Vorrichtung und Verfahren zur Durchführung einer Blutplasmapherese.

Die Erfindung betrifft eine Vorrichtung zur Durchführung einer Blutplasmapherese, umfassend eine Blutpumpe (1), einen Plasmafilter (2), eine Plasmapumpe (7), einen Kaskadenfilter (10), einen Sammelbehälter (12) sowie einen Sensor (17). Es ist eine Rezirkulationsleitung (19) vorgesehen, die eine Verbindung zwischen der das Blutplasma oder Filtrat führenden Leitung in Fließrichtung hinter dem Kaskadenfilter (10) mit der das Blutplasma führenden Leitung in Fließrichtung vor dem Kaskadenfilter (10) bildet. Die Erfindung betrifft zudem ein Verfahren zur Durchführung einer Blutplasmapherese.

체외 혈액 치료를 위한 시스템 및 방법

... 본원은 대상체를 치료하기 위한 체외 혈액 치료 시스템(50)에 관한 것으로, 상기 시스템은 체외 혈액 회로(52); 투석액 유체 회로(54); 혈액 회로를 통한 혈액의 흐름을 제어하기 위한 적어도 하나의 혈액 펌프(60); 투석액 유체 회로(54)를 통한 투석액 유체의 흐름을 제어하기 위한 적어도 하나의 투석액 유체 펌프(62); 혈액 펌프 및 투석액 유체 펌프에 작동 가능하게 연결된 시스템 컴퓨팅 유닛(64)으로서, 상기 시스템 컴퓨팅 유닛은 적어도 하나의 입력 수단을 갖는 시스템 컴퓨팅 유닛을 포함하며, 상기 체외 혈액 회로 및 투석액 유체 회로는 여과 유닛(58)의 막(56)에 의해 나누어지며; 상기 시스템 컴퓨팅 유닛은 글루타민의 소정 혈중 농도 GLNb를 수신하고, 글루코스의 소정 혈중 농도 GLUCOSEb를 수신하고, 케톤체 KETONEb의 소정 혈중 농도를 수신하도록 되어 있고; 시스템 컴퓨팅 유닛은 글루타민의 실제 농도 값 GLNa가 GLNb를 향해 유도되고 글루코스의 실제 농도 값 GLUCOSEa가 Db를 향해 유도되고 케톤체의 실제 농도 값이 KETONEa를 향해 유도되도록 상기 혈액 펌프 및 상기 투석액 유체 펌프를 제어하도록 되어 있는 체외 혈액 치료 시스템(50)에 관한 것이다. 본원은 또한 체외 혈액 치료 시스템에서 사용하기 위한 요법 세트, 시스템을 사용하여 암을 치료하는 방법, 상기 방법을 제어하기 위한 제어기뿐만 아니라, 상기 방법에 적절한 투석액에 관한 것이다.

ARTIFICIAL LUNG DEVICE

An artificial lung device comprising: a housing (1002, 1102, 1202, 1302, 1402, 1502, 1602, 1702) including a blood inflow port (1016, 1316, 1416, 1516, 1616, 1716) and a blood outflow port (1017, 1317, 1417, 1517, 1617, 1717); a gas exchanger (1021, 1121, 1221, 1321, 1421, 1521, 1621, 1721) arranged in the housing and configured to perform gas exchange with respect to blood while the blood flows from the blood inflow port to the blood outflow port; and a guide surface (1031, 1110b, 1267a, 1334a, 1491, 1591, 1634, 1767, 1768, 1031B) arranged so as to be opposed to a surface of the gas exchanger and forming a space (1091, 1191, 1291, 1391, 1472, 1574a, 1691, 1791A, 1791B, 1091B) between the guide surface and the surface of the gas exchanger, wherein the surface of the gas exchanger and the guide surface form a bubble guide portion (1090, 1190, 1290, 1390, 1490, 1590, 1690, 1790A, 1790B) by which bubbles having flowed through the gas exchanger are guided to the gas exchanger again; and a separation ...

МЕМБРАННЫЙ ОКСИГЕНАТОР

Изобретение относится к медицинской технике, а именно к мембранному оксигенатору. Оксигенатор содержит верхнюю крышку, которая последовательно разделена на первое пространство кровеносного тракта, первое пространство воздушного тракта и первое пространство водного тракта от центра к внешнему краю. Верхняя крышка снабжена впускным отверстием для газа, соединенным с первым пространством воздушного тракта, первым выпускным отверстием для газа, соединенным с первым пространством кровеносного тракта, и впускным отверстием для воды, соединенным с первым пространством водного тракта. Оксигенатор имеет нижнюю крышку, которая последовательно разделена на второе пространство кровеносного тракта, второе пространство воздушного тракта и второе пространство водного тракта от центра к внешнему краю. Нижняя крышка снабжена выпускным отверстием для крови, соединенным со вторым пространством кровеносного тракта, выпускным отверстием для воздуха, соединенным со вторым пространством воздушного тракта, и выпускным ...

Heater/cooler for an oxygenator

The present disclosure relates to a system for extracorporeal blood circulation, including an oxygenator which includes a heat exchanger configured for warming or cooling blood in extracorporeal blood circulation of a patient, and a heater/cooler configured for exchanging a quantity of heat with the heat exchanger, wherein the heater/cooler includes an thermoelectric heater/cooler and wherein the heater/cooler (14) is connected to the heat exchanger (11) by a thermal connecting element (15).

ARTIFICIAL LUNG

Устройство для мониторинга показателей газовой смеси аппарата экстракорпорального кровообращения

Предлагаемая полезная модель относится к медицине, в частности к сердечно-сосудистой хирургии, патофизиологии, перфузиологии, и может быть использована при экстракорпоральном кровообращении (ЭК) для мониторинга показателей: процентной концентрации углекислого газа, конечно-экспираторного парциального напряжения углекислого газа (РЕТСО2), продукции углекислого газа (VCO2), основного обмена пациента (REE), объемного расхода газовой смеси (Qv), потребления кислорода (VO2), концентрации анестетиков (севорана, изофлюрана, фторотана). Получение этих данных в реальном времени является необходимым условием для поддержания показателей газообмена и метаболизма пациентов в физиологических границах, при операциях на сердце в условиях экстракорпорального кровообращения или проведения экстракорпоральной мембранной оксигенации (ЭКМО). Устройство состоит из последовательно соединенных прозрачной магистралью дюйма миксера газов и испарителя анестетиков аппарата экстракорпорального кровообращения, датчика ...

BLOOD CIRCUIT ASSEMBLY FOR A HEMODIALYSIS SYSTEM

A blood circuit assembly for a dialysis unit may include an organizing tray, a pair of pneumatic pumps mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient, an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit, a pair of dialyzer connections arranged to connect to the inlet and outlet of a dialyzer unit, and a pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient.

INJECTION CANNULA, ECMO SYSTEM

SYSTEMS AND METHODS FOR UPDATING BLOOD SEPARATION CONTROL PARAMETERS USING BLOOD AND/OR BLOOD SOURCE CHARACTERISTICS

Systems and methods are provided for determining and controlling the location of an interface between separated blood components within a centrifuge. An optical monitoring assembly is used to determine the position of the interface, with the current position being compared to a target position. An error signal, which is indicative of the distance between the two positions, is input into a proportional-integral-derivative control algorithm to generate a control signal. The control signal is used to modify the rate at which a separated blood component is removed from the centrifuge so as to move the interface toward the target position. Blood characteristics, blood source characteristics, and/or the rate at which blood is pumped into the centrifuge are monitored for any changes, with a change in one or more of these factors being used to modify the control algorithm.

WEARABLE MODULAR EXTRACORPOREAL LIFE SUPPORT DEVICE FOR MOBILE TREATMENT OF SINGLE AND MULTIORGAN FAILURE

In one exemplary embodiment, a wearable extracorporeal life support device includes a catheter fluidly connected to a pump and first and second modular extracorporeal life support components. The device may also be configured to be attached to a garment. The pump and the first and second modular extracorporeal life support components may be fluidly connected in series. The pump and the first and second modular extracorporeal life support components may also be fluidly connected in parallel. The first modular extracorporeal life support component may be a lung membrane and the second modular extracorporeal life support component may be a dialysis membrane.

Fluid sampling or infusion device for an extracorporeal blood treatment apparatus

A fluid sampling or infusion device for an extracorporeal blood treatment apparatus comprises: a protective body (29) having a first aperture (30) and a second aperture (31) and comprising a connecting device (28) configured to connect, optionally in removable manner, the protective body (29) to a sampling or infusion site (20) of the extracorporeal blood treatment apparatus (1); a needle assembly (33) comprising a first end (34) connected or connectable, optionally in removable manner, to a syringe (22) and a needle (35) protruding from a second end opposite the first end (34). The needle assembly (33) is movable inside the protective body (29) between a first position and a second position. In the first position the needle (35) is completely enclosed by the protective body (29) and in the second position the needle (35) protrudes from the second aperture (31) to pierce the sampling or infusion site (20).

Parameter Monitoring in Medical Treatment Systems

A blood treatment system with pressure sensors may be configured to control blood flow to and from the patient and use readings of the pressure sensors to determine a change in a pressure drop across a flow restriction in the blood circuit to estimate a condition of the machine or the patient, or outputting data responsive to the estimation. Further embodiments employ measurement of pressure drop to detect abnormal viscosity or viscosity variations in order to detect possible infection.

ULTRA LOW-LEAKAGE SILICONE-BASED HEATER THERMALLY COUPLED TO HEAT TRANSFER BODY

Systems and methods include a heat transfer body with opposing major surfaces formed from a thermally conductive substrate in intimate thermal interaction with an alumina exterior surface that extends across the major surfaces of the body. In an illustrative example, the heat source may be a substantially planar, silicone-based heater source (P-SBHS). The heat transfer body may be configured to thermally interact, for example, heat from a heat source proximate a first of the major surfaces to a second of the major surfaces. A temperature sensor module may be located, for example, proximate to the first major surface such that a temperature sensor thermally interacts with the first major surface. The temperature sensor module may, for example, insulate the temperature sensor from the P-SBHS.

HEMODIALYSIS SYSTEMS

A hemodialysis system comprising a blood flow path, a first cassette defining an inner dialysate fluid path, a dialyzer in fluid communication with the blood flow path and the inner dialysate fluid path, a second cassette defining an outer dialysate fluid path, a filter fluidly connecting the first cassette to the second cassette, and at least one pod fluidly connecting the first cassette and the second cassette.

ARTIFICIAL LUNG AND METHOD FOR PRODUCING SAME

METHOD FOR MANUFACTURING HEAT EXCHANGER AND HEAT EXCHANGER

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

Oxygenator

An oxygenator includes: a housing; a bubble-removing hollow fiber membrane layer removing a bubble; a gas-exchanging hollow fiber membrane layer exchanging a gas with blood; and a discharge port to discharge the bubble removed by the bubble-removing hollow fiber membrane layer to the outside of the housing. The oxygenator further includes a gas permeable portion that is arranged between the discharge port and an end portion of the bubble-removing hollow fiber membrane layer, is formed by a member having gas permeability, and allows passage of the bubble removed by the bubble-removing hollow fiber membrane layer without allowing passage of plasma leaking through the bubble-removing hollow fiber membrane layer. A plasma capture chamber that captures the plasma leaking through the bubble-removing hollow fiber membrane layer is formed between the end portion of the bubble-removing hollow fiber membrane layer and the gas permeable portion.

HEAT EXCHANGER AND ARTIFICIAL LUNG

Microfluidic removal of excess bilirubin from blood

A microfluidic photoreactor for treating excess bilirubin in blood, having: a microfluidic channel module; an illumination module comprising one or more illumination sources disposed about the microfluidic channel module and configured to illuminate blood passing through at least one microfluidic channel of the microfluidic channel module; and a heat exchanger module coupled to the at least one microfluidic channel module, wherein the heat exchanger module is configured to extract heat from the at least one microfluidic channel. A system including a microfluidic photoreactor and a method of treating excess bilirubin in blood.

SYSTEM FOR REDUCING GASEOUS MICROEMBOLI USING VENOUS BLOOD BYPASS WITH FILTER

APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD AND METHOD OF PRIMING AN EXTRACORPOREAL BLOOD CIRCUIT

An extracorporeal blood treatment apparatus comprises: a blood treatment device (2); an extracorporeal blood circuit comprising a blood withdrawal line (6) and a blood return line (7) coupled to the extracorporeal blood treatment device (2), wherein the blood return line (7) presents a heating zone (14) coupled or configured to be coupled to a blood warmer (15); a blood pump (6) configured to be coupled to a pump section of the blood withdrawal line (6); at least a post-infusion line (13, 13') connected to the blood return line (7) upstream of the heating zone (14); an air trapping device (9) placed on the blood return line (7) upstream of the heating zone (14).

OXYGENATOR WITH THERMAL INSULATION

An oxygenator includes a housing having a blood inlet and a blood outlet, the blood inlet extending into an interior of the housing. A heat exchanger is disposed within the housing, and is coupled, at an inlet end, to a heat-exchange fluid inlet. A gas exchanger also is disposed within the housing, and includes a bundle of gas-exchange fibers coupled, at a gas outlet end, to a gas-exchange fluid outlet. The oxygenator includes at least one insulator configured to thermally insulate at least the gas outlet end of the bundle of gas-exchange fibers.

EQUIPMENT FOR THE CONTROL OF BIOMEDICAL DEVICES DURING EXTRACORPOREAL CIRCULATION AND RELATED SYSTEM

Connector assembly and methods of use

Connector assemblies and methods of replacing components in an extra-corporeal circuit (ECC) system are disclosed. A connector assembly for use in an ECC system includes a tubular body having an inner surface defining a lumen extending through the tubular body with the lumen extending along a longitudinal axis, a first connection interface in fluid communication with the lumen, a second connection interface in fluid communication with the lumen, and a plurality of closure mechanisms, each closure mechanism being configured to occlude the lumen.

BLOOD PROCESSING UNIT (BPU) WITH COUNTERCURRENT BLOOD/WATER FLOW PATHS IN THE HEAT EXCHANGER (HEX)

Described is a blood processing apparatus with a blood flow path and a heat exchanger fluid flow path overlapping the a heat exchanger chamber, in which the blood flows generally from a first end to a second end of the blood processing apparatus, and the heat exchanger fluid flows generally from the second end to the first end. Such “counter” or “countercurrent” flow improves heat transfer between the blood and the heat exchanger fluid. The blood processing apparatus includes a housing, a blood inlet, a heat exchanger fluid inlet and a heat exchanger fluid outlet, a heat exchanger core, a cylindrical shell having an annular shell aperture, a blood flow distributor, and a central chamber in fluid communication to a fluid flow distributor.

Modular heater cooler with disposable heat transfer fluid circuit

A system (20) including a heater/cooler module (22) to heat/cool a first fluid in a primary circuit (28), a heat transfer fluid circuit (24) to provide a second fluid to a target device (38) to heat/cool the target device (38), and a heat exchanger (26) including at least part of the primary circuit (28) and at least part of a secondary circuit (36) through which the second fluid flows to facilitate heat transfer between the first fluid and the second fluid. The primary circuit (28) and the secondary circuit (36) are separate circuits and the first fluid and the second fluid remain separated in the system. Also, the system is modular, such that the elements can be stacked to increase heating/cooling capability and/or to increase the number of heating/cooling channels, and the system is compatible with portable applications, such as ambulance, aircraft, and helicopter applications, and with battery operation and/or the use of uninterruptible power supplies.

PHOTODYNAMIC THERAPY DEVICE COMPRISING COOLING WATER CIRCULATION UNIT FOR BLOOD

The photodynamic therapy device of the present disclosure is a photodynamic therapy device that irradiates light from a light source onto blood that has been taken out of a patient's body and is flowing in the blood tube, the blood having absorbed a photoreactive agent, to destroy an undesirable component in the blood or affect the component. The photodynamic therapy device includes the irradiation unit that includes a light source and irradiates the blood in the blood tube with light, and the circuit cooling block that cools the blood in the blood tube. The circuit cooling block is connected to the pump that circulates cooling water in the circuit cooling block, the reservoir tank, and the cooling unit that cools water by the water flow path for flowing the cooling water.

SYSTEMS, ASSEMBLIES, AND METHODS OF TRAUMA MANAGEMENT

A system for performing extracorporeal blood treatment of recovered blood can include a reservoir to receive a first portion of the recovered blood from a subject, an inline pump coupled the reservoir to regulate a flow rate of at least the first portion of the recovered blood, and an extracorporeal blood conditioner including at least one of an oxygenator to reoxygenate hemoglobin included in the recovered blood for at least intravenous delivery back to the subject or a temperature regulator configured to selectively control a temperature of the recovered blood.

CONTAINER FOR FLUIDS AND APPARATUS FOR TEMPERATURE CONTROL, E.G. WARMING, OF MEDICAL FLUIDS

A container for warming fluids comprises an inlet port, an outlet port, a fluid conduit configured for fluidly communicating the inlet and outlet ports, and deflection sections. The fluid conduit has a non-constant maximum width in a direction of fluid flow through the fluid conduit. The deflection sections further comprise an entry section and an exit section, each respective exit section being arranged downstream, in the direction of fluid flow, from each respective entry section. The maximum width of the fluid conduit decreases along the direction of fluid flow through the entry section over a first distance and the maximum width of the fluid conduit increases along the direction of fluid flow through the exit section over a second, different distance. A blood treatment apparatus including the above-described container is also provided.

ARTIFICIAL LUNG DEVICE

An artificial lung device comprising: a tubular housing (3002) including both ends that are closed; a heat exchanger (3061) provided in the housing and configured to perform heat exchange with respect to blood; a gas exchanger (3045) arranged around an axial direction of the heat exchanger in the housing and configured to be in fluid communication with the heat exchanger and perform gas exchange with respect to the blood; a blood inflow port (3016) provided at a first end side of the housing and configured to be in fluid communication with the heat exchanger; and a blood outflow port (3017) provided at the housing and configured to be in fluid communication with the gas exchanger, wherein the artificial lung device further comprises: a heat medium partial chamber (3035) which is arranged between the heat exchanger and the gas exchanger and around the axial direction of the heat exchanger and through which a heat medium flowing in and out from the heat exchanger flows; a medium inflow port ...

Blood processing unit (BPU) with countercurrent blood/water flow paths in the heat exchanger (HEX)

Described is a blood processing apparatus with a blood flow path and a heat exchanger fluid flow path overlapping the a heat exchanger chamber, in which the blood flows generally from a first end to a second end of the blood processing apparatus, and the heat exchanger fluid flows generally from the second end to the first end. Such “counter” or “countercurrent” flow improves heat transfer between the blood and the heat exchanger fluid. The blood processing apparatus includes a housing, a blood inlet, a heat exchanger fluid inlet and a heat exchanger fluid outlet, a heat exchanger core, a cylindrical shell having an annular shell aperture, a blood flow distributor, and a central chamber in fluid communication to a fluid flow distributor.

PARAMETER MONITORING IN MEDICAL TREATMENT SYSTEMS

Hollow fiber membrane-type artificial lung

The present invention provides a hollow fiber membrane oxygenator comprising a housing comprising a blood flow path; a blood inlet port and a blood outlet port disposed in the housing so as to allow blood to flow through the blood flow path; a gas exchange part comprising a bundle of a plurality of hollow fiber membranes disposed in the blood flow path, a gas inflow port and a gas outflow port provided in the housing so as to allow an oxygen-containing gas to flow through lumens of the hollow fiber membranes, and a gas temperature control part for adjusting the temperature of a gas flowing through the lumens of the hollow fiber membranes.

Multiple mode treatment devices methods and systems

A blood treatment system employing at least two pumps for performing a low blood flow treatment is operable for high blood flow treatments such as extracorporeal membrane oxygenation (ECMO) by providing a fluid circuit with parallel blood flow paths and recruiting multiple ones of the pumps for parallel blood flow.

Extracorporeal blood treatment apparatus and method for monitoring pressures in an extracorporeal blood treatment apparatus

An extracorporeal blood treatment apparatus, comprises: at least a pressure sensor (24, 25) located in a respective measurement site on an extracorporeal blood circuit (6, 7); an electronic control unit (23) operatively connected at least to the pressure sensor (24, 25). The electronic control unit (23) is configured to perform at least the following procedure: receiving from the pressure sensor (24, 25) a signal correlated to a measured blood pressure (P1measured, P2measured) in the measurement site; correcting the blood measured pressure (P1measured, P2measured) through a mathematical correction model to obtain a blood actual pressure (Pinlet, Poutlet) in a reference site other than the measurement site. Between the reference site and the measurement site, a circuit section and, optionally, at least one additional device (18, 27, 28) is/are positioned. The mathematical correction model is a model of a pressure drop in the circuit section and, optionally, in the additional device (18, ...

ARTIFICIAL LUNG DEVICE

An artificial lung device comprising: a housing (2) formed in a tubular shape including both end portions that are closed, the housing including a blood inflow port (16) and a blood outflow port (17) and arranged such that a center axis of the housing is directed in a lateral direction; a gas exchanger (43) arranged in the housing and configured to perform gas exchange with respect to blood while the blood flows from the blood inflow port to the blood outflow port; a filter structure (56, 66) provided around the gas exchanger; and a bubble storing portion (70) provided between the filter structure and the gas exchanger, wherein the bubble storing portion is located at an upper side of the housing and faces the gas exchanger.

EXTRACORPOREAL LIFE SUPPORT SYSTEM

An extracorporeal blood treatment system may include a clamp coupled to a blood pathway extending between a patient and a reservoir, a sensor positioned along the blood pathway, and a control unit in communication with both the clamp and the sensor. The sensor is configured to sense a parameter of blood passing through the blood pathway and the sensor is configured to transmit a signal corresponding to the parameter to the control unit. The control unit is configured to receive the signal and transmit a signal to the clamp. The clamp is configured to receive the signal from the control unit and controllably adjust blood flow through the blood pathway in response to receiving the signal from the control unit.

EXTRACORPOREAL BLOOD HEATING AND COOLING SYSTEM AND METHOD OF MAINTAINING SAME

SYSTEM FOR DETECTING REPLACEMENT OF BLOOD BY DIALYSATE SOLUTION

Parameter monitoring in medical treatment systems

A blood treatment system with pressure sensors may be configured to control blood flow to and from the patient and use readings of the pressure sensors to determine a change in a pressure drop across a flow restriction in the blood circuit to estimate a condition of the machine or the patient, or outputting data responsive to the estimation. Further embodiments employ measurement of pressure drop to detect abnormal viscosity or viscosity variations in order to detect possible infection.

SYSTEM FOR REDUCING GASEOUS MICROEMBOLI USING VENOUS BLOOD BYPASS WITH FILTER

A system and method for reducing gas bubbles, including gaseous microemboli (GME) during cardiopulmonary bypass (CPB) by the use of an oxygenator with venous blood bypass and a filter in the venous blood bypass is provided.

HEMODIALYSIS SYSTEMS

A cassette assembly comprising a blood flow path through which blood is drawn from a patient and passed through a dialyzer. The blood flow path includes a blood flow pump. The cassette assembly comprises at least two cassettes. The assembly also comprises a dialysate flow path through which dialysate flows from a dialysate supply through the dialyzer. The dialysate flow path includes a dialysate pump. The dialysate flow path is defined by the at least two cassettes that are immobilized relative to each other. The assembly further comprises a pod pump connectable between the two cassettes, and a control fluid path through which a control fluid actuates the blood flow pump and the dialysate pump.

Apparatus for extracorporeal blood treatment

An apparatus (1) for CRRT is provided comprising a blood circuit (10, 20, 30, 60) with a blood removal line (20), a treatment unit (10), and a blood return line (30). A replacement fluid container (78) is configured for containing a medical fluid, a pre-infusion line (70) has a first end (70-1) connected to the replacement fluid container (78) and a second end (70-2) connected to the blood removal line (20) and a blood pump (22) is active on the blood circuit. A replacement fluid pump (72) is active on the pre-infusion line (70), a dialysate circuit (40, 50, 70) comprises an effluent line (50) configured for discharging fluid from the second chamber, and a control unit (80) is connected to the replacement fluid pump (72) and to the blood pump (22) and is configured for performing a rinse-back procedure for restituting blood to a patient. The rinse-back procedure comprises conveying blood contained in the blood circuit (10, 20, 30, 60) towards the second end (30-2) of the blood return line ...

Treatment fluid multi-stream blood warmer

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. A blood treatment system treats blood with multiple fluids and performs fluid balancing on a patient's blood compartment. Multiple streams influence the patient temperature but only a subset of the fluids are dynamically temperature regulated. The system regulates a temperature of the flow, for example, of dialysate in order to regulate the return temperature of blood, in such a way that the temperature effect of the multiple streams is compensated.

Heart-lung machine with augmented reality display

This document describes devices used during surgical procedures for the treatment of heart conditions. For example, this document describes technology to monitor the operations of a heart-lung machine and then shows associated read outs on a head-worn display in order to provide an augmented-reality presentation. For example, various sensors on and around a heart-lung machine, patient, and/or extracorporeal circuit can monitor the operations of the procedure using the heart-lung machine.

EXTRACORPOREAL OXYGENATION AND CO2 REMOVAL SYSTEM

Modular assembly for a portable hemodialysis system

A modular assembly for a portable hemodialysis system may include a dialysis unit, e.g., that contains suitable components for performing hemodialysis, such as a dialyzer, one or more pumps to circulate blood through the dialyzer, a source of dialysate, and one or more pumps to circulate the dialysate through the dialyzer, and a power unit having a housing that contains suitable components for providing operating power to the pumps of the dialysis unit. The power unit may be selectively connected to the dialysis unit and provide power (e.g., pneumatic power in the form of pressure and/or to vacuum) to the dialysis unit for the pumps when connected to the dialysis unit, but may be incapable of providing power to the dialysis unit when disconnected from the dialysis unit. The dialysis unit and the power unit are sized and weighted to each be carried by hand by a human.

Extracorporeal blood treatment apparatus

An extracorporeal blood treatment apparatus comprises: a blood treatment device; an extracorporeal blood circuit comprising a blood withdrawal line and a blood return line coupled to the extracorporeal blood treatment device, wherein the blood return line presents a heating zone coupled or configured to be coupled to a blood warmer; a blood pump configured to be coupled to a pump section of the blood withdrawal line; at least a post-infusion line connected to the blood return line upstream of the heating zone; an air trapping device placed on the blood return line upstream of the heating zone.

Combined Bio-Artificial Liver Support System

A combined bio-artificial liver support system, includes branch tubes that are connected in sequence: a blood input branch tube, an upstream tail end of which is set as a blood input end, a first plasma separation branch tube comprising at least a first plasma separator, a non-biological purification branch tube comprising at least a plasma perfusion device and a bilirubin adsorber, a biological purification branch tube comprising at least a hepatocyte culture cartridge assembly, and a plasma return branch tube, a downstream tail end of which is set as a blood output end.

ARTIFICIAL LUNG DEVICE

An artificial lung device comprising: a housing (2) formed in a tubular shape including both end portions that are closed, the housing including a blood inflow port (16) and a blood outflow port (17) and arranged such that a center axis of the housing is directed in a lateral direction; a gas exchanger (43) arranged in the housing and configured to perform gas exchange with respect to blood while the blood flows from the blood inflow port to the blood outflow port; a filter structure (56, 66) provided around the gas exchanger; and a bubble storing portion (70) provided between the filter structure and the gas exchanger, wherein the bubble storing portion is located at an upper side of the housing and faces the gas exchanger.

Blood sensor assembly

Devices used to sense physiologic blood parameters are disclosed. The devices may be configured to sense at least two physiologic blood parameters at substantially a common site of an extracorporeal perfusion circuit. The devices may include a pressure sensor and a temperature sensor. The temperature sensor may be in direct contact with the blood.

Blood circulation system

An artificial heart and lung apparatus (100) includes a roller pump (120); a blood removal line (101); a first blood transfer line (104); a blood removal rate sensor (111); a control unit (140) that performs the linked control of the roller pump (120) in correspondence with a blood removal rate; and a blood transfer rate adjustment unit (160) that instructs the roller pump (120) to transfer a blood transfer rate. The blood transfer rate adjustment unit (160) includes an operation amount input unit to which an operation amount from an arbitrary circumferential position can be input, and which outputs a pulse signal according to the input operation amount, and a counter that adds and subtracts pulse signals output from the operation amount input unit, and outputs a resultant as blood transfer rate adjustment data, and the counter performs a counting operation with respect to the circumferential position of the operation amount input unit when blood transfer control transitions to the normal ...

Devices and disposables for patient-specific cell therapy manufacturing

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Systems, assemblies, and methods of trauma management

A system for performing extracorporeal blood treatment of recovered blood can include a reservoir to receive a first portion of the recovered blood from a subject, an inline pump coupled the reservoir to regulate a flow rate of at least the first portion of the recovered blood, and an extracorporeal blood conditioner including at least one of an oxygenator to reoxygenate hemoglobin included in the recovered blood for at least intravenous delivery back to the subject or a temperature regulator configured to selectively control a temperature of the recovered blood.

BLOOD OXYGENATOR WITH AN ORGANIC MEMBRANE

The device for blood oxygenation includes a gas exchange chamber with passage openings. One side the chamber is connected in a gas-tight manner with the expansion tank feeding the gas mixture containing oxygen to the chamber, having the inlet opening of gas mixture from the feeding installation. The other side of the chamber is connected in a gas-tight manner with the gas mixture discharging tank, having the outlet opening of gas mixture. The inner part of the chamber has a membrane as a capillary bundle permeable to gas mixture particles and non-permeable to blood particles, ends of which are anchored in the passage openings. The capillary bundle is tensed with a tension force and is parallel to the longitudinal axis of the chamber and to each other, or are arranged spirally. The side wall of the chamber has at least one inlet/outlet opening.

HEMODIALYSIS SYSTEMS AND METHODS

The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. In some cases, a gas supply ...

Systems and methods for catheter feedback and control for AV fistula creation

A power controller device and system allows verification, monitoring, and control of an arteriovenous (AV) fistula creation catheter which comprises a main housing having a power supply, an embedded electronic controller and a user interface display, and which is configured to allow connection to an intravascular catheter. When activated, the device verifies that a valid catheter is connected, downloads stored manufacturing calibration data from the catheter, and provides a user interface to allow initiation of AV fistula creation. Once creation of the AV fistula is initiated, the device provides closed loop control of the catheter heating element and provides a means of monitoring the catheter temperature and tip position to a prescribed parameter to automate the arteriovenous fistula creation procedure.

Biological fluid treatment systems

Disclosed herein is systems, methods, and apparatuses for treating biological fluids. In some embodiments, the biological fluid treatment system includes a treatment, a platform, an array of light sources, and a display. In some embodiments, the biological fluid treatment system includes a scanner.

Oxygenation system

An oxygenator (10) for an extracorporeal ventilation system comprises a gas passage and a blood passage arranged to allow gas exchange of an oxygenation gas supply with blood via a gas-blood interface (34). The gas passage leads from a gas inlet zone (28) via the gas-blood interface (34) to a gas exhaust zone (40). The blood passage leads from a blood inlet (12) via the gas-blood interface (34) to a blood outlet (14). The oxygenator comprises a supply gas distribution arrangement (26, 28A, 28B). This allows the oxygenation gas supply to be modulated differently for different interface regions of the gas-blood interface. The oxygenator can be used to remove or reduce the formation of gaseous microemboli bubbles.

Combined bio-artificial liver support system

A combined bio-artificial liver support system, includes branch tubes that are connected in sequence: a blood input branch tube, an upstream tail end, a first plasma separation branch tube comprising at least a first plasma separator, a non-biological purification branch tube comprising at least a plasma perfusion device and a bilirubin adsorber, a biological purification branch tube comprising at least a hepatocyte culture cartridge assembly, and a plasma return branch tube, a downstream tail end of which is set as a blood output end.

Blood purification device

A blood purification device includes a blood circuit for extracorporeally circulating blood of a patient; a liquid supply circuit for supplying a supply liquid to the blood circuit or to a blood purifier provided on the blood circuit and a waste liquid circuit for discharging the waste liquid from the blood purifier. Each of the blood circuit, the liquid supply circuit and the waste liquid circuit comprises a flexible tube. The blood purification device comprises a tube identification unit that performs a tube identification process for identifying a tube used for the blood circuit, the liquid supply circuit or the waste liquid circuit or determining whether or not there is an abnormality in the tube, based on an amount of liquid sent from a peristaltic pump provided on the blood circuit, the liquid supply circuit or the waste liquid circuit, or pressure fluctuation in the circuit, caused when driving the pump for a predetermined time.

MODULAR HEATER COOLER WITH DISPOSABLE HEAT TRANSFER FLUID CIRCUIT

A system (20) including a heater/cooler module (22) to heat/cool a first fluid in a primary circuit (28), a heat transfer fluid circuit (24) to provide a second fluid to a target device (38) to heat/cool the target device (38), and a heat exchanger (26) including at least part of the primary circuit (28) and at least part of a secondary circuit (36) through which the second fluid flows to facilitate heat transfer between the first fluid and the second fluid. The primary circuit (28) and the secondary circuit (36) are separate circuits and the first fluid and the second fluid remain separated in the system. Also, the system is modular, such that the elements can be stacked to increase heating/cooling capability and/or to increase the number of heating/cooling channels, and the system is compatible with portable applications, such as ambulance, aircraft, and helicopter applications, and with battery opera-tion and/or the use of uninterruptible power supplies.

Medical device for introduction of a fluid into the blood circulation system of a patient and method for controlling leakage currents in a medical device provided or combined with a warming unit

A warming unit (21) coupled or configured to be coupled to a heated portion (19) of a fluid circuit (6, 7, 10, 11, 13, 14, 15; 107) of a medical device (1, 100). The warming unit (21) comprises a leakage current reduction circuit (35) configured to perform the following procedure: connecting a heat transfer element (22) of the warming unit (21) to a ground connection (33) through a resistance element (34), which keeps a normal condition patient leakage current below a first limit value, and disconnecting the heat transfer element (22) from the ground connection (33) if a current indicating that a patient is connected to a mains voltage is sensed through the resistance element (34), in order to keep a fault condition patient leakage current below a second limit value.

HEAT TRANSFER LIQUID FOR A TEMPERATURE CONTROL DEVICE FOR EXTRACORPOREAL CIRCULATION

The present application refers to a heat transfer liquid for a temperature control device for human body temperature control during extracorporeal circulation, a temperature control device, the use of heat transfer liquid for extracorporeal circulation and a method of human body temperature control using a heat transfer liquid. The head transfer liquid consists of ethylene glycol or propylene glycol at about 25 volume-percent to about 35 volume-percent, hydrogen peroxide at 0.05 volume-percent or less and sterile, filtered and de-mineralized water as rest.

MEMBRANE OXYGENATORS

Embodiments of the present disclosure provide a membrane oxygenator including an upper cover, a lower cover, a shell, and an oxygenation structure. Both ends of the shell are connected with the upper cover and the lower cover respectively. The oxygenation structure includes a mandrel, an oxygen pressure membrane, and a temperature-changing membrane, wherein an upper end of the mandrel enters a first blood path space of the upper cover, a lower end of the mandrel is opposite to a blood outlet of the lower cover, the oxygen pressure membrane is provided around the mandrel and connects a first gas path space and a second gas path space, and the temperature-changing membrane wraps around the oxygen pressure membrane. A gap is provided between the temperature-changing membrane and an inner wall of the shell. A blood inlet is provided on the shell near the upper cover.

SYSTEMS AND METHODS FOR CONTROLLING BLOOD TEMPERATURE IN EXTRACORPOREAL BLOOD CIRCUITS

An extracorporeal blood circuit is provided. The extracorporeal blood circuit includes a blood pump including an inlet, an outlet, and a rotor positioned between the inlet and the outlet, and a controller coupled to the blood pump. The controller is configured to drive rotation of the rotor using a voltage waveform and a current waveform, and adjust a phase angle between the voltage waveform and the current waveform to generate reactive power. The generated reactive power facilitates heating blood as the blood passes through the blood pump.

Devices, systems and methods for reducing the concentration of a chemical entity in fluids

A method of improving the blood compatibility of a blood-contacting surface includes immobilizing carbonic anhydrase on the surface, wherein the surface exhibits carbonic anhydrase activity of at least 20% of maximum theoretical activity of the surface based on monolayer surface coverage of carbonic anhydrase.

System and method for blood separation by microfluidic acoustic focusing

Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating undesirable particles bound to capture particles from formed elements of whole blood. After introducing the capture particles to whole blood containing undesirable particles, the whole blood and capture particles are flowed through a microfluidic separation channel. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements and undesirable particles bound to capture particles to specific aggregation axes. After aggregating the particles, the formed elements exit the separation channel through a first outlet and are returned to the patient. The undesirable particles, bound to the capture particles, exit through a second outlet and can be discarded to saved for later study.

Cardiopulmonary bypass or cpb monitoring tool

A cardiopulmonary bypass or CPB monitoring tool includes: a preoperative information module; a preoperative calculation module able to estimate a body surface area, blood volume, and theoretical weight; a priming module able to determine priming constitution, volume and flow to achieve a hemodilution target; an operation risk module for calculating operation risk; a drug calculation module able to determine medication doses; a timer module with timers that can be activated during operation; a data collection module with an interface and drivers enabling data collection from a wide variety of extracorporeal pumps and oxygenators during operation; an events module with retroactive manipulation of the time of an event; a printing report generation module; a graphic user interface; and a configuration module.

Device for treating blood in an extracorporeal circulation

A device for oxygenating blood during extracorporeal circulation includes a box-like body having a first end and a second end opposite thereto and defining therebetween a treatment chamber with an inner surface. The device further includes, in the treatment chamber, at least one exchange unit having at least one flat diaphragm that is impervious to blood and has a major axis and a minor axis. The diaphragm has a winding of hollow microporous fibers. The device further includes an inlet port and an outlet port axially aligned with one another in an alignment direction. A compartment is provided for accumulation and delivery of blood to be treated, another compartment for collecting treated blood, the compartments being located downstream of the inlet port and upstream of the outlet port, between the exchange unit and the inner surface of the treatment chamber. The diaphragm is disposed with the major axis parallel to the alignment direction.

Portable medical apparatus for cardiopulmonary aid to patients

A portable medical apparatus ( 1 ) for cardiopulmonary aid to patients (P) comprises: an extracorporeal circuit ( 500 ) for circulating the blood of a patient (P), which in turn comprises a line ( 200 ) for drawing venous blood from a patient (P) and a line ( 300 ) for returning arterial blood to said patient (P); at least one filtering arrangement ( 5, 6 ) placed on said extracorporeal circuit ( 500 ); a pumping unit ( 10 ) for pumping blood along the extracorporeal circuit ( 500 ); a heat exchanger ( 100 ) having an exchange body ( 101 ) for thermoregulating blood in said extracorporeal circuit ( 500 ); an oxygenator unit ( 111 ) for blood oxygenation; said medical apparatus comprising a transportable machine body ( 2 ) in which at least one seat ( 21 ) is formed for removable coupling with said exchange body ( 101 ).

Blood perfusion system

An extracorporeal blood perfusion system includes a disposable assembly and a control unit having a control interface region. The interface region includes pump assemblies for selective pumping of venous blood, arterial blood, cardioplegia solution, suctioned blood and blood removed from the left ventricle. Valve assemblies control the flow of fluids through the assembly and to/from the patient and sensors monitor various fluid parameters including temperature and pressure within the various fluid circuits. The user interface is a functional screen interface for effecting the operation of the control unit and valve assemblies. The screen interface may be a touch screen having objects that corresponds to the component interface region. The display may be selectively controlled to provide graphic depictions of disposable assembly components with corresponding narrative instructions.

Treatment Fluid Multi-Stream Blood Warmer

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. A blood treatment system treats blood with multiple fluids and performs fluid balancing on a patient's blood compartment. Multiple streams influence the patient temperature but only a subset of the fluids are dynamically temperature regulated. The system regulates a temperature of the flow, for example, of dialysate in order to regulate the return temperature of blood, in such a way that the temperature effect of the multiple streams is compensated.

Cell washing apparatus

A cell washing apparatus is provided to wash a cell-containing fluid. The apparatus is arranged to exchange one or more exchangeable entities from a cell-containing first fluid, and comprises, a first fluid conduit and a second fluid conduit, the second fluid conduit separated from the first fluid conduit by a semi-permeable membrane disposed therebetween; the first fluid conduit having a first fluid inlet and a first fluid outlet, the first fluid conduit arranged to transport the first fluid in a first direction between the first fluid inlet and the first fluid outlet; the second fluid conduit being arranged to house a second fluid; wherein the semi-permeable membrane comprises a plurality of pores arranged to permit transport of said one or more exchangeable entities from the first fluid to the second fluid; wherein the one or more exchangeable entities comprise free haemoglobin and/or blood plasma; and wherein the first fluid is whole blood isolated from a human body, or packed red blood cells. The cell washing apparatus of the present invention aims to solve the problem of harmful species that accumulate in a cell-containing fluid (such as, for example, transfusion blood) during storage and other applications, in which it is desired to transfer red blood cells to a clean suspending liquid.

Systems, methods, and devices for artificial placentas and amniotic bed incubators

Described herein are systems, devices, and methods for an extracorporeal, artificial, placenta. In some embodiments, an artificial placenta and amniotic bed system may comprise a control unit, a gas delivery unit, a gas exchange unit or membrane oxygenator, a fluids delivery unit, an amniotic fluid bed, and a human machine interface. In some embodiments, the artificial placenta and amniotic bed systems, devices, and methods described herein may improve survival rates and minimize long-term disabilities in preterm, gestational-age, newborns. In some embodiments, the extracorporeal systems, devices, and methods comprise an artificial network through which oxygen and nutrient-rich blood may flow into a fetus (residing in an amniotic fluid bed), while carbon dioxide and wastes may be removed, thus re-establishing a form of intrauterine placental circulation.

Artificial lung and method for manufacturing artificial lung

An artificial lung is provided having a plurality of porous hollow fiber membranes for gas exchange, in which the hollow fiber membranes have outer surfaces, inner surfaces forming lumens, and opening portions through which the outer surfaces communicate with the inner surfaces, any one of the outer surfaces and the inner surfaces is coated with a colloidal solution of an antithrombotic material containing a polymer as a main component, and an average particle size of the colloid is at least 1.5 times a diameter of the opening portions of the hollow fiber membranes. An artificial lung is provided that can effectively suppress leakage of blood plasma components after blood circulation (blood plasma leakage).

Hemodialysis System

A dialysis system comprises a filtration means, a pump and a sorbent device for performing a dialysis treatment and/or for regenerating a dialysate solution.

Injection cannula, ecmo system

The invention relates to a cannula ( 1 ) for injecting a fluid (F 1 ) into a body cavity ( 5 ), comprising: a main lumen (LP) for the fluid to flow in a first direction; an accessory reperfusion lumen (LA) comprising an outlet ( 20′ ) for discharging the fluid in a second direction; and a device for positioning the cannula in the cavity, the device comprising a stop ( 41 ) which can move along an auxiliary lumen (LX) and be deployed in the cavity in order to lock the cannula in position in the cavity, the outlet ( 30′ ) of the auxiliary lumen being arranged at a distance (d) from the outlet ( 20′ ) of the accessory reperfusion lumen such that when the cannula is locked in position in the cavity, the outlet ( 20′ ) of the accessory reperfusion lumen (LA) is oriented in the cavity such that the collected fluid is discharged in the second direction.

Modular assembly for a portable hemodialysis system

A modular assembly for a portable hemodialysis system may include a dialysis unit, e.g., that contains suitable components for performing hemodialysis, such as a dialyzer, one or more pumps to circulate blood through the dialyzer, a source of dialysate, and one or more pumps to circulate the dialysate through the dialyzer, and a power unit having a housing that contains suitable components for providing operating power to the pumps of the dialysis unit. The power unit may be selectively connected to the dialysis unit and provide power (e.g., pneumatic power in the form of pressure and/or vacuum) to the dialysis unit for the pumps when connected to the dialysis unit, but may be incapable of providing power to the dialysis unit when disconnected from the dialysis unit. The dialysis unit and the power unit are sized and weighted to each be carried by hand by a human.

Modular extracorporeal ambulatory lung assist device

A system for lung assist includes a plurality of fiber bundle sections. Each of the fiber bundle sections includes a fiber bundle housing defining a fiber bundle compartment therein and a fiber bundle positioned within the fiber bundle compartment. The fiber bundle includes a plurality of hollow gas permeable fibers configured to permit diffusion of gas between blood and an interior of the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers is positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment. Each fiber bundle is different in at least one property from each other fiber bundle. The fiber bundle housing further includes a gas inlet in fluid connection with the fiber bundle housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers, a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers, and a blood outlet in fluid connection with a first end of the fiber bundle. The fiber bundle housing also includes a first interface. The system further includes a base section including a housing including a pressurizing compartment, a pressurizing mechanism within the pressurizing compartment, a blood inlet in fluid connection with the pressurizing compartment and a conduit in fluid connection with the pressurizing compartment at a first end thereof via which pressurized fluid exits the pressurizing compartment. The base further includes a second interface adapted to form a releasable, sealing connection with the first interface of one of the plurality of fiber bundle sections. A second end of the conduit is placed in fluid connection with a second end of the fiber bundle when the fiber bundle section is connected to the base section via the first interface and the second interface.

Oxygenator with thermal insulation

An oxygenator includes a housing having a blood inlet and a blood outlet, the blood inlet extending into an interior of the housing. A heat exchanger is disposed within the housing, and is coupled, at an inlet end, to a heat-exchange fluid inlet. A gas exchanger also is disposed within the housing, and includes a bundle of gas-exchange fibers coupled, at a gas outlet end, to a gas-exchange fluid outlet. The oxygenator includes at least one insulator configured to thermally insulate at least the gas outlet end of the bundle of gas-exchange fibers.

Modular extracorporeal ambulatory lung assist device

A system for lung assist includes a plurality of fiber bundle sections which includes a fiber bundle housing defining a fiber bundle compartment with a fiber bundle positioned within. The fiber bundle includes a plurality of hollow gas permeable fibers. The fiber bundle housing further includes a gas inlet in fluid connection with the fiber bundle housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers, a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers, and a blood outlet in fluid connection with a first end of the fiber bundle. The system further includes a base section including a housing including a pressurizing compartment, a pressurizing mechanism within the pressurizing compartment, a blood inlet in fluid connection with the pressurizing compartment and a conduit.

Anesthesia system for cardiopulmonary bypass machine

Methods and systems are provided for anesthesia systems for heart-lung machines. In one embodiment, a system comprises: a cardiopulmonary bypass machine; and an anesthesia machine operably coupled to the cardiopulmonary bypass machine, the anesthesia machine adapted to control a flow of vapor through the cardiopulmonary bypass machine.

Extracorporeal blood treatment apparatus and method for checking the connection of a soft bag in an extracorporeal blood treatment apparatus

An extracorporeal blood treatment apparatus (1) and a method for checking the connection of a soft bag (30, 24; 33, 34) in the apparatus (1). The apparatus (1) comprises a blood treatment device (2), an extracorporeal blood circuit (3, 5) and a fluid circuit (8, 12, 15, 17, 18, 22; 41, 42, 44). A control unit (32) is configured to check the connection of a soft bag (30, 24; 33, 34) to the extracorporeal blood circuit (3, 5) or to the fluid circuit (22; 41, 42, 44) through the following procedure: sucking a medium from a connecting zone (29) through a blood pump (6) or a fluid pump (23; 37, 39) of the apparatus (1); measuring at least a pressure trend (P1, P1-P2, P2-P1, Pwdr, Pwdr-Pret, Pret-Pwdr) over time in the extracorporeal blood circuit (3, 5) or in the fluid circuit (22; 41, 42, 44) through at least a pressure sensor (25, 26); establishing from said measured pressure trend (P1, P1-P2, P2-P1, Pwdr, Pwdr-Pret, Pret-Pwdr) if the soft bag (30, 24; 33, 34) is connected to the extracorporeal blood circuit (3, 5) or to the fluid circuit (22; 41, 42, 44) at the connecting zone (29).

Fluid Pump Systems, and Related Methods for Pumping Biological Fluids

The present invention relates to a fluid pump system ( 64 ) having a fluid reservoir ( 21 ) comprising a first cavity ( 29 ) and a second cavity ( 30 ) in fluidic communication with each other and adapted to accommodate a biological fluid ( 7 ). The fluid reservoir ( 21 ) is connected to a fluid-container system ( 27 ) and a target ( 5 ) is in fluidic communication with the second cavity ( 30 ). A pressurization system is adapted to generate a first pressure below ambient pressure in the first cavity ( 29 ) and generate a second pressure in the first cavity ( 29 ). The second pressure is also applied to the second cavity ( 30 ). The fluid pump system ( 64 ) thereby causes flow of the biological fluid ( 7 ) from the fluid-container system ( 27 ) into the first cavity ( 29 ), from the first cavity ( 29 ) into the second cavity ( 30 ), and from the second cavity ( 30 ) to the target ( 5 ).

Cartridge and method for increasing myocardial function

The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions that affect myocardial function and to related methods. The cartridge can be used in treating a subject with myocardial dysfunction, such as a subject with chronic heart failure and/or acute decompensated heart failure.

Systems and methods for oxygenator performance evaluation

Systems and methods for monitoring oxygenator performance in extracorporeal circuit systems or the like. More particularly, the disclosure relates to systems and methods including a controller programmed to determine oxygenator apparatus flow impedance as a function of an inlet pressure measurement, an outlet pressure measurement and a blood flow rate measurement. The systems and methods may include a communication device that receives signals from the controller to communicate information regarding oxygenator apparatus performance.

Apparatus relating to hemodialysis, hemodiafiltration, hemofiltration or peritoneal dialysis having function for rise temperature

Disclosed is an apparatus having a heating function for hemodialysis, hemodiafiltration, hemofiltration or peritoneal dialysis, wherein the apparatus includes at least one of pipe for transferring at least one fluid of blood and dialsate, and a heating unit for heating at least one fluid of blood and dialsate, wherein the fluids to be heated by the heating unit are substances to be injected into human body; and the heating unit is arranged for measuring flow rates of the fluids to be heated, and injecting temperatures related with the flow rate to heat the fluids to be heated. The heating unit comprises: flow passages through which the fluids to be heated are flowed; a heater formed as a part of the flow passages, for generating heat; and a cover means including a first connection portion through which the fluids enter the flow passages, and a second connection portion through which the fluids come out from the flow passages. Present invention provides one effect in that blood having the same or nearly same temperature as that of human body can be injected into human body to prevent side effects caused by the dialysis and another effect in that blood can be heated effectively because the shapes of flow passages around the heater is deformed in improved manner.

Systems and methods for pressure-regulated volume control during cardiopulmonary bypass and perfusion procedures

Systems and methods for regulating fluid volume from an isolated cardiac circuit during cardiopulmonary bypass surgery are described. In one embodiment, a system in accordance with the present technology can include a pressure-regulated volume control unit configured to regulate a cardiac circuit volume based on a measured return pressure detected at an outflow from an internal heart portion of cardiac circuit. The system can also include a first pressure sensor configured to detect the measured return pressure.

Limb stabilisation apparatus and methods

A limb-stabilisation apparatus (100) comprises a limb-receiving container (110) arranged to receive a portion of the limb (5) and to collect blood exited from the limb; and a blood recirculation system (120) configured to recirculate blood from the limb-receiving container (110) to one or more regions of the limb. Advantageously, the limb-stabilisation apparatus (100) may further comprise or may be associated with a limb-compressing apparatus (210) configured to reduce, restrict or prevent blood flow in the region of the limb-compressing apparatus.

Separation membrane module

A separation membrane module includes a separation membrane including a hydrophobic polymer, a hydrophilic polymer, and polymer A, wherein the polymer A includes a hydrophilic unit and a hydrophobic unit, and is a copolymer having an alkyl group having 2 to 20 carbon atoms at a side-chain terminal of the hydrophobic unit, the separation membrane module having a retention rate of an albumin sieving coefficient of 86% or more at 60 minutes after circulation start relative to an albumin sieving coefficient at 10 minutes after circulation start when 2 L of bovine blood containing 50 U/ml of heparin, and having a hematocrit of 30% by volume and a total protein concentration of 6 to 7 g/dl is circulated at a flow rate of 100 ml/min at 37° C. and a filtration flow rate of 10 ml/(min·m 2 ).

Methods and systems for removing carbon dioxide

Systems and methods suitable for extracorporeal lung support are provided that expose blood, across a semipermeable membrane, to a dialysis liquid. The dialysis liquid features a buffering agent and has a high buffering capacity for H+ ions. Carbon dioxide, bicarbonate and hydrogen cations are transported across a semipermeable membrane into the dialysis liquid. The dialysis fluid may be recycled and repeatedly used, and its pH may be adjusted, and other fluids added to it. Certain substances may be removed from the blood, and the amount of these substances removed from the blood may be substantially automatically or substantially continuously monitored or quantified. The systems and methods are suitable for treating or preventing respiratory acidosis, metabolic acidosis, and diseases featuring lung malfunction, kidney malfunction, or liver malfunction.

Systems and methods for limb treatment

A method of delivering a medicament to a limb of a patient body includes isolating a circulatory system of the limb from a circulatory system of the patient body, wherein the limb circulatory system is substantially all limb arteries and substantially all limb veins located between an isolation region and an end of the limb. A perfusion catheter is inserted into a limb artery in an antegrade position, while a collection catheter is inserted into a limb vein in a retrograde position. The blood flow of the limb circulatory system is then circulated by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter. A medicament is perfused into the limb circulatory system with the perfusion catheter.

Prediction display system and treatment method

To provide a prediction display system and the like that utilize information obtained before an operation and during the operation, and predict an onset risk of a postoperative complication such as an acute kidney injury which has become a particularly great clinical problem. A prediction display system is configured such that an onset risk of a complication occurring after an operation is predicted using at least one of pH (hydrogen ion exponent), pO2 (oxygen partial pressure), Ht (hematocrit value), Hb (hemoglobin), DO2 (transportation amount of oxygen), and pCO2 (arterial blood carbon dioxide partial pressure) as parameters of blood gas taken before the operation and during the operation, and the onset risk of the complication occurring after the operation is displayed.

Material for blood purification

An object of the present invention is to provide a material for blood purification having the capability to remove cytokines and activated leukocyte-activated platelet complexes. The present invention provides a material for blood purification, the material containing a water-insoluble material in which a ligand having an amide group(s) and an amino group(s) is bound to a substrate, wherein the content of the amide group(s) is 3.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material; and wherein the content of the amino group(s) is 1.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material.

Bioartificial liver system

A bioartificial liver system is described that incorporates a cell reservoir and hepatocyte spheroids to both increase the number of and longevity of cells in the system. Additional methods are also described for forming spheroid aggregates from isolated hepatocytes.

Hollow- fiber membrane blood purification device

The present invention provides a hollow-fiber membrane blood purification device obtained by filling a container with a hollow-fiber membrane, in which the hollow-fiber membrane contains a hydrophobic polymer, a hydrophilic polymer and a lipid-soluble substance; the amount of the lipid-soluble substance on the inner surface of the hollow-fiber membrane is 10 mg/m 2 or more and 300 mg/m 2 or less; and the oxygen transmission rate of the container is 1.8×10 −10 cm 3 ·cm/(cm 2 ·s·cmHg) or less.

Physiologic cardiovascular ph balanced counter current electrolyte transfer and fluid removal system

Certain embodiments of the invention are directed to methods of adjusting the concentration of one or more electrolytes in a patients blood using a counter current electrolyte solution.

Apparatus and method for providing enhanced heat transfer from a body

Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within a control unit. The control unit includes a heater/cooler device for providing heated or cooled fluid to a heat exchanger in thermal communication with the fluid heat exchange medium circulating to the heat exchange catheter, a user input device, and a processor connected to receive input from various sensors around the body and the system. A temperature control scheme for ramping the body temperature up or down without overshoot is provided.

Blood circulation system

The preset invention discloses an artificial heart and lung apparatus ( 100 ) including a roller pump ( 120 ); a blood removal line ( 101 ); a first blood transfer line ( 104 ); a blood removal rate sensor ( 111 ) and a control unit ( 140 ) that performs linked control of the roller pump ( 120 ) in correspondence with a blood removal rate. The control unit ( 140 ) is capable of detecting that the blood removal rate deviates from a blood removal condition set in advance, and out-of-set condition blood removal is performed.

Cartridge and method for increasing myocardial function

The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions that affect myocardial function and to related methods. The cartridge can be used in treating a subject with myocardial dysfunction, such as a subject with chronic heart failure and/or acute decompensated heart failure.

Method and apparatus for assessing cardiac output in veno-arterial extracorporeal blood oxygenation

A system for calculating cardiac output (CO) of a patient undergoing veno-arterial extracorporeal oxygenation includes measuring first oxygenated blood flow rate by a pump in the extracorporeal blood oxygenation circuit as introduced into an arterial portion of the patient circulation system and a corresponding arterial oxygen saturation, then changing the pump flow rate, such as decreasing, to produce a corresponding change in arterial oxygen saturation (wherein such change is outside of normal operating variances, operating errors or drift), which change in the arterial oxygen saturation is measured. From the first flow rate and the second flow rate along with the corresponding measured arterial oxygen saturation, the CO of the patient can be calculated, without reliance upon a measure of venous oxygen saturation. Alternatively, the CO of the patient can be calculated, without reliance upon a change in flow rate by changing a gas exchange with the blood in the extracorporeal blood oxygenation circuit to impart corresponding changes in a blood parameter in the arterial portion of the patient circulation system and the blood delivered from the extracorporeal blood oxygenation circuit.

Liver support system

An artificial, extracorporeal system for liver replacement and/or assistance, comprises a liver dialysis device for conducting hemodialysis on a patient suffering from liver failure. The liver dialysis device comprises a first standard hollow fiber membrane dialyzer which does not allow passage of an essential amount of albumin over the membrane wall and which is perfused with the patient's blood, and a second hollow fiber membrane dialyzer which allows the passage of essential but defined amounts of albumin over the membrane wall and which receives the blood of the first standard hemodialyzer. The filtrate space is closed off from the lumen space of the hollow fibers and is populated by adsorbent material which may comprise one or more different adsorbents.

Device with a fluid pump, at least two points of access to the abdominal wall and tubes connecting the fluid pump and abdominal wall

A device with a blood pump, at least two points of access to the abdominal wall and tubes connecting the blood pump and points of access to the abdominal wall, which is known as a peritoneal dialysis system, is equipped with a CO 2 removal arrangement, in order to use it tor blood oxygenation and/or CO 2 removal.

Blood gas exchanger with restriction element or elements to reduce gas exchange

Described is a gas exchanger with a restriction element or elements to reduce gas exchange as desired to avoid hypo-capnia and hyper-oxygenation in small patients. The gas exchanger includes a gas exchanger housing with an outer wall and a core which defines an inner wall and having a blood inlet for receiving a blood supply and a blood outlet. The gas exchanger also includes: a hollow fiber bundle disposed within the housing between the core and the outer wall; and a gas inlet compartment for receiving an oxygen supply and directing the oxygen supply to first ends of the hollow fiber bundle, wherein the gas inlet compartment includes at least one restriction element configured to allow the oxygen supply to reach only a portion of the hollow fiber bundle.

Blood circulation system

Disclosed is an artificial heart and lung apparatus ( 100 ) that can be connected to a patient (P), and transfers removed blood to a human body via a roller pump ( 120 ), the system including: the roller pump ( 120 ); a blood removal line ( 101 ) which transfers removed blood to the roller pump ( 120 ); a first blood transfer line ( 104 ) that transfers blood, which is transferred from the roller pump ( 120 ), to the human body; a blood removal rate sensor ( 111 ) that is provided in the blood removal line ( 101 ); and a control unit ( 140 ), in which the control unit ( 140 ) performs control such that a blood transfer rate of the roller pump ( 120 ) is in a specific range with respect to a blood removal rate measured by a blood removal rate sensor ( 111 ).

Blood circuit assembly for a hemodialysis system

A blood circuit assembly for a dialysis unit may include an organizing tray, a pair of pneumatic pumps mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient, an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit, a pair of dialyzer connections arranged to connect to the inlet and outlet of a dialyzer unit, and a pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient.

Medical reservoir level sensor

Devices can be used for detecting a level of a fluid in a medical fluid reservoir and for controlling the level. For example, this documents describes devices and methods for controlling the flow rate of a medical pump, and/or the occlusion amount of a medical fluid tube, based on the detected level of fluid in the medical reservoir.

Heat exchanger and oxygenator

A heat exchanger for a blood circulation circuit includes a hollow fiber membrane layer having a plurality of laminated hollow fiber membranes 31. Each of the hollow fiber membranes 31 has a barrier layer 5 having a hydrogen peroxide barrier property, and the barrier layer 5 has an oxygen permeability coefficient of 6 cc·cm/m2·24 h/atm or less at 25° C.

Oxygenator and method for manufacturing the same

In manufacturing an oxygenator (10), an intermediate spacer (18) is arranged between an inner cylinder unit (13) configured by winding a first hollow fiber membrane (14a) and an outer cylinder unit (15) configured by winding a second hollow fiber membrane (16a) so that a first gap (100a) is formed between one end portions of the inner cylinder unit (13) and the outer cylinder unit (15), and a first partition section (62a) is inserted into the first gap (100a). A first end portion (18a) of the intermediate spacer (18) is located at a region which does not overlap the first partition section (62a) in a radial direction. The intermediate spacer (18) independently supports the outer cylinder unit (15) in a state in which a gap (Sa) is formed between an inner peripheral surface of the intermediate spacer (18) and an outer peripheral surface of the inner cylinder unit (13).

Extracorporeal fluid heat exchange

A heater cooler apparatus 1 for a perfusion system heat exchanger 26, where the heater-cooler apparatus 1 comprises a heater cooler device 10 and an antimicrobial fluid. The anti-microbial fluid may be a heater-cooler fluid 11. Heater-cooler apparatus 1 may further comprise an intermediate heat exchanger 40 between the heater-cooler device 10 and an intermediate passage 30, where the heater-cooler device 10 supplies the heater-cooler fluid 11 to intermediate heat exchanger 40, where the intermediate passage 30 supplies an intermediate fluid 31 to the perfusion system heat exchanger 26 and where the intermediate heat exchanger 40 permits heat exchange between the heater-cooler fluid 11 and the intermediate fluid 31, where the heater-cooler fluid 11 is fluidly isolated from the perfusion system heat exchanger 26. The antimicrobial fluid may be intermediate fluid 31. Preferably the antimicrobial fluid is biocidal. The antimicrobial fluid may comprise glycol. Also use of an antimicrobial fluid in an extracorporeal perfusion system and a method of setting the temperature of an extracorporeal fluid passing through a perfusion system heat exchanger. The provision of antimicrobial fluid is described as reducing risk of microbe contamination of an extracorporeal fluid and reducing the requirement for time consuming manual sterilisation procedures.

[UNK]

Actuator apparatus for a prepackaged fluid processing module having pump and valve elements operable in response to externally applied pressures

A fluid processing apparatus for use in conjunction with a prepackaged disposable fluid processing module of the type which includes an integral housing wherein fluid containers, tubing segments, and other components required in processing a fluid are contained, and wherein fluid communication between the containers, components and tubing segments is provided by a fluid circuit formed within the housing by a first relatively inflexible fluid-impervious sheet member and a second relatively flexible fluid-impermeable sheet member. The fluid circuit includes pump and valve elements which operate in response to pressures applied to the second sheet member. Upon installation of the system in the processing apparatus pneumatic actuator ports apply pressures to the second sheet member through access apertures in the housing to circulate fluid through the fluid circuit.

System for extrakorporeal blodbehandling

Fluid monitor system

Systems for monitoring fluids such as blood being treated extracorporeally are disclosed, including a monitor for monitoring the fluid flow through a tube system between a fluid inlet, fluid treatment means and a fluid outlet. The monitor disclosed includes a monitor housing which contains at least one pressure sensor, and a cassette which is adapted to be removably coupled to the monitor housing, the cassette including pressure transmission ducts for transmitting the pressure within the tube system to a pressure transmitting cavity adapted to be juxtaposed with the pressure sensor when the cassette is coupled to the monitor housing so that the pressure within the tube system can be directly measured by the pressure sensor when the cassette is coupled to the monitor housing. In one embodiment of the monitor the cassette includes a portion of the tube system, while in another embodiment a conventional tube system can be affixed to the cassette.

Prepackaged fluid processing module having pump and valve elements operable in response to applied pressures

A disposable prepackaged fluid processing module includes an integral housing wherein fluid containers, tubing segments, and other components required in processing a fluid are contained. Fluid communication between the containers, components and tubing segments is provided by a fluid circuit formed by a panel of the housing, and an overlying fluid-impermeable flexible sheet member. The fluid circuit includes pump and valve elements which operate in response to pressures applied to the sheet member. Upon installation of the system in a related actuator apparatus pneumatic actuator ports apply pressures to the pump and valve elements to circulate fluid through the fluid circuit.

Computer-control medical care system

A computer-controlled medical care system for use in the treatment and diagnosis of patients provides for either automatic or manual control of a wide variety of medical procedures including diagnostic procedures. The system accepts modular vessel structures, each type of structure being adapted for carrying out a specific procedure and matching programs for carrying out the specific procedures. A microcomputer accepts a program which may be designed to fit the needs of a specific patient and which must match the modular vessel structure. The microcomputer monitors the progress of the process and the physiologic status of the patient and provides for the taking of appropriate steps should difficulties be encountered in carrying out the procedure. The system can also be programmed to analyze a fluid taken from an individual, to treat the fluid and return same to the individual and to schedule the infusion of appropriate medications. Embodiments of the system provide for carrying out only a limited group of procedures where a full-range system is undesirable either because unnecessary or uneconomic. Modular vessel structures are keyed to specific programs, thereby preventing operator errors and increasing the reliability of the system.

Variable capacity reservoir assembly

A variable capacity reservoir assembly for use in a blood oxygenation system which includes a collapsible reservoir and an elongated unitary clamp. The reservoir is of fluid-impermeable flexible material and includes an expandable portion capable of holding a predetermined maximum volume of blood. The reservoir also includes one main blood inlet and one main blood outlet. The clamp is bifurcated and slidably engages the reservoir, preferably between the inlet and the outlet and grasps the expandable portion so as to control the expansion thereof and thereby control its blood holding capacity.

Membrane plasmapheresis apparatus and process which utilize a flexible wall to variably restrict the flow of plasma filtrate and thereby stabilize transmembrane pressure

A membrane plasmapheresis system introduces a flow of whole blood subject to a predetermined inlet pressure into a fluid path across a membrane which is suited for filtering the plasma from the whole blood and across which a predetermined pressure drop occurs. The plasma-poor blood is conducted from the membrane subject to a determinable plasma-poor blood pressure. Likewise, plasma filtrate is conducted from the membrane subject to a determinable plasma-filtrate pressure. The conduction of plasma filtrate is metered in response to the existent plasma-poor blood pressure to achieve and thereafter maintain substantial equilibrium between the plasma-poor blood pressure and the plasma filtrate pressure. A substantially constant transmembrane pressure can thereby be maintained at a level below which hemolysis occurs.

Venous reservoir

A venous reservoir is provided in which a blood inlet (42) is located at an inlet end (70) of the container (48) which extends upwardly with a fast rise and for a sufficient distance to allow the blood entering the inlet to enter a large volume and to expand rapidly. The top (74) of the inlet end wall (70) of the container communicates with a vent outlet (46) whereby a sharp decrease in the velocity of the blood flow resulting from its rapid expansion provides buoyancy to air in the blood causing air bubbles to rise to the top of the container and be vented through the vent opening. A top wall (76) of the container extends from the vent opening and toward a blood outlet (44), with the top wall being curved in a manner to prevent the velocity of blood from increasing until the blood is substantially at the blood outlet. The top wall (76) includes a curved portion (80) opposite to the inlet end (70) whereby the air bubbles that have not been discharged immediately upon entering the reservoir may flow back up the top wall to the vent opening.

Integrated membrane oxygenator, heat exchanger and reservoir

A membrane oxygenator includes an upper nested arrangement of a hard shell venous reservoir, a bowl-like defoamer within the reservoir and a heat exchanger coil vertically supported within the defoamer, and includes a membrane oxygenator unit mounted on the bottom of the upper arrangement. The oxygenator unit includes an inlet chamber with a tangential inlet providing swirling blood flow to dislodge air bubbles and centrifuge air to an upper center region of an inlet chamber where gas is exhausted through a vent. A bottom blood outlet chamber of the blood oxygenator unit has a relatively thin vertical cross-sectional area such that priming flow velocity therein discharges all air from the outlet chamber.

Extracorporeal blood circuit

An extracorporeal blood circuit in which a blood oxygenator is placed in series between a first and second pump, the pumps being of the peristaltic or ventricular type, the inlet to the first pump being connected to patient''s vein and the outlet of a second pump to a patient''s artery. The useful internal volume of the body of the first and second pumps varies substantially proportional to the pressure of the blood at the inlet, between minimum and maximum values, the maximum useful volume of the first pump and the minimum useful volume of the second pump being reached at a pressure of the blood at the inlet of the respective pump within a range of atmospheric pressure + OR - 20 mm mercury.

Power infuser

A modular, power augmented medical infusion apparatus to provide rapid transfusion of relatively large quantities of blood, blood components, colloid, and fluids to patients. All components of the infuser that contact blood are sterlie, disposable, and easily assembled. Disassembled or partially assembled the components are also easily transportable. The major components comprise a pair of filtered cardiotomy reservoirs, an air embolus sensor, a modular double roller pump, a heat exchanger, a bubble trap-filter and disposable fluid conduits. The bubble trap-filter is located in the distal most location of the recirculating loop just upstream of the Y-connector to the patient and the air sensor just downstream of the cardiotomy reservoir in the proximal location of the recirculating loop. The experimental infuser has been safely and successfully used with patients undergoing liver transplantation, combined liver and kidney transplantation, major vascular surgery, and other operations associated with large rapid transfusion requirements.

Disposable cartridge for producing gas-enriched fluids

A device generates a gas-enriched physiologic fluid and combines it with a bodily fluid to create a gas-enriched bodily fluid. The device may take the form of a disposable cartridge. The cartridge may include a fluid supply chamber for delivering physiologic fluid under pressure to an atomizer. The atomizer delivers fluid droplets into a gas-pressurized atomization chamber to enrich the physiologic fluid with the gas. The gas-enriched physiologic fluid is delivered to a mixing chamber in the cartridge where the gas-enriched physiologic fluid is mixed with a bodily fluid, such as blood, to create a gas-enriched bodily fluid.

Delivery blood storing member-equipped blood reservoir tank and blood delivery instrument for extracorporeal circulation circuit

A delivery blood storing member-equipped blood reservoir tank has a blood reservoir tank portion, and a delivery blood storing member that communicates with a blood outlet formed in the blood reservoir tank portion. The delivery blood storing member allows blood to flow out of an interior thereof when pressed from outside. The delivery blood storing member reserves amounts of blood in accordance with the height of liquid surface in the blood reservoir tank portion if the amount of blood in the blood reservoir tank portion becomes equal to or less than a predetermined value. The delivery blood storing member includes a body part that is formed from a hard material, and a flexible diaphragm whose peripheral end is fixed to the delivery blood storing member body part. The diaphragm produces substantially no self-restoring force against deformation.

用于在体外循环期间人体温度控制的传热液和温度控制系统

本申请涉及一种用于在体外循环期间人体温度控制的传热液、温度控制系统、用于体外循环的传热液的应用以及使用传热液的人体温度控制方法。所述传热液可以由约25体积％至约35体积％的乙二醇或丙二醇、0.05体积％以下的过氧化氢和余量的无菌过滤去离子水组成。

이동식 인공심폐기

본 발명은, 하나 이상의 정맥혈 튜브(5), 혈액 펌프(8), 산화기(9), 동맥혈 필터(15), 동맥혈 튜브(4), 관형 혈액순환 시스템(7), 자동 제어 시스템(24) 및 자족식 전압 공급원을 가져서 심폐기능을 대신하거나 보조하므로써 혈액순환을 유지하는 이동식 인공심폐기에 관한 것이다. 인공심폐기가 간단한 방식으로 다루어질 수 있도록 하기 위해, 한편으로는 혈액을 순환시키고 생화학적인 그리고 생리적인 신호들을 수신하며 제어 명령들을 수행하는 요소들(4, 5, 6, 7, 8, 9, 15, 18, 21), 및 다른 한편으로는 구동부와 자동 제어 요소들(23, 24, 27, 28, 29, 30, 31, 32)이 두 개의 분리된 모듀울들(2, 3)내에 각각 배열되며 하나의 기능적인 유니트를 형성하기 위해 서로 결합될 수 있다.

用于透析系统的充灌系统和方法

本申请涉及能够利用透析液充灌系统的体外血液处理系统。塑料模制的紧凑歧管支撑模制的血液和透析液流体通路以及相关的传感器、阀和泵。紧凑歧管在一个实施例中还是一次性的，并且能够可拆卸地安装在透析设备中。在歧管中的双路阀用于导向透析液流动通过血液回路以充灌用于治疗的回路。

心肺バイパス回路で脈動流を発生するための方法及び装置

(57)【要約】 比例配分バルブを使用することによって、自然の脈動とぴったりと近似させた脈動する心肺流を人工心肺装置で発生し、この装置の心肺回路内の血液の一部を動脈供給ラインに搬送し、部分を動脈ポンプの上流で心肺回路内にリサイクルする。搬送される血液とリサイクルされる血液との相対的な比は、人間の心拍の波形に近似した波形に従って変化する。

人工臓器

(57)【要約】 【課題】 生細胞の機能を高く維持したまま、長期間に 亘って使用可能な、生細胞を用いる人工臓器を提供する こと。 【解決手段】 ラミニンを５０重量％以上含むマトリッ クスと、該マトリックス中に分散された生細胞と、該マ トリックス及び生細胞を収納し、外部との液体の流出入 が可能な収納体とを具備する人工臓器を提供した。

用于透析系统的充灌系统和方法

本发明涉及用于透析系统的充灌系统和方法。本申请涉及能够利用透析液充灌系统的体外血液处理系统。塑料模制的紧凑歧管支撑模制的血液和透析液流体通路以及相关的传感器、阀和泵。紧凑歧管在一个实施例中还是一次性的，并且能够可拆卸地安装在透析设备中。在歧管中的双路阀用于导向透析液流动通过血液回路以充灌用于治疗的回路。

用于将流体袋附接至用于体外血液处理的系统的流体加温器的附接组件

本发明涉及用于将流体容器附接至用于体外血液处理的系统的流体加温器的附接组件，所述组件包括：至少一个钩形固定装置，位于所述流体加温器上；至少一个销形固定装置，位于所述流体加温器上；以及至少两个接收构件，位于所述流体容器上，用来接收位于所述流体加温器上的所述至少一个钩形固定装置和所述至少一个销形固定装置。本发明的另一方面涉及流体加温器，其特征在于包含：至少一个钩形固定装置，位于所述流体加温器上；以及至少一个销形固定装置，位于根据本发明的流体袋附接组件的所述流体加温器上。存在于所述流体加温器上的管道引导装置结合附接至所述流体袋的不同长度的管道减少在将所述流体袋插入至所述流体加温器中期间发生使用错误。

혈액투석 시스템

본 발명은 일반적으로 혈액투석을 더 효율적이고, 쉽고, 및/또는 더 적절한 가격으로 만드는 다양한 시스템과 방법을 포함하는 혈액투석 및 유사한 투석 시스템에 관한 것이다. 본 발명의 일 태양은 일반적으로 유체 유동을 위한 새로운 유체 회로에 관한 것이다. 실시예의 일 세트에서, 혈액투석 시스템은 혈류 통로와 투석액 유로를 포함할 수 있고, 투석액 유로는 하나 이상의 균형 회로, 혼합 회로, 및/또는 지시 회로를 포함한다. 일부 경우에, 회로를 준비함으로써 투석액을 준비하는 것은 환자 투석과 분리될 수 있다. 일부 경우에, 회로는 적어도 부분적으로 하나 이상의 카세트 내에 형성될 수 있고, 선택적으로는 도관, 펌프 등과 상호연결된다. 일 실시예에서, 유체 회로 및/또는 다양한 유체 유로는 혈액투석 시스템의 전기 부품으로부터 공간적으로 및/또는 열적으로 적어도 부분적으로 고립될 수 있다. 일부 경우에, 기체 공급원은 투석액 유로 및/또는 투석기와 유체 연통하게 될 수 있고, 작동될 시, 투석액이 투석기를 통과하도록 가압하고 혈류 통로 내의 혈액이 환자에게 되돌아가도록 가압할 수 있다. 이러한 시스템은, 예를 들어, 환자에게 가능한 많은 혈액을 되돌려주는 것이 요구되는 임의의 응급 상황(예를 들어, 정전)에서 유용할 수 있다. 또한, 본 발명의 다른 태양에서, 혈액투서 시스템은 공기와 같은 제어 유체를 사용하여 작동될 수 있는 펌프, 밸브, 혼합기 등과 같은 하나 이상의 유체 취급 장치를 포함할 수 있다. 일부 경우에, 제어 유체는 임의의 경우에 탈거 가능한 외부 펌프 또는 기타 장치를 사용하여 유체 취급 장치로 이송될 수 있다. 일 실시예에서, 하나 이상의 유체 취급 장치는 일반적으로 강성이며(예를 들어, 구상 형상을 갖음), 선택적으로는, 장치를 제1 격실과 제2 격실로 나누는 다이어프램을 장치 내부에 포함한다.

Extracorporeal blood treatment and method for checking connection of the soft bag in vitro in blood processor

一种体外血液处理装置(1)和检查软袋(30，24；33，34)在装置(1)中的连接的方法。装置(1)包括血液处理装置(2)、体外血液回路(3，5)和流体回路(8，12，15，17，18，22；41，42，44)。控制单元(32)被设置为通过以下步骤检查软袋(30，24；33，34)到体外血液回路(3，5)或到流体回路(22；41，42，44)的连接：通过装置(1)的血液泵(6)或流体泵(23；37，39)从连接区(29)吸取介质；通过至少一个压力传感器(25，26)测量体外血液回路(3，5)中或流体回路(22；41，42，44)中随时间的至少一个压力趋势(P1，P1–P2，P2–P1，Pwdr，Pwdr–Pret，Pret–Pwdr)；从测量的压力趋势(P1，P1–P2，P2–P1，Pwdr，Pwdr–Pret，Pret–Pwdr)确立在连接区(29)处软袋(30，24；33，34)是否连接到体外血液回路(3，5)或流体回路(22；41，42，44)。

ORTATIVE DIALYSIS DEVICE WITH AN IMPROVED HEATING SYSTEM FOR TANKS

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2015 122 432 A (51) МПК A61M 1/16 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2015122432, 20.12.2013 (71) Заявитель(и): ФРЕЗЕНИУС МЕДИКАЛ КЕА ХОЛДИНГС, ИНК. (US) Приоритет(ы): (30) Конвенционный приоритет: 24.12.2012 US 13/726,457 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 24.07.2015 R U (43) Дата публикации заявки: 27.01.2017 Бюл. № 03 (72) Автор(ы): ФУЛКЕРСОН Барри Нейл (US), ХУАН Алек (US), КЕЛЛИ Брайан Томас (US), НОЛАН Тэм (US) (86) Заявка PCT: (87) Публикация заявки PCT: WO 2014/105755 (03.07.2014) R U (54) ОРТАТИВНЫЙ ДИАЛИЗНЫЙ АППАРАТ С УЛУЧШЕННОЙ СИСТЕМОЙ ОБОГРЕВА РЕЗЕРВУАРОВ (57) Формула изобретения 1. Диализный аппарат, имеющий блок резервуаров, при этом упомянутый блок резервуаров содержит: a. первый корпус, имеющий наружную поверхность и внутреннюю поверхность и задающий первый объем, выполненный с возможностью удерживать жидкость; b. второй корпус, имеющий наружную поверхность и внутреннюю поверхность и задающий второй объем, выполненный с возможностью размещать первый корпус с пространством между наружной поверхностью первого корпуса и внутренней поверхностью второго корпуса; c. нагревательный элемент, позиционированный в пространстве между наружной поверхностью первого корпуса и внутренней поверхностью второго корпуса; и d. первое множество электрических контактов, присоединенных к наружной поверхности второго корпуса и электрически соединенных с нагревательным элементом. 2. Диализный аппарат по п. 1, в котором упомянутый первый корпус сплавляется с упомянутым вторым корпусом. 3. Диализный аппарат по п. 1, в котором упомянутый нагревательный элемент представляет собой нагревательную подушку, и при этом упомянутая нагревательная подушка имеет диапазон номинальной мощности 300-600 Вт. 4. Диализный аппарат по п. 3, в котором упомянутая нагревательная подушка выполнена с возможностью нагревать от 1 до 6 л жидкости, расположенной в Стр ...

Apparatus and method for cardiac pause delivery

(57)【要約】 チューブ束からなる移送装置を作るための装置及び方法。移送装置は例えば血液心臓一時停止用回路における熱交換器として使用するのに適する。装置は巻き付けコアのまわりで可撓性のチューブを軸方向に巻き付ける。装置は巻き付けコアと、コア回転手段と、チューブボビンとコアのまわりでチューブを案内するチューブシャトルとを有する。シャトル回転手段はコアのまわりでチューブシャトルを回転させる。移送装置を作る方法は巻き付けコアを提供する工程と、巻き付けコアのまわりで端から端までチューブを巻き付ける工程と、ハウジング内に巻かれた束を嵌める工程と、ポッチング材料を使用してハウジングの第１及び第２の端部をシールする工程と、チューブ内の管腔を露出させるように束の端部を切断する工程と、第１の端キャップ及び第２の端キャップを取り付ける工程とを有する。

Blood pumping installations

公开一种血液泵送装置(1)，其包括至少第一泵(2)和第二泵(3)以及用于引发身体循环系统中的血液流动的第一和第二泵致动装置。每个泵(2、3)包括具有入口通道(10)的一个上部腔(9)和具有出口通道(13)的一个下部腔(12)。上部和下部腔(9、12)被可移动的阀平面(7)分开，该阀平面设有阀(14)。泵致动装置被配置成响应于来自控制单元的控制信号使阀平面(7)沿向上和向下方向在上部和下部腔(9、12)之间移动，从而使得当阀平面(7)沿向上方向移动时，设置在阀平面(7)中的阀(14)处于打开位置，容许血液从上部腔(9)流到下部腔(12)，并且当阀平面(7)沿向下方向移动时，阀(14)处于关闭位置并且血液通过出口通道(13)从下部腔(12)喷射出。下部腔(12)的底部设有袋形部分(20)。

Apparatus for treating whole blood comprising concentric cylinders defining an annulus therebetween

Apparatus for removing substances from blood is disclosed. The apparatus includes concentric cylinders defining an annulus therebetween with the inner cylinder adapted for rotation with respect to the outer cylinder. At least one of the cylinders includes a porous membrane covered portion forming a compartment containing an immobilized active species. The active species is adapted to break down or remove the substance. Plasma in blood flowing in the annulus passes through the porous membrane and interacts with the active species either by reaction or binding. Red and white blood cells do not pass through the membrane. In this way, a substance is removed from plasma without exposing blood cells to the active species.

System and method are charged for dialysis system

本发明涉及用于透析系统的充灌系统和方法。本申请涉及能够利用透析液充灌系统的体外血液处理系统。塑料模制的紧凑歧管支撑模制的血液和透析液流体通路以及相关的传感器、阀和泵。紧凑歧管在一个实施例中还是一次性的，并且能够可拆卸地安装在透析设备中。在歧管中的双路阀用于导向透析液流动通过血液回路以充灌用于治疗的回路。

Blood purification device

血液净化装置(1)包括：蠕动型的液体供给泵(24，64，74)，该液体供给泵设置在血液回路(2)或液体供给管线(4)上；蠕动型的排液泵(5)；作为水平衡量检测部的除水量检测部(10)，其检测供给液和排液的水平衡量；作为水平衡量控制部的除水量控制部(92)，其按照通过已检测的水平衡量与目标水平衡量一致的方式，对液体供给泵(24，64，74)和排液泵(51)的泵速度进行校正，其中，除水量控制部(92)按照下述的方式构成，该方式为：可切换每当检测到水平衡量时对泵速度进行校正的第1校正条件，与根据多个水平衡量的检测结果而对泵速度进行校正的第2校正条件。

Biological fluid delivery system

A cardioplegia system for delivering cardioplegic solution to the heart during open heart surgery in cooperation with an extracorporeal blood circuit employing a heart/lung machine, includes a conduit diverting a portion of the blood flow from the heart/lung machine to a cardioplegia delivery line. A heat exchanger assembly including a heat exchanger for controlling fluid temperature is provided in the cardioplegia delivery line. In addition to a heat exchanger, the heat exchanger assembly includes an integral bubble trap, filtration means and means to enable the measurement of certain physical characteristics of the circulating cardioplegia fluid and/or certain events occurring within the heat exchanger assembly.

Float-driven lever arm for blood perfusion air removal device

An air removal device removes air from blood flowing in a perfusion system. A chamber is provided having a blood flow region at a lower end thereof and having an air collection region at an upper end thereof. The chamber further has an inlet, a blood outlet, and an air outlet vertically higher than the inlet. There is a vertical guide structure in the air collection region. A float is disposed for vertical movement following the vertical guide structure, wherein the float has an effective density less than the density of blood. A lever arm having a first end follows vertical movement of the float and has a second end pivotally mounted at a pivot point that is stationary with respect to the vertical guide structure. A valve is coupled to the air outlet and to an intermediate point of the lever arm for closing the air outlet when the float is at its vertically highest position.

System for extracorporeal circulation of blood

ABSTRACT OF THE DISCLOSURE An extracorporeal blood circulation system including a line for withdrawing the venous blood from the patient, an artificial lung provided on the line, a reservoir for the blood withdrawn, a blood supply line for sending out the blood from the reservoir to the artery of the patient, and a blood supply pump provided on the blood supply line and serving as an artificial heart. The amount of blood to be supplied is automatically controlled to maintain the arterial pressure of the patient in a suitable required range. The blood supply pump is stopped when the arterial pressure of the patient measured is above a predetermined upper limit value, while the pump is driven when the arterial pressure has lowered to a level below a lower limit value. The amount of blood to be withdrawn is also controlled automatically to keep the central venous pressure of the patient approximately constant. The blood withdrawing line has a blood withdrawing pump. The reservoir is connected to the inlet side of this pump by a shunt line having a valve which is usually opened. The valve is closed when the central venous pressure exceeds a predetermined upper limit level. A vertical overflow tube detects the central venous pressure exceeding the upper limit level.

Apparatus for extracorporeal treatment of blood and method of control of a blood-warming device in an extracorporeal blood treatment apparatus

一种体外血液处理设备(1)，包括控制单元(10)，所述控制单元可连接到血液加温装置(200)并被配置为发出用于该血液加温装置的控制信号，其中所述控制信号包括命令，该命令取决于所识别的这血液处理设备的当前操作模式以将一操作模式施行血液加温装置(200)。还公开了一种用于控制血液处理设备(1)的方法以及包括血液处理设备(1)和血液加温装置(200)的装配件。

Implantable heart assist system and method of applying same

An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and methods of using same. One embodiment provides a vascular graft that has a first end that is sized and configured to couple to a non-primary blood vessel and a second end that is fluidly coupled to a pump to conduct blood between the pump and the non-primary blood vessel. An outflow conduit is also provided that has a first end sized and configured to be positioned within the same or different blood vessel, whether primary or non-primary, through the vascular graft. The outflow conduit is fluidly coupled to the pump to conduct blood between the pump and the patient. The vascular graft may be connected to the blood vessel subcutaneously to permit application of the extracardiac pumping system in a minimally-invasive procedure.

Dual heating device and method

一种双通道流体温度控制装置，通过使用来自具有功率极限的方便电源插座的功率，在手术过程中控制心脏流体的温度。第一泵接收第一热交换流体以便在第一循环通道内可选择地抽吸第一热交换流体。第二泵接收第二热交换流体以便在第二循环通道内可选择地抽吸第二热交换流体。第一加热器单元包括第一多个独立可启动加热元件，上述每个加热元件具有各自的功率消耗。第二加热器单元包括第二多个独立可启动加热元件，上述每个加热元件具有各自的功率消耗。控制器可选择地启动第一和第二泵以及第一和第二多个加热元件，以便可选择地加热或冷却第一和第二热交换流体，使得所有启动的泵和加热元件的功率引出维持在功率极限之内。

Support device for surgical system

(57)【要約】 心肺バイパス回路構成要素などの相互関連した医療構成要素を支持してディスプレイするためのデバイス。このデバイスは、その中にこの構成要素を受容するための開口を有する剛性または可撓性のシャーシを含む。ストラップ、フック、またはタブなどの複数のリテーナが、解放可能にこの構成要素をこの中に固定するようにこの開口に隣接して提供される。このシャーシは、その中にカットされたタブを有する、薄い、可撓性のポリマーシートから形成され得、多様な構成要素を保持するためにこのシートの平面から撓曲され得るように適合され得る。この構成要素の近接した事前配列は、特定の医療回路をセットアップする作業を非常に簡単化し、間違いの可能性を減少させる。心肺バイパス回路のために、この支持デバイスは、チュービング長が減少されることを可能にし、従って回路のプライミング容量を減少させる。

BLOOD CLEANING MATERIAL

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2019 105 602 A (51) МПК A61M 1/36 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2019105602, 08.09.2017 (71) Заявитель(и): ТОРЭЙ ИНДАСТРИЗ, ИНК. (JP) Приоритет(ы): (30) Конвенционный приоритет: 09.09.2016 JP 2016-176289 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 09.04.2019 R U (43) Дата публикации заявки: 09.10.2020 Бюл. № 28 (72) Автор(ы): КАНДА, Сунго (JP), ТАКАХАСИ, Хироси (JP), ТОМИТА, Наотоси (JP) (86) Заявка PCT: (87) Публикация заявки PCT: WO 2018/047929 (15.03.2018) A Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, стр. 3, ООО "Юридическая фирма Городисский и Партнеры" R U (57) Формула изобретения 1. Материал для очистки крови, содержащий нерастворимый в воде материал, в котором лиганд, имеющий группу (группы) амида и группу (группы) амина, связан с подложкой, в котором содержание группы (групп) амида составляет 3,0-7,0 ммоль на 1 г сухого веса нерастворимого в воде материала; и в котором содержание группы (групп) амина составляет 1,0-7,0 ммоль на 1 г сухого веса нерастворимого в воде материала. 2. Материал для очистки крови по п. 1, в котором лиганд, имеющий структуру, представленную нижеприведенной Формулой (I), связан с подложкой: (где X - аминогруппа; а волнистая линия показывает положение, в котором лиганд связывается с подложкой). 3. Материал для очистки крови по п. 1 или 2, в котором лиганд имеет группу фенила, Стр.: 1 A 2 0 1 9 1 0 5 6 0 2 (54) МАТЕРИАЛ ДЛЯ ОЧИСТКИ КРОВИ 2 0 1 9 1 0 5 6 0 2 JP 2017/032397 (08.09.2017) и лиганд, имеющий структуру, представленную нижеприведенной Формулой (II), связан с подложкой: A 2 0 1 9 1 0 5 6 0 2 R U A 2 0 1 9 1 0 5 6 0 2 R U (где X - аминогруппа; A - мостик; B - атом водорода или атом галогена; а волнистая линия показывает положение, в котором лиганд связывается с подложкой); и в котором содержание группы фенила составляет больше чем 0 ммоль и не больше чем 7,0 ммоль на 1 г сухого веса ...

Method and system for externally treating the blood

A chemical agent is disclosed which is useful for reducing the population of a selected blood constituent having receptor sites. The chemical agent includes a carrier having a strong affinity for the receptor sites on the blood constituent and a photoactive agent physically incorporated within or chemically bound to the carrier moiety which interferes with the metabolism of the selected blood constituent when activated by UV radiation. The photoactive agent may be a photocytotoxin selected from the group consisting of psoralen, pyrene, cholesteryloleate, acridine, porphyrin, fluorescein, rhodamine, 16-diazocortisone, ethidium, transistion metal complexes of bleomycin, transition metal complexes of deglycobleomycin and organoplatinum complexes.

Method and system for externally treating the blood

A method and system are disclosed for externally treating human blood, with the objective of reducing the functioning lymphocyte population in the blood system of a human subject. According to the method, blood is withdrawn from the subject and passed through an ultraviolet radiation field in the presence of a dissolved photoactive agent capable of forming photo-adducts with lymphocytic-DNA, mobile hormonal hormonal receptors or antigen sites to thereby effect covalent bonding between the photoactive agent and the same, thereby inhibiting the metabolic processes of the lymphocytes or complexing them; and thereupon returning the irradiated blood to the subject. The withdrawn blood may be formed into an extracorporeal stream and flowed through a treatment station whereat the irradiation is effected, as for example by exposure to UV radiation; and such flow process may be conducted on a continuous basis. If desired, the blood to be treated may be separated to provide a blood fraction rich in lymphocytes and low in any blood component which absorbs UV radiation, as for example by continuous centrifuging which fraction is then irradiated with UV radiation in the presence of a dissolved photoactive chemical agent.

Antiviral method, agents and apparatus

A method of treating a body fluid which is to be infused so as to inactivate any enveloped viruses in said fluid comprises mixing the body fluid with an effective amount of a photosensitizing agent which will bind to the viruses and/or virus infected cells and photosensitize them, and then exposing the resulting mixture to visible light to excite and inactivate the viruses. An apparatus for use in the method includes at least one container which contains an effective amount of the photosensitizing agent and which has at least one wall which is permeable to visible light. A number of photosensitizing agents which can be used in the method also are disclosed.

Attachment assembly for the fluid warmer that fluid pouch is attached to the system for extracorporeal blood treatment

本发明涉及用于将流体容器附接至用于体外血液处理的系统的流体加温器的附接组件，所述组件包括：至少一个钩形固定装置，位于所述流体加温器上；至少一个销形固定装置，位于所述流体加温器上；以及至少两个接收构件，位于所述流体容器上，用来接收位于所述流体加温器上的所述至少一个钩形固定装置和所述至少一个销形固定装置。本发明的另一方面涉及流体加温器，其特征在于包含：至少一个钩形固定装置，位于所述流体加温器上；以及至少一个销形固定装置，位于根据本发明的流体袋附接组件的所述流体加温器上。存在于所述流体加温器上的管道引导装置结合附接至所述流体袋的不同长度的管道减少在将所述流体袋插入至所述流体加温器中期间发生使用错误。

Movable heart-lung machine

本发明提供了一种心肺机，所述心肺机可由一个人携带并可独立于外部电源使用，所述心肺机包括至少三个模块(1、2、3)，其特征在于，第一模块(1)包含心肺机功能所需的血液循环元件，第二模块(2)包含泵驱动(9)和电子测量装置和控制逻辑(11)，并且第三模块(3)包含编程装置(14)，而第二单元可分离地连接于第一和第三模块。

Method and apparatus for continuous separation of blood in vivo

Peripheral cardiopulmonary bypass and coronary reperfusion system

A method and apparatus to arrest or reverse heart damage from myocardial infarction by using a peripheral, femoral-femoral full bypass along with the venting of the left ventricle wherein the rate at which blood is drawn from the femoral vein and the rate at which the left ventricle is vented are related in a predetermined manner. The damaged area is treated with a cardioplegic solution; the blockage causing the heart attack is then removed by a thrombolytic solution or by angioplasty, while blood is prevented from entering the ventricle and from reactivating the heart from its at-rest condition. Normal blood flow is then restored, and the various catheters and bypass mechanisms removed. The system is also useful for peripheral cardiopulmonary bypass systems not involving the application of a cardioplegic solution. The catheters are specially designed for their function.

Organic liquid oxygenator

FIELD: medical equipment. SUBSTANCE: invention relates to medical equipment, namely to an organic liquid oxygenator (1; 100). The oxygenator (1; 100) comprises a container body (2) with a longitudinal axis (A). The oxygenator (1; 100) has a first inlet (3) for oxygen and a second outlet (4) for the exhaust gas produced in the above container body (2). The oxygenator (1; 100) includes a third inlet (5) for the organic fluid medium subject to oxygenation and a fourth outlet (6) for the organic fluid medium subjected to oxygenation and produced in the above container body (2). The oxygenator (1; 100) has an oxygenation chamber (7) for the above fluid subject to oxygenation, located in the above container body (2). The oxygenator (1; 100) includes a distribution pre-chamber (17) for the fluid subject to oxygenation between the third inlet (5) and the above oxygenation chamber (7). The oxygenator (1; 100) has multiple capillary fibres (8), permeable to liquids and porous to gases, configured to cover said fibres with said organic liquids and secured by means of securing means (28) inside said oxygenation chamber (7) in accordance with a general parallel direction. The oxygenator (1; 100) comprises a dynamic distribution apparatus (24) supported in said distribution pre-chamber (17) by means of a bearing (20). Said set of capillary fibres (8) is collected into a package containing coils of adjacent layers (S) of fibres arranged transversely relative to said longitudinal axis (A) and located between at least two perforated flat plates (14, 15) located parallel to each other in said oxygenation chamber (7). Lining elements (11) are located between said layers (S). Said lining elements comprise sheets (11) of a double-sided adhesive material, completely enclosed in a plastic-polymer element or a so-called filling (28). At least a central cylindrical used section (Ω1) is located perpendicularly between said adjacent layers (S), coaxial with said longitudinal axis (A), ...

Materials for blood purification

본 발명은 사이토카인 및 활성화 백혈구-활성화 혈소판 복합체의 제거 성능을 갖는 혈액정화용 재료를 제공하는 것을 목적으로 하고 있다. 본 발명은 기재에 아미드기와 아미노기를 갖는 리간드가 결합한 수불용성 재료를 포함하고, 상기 아미드기의 함량은 상기 수불용성 재료의 건조중량 1g당 3.0∼7.0mmol이며, 상기 아미노기의 함량은 상기 수불용성 재료의 건조중량 1g당 1.0∼7.0mmol인 혈액정화용 재료를 제공한다.

APPARATUS AND METHOD OF CONTROL IN A BLOOD EXTRACORPOREAL CIRCUIT

Device and method during extracorporeal blood treatment

Eine Vorrichtung bei extrakorporaler Blutbehandlung beinhaltet ein Bilanzierungssystem und berechnet ein Ultrafiltrationsvolumen (UF D ) als einen Volumenentzug auf Grundlage einer Druckdifferenz (” P ) und einer Temperaturdifferenz (” T ) an einem Zulauf und einem Ablauf zumindest zweier Bilanzkammern (1, 2). Dazu sind ein erster Drucksensor (30) und ein zweiter Drucksensor (40) jeweils direkt hinter einem Zulauf bzw. Ablauf von zwei Bilanzkammern (1, 2) angeordnet und bestimmen einen Fluiddruck an jeweils ihrer Position, und sind ein erster Temperatursensor (60) und ein zweiter Temperatursensor (70) an Eingängen der zumindest zwei Bilanzkammern (1, 2) angeordnet und bestimmen eine Temperatur im Zulauf und im Ablauf der Bilanzkammer. Das Ultrafiltrationsvolumens (UD F ) wird unter Verwendung der Druckdifferenz (” P ), die auf Grundlage von durch den ersten Drucksensor (30) und den zweiten Drucksensor (40) bestimmten Fluiddruckwerten ermittelbar ist, und der Temperaturdifferenz (” T ), die auf Grundlage von durch den ersten Temperatursensor (60) und den zweiten Temperatursensor (70) bestimmten Temperaturwerten ermittelbar ist, berechnet. A device for extracorporeal blood treatment includes a balancing system and calculates an ultrafiltration volume (UF D ) as a volume withdrawal based on a pressure difference ("P") and a temperature difference ("T") at an inlet and an outlet of at least two balancing chambers (1, 2). For this purpose, a first pressure sensor (30) and a second pressure sensor (40) are each arranged directly behind an inlet or outlet of two balancing chambers (1, 2) and determine a fluid pressure at their respective positions, and a first temperature sensor (60) and a second temperature sensor (70) is arranged at the inputs of the at least two balance chambers (1, 2) and determines a temperature in the inlet and outlet of the balance chamber. The ultrafiltration volume (UD F ) is calculated using the pressure difference ("P"), ...

Systems or apparatuses and methods for performing dialysis

The invention provides a method and an apparatus or system for dialysis. The method and apparatus or system are useful for removing an undesirable protein-binding substance such as a toxin from a biological fluid such as blood or blood plasma. As such, the method and apparatus or system are useful for treating a subject in need of dialysis such as a subject suffering from hepatic disease. The methods feature a) dialyzing a biological fluid against a dialysis fluid containing an adsorber for a protein-binding substance to be removed through a semipermeable membrane, b) adjusting the dialysis fluid so that the binding affinity of the adsorber for the protein-bound substance to be removed is lowered and the substance to be removed passes into solution, and c) balancing the volume or flow of one or more fluids in the apparatus or system suitable for dialyzing a biological fluid containing a protein-binding substance to be removed. The apparatus or system features a) a biological fluid circuit (3); b) a dialysis fluid circuit (2); c) a means (4; 6; 7; 8; 9) for solubilizing the protein- binding substance to be removed; d) a dialysis, filtration or diafiltration device (5); e) a balancing system or apparatus suitable for balancing the volume or flow of one or more fluids in the apparatus or system suitable for dialyzing a biological fluid containing a protein-binding substance to be removed; and f) a dialysate regeneration unit.

Apparatus for treating blood in an extracorporeal circuit

An apparatus for treating blood in an extracorporeal circuit for hemodialysis of hemofiltration and a method for withdrawing heat from blood in an extracorporeal circuit wherein blood is brought into contact along a membrane with a treatment solution which has been heated to a temperature in a source making the treatment of fluid available such that the energy balance of the patient is maintained, the temperature of the source being controlled in that the temperature of the blood emerging from the patient is measured, the temperature value obtained is compared with a predetermined temperature value and on determination of a difference between the two values the source temperature is changed.

Hemofiltration system and method

A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. The system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results.

Computer-control medical care system

A computer-controlled medical care system for use in the treatment and diagnosis of patients provides for either automatic or manual control of a wide variety of medical procedures including diagnostic procedures. The system accepts modular vessel structures, each type of structure being adapted for carrying out a specific procedure and matching programs for carrying out the specific procedures. A microcomputer accepts a program which may be designed to fit the needs of a specific patient and which must watch the modular vessel structure. The microcomputer monitors the progress of the process and the physiological status of the patient and provides for the taking of appropriate steps should difficulties be encountered in carrying out the procedure. The system can also be programmed to analyze a fluid taken from an individual, to treat the fluid and return same to the individual and to schedule the infusion of appropriate medications. Embodiments of the system provide for carrying out only a limited group of procedures where a full-range system is undesirable either because unnecessary or uneconomic. Modular vessel structures are keyed to specific programs, thereby preventing operator errors and increasing the reliability of the system.

Hemofiltration system and method

A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. The system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results.

Hemofiltration system and method

Hemofiltration system and method