cycle to be initiated.

Method and apparatus to verify correct replacement fluid in a therapeutic exchange procedure

A method and apparatus are provided for automatically detecting the type of replacement fluid loaded by the operator during a therapeutic exchange procedure and to provide a warning alarm if an incorrect fluid is used. After the operator connects the container of replacement fluid to the replacement fluid line of a single-use kit and enters into the controller an identification of the exchange procedure to be performed, the replacement fluid is flowed through a segment of the kit in proximity to a sensor associated with the hardware component that detects the type of fluid flowing through the segment. The controller verifies whether the replacement fluid detected in the segment corresponds to that appropriate for the selected exchange procedure, and notifies the operator in the event that an incorrect replacement fluid has been loaded.

Priming System and Method for Dialysis Systems

The application is directed to an extracorporeal blood processing system capable of using dialysate to prime the system. A plastic molded compact manifold supports molded blood and dialysate fluidic pathways along with relevant sensors, valves and pumps. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine. A two-way valve in the manifold is used to direct the dialysate flow through the blood circuit to prime the circuit for use in treatment. 1. A priming process for priming a manifold within a dialysis machine for use in a dialysis treatment , comprising the steps of:a. Inserting said manifold into the dialysis machine, wherein said manifold comprises a substrate defining a first circuit and a second circuit and a compressible valve structure in fluid communication with each of said first and second circuits, wherein said valve structure has a first state and a second state and wherein, when in said first state, fluid from the first circuit cannot enter into the second circuit and when in said second state, fluid from the first circuit can enter into the second circuit;b. Placing said valve in said second state by removing pressure from said compressible valve structure;c. Pumping fluid through said first and second circuits;d. Placing said valve in said first state by applying pressure to said compressible valve structure; ande. Removing fluid from said second circuit.2. The priming process of wherein the first circuit is a dialysate circuit and wherein the second circuit is a blood circuit.3. The priming process of wherein the fluid is dialysate and wherein claim 2 , in said second state claim 2 , the dialysate flows through the dialysate circuit and into the blood circuit.4. The priming process of wherein the dialysate is removed from the blood circuit upon completion of the priming process.5. The priming process of wherein the dialysate is pumped from a dialysate reservoir and not from a separate ...

METHOD FOR REGULATING THE SUPPLY OF SUBSTITUATE DURING EXTRACORPOREAL BLOOD TREATMENT AND EXTRACORPOREAL BLOOD TREATMENT DEVICE COMPRISING A UNIT FOR REGULATING THE SUPPLY OF SUBSTITUATE

A method that regulates supply of substituate in an extracorporeal blood treatment with an extracorporeal blood treatment apparatus comprising a dialyzer divided by a semipermeable membrane into a blood chamber and a dialyzing fluid chamber and a device for supplying substituate. An extracorporeal blood treatment apparatus that includes a device for regulating supply of substituate. Regulation of supply of substituate in the extracorporeal blood treatment takes place as a function of the rheological loading of the dialyzer. To regulate supply of substituate during extracorporeal blood treatment, rheological loading of the dialyzer is determined from transmembrane pressure on the dialyzer and flow resistance of the dialyzer and substituate rate is increased or reduced according to the loading. The selection of dialyzer parameters or blood parameters is therefore no longer necessary and the distinction between pre-dilution and post-dilution is also made obsolete. 1. An apparatus for hemodiafiltration , comprising:an extracorporeal blood circuit comprising a blood pump;a dialyzing fluid system;a dialyzer divided by a semipermeable membrane into a blood chamber and a dialyzing fluid chamber, the blood chamber being part of the extracorporeal blood circuit, the dialyzing fluid chamber being part of the dialyzing fluid system, and the semipermeable membrane comprises dialyzer fibers;a sensor system configured for measuring transmembrane pressure (TMP) to determine a measured TMP value, and configured for measuring longitudinal flow resistance along the dialyzer fibers to determine a measured flow resistance value;a substituate dose rate controller configured to increase or decrease a rate of dosing substituate to the extracorporeal blood circuit; anda control unit in communication with the sensor system and the substituate dose rate controller, the control unit being configured to (a) determine an adjustment to a rate of dosing substituate into the extracorporeal blood ...

INFUSION SITE FOR IMPROVED MIXING OF FLUIDS

The invention relates to a blood line () comprising an infusion site () intended to inject into the line a solution, comprising: 134-. (canceled)35. A blood line for extracorporeal blood or plasma treatment comprising:a first line portion intended to be connected to an outlet of a filter, the first line portion having a first line passage section,a second line portion intended to be connected to a patient's vascular access, the second line portion having a second line passage section,a post-infusion line portion for a solution at least partially reestablishing blood ion balance, the post-infusion line portion having a post-infusion line passage section; a first main channel in fluid communication with the first line portion and having a first passage section,', 'a second main channel in fluid communication with the second line portion and having a second passage section,', 'means for the formation of a turbulence area located downstream from and in fluid communication with the first main channel, located upstream from and in fluid communication with the second main channel, the means for formation of a turbulence comprising a first fluid passage means defining a reduction in the passage section and whose smallest passage section is smaller than the first passage section and smaller than the second fluid passage section, wherein the first fluid passage of the turbulence area formation means defines a continuous narrowing of internal section in the direction of fluid passage;', 'a secondary channel in fluid communication with the post-infusion line portion, the secondary channel comprising an inlet for letting in a solution reestablishing ion balance and an outlet in fluid communication with at least one of the three elements chosen among the first main channel, the means for the formation of a turbulence area and the second main channel, wherein, 'an infusion site acting between the first line portion and the second line portion, and intended to inject into the blood ...

Portable Dialysis Machine with Improved Reservoir Heating System

The specification discloses a portable dialysis machine having a detachable controller unit and base unit with an improved reservoir heating system. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a reservoir with an internal pan and external pan, separated by a space that holds a heating element. The heating element is electrically coupled to electrical contacts attached to the external surface of the external pan. 1. A dialysis machine having a reservoir unit wherein said reservoir unit comprises:a. a first housing having an external surface and an internal surface and defining a first volume adapted to hold a fluid therein;b. a second housing having an external surface and an internal surface and defining a second volume adapted to house the first housing with a space between the external surface of the first housing and the internal surface of the second housing;c. a heating element positioned within the space between the external surface of the first housing and the internal surface of the second housing; andd. a first plurality of electrical contacts attached to the external surface of the second housing and electrically coupled to the heating element.2. The dialysis machine of claim 1 , wherein said first housing is fused to said second housing.3. The dialysis machine of claim 1 , wherein said heating element is a heating pad and wherein said heating pad is rated in a range from 300 W to 600 W.4. The dialysis machine of claim 3 , wherein said heating pad is configured to heat from 1 to 6 liters of a fluid claim 3 , located within said first volume claim 3 , to a temperature within a range of 36 to 39 degrees C. within 15 to 45 minutes.5. The dialysis machine of claim 1 , wherein said first housing is a pan and wherein the first volume is at least ...

METHOD OF REMOVING BLOOD FROM AN EXTRACORPOREAL BLOOD CIRCUIT, TREATMENT APPARATUS, AND TUBE SYSTEM

The present invention relates to a method of removing blood from an extracorporeal blood circuit following termination of a blood treatment session, wherein blood is concurrently removed both from an arterial conduit portion and from a venous conduit portion of the extracorporeal blood circuit. It further relates to a method for recognizing and/or eliminating air inclusions in or from an extracorporeal blood circuit and a treatment apparatus as well as a tube system. 148-. (canceled)49. A method of removing blood from an extracorporeal blood circuit of a treatment apparatus following termination of a blood treatment session , the method comprising: at least one device adapted to receive the extracorporeal blood circuit, the extracorporeal blood circuit including an arterial conduit portion and a venous conduit portion;', 'at least one blood pump arranged along the extracorporeal blood circuit and adapted to convey blood within the extracorporeal blood circuit; and', 'at least one conveyor adapted to at least one of (i) introduce substituate liquid into the extracorporeal blood circuit and (ii) convey the substituate liquid within the extracorporeal blood circuit;, 'providing the treatment apparatus comprisingintroducing, using the conveyor, the substituate liquid into the extracorporeal blood circuit; andconveying, using at least one of the blood pump and the conveyor, the substituate liquid within the extracorporeal blood circuit to concurrently remove blood both from the arterial conduit portion and from the venous conduit portion of the extracorporeal blood circuit.50. The method according to claim 49 , wherein the blood is removed from the extracorporeal blood circuit while concurrently operating the blood pump and the conveyor.51. The method according to claim 50 , wherein the blood pump has a conveying capacity or conveying rate that is controlled or regulated based on at least one of a parameter relating to the extracorporeal blood circuit and a conveying ...

BLOOD RINSEBACK SYSTEM AND METHOD

A hemodialysis system is provided and includes a dialyzer, a dialysis fluid circuit in fluid communication with the dialyzer, a blood circuit, a blood detector and a blood rinseback scheme, wherein the blood rinseback scheme includes transferring blood to the patient using a physiologically acceptable fluid, wherein the physiologically acceptable fluid is introduced from its source into an arterial line between an arterial line patient end and a blood pump of the blood circuit, and flowed through the dialyzer, through a venous drip chamber and to the blood detector along a venous line of the blood circuit, where the physiologically acceptable fluid is sensed by the blood detector to indicate an end of the blood rinseback. 1. A hemodialysis system configured to return blood to a patient , the hemodialysis system comprising:a dialyzer; a fresh dialysis fluid pump,', 'a used dialysis fluid pump,', 'a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and', 'a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;, 'a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including'} an arterial line for removing blood from a patient and delivering the blood to the dialyzer,', 'a venous line for returning blood from the dialyzer to the patient,', 'a blood pump operable with the arterial line upstream of the dialyzer,', 'a physiologically acceptable fluid source in fluid communication with the arterial line between a patient end of the arterial line and the blood pump,', 'a drip chamber located along the venous line;, 'a blood circuit in fluid communication with the dialyzer and including'}a ...

SYSTEMS AND METHODS FOR PRIMING HEMODIALYSIS USING MULTIPLE FLUID SOURCES

A hemodialysis system configured to purge air from a blood circuit comprising: a dialyzer; a dialysis fluid circuit operable with the dialyzer via dialysis fluid inlet and outlet lines; the blood circuit operable with the dialyzer and including an arterial line, a venous line, a blood pump operable with the arterial line upstream of the dialyzer, and a physiologically acceptable fluid source in fluid communication with the arterial line upstream of the blood pump; and an air purging scheme wherein, with the dialysis fluid inlet and outlet lines connected to the dialyzer, air is purged using dialysis fluid or other physiologically acceptable fluid pumped by at least one of the fresh or used dialysis fluid pumps from the dialysis fluid circuit, through the dialyzer, into the blood circuit, in combination with dialysis fluid or other physiologically acceptable fluid from the source introduced directly into the blood circuit. 1. A hemodialysis system configured to purge air from a blood circuit , the hemodialysis system comprising:a dialyzer; a fresh dialysis fluid pump,', 'a used dialysis fluid pump,', 'a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and', 'a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;, 'a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including'} an arterial line for removing blood from a patient and delivering the blood to the dialyzer,', 'a venous line for returning blood from the dialyzer to the patient,', 'a blood pump operable with the arterial line upstream of the dialyzer,', 'a physiologically acceptable fluid source in fluid communication ...

Method for removing fluid from a blood filter after completing a blood treatment session by means of flow increase and treatment device for carrying out said method

The present invention relates to a method for removing fluid from a blood filter ( 19 ) for the blood treatment of a patient and/or for removing blood from the flood filter ( 19 ) after completing the blood treatment session. It further relates to a control and/or regulating device ( 29 ), a medical treatment apparatus having a control and/or regulating device ( 29 ) with which the method according to the present invention is executable, a digital storage medium, a computer program product as well as a computer program.

Medical apparatus for extracorporeal treatment of fluid and a process of calculating set flow rates in a medical apparatus for delivery or collection of fluids

An apparatus for extracorporeal treatment of fluid and a process of setting up a medical apparatus for the delivery or collection of fluids are disclosed. According to the apparatus and the process, a control unit ( 10 ) is configured calculate set values of two or more of the fluid flow rates by imposing that an emptying time of containers of fresh fluid ( 16, 20, 21, 26 ) and/or a filling time of a waste container is substantially same as, or multiple of, the emptying time of one or more of the other containers of fresh fluid.

Apparatus and a method for extracorporeal blood treatment

An apparatus for extracorporeal blood treatment comprises a sensor ( 10 ) for emitting a signal indicating a variation in blood volume (ΔBv″) of an individual ( 7 ) subjected to extracorporeal blood treatment and a sensor ( 14 ) for emitting a signal indicating a weight loss of the individual. A control unit ( 20 ) receives the signals, compares the ratio between the relative variation of blood volume (ΔBv/BV) and the relative variation of weight loss (AWL/TW) of the individual with a desired value, and controls the weight loss of the individual on the basis of the comparison. The apparatus enables automatically controlling a dialysis, preventing some complications due to hypotension.

RENAL FAILURE THERAPY MACHINES AND METHODS INCLUDING CONVECTIVE AND DIFFUSIVE CLEARANCE

A renal failure therapy machine includes a blood cleaning filter, a dialysis fluid circuit including a balance chamber, the balance chamber including a fresh dialysis fluid compartment configured to send fresh dialysis fluid to the blood cleaning filter and a used dialysis fluid compartment configured to receive used dialysis fluid from the blood cleaning filter, a fresh dialysis fluid line in fluid communication with the fresh dialysis fluid compartment of the balance chamber and the blood cleaning filter, and a flow restrictor in fluid communication with the blood cleaning filter, the flow restrictor configured to cause fresh dialysis fluid delivered from the fresh dialysis fluid compartment, through the fresh dialysis fluid line, to the blood cleaning filter to be pressurized so that a first amount of the fresh dialysis fluid performs convective clearance and a second amount of the fresh dialysis fluid performs diffusive clearance. 1. A renal failure therapy machine comprising:a blood cleaning filter;a dialysis fluid circuit including a balance chamber, the balance chamber including a fresh dialysis fluid compartment configured to send fresh dialysis fluid to the blood cleaning filter and a used dialysis fluid compartment configured to receive used dialysis fluid from the blood cleaning filter;a fresh dialysis fluid line in fluid communication with the fresh dialysis fluid compartment of the balance chamber and the blood cleaning filter; anda flow restrictor in fluid communication with the blood cleaning filter, the flow restrictor configured to cause fresh dialysis fluid delivered from the fresh dialysis fluid compartment, through the fresh dialysis fluid line, to the blood cleaning filter to be pressurized so that a first amount of the fresh dialysis fluid performs convective clearance and a second amount of the fresh dialysis fluid performs diffusive clearance.2. The renal failure therapy machine of claim 1 , which operates the flow restrictor to cause the ...

EXTRACORPOREAL CIRCUIT FOR REMOVAL OF CO2 FROM BLOOD

The present invention concerns an extracorporeal circuit for removing COfrom blood comprising a blood withdrawal line for withdrawing blood from the patient, a filtration unit for producing plasma water and a line for returning the blood to the patient, defining a main circuit; the extracorporeal circuit further comprises a decarbonating group comprising a secondary circuit for the recirculation of plasma water, means for removing a fraction of said plasma water, a COexchanger, a cationic resin charged with H+ ions set upstream of the COexchanger and adapted to generate acid plasma water, means for the infusion of the acid plasma water upstream of the COexchanger and means for the infusion of ions in a solution downstream of the COexchanger. 11100200300400500263054047123091093015309119aa. An extracorporeal circuit ( , , , , , ) for removing COfrom blood comprising a blood withdrawal line () for withdrawing blood from a patient , a filtration unit () for producing plasma water () and a line for returning the blood () to the patient , defining a main circuit (); said extracorporeal circuit being characterised in that it comprises a decarbonating group () comprising a secondary circuit () for recirculation of plasma water , means () for removing a fraction of said plasma water () , a COexchanger () , a cationic resin charged with H+ ions () set upstream of said COexchanger () and adapted to generate acid plasma water () , means () for infusion of said acid plasma water () upstream of said COexchanger () and means () for infusion of ions in a solution downstream of said COexchanger ().26. The extracorporeal circuit according to claim 1 , characterised in that said filtration unit () is a filter selected from the group consisting of a haemodialysis filter claim 1 , a haemofilter and a dialyser.3. The extracorporeal circuit according to claim 1 , characterised in that said cationic resin charged with H+ ions is selected from the group consisting of a cationic resin ...

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. 1. A system for regulating balanced flow of fluids , comprising:a fluid circuit with first and second fluid channels connectable to a fluid handling device, each with at least one respective pump for each of said first and second fluid channels, a controller connected to the respective pumps to control a rate of pumping of one or more of said respective pumps, the controller being connected to one or more valves to permit it to establish flows in the first and second channels;a ratio of flow rates of entering and leaving flows to and from the fluid handling device is controlled by said controller to effect a predefined net transfer of fluid to or from the fluid handling device responsively to calibration data accessible to said controller;the controller, at selected times, temporarily establishing one or more calibration flow paths in said fluid circuit, the calibration flow paths communicating respectively with ones of said first and second fluid channels to cause flow through a flow measurement component that generates a signal indicating a flow rate or relative flow rate generated by said respective pumps;the controller sampling the signal and in response to resulting samples, the controller adjusting said calibration data;the controller, using the adjusted calibration data stored in said controller to adjust the one or more of said respective pumps in order to effect said predefined net transfer of fluid to or from the fluid handling device;the selected times being determined by the controller responsively to detection ...

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. 1. A medical treatment method , comprising:at treatment times, using peristaltic pumps, flowing medicament into and out of inflow and outflow channels connectable to a patient or treatment device;at calibration times, over a calibration interval of less than a minute, flowing medicament directly between the inflow and outflow channels such that pulsations generated by the peristaltic pumps cause pressure in a bridge channel between the inflow and outflow channels to fluctuate due to a superposition of a suction side pulsation and a pressure side pulsation of respective ones of said peristaltic pumps; andusing an adjustable flow restrictor, selecting a suction head of at least one of the respective ones of the peristaltic pumps so as to change a pulsation frequency thereof so that it differs from that of the other of the ones of the peristaltic pumps by a predetermined amount.2. The method of claim 1 , wherein the predetermined amount is such that a ratio of an inverse of a difference between pulsation frequencies of the ones of the peristaltic pumps is multiple times the calibration interval.3. The method of claim 1 , wherein the predetermined amount is such that a ratio of an inverse of a difference between pulsation frequencies of the ones of the peristaltic pumps is three times the calibration interval.4. The method of claim 1 , wherein the predetermined amount is such that a ratio of an inverse of a difference between pulsation frequencies of the ones of the peristaltic pumps is five times the calibration interval.5. The ...

MEDICAL APPARATUS FOR EXTRACORPOREAL TREATMENT OF FLUID AND A PROCESS OF CALCULATING SET FLOW RATES IN A MEDICAL APPARATUS FOR DELIVERY OR COLLECTION OF FLUIDS

An apparatus for extracorporeal treatment of fluid and a process of setting up a medical apparatus for the delivery or collection of fluids are disclosed. According to the apparatus and the process, a control unit () is configured calculate set values of two or more of the fluid flow rates by imposing that an emptying time of containers of fresh fluid () and/or a filling time of a waste container is substantially same as, or multiple of, the emptying time of one or more of the other containers of fresh fluid. 128-. (canceled)29. An apparatus for extracorporeal treatment of fluid comprising:a filtration unit having a primary chamber and a secondary chamber separated by a semi-permeable membrane;a blood withdrawal line connected to an inlet of the primary chamber and a blood return line connected to an outlet of the primary chamber, the blood withdrawal line and the blood return line configured to connect to a patient cardiovascular system;a blood pump configured to control the flow of blood through the blood withdrawal line and the blood return line;an effluent fluid line connected, at one end thereof, to an outlet of the secondary chamber and at its other end to a waste container; a pre-dilution infusion fluid line connected at one end thereof to the blood withdrawal line and at its other end to a first container of fresh fluid,', 'a post-dilution infusion fluid line connected at one end thereof to the blood return line and at its other end to a second container of fresh fluid,', 'a dialysis liquid fluid line connected at one end thereof to an inlet of the secondary chamber and at its other end to a third container of fresh fluid, and', 'a pre-blood pump infusion fluid line connected at one end thereof to a fourth container of fresh fluid and at its other end to the blood withdrawal line in a region of the blood withdrawal line which is positioned in use upstream the blood pump;, 'at least two fluid lines selected from the group of fluid lines comprisinga control ...

Liver support system

An artificial, extracorporeal system for liver replacement and/or assistance, comprises a liver dialysis device for conducting hemodialysis on a patient suffering from liver failure. The liver dialysis device comprises a first standard hollow fiber membrane dialyzer which does not allow passage of an essential amount of albumin over the membrane wall and which is perfused with the patient's blood, and a second hollow fiber membrane dialyzer which allows the passage of essential but defined amounts of albumin over the membrane wall and which receives the blood of the first standard hemodialyzer. The filtrate space is closed off from the lumen space of the hollow fibers and is populated by adsorbent material which may comprise one or more different adsorbents.

DEGASSER AND VENT MANIFOLDS FOR DIALYSIS

The invention relates to a degasser manifold and a vent manifold for use with a degasser in a dialysis system. The degasser manifold and vent manifold include a plurality of fluid passageways that convey dialysate or gases into and out of the degasser. The degasser manifold and vent manifold can also include components such as valves and sensors for control over the degassing of dialysate. 1. A degasser manifold , comprising:a plurality of passageways fluidly connectable to one or more inlets and one or more outlets in a dialysis system;the one or more inlets comprising a first inlet fluidly connectable to a first fluid line, the first fluid line fluidly connectable to a dialysate flow path, and a second inlet fluidly connectable to a second fluid line; the second fluid line fluidly connectable to an outlet of a degasser;the one or more outlets comprising a first outlet fluidly connectable to an inlet of the degasser and a second outlet fluidly connectable to a third fluid line, the third fluid line fluidly connectable to the dialysate flow path downstream of the first fluid line.2. The degasser manifold of claim 1 , further comprising a second fluid passageway from the second inlet to the first fluid passageway.3. The degasser manifold of claim 2 , further comprising a pressure sensor in a fluid passageway between the first inlet and the first outlet.4. The degasser manifold of claim 2 , claim 2 , or claim 2 , further comprising a second fluid passageway from the first fluid passageway to the second outlet.5. The degasser manifold of claim 1 , the second fluid line comprising a first fluid pump.6. The degasser manifold of claim 5 , further comprising a controller; the controller controlling the first fluid pump and a dialysate pump to control a ratio of fluid passing to the first outlet and second outlet.7. The degasser manifold of claim 6 , the controller controlling the ratio of fluid passing to the first outlet and the second outlet based on a fluid pressure ...

DEVICE FOR REMOVING NOXAE FROM BLOOD, EXTRACORPOREAL PERFUSION SYSTEM COMPRISING SUCH A DEVICE AND METHOD OF MANUFACTURING SUCH A DEVICE

A device for removing noxae from blood, in an extracorporeal perfusion system, includes a housing and a plurality of hollow fibers provided inside the housing, which can be perfused by the blood. The hollow fibers each have a plurality of pores that permit the plasma of the blood to flow through the pores from an inside of the hollow fibers to an outside of the hollow fibers. The hollow fibers are modified or pretreated, in particular chemically, in such a way that they have a functionalized surface which binds the noxae to itself and removes the noxae from the blood. An inside surface of the hollow fibers includes a coating, in particular a hemocompatible and anticoagulant coating, which is arranged to prevent damage to the cellular components of the blood when the blood flows through the hollow fibers. An extracorporeal perfusion system includes the device. 1. A device for removing noxae from blood which comprises plasma and cellular components in an extracorporeal perfusion system , comprising:a housing and a plurality of hollow fibers provided inside the housing and configured to be perfused by the blood, whereinthe hollow fibers each have a plurality of pores configured such that the plasma of the blood can flow through the pores from an inside of the hollow fibers to an outside of the hollow fibers, and whereinthe hollow fibers are modified or pretreated in such a way that they have a functionalized surface which binds the noxae to itself and removes the noxae from the blood, whereinan inside surface of the hollow fibers is further provided with a coating which is configured to prevent damage of the cellular components of the blood when the blood flows through the hollow fibers.2. The device according to claim 1 , wherein the coating is arranged or formed on the inside surface of the hollow fibers in such a way that the inner circumferential sides of the pores are not covered or incompletely covered by the coating.3. The device according to claim 1 , wherein ...

Filter device, system and method for filtration of fluids

A filter device (10) for filtration of fluids, in particular for the dialysis of blood. The filter device (10) comprises a housing (12) having a first end (14) and a second end (16) and defining a fluid chamber (18) extending between the first end (14) and the second end (16). The filter device (10) further comprises a first lid (20) provided at the first end (14) of the housing (12) and comprising a first fluid port (22), a first compartment (24), a second compartment (26) and a first internal separating wall (28) separating the first compartment (24) from the second compartment (26). The filter device (10) further comprises a second lid (30) provided at the second end (16) of the housing (12) and comprising a second fluid port (32), a third fluid port (33), a third compartment (34), a fourth compartment (36) and a second internal separating wall (38) separating the third compartment (34) from the fourth compartment (36). The filter device (10) further comprises a plurality of hollow fibers (40) arranged within the housing (12), wherein each of the plurality of hollow fibers (40) comprises a semi-permeable membrane and defines a fluid channel extending longitudinally through an interior of the respective hollow fiber (40). The filter device (10) further comprises a first sealing means (42) which separates the fluid chamber (18) from the first and the second compartment (24, 26), the first sealing means (42) having a first longitudinal end facing away from the second lid (30). The filter device (10) further comprises a second sealing means (46) which separates the fluid chamber (18) from the third and the fourth compartment (34, 36), the second sealing means (46) having a second longitudinal end facing away from the first lid (20). Still further, the filter device (10) comprises a fourth fluid port (50) and a fifth fluid port (52) both provided at the fluid chamber (18) and located between the first longitudinal end of the first sealing means (42) and the second ...

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. 1. A medical treatment system , comprising:a first fluid management element that pumps fluid from a patient interface device during a treatment;a second fluid management element that pumps fluid into a patient interface device during a treatment;the patient interface device being a device that interfaces with a patient fluidcompartment including at least one of a dialyzer, a hemofilter, a hemodiafilter, an ultrafilter, and a plasmapheresis device;a controller connected to at least one of the first and second fluid management elements and having a processor programmed to regulate a net transfer of fluid into or from the patient interface device to achieve a predefined net removal of fluid from the patient during a therapeutic treatment implemented under control of the controller;a fluid circuit switch that allows a flow from at least one of the first and second fluid management elements to be selectively and automatically configured under control of the controller between a therapy configuration for delivering said therapeutic treatment to a calibration configuration in which flow through said at least one of the first and second fluid management elements is temporarily diverted to a flow or pressure sensor that outputs a signal indicating a difference between the flow rates of the first and second fluid management elements;the controller being programmed to calculate and store flow correction data representing a correction to be applied to a rate of flow of said at least one of the first and second fluid management elements ...

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

An apparatus for extracorporeal blood treatment, comprising a treatment unit () having a first chamber () and a second chamber () separated from one another by a semipermeable membrane (), a blood removal line () connected in inlet with the first chamber () and a blood return line () connected in outlet with the first chamber; an infusion line () of a replacement fluid and a fluid evacuation line () connected in outlet from the second chamber. A regulating device () of a transmembrane pressure is active on at least one of the lines and a control unit () is configured to: command the regulating device () by setting a first increase (δTMP), determine a value of a control parameter (φ) corresponding to the first increase, compare the value of the control parameter (φ) with a reference value (φ) and, if the value of the control parameter is greater than the reference value, command the regulating device () by setting a second increase (δTMP) which is greater than the first increase (δTMP). 120-. (canceled)21. A process of setting transmembrane pressure between a first chamber and a second chamber of a treatment unit in an apparatus for extracorporeal blood treatment , at least one blood removal line connected with an inlet port of the first chamber and predisposed to remove blood from a patient;', 'at least one blood return line connected to an outlet port of the first chamber and predisposed to return treated blood to the patient;', 'at least one infusion line for providing replacement fluid, the at least one infusion line connected to one of said at least one blood removal line and said at least one blood return line;', 'at least one fluid evacuation line connected to an outlet port of the second chamber configured to receive at least one fluid filtered across the semipermeable membrane;, 'the apparatus comprisingthe treatment unit having the first chamber and the second chamber separated from one another by a semipermeable membrane, wherein a difference in pressures ...

DIALYSIS MACHINE

The invention relates to a dialysis machine having an extracorporeal blood circuit, a blood pump, a dialyzer, a venous pressure sensor, a substituate line, and a control unit, wherein the control unit is configured to operate the blood pump in a first operating mode and in a special operating mode and to start the special operating mode after recognition of a trigger event, in which special operating mode a conveying rate of the blood pump is controlled by means of a default value or is regulated to a desired value, which default or desired value is derived from a value determined before the start of the currently started special operating mode or corresponds to said value, wherein the presence of at least one obstacle is polled before the start of the special operating mode, and wherein, on the presence of the obstacle, the start of the special operating mode is blocked or delayed and/or the selection of the default value or of the desire value on the presence of the obstacle differs from the selection without the presence of the obstacle. 1. A dialysis machine having an extracorporeal blood circuit , a blood pump , a dialyzer , a venous pressure sensor , a substituate line , and a control unit , wherein the control unit is configured to operate the blood pump in a first operating mode and in a special operating mode and to start the special operating mode after recognition of a trigger event , in which special operating mode a conveying rate of the blood pump is controlled by means of a default value or is regulated to a desired value , which default or desired value is derived from a value determined before the start of the currently started special operating mode or corresponds to said value , characterized in thatthe control unit is furthermore configured such that the presence of at least one obstacle is polled before the start of the special operating mode; and in that, on the presence of the obstacle, the start of the special operating mode is blocked or ...

APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD INCLUDING CALCULATION OF FLOW RATES THEREFORE

An apparatus for extracorporeal treatment of fluid and a process of setting up a medical apparatus for the delivery or collection of fluids are disclosed. According to the apparatus and the process, a control unit () is configured calculate set values of two or more of the fluid flow rates based on a fluid flow rate set by the operator and on a prescribed dose value (D). 1. An apparatus for extracorporeal treatment of blood comprising:a filtration unit including a primary chamber and a secondary chamber separated by a semi-permeable membrane;a blood withdrawal line in fluid communication with an inlet of the primary chamber;a blood return line in fluid communication with an outlet of the primary chamber, said blood withdrawal and return lines configured to connect to a patient;a blood pump configured to pump blood through at least one of the blood lines;an effluent fluid line in fluid communication with an outlet of the secondary chamber;at least two further fluid lines selected from a group includinga pre-dilution infusion fluid line in fluid communication with the blood withdrawal line,a post-dilution infusion fluid line in fluid communication with the blood return line,a dialysis fluid line in fluid communication with an inlet of the secondary chamber, anda pre-blood pump infusion fluid line in fluid communication with the blood withdrawal line at a location upstream of the blood pump;a plurality of fluid pumps configured to pump fluid through said fluid lines; anda control unit operably connected to said pumps and to a memory, the control unit configured to:enter in the memory a set value for at least a first fluid flow rate selected from a group of fluid flow rates including{'sub': 'rep1', 'a fluid flow rate Qthrough the pre-dilution infusion fluid line,'}{'sub': 'rep2', 'a fluid flow rate Qthrough the post-dilution infusion fluid line,'}{'sub': 'pbp', 'a fluid flow rate Qthrough the pre-blood pump infusion fluid line,'}{'sub': 'dial', 'claim-text': {'sub': ' ...

METHOD OF REMOVING BLOOD FROM AN EXTRACORPOREAL BLOOD CIRCUIT, TREATMENT APPARATUS, AND TUBE SYSTEM

The present invention relates to a method of removing blood from an extracorporeal blood circuit following termination of a blood treatment session, wherein blood is concurrently removed both from an arterial conduit portion and from a venous conduit portion of the extracorporeal blood circuit. It further relates to a method for recognizing and/or eliminating air inclusions in or from an extracorporeal blood circuit and a treatment apparatus as well as a tube system. 1. (canceled)2. A treatment apparatus comprising: a dialyzer;', 'a solution supply line connected to the dialyzer and a solution source;', 'an outlet line connected to the dialyzer;', 'an arterial conduit portion connected to the dialyzer; and', 'a venous conduit portion connected to the dialyzer and including a venous needle;, 'a fluid conveyance system comprisinga blood pump arranged along the fluid conveyance system and adapted to convey blood within the fluid conveyance system;a second pump arranged along the fluid conveyance system and adapted to pump a liquid, via a liquid feed conduit, into the fluid conveyance system at an addition site along fluid conveyance system; andat least one controller configured to concurrently remove blood, using the liquid pumped by the second pump into the fluid conveyance system while a patient is connected to the treatment apparatus, from both the arterial conduit portion and from the venous conduit portion of the fluid conveyance system.3. The treatment apparatus of claim 2 , wherein the arterial conduit portion includes an arterial patient tube clamp and the venous conduit portion includes a venous patient tube clamp.4. The treatment apparatus of claim 3 , wherein claim 3 , during the removal of blood from the arterial conduit portion and from the venous conduit portion claim 3 , both the arterial patient tube clamp and the venous patient tube clamp are in an opened state.5. The treatment apparatus of claim 2 , wherein the liquid pumped by the second pump into ...

An apparatus for extracorporeal blood treatment

It is disclosed an apparatus for extracorporeal blood treatment ( 1 ) having a control unit ( 15 ) connected to an ultrafiltration device ( 20 ) and to a fluid preparation section ( 30 ) of fresh dialysis liquid. The control unit ( 15 ) is configured to receive measured values of the change of blood volume, the amount of ultrafiltration volume, and conductivity or to the concentration for at least one substance in the blood (BV % mes(t) ; U Fmes(t) , WL mes(t) ; Cb mes(t)) ; the control unit ( 15 ) is also configured to receive prescription values for the same parameters and to control ultrafiltration and adjust conductivity in the fresh dialysis liquid based on the difference between said measured values and said prescription values.

Methods and Devices for the Enrichment of Immunoglobulin from Blood

In some embodiments, the invention provides a method for extracting at least 55% of immunoglobulin such as IgG present in a biological fluid from the biological fluid, comprising contacting a biological fluid suspected of containing immunoglobulin with a solid support covalently bonded to a ligand that specifically binds to immunoglobulin under conditions sufficient for non-covalent binding of immunoglobulin to the ligand; and contacting the solid support with an elution solution under condition whereby the noncovalently bound immunoglobulin is released from the ligand and into the elution solution, wherein at least 55% of the IgG present in the biological fluid is extracted into the elution solution. In some embodiments, the invention provides a method for enriching immunoglobulin from a biological fluid comprising obtaining an initial biological fluid suspected of containing immunoglobulin and removing non-immunoglobulin components naturally occurring in the initial biological fluid to obtain a non-immunoglobulin componentreduced biological fluid. 1. A method for extracting at least 55% of immunoglobulin , such as IgG , present in a biological fluid from the biological fluid comprising:(a) contacting a biological fluid suspected of containing the immunoglobulin with a solid support covalently bonded to a ligand that specifically binds to the immunoglobulin under conditions sufficient for non-covalent binding of immunoglobulin in the biological fluid to the ligand; and(b) contacting the solid support with an elution solution under condition whereby the non-covalently bound immunoglobulin is released from the ligand and into the elution solution,wherein at least 55% of the immunoglobulin present in the biological fluid is extracted into the elution solution.2. The method of claim 1 , comprising repeating step (a) at least once prior to step (b).3. The method of claim 1 , wherein the extracted immunoglobulin in the elution solution is purified immunoglobulin.4. The ...

Infusion site for improved mixing of fluids

The invention relates to a blood line ( 108 ) comprising an infusion site ( 145 ) intended to inject into the line a solution comprising: —a first main channel ( 200 ) having a first passage section, —a second main channel ( 220 ) having a second passage section, —means for the formation ( 210 ) of a turbulence area located downstream from the first main channel, located upstream from the second main channel, these formation means comprising a first fluid passage means ( 224 ) defining a reduction ( 225 ) in the passage section and whose smallest passage section is smaller than the first passage section and smaller than the second fluid passage section, —a secondary channel ( 230 ) comprising an inlet ( 231 ) for letting in the solution and an outlet ( 232 ) in fluid communication with the first main channel or the means for the formation of a turbulence area or the second main channel.

APPARATUS FOR CARRYING OUT AN EXTRACORPOREAL BLOOD TREATMENT

The invention relates to an apparatus for carrying out an extracorporeal blood treatment in which a substitution fluid is administered to the patient, wherein the apparatus comprises an extracorporeal blood circuit and a substitution line opening into the extracorporeal blood circuit, wherein the substitution line has at least one heating container, and wherein a pump is arranged in the substitution line downstream of the heating container or containers for the conveying of substitution fluid into the extracorporeal blood circuit. 112512528. An apparatus for carrying out an extracorporeal blood treatment in which a substitution fluid is administered to the patient , wherein the apparatus comprises an extracorporeal blood circuit () and a substitution line () opening into the extracorporeal circuit blood circuit () , and wherein the substitution line () has at least one heating container () ,characterized in that{'b': 27', '31', '28', '25', '1, 'a pump (, ) is arranged downstream of the heating container or containers () in the substitution line () for conveying substitution fluid into the extracorporeal blood circuit ().'}234. An apparatus in accordance with claim 1 , characterized in that a clamp () which inhibits the flow of substitution fluid in the closed state is arranged upstream of the heating container or containers in the substitution line.3273427. An apparatus in accordance with claim 2 , characterized in that the apparatus furthermore has a control unit which is connected to the pump () and claim 2 , optionally claim 2 , furthermore to the clamp () and is configured such that the clamp is closed and the pump () is operated in an operating mode of the apparatus.42528282727282725. An apparatus in accordance with claim 1 , characterized in that a respective at least one interface at which the substitution line () can be separated is arranged upstream of the heating container or containers () claim 1 , between the heating container or containers () and the ...

Patient and treatment records

The exemplary systems and methods may generate treatment records for extracorporeal blood treatments. The treatment records may include a plurality of values of various parameters. The various parameters may include a compulsory set of parameters that are preset, a dependent set of parameters that a dependent on one or more of a selected treatment and a system configuration, and a discretionary set of parameters that are selected by a user.

System and Methods Incorporating Replacement Fluid Maximization

A processing system includes a processor including a separator, a set configured to cooperate with the separator to separate whole blood into plasma and other components, the set including an inlet line attachable to a patient to receive whole blood and an return line attachable to a patient to return processed fluid, and a source of replacement fluid connected to the disposable set, the processor configured to combine the other components with replacement fluid to define the processed fluid. The processor includes a controller and an input device coupled to the controller, the controller configured to receive an input via the input device, the input representing a volume of replacement fluid, and to control the processor to separate whole blood passing through the set and to combine the other components with the replacement fluid according to the input until the source of replacement fluid is empty.

Solution circuit apparatus with bypass, and blood purification system comprising the solution circuit apparatus

A solution circuit apparatus for a blood purification system having an extracorporeal blood circuit. The solution circuit apparatus includes a solution source; a warmer having a temperature sensor; a bypass branch; a delivery branch communicating with the extracorporeal blood circuit; a pump; a switch; and a control unit configured to set the solution circuit apparatus into one of a solution delivery condition and a solution stop condition. In the solution delivery condition the switch interrupts the bypass branch, and the pump delivers solution via the warmer and through the delivery branch. In the solution stop condition the switch interrupts the delivery branch, and the pump recirculates solution through the warmer via the bypass branch. In the therapy stop condition the pump rate is dependent on the output of the temperature sensor.

EXTRACORPOREAL BLOOD TREATMENT APPARATUS AND METHOD OF SETTING AN EXTRACORPOREAL BLOOD TREATMENT

It is described an extracorporeal blood treatment apparatus () with a user interface () device capable configuring and allowing execution of one or more isolated ultrafiltration tasks during the course of a dialysis treatment. The extracorporeal blood treatment apparatus () is controlled in a normal mode, where dialysis fluid is fed to the blood treatment unit (), and in an isolated ultrafiltration mode, where fresh dialysis fluid is no longer fed to the blood treatment unit (). 1. An extracorporeal blood treatment apparatus comprising:a blood treatment unit having a primary chamber configured to receive blood of a patient to be treated, and a secondary chamber separated from the primary chamber by a semi-permeable membrane;an hydraulic circuit having a fresh fluid line configured to connect to an inlet of the secondary chamber, and a spent fluid line configured to connect to an outlet of said secondary chamber and configured to remove spent liquid from the secondary chamber and convey it to at least one waste,a control unit operably connected to the hydraulic circuit and configured to control the hydraulic circuit to selectively operate in a normal mode, where the fresh fluid line is connected to the inlet of the secondary chamber of the treatment unit and conveys fresh treatment liquid to the secondary chamber, and wherein the control unit is further configured to control the hydraulic circuit to selectively operate in an isolated ultrafiltration mode, where the fresh fluid line does not convey fresh treatment liquid to the secondary chamber,the control unit further configured to execute a setup phase before starting treatment, the setup phase comprising: a prescription value for a total treatment time during which the patient is to be submitted to blood treatment,', 'a prescription value for a total patient fluid removal to be achieved by the end of total treatment time,', 'a prescription value for an average patient fluid removal rate to be kept across total ...

MODULAR FLUID THERAPY SYSTEM HAVING JUMPERED FLOW PATHS AND SYSTEMS AND METHODS FOR CLEANING AND DISINFECTION

Systems and methods for cleaning and disinfecting a medical therapy device that delivers any one of hemodialysis, hemodiafiltration and hemofiltration. The system has a base module that has at least one segment of a controlled compliant flow path and at least one pair of jumpered ports configured on the base module. One or more components have connections connectable to the jumpered ports of the base module to provide for fluid communication between the segment of the controlled compliant flow path in the base module and a flow path defined by the one or more components. The base module is connected to the one or more components that define a flow path configurable for carrying out in part at least one function performed during any one of hemodialysis, hemodiafiltration or hemofiltration. 168- (canceled)69. A system , comprising:a base module having at least one segment of a flow path and at least one pair of jumpered ports configured on the base module alternatively connectable to a cleaning manifold and therapy cassette, the therapy cassette containing at least one conduit and any one or more of concentrates, cartridges, sensors elements, reservoirs, filters, and vents, the cleaning manifold and therapy cassette connectable to the jumpered ports of the base module and defining a flow path carrying out in part at least one function performed during any one of hemodialysis, hemodiafiltration, or hemofiltration;said cleaning manifold and therapy cassette having connections connectable to the jumpered ports of the base module to provide for fluid communication between the segment of the flow path in the base module and a flow path defined by the cleaning manifold or therapy cassette wherein the cleaning manifold and therapy cassette are detachable from the segment of the flow path; andwherein the base module connected to the cleaning manifold or therapy cassette defines a flow path configurable for carrying out in part at least one function performed during any one of ...

IMPLANTABLE RENAL REPLACEMENT THERAPY

Various types of a medical device are described which is used as an implantable renal replacement therapy (an implantable artificial kidney). This device removes toxins and excess water from blood of patients with kidney failure or end stage renal disease. Additionally, other configurations of the device can be used as an external (extracorporeal) device. 151-. (canceled)52. A blood filtration system , comprisingan arterial connection;a filtration system having a feed side, a filtrate side and a non-silicon ceramic filter separating the feed side and the filtrate side, the feed side in fluid communication with the arterial connection;a re-absorption system having a feed side, a filtrate side and a non-silicon ceramic filter separating the feed side and the filtrate side, the filtrate side of the filtration system in fluid communication with the feed side of the re-absorption system;a venous connection in fluid communication with the filtrate side of the filtration system; anda housing comprising the filtration system and the re-absorption system.53. The system of claim 52 , further comprising a pump positioned between the filtration system and the re-absorption system.54. The system of claim 52 , further comprising a percutaneous drive line including a fluid supply channel claim 52 , a fluid return channel claim 52 , a power cable claim 52 , and a data communications cable.55. The system of claim 54 , further comprising a filtration system inlet valve in communication with the fluid supply channel and an inlet to the filtration system filtrate side56. The system of claim 54 , further comprising a re-absorption system first outlet valve in communication with the re-absorption system feed side and the fluid return channel.57. The system of claim 54 , further comprising a re-absorption system second outlet valve in communication with the re-absorption system feed side and a tube in communication with a bladder or a urine collection bag.58. The system of claim 52 , ...

APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD

An apparatus for extracorporeal treatment of blood comprising a filtration unit, a blood withdrawal line, a blood return line, an effluent fluid line, a pre and/or post-dilution fluid line connected to the blood withdrawal line, and a dialysis fluid line. Pumps act on the fluid lines for regulating the flow of fluid. A control unit is configured to set initial values to one or more fluid flow rates through the above lines and to periodically execute a flow rate update procedure in order to deliver a set dose (D) in a reference time interval. 1. An apparatus for extracorporeal treatment of blood comprising:a filtration unit having a primary chamber and a secondary chamber separated by a semi-permeable membrane;a blood withdrawal line connected to an inlet of the primary chamber;a blood return line connected to an outlet of the primary chamber, said blood withdrawal line and said blood return line being configured to be connected to a patient cardiovascular system;a blood pump configured for controlling a flow of blood through the blood withdrawal line;an effluent fluid line connected to an outlet of the secondary chamber; a pre-blood pump infusion line connected to the blood withdrawal line in a region of the blood withdrawal line that is positioned upstream the blood pump, and', 'at least one of (i) a pre-dilution fluid line connected to the blood withdrawal line, and (ii) a post-dilution fluid line connected to the blood return line, and (iii) a dialysis fluid line connected to the inlet of the secondary chamber;, 'at least two fluid lines comprisingone or more pumps and/or valves for regulating the flow of fluid through the at least two fluid lines; and [{'sub': eff', 'rep', 'pbp', 'dial', 'pfr, 'calculate or receive initial set values of two or more fluid flow rates selected from the group including a fluid flow rate (Q) through the effluent line, a fluid flow rate (Q) through the pre-dilution fluid line or the post-dilution fluid line, a fluid flow rate (Q) ...

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

An extracorporeal blood treatment apparatus is provided comprising a filtration unit () connected to a blood circuit () and to a dialysate circuit (), a preparation device () for preparing and regulating the composition of the dialysis fluid; a control unit () is configured for receiving a desired sodium mass transport at the end of the treatment session and for setting the sodium concentration value for the dialysis fluid in the dialysis supply line () at a set point to achieve the desired sodium mass transport at the end of the treatment session. 118-. (canceled)19: An apparatus for extracorporeal blood treatment comprising:a filtration unit including a primary chamber and a secondary chamber separated by a semi-permeable membrane;a blood withdrawal line connected to an inlet of the primary chamber;a blood return line connected to an outlet of the primary chamber, said blood lines being configured for connection to a patient cardiovascular system;a dialysis supply line;a dialysis effluent line connected to an outlet of the secondary chamber;a preparation device for preparing a dialysis fluid connected to said supply line and including a regulator for regulating the composition of the dialysis fluid; anda control unit connected to the regulator and configured to receive a desired mass transport of a substance at the end of a treatment session and a value representative of a first parameter, the first parameter being chosen from the group consisting of a plasma conductivity, a plasma conductivity-related parameter, a concentration of the substance in the blood, a concentration-related parameter of the substance in the blood, a conductivity of the dialysis fluid, a conductivity-related parameter of the dialysis fluid, a concentration of the substance in the dialysis fluid, and a concentration-related parameter of the substance in the dialysis fluid,wherein said control unit is configured for setting a second parameter value for the dialysis fluid in the dialysis ...

BLOOD RINSEBACK SYSTEM AND METHOD

A hemodialysis system includes a dialyzer; a dialysis fluid circuit including a fresh dialysis fluid pump, and a used dialysis fluid pump; a blood circuit including a blood pump operable with an arterial line upstream of the dialyzer, a medical fluid source in fluid communication with the arterial line between a patient end of the arterial line and the blood pump, a drip chamber located along a venous line; a blood rinseback sequence wherein blood is transferred to the patient by the medical fluid, wherein the medical fluid is introduced from its source into the arterial line between an arterial line patient end and the blood pump, and flowed through the dialyzer, through the venous drip chamber along the venous line; and a blood circuit priming sequence initiated in the blood circuit via the arterial line. 1: A hemodialysis system comprising:a dialyzer; a fresh dialysis fluid pump,', 'a used dialysis fluid pump,', 'a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and', 'a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;, 'a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including'} an arterial line for removing blood from a patient and delivering the blood to the dialyzer,', 'a venous line for returning blood from the dialyzer to the patient,', 'a blood pump operable with the arterial line upstream of the dialyzer,', 'a medical fluid source in fluid communication with the arterial line between a patient end of the arterial line and the blood pump, and', 'a drip chamber located along the venous line;, 'a blood circuit in fluid communication with the dialyzer and ...

Device and method for controlling an extracorporeal blood treatment device

The invention relates to a device and a method for controlling an extracorporeal blood treatment device, in particular a haemodialysis device which has a dialyzer (1), divided by a semipermeable membrane (2) into a blood chamber (3) and a dialysis liquid chamber (4), and has a blood pump (6) for conveying blood through the blood chamber at a defined blood flow rate Qb and a dialysis liquid pump (12) for conveying dialysis liquid through the dialysis liquid chamber at a defined dialysis liquid flow rate Qd. The control device according to the invention, for a haemodialysis device, and the control method according to the invention are based on the fact that, for different blood flow rates in each case predefined during the blood treatment, the dialysis liquid flow rates are determined at which a predefined clearance or dialysance is maintained with the predefined blood flow rates and/or that, for different dialysis liquid flow rates in each case predefined during the blood treatment, the blood flow rates are determined at which the predefined clearance of dialysance is maintained. A reduction in the blood flow rate during the blood treatment, for example, leads to an increase in the dialysis liquid flow rate, such that the desired clearance is again achieved. The control device according to the invention and the control method according to the invention are also intended for a haemodiafiltration device in which, in addition to the blood and dialysis liquid flow rates, the ultrafiltration rate and the substituate rate are also taken into consideration.

A hemodialysis or hemo(dia)filtration apparatus and a method for controlling a hemodialysis or hemo(dia)filtration apparatus

System and Method for Delivery of Regional Citrate Anticoagulation to Extracorporeal Blood Circuits

The present invention includes a comprehensive replacement fluid system and method for the delivery of regional citrate anticoagulation (RCA) to extracorporeal blood circuits, wherein the system may include an online clearance monitor (OCM) and a circuit effluent online sensor system (OSS) for the continuous determination of patient plasma content of ultrafilterable solutes.

Anticoagulant-free dialysis systems and methods

An extracorporeal blood treatment system includes means for withdrawing blood from a patient, and means for transporting the blood through a calcium trap. The calcium trap includes a substrate having an immobilized species, the species being adapted to reduce the calcium concentration in the blood to a concentration that prevents blood clotting in the extracorporeal blood treatment system, thereby producing calcium-depleted blood. The extracorporeal blood treatment system also includes means for treating the calcium-depleted blood downstream of the calcium trap by an extracorporeal blood treatment device, thereby producing treated calcium- depleted blood, means for infusing calcium into the treated calcium-depleted blood downstream of the extracorporeal blood treatment device to add calcium to the treated calcium-depleted blood, and means for returning treated blood back to the patient.

High convection home hemodialysis/hemofiltration and sorbent system

A system, method and apparatus for performing a renal replacement therapy is provided. In one embodiment, two small high flux dialyzers are connected in series. A restriction is placed between the two dialyzers in the dialysate flow path. The restriction is variable and adjustable in one preferred embodiment. The restriction builds a positive pressure in the venous dialyzer, causing a high degree of intentional backfiltration. That backfiltration causes a significant flow of dialysate through the high flux venous membrane directly into the patient's blood. That backfiltered solution is subsequently ultrafiltered from the patient from the arterial dialyzer. The diffusion of dialysate into the venous filter and removal of dialysate from the arterial dialyzer causes a convective transport of toxins from the patient. Additionally, the dialysate that does not diffuse directly into the patient but instead flows across the membranes of both dialyzers provides a diffusive clearance of waste products.

Hemodialysis systems and methods

Hemodialysis dialysis systems are disclosed. Hemodialysis systems of the invention may include a dialysate flow path including a balancing circuit, a mixing circuit, and/or a directing circuit. The circuits may be defined within one or more cassettes. The fluid circuits may be at least partially isolated, spatially and/or thermally, from electrical components of the system. A gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer to urge dialysate through the dialyzer and blood back to the patient. The hemodialysis systems may include fluid handling devices, actuated using a control fluid, optionally delivered using a detachable pump. Fluid handling devices may be generally rigid and of a spheroid shape, optionally with a diaphragm dividing the device into compartments.

Dialysis systems including therapy prescription entries

A dialysis system includes a dialysis machine configured to control fluid loss or ultrafiltration (“UF”) volume over a treatment; a graphical user interface (“GUI”) that allows selection of a prescription entry for the treatment; and a processor operating with the GUI, the processor programmed to (i) receive a plurality of prescription entries via a local or wide area mode of data communication, each prescription entry including at least one prescribed parameter for operating the dialysis machine to control the fluid loss or UF volume, and (ii) enable an operator to choose between the prescription entries provided at the GUI, and select one of the prescription entries for the treatment.

An infusion apparatus

In an infusion apparatus, an infusion line (4) connects a container (2) of an infusion fluid to an extracorporeal blood circuit (23). A first valve (6) closes the infusion line downstream of an infusion pump (5). An expansion chamber (9), provided with a pressure sensor (10), is arranged between the infusion pump and the first valve. A second valve (8) closes a vent line (7) of the expansion chamber. The processor closes the first valve when the container is emptied. After replacement with a new and full container, the processor restarts the pump and selectively opens the first valve or the second valve according to the increase in pressure measured in the expansion chamber.

Fluid balancing systems and methods

Hemodialysis dialysis systems are disclosed. Hemodialysis systems of the invention may include a dialysate flow path including a balancing circuit, a mixing circuit, and/or a directing circuit. The circuits may be defined within one or more cassettes. The fluid circuits may be at least partially isolated, spatially and/or thermally, from electrical components of the system. A gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer to, urge dialysate through the dialyzer and blood back to the patient. The hemodialysis systems may include fluid handling devices actuated using a control fluid, optionally delivered using detachable pump. Fluid handling devices may be generally rigid and of a spheroid shape, optionally with a diaphragm dividing the device into compartments.

Hemodialysis systems and methods

Hemodialysis dialysis systems are disclosed. Hemodialysis systems of the invention may include a dialysate flow path including a balancing circuit, a mixing circuit, and/or a directing circuit. The circuits may be defined within one or more cassettes. The fluid circuits may be at least partially isolated, spatially and/or thermally, from electrical components of the system. A gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer to, urge dialysate through the dialyzer and blood back to the patient. The hemodialysis systems may include fluid handling devices actuated using a control fluid, optionally delivered using detachable pump. Fluid handling devices may be generally rigid and of a spheroid shape, optionally with a diaphragm dividing the device into compartments.

Blood rinseback system and method

A hemodialysis system is provided and includes a dialyzer, a dialysis fluid circuit in fluid communication with the dialyzer, a blood circuit, a blood detector and a blood rinseback scheme, wherein the blood rinseback scheme includes transferring blood to the patient using a physiologically acceptable fluid, wherein the physiologically acceptable fluid is introduced from its source into an arterial line between an arterial line patient end and a blood pump of the blood circuit, and flowed through the dialyzer, through a venous drip chamber and to the blood detector along a venous line of the blood circuit, where the physiologically acceptable fluid is sensed by the blood detector to indicate an end of the blood rinseback.

Portable dialysis machine with improved reservoir heating system

The specification discloses a portable dialysis machine having a detachable controller unit and base unit with an improved reservoir heating system. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a reservoir with an internal pan and external pan, separated by a space that holds a heating element. The heating element is electrically coupled to electrical contacts attached to the external surface of the external pan.

Priming system and method for dialysis systems

Hämo(dia)filtrationsvorrichtung mit Filtratflußsteuerung

GUEST RACE DEVICE

Blood treatment device for returning blood

Extracorporeal dialysis ready peritoneal dialysis machine

A dialysis system includes: (i) a dialysate pump; (ii) a patient line having a connector configured to be attached to a peritoneal patient part; (iii) an extracorporeal circuit; (iv) a blood pump in fluid communication with the extracorporeal circuit; (v) a blood filter in fluid communication with the extracorporeal circuit; and (vi) a control unit configured and arranged to selectively perform a therapy which (a) the blood pump is deactivated and the dialysate pump is caused to pump dialysate through the patient line or (b) the blood pump is activated to pump blood to the blood filter and the dialysate pump is caused to pump dialysate to the filter/extracorporeal circuit and/or remove fluid from the filter.

Hemo(dia) filtration apparatus

An apparatus for hemo(dia)filtration comprises an extracorporeal blood circuit and a supply line of a replacement fluid to the extracorporeal blood circuit. The supply line has a bifurcation which divides a main branch ( 24 ) into a pre-dilution branch ( 25 ) and a post-dilution branch ( 26 ). A pump tube tract ( 29 ) is predisposed in the supply line for coupling with a circuit pump of the replacement fluid. An expansion chamber is predisposed in the extracorporeal blood circuit and is fluidly connected to the pre-dilution branch. The invention provides a disposable fluid circuit usable for performing a hemodiafiltration treatment with pre-dilution and post-dilution which is couplable simply, rapidly, economically and reliably to a machine for monitoring the treatment.

Heme apparatus (day) filtration

Aparato (1 ) de 11emo(dia)filtración que comprende: un circuito de sangre extracorpóreo que tiene una linea (6) arterial y una li nea (7) venosa ; una linea (23) de suministro d. fluido de Sllslitución para el circuito de sangre extracorpóreo, teniendo dicha li nea (23) de suministro una bifurcación que divide una rama (24) principal en una rama (25) de predilución conectada en comunicación de nuido a la linea (6) arterial y una rama (26) de posdilución coneclada en comunicación de fluido a la linea (7) venosa; un tramo (29) de tubo de bomba previsto en dicha linea (23) de suministro para acoplarse con una bomba (30) para la circulación del fluido de sustitución, estando conformado dicho tramo (29) de tubo de bomba como anillo abierto con un extremo de aspiración y un extremo de entrega; y una camara (12) de expansión prevista en dicho circuito de sangre extracorpóreo; conduciendo una de dicha rama (25) de predilución y dicha rama (26) de posdiluci6n a dicina cámara (12) de expansión; caracterizado porque dicho extremo de aspiración y dicho extremo de entrega están conectados rl gidamente a dicha cámara (12) de expansión; y porqu e el aparato comprende además: un elemento (35, 36) de soporte al que está sujeta dicha linea (23) de suministro para que dicha rama (25) de predilución y dicha rama (26) de posdllución estén situadas en una posición predetermin ada con !'especto a dicha cámara (12) de expansión, y un módulo que comprende dicha linea (23) de suministro, dicho tramo (29) de tubo de bomba, dicha cámara (12) de expansión y dicho elemento (35, 36) de soporte, en el que dicha rama (25) de predilución y dicha rama (26) de posdlluclón comprenden cada llna al menos un Iramo de tubo compresible, estando situados dichos tramos de tubo compresibles en una posición prefijada con respecto a dicha camara (12) de expansión. Apparatus (1) of 11emo (day) filtration comprising: an extracorporeal blood circuit having an arterial line (6) and a venous line (7); a supply ...

Method for returning blood from a blood treatment device, and device for carrying out this method

The invention relates to a method for the return of blood from a blood treatment apparatus, preferably from a dialysis apparatus. In accordance with the invention, the substituate pump contained in the treatment apparatus displaces the blood by means of correspondingly transported substituate fluid until it is detected in corresponding detectors that substituate fluid is flowing back in the line instead of blood. From this moment in time, the blood volume is further displaced in a controlled manner until it has reached the line outlet of the corresponding line.

Gas separation devices

A description is given of a gas separation device for a physiological fluid, comprising a containing body ( 6 ) having at least a first inlet aperture ( 7 ) for a physiological fluid, positioned with a tangential direction of access, at least one outlet aperture ( 9 ) for the said fluid, spaced apart from the said inlet aperture, and a guide element ( 17 ) housed within the said body. The guide element ( 17 ) has a continuous active surface ( 15 ) designed to contact and guide the said fluid and delimits, together with the containing body ( 6 ), a first annular chamber ( 20 ) into which the first inlet aperture ( 7 ) opens directly.

Device and method for controlling the balance of fluids on an extracorporeal blood circuit.

Hot water disinfection of dialysis machines, including the extracorporeal circuit thereof

A dialysis machine is disclosed that incorporates a water treatment module, a dialysate preparation module having a dialysate circuit, and an extracorporeal circuit including a dialyzer and arterial and venous blood lines that connect to the patient. The machine accomplishes on-line disinfection of all the fluid circuits of the machine, including the water treatment module, the dialysate preparation module and extracorporeal circuit, the arterial and venous lines, and the dialyzer, by circulating water heated to a high level disinfection temperature (e.g., 80 degrees C.) through the fluid passages of the machine for a sufficient time (such as an hour) to achieve high level disinfection. After the dialysis session is ended, the patient connects the arterial and venous lines to ports in a disinfection manifold that places the arterial and venous lines into fluid communication with the heated water. Thereafter, the machine is ready to disinfect the fluid circuits including the extracorporeal circuit. In a preferred embodiment, the ports of the disinfection manifold ports include recessed features that permit the hot water to circulate on the interior and exterior surfaces of the arterial and venous line connectors, thereby insuring that the surfaces of connectors themselves are also disinfected.

Method and device for monitoring the supply of substitution fluid during extracorporeal blood treatment

Verfahren zur Überwachung der Zufuhr von Substitutionsflüssigkeit für eine Vorrichtung zur extrakorporalen Blutbehandlung mit einem extrakorporalen Blutkreislauf, der eine erste Kammer eines durch eine Membran in die erste Kammer und eine zweite Kammer unterteilten Dialysators oder Filters einschließt, und einem Flüssigkeitssystem, das die zweite Kammer des Dialysators oder Filters einschließt, wobei Substitutionsflüssigkeit stromauf oder stromab des Dialysators oder Filters mit einer Substituatpumpe zugeführt wird, dadurch gekennzeichnet, dass für die Detektion der Zufuhr von Substitutionsflüssigkeit die abgeschaltete Substituatpumpe eingeschaltet und/oder die eingeschaltete Substituatpumpe abgeschaltet wird und der Druck im extrakorporalen Blutkreislauf stromab des Dialysators oder Filters gemessen wird, wobei eine Zufuhr von Substitutionsflüssigkeit stromauf oder stromab des Dialysators oder Filters auf der Grundlage der Veränderung des Drucks nach dem Abschalten und/oder Einschalten der Substituatpumpe erkannt wird. method for monitoring the supply of substitution fluid for one Device for extracorporeal blood treatment with an extracorporeal blood circulation, a first chamber through a membrane in the first chamber and a second chamber includes a divided dialyzer or filter, and a fluid system, which includes the second chamber of the dialyzer or filter, wherein Substitution fluid upstream or downstream of the dialyzer or filter with a substituate pump supplied is characterized in that for the detection of the supply of substitution fluid switched off Substituatpumpe switched on and / or switched on Substituatpumpe is switched off and the pressure in the extracorporeal Blood circulation is measured downstream of the dialyzer or filter, wherein a supply of substitution liquid upstream or downstream of the Dialyzers or filters based on the change the pressure after switching off and / or switching on the Substituatpumpe is recognized.

Blood purification system

Disclosed is a blood purification system comprising a blood purification circuit and a blood purification device, which can control the amount of water to be removed from or fed to a patient having a kidney disease or multi organ failure more accurately in the treatment of the patient, is easy to be set-up, and is particularly suitable for use in a continuous hemofiltration method. Specifically disclosed is a blood purification system comprising a blood purification circuit and a blood purification device, in which flexible tubes for flow paths (14, 15, 33, 34, 53) which connect a first flat panel (1) to a second flat panel (2) and the positioning of the flexible tubes are so selected as to satisfy the predetermined requirement represented by a specific formula.

Medical fluid therapy flow control systems and methods

Systems and methods for improving medical fluid delivery systems, such as hemofiltration (“HF”) and hemodiafiltration (“HDF”) are provided. In first embodiments, systems and methods for selectively performing pre- and postdilution HF and HDF clearance modes is provided. In other embodiments, systems and methods for providing prime bolus and rinseback fluid volumes before, during and/or after HF and HDF therapies are provided. In further embodiments, improved systems and methods for removing ultrafiltrate from the patient are provided. Still further, improved filtration configurations and methods are provided.

Method of priming dialyzer

A method is described for priming a dialyzer placed in an extracorporeal circuit of a hemodialysis machine in situ. The method comprises the steps of substantially filling the extracorporeal circuit and the blood side of the dialyzer with fluid (such as dialysate, RO water, saline, etc.), and inducing pressure pulses in the fluid. The pressure pulses cause air bubbles from the blood side of the dialyzer to be sheared off the dialyzer membrane. The air bubbles are then conducted from the dialyzer and removed from the extracorporeal circuit. Backfiltering of fluid across the dialyzer from the dialysate circuit into the extracorporeal circuit is performed in synchrony with the pressure pulses to assist in the shearing off of air bubbles from the blood side of the dialyzer membrane.

Batch dialysate chemical vessel with machine-readable indicator

A vessel storing a batch of chemicals for delivery into a dialysate preparation tank includes a machine readable indicator, permitting automatic identification of the contents of the vessel prior to operating the vessel and introduction of chemicals into a tank where the dialysate solution is mixed. Various types of machine-readable indicators may be used, such as, for example, "touch" memory buttons, bar codes, or magnetic strips. Suitable reading devices for the machine-readable indicators are provided for reading the contents of the bottle.

Apparatus for opening a vessel

An apparatus is described for automatically opening and dispensing the contents of a vessel, for example, a vessel containing dialysate chemicals for dispersion into a dialysate preparation tank. The apparatus comprises a housing having an open interior region, with the vessel mounted above the housing, and a spike reciprocable within the interior of the housing between upper and lower positions. The spike pierces the vessel when the spike is moved to the upper position. The spike has an upper spike element that pierces the bottle and an integral spike body concentric with the housing permitting passage of dialysate chemicals therethrough after the spike has pierced the vessel. A drive means is proved for moving the spike relative to the housing between the upper and lower positions, so as to control the operation of the spike and the automatic release of the contents of the vessel.

Dialysate separation method

A method for maintaining separation of old and new dialysate in a dialysate preparation tank is disclosed. The new dialysate is stored in the tank at a first temperature and withdrawn from the bottom of the tank. The dialysate is circulated through a dialyzer, and then returned to the tank at the top of the tank at a higher temperature in a substantially non-turbulent manner. The temperature differential between old and new dialysate and the manner of withdrawing and reintroducing the dialysate to the tank cooperate to form discrete zones of old and new dialysate without substantial mixing of the dialysate in the two zones.

Tubing connectors and parts for receiving the connectors

A connector for a tube and a port construction for sealingly and securely receiving the connector. The connector has a male luer comprising a locking hub and a cylindrical tubing port. The cylindrical tubing port receives the free end of the tube. A second piece is provided that envelops the male luer, comprising a elongate cylindrical housing having a interior surface. The male luer and the tube are snugly inserted within the interior surface of the second piece to form a unitary connector. The port receives the connector and has a housing having a first end and a second end and an open interior region defining first and second chambers and a housing axis. The first and second chambers are disposed within the first and second ends of the housing, respectively. A locking knob is movably mounted on the first end of the port apparatus and movable along the housing axis relative to the first end between first and second positions. The knob is rotatable in the second position relative to the first end into a locking engagement with the housing. When the connector is inserted into the first chamber of the port, the user rotates the knob to one side to securely retain the connector. The connector is pressed into sealing contact with an O-ring disposed in the interior region of the first chamber, thereby preventing any leakage around the connector and port. Various alternative tubing connectors are disclosed.

Method for detection of leakage of blood

A method for detecting the presence of blood in a dialysate solution is disclosed. The method provides for certain measurement of light intensity passing through solutions both before and during the dialysis session. Before dialysis is commenced, measurements are made of the intensity of light passing through a chamber containing a control dialysate solution that is free of blood. The light source is a first condition. The light source's state is changed from a first condition to a second condition different from the first condition. Next, a second measurement of the intensity of light is made. The first and second measurements are stored. During dialysis, the method continues with the following steps: conducting a third measurement of the intensity of light of the light source that passes though the chamber, the chamber containing dialysate solution that may contain the patient's blood, with the light source in the first condition. Next, the state of the light source is changed from the first condition to the second condition. A fourth measurement of the intensity of light passing through the solution is made. A suitable processor calculates an attenuation coefficient indicative of the presence of blood in the dialysate solution during dialysis from the first, second, third and fourth measurements.

Filter integrity test method for dialysis machines

A method is described for automatically testing the integrity of a dialyzer filter within a dialysis machine. The method consists of substantially removing fluids which may be present from the blood side of the dialyzer filter, pumping air into the blood side of the dialyzer filter with a blood pump to pressurize the dialyzer filter, and measuring the pressurization of the dialyzer filter. If the dialyzer filter pressurizes, the rate of decay of pressurization is measured. The pressurization and rate of decay are indicative of the integrity of the membrane of the dialyzer filter.

Disinfection of arterial and venous line connectors hemodialysis machine

A hemodialysis machine has ports of a disinfection manifold for receiving the arterial and venous line connectors terminating the arterial and venous lines. The ports are in fluid communication with a hydraulic system that circulates disinfection fluid through the machine including the extracorporeal circuit. The ports are constructed so as to provide a gap extending circumferentially around the arterial and venous line connectors. When the disinfection fluid circulates through the ports of the disinfection manifold, the fluid circulates around the external surfaces of the connectors as well as through the internal fluid passages, thereby insuring a complete disinfection of the connectors.

Dialysis machine with leakage detection

A dialysis machine is described which provides for the detection of leakage anywhere in the machine. The machine includes integral water treatment, dialysate preparation and extracorporeal circuit modules. The floor of the machine is constructed in a non-horizontal manner so as to provide a fluid catchment chamber with a fluid sensor. The extracorporeal circuit is mounted above the dialysate preparation module and the water treatment module. In one embodiment, a drain and drain tube allows fluid that leaks from the extracorporeal circuit module to be conducted to the floor of the machine, where the leak can be detected, along with a fluid leak in the water treatment or dialysate preparation modules. In another embodiment, a separate fluid leakage detector is placed at the base of the extracorporeal circuit module for detection of leakage in situ in the extracorporeal circuit, while the catchment chamber and sensor in the base of the machine detect leaks from the other modules.

Apparatus for supplying a batch of chemicals to a dialysate tank

A loading platform and chemical addition system are described for a machine that prepares a batch of dialysate. The loading platform is in fluid communication with a dialysate preparation tank, and receives chemical vessels that contain a batch quantity of dialysate chemicals. The chemicals are released from the vessels automatically and fall onto a shelf in the loading platform. Nozzles and spray equipment are provided for insuring the complete release of the chemicals from the vessels and their dispersion into the tank. Novel mixing techniques are implemented in the tank to insure complete mixing of the dialysate solution and prevention of settling of dialysate solution at the bottom of the tank.

Method of rinsing back blood to hemodialysis patient

A method is described herein for automatically rinsing blood back to a patient. The method comprises the steps of pumping dialysate (or, alternatively, saline solution) through a dialyzer into an extracorporeal circuit, and pumping blood in the extracorporeal circuit out the arterial and venous lines back to the patient. Optical sensors monitor the concentration of blood in the arterial and venous lines as the blood is being pumped from the extracorporeal circuit back to the patient. The return flow of blood is ceased when the concentration of blood in the arterial and venous lines drops to a predetermined threshold level, thereby preventing excess fluids from being returned to the patient.

Methods for ultrafiltration control in hemodialysis

Methods and apparatus for increasing the accuracy of ultrafiltration in a dialysis machine and decreasing the time required for dialysis. The machine inclused a substantially non-compliant tank for mixing and storing a batch of dialsyate. In a preferred form, the tank is a hollow vessel made from a lightweight and chemically inert material, such as polypropylene, reinforced on its exterior. The machine further includes an ultrafiltration pump for pumping fluid from an extracorporeal circuit to an ultrafiltration tank commensurate with the removal of water from the patient. The pump is calibrated with the volume of fluid in the tank. The reduction in the time to conduct hemodialysis of the patient is achieved by introducing the patient's blood into the arterial line and conducting the blood to the blood pump, measuring the pressure of the blood in the arterial line, increasing the pump rate of the blood pump, and in the event that the pressure measured in the arterial line drops below a predetermined threshold value, slowing the pump rate of the blood pump.