ПОДГОТОВИТЕЛЬНАЯ АНТИКОАГУЛЯНТНАЯ ЛИНИЯ ДЛЯ ЗАБОРА КРОВИ

Группа изобретений относится к медицинской технике. Способ уменьшения собранного объема во время сбора компонентов крови включает подготовку и регулировку оборудования по переработке крови антикоагулянтным раствором, включая синхронное закачивание антикоагулянта до обнаружения датчиком в заборной/возвратной линии. Далее подтверждают операции закачивания и геометрической конфигурации трубопровода путем сравнения количества оборотов двигателя насоса, необходимого для продвижения антикоагулянтного раствора между воздушными/жидкостными датчиками к заданным ожидаемым результатам на основе известной производительности насоса и длины трубопровода. Подтверждают надлежащую функцию насосов и колпачка на устройстве венозного доступа путем удерживания одного насоса в фиксированном состоянии и перемещения другого при сравнении наблюдаемого изменения давления на датчике давления с ожидаемым изменением на основе соотношения объема жидкости с воздухом, ожидаемого в линиях. Уведомляют оператора о любых ...

KALIBRIERUNG MEHRERER PUMPEN EINES FLÜSSIGKEITSSTRÖMUNGSSYSTEMS

Method of removing blood from extracorporeal blood circulation for treatment device for extracorporeal blood treatment of patient after completing blood treatment session, involves introducing substitute fluid in extracorporeal circulation

The method involves introducing substitute fluid in an extracorporeal circulation (1000). The substitute fluid is conveyed for simultaneous discharge of blood both from an arterial line section (1) and from a venous line section (3) of the extracorporeal blood circulation. The blood is conveyed under simultaneous operation of a blood pump (13) and a conveyor from the extracorporeal circulation. Independent claims are also included for the following: (1) a treatment device with a storage unit; and (2) a tubing system for use in blood removing method.

Kombinierter Halter und Anschluss für einen Dialysator

KUENSTLICHE LUNGE VOM HOHLFASERTYP.

Dialysevorrichtung und Verfahren zum Reinigen und Befüllen derselben

Method of operating fluid flow transfer apparatus

A fluid flow chamber cassette that can be mounted with either its front wall or rear wall against a supporting machine and has a flexible tube that extends from a sidewall and forms a loop that is symmetrical about a loop axis that is transverse to the side wall so that the loop will be acted upon by a pump roller on the machine both when the front wall is against the machine and when the rear wall is against the machine. Also disclosed is automatically fixing the initial liquid levels and amounts of air in venous and arterial chambers of fluid flow transfer device apparatus by having the arterial chamber inlet enter the arterial chamber at a position higher than the arterial chamber outlet, having the venous chamber inlet enter the venous chamber at a position higher than the venous chamber outlet, and priming the apparatus by causing reverse flow, so that the liquid rises in the venous and arterial chambers to the level of the entrances of the inlets. Also disclosed is sensing pressure ...

Modular home dialysis system - debubblers

An apparatus for removing air bubbles from blood is disclosed. The debubbler comprises front and rear covers (1002, 1008 respectively) with a fluid circuit board (1004) arranged between the two covers. A blood chamber is defined between cover (1002) and circuit board (1004) and an air chamber is defined between covers (1008) and circuit board (1004). A microporous membrane (1006) separates the blood and air chambers. A support means (1024) supports membrane (1006) from the air side of the membrane. A blood pressure sensor is provided between covers (1002, 1008). The debubbler has a blood inlet port (1022) and a blood outlet port (1020) for conducting blood to and from the blood chamber. An air port (1012) is provided in communication with the air chamber, to allow air passing through membrane (1006) to escape.

Modular home dialysis system

DEVICE FOR THE SUPPLY A EXTRAKORPORALEN OF A BLUTKREISLAUFS

ARRANGEMENT FOR ON-LINE RINSING AND FILLING OR FREE RINSES A EXTRAKORPORALEN OF A BLUTKREISLAUFS OF DIALYSIS MACHINES

PROCEDURE FOR EMPTYING A BLUTKREISLAUFS IN A DEVICE FOR EXTRAKORPORALEN THE BLOOD TREATMENT

BLOOD TREATMENT EQUIPMENT AND PROCEDURE FOR EMPTYING ONE BLUTSCHLAUCHSATZES BLOOD TREATMENT EQUIPMENT

PROCEDURE FOR ON-LINE RINSING AND FILLING A EXTRAKORPORALEN OF A BLUTKREISLAUFES OF DIALYSIS MACHINES

PROCEDURE AND DEVICE FOR THE FLUSHING OF A DIAPHRAGM APPARATUS

CARTRIDGE FOR STEERING AND PUMPING FLUIDS

PROCEDURES FOR CALIBRATING A IN OF A PERISTALTI PUMP USED PUMPING SEGMENT AS WELL AS MEDICAL MACHINE TO THE EXECUTION OF THE PROCEDURE

Single needle recirculation system for harvesting blood components

UNITARY HEAT EXCHANGER AND DEBUBBLER

Automatic priming and scheduling for dialysis systems

A method including automatically performing at least one integrity test on a dialysis machine after powering on the dialysis machine, wherein the at least one integrity test is selected from the group consisting of a battery test, a dialysate conductivity test, and a dialysate temperature test. The method also includes presenting, on a display of the dialysis machine, a first set of instructions for priming the dialysis machine after completing the at least one integrity test.

Method for filling and rinsing a set of blood lines

The invention relates to a method for filling and rinsing a set of blood lines, comprising a pump segment for a blood pump, an arterial line connected to an input of a dialysis machine and a venous line connected to the output of a dialysis machine, by means of a substitute line. Said method comprises the steps of connecting the arterial line to the venous line and connecting both lines to a rinse port, connecting the substitute line to a substitute port, opening the rinse port, filling the arterial and venous line, rinsing the arterial and venous line, closing the rinse port, circulating the substitute in the circuit of arterial line, dialysis machine, and venous line by means of the blood pump, characterised in that the filling and/or rinsing of the venous and the arterial line occurs simultaneously wherein substitute is introduced from the substitute line. The invention further relates to a set of blood lines.

Hemodial ysis system

A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly.

Hemodial ysis system

A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly.

Method and apparatus for priming an extracorporeal blood circuit.

A method and apparatus for priming an extracorporeal blood circuit, in which the patient end of an arterial line (79) is connected to a first discharge port (61), and the patient end of a venous line (87) is connected to a second discharge port (62). The two discharge ports are connected to a used dialysate line which connects a dialyser (33) to a drain. The arterial and venous lines are filled with a priming fluid, while the air contained in the arterial and venous lines is evacuated partly through the first discharge port and partly through the second discharge port. Two check valves (65, 66) prevent flow from the used dialysate line towards the two discharge ports. The invention reduces the risk of errors on the part of an operator readying the priming configuration, as well as the risk of contamination of the extracorporeal circuit during the priming phase.

Automatic priming of blood sets

Priming system and method for dialysis systems

HEAT STERILIZATION METHOD FOR ARTIFICIAL ORGAN ASSEMBLIES

PERSONAL HEMODIALYSIS SYSTEM

A dialysis machine includes a dialysis instrument having a pump actuator and first and second valve actuators, and a disposable cassette operable with the dialysis instrument, the disposable cassette including a pump portion operable with the pump actuator, first and second valve chambers operable with the first and second valve actuators, the first and second valve chambers communicating fluidly with each other, at least the first valve chamber communicating fluidly with a compliance chamber, the compliance chamber negating a first backpressure due to a pneumatic closing pressure used to close the first valve chamber to help to ensure the pneumatic pressure applied to the first valve chamber will close the first valve chamber against a second backpressure from an existing closure of the second valve chamber.

PUMP MONITOR FOR PHOTOACTIVATION PATIENT TREATMENT SYSTEM

PUMP MONITOR FOR PHOTOACTIVATION PATIENT TREATMENT SYSTEM A preferred patient blood treatment system for the photoactivation of reagents in contact with a patient's blood employs an infusion pump for adding anti-coagulation reagent to the blood during extracorporeal operations. The infusion pump is preferably driven by a stepper motor and monitored by a periodic photo chopper employing a plurality of sensors. The spacing of the sensors and the spacing of the photo choppers work in concert to detect rotation of the stepper motor and to discriminate such from stutter or other characteristic nonrotational faults associated with stepper motors.

MODULAR BLOOD TREATMENT SYSTEMS, UNITS, AND METHODS

A portable adapter is provided that can include a closure system configured to control the flow of blood and/or dialysate between the adapter and a blood treatment apparatus. Modular systems are also provided that include the portable adapter engaged with various units such as a portable blood processing module, a non-portable base module, and/or a remote module. Methods of conducting blood treatments such as blood circulation, hemodialysis, and hemofiltration, hemodiafiltration, using the modular systems are also provided. The systems, units, and methods enable the engagement and disengagement of the adapter from the various units to conduct, interrupt, and resume blood treatments without disconnecting the adapter from the vasculature of a patient. Modular systems including interchangeable portable and base modules configured for various blood treatments are also provided that can be engaged and disengaged with each other without disconnecting the portable module from the vasculature of ...

HEMODIALYSIS SYSTEMS AND METHODS

The present invention relates to hemodialysis and similar dialysis systems, including systems and methods that make hemodialysis more efficient, easier, and/or affordable. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air.

Single Needle Recirculation System for Harvesting Blood Components

Modular Home Dialysis System

TECHNIQUE FOR PRIMING AND RECIRCULATING FLUID THROUGH A DIALYSIS MACHINE TO PREPARE THE MACHINE FOR USE

A technique for automatically priming and recirculating sterile fluid through an extracorporeal circuit of a dialysis machine having a blood pump, a dialyzer (54), and a blood tubing set including an arterial line (38) for drawing blood from a patient and a venous line (66) for returning the blood to the patient. The dialysis machine selectively opens and closes clamps (40 and 72) on the arterial and venous lines and further operates a waste valve (106) leading to a waste drain (86). A connector (102) attaches the arterial and venous lines to the waste valve during the priming procedure. The dialysis machine automatically operates the blood pump, the clamps and the waste valve to flush the dialyzer and the blood tubing set with sterile fluid, direct the used fluid down the waste drain and recirculate additional sterile fluid through the extracorporeal circuit.

Removal of Selected Factors from Whole Blood or Its Components

INTEGRATED CASSETTE FOR VALVING, PUMPING AND CONTROLLING MOVEMENT OF FLUIDS

An apparatus controls movement of fluids during an extracorporeal blood treatment session. A hollow enclosure has a plurality of fluid input ports for receiving fluids into the enclosure and a plurality of fluid output ports for expelling fluids from the enclosure. A first roller pump tube is provided for pumping at least one of the fluids through the hollow enclosure during the photopheresis treatment session. Internal fluid passageways disposed within the hollow enclosure are provided for coupling together the fluid input ports, the fluid output ports and the roller pump. At least one internal valve is disposed within the hollow enclosure for controlling movement of the fluid within the hollow enclosure.

MODULAR HOME DIALYSIS SYSTEM

A machine for conducting dialysis of body fluids of a patient. The machine includes integral water preparation and treatment, dialysate preparation, and extracorporeal circuit modules, under computer control from a patient interface and control module. A water pretreatment module with a temperature-controlled mixing valve, an integral water filtration and conditioning unit and a pressure relief with integral water sample removal port supplies water to the machine. The dialysate preparation module includes a substantially non-compliant tank with attached batch chemical bottles and automatic chemical addition and dispersion subsystems. The machine incorporates novel automatic process control techniques to verify the status and integrity of the critical system components, ultrafiltration control, and temperature, pressure and conductivity conditions prior to dialysis.

CONTAINER FOR the WASHING and OPERATING INTEGRATION OF the OPERATION OF CIRCUITS AND FILTERS FOR DIALYSIS AND USE OF SUCH CONTAINER.

Spike with non-return valve function and filling device for a liquid system, comprising said spike

IRRIGATION SYSTEM FOR USE DURING ARTHROSCOPY

STERILE BLOOD COMPONENT COLLECTION

UNIT OF DIALYSIS INCLUDING/UNDERSTANDING A DRAIN READY TO COOPERATE IN WAY SEALS WITH TUBES.

APPARATUS OF the CASSETTE TYPE USABLE WITH a DEVICE OF TRANSFER OF FLUIDS, PROCESS Of USE Of SUCH an APPARATUS AND APPARATUS TO DETECT the PRESSURE Of a LIQUID

SYSTEM Of IRRIGATION INTENDS TO BE USES DURING a ARTHROSCOPIE

체외 혈액 회로 내 기포 제거 방법

... 본 발명은 투석 장치의 체외 혈액 회로의 목표 영역에서 기포를 제거하는 방법에 관한 것으로서, 상기 목표 영역은 유입부를 통해 상기 목표 영역으로 들어가고 유출부룰 통해 다시 목표 영역에서 빠져나가는 세정액에 의해 통과되며, 상기 유입부는 동맥 포트와 구별되고 상기 유출부는 상기 체외 혈액 회로의 정맥 포트와 구별된다. 더 나아가 본 발명은 체외 혈액 회로 및 컨트롤 유닛을 포함하는 투석 장치에 관한 것으로서, 상기 체외 혈액 회로는 세정액을 위한 유입부 및 유출부를 포함하되, 상기 유입부는 동맥 포트와 구별되고 상기 유출부는 상기 체외 혈액 회로의 정맥 포트와 구별되며, 상기 컨트롤 유닛은 본 발명에 따른 방법을 실시하기 위해 구성된다. 또한 본 발명은 상기 투석 치료를 위한 일회용기기에 관한 것으로서, 상기 일회용기기는 동맥 라인, 혈액 펌프의 구성요소들, 투석기 및 정맥 라인을 포함하되, 상기 일회용기기는 상기 동맥 라인 내에 세정액의 상기 유입부를 위한 인터페이스와 상기 정맥 라인 내에 세정액의 상기 유출부를 위한 인터페이스를 포함하고, 상기 유입부를 위한 상기 인터페이스는 동맥 포트와 구별되고 상기 유출부를 위한 상기 인터페이스는 호스 세트의 정맥 포트와 구별된다.

Extracorporeal circulation device and control method

An extracorporeal circulation device having high safety without increases in the circuit scale and the power consumption includes a main control unit responsible for control of a motor drive circuit so as to yield a blood flow rate per unit time set by a user. The motor drive circuit applies a drive signal corresponding to the set blood flow rate to a motor. A sub-control unit configured by a field programmable gate array (FPGA) detects the drive signal applied to the motor and monitors whether or not the drive signal falls within an allowable range corresponding to the set blood flow rate. If the drive signal outside the allowable range is applied, the main control unit is deemed to be in an abnormal state and the main control unit is completely stopped. Then, the sub-control unit takes over the subsequent processing.

Extracorporeal blood circuit priming system and method

A disposable, integrated extracorporeal blood circuit employed during cardiopulmonary bypass surgery performs gas exchange, heat transfer, and microemboli filtering functions in a way as to conserve volume, to reduce setup and change out times, to eliminate a venous blood reservoir, and to substantially reduce blood-air interface. Blood from the patient or prime solution is routed through an air removal device that is equipped with air sensors for detection of air. An active air removal controller removes detected air from blood in the air removal device. A disposable circuit support module is used to mount the components of the disposable, integrated extracorporeal blood circuit in close proximity and in a desirable spatial relationship to optimize priming and use of the disposable, integrated extracorporeal blood circuit. A reusable circuit holder supports the disposable circuit support module in relation to a prime solution source, the active air removal controller and other components ...

DIALYSIS SYSTEM INCLUDING CASSETTE WITH PUMPING TUBES

A hemodialysis system includes a blood treatment machine, a blood pump housed by the blood treatment machine, a first dialysate pump housed by the blood treatment machine, a second dialysate pump housed by the blood treatment machine; and a fluid cassette including an upper portion and a lower portion. The fluid cassette further includes a blood pumping tube extending from the upper portion to the lower portion of the fluid cassette, a first dialysate pumping tube extending from the upper portion to the lower portion of the fluid cassette, and a second dialysate pumping tube extending from the upper portion to the lower portion of the fluid cassette.

Method of cleaning and priming dialysis system

A dialysis system which does not need to use a physiological saline in replenishing a solution or cleaning and priming the dialysis system, does not need a troublesome setting operation and can easily and accurately set a flow rate of a replenisher solution. The dialysis system includes a closed-type water-removal control apparatus 1, a dialyzer 2, a fresh dialysate line 3 as well as a used dialysate line 4, an RO water pressurizing line 5, an RO water pressurizing pump 51 provided in the RO water pressurizing line 5, an artery side blood line 6, a blood pump 61 provided at the artery side blood line 6 and a vein side blood line 7. According to the dialysis system, by pressurizing RO water into a communication line of the used dialysate, dialysate is made to flow from a dialysate flow path 21 into a blood flow path 22 through a dialysis membrane 23 of the dialyzer 2 and the inside of a blood circulation path can be cleaned and primed.

DIALYSIS MACHINE WITH FLUID PUMPING CASSETTE

A dialysis system is disclosed. The example dialysis system includes a housing, a pump actuator housed by the housing, a fluid pumping cassette coupled operably to the housing and including a flexible membrane covering a pump chamber, and a mechanically actuated piston head provided by the pump actuator and positioned to extend towards and away from the fluid pumping cassette. The fluid pumping cassette is positioned such that the flexible membrane of the fluid pumping cassette faces the piston head so that the piston head can push the flexible membrane into the pump chamber of the fluid pumping cassette to expel a fluid from the pump chamber. The example dialysis system also includes a controller programmed to perform a leak test by monitoring a sensed position of the mechanically actuated piston head while the mechanically actuated piston head applies a force to the flexible membrane of the fluid pumping cassette. 1: A dialysis system comprising:a housing;a pump actuator housed by the housing;a fluid pumping cassette coupled operably to the housing and including a flexible membrane covering a pump chamber;a mechanically actuated piston head provided by the pump actuator and positioned to extend towards and away from the fluid pumping cassette, the fluid pumping cassette positioned such that the flexible membrane of the fluid pumping cassette faces the piston head so that the piston head can push the flexible membrane into the pump chamber of the fluid pumping cassette to expel a fluid from the pump chamber; anda controller programmed to perform a leak test by monitoring a sensed position of the mechanically actuated piston head while the mechanically actuated piston head applies a force to the flexible membrane of the fluid pumping cassette.2: The dialysis system of claim 1 , wherein the membrane is moved by the mechanically actuated piston head during the leak test if a leak is present.3: The dialysis system of claim 1 , wherein the controller is programmed to ...

Dialysis system with enhanced features

A dialysis system includes a dialysis fluid cassette-based membrane blood pump; a dialyzer in fluid communication with the blood pump: first and second dialysis fluid cassette-based balance chambers each having (i) a fresh dialysis fluid compartment in fluid communication with the dialyzer and (ii) a spent dialysis fluid compartment; a dialysis fluid cassette-based fresh dialysis fluid membrane pump in fluid communication with the fresh dialysis fluid compartments of the first and second balance chambers; a dialysis fluid cassette-based spent dialysis fluid membrane pump in fluid communication with the dialyzer and the spent dialysis fluid compartments of the first and second balance chambers; and arterial and venous lines in fluid communication with the dialyzer for patient connection, the arterial and venous lines each including a contact used for electrically detecting a patient access disconnection.

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

In an apparatus for extracorporeal blood treatment, an extracorporeal circuit (6) is connected to a blood chamber (3) of a membrane device (2). A pump (10) displaces a priming fluid from a source of a priming fluid (9) to a drainage (11) for discharging the priming fluid. A control unit (13) is provided with a processor which controls the pump at a preset first flow rate value, and receives from a pressure sensor (12) a first pressure value, compares the first pressure value with a reference pressure value and, on the basis of this comparison, determines whether or not the extracorporeal circuit is of a pediatric type or of an adult type. The invention is particularly useful during a stage of readying a dialysis apparatus.

Easily Movable Blood Purification Systems

The document describes a system which is easy to move in order to allow travelling anywhere in the world. The document provides different potential features and embodiments such as the container support, the loading system, the shape of the housing, . . .

Rotary valves for dialysis systems

In one aspect, a dialysis fluid cassette includes an inlet fluid line, multiple outlet fluid lines, and a valve including an actuation feature by which the valve can be rotated to fluidly communicate the inlet fluid line with a selected fluid line of the multiple outlet fluid lines.

Valve Actuation Systems and Related Methods

In one aspect, a valve actuation system includes a drive unit including an actuator configured to engage and move multiple valves disposed within a fluid cassette to selectively open and close each valve of the multiple valves and a positioning frame disposed adjacent the fluid cassette and along which the drive unit can be moved in three dimensions to align the actuator with a selected valve of the multiple valves.

DEVICES FOR DETERMINING A FILLING VOLUME OF AN EXTRACORPOREAL BLOOD CIRCUIT

VERFAHREN ZUM FUELLEN EINES BLUTSCHLAUCHSYSTEMS EINER HAEMODIALYSEVORRICHTUNG MIT EINER PHYSIOLOGISCHEN KOCHSALZLOESUNG SOWIE VORRICHTUNG HIERZU

Dialysemaschine

Die vorliegende Erfindung betrifft eine Dialysemaschine mit einem extrakorporalen Kreislauf, in dem sich ein Dialysator befindet, der eine von Blut durchströmte blutseitige Kammer aufweist, sowie ein in Strömungsrichtung des Blutes stromaufwärts der blutseitigen Kammer befindlicher erster Drucksensor zur Ermittlung eines ersten Druckwertes und ein in Strömungsrichtung des Blutes stromabwärts der blutseitigen Kammer befindlichen zweiter Drucksensor zur Ermittlung eines zweiten Druckwertes, wobei die Dialysemaschine erste Mittel zur Ermittlung der Druckdifferenz zwischen dem zweiten und dem ersten Druckwert aufweist, zweite Mittel zur Ermittlung der dynamischen Viskosität des Blutes basierend auf der ermittelten Druckdifferenz, der Blutflussrate durch die blutseitige Kammer und einer oder mehrerer charakteristischer Eigenschaften des Dialysators und dritte Mittel zur Ermittlung des Hämatokrits oder des Hämoglobinwertes des Blutes basierend auf der ermittelten Viskosität aufweist und wobei ...

Verfahren zum Entfernen von Blut aus einem extrakorporalen Blutkreislauf für eine Behandlungsvorrichtung nach Beenden einer Blutbehandlungssitzung und Vorrichtung zum Ausführen desselben

Vorgeschlagen wird ein Verfahren zum Entfernen von Blut aus einem extrakorporalen Blutkreislauf (1) für eine Behandlungsvorrichtung zur extrakorporalen Blutbehandlung eines Patienten (3) nach Beenden einer Blutbehandlungssitzung, wobei die Behandlungsvorrichtung (4) wenigstens einen extrakorporalen Blutkreislauf (1) mit einem Leitungsinneren; wenigstens eine Blutpumpe (11) zum Fördern von Blut innerhalb des Leitungsinneren des extrakorporalen Blutkreislaufs (1); und wenigstens eine Fördereinrichtung (17) zum Einbringen und/oder Fördern wenigstens einer Substituatflüssigkeit innerhalb des Leitungsinneren des extrakorporalen Blutkreislaufs (1) aufweist. Das Verfahren umfasst das Eintragen von Luft in das Leitungsinnere des extrakorporalen Blutkreislaufs (1) durch Betreiben der Blutpumpe (11) und das Einbringen von Substituatflüssigkeit in das Leitungsinnere des extrakorporalen Blutkreislaufs (1) durch Betreiben der Fördereinrichtung (17). Ferner wird eine geeignete Vorrichtung (4) angegeben ...

VORRICHTUNG ZUR AUSSERKOERPERLICHEN SAUERSTOFFANREICHERUNG DES BLUTES UND ZUR BLUTKREISLAUFUNTERSTUETZUNG.

EINRICHTUNG ZUR FILTRATION VON PLASMA AUS BLUT.

FLUID FLOW CHAMBER CASSETTE ASSEMBLY

Priming system

HEAT STERILISATION METHOD

FLOW/RETURN OF BLOOD CELLS TO A PATIENT/DONOR AFTER CENTRIFUGAL SEPARATION

Priming system

An exemplary priming assembly (100) comprises a container (10) of priming fluid, a syringe (1), flow control devices (4, 5, 12), a vent (6), a filter element (3), and a bypass assembly (20). In one embodiment, flow control devices (4, 5, 12) are adjusted so that priming fluid passes through the bypass assembly (20) and enters the syringe (1). Flow control device (12) is then adjusted so that gas is expelled through the vent (6). Flow control devices (4, 5, 12) are then adjusted so that priming fluid is directed into the filter (3), displacing gas as the priming fluid is returned to the container (10). ...

Modular home dialysis system

A method is described for priming a dialyzer placed in an extracorporeal circuit of a nemodialysis machine in situ. The method comprises the steps of substantially filling the extracorporeal circuit and the blood side of the dialyzer with fluid (such as dialysate, RO water, saline, etc.), and inducing pressure pulses in the fluid. The pressure pulses cause air bubbles from the blood side of the dialyzer to be sheared off the dialyzer membrane. The air bubbles are then conducted from the dialyzer and removed from the extracorporeal circuit. Backfiltering of fluid across the dialyzer from the dialysate circuit into the extracorporeal circuit is performed in synchrony with the pressure pulses to assist in the shearing off of air bubbles from the blood side of the dialyser membrane.

FLUID FLOW TRANSFER

HEMODIALYSESYSTEM

COMBINED EQUIPMENT TO THE HEAT EXCHANGE AND FOR THE EXHAUST OF A LIQUID.

PROCEDURE FOR THE ISOLATION AND RECUPERATION OF CELLS

DISINFECTION AND/OR CLEANING AGENT ACCESS FEATURE

HARDWARE SYSTEMS, METHODS AND APPARATUSES FOR AN AUTOMATED DIALYSIS MACHINE

PURGING SYSTEM FOR A BLOOD TUBING NETWORK

PERIPHERAL CARDIOPULMONARY BYPASS AND CORONARY REPERFUSION SYSTEM

RETROPERFUSION AND RETROINFUSION CONTROL APPARATUS, SYSTEM AND METHOD

Microfabricated artificial lung assist device, and methods of use and manufacture thereof

The invention provides systems and methods for exchanging gas in an oxygenator device, and methods for preparing and using such oxygenator devices. The systems and methods can be used to transfer oxygen to blood to assist lung function in a patient.

SYSTEM AND METHOD FOR VERIFYING ALIGNMENT OF DRUG PUMP AND FLUID SUPPLY

A patient care system is configured for infusing fluid to a patient. The system includes a plurality of fluid infusion pumps, each of which is connected to a respective fluid supply for pumping the contents of a fluid supply to a patient via fluid supply lines. The system includes a plurality of pressure sensors each associated with a fluid supply line downstream of the fluid infusion pumps for determining if a particular fluid is connected to a designated infusion pump.

Hemodialysis systems and methods

Absolute blood volume estimation using hemodilution

A machine for determining absolute blood volume using a hemodilution method is described herein.

HEMODIALYSIS SYSTEM

APPARATUS AND METHOD TO CHECK EXTRACORPOREAL CIRCUIT

An extracorporeal treatment apparatus including: a pump configured to pump a liquid through a passage in an extracorporeal circuit; a flow coupling connectable to an outlet end of the passage and having a known flow impedance; a liquid which: controls the pump to move liquid through the passage; collects data indicative of an actual pressure condition of the liquid being pumped through the passage, and identifies one of known ranges of pressure conditions which corresponds to the actual pressure condition; correlates the identified known range to at least one type of extracorporeal circuit, and determines if the one circuit type matches the type of extracorporeal circuit corresponding to the operational settings of the treatment apparatus or identifies the operational settings conforming to the one circuit type.

APPARATUS AND METHOD TO CHECK EXTRACORPEAL CIRCUIT

DEVICES, METHODS, AND SYSTEMS FOR PRIMING, SEPARATING, AND COLLECTING BLOOD COMPONENTS

A photopheresis system (200) is disclosed, and that may be configured to execute one or more protocols. These protocols include: 1) protocols (400; 430; 460) for purging air out of a centrifuge bowl (210) used by the photopheresis system (200); 2) protocols (500; 510 550) for assessing the installation/operation of one or more pressure domes (330) used by the photopheresis system (200); and 3) protocols (580; 600; 660; 700; 740) for collecting buffy coat from blood processed by the photopheresis system (200).

ABSOLUTE BLOOD VOLUME ESTIMATION USING HEMODILUTION

A machine for determining absolute blood volume using a hemodilution method is described herein.

METHOD AND SYSTEM FOR PROVIDING PRIMING AND RESTITUTION LIQUIDS FOR AN EXTRACORPOREAL BLOOD TREATMENT

A blood treatment system is primed with a replacement liquid that flows directly into the access line of the blood circuit. The replacement liquid may be replacement fluid or blood stored in the replacement bag or the pre-blood pump' (PBP) bag. These replacement liquids from the replacement and PBP bags are also used during blood treatment. These replacement liquids are blood or a replacement fluid and, particularly, have electrolyte levels the same as or similar to the electrolyte levels in the vascular blood of the patient.

METHOD AND APPARATUS FOR PRIMING AN EXTRACORPOREAL BLOOD CIRCUIT

A method and apparatus for priming an extracorporeal blood circuit, in wh ich the patient end of an arterial line (79) is connected to a first dischar ge port (61), and the patient end of a venous line (87) is connected to a se cond discharge port (62). The two discharge ports are connected to a used di alysate line which connects a dialyser (33) to a drain. The arterial and ven ous lines are filled with a priming fluid, while the air contained in the ar terial and venous lines is evacuated partly through the first discharge port and partly through the second discharge port. Two check valves (65, 66) pre vent flow from the used dialysate line towards the two discharge ports. The invention reduces the risk of errors on the part of an operator readying the priming configuration, as well as the risk of contamination of the extracor poreal circuit during the priming phase.

CONTROLLING AN APPARATUS FOR FLUID TRANSFER TO AND/OR FROM A SUBJECT

It is an object to facilitate the startup procedure in connection with a fluid transfer to/from a subject by means of a control system. The control system is an apparatus for extracorporeal blood treatment. The apparatus comprises an extracorporeal blood circuit and a connection system for connecting the extracorporeal blood circuit to the vascular system of a patient. The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The control system comprises an input for obtaining measurement data from at least one energy transfer sensor arranged to sense a transfer of energy between the patient and a connection system or between the patient and the extracorporeal blood circuit, and a signal processor configured to process the measurement data for detecting a connection of the extracorporeal blood circuit, the connection being detected by identifying a characteristic change in the measurement data.

APPARATUS AND METHOD TO CHECK EXTRACORPOREAL CIRCUIT

An extracorporeal treatment apparatus including: a pump configured to pump a liquid through a passage in an extracorporeal circuit; a flow coupling connectable to an outlet end of the passage and having a known flow impedance; a liquid which: controls the pump to move liquid through the passage; collects data indicative of an actual pressure condition of the liquid being pumped through the passage, and identifies one of known ranges of pressure conditions which corresponds to the actual pressure condition; correlates the identified known range to at least one type of extracorporeal circuit, and determines if the one circuit type matches the type of extracorporeal circuit corresponding to the operational settings of the treatment apparatus or identifies the operational settings conforming to the one circuit type.

SYSTEM AND METHOD OF PRIMING A SURGICAL CASSETTE

During small incision surgery, and particularly during ophthalmic surgery, small probes are inserted into the operative site to cut, remove, or otherwise manipulate tissue. During these surgical procedures, fluid is typically infused into the eye using an infusion system, and the infusion fluid and tissue are aspirated from the surgical site using an aspiration system. The infusion and aspiration systems must be primed prior to surgery. Gas can become trapped within the infusion system and the aspiration system, which can cause certain problems. In prior systems, the system and method of priming the surgical cassette did not remove the trapped gas from the systems. Therefore, a need continues to exist for an improved system and method of priming a surgical cassette.

VIAL SPIKING ASSEMBLIES AND RELATED METHODS

This disclosure relates to vial spiking assemblies and related methods. In certain aspects, the vial spiking assemblies include a vial adapter having a base, a spike extending from a central region of the base, and a sidewall extending from the base and surrounding the spike. The base and the sidewalls partially, define a cavity that is configured to receive at least a portion of the vial. The assemblies also include a spike cover that is removably attached to the spike and that includes a material configured to indicate when the material is contacted with liquid.

PRIMING SYSTEM

Processes and systems and methods for priming fluid processing apparatus and for treating a fluid are disclosed.

AUTOMATIC PRIMING OF BLOOD SETS

A blood processing system including a blood processing unit (12) and a tubular arterial set (10) and a tubular venous set (14) may be primed by passing priming solution in a first direction of flow through at least one of the sets, to cause the priming solution to enter an in-line chamber (64) carried by the one set in a flow direction that is retrograde to the normal direction of blood flow through the chamber (64). Preferably, the in-line filter chamber carries a filter (65). Simulteaneously, air is removed from the one set through a port. In another, preferably simultaneous step of the process, the priming solution is passed in a second flow direction, which is reverse the first flow direction, through the blood processing unit and connected sets while continuing to remove air from the system through the port, to complete priming of the system.

Systems and methods for multifunctional volumetric fluid control

피험자의 심장 혈관계의 특성의 모니터링

... 디바이스(25)가 피험자의 심장 혈관 특성을 모니터링하도록 구성된다. 디바이스(25)는 피험자의 심장 혈관계와 유체 연통하는 체외 유체 회로(20) 내의 압력파를 검출하도록 배열된 1차 압력파 센서(4a 내지 4c)로부터 측정 데이터를 얻는다. 디바이스는 측정 데이터에 기초하여 시간 의존성 모니터링 신호를 생성하여 모니터링 신호가 심장 펄스의 시퀀스를 포함하게 하고, 각각의 심장 펄스는 피험자 내의 심장 박동으로부터 기원하는 압력파를 표현하는 것이고, 모니터링 신호 내의 각각의 심장 펄스에 대한 박동 분류 데이터를 결정하고, 박동 분류 데이터에 적어도 부분적으로 기초하여, 심장 혈관 특성을 지시하는 파라미터값을 계산하도록 구성된 신호 프로세서(29)를 갖는다. 박동 분류 데이터는 정상 심장 박동으로부터 기원하는 심장 펄스와 이소성 심장 박동으로부터 기원하는 심장 펄스 사이를 구별할 수 있다. 심장 혈관 특성은 심장 혈관계의 동맥 상태, 심장 혈관계의 석회화의 정도, 체외 유체 회로(20)를 심장 혈관계에 접속하기 위해 사용된 혈관 액세스의 상태, 심박수 변동성, 심박수, 심박수 와류, 이소성 박동 계수 및 이소성 박동의 기원일 수 있다. 디바이스(25)는 투석 기계에 부착되거나 그 부분일 수 있다.

SEPARATION MEMBRANE FOR USE IN TREATMENT OF BLOOD, AND BLOOD TREATMENT DEVICE HAVING SAID MEMBRANE INTEGRATED THEREIN

... 본 발명의 목적은, 혈액 적합성이 높고, 보관 안정성을 가지며, 또한 방사선 멸균 처리를 실시하여도 막 성능이 열화하지 않는 혈액 처리용 분리막 및 그 막을 내장한 혈액 처리기를 제공하는 것이다. 본 발명의 목적은, 동시에, 혈액 처리막의 프라이밍 처리 시에 양호한 에어 누출성을 갖는 혈액 처리용 분리막 및 그 막을 내장한 혈액 처리기를 제공하는 것이다. 본 발명은, 폴리술폰계 고분자와, 친수성 고분자와, 20℃에 있어서의 물 100 g에의 용해도 0.5 g 이하의 측쇄에 수산기를 갖는 중합체로 이루어지고, 상기 중합체의 함량이 특정한 범위에 있는, 혈액 처리용 분리막 및 그 막을 내장한 혈액 처리기를 제공한다.

Method of removing blood from an extracorporeal blood circuit, treatment apparatus, and tube system

The present invention relates to a method of removing blood from an extracorporeal blood circuit following termination of a blood treatment session, wherein blood is concurrently removed both from an arterial conduit portion and from a venous conduit portion of the extracorporeal blood circuit. It further relates to a method for recognizing and/or eliminating air inclusions in or from an extracorporeal blood circuit and a treatment apparatus as well as a tube system.

Priming System and Method for Dialysis Systems

The application is directed to an extracorporeal blood processing system capable of using dialysate to prime the system. A plastic molded compact manifold supports molded blood and dialysate fluidic pathways along with relevant sensors, valves and pumps. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine. A two-way valve in the manifold is used to direct the dialysate flow through the blood circuit to prime the circuit for use in treatment. 1. A priming process for priming a manifold within a dialysis machine for use in a dialysis treatment , comprising the steps of:a. Inserting said manifold into the dialysis machine, wherein said manifold comprises a substrate defining a first circuit and a second circuit and a compressible valve structure in fluid communication with each of said first and second circuits, wherein said valve structure has a first state and a second state and wherein, when in said first state, fluid from the first circuit cannot enter into the second circuit and when in said second state, fluid from the first circuit can enter into the second circuit;b. Placing said valve in said second state by removing pressure from said compressible valve structure;c. Pumping fluid through said first and second circuits;d. Placing said valve in said first state by applying pressure to said compressible valve structure; ande. Removing fluid from said second circuit.2. The priming process of wherein the first circuit is a dialysate circuit and wherein the second circuit is a blood circuit.3. The priming process of wherein the fluid is dialysate and wherein claim 2 , in said second state claim 2 , the dialysate flows through the dialysate circuit and into the blood circuit.4. The priming process of wherein the dialysate is removed from the blood circuit upon completion of the priming process.5. The priming process of wherein the dialysate is pumped from a dialysate reservoir and not from a separate ...

Method for removing blood from an extracorporeal blood circuit for a treatment apparatus following termination of a blood treatment session, and apparatus for performing said method

A method for removing blood from an extracorporeal blood circuit of a treatment apparatus for the extracorporeal blood treatment of a patient following termination of a blood treatment session, wherein the treatment apparatus includes at least one extracorporeal blood circuithaving a conduit interior; at least one blood pump for conveying blood inside the conduit interior of the extracorporeal blood circuit; and at least one substitute pumpfor introducing or conveying at least one substituate fluid inside the conduit interior of the extracorporeal blood circuit. The method comprises feeding of air into the conduit interior of the extracorporeal blood circuitby operating the blood pump, and introducing substituate fluid into the conduit interior of the extracorporeal blood circuitby operating the substitute pump. In addition, a suitable apparatus is described.

Method for removing blood from an extracorporeal blood circuit as well as apparatuses

The present invention relates to a method for removing blood from an extracorporeal blood circuit and/or a functional device, each connectable or connected with a blood treatment apparatus for the purpose of blood treatment of a patient. The blood treatment apparatus of the method comprises or is connected with at least one extracorporeal blood circuit with a line having interior portions, the extracorporeal blood circuit comprising at least one arterial line section and at least one venous line section, wherein a first section of the arterial line section is configured to be connected with a second section of the venous line section, and further comprises at least one blood pump for conveying blood within the line interior portions. The method includes the step of operating the blood pump in a second conveying direction which is opposite to a first customary conveying direction. It further relates to corresponding apparatuses.

Cardiopulmonary bypass or cpb monitoring tool

A cardiopulmonary bypass or CPB monitoring tool includes: a preoperative information module; a preoperative calculation module able to estimate a body surface area, blood volume, and theoretical weight; a priming module able to determine priming constitution, volume and flow to achieve a hemodilution target; an operation risk module for calculating operation risk; a drug calculation module able to determine medication doses; a timer module with timers that can be activated during operation; a data collection module with an interface and drivers enabling data collection from a wide variety of extracorporeal pumps and oxygenators during operation; an events module with retroactive manipulation of the time of an event; a printing report generation module; a graphic user interface; and a configuration module.

Medical device receptacle filling method and apparatus

An apparatus and method for dispersing fluid from a fluid dispersal line is provided. The method comprises initiating operation of the medical apparatus, determining whether fluid has been dispersed from the medical apparatus via the fluid dispersal line since said initiating occurred, and assessing whether fluid is available in the fluid dispersal line. If fluid has not been dispersed from the medical apparatus since said initiating occurred and fluid is not available in the fluid dispersal line, the method includes distributing a commanded quantity of fluid plus an amount of fluid determined to fill the fluid dispersal line. Otherwise the method disperses only the commanded quantity of fluid.

Controlling an apparatus for fluid transfer to and/or from a subject

A control system ( 23 ) is arranged to control the operation of an apparatus ( 200 ) for extracorporeal blood treatment. The apparatus ( 200 ) comprises an extracorporeal blood circuit ( 20 ) and a connection system (C) for connecting the blood circuit ( 20 ) to the vascular system of a patient. The blood circuit ( 20 ) comprises a blood processing device ( 6 ), and at least one pumping device ( 3 ). The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The blood treatment mode involves operating the blood circuit ( 20 ) to pump blood from the vascular system via the connection system (C) through the blood processing device ( 6 ) and back to the vascular system via the connection system (C). The control system ( 23 ) is operable to obtain measurement data from at least one energy transfer sensor ( 40 ) arranged to sense a transfer of energy between the patient and the connection system (C) or between the patient and the blood circuit ( 20 ). The control system ( 23 ) is configured to, in the pre-treatment mode, process the measurement data for identification of a characteristic change indicating a connection of the blood circuit ( 20 ) to the vascular system of the patient, and, upon such identification, take dedicated action. The action may involve activating at least part of a patient protection system and/or enabling entry into the blood treatment mode. The control system may be included in an apparatus ( 200 ) for blood treatment, such as a dialysis machine.

Method and system for detecting or verifying a blood circuit connected to an extracorporeal blood treatment console

A method to determine a type of blood circuit attached to an extracorporeal blood treatment console including: pumping a liquid through a blood passage of the blood circuit, sensing a first pressure in: the blood passage while the passage is closed and pumping stopped, pumping an additional amount of the liquid into the blood passage while the blood passage is and remains closed and thereafter sensing a second pressure, and determine a dimensional characteristic of a fluid passage in the blood passage based on the additional amount of the liquid and the second pressure.

Devices, systems, and methods for cleaning, disinfecting, rinsing, and priming blood separation devices and associated fluid lines

Systems and methods for providing for the automatic instrument-based rapid reprocessing of an intact extracorporeal circuit for use in hemodialysis. The system includes a manifold with connectors for engaging a dialyzer as well as venous and arterial blood lines. The manifold is adapted to be moved from a dialysis machine to a reuse instrument without removing the dialyzer and associated blood lines. The system allows for reprocessing of the extracorporeal circuit wherein prior to the next treatment, there is no residual chemical disinfectant requiring testing, the extracorporeal circuit is pre-primed, the levels in the bubble traps are set, and all of the required quality assurance tests are performed and recorded.

Blood perfusion system

An extracorporeal blood perfusion system includes a disposable assembly and a control unit having a control interface region. The interface region includes pump assemblies for selective pumping of venous blood, arterial blood, cardioplegia solution, suctioned blood and blood removed from the left ventricle. Valve assemblies control the flow of fluids through the assembly and to/from the patient and sensors monitor various fluid parameters including temperature and pressure within the various fluid circuits. The user interface is a functional screen interface for effecting the operation of the control unit and valve assemblies. The screen interface may be a touch screen having objects that corresponds to the component interface region. The display may be selectively controlled to provide graphic depictions of disposable assembly components with corresponding narrative instructions.

Priming anticoagulant line for blood extraction

Methods and devices are described for reducing anticoagulant dilution of collected blood components during blood collection.

Modular Blood Treatment Systems, Units, and Methods

A portable adapter is provided that can include a closure system configured to control the flow of blood and/or dialysate between the adapter and a blood treatment apparatus. Modular systems are also provided that include the portable adapter engaged with various units such as a portable blood processing module, a non-portable base module, and/or a remote module. Methods of conducting blood treatments such as blood circulation, hemodialysis, and hemofiltration, hemodiafiltration, using the modular systems are also provided. The systems, units, and methods enable the engagement and disengagement of the adapter from the various units to conduct, interrupt, and resume blood treatments without disconnecting the adapter from the vasculature of a patient. Modular systems including interchangeable portable and base modules configured for various blood treatments are also provided that can be engaged and disengaged with each other without disconnecting the portable module from the vasculature of a patient. 1. A modular system comprising:a first base module comprising a dock and configured to dock a portable extracorporeal blood circuit module, the first base module comprising a base module housing, a primary dialysate circuit comprising a primary dialysate pump, a primary dialysate line, and a first inter-module connector; anda first portable module configured to dock the first base module in a docked configuration and configured to operate independently of the first base module in an undocked configuration, the first portable module comprising a first portable module housing, a blood pump mounted in or on the first portable module housing, a first extracorporeal blood circuit tubing set, and a second inter-module connector complementary to the first inter-module connector and configured to connect to the first inter-module connector in the docked configuration, wherein the blood pump is configured to releasably engage the extracorporeal blood circuit tubing set.2. The ...

Blood purification apparatus

A blood purification apparatus including a line section through which working dialysate to be introduced into a blood purifier or drain liquid discharged from the blood purifier is caused to flow; a delivery unit that delivers liquid in the line section; an introduction port connected to a supply route through which undiluted dialysate or the working dialysate is supplied, the introduction port allowing the undiluted dialysate or the working dialysate in the supply route to be introduced into the apparatus; an introduction route connected to the introduction port and through which the undiluted dialysate or the working dialysate introduced from the introduction port flows into the line section; a valve unit provided to the introduction route and being capable of opening or closing the introduction route by being opened or closed; and a control unit that controls an operation of opening or closing the valve unit. The control unit is capable of executing a flushing step in which when a cleaning solution or a disinfecting solution is caused to flow through the supply route, the valve unit is opened to allow the cleaning solution or the disinfecting solution flowing in the supply route to flow into the introduction route and through the line section to be discharged to an outside of the apparatus.

DIALYSIS SYSTEM HAVING INDUCTIVE HEATING

A dialysis fluid system includes a dialysis fluid inlet; a dialysis fluid outlet; a pump positioned and arranged to pump dialysis fluid through the dialysis fluid inlet and the dialysis fluid outlet; and an inductive heater located between the dialysis fluid inlet and the dialysis fluid outlet, the inductive heater including a fluid flowpath positioned and arranged to receive non-heated dialysis fluid from the dialysis fluid inlet and to output heated dialysis fluid to the a dialysis fluid outlet, a conductive heater element located within the fluid flowpath so as to be or act as a secondary coil of a transformer, and a primary coil of the transformer located outside of the fluid flowpath and positioned so as to magnetically induce a current into the conductive heater element, causing the conductive heater element and surrounding fluid to heat. 1. A dialysis fluid system comprising:a dialysis fluid inlet;a dialysis fluid outlet;a pump positioned and arranged to pump dialysis fluid through the dialysis fluid inlet and the dialysis fluid outlet; and a fluid flowpath positioned and arranged to receive non-heated dialysis fluid from the dialysis fluid inlet and to output heated dialysis fluid to the dialysis fluid outlet,', 'a conductive heater element located within the fluid flowpath so as to be or act as a secondary coil of a transformer, and', 'a primary coil of the transformer located outside of the fluid flowpath and positioned so as to magnetically induce a current into the conductive heater element, causing the conductive heater element and surrounding dialysis fluid to heat., 'an inductive heater located between the dialysis fluid inlet and the dialysis fluid outlet, the inductive heater including'}2. The dialysis fluid system of claim 1 , wherein the fluid flowpath and the conductive heater element are located within a heater housing in fluid communication with the dialysis fluid inlet and the dialysis fluid outlet.3. The dialysis fluid system of claim 2 , ...

Improved dialyzer holder and improved airless bloodline priming method

The present invention relates to a dialyzer holder to attach a dialyzer to a dialysis machine. During priming of a bloodline prior to a dialysis treatment, the dialyzer holder grips a dialyzer in approximately the center of the dialyzer, but allows movements of the dialyzer in an arc motion using two axes of rotation. The holder enables the dialyzer to move to a position where air can be primed from the dialyzer and, because the dialyzer can move toward the dialysis machine, this motion eliminates stress on the tubing connected to the bottom and top of the dialyzer and reduces the length of bloodline tubing necessary to accommodate dialyzer movement. The dialyzer holder incorporates an attachment point for a venous chamber for use during the priming procedure, enabling the venous chamber to move with the dialyzer, further reducing the tubing between the dialyzer and the venous chamber.

METHOD FOR PRODUCING CELL CONCENTRATE, AND CELL SUSPENSION TREATMENT SYSTEM

In a method for producing a cell concentrate using a cell suspension treatment system including a storage container of a cell suspension, which has a solution inlet port, a circulation outlet port, and a circulation inlet port, a cell suspension treatment device for concentrating the cell suspension by separating liquid from the cell suspension by filtration, the device including a container having a cell suspension introduction port, a cell suspension lead-out port, and a filtrate outlet, which is filled with a hollow fiber separation membrane, a circulation circuit for concentrating the cell suspension while circulating the cell suspension between the storage container and the cell suspension treatment device, a collection container of a cell concentrate obtained by concentration, a collection path for feeding the cell concentrate to the collection container, an injection path for injecting a solution into the solution inlet port of the storage container, and a detecting unit. 1. A cell suspension treatment system comprising:a storage container of a cell suspension, which has a solution inlet port, a circulation outlet port, and a circulation inlet port;a cell suspension treatment device for concentrating the cell suspension by separating liquid from the cell suspension by filtration, the device including a container having a cell suspension introduction port, a cell suspension lead-out port, and a filtrate outlet, which is filled with a hollow fiber separation membrane,a circulation circuit for concentrating the cell suspension while circulating the cell suspension between the storage container and the cell suspension treatment device, the circuit being constituted by an introduction communication tube communicating the circulation inlet port of the storage container and the cell suspension introduction port of the cell suspension treatment device and a lead-out communication tube communicating the cell suspension lead-out port of the cell suspension treatment ...

Dialysis system including automatic priming

A hemodialysis system comprising: a source of priming fluid; an extracorporeal circuit including an arterial line, a venous line, and a drip chamber; a level sensor operable with the drip chamber; a reversible blood pump operable with the extracorporeal circuit; a connection between the arterial and the venous line; and a priming sequence in which priming fluid from the source is pumped in a reverse pump direction through the extracorporeal circuit and reversibly in a normal pump direction through the extracorporeal circuit, wherein an output from the level sensor is used to determine when to stop pumping in at least one of the directions.

Spike with non-return valve function and filling device of a liquid system with spike

Disclosed is an anti-contamination device for preventing contamination of a fluid stored in a fluid container with a spike and a manually operable fluid blocking mechanism arranged directly downstream of the spike. A non-return valve is arranged between the spike and the fluid blocking mechanism, and that valve is adapted to allow only a flow from the spike in the direction of the manually operable fluid blocking mechanism.

Valve Actuation Systems and Related Methods

In one aspect, a valve actuation system includes a drive unit including an actuator configured to engage and move multiple valves disposed within a fluid cassette to selectively open and close each valve of the multiple valves and a positioning frame disposed adjacent the fluid cassette and along which the drive unit can be moved in three dimensions to align the actuator with a selected valve of the multiple valves. 1. A valve actuation system , comprising:a drive unit comprising an actuator configured to engage and move a plurality of valves disposed within a fluid cassette to selectively open and close each valve of the plurality of valves; anda positioning frame disposed adjacent the fluid cassette and along which the drive unit can be moved in three dimensions to align the actuator with a selected valve of the plurality of valves.2. The valve actuation system of claim 1 , wherein the drive unit is carried by the positioning frame.3. The valve actuation system of claim 1 , wherein the actuator is formed to mate with a complementary feature of each of the plurality of valves.4. The valve actuation system of claim 1 , wherein the actuator is configured to be controlled to apply a force to each valve of the plurality of valves to rotate each valve of the plurality of valves.5. The valve actuation system of claim 4 , wherein the actuator is configured to open and close each valve of the plurality of valves.6. The valve actuation system of claim 4 , wherein the force is a rotational force.7. The valve actuation system of claim 1 , wherein the positioning frame further comprises a first linear rail claim 1 , a second linear rail claim 1 , and a third linear rail along which the drive unit can be moved linearly to align the actuator with the selected valve.8. The valve actuation system of claim 7 , wherein the drive unit is configured to traverse the first claim 7 , second claim 7 , and third linear rails in a total time of up to about 0.5 seconds to about 2.0 seconds.9 ...

Blood Purification Apparatus

A blood purification apparatus employing a single-needle double-pump method and being capable of automatically discharging a priming solution that has undergone substitution from a blood circuit during blood removal. A blood purification apparatus includes a blood circuit to which an only puncture needle is connectable, a dialyzer that purifies blood flowing in the blood circuit, a first blood pump, a second blood pump, and a control device that allows the blood of a patient to be extracorporeally circulated through the blood circuit by causing the first blood pump and the second blood pump to alternately undergo normal rotation. During blood removal, the control device operates to substitute a priming solution in the blood circuit with the blood of the patient and to discharge the priming solution having undergone the substitution from the blood circuit by causing the first blood pump to undergo normal rotation and the second blood pump to undergo reverse rotation. 1. A blood purification apparatus that performs blood purification treatment while extracorporeally circulating blood of a patient by using an only puncture needle , the apparatus comprising:a blood circuit including an arterial blood circuit and a venous blood circuit to respective distal ends of which the only puncture needle is connectable, the blood circuit allowing the blood of the patient to be extracorporeally circulated from the distal end of the arterial blood circuit to the distal end of the venous blood circuit;a blood purification device provided between the arterial blood circuit and the venous blood circuit and that purifies the blood flowing in the blood circuit;a first blood pump that is a peristaltic pump provided to the arterial blood circuit and is capable of introducing the blood of the patient into the blood circuit through the puncture needle when activated to undergo normal rotation;a second blood pump that is a peristaltic pump provided to the venous blood circuit and is capable ...

BLOOD TREATMENT AIR PURGING SYSTEMS

Dialysis systems that remove air from a blood circuit are disclosed herein. In an embodiment, a dialysis system includes a dialysis fluid circuit, a blood circuit including an arterial line, a venous line, and an enclosure in fluid communication with the venous line, the enclosure configured to release air through a hydrophobic vent for priming the blood circuit, a blood pump configured to pump fluid through at least the arterial line, a first valve operable with the arterial line and a second valve operable with the venous line, and a pumping and valving algorithm operated after priming to remove air from the blood circuit to control the first and second valves and the blood pump to replace priming fluid with blood from a patient. 1. A dialysis system comprising:a dialysis fluid circuit; an arterial line,', 'a venous line, and', 'an enclosure in fluid communication with the venous line, the enclosure configured to release air through a hydrophobic vent for priming the blood circuit;, 'a blood circuit including'}a blood pump configured to pump fluid through at least the arterial line;a first valve operable with the arterial line and a second valve operable with the venous line; anda pumping and valving algorithm operated after priming to remove air from the blood circuit to control the first and second valves and the blood pump to replace priming fluid with blood from a patient.2. The dialysis system of claim 1 , wherein the enclosure includes an air trap.3. The dialysis system of claim 1 , wherein the hydrophobic vent communicates with the enclosure via a vent line.4. The dialysis system of claim 1 , wherein the priming fluid includes saline claim 1 , heparin or dialysis fluid.5. The dialysis system of claim 1 , wherein the pumping and valving algorithm controls the first and second valves and the blood pump so that the blood from the patient replaces the priming fluid while both the arterial line and the venous line are connected to the patient.6. The dialysis ...

CARDIOPULMONARY APPARATUS AND METHODS FOR PRESERVING LIFE, PRESERVING ORGAN VIABILITY AND/OR FOR USE DURING PCI AND CABG

Apparatus and methods for providing extracorporeal blood circulation and oxygenation control include multi-stage deairing of blood to provide automated cardiopulmonary replacement to sustain patient life during a medical procedure such as; cardiopulmonary bypass graft surgery, keyhole cardiopulmonary bypass graft surgery, percutaneous angioplasty, percutaneous stent placement, and percutaneous atherectomy, repairing or replacing the heart valve and/or for perfusing an organ or the body of an organ donor to preserve viability of organ(s) for transplantation. 1a) priming a heart-lung machine with a priming liquid in a priming mode;b) switching the heart lung machine from the priming mode to an operational mode;c) connecting a venous blood inlet on the heart lung machine to a vein in the. A method for providing extracorporeal circulation to a patient or organ donor comprising the steps of:d) operating the heart-lung machine in said operational mode to take venous blood from the patient, oxygenate the venous blood, and return oxygenated blood to the patient or organ donor; andwherein:said heart-lung machine comprises a centrifugal pump head having a central inletand a tangential outlet; andsaid central inlet to the centrifugal pump head is oriented vertically upward duringpriming step a) and horizontally during operating step d.patient or organ donor and connecting an arterial blood outlet from the heart lung machine to an artery in the patient or organ donor to form a closed extracorporeal blood circulation in fluid contact with the patient or organ donor's circulatory system; This application is a continuation in part of:Also incorporated by reference in this application are the entire disclosures of each of the following: U.S. patent application Ser. No. 11/284,515 filed Nov. 22, 2005 entitled Apparatus For Making Extracorporeal Blood Circulation Available; European Patent Application No. EP 04 027 855.8 filed on Nov. 24, 2004 entitled Vorrichtung zur Bereitstellung ...

Rotary Valves for Dialysis Systems

In one aspect, a dialysis fluid cassette includes an inlet fluid line, multiple outlet fluid lines, and a valve including an actuation feature by which the valve can be rotated to fluidly communicate the inlet fluid line with a selected fluid line of the multiple outlet fluid lines. 1. A dialysis fluid cassette , comprising:an inlet fluid line;a plurality of outlet fluid lines; anda valve comprising an actuation feature by which the valve can be rotated to fluidly communicate the inlet fluid line with a selected fluid line of the plurality of outlet fluid lines.2. The dialysis fluid cassette of claim 1 , wherein the actuation feature comprises a surface profile that is formed to be engaged by an actuator for rotating the valve.3. The dialysis fluid cassette of claim 1 , wherein the actuation feature has a polygonal shape.4. The dialysis fluid cassette of claim 1 , wherein the actuation feature has a symmetric shape.5. The dialysis fluid cassette of claim 1 , wherein the actuation feature has an asymmetric shape.6. The dialysis fluid cassette of claim 1 , wherein the actuation feature comprises a recessed profile.7. The dialysis fluid cassette of claim 1 , wherein the actuation feature comprises a protrusion that extends from a main body of the valve.8. The dialysis fluid cassette of claim 1 , wherein the valve further comprises an indicator having an orientation that corresponds to the selected fluid line.9. The dialysis fluid cassette of claim 1 , wherein the valve further comprises:a valve body defining an internal fluid pathway that can fluidly communicate the inlet fluid line with the selected fluid line; anda spring that is configured to move the valve body to enable or disable an operation of the valve.10. The dialysis fluid cassette of claim 9 , wherein the valve body is movable to:a first position at which the internal fluid pathway is aligned with the inlet fluid line and the plurality of outlet fluid lines to enable the operation of the valve, anda second ...

Systems and methods for automated recovery of white blood cells after producing a leuko-reduced blood product

The present disclosure relates to systems and methods for the separation of blood into blood products and, more particularly, to systems and methods that permit automated recovery of white blood cells after producing a leukocyte-reduced blood product.

CONTROLLING AN APPARATUS FOR FLUID TRANSFER TO AND/OR FROM A SUBJECT

A control system () is arranged to control the operation of an apparatus () for extracorporeal blood treatment. The apparatus () comprises an extracorporeal blood circuit () and a connection system (C) for connecting the blood circuit () to the vascular system of a patient. The blood circuit () comprises a blood processing device (), and at least one pumping device (). The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The blood treatment mode involves operating the blood circuit () to pump blood from the vascular system via the connection system (C) through the blood processing device () and back to the vascular system via the connection system (C). The control system () is operable to obtain measurement data from at least one energy transfer sensor () arranged to sense a transfer of energy between the patient and the connection system (C) or between the patient and the blood circuit (). The control system () is configured to, in the pre-treatment mode, process the measurement data for identification of a characteristic change indicating a connection of the blood circuit () to the vascular system of the patient, and, upon such identification, take dedicated action. The action may involve activating at least part of a patient protection system and/or enabling entry into the blood treatment mode. The control system may be included in an apparatus () for blood treatment, such as a dialysis machine. 131-. (canceled)32. An apparatus for extracorporeal blood treatment , comprising:an extracorporeal blood circuit and a connection system configured to connect the extracorporeal blood circuit to the vascular system of a patient, the extracorporeal blood circuit comprising a blood processing device;at least one pressure sensor configured to sense pressure pulses from a physiological pulse generator in the patient;at least one pumping device; and a sensor signal input device to obtain measurement data from the at least one ...

Methods and apparatus for kidney dialysis and extracorporeal detoxification

The present disclosure relates to a dialysis apparatus comprising a membrane having at least one protein from the lipocalin family bound thereon. The disclosure further relates to methods of removing non-polar, hydrophobic and/or protein bound uremic toxins from a target subject utilizing the dialysis apparatus described herein as well as methods of extracorporeal detoxification.

HEMODIALYSIS SYSTEM

A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly. 182.-. (canceled)83. A drain cassette that is connectable to and disconnectable from a front panel of a dialysis unit by a user of the dialysis unit , comprising:a venous connection port for connection to, and fluid communication with, a venous blood line connector that terminates a venous line of a blood circuit assembly;an arterial connection port for connection to, and fluid communication with, an arterial blood line connector that terminates an arterial line of the blood circuit assembly;a fluid channel fluidly connecting the venous connection port and the arterial connection port;a drain outlet port in fluid communication with the fluid channel and arranged to removably couple with a drain connector on the front panel of the dialysis unit; anda valve arranged to control flow in the fluid channel,wherein the valve is arranged to control in the fluid channel to either controllably open and close fluid communication in the fluid channel between the drain outlet port and the venous connection port, or to controllably open and close fluid communication in the fluid channel between the drain ...

Dialysis systems including therapy prescription entries

A dialysis system includes a dialysis machine configured to control fluid loss or ultrafiltration (“UF”) volume over a treatment; a graphical user interface (“GUI”) that allows selection of a prescription entry for the treatment; and a processor operating with the GUI, the processor programmed to (i) receive a plurality of prescription entries via a local or wide area mode of data communication, each prescription entry including at least one prescribed parameter for operating the dialysis machine to control the fluid loss or UF volume, and (ii) enable an operator to choose between the prescription entries provided at the GUI, and select one of the prescription entries for the treatment.

Methods and apparatus for kidney dialysis and extracorporeal detoxification

The present disclosure relates to a dialysis apparatus comprising a membrane having at least one protein from the lipocalin family bound thereon. The disclosure further relates to methods of removing non-polar, hydrophobic and/or protein bound uremic toxins from a target subject utilizing the dialysis apparatus described herein as well as methods of extracorporeal detoxification. 131.-. (canceled)32. A method of dialysis to remove a nonpolar , hydrophobic , and/or protein-bound uremic toxin from the blood or plasma of a subject , comprising subjecting the blood or plasma to an apparatus comprising a body having an inlet and an outlet and defining an interior , the interior including at least one membrane having at least one protein from the lipocalin family bound thereon , the at least one protein being one that binds to the uremic toxin , the apparatus being arranged so that the blood or plasma entering the apparatus contacts the at least one protein from the lipocalin family bound to the at least one membrane in the interior of the apparatus.33. The method of claim 32 , where the at least one protein from the lipocalin family is selected from the group consisting of alpha-1-microglobulin (protein HC) claim 32 , major urinary proteins claim 32 , alpha-1-acid glycoprotein (orosomucoid) claim 32 , aphrodisin claim 32 , apolipoprotein D claim 32 , beta-lactoglobulin claim 32 , complement component C8 gamma chain claim 32 , crustacyanin claim 32 , epididymal-retinoic acid binding protein (E-RABP) claim 32 , insectacyanin claim 32 , odorant binding protein (OBP) claim 32 , human pregnancy-associated endometrial alpha-2 globulin (PAEP) claim 32 , probasin (PB) claim 32 , a prostatic protein claim 32 , prostaglandin D synthase claim 32 , purpurin claim 32 , Von Ebner's gland protein (VEGP) claim 32 , and lizard epididymal secretory protein IV (LESP IV).34. The method of claim 32 , where the at least one protein from the lipocalin family is selected from the group ...

Hemodialysis system including a disposable cassette

A dialysis system includes a dialyzer, a sorbent cartridge configured to clean used dialysate from the dialyzer, a dialysate pump actuator configured to pump dialysate to the dialyzer, and a conductivity sensor located adjacent to a temperature sensor. The dialysis system also includes a disposable cassette configured to carry dialysate pumped by the dialysate pump actuator. The disposable cassette includes a combined conductivity and temperature sensor fluid chamber separate from the conductivity sensor and the temperature sensor and located so as to operate with the conductivity sensor and the temperature sensor, respectively, when mounted for operation.

METHOD FOR DETERMINING AT LEAST ONE PARAMETER OF AN EXTRACORPOREAL BLOOD CIRCUIT AS WELL AS APPARATUSES

A method for determining at least one parameter of an extracorporeal blood circuit includes the steps of filling an extracorporeal blood circuit, e.g., encompassing a medical functional device, a treatment device and/or a blood tube set, by introducing a fluid, and detecting a volume of the introduced fluid which is required for filling the extracorporeal blood circuit by a detection device. A control device, a treatment apparatus, a computer readable storage medium, a computer program product as well as a computer program are also described. 1. A method for determining at least one parameter of an extracorporeal blood circuit or a component thereof , comprising:filling the extracorporeal blood circuit by introducing a fluid; andone of detecting, determining and calculating a size of a volume of the introduced fluid which is required for filling at least one of the extracorporeal blood circuit and a predetermined section thereof.2. The method according to claim 1 , wherein the filling serves as a preparation of the extracorporeal blood circuit.3. The method according to claim 1 , further comprising:processing a value of the detected fluid volume for maintaining the at least one parameter.4. The method according to claim 1 , wherein the volume of the fluid is a cumulative volume.5. The method according to claim 1 , further comprising:conveying the fluid through the at least one of the extracorporeal blood circuit and the predetermined section thereof by a blood pump having at least one of a constant and a predetermined flow;determining a point in time when the fluid appears at a first sensor of the extracorporeal blood circuit as a first point in time;determining a point in time when the fluid appears at a second sensor of the extracorporeal blood circuit as a second point in time;determining a time difference between the first point in time and the second point in time;wherein the one of detecting, determining and calculating of the size of the volume of the ...

BLOOD PURIFICATION APPARATUS

A blood purification apparatus is provided that allows setting work at the time of blood purification treatment or preparation for the treatment to be easily and smoothly performed. The blood purification apparatus includes: a circuit for blood purification having an arterial blood circuit and a venous blood circuit that constitute a blood circuit; a dialyzer for purifying the blood extracorporeally circulated by the blood circuit; and a dialysis device main body, wherein the blood purification apparatus includes an identification means that allows specific information to be identified, the specific information including an operating condition of the circuit for blood purification or the dialyzer at the time of blood purification treatment or preparation for the treatment, a reading means by which the specific information of the identification means is readable, and a control unit that performs blood purification treatment or preparation for the treatment based on the operating condition in the specific information read by the reading means. 1. A blood purification apparatus comprising:a circuit for blood purification having an arterial blood circuit and a venous blood circuit that constitute a blood circuit for extracorporeally circulating at least blood of a patient;a blood purifier for purifying the blood extracorporeally circulated by the blood circuit;a device main body provided with various treatment means for performing blood purification treatment in the blood circuit and the blood purifier,wherein the blood purification apparatus includes an identification means that allows specific information to be identified, the specific information including an operating condition of the circuit for blood purification or the blood purifier at the time of blood purification treatment or preparation for the treatment,a reading means by which the specific information of the identification means is readable, anda control unit that performs blood purification treatment or ...

EXTRACORPOREAL OXYGENATOR WITH INTEGRATED AIR REMOVAL SYSTEM

Extracorporeal blood flow circuit devices can be used during medical procedures such as on-pump open-heart surgery. For example, extracorporeal heat exchange and oxygenation devices can be used to facilitate surgical procedures such as coronary artery bypass grafting. In some embodiments, such an oxygenation device can include an integrated air removal structure. In particular embodiments, the air removal structure can comprise one or more porous hollow fibers. 1. A blood oxygenator apparatus , comprising:a blood inlet and a blood outlet, a blood flow path extending from the blood inlet to the blood outlet;a gas exchange portion disposed along the blood flow path;a heat exchange portion disposed along the blood flow path prior to the gas exchange portion; andone or more porous hollow fibers disposed along the blood flow path prior to the heat exchange portion.2. The blood oxygenator apparatus of claim 1 , wherein an inside of the one or more porous hollow fibers is communicative to an ambient space within or around the blood oxygenator apparatus.3. The blood oxygenator apparatus of claim 1 , wherein an inside of the one or more porous hollow fibers is communicative to a vacuum source.4. The blood oxygenator apparatus of claim 1 , further comprising a flow distribution element disposed along the blood flow path prior to the one or more porous hollow fibers.5. The blood oxygenator apparatus of claim 4 , wherein the one or more porous hollow fibers are wound around the flow distribution element.6. The blood oxygenator apparatus of claim 5 , wherein the one or more porous hollow fibers are wound around the flow distribution element in a crisscrossing helical pattern.7. The blood oxygenator apparatus of claim 4 , wherein the one or more porous hollow fibers are disposed around the flow distribution element in a non-crossing pattern.8. The blood oxygenator apparatus of claim 1 , wherein pores of the one or more porous hollow fibers allow air to enter an inside of the one ...

HEMODIALYSIS SYSTEMS AND METHODS

The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. In some cases, a gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer that, when activated, is able to urge dialysate to pass through the dialyzer and urge blood in the blood flow path back to the patient. Such a system may be useful, for example, in certain emergency situations (e.g., a power failure) where it is desirable to return as much blood to the patient as possible. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air. In some cases, the control fluid may be delivered to the fluid handling devices using an external pump or other device, which may be detachable in certain instances. In one embodiment, one or more of the fluid handling devices may be generally rigid (e.g., having a spheroid shape), optionally with a diaphragm contained within the device, dividing it into first and second ...

HEMODIALYSIS SYSTEMS AND METHODS

Hemodialysis systems are described. A hemodialysis system may include a dialysate flow path through which dialysate is passed from a dialysate reservoir, which includes a valved vent to atmosphere, to an ultrafilter. The dialysate flow path includes a pneumatically actuated diaphragm-based dialysate pump for pumping fluid from the dialysate reservoir to the ultrafilter. The hemodialysis system may include a controller for controlling pneumatic actuation pressure delivered to the dialysate pump and at least one valve connecting the dialysate reservoir vent to the atmosphere. The hemodialysis system may be configured to actuate the dialysate pump and the at least one valve to introduce air into the dialysate flow path and expel liquid from the dialysate flow path to a drain. 1142.-. (canceled)143. A hemodialysis system comprising:a dialysate flow path through which dialysate is passed from a dialysate reservoir to an ultrafilter;the dialysate flow path comprising a pneumatically actuated diaphragm-based dialysate pump for pumping fluid from the dialysate reservoir to the ultrafilter;the dialysate reservoir including a valved vent to atmosphere; anda controller for controlling pneumatic actuation pressure delivered to the dialysate pump and at least one valve connecting the dialysate reservoir vent to the atmosphere;wherein the hemodialysis system is configured to actuate the dialysate pump and the at least one valve to introduce air into the dialysate flow path and expel liquid from the dialysate flow path to a drain.144. The hemodialysis system of claim 143 , wherein the dialysate pump comprises a pneumatic actuation chamber separated from a pumping chamber by a flexible diaphragm claim 143 , the pneumatic actuation chamber in communication with a pressure sensor claim 143 , and wherein pressure data from the pressure sensor is monitored by the controller while air is pumped by the dialysate pump from the dialysate reservoir to the ultrafilter.145. The hemodialysis ...

FLUID CIRCUIT FOR DELIVERY OF RENAL REPLACEMENT THERAPIES

A portable dialysis cabinet for use in dialysis. The portable dialysis cabinet can have a size and weight that facilitates easy movement of the cabinet from one location to another with relative ease. The portable dialysis cabinet can have additional features necessary to facilitate portability, such as wheels and a handle. In general, the portable dialysis cabinet can contain all the necessary components for performing a dialysis session. 1. A portable dialysis cabinet , comprising:a dialysis system;at least two wheels disposed on a bottom surface of the dialysis cabinet;a first pair of opposing doors hingeably disposed on the dialysis cabinet creating when said doors are closed a first and second interior portions of the dialysis cabinet, the first pair of opposing doors having a first door connected to the dialysis cabinet by a first hinge on a front left side of the dialysis cabinet and a second door connected to the dialysis cabinet by a second hinge on a front right side of the dialysis cabinet, wherein the first door opens by swinging about a first vertical axis defined by a the first hinge on the left side of the dialysis cabinet and the second door opens by swinging about a second vertical axis defined by the second hinge on front right side of the dialysis cabinet; wherein the first door and second door are in contact when the first door and second door are closed; wherein the first and second interior portions are occupied by one or more interior components when closed; andat least one mounting surface for mounting a sorbent cartridge on a base of at least one of the first and second doors.2. The portable dialysis cabinet of claim 1 , further comprising at least a second mounting surface for mounting a reservoir on at least one of the first and second doors.3. The portable dialysis cabinet of claim 1 , wherein the first pair of opposing doors in an opened configuration provide access to one or more fluid connection ports located on a main body of the base ...

Blood Purification Apparatus

A blood purification apparatus is provided in which parameters related to ultrafiltration can be changed assuredly and smoothly at the restart of blood purification treatment suspended with the release of the patient from a blood circuit during the blood purification treatment. A blood purification apparatus in which the blood purification treatment that is suspended with a release of the patient from a blood circuit during the blood purification treatment is restartable includes a calculating device capable of calculating a variable amount related to a patients body weight that changes with the suspension and restart of the blood purification treatment; and a changing device capable of changing, in accordance with the variable amount calculated by the calculating device, a parameter related to ultrafiltration that is set by a setting device. 1: A blood purification apparatus comprising:a blood circuit through which blood of a patient is allowed to extracorporeally circulate;a blood purifier for giving blood purification treatment by purifying the blood of the patient that extracorporeally circulates through the blood circuit;an ultrafiltration device capable of performing ultrafiltration for removing water from liquid in the blood circuit;an infusion device capable of performing fluid infusion or blood return by introducing liquid into the blood circuit;a setting device capable of setting a parameter related to ultrafiltration performed by the ultrafiltration device; anda control device that controls the ultrafiltration device in accordance with the parameter that is set by the setting device,wherein the blood purification treatment that is suspended with a release of the patient from the blood circuit during the blood purification treatment is restartable,wherein the blood purification apparatus further includesa calculating device capable of calculating a variable amount related to the patient's body weight that changes with the suspension and restart of the ...

TECHNIQUES FOR DETERMINING PATIENT BLOOD CHARACTERISTCS DURING A DIALYSIS PROCESS

Techniques and apparatus for de-priming processes are described. For example, in one embodiment, an apparatus may include at least one processor and a memory coupled to the at least one processor, the memory may include instructions that, when executed by the processor, may cause the at least one processor to determine a priming volume of a primer fluid infused into a priming system associated with the patient during a priming phase of the dialysis treatment, cause an ultrafiltration rate of an ultrafiltration pump of the dialysis machine in fluid communication with the patient to be changed from a treatment ultrafiltration rate to a de-priming ultrafiltration rate to remove the priming volume over a de-priming time period, and cause, after the de-priming time period, the ultrafiltration rate of the ultrafiltration pump to be changed back the treatment ultrafiltration rate. Other embodiments are described. 1. An apparatus , comprising:at least one memory; and determine a priming volume of a primer fluid infused into a priming system associated with the patient during a priming phase of the dialysis treatment,', 'cause an ultrafiltration rate of an ultrafiltration pump of the dialysis machine to be changed from a treatment ultrafiltration rate to a de-priming ultrafiltration rate to remove the priming volume over a de-priming time period, and', 'cause, after the de-priming time period, the ultrafiltration rate of the ultrafiltration pump to be changed back to the treatment ultrafiltration rate., 'logic coupled to the at least one memory to perform a de-priming process of a patient undergoing a dialysis treatment via a dialysis machine operably coupled to the apparatus, the logic to2. The apparatus of claim 1 , the logic to measure a blood characteristic after the de-priming period claim 1 , the blood characteristic comprising at least one of a hematocrit level or a hemoglobin (Hgb) level.3. The apparatus of claim 1 , the de-priming ultrafiltration rate comprising ...

SYSTEMS AND METHODS FOR RETURNING TREATED MONONUCLEAR CELLS TO A BLOOD SOURCE

A method for treating mononuclear cells for an extracorporeal photopheresis procedure, driven and adjusted by a microprocessor-based controller, comprising the steps of priming a fluid circuit with priming fluid, directing whole blood derived from a blood source into the fluid circuit, separating the whole blood into a red blood cell component, a mononuclear cell component, and a plasma component, returning a first portion of the red blood cell component and a first portion of the plasma component to the whole blood, adding a photoactivation agent to the mononuclear cell component to create an agent-added mononuclear cell component, irradiating the agent-added mononuclear cell component to create a photoactivated mononuclear cell component, and incubating for a period of time a first portion of the photoactivated mononuclear cell component to create an incubated photoactivated mononuclear cell component. 1. A method for treating mononuclear cells for an extracorporeal photopheresis procedure , driven and adjusted by a microprocessor-based controller , comprising the steps of:priming a fluid circuit with priming fluid;directing whole blood derived from a blood source into the fluid circuit;separating the whole blood into a red blood cell component, a mononuclear cell component, and a plasma component;returning a first portion of the red blood cell component and a first portion of the plasma component to the whole blood;adding a photoactivation agent to the mononuclear cell component to create an agent-added mononuclear cell component;irradiating the agent-added mononuclear cell component to create a photoactivated mononuclear cell component; andincubating for a period of time a first portion of the photoactivated mononuclear cell component to create an incubated photoactivated mononuclear cell component.2. The method of claim 1 , further comprising:retaining a second portion of the red blood cell component and a second portion of the plasma component within the fluid ...

Priming System and Method for Dialysis Systems

The application is directed to an extracorporeal blood processing system capable of using dialysate to prime the system. A plastic molded compact manifold supports molded blood and dialysate fluidic pathways along with relevant sensors, valves and pumps. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine. A two-way valve in the manifold is used to direct the dialysate flow through the blood circuit to prime the circuit for use in treatment. 1. A priming process for priming a manifold within a dialysis machine for use in a dialysis treatment , comprising the steps of:a. Inserting said manifold into the dialysis machine, wherein said manifold comprises a substrate defining a first circuit and a second circuit and a compressible valve structure in fluid communication with each of said first and second circuits, wherein said valve structure has a first state and a second state and wherein, when in said first state, fluid from the first circuit cannot enter into the second circuit and when in said second state, fluid from the first circuit can enter into the second circuit;b. Placing said valve in said second state by removing pressure from said compressible valve structure;c. Pumping fluid through said first and second circuits;d. Placing said valve in said first state by applying pressure to said compressible valve structure; ande. Removing fluid from said second circuit.2. The priming process of wherein the first circuit is a dialysate circuit and wherein the second circuit is a blood circuit.3. The priming process of wherein the fluid is dialysate and wherein claim 2 , in said second state claim 2 , the dialysate flows through the dialysate circuit and into the blood circuit.4. The priming process of wherein the dialysate is removed from the blood circuit upon completion of the priming process.5. The priming process of wherein the dialysate is pumped from a dialysate reservoir and not from a separate ...

EXTRACORPOREAL OXYGENATOR WITH INTEGRATED AIR REMOVAL SYSTEM

Extracorporeal blood flow circuit devices can be used during medical procedures such as on-pump open-heart surgery. For example, extracorporeal heat exchange and oxygenation devices can be used to facilitate surgical procedures such as coronary artery bypass grafting. In some embodiments, such an oxygenation device can include an integrated air removal structure. In particular embodiments, the air removal structure can comprise one or more porous hollow fibers. 1. A blood oxygenator apparatus , comprising:a blood inlet and a blood outlet, a blood flow path extending from the blood inlet to the blood outlet;a gas exchange portion disposed along the blood flow path;a heat exchange portion disposed along the blood flow path prior to the gas exchange portion; andone or more porous hollow fibers disposed along the blood flow path prior to the heat exchange portion.2. The blood oxygenator apparatus of claim 1 , wherein an inside of the one or more porous hollow fibers is communicative to an ambient space within or around the blood oxygenator apparatus.3. The blood oxygenator apparatus of claim 1 , wherein an inside of the one or more porous hollow fibers is communicative to a vacuum source.4. The blood oxygenator apparatus of claim 1 , further comprising a flow distribution element disposed along the blood flow path prior to the one or more porous hollow fibers.5. The blood oxygenator apparatus of claim 4 , wherein the one or more porous hollow fibers are wound around the flow distribution element.6. The blood oxygenator apparatus of claim 5 , wherein the one or more porous hollow fibers are wound around the flow distribution element in a crisscrossing helical pattern.7. The blood oxygenator apparatus of claim 4 , wherein the one or more porous hollow fibers are disposed around the flow distribution element in a non-crossing pattern.8. The blood oxygenator apparatus of claim 1 , wherein pores of the one or more porous hollow fibers allow air to enter an inside of the one ...

MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME, AND DATA MANAGEMENT SYSTEMS AND METHODS

A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously-collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed. 154.-. (canceled)55. A disposable fluid circuit configured to interface with a hardware component to form an automated blood collection system for collecting red blood cells and plasma from a donor comprising , the disposable component comprising:a donor access device for withdrawing whole blood from a donor;a whole blood collection container in communication with the donor access device;a blood separation device communicating with the whole blood collection container and employing relatively rotating surfaces, at least one of which carries a membrane substantially permeable to plasma and substantially impermeable to red blood cells to separate the whole blood into substantially concentrated red cells and plasma;a first collection container communicating with the blood separation device for receipt of the substantially concentrated red blood cells;a source of preservative solution communicating with the first collection container; anda second collection container communicating with the blood separation chamber for receipt of the ...

Filling device of a fluid system

Disclosed is a filling device of a fluid conducting system of an extracorporeal blood treatment device that includes a spike for connecting to the single fluid connector of a medical fluid container and a manually operable fluid blocking mechanism arranged directly downstream of the spike that fluidly connects with the spike while the filling device is in operation. The fluid blocking mechanism has at least one fluid outlet connector that is adapted so that a line section or hose of the fluid conducting system such as the arterial line section of a blood purification device can be connected to it in a detachable manner while the filling device is in operation.

METHOD FOR PRIMING AN EXTRACORPOREAL BLOOD CIRCUIT OF AN APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD AND APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD

A method for priming an extracorporeal blood circuit of an apparatus for extracorporeal treatment of blood comprises: feeding a priming fluid in the extracorporeal blood circuit and into a blood side of a membrane gas exchanger (); generating a transitory pressurization step or a plurality of transitory pressurization steps in the priming fluid flowing in the blood circuit and in the blood side of the membrane gas exchanger (). 115-. (canceled)17. The method according to claim 16 , wherein the apparatus for extracorporeal treatment of blood comprises a blood treatment unit and the extracorporeal blood circuit is coupled to the blood treatment unit claim 16 , wherein the membrane gas exchanger is located next to the blood treatment unit.18. The method according to claim 17 , wherein the membrane gas exchanger is located substantially at the same height of the blood treatment unit claim 17 , and wherein the method comprises placing a priming fluid waste bag at the same height of the membrane gas exchanger or below the membrane gas exchanger.19. The method according to claim 17 , wherein the apparatus for extracorporeal treatment of blood comprises a disposable cartridge including the membrane gas exchanger claim 17 , the blood treatment unit claim 17 , and at least part of the extracorporeal blood circuit.20. The method according to claim 16 , comprising: repeating the transitory pressurization step during priming at time intervals claim 16 , wherein each time interval is between 10 s and 100 s.21. The method according to claim 16 , wherein a maximum pressure at the membrane gas exchanger during the pressurization step is between 100 mmHg and 1000 mmHg.22. The method according to claim 16 , wherein a time length of each pressurization step is between 2 s seconds and 30 s seconds claim 16 , wherein the time length of each pressurization step is a function of a pressure in the blood circuit measured downstream the blood pump or is being fixed.23. The method according to ...

Venting system with a venting unit and a venting device set and method of operating a venting system

A deaerating device set allows a priming circuit to be deaerated fully automatically using a deaerating unit and a priming control unit, a priming liquid container and preferably a priming pump or a priming compressor. A blood pump is operated in a pulsatile manner during the pumping of a priming fluid.

ARTERIAL AIR CAPTURE CHAMBER

An arterial air capture chamber () is used in dialysis. The arterial air capture chamber () includes an upwardly extending fluid inlet () terminating in a fluid inlet port () positioned at about a 90° turn relative to a fluid flow of a fluid inlet tube (). The arterial air capture chamber () includes a draw tube () with an opposedly positioned beveled opening () at about 180° relative to the fluid inlet port (). The arterial air capture chamber () provides improved fluid dynamics, reducing both stagnant flow and turbulence. The arterial air capture chamber () also provides for bidirectional flow of fluid through the arterial air capture chamber (). 1. An arterial air capture chamber , comprising:a chamber body having a top portion and a bottom portion;a fluid inlet positioned on the bottom portion of the chamber body, the fluid inlet upwardly extending from the bottom portion to form a fluid inlet tube terminating in a fluid inlet port disposed on an inner wall of the chamber body, the fluid inlet port positioned at about a 90° turn relative to a fluid flow of the tube and disposed tangential to a circle plane formed by a center axis of the chamber body; anda fluid outlet positioned on the top portion of the chamber body, the fluid outlet downwardly extending to form a draw tube extending from a top portion of the chamber body to the bottom portion of the chamber body; the draw tube terminating in a beveled opening, said beveled opening opposedly positioned on the draw tube at about 180° relative to the fluid inlet port.2. The arterial air capture chamber of claim 1 , further comprising a spiral flow-inducing shelf flush to a bottom portion of the fluid inlet port claim 1 , said spiral-flow inducing shelf disposed on the inner wall of the chamber on the circumference of the circle plane formed by the center axis of the chamber body claim 1 , said shelf downwardly extending to the bottom of the chamber body.3. The arterial air capture chamber of claim 2 , wherein the ...

Method for filling and rinsing a set of blood lines

A method for the filling and flushing of a blood tube set including a pump segment for a blood pump, an arterial line connected to an inlet of a dialyser, a venous line connected to an outlet of a dialyser, a substituate line connected to a substitute port and having a pump segment for a substitute pump, and a three-way connector connected to the arterial line, the venous line and a rinse port. The method includes the steps of opening the rinse port, filling and simultaneously flushing the arterial and venous lines with the substituate supplied from the substitute line via the substitute pump, while substituate is drained off via the rinse port, closing the rinse port, and circulating the substituate in the circuit of arterial line, dialyser and venous line by the blood pump.

Method and control apparatus for determining and adjusting a flow rate of a blood delivery pump

Flow rate of a blood delivery pump of a blood treatment apparatus is determined and adjusted by connecting a fluid filled container with an extracorporeal blood line of the blood treatment apparatus, performing a priming step to prime the extracorporeal blood line by driving the blood delivery pump at a predetermined theoretical delivery rate to deliver fluid from the filled container into the extracorporeal blood line, determining the loss of fluid of the fluid filled container due to delivery of fluid into the extracorporeal blood line during priming, and determining a correction factor by comparison of a value for an amount of fluid delivered under the theoretical delivery rate with a value for the amount of fluid actually delivered.

BLOOD TREATMENT FILTER DEVICE, PRIMING METHOD, AND BLOOD TREATMENT METHOD

To provide a blood treatment filter device capable of efficiently utilizing a blood treatment filter. 17-. (canceled)8. A priming method for a blood treatment filter device having:a body container which has a first port and a second port which are continuous to an internal space and which is disposed with the first port located above the second port in a gravity direction;a blood treatment filter in a dry state placed in the internal space of the body container;a first blood circuit which is connected to the first port and through which liquid flows;a second blood circuit which is connected to the second port and through which liquid flows;a first bypass circuit which is connected to the first blood circuit and the second blood circuit and through which liquid flows; anda second bypass circuit which is connected to a side closer to the first port relative to a connection position of the first bypass circuit in the first blood circuit and is connected to a side further from the second port relative to a connection position of the first bypass circuit in the second blood circuit and through which liquid flows,the priming method comprising:individually closing the circuit between a connection position of the first bypass circuit and a connection position of the second bypass circuit in each of the first blood circuit and the second blood circuit to cause a priming liquid to flow into the internal space of the body container from the first blood circuit through the first bypass circuit, the second blood circuit,and the second port, and then to cause the priming liquid to flow out of the internal space of the body container to the second blood circuit through the first port, the first blood circuit, and the second bypass circuit.9. The priming method for the blood treatment filter device according to claim 8 , whereinthe blood treatment filter has a sheet shape and is placed in the body container in a cylindrically wound state, andthe body container has a liquid flow ...

Methods and systems for priming a biological fluid processing circuit

Methods and systems for priming biological fluid processing systems are disclosed. In accordance with such methods and systems, the disposable fluid processing circuit is primed by introducing a first priming solution into a portion of the circuit and a second priming solution into a portion of the circuit. The amount of citrate returned to the biological flood source is minimized.

Modular Blood Treatment Systems, Units, and Methods

A portable adapter is provided that can include a closure system configured to control the flow of blood and/or dialysate between the adapter and a blood treatment apparatus. Modular systems are also provided that include the portable adapter engaged with various units such as a portable blood processing module, a non-portable base module, and/or a remote module. Methods of conducting blood treatments such as blood circulation, hemodialysis, and hemofiltration, hemodiafiltration, using the modular systems are also provided. The systems, units, and methods enable the engagement and disengagement of the adapter from the various units to conduct, interrupt, and resume blood treatments without disconnecting the adapter from the vasculature of a patient. Modular systems including interchangeable portable and base modules configured for various blood treatments are also provided that can be engaged and disengaged with each other without disconnecting the portable module from the vasculature of a patient. 1. A portable blood circuit adapter comprising:an extracorporeal blood circuit tubing set comprising a to-patient venous line and a from-patient arterial line, each of the venous line and arterial line having an adapter end and a patient end configured to connect with a vascular access or vascular access implant;an adapter housing comprising a module connector configured to engage a complementary inter-module connector of a blood treatment apparatus that comprises a blood pump configured to pump blood extracorporeally through the extracorporeal blood circuit tubing set, the adapter housing comprising tube connectors for fixing the adapter ends of the venous line and the arterial line to the adapter housing, the tube connectors being in fluid communication with the module connector and providing interruptible fluid flow paths between the venous line and the module connector and between the arterial line and the module connector; anda closure system mounted in or on the ...

BLOOD RINSEBACK SYSTEM AND METHOD

A hemodialysis system is provided and includes a dialyzer, a dialysis fluid circuit in fluid communication with the dialyzer, a blood circuit, a blood detector and a blood rinseback scheme, wherein the blood rinseback scheme includes transferring blood to the patient using a physiologically acceptable fluid, wherein the physiologically acceptable fluid is introduced from its source into an arterial line between an arterial line patient end and a blood pump of the blood circuit, and flowed through the dialyzer, through a venous drip chamber and to the blood detector along a venous line of the blood circuit, where the physiologically acceptable fluid is sensed by the blood detector to indicate an end of the blood rinseback. 1. A hemodialysis system configured to return blood to a patient , the hemodialysis system comprising:a dialyzer; a fresh dialysis fluid pump,', 'a used dialysis fluid pump,', 'a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and', 'a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;, 'a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including'} an arterial line for removing blood from a patient and delivering the blood to the dialyzer,', 'a venous line for returning blood from the dialyzer to the patient,', 'a blood pump operable with the arterial line upstream of the dialyzer,', 'a physiologically acceptable fluid source in fluid communication with the arterial line between a patient end of the arterial line and the blood pump,', 'a drip chamber located along the venous line;, 'a blood circuit in fluid communication with the dialyzer and including'}a ...

SYSTEMS AND METHODS FOR PRIMING HEMODIALYSIS USING MULTIPLE FLUID SOURCES

A hemodialysis system configured to purge air from a blood circuit comprising: a dialyzer; a dialysis fluid circuit operable with the dialyzer via dialysis fluid inlet and outlet lines; the blood circuit operable with the dialyzer and including an arterial line, a venous line, a blood pump operable with the arterial line upstream of the dialyzer, and a physiologically acceptable fluid source in fluid communication with the arterial line upstream of the blood pump; and an air purging scheme wherein, with the dialysis fluid inlet and outlet lines connected to the dialyzer, air is purged using dialysis fluid or other physiologically acceptable fluid pumped by at least one of the fresh or used dialysis fluid pumps from the dialysis fluid circuit, through the dialyzer, into the blood circuit, in combination with dialysis fluid or other physiologically acceptable fluid from the source introduced directly into the blood circuit. 1. A hemodialysis system configured to purge air from a blood circuit , the hemodialysis system comprising:a dialyzer; a fresh dialysis fluid pump,', 'a used dialysis fluid pump,', 'a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and', 'a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;, 'a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including'} an arterial line for removing blood from a patient and delivering the blood to the dialyzer,', 'a venous line for returning blood from the dialyzer to the patient,', 'a blood pump operable with the arterial line upstream of the dialyzer,', 'a physiologically acceptable fluid source in fluid communication ...

AIR PURGING SYSTEMS FOR BLOOD TREATMENTS

A hemodialysis system configured to purge air from a blood circuit comprises a dialyzer; a dialysis fluid circuit operable with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including a fresh dialysis fluid pump, and a used dialysis fluid pump; the blood circuit operable with the dialyzer and including an arterial line, a venous line, a blood pump operable with the arterial line upstream of the dialyzer, a physiologically acceptable fluid source in fluid communication with the arterial line upstream of the blood pump, a drip chamber located along the venous line, and a container for accepting air purged from the blood circuit; and an air purging scheme wherein, with the dialysis fluid inlet and outlet lines connected to the dialyzer, the blood pump pumps a fluid through the dialyzer and into the drip chamber, forcing air from the drip chamber into the container. 1. A hemodialysis system configured to purge air from a blood circuit , the hemodialysis system comprising:a dialyzer; a fresh dialysis fluid pump,', 'a used dialysis fluid pump,', 'a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and', 'a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;, 'a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including'} an arterial line for removing blood from a patient and delivering the blood to the dialyzer,', 'a venous line for returning blood from the dialyzer to the patient,', 'a blood pump operable with the arterial line upstream of the dialyzer,', 'a physiologically acceptable fluid source in fluid communication with the arterial line ...

SYSTEM AND METHOD FOR COLLECTING PLASMA

A method for collecting plasma includes determining the weight, height, and hematocrit of a donor, and calculating a donor plasma volume and a target plasma collection volume. The target plasma collection volume is based on the donor plasma volume and a target percentage of plasma. The method then withdraws blood from the donor through a line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate the volume of pure plasma collected within the plasma collection container, and continue processing/collecting until the calculated volume of pure plasma equals the target plasma collection volume. 1. A system for collecting plasma , comprising:a venipuncture needle configured to draw whole blood from a donor;a blood separator configured to separate the whole blood into a plasma product and a second blood component comprising red blood cells, the blood separator having a plasma output port coupled to a plasma line configured to send the plasma product to a plasma product collection container;a donor line fluidly coupled to the venipuncture needle configured to introduce the whole blood from the donor to the blood separator, flow through the donor line being controlled by a first pump;an anticoagulant line coupled to an anticoagulant source, the anticoagulant line configured to combine anticoagulant with the whole blood from the donor, flow through the anticoagulant line being controlled by a second pump;a touchscreen configured to receive input from an operator; anda controller programmed to control operation of the system, the controller coupled to the touchscreen and programmed to receive at least a donor's weight and hematocrit, to determine a target volume for ...

VENOUS AIR CAPTURE CHAMBER

A venous air capture chamber for use in dialysis, includes an upwardly extending fluid inlet terminating in first and second fluid inlet ports (). The first and second fluid inlet ports () are opposedly positioned on the fluid inlet at an angle of about 180°. The venous air capture chamber also includes a fluid outlet () at the bottom of the chamber body. The venous air capture chamber provides improved fluid dynamics, reducing both stagnant flow and turbulence. The venous air capture chamber also provides for bidirectional flow of fluid through the chamber. 1. A venous air capture chamber , comprising:a chamber body comprising a top portion and a bottom portion;a fluid inlet upwardly extending from the bottom portion of the chamber body towards the top portion of the chamber body to form a fluid inlet tube terminating in a first fluid inlet port and a second fluid inlet port; wherein the first fluid inlet port and the second fluid inlet port are tangential to a circle plane formed by a center axis of the chamber body; wherein the first fluid inlet port and second fluid inlet port are opposedly positioned on the fluid inlet at an angle of about 180°; anda fluid outlet on the bottom portion of the chamber body.2. The venous air capture chamber of claim 1 , wherein the first fluid inlet port and second fluid inlet port are positioned at about a 90° turn relative to a fluid flow of the tube.3. The venous air capture chamber of claim 1 , wherein the fluid outlet comprises a mesh filter forming a cylindrical taper having a decreasing diameter in an upwardly direction from the bottom of the chamber and terminates in a substantially planar surface.4. The venous air capture chamber of claim 1 , wherein the chamber body is a substantially ovoid5. The venous air capture chamber of claim 1 , wherein the chamber body comprises a small cylinder portion and a large cylinder portion; wherein the large cylinder portion is positioned higher relative to the large cylinder portion of ...

Blood Treatment Device Priming Devices, Methods, and Systems

Simple-to-use systems, methods, and devices for priming replacement blood treatment devices, for swapping the blood treatment devices out, for replacing swapped-out blood treatment devices, and other related operations are described. In embodiments, a blood treatment device can be primed while a therapy is still running. When the replacement blood treatment device is needed, the therapy can be stopped momentarily (less than a minute) for the rapid and safe swap of the blood treatment device. Blood loss can be minimized. The down time from therapy can be minimized. 1. A method for performing a blood treatment , comprising:flowing blood from a patient through an extracorporeal blood treatment system that uses a replaceable blood treatment device;detecting a condition indicating a need to replace the replaceable blood treatment device;priming a blood treatment device to provide a primed blood treatment device; andreplacing the replaceable blood treatment device with the primed blood treatment device.2. The method of claim 1 , wherein the detecting includes detecting a change in a pressure of a blood circuit.3. The method of claim 2 , wherein the detecting includes detecting a pressure property indicating a rise in pressure drop through the replaceable blood treatment device.4. The method of claim 1 , wherein the flowing includes performing a hemodialysis claim 1 , hemofiltration claim 1 , apheresis claim 1 , or a type of renal replacement therapy treatment.5. The method of claim 1 , wherein the priming includes creating a siphon flow in a priming circuit and automatically halting the siphoning flow prior to an entry of air or other gas or gasses into a fluid circuit of the extracorporeal blood treatment system.6. The method of claim 5 , wherein the automatically halting includes a passive starvation of a flow from a priming source.7. The method of claim 5 , wherein the automatically halting includes a complete filling of a fluid-receiving device until it can hold no ...

Blood circuit adapter set and blood circuit

An adapter set that is attached to artery-side and vein-side shunt connectors-that are provided on a blood circuit. The adapter set includes: an artery-side adapter that has one end thereof connected to the artery-side shunt connector, has the other end thereof connected to a drainage port that is provided on the outside of the blood circuit, and thereby connects the artery-side shunt connector and the drainage port fluid tight; and a vein-side adapter that has one end thereof connected to the vein-side shunt connector, has the other end thereof connected to a supply port that is provided on the outside of the blood circuit, and thereby connects the vein-side shunt connector and the supply port fluid tight. The structure of the other end of the artery-side adapter and the structure of the other end of the vein-side adapter are different.

Cartridges and Systems for Outside-In Flow in Membrane-Based Therapies

Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration. These various features may enable long-term application to all dialysis and ultrafiltration related therapies, and also to other therapies and to applications including implantables, portables and wearables.

DIALYSIS SYSTEM AND METHODS

Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration. 1. A method of priming a tubing set and a dialyzer of a dialysis system , comprising the steps of:connecting an arterial line of the tubing set to a venous line of the tubing set to form a continuous loop in the tubing set;operating a blood pump of the dialysis system to flow saline from a saline source into the arterial line and into a blood-side of the dialyzer and into a venous drip chamber; andoperating the blood pump in a reverse mode to flow saline from the venous drip chamber into the blood-side of the dialyzer in a direction opposite to a direction of blood flow during dialysis therapy.2. The method of claim 1 , further comprising:monitoring a fluid level of the saline in a venous drip chamber of the tubing set; andstopping operation of the blood pump when the fluid level in the venous drip chamber stabilizes.3. The method of claim 1 , further comprising:monitoring the tubing set for the presence of air; andstopping operation of the blood pump when air no longer ...

Blood Treatment Device Priming Devices, Methods, and Systems

Simple-to-use systems, methods, and devices for priming replacement blood treatment devices, for swapping the blood treatment devices out, for replacing swapped-out blood treatment devices, and other related operations are described. In embodiments, a blood treatment device can be primed while a therapy is still running. When the replacement blood treatment device is needed, the therapy can be stopped momentarily (less than a minute) for the rapid and safe swap of the blood treatment device. Blood loss can be minimized. The down time from therapy can be minimized. 1. A method of preparing a blood circuit element , comprising:connecting a priming fluid container of priming fluid to a blood treatment device blood inlet and connecting a drain container to a blood treatment device blood outlet;the connecting includes selecting a drain container with an internal volume that is less than a volume of priming fluid in the priming fluid container plus an internal volume of the blood treatment device and connections between the blood treatment device and the priming fluid and container and drain container;elevating the priming fluid container above the drain container to cause a flow of priming fluid through the blood treatment device into the drain container to flush and fill the blood treatment device with priming fluid; andhalting a flow of priming fluid by permitting the flow to continue until the drain container is full, thereby causing the flow to stop by supporting a fluid column between the fluid in the priming fluid container and a bottom of the drain container.2. The method of claim 1 , further comprising disconnecting the blood treatment device and connecting it to a blood treatment system.3. The method of claim 2 , wherein the disconnecting includes sealing fluid lines connected to the blood treatment device.4. The method of claim 3 , wherein the sealing includes disconnecting self-sealing connectors of a fluid circuit connected to the blood treatment device.5. A ...

AUTOMATED PRE-FILTRATION AIR MANAGEMENT AND FILTRATION SYSTEMS AND METHODS

Filtration systems and methods using a pump and pressure sensor are provided for improved efficiency in fluid filtration systems. A filtration system includes a pre-filter container joined to a post-filter container by a filter line having a filter. To reduce the time required for filtration a pump and pressure sensor are included in a filter inlet flow path. The pump also is used to provide air management in the system via pre-filtration evacuation of air from at least the filter. 113-. (canceled)14. A method of filtering a fluid , comprising:providing a pre-filter container; providing a post-filter container;providing a filter line having a filter between the pre-filter container and the post-filter container;providing a pump and a pressure sensor in communication with the pre-filter container and the filter;flowing air from at least the filter into the pre-filter container; andflowing a fluid from the pre-filter container, through the pump and filter line, and into the post-filter container.15. The method of claim 14 , further comprising flowing air from at least a portion of the filter line between the filter and the post-filter container into the pre-filter container.16. The method of claim 14 , further comprising providing a second pump and pressure sensor in communication with the filter and the post-filter container.17. The method of claim 14 , wherein the filter line further comprises a filter inlet flow path and a filter outlet flow path claim 14 , and the method further comprises providing a bypass flow path between the filter outlet flow path and the filter inlet flow path claim 14 , and permitting air in the bypass flow path to move into the filter inlet flow path wherein the air assists in moving fluid through the filter.18. The method of claim 14 , wherein the flowing of the fluid from the pre-filter container claim 14 , through the pump and filter line claim 14 , and into the post-filter container advances automatically after the step of flowing air ...

METHOD FOR AUTOMATED PRIMING OF AN EXTRACORPOREAL BLOOD CONDUIT SYSTEM, AND A DEVICE FOR SAME

A method and apparatus for priming an extracorporeal blood system. The extracorporeal blood system includes an arterial blood line, a venous blood line, a pump segment for interaction with a peristaltic blood pump of the apparatus and a blood treatment unit. A port of the venous blood line is connected to a venous blood port of the blood treatment unit. A port of the arterial blood line is connected to an arterial blood port of the blood treatment unit. The extracorporeal blood system is connected to a reservoir containing priming liquid. The non-occluded extracorporeal blood system is subsequently filled with priming liquid and, after filling with priming liquid, the pump segment is automatically occluded by a blood pump. 1. A method of priming an extracorporeal blood system , the extracorporeal blood system comprising an arterial blood line , a venous blood line , a pump segment for interaction with a blood pump of the apparatus , and a blood treatment unit , the method comprising the steps of:connecting a port of the venous blood line to a venous blood port of the blood treatment unit;connecting a port of the arterial blood line to an arterial blood port of the blood treatment unit;connecting the extracorporeal blood system to a reservoir containing priming liquid; andfilling the extracorporeal blood system with priming liquid,the pump segment being inserted into or positioned relative to the blood pump prior to filling with priming liquid so that during filling of priming liquid into the extracorporeal blood system, the pump segment is not occluded by the blood pump and, after complete filling of the extracorporeal blood system with priming liquid, the pump segment is automatically placed and occluded in the delivery path of the blood pump by activating the blood pump.2. The method according to claim 1 , wherein the extracorporeal blood system is connected to the reservoir containing priming liquid claim 1 , as a patient-side port of the venous blood line or a ...

SYSTEMS AND METHODS FOR PRIMING HEMODIALYSIS USING DIALYSIS FLUID

A method for priming a hemodialysis treatment includes: providing a disposable cassette including at least a portion of a dialysate circuit and at least a portion of a blood circuit; placing a dialyzer in fluid communication with the dialysate circuit via a to-dialyzer dialysate line and a from-dialyzer dialysate line; placing the dialyzer in fluid communication with the blood circuit via an arterial blood line and a venous blood line; placing a source of dialysis fluid in fluid communication with the dialyzer; priming the dialysate circuit with dialysis fluid from the source while both the to-dialyzer dialysate line and the from-dialyzer dialysate line are connected at their dialyzer ends to the dialyzer; and priming the blood circuit with dialysis fluid from the source by actuating at least one valve provided by the disposable cassette. 1. A method for priming a hemodialysis treatment comprising:providing a disposable cassette including at least a portion of a dialysate circuit and at least a portion of a blood circuit;placing a dialyzer in fluid communication with the dialysate circuit via a to-dialyzer dialysate line and a from-dialyzer dialysate line;placing the dialyzer in fluid communication with the blood circuit via an arterial blood line and a venous blood line;placing a source of dialysis fluid in fluid communication with the dialyzer;priming the dialysate circuit with dialysis fluid from the source while both the to-dialyzer dialysate line and the from-dialyzer dialysate line are connected at their dialyzer ends to the dialyzer; andpriming the blood circuit with dialysis fluid from the source by actuating at least one valve provided by the disposable cassette.2. The method of claim 1 , wherein priming the blood circuit includes reversing a blood pump at least one time.3. The method of claim 2 , which includes reversing the blood pump after a drip chamber is filled with fluid.4. The method of claim 1 , wherein priming the blood circuit includes connecting ...

System and Method for the Re-Anticoagulation of Platelet Rich Plasma

A method for the re-anticoagulation of platelet rich plasma in a blood apheresis system includes priming the blood apheresis system with anticoagulant, such that a volume of anticoagulant is transferred to a PRP container. The method may then transfer the anticoagulant within the PRP container to a red blood cell container, and collect a volume of platelet rich plasma within the PRP container. The platelet rich plasma may be collected in a plurality of cycles. Between collection cycles, the method may transfer a portion of the volume of anticoagulant from the red blood cell container to the PRP container.

Rotary Valves for Dialysis Systems

In one aspect, a dialysis fluid cassette includes an inlet fluid line, multiple outlet fluid lines, and a valve including an actuation feature by which the valve can be rotated to fluidly communicate the inlet fluid line with a selected fluid line of the multiple outlet fluid lines.

Systems and methods for collection of red blood cells

A method and system for collecting a double volume of red blood cells using a spinning membrane separator is provided by which a first quantity of whole blood is withdrawn from a donor; a first quantity of whole blood is flowed to the spinning membrane separator; where it is separated into a first quantity of red blood cells and a first quantity of plasma. The first quantity of red blood cells and the first quantity of plasma are then flowed to respective collection containers, and at least a portion of the first quantity of plasma is returned to the donor. A second quantity of whole blood withdrawn from the donor, and then separated into a second quantity of red blood cells and a second quantity of plasma using the spinning membrane separator. The second quantity of red blood cells and the second quantity of plasma are then flowed to the respective collection containers, and at least a portion of the second quantity of plasma is returned to the donor.

Dialyzer Holder And Improved Airless Bloodline Priming Method

The present invention relates to a dialyzer holder to attach a dialyzer to a dialysis machine. During priming of a bloodline prior to a dialysis treatment, the dialyzer holder grips a dialyzer in approximately the center of the dialyzer, but allows movements of the dialyzer in an arc motion using two axes of rotation. The holder enables the dialyzer to move to a position where air can be primed from the dialyzer and, because the dialyzer can move toward the dialysis machine, this motion eliminates stress on the tubing connected to the bottom and top of the dialyzer and reduces the length of bloodline tubing necessary to accommodate dialyzer movement. The dialyzer holder incorporates an attachment point for a venous chamber for use during the priming procedure, enabling the venous chamber to move with the dialyzer, further reducing the tubing between the dialyzer and the venous chamber.

Vial Spiking Assemblies and Related Methods

This disclosure relates to vial spiking assemblies and related methods. In certain aspects, the vial spiking assemblies include a vial adapter having a base, a spike extending from a central region of the base, and a sidewall extending from the base and surrounding the spike. The base and the sidewalls partially, define a cavity that is configured to receive at least a portion of the vial. The assemblies also include a spike cover that is removably attached to the spike and that includes a material configured to indicate when the material is contacted with liquid.

Blood treatment air purging system and method

A blood treatment air purging system and method includes a level detector positioned and arranged to detect a low fluid level in a blood circuit indicating a high amount of air in the blood circuit; a blood pump operable with the blood circuit; a venous patient line of the blood circuit; and at least one blood circuit air vent valve, wherein the system and method are configured or programmed to (i) stop the blood pump, (ii) close the venous patient line, and (iii) open the at least one blood circuit air vent valve to atmosphere or a container when the low fluid level is detected, and (iv) run the blood pump to meter air through the at least one blood circuit air vent valve to atmosphere or the container.

DEVICE WITH A BAG-SHAPED CONTAINER AND METHOD FOR FILLING A PUMP-OPERATED HOLLOW LINE-SUPPORTED LIQUID CIRCUIT WITHOUT FORMING GAS BUBBLES USING THE DEVICE

The invention relates to a container in the form of a bag having a flexible bag wall at least in a region, in which a first and a second hollow channel section, pass through the bag wall in a fluid-tight manner, wherein the hollow channel sections respectively have an open channel end that is located within the container for connecting the open channel ends to one another in a separable and fluid-tight manner. 119-. (canceled)20. A device comprising: a container formed as a bag , which is having a bag wall which is flexible at a region , in which a first and a second hollow channel section , pass through the bag wall in a fluid-tight manner , with the hollow channel sections each having an open channel end that is located within the bag for connecting the open channel ends to one another in a separable and fluid-tight manner;a first filter insert within the bag and at least partially encompassing a first inner filter volume with a first filter wall within another volume that is at least partially encompassed by the bag, a bag volume, with a tubular fluid line section passing through the first filter wall which is connected thereto, and with the fluid line section being open on two and leading into the first filter volume, and into the bag volume, and whereina channel end of the first hollow channel section, which is located within the bag, and being connectable to the open fluid line section leading into the bag volume in a separable and fluid-tight manner.21. The device according to claim 20 , wherein:a second filter insert is within the first filter volume and at least partially encloses a second filter volume with a second filter wall, into which the fluid line section leads into the first filter volume, and the second filter wall is connected on the fluid line section in a fluid-tight manner.22. The device according to claim 20 , wherein:the first and second hollow channel sections respectively have a channel end that is located outside the bag and are connected ...

APPARATUS AND METHOD FOR BATCH PHOTOACTIVATION OF MONONUCLEAR CELLS

An apparatus and method for the batch photoactivation of mononuclear cells (MNCs) is described. The system includes a programmable controller configured to automatically separate whole blood in a first collection cycle to obtain a first quantity of MNCs; separate whole blood in a second collection cycle to obtain a second quantity of MNCs while simultaneously photoactivating the first quantity of MNCs to obtain a first quantity of treated MNCs; either store the first quantity of treated MNCs or reinfuse the first quantity of treated MNCs; photoactivate the second quantity of MNCs to obtain a second quantity of treated MNCs; either store the second quantity of treated MNCs or reinfuse the second quantity of treated MNCs; and reinfuse any blood components remaining after the second collection cycle. 1. A method for the batch photoactivation of mononuclear cells (MNCs) comprising:a) separating whole blood in a first collection cycle to obtain a first quantity of MNCs;b) separating whole blood in a second collection cycle to obtain a second quantity of MNCs while simultaneously photoactivating the first quantity of MNCs to obtain a first quantity of treated MNCs;c) either storing the first quantity of treated MNCs or reinfusing the first quantity of treated MNCs;d) photoactivating the second quantity of MNCs to obtain a second quantity of treated MNCs;e) either storing the second quantity of treated MNCs or reinfusing the second quantity of treated MNCs; andf) reinfusing any blood components remaining after the second collection cycle.2. The method of wherein the method is performed with a blood separation system including a disposable fluid circuit having a separation chamber claim 1 , the first collection cycle further comprising: i) withdrawing whole blood from a patient; ii) priming the fluid circuit with whole blood; iii) introducing additional whole blood into the separation chamber for separation into plasma claim 1 , RBCs and MNCs; iv) transferring a portion of ...

Method for temporarily interrupting an extracorporeal blood treatment, control device and blood treatment apparatus

This disclosure relates to a method for temporarily interrupting an extracorporeal treatment of blood of a patient by use of a blood treatment apparatus. The method comprises activating or controlling a control device provided and configured to bring the blood treatment apparatus into a state in which the blood treatment of the patient can be interrupted with the intention to continue the blood treatment. This disclosure further relates to a control device, a blood treatment apparatus, a digital storage means, a computer program product as well as a computer program. 116-. (canceled)17. A control device being configured to be activated or controlled in order to temporarily interrupt a blood treatment being effected by a blood treatment apparatus or being configured to effect a temporary interruption of the blood treatment apparatus;wherein a patient is connected to the blood treatment apparatus via an extracorporeal blood circuit during the blood treatment;wherein the control device is configured to at least bring the blood treatment apparatus into a state in which the blood treatment can be interrupted temporarily with the ability to subsequently continue the blood treatment,wherein the control device is configured to induce a connection of an arterial line section and a venous line section of the extracorporeal blood circuit to a source of substitute or to advise a user to connect the arterial line section and the venous line section of the extracorporeal blood circuit to the source of substitute; andwherein the control device is further configured to induce or effect a circulation of at least one substitute liquid supplied from the source of substitute in the extracorporeal blood circuit when the blood treatment is temporarily interrupted.18. The control device according to claim 17 , wherein the control device is configured to induce or effect that the interrupted blood treatment is continued by at least one medical device that had been used before interruption ...

Blood treatment systems and methods

Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.

DIALYSIS SYSTEM AND METHODS

Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration. 1. A method of priming a tubing set and a dialyzer of a dialysis system , comprising the steps of:operating a blood pump of the dialysis system to flow saline from a saline source into the tubing set and into a blood-side of the dialyzer; andperiodically actuating one or more valves of the dialysis system with an electronic controller to open and close the tubing set to create a pulsing effect that dislodges air bubbles from the tubing set and dialyzer.2. The method of claim 1 , further comprising:monitoring a fluid level of the saline in a venous drip chamber of the tubing set; andstopping operation of the blood pump when the fluid level in the venous drip chamber stabilizes.3. The method of claim 1 , further comprising:monitoring the tubing set for the presence of air; andstopping operation of the blood pump when air no longer circulates through the tubing set.4. The method of claim 1 , further comprising operating a dialysate pump to flow dialysate from a dialysate source ...

Automated Extracorporeal Blood Treatment Apparatus

The present invention provides an extracorporeal dialysis apparatus which allows the automation of some operations in order to make possible a safe home treatment or to facilitate the treatment process for example the priming and/or the blood return process. Thus, the object is to automatically perform a series of processes from hemodialysis preparation to treatment completion safely, reliably and speedily, and to significantly reduce the labor and supply costs.

METHOD OF REMOVING BLOOD FROM AN EXTRACORPOREAL BLOOD CIRCUIT, TREATMENT APPARATUS, AND TUBE SYSTEM

The present invention relates to a method of removing blood from an extracorporeal blood circuit following termination of a blood treatment session, wherein blood is concurrently removed both from an arterial conduit portion and from a venous conduit portion of the extracorporeal blood circuit. It further relates to a method for recognizing and/or eliminating air inclusions in or from an extracorporeal blood circuit and a treatment apparatus as well as a tube system. 1. (canceled)2. A treatment apparatus comprising: a dialyzer;', 'a solution supply line connected to the dialyzer and a solution source;', 'an outlet line connected to the dialyzer;', 'an arterial conduit portion connected to the dialyzer; and', 'a venous conduit portion connected to the dialyzer and including a venous needle;, 'a fluid conveyance system comprisinga blood pump arranged along the fluid conveyance system and adapted to convey blood within the fluid conveyance system;a second pump arranged along the fluid conveyance system and adapted to pump a liquid, via a liquid feed conduit, into the fluid conveyance system at an addition site along fluid conveyance system; andat least one controller configured to concurrently remove blood, using the liquid pumped by the second pump into the fluid conveyance system while a patient is connected to the treatment apparatus, from both the arterial conduit portion and from the venous conduit portion of the fluid conveyance system.3. The treatment apparatus of claim 2 , wherein the arterial conduit portion includes an arterial patient tube clamp and the venous conduit portion includes a venous patient tube clamp.4. The treatment apparatus of claim 3 , wherein claim 3 , during the removal of blood from the arterial conduit portion and from the venous conduit portion claim 3 , both the arterial patient tube clamp and the venous patient tube clamp are in an opened state.5. The treatment apparatus of claim 2 , wherein the liquid pumped by the second pump into ...

DEVICES, METHODS, AND SYSTEMS FOR PRIMING, SEPARATING, AND COLLECTING BLOOD COMPONENTS

A photopheresis system () is disclosed, and that may be configured to execute one or more protocols. These protocols include: 1) protocols () for purging air out of a centrifuge bowl () used by the photopheresis system (); 2) protocols () for assessing the installation/operation of one or more pressure domes () used by the photopheresis system (200); and 3) protocols () for collecting buffy coat from blood processed by the photopheresis system (). 1. A method of operating a blood processing system , wherein said blood processing system comprises a centrifuge , and wherein said centrifuge comprises a first port and a second port , said method comprising:introducing blood into said centrifuge through said first port;separating said blood into a plasma layer, a buffy coat layer, and a red blood cell layer within said centrifuge and by rotating said centrifuge;executing a first monitoring step comprising monitoring a location of an interface between said buffy coat layer and said red blood cell layer within said centrifuge; said first condition requiring: 1) an amount of said blood introduced into said centrifuge being both less than a target processed blood volume and within a first predetermined amount of said target processed blood volume; and 2) a determination by said blood processing system that said interface is in a first position from said first monitoring step;', 'said second condition being said amount of said blood introduced into said centrifuge being larger than said target processed blood volume by at least a second predetermined amount; and, 'executing a second monitoring step comprising monitoring for an existence of a first condition and a second condition;'}directing a fluid flow out of said second port of said centrifuge and into a first container, wherein said fluid flow comprises buffy coat from said buffy coat layer, wherein said directing a fluid flow step is initiated in response to said blood processing system having identified an existence of ...

Dialysis system and methods

Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration.

Blood treatment filter device, priming method, and blood treatment method

To provide a blood treatment filter device capable of efficiently utilizing a blood treatment filter. A blood treatment filter device 20 has a filter sheet 26 through which a specific component among components forming blood is harder to pass than other components and a spacer sheet 27 through which the specific component is easier to pass than through the filter sheet 26 . The filter sheet 26 has filter through-holes 39 disposed at intervals. The filter sheet 26 and the spacer sheet 27 are spirally wound in an overlapped state. The filter device 20 has seals 31 sealing both end portions in the longitudinal direction of a wound body 25 formed by the filter sheet 26 and the spacer sheet 27 which are spirally wound in a fluid-tight manner. The outer peripheral surface of the wound body 25 is formed by the filter sheet 26.

HEMODIALYSIS SYSTEM INCLUDING A DISPOSABLE SET AND A DIALYSIS INSTRUMENT

A hemodialysis system is disclosed. The hemodialysis system includes a disposable set including a blood pumping tube, a fresh dialysate pumping tube, and a spent dialysate pumping tube. The hemodialysis system also includes a dialysis instrument including a blood pump head, a fresh dialysate pump head, a spent dialysate pump head, a first motor positioned and arranged to operate the blood pump head, a second motor positioned and arranged to operate the fresh dialysate pump head, and a third motor positioned and arranged to operate the spent dialysate pump head. When the disposable set is loaded into the dialysis instrument, the blood pumping tube comes into registry with the blood pump head, the fresh dialysate pumping tube comes into registry with the fresh dialysate pump head, and spent dialysate pumping tube comes into registry with the spent dialysate pump head. 1. A hemodialysis system comprising:a disposable set including a blood pumping tube, a fresh dialysate pumping tube, and a spent dialysate pumping tube; and a blood pump head,', 'a fresh dialysate pump head,', 'a spent dialysate pump head,', 'a first motor positioned and arranged to operate the blood pump head,', 'a second motor positioned and arranged to operate the fresh dialysate pump head,', 'a third motor positioned and arranged to operate the spent dialysate pump head, and', 'an interface for receiving the disposable set to enable the disposable set to be loaded into the dialysis instrument such that the blood pumping tube comes into registry with the blood pump head, the fresh dialysate pumping tube comes into registry with the fresh dialysate pump head, and spent dialysate pumping tube comes into registry with the spent dialysate pump head, and', 'a door providing access to the interface,, 'a dialysis instrument including'}wherein when the door is moved to a closed position, the blood pumping tube is operable with the blood pump head, the fresh dialysate pumping tube is operable with the fresh ...

SYSTEMS AND METHODS FOR PRIMING A FLUID CIRCUIT

Methods and systems for priming a disposable fluid circuit for the processing of a biological fluid are disclosed. The methods and systems allow for variable and configurable priming of the flow path(s) leading to one or more biological fluid source containers. 1. A method for priming at least a portion of a fluid circuit of a biological fluid processing system comprising:a. pumping a priming solution from one or more containers of priming solution through a portion of said fluid circuit;b. delivering a selected volume of priming solution through a source line of said fluid circuit to one or more containers of the biological fluid;c. pausing the delivery of the priming solution for a selected period of time;d. mixing said priming solution with said biological fluid in said source container(s); ande. delivering a selected volume of priming solution to a source line of said fluid circuit after said selected period of time.2. The method of further comprising delivering said selected volume of priming solution at a pre-determined rate.3. The method of comprising providing said biological fluid in a multiple source containers.4. The method of comprising delivering a priming solution to a source line communicating with each of said multiple source containers.5. The method of comprising delivering said priming solution to each of said multiple source containers.6. The method of comprising delivering different volumes of said priming solution to at least two of said source containers.7. The method of comprising delivering said priming solution before and after said pausing at different flow rates.8. The method of comprising delivering said priming solution to each of said multiple source containers simultaneously.9. The method of comprising delivering said priming solution to each of said multiple source containers sequentially.10. An automated system for the processing of biological fluid comprising:a. a reusable hardware unit comprising a separation device drive unit for ...

Method and System for Filling and Venting a Device for Extracorporeal Blood Treatment, with Stepped Flooding of a Filter

A method for filling and venting a device for extracorporeal blood treatment is disclosed, such as a patient module in a heart-lung machine, without attached patient. A filling liquid from a filling liquid container located higher than the device flows by gravity via a venous side of the system into a reservoir and flows onwards into a blood pump located at the lower end of the reservoir, wherein a first controllable valve (HC) for a venting line of a filter is opened and, after the response of an upper filling level sensor in the reservoir, is closed. An upper level of the filter is positioned higher than the upper filling level sensor, and a start-stop motion of the blood pump is performed, as a result of which a stepped flooding of the filter is made providing for an advantageous de-airing of the device. 165.-. (canceled)66. A system for extracorporeal treatment of a patient's blood , said system comprising:a control module having an automatic clamping or valving apparatus, a blood pump drive, and evaluation and control electronics; anda patient module having a blood circuit which comprises a venous blood inflow conduit, a reservoir, an oxygenator, a bubble detector, an arterial blood outflow conduit, and a blood pump;wherein the patient module engages the control module such that the blood pump drive, evaluation electronics and control electronics of the control module are operatively connected to corresponding components of the patient module; andwherein the evaluation and control electronics include a control unit that is adapted to automatically control components of the patient module to automatically perform a filling and venting process wherein the blood circuit is filled with filling fluid and air is removed from the blood circuit, without requiring human intervention after the system has been connected to a source of filling fluid and after initialization of said filling and venting process.67. A system according to wherein the blood circuit further ...

System and Method for Collecting Plasma

A method for collecting plasma includes determining the weight, height, and hematocrit of a donor, and calculating a donor plasma volume and a target plasma collection volume. The target plasma collection volume is based on the donor plasma volume and a target percentage of plasma. The method then withdraws blood from the donor through a line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate the volume of pure plasma collected within the plasma collection container, and continue processing/collecting until the calculated volume of pure plasma equals the target plasma collection volume. 1. A method for collecting plasma comprising:(a) determining a weight and height of a donor;(b) determining a hematocrit of the donor;(c) calculating a donor plasma volume based, at least in part, on the weight and height of the donor and the hematocrit of the donor;(d) calculating a target plasma collection volume based, at least in part, on the calculated donor plasma volume and a target percentage of plasma;(e) withdrawing whole blood from the donor through the venous-access device and a first line, the first line connected to a blood component separation device;(f) introducing anticoagulant into the withdrawn whole blood through an anticoagulant line;(g) separating the withdrawn whole blood into a plasma component and at least a second blood component using the blood component separation device;(h) collecting the plasma component from the blood component separation device and into a plasma collection container;(i) calculating a volume of pure plasma collected within the plasma collection container; and(j) continuing steps (e) through (i) until the calculated volume of ...

Vial Spiking Assemblies and Related Methods

This disclosure relates to vial spiking assemblies and related methods. In certain aspects, the vial spiking assemblies include a vial adapter having a base, a spike extending from a central region of the base, and a sidewall extending from the base and surrounding the spike. The base and the sidewalls partially, define a cavity that is configured to receive at least a portion of the vial. The assemblies also include a spike cover that is removably attached to the spike and that includes a material configured to indicate when the material is contacted with liquid. 1. A method comprising:connecting a drug delivery line of a dialysis system to a blood line set of the dialysis system before priming fluid flows through the drug delivery line;causing a priming fluid to flow through the drug delivery line of the dialysis system until the priming fluid contacts a material of a vial adapter assembly causing the material to indicate contact of the priming fluid with the vial adapter assembly; andstopping the flow of priming fluid through the drug delivery line after the material indicates contact of the priming fluid with the vial adapter assembly.2. The method of claim 1 , wherein the drug delivery line is connected to a vial adapter assembly comprising a vial adapter having a spike extending from a central region of a base claim 1 , and a spike cover that can be removably attached to the spike.3. The method of claim 2 , wherein the spike cover comprises the material.4. The method of claim 3 , wherein the spike cover comprises a housing defining a cavity in which the material is disposed.5. The method of claim 4 , wherein the material is visible through the housing.6. The method of claim 2 , wherein the material comprises a color changing material that changes color upon contact with a liquid.7. The method of claim 2 , wherein the material is a microporous material impregnated with at least one of the following: bromophenol blue claim 2 , cobalt chloride claim 2 , a food ...

MODULAR FLUID THERAPY SYSTEM HAVING JUMPERED FLOW PATHS AND SYSTEMS AND METHODS FOR CLEANING AND DISINFECTION

Systems and methods for cleaning and disinfecting a medical therapy device that delivers any one of hemodialysis, hemodiafiltration and hemofiltration. The system has a base module that has at least one segment of a controlled compliant flow path and at least one pair of jumpered ports configured on the base module. One or more components have connections connectable to the jumpered ports of the base module to provide for fluid communication between the segment of the controlled compliant flow path in the base module and a flow path defined by the one or more components. The base module is connected to the one or more components that define a flow path configurable for carrying out in part at least one function performed during any one of hemodialysis, hemodiafiltration or hemofiltration. 168- (canceled)69. A system , comprising:a base module having at least one segment of a flow path and at least one pair of jumpered ports configured on the base module alternatively connectable to a cleaning manifold and therapy cassette, the therapy cassette containing at least one conduit and any one or more of concentrates, cartridges, sensors elements, reservoirs, filters, and vents, the cleaning manifold and therapy cassette connectable to the jumpered ports of the base module and defining a flow path carrying out in part at least one function performed during any one of hemodialysis, hemodiafiltration, or hemofiltration;said cleaning manifold and therapy cassette having connections connectable to the jumpered ports of the base module to provide for fluid communication between the segment of the flow path in the base module and a flow path defined by the cleaning manifold or therapy cassette wherein the cleaning manifold and therapy cassette are detachable from the segment of the flow path; andwherein the base module connected to the cleaning manifold or therapy cassette defines a flow path configurable for carrying out in part at least one function performed during any one of ...

SYSTEM AND METHOD FOR COLLECTING PLASMA

A method for collecting plasma includes determining the weight, height, and hematocrit of a donor, and calculating a donor plasma volume and a target plasma collection volume. The target plasma collection volume is based on the donor plasma volume and a target percentage of plasma. The method then withdraws blood from the donor through a line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate the volume of pure plasma collected within the plasma collection container, and continue processing/collecting until the calculated volume of pure plasma equals the target plasma collection volume. 1. A method for collecting plasma comprising:(a) determining the weight and height of a donor;(b) determining the hematocrit of the donor;(c) calculating a donor plasma volume based, at least in part, on the weight and height of the donor and the hematocrit of the donor;(d) calculating a target plasma volume to collect based, at least in part, on the calculated donor plasma volume and a target percentage of plasma;(e) withdrawing whole blood from the donor through a venous-access device and a first line, the first line connected to a blood component separation device;(f) introducing anticoagulant into the withdrawn whole blood through an anticoagulant line;(g) separating the withdrawn whole blood into a plasma component and at least a second blood component;(h) collecting the plasma component from the blood component separation device and into a plasma collection container;(i) continuing steps (e) through (h) until the target plasma volume to collect is reached in the plasma collection container.2. A method according to claim 1 , further comprising:calculating a volume of ...

DIALYSIS MACHINE

The present invention relates to a dialysis machine having an extracorporeal circuit in which a dialyzer is located which has a chamber on the blood side which is flowed through by blood and a first pressure sensor, which is located upstream of the chamber on the blood side in the direction of flow of the blood, for determining a first pressure value and a second pressure sensor, which is located downstream of the chamber on the blood side in the direction of flow of the blood, for determining a second pressure value, wherein the dialysis machine has first means for determining the pressure difference between the second pressure value and the first pressure value, second means for determining the dynamic viscosity of the blood on the basis of the determined pressure difference, of the blood flow rate through the chamber on the blood side and of one or more characteristic properties of the dialyzer and third means for determining the hematocrit or the hemoglobin value of the blood on the basis of the determined viscosity, and wherein the dialysis machine has a control or regulation unit which is configured such that it sets the blood flow rate and/or the dilution rate and/or the ultrafiltration rate such that the time change of the hematocrit and/or of the hemoglobin value does not exceed a limit value or lies in a desired value range. 1. A dialysis machine having an extracorporeal circuit in which a dialyzer is located which has a chamber on the blood side which is flowed through by blood and a first pressure sensor , which is located upstream of the chamber on the blood side in the direction of flow of the blood , for determining a first pressure value and a second pressure sensor , which is located downstream of the chamber on the blood side in the direction of flow of the blood , for determining a second pressure value ,characterized in thatthe dialysis machine has first means for determining the pressure difference between the second pressure value and the first ...

Blood purification column

A blood purification column includes an adsorbent and a casing whose two ends are open ends, wherein the adsorbent is housed inside the casing, and wherein one of two casing ends is a blood inflow-side end portion and another is a blood outflow-side end portion, and wherein a filter is disposed at the blood inflow-side end portion and/or the blood outflow-side end portion of the casing, and wherein the filter satisfies (1)-(3): (1) an opening rate thereof is greater than or equal to 5% and less than or equal to 80%; (2) an equivalent diameter of an aperture thereof is greater than or equal to 1 μm and less than or equal to 5000 μm; (3) a ratio of the equivalent diameter of the aperture thereof to an average circle equivalent diameter of void spaces of the adsorbent is greater than or equal to 45%.

Cartridges and systems for outside-in flow in membrane-based therapies

Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration. These various features may enable long-term application to all dialysis and ultrafiltration related therapies, and also to other therapies and to applications including implantables, portables and wearables.

HEMODIALYSIS SYSTEM

A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly. 152.-. (canceled)53. A blood circuit assembly engagement device for a dialysis unit , comprising:an actuator movably mounted to a panel of the dialysis unit adjacent a plurality of control ports that are configured to connect with mating control ports on a back side of a blood circuit assembly, the actuator movable between a retention position and an ejection position;a retainer element coupled to the actuator and arranged, with the actuator in the retention position, to contact a portion of a front side of the blood circuit assembly, and retain the blood circuit assembly on the panel of the dialysis unit, and arranged, with the actuator in the ejection position, to release the blood circuit assembly for removal from the panel of the dialysis unit; andan ejector element coupled to the actuator or to the panel and arranged, with the actuator moved from the retention position to the ejection position, to contact a portion of the back side of the blood circuit assembly to urge the blood circuit assembly away from the panel.54. The blood circuit assembly engagement device of claim 53 , wherein ...

BLOOD TREATMENT SYSTEMS AND METHODS

Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands 125.-. (canceled)26. A hemodialysis system that includes a dialysate mixing circuit and connection ports , the system comprising:a first port fluidly connected to a first pump in the dialysate mixing circuit, the first port configured to connect to a bicarbonate charge line, the bicarbonate charge line arranged to convey fluid from the first pump to an inlet of a bicarbonate source;a second port fluidly connected to a second pump in the dialysate mixing circuit, the second port configured to connect to a bicarbonate return line, the bicarbonate return line arranged to convey a bicarbonate solution from an outlet of the bicarbonate source to the second pump;a third port fluidly connected to a third pump in the dialysate mixing circuit, the third port configured to connect to an acid flow line, the acid flow line arranged to convey an acid solution from an acid source to the third pump; anda bypass connector comprising three fluid prongs configured to connect with the first, the second, and the third ports, wherein channels in each of the three fluid prongs of the bypass connector terminate within a common chamber within the bypass connector, so that the bicarbonate charge line leading to the first pump, the bicarbonate return line ...

BLOOD TREATMENT SYSTEMS AND METHODS

Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands. 125.-. (canceled)26. A system for delivering an anticoagulant solution in a blood circuit of a hemodialysis apparatus comprising:a blood pump cassette comprising an anticoagulant metering pump, first and second diaphragm pumps, and a plurality of valves, the blood pump cassette configured for pumping blood from a cassette inlet connected to an arterial line to a cassette outlet connected to a venous line;a controller configured to control the metering pump, the first diaphragm pump and the plurality of valves to pump a bolus of the anticoagulant solution from a container connected to the blood pump cassette to a pumping chamber of the first diaphragm pump;the controller configured to control the first diaphragm pump to draw a first volume of dialysate solution into the pumping chamber before delivering the bolus of the anticoagulant solution and the first volume of dialysate solution to the blood pump cassette inlet or outlet; andthe controller configured to control the first diaphragm pump to draw a second volume of dialysate solution into the pumping chamber after delivering the bolus of anticoagulant solution and the first volume of dialysate solution, and to deliver the second volume of dialysate solution to the blood pump ...

Automatic Priming and Scheduling for Dialysis Systems

A method including automatically performing at least one integrity test on a dialysis machine after powering on the dialysis machine, wherein the at least one integrity test is selected from the group consisting of a battery test, a dialysate conductivity test, and a dialysate temperature test. The method also includes presenting, on a display of the dialysis machine, a first set of instructions for priming the dialysis machine after completing the at least one integrity test. 1. A method comprising:automatically performing at least one integrity test on a dialysis machine after powering on the dialysis machine, wherein the at least one integrity test is selected from the group consisting of a battery test, a dialysate conductivity test, and a dialysate temperature test; andpresenting, on a display of the dialysis machine, a first set of instructions for priming the dialysis machine after completing the at least one integrity test.2. The method of claim 1 , comprising presenting claim 1 , on the display claim 1 , an instruction comprising flowing claim 1 , using gravity claim 1 , priming fluid from a fluid source through an arterial blood line set.3. The method of claim 2 , comprising presenting claim 2 , on the display claim 2 , an instruction comprising closing an end of the arterial blood line set and pumping the priming fluid through a dialyzer to prime the dialyzer.4. The method of claim 2 , comprising presenting claim 2 , on the display claim 2 , an instruction comprising priming a dialysate side of a dialyzer of the dialysis machine prior to priming the arterial blood line set.5. The method of claim 1 , comprising presenting claim 1 , on the display of the dialysis machine claim 1 , a second set of instructions for priming the dialysis machine upon completion of the first set of instructions.6. The method of claim 5 , wherein completion of the first set of instructions comprises running a predetermined volume of fluid through a blood pump.7. The method of ...

BLOOD RINSEBACK SYSTEM AND METHOD

A hemodialysis system includes a dialyzer; a dialysis fluid circuit including a fresh dialysis fluid pump, and a used dialysis fluid pump; a blood circuit including a blood pump operable with an arterial line upstream of the dialyzer, a medical fluid source in fluid communication with the arterial line between a patient end of the arterial line and the blood pump, a drip chamber located along a venous line; a blood rinseback sequence wherein blood is transferred to the patient by the medical fluid, wherein the medical fluid is introduced from its source into the arterial line between an arterial line patient end and the blood pump, and flowed through the dialyzer, through the venous drip chamber along the venous line; and a blood circuit priming sequence initiated in the blood circuit via the arterial line. 1: A hemodialysis system comprising:a dialyzer; a fresh dialysis fluid pump,', 'a used dialysis fluid pump,', 'a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and', 'a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;, 'a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including'} an arterial line for removing blood from a patient and delivering the blood to the dialyzer,', 'a venous line for returning blood from the dialyzer to the patient,', 'a blood pump operable with the arterial line upstream of the dialyzer,', 'a medical fluid source in fluid communication with the arterial line between a patient end of the arterial line and the blood pump, and', 'a drip chamber located along the venous line;, 'a blood circuit in fluid communication with the dialyzer and ...

METHOD AND DEVICE FOR PURIFYING A MEMBRANE APPARATUS

'a dialysis system and a method for automatically priming a dialyzer'

A dialysis system and a method for automatically priming a dialyzer(6) are provided. The priming of the dialyzer is accomplished in two steps; namely, the use of a blood pum (21) to prime a dialyser followed by the use of the blood pump and a dialysate pump to prime the dialyser. The dialysis system filters a fluid through an extracorporeal circuit(3),a balanced flow loop (4) and a dialysate loop which is connected to the dialyser. The dialysis system and method may prevent air or air bubbles from entering the blood stream of a patient during dialysis. Moreover, the dialysis system may be, for example, a hemodialysis or peritoneal dialysis system.

Method and apparatus for calibrating plural pump fluid flow system

A blood constituent processing system uses a disposable plastic fluid flow path into which an anticoagulant must be accurately metered with respect to pumped blood flow. In a preliminary calibration phase, a closed fluid flow path is provided between the anticoagulant pump and the blood pump. One of the pumps is then controlled to inject fluid into such closed path while the other pump is controlled to withdraw fluid from that path at what is nominally an equal fluid flow rate. Changes in fluid pressure within the closed fluid flow path are then monitored and the flow rate of at least one of the pumps is changed as necessary to achieve an approximately constant fluid pressure within the closed fluid flow path. The relative pump flow control required to achieve constant pressure may then be taken as a relative flow rate calibration between the two pumps so as to permit subsequent accurate pumped metering of anticoagulant into the pumped blood flow. A similar arrangement may be used to derive relative flow calibration constants for the blood pump and a packed cell pump also present in the blood constituent processing system.

Integrated cassette for controlling fluid having an integral filter

An apparatus controls movement of fluids during an extracorporeal blood treatment session. A hollow cassette enclosure has a plurality of fluid input ports for receiving fluids into the enclosure and a plurality of fluid output ports for expelling fluids from the enclosure. Internal fluid passageways disposed within the hollow enclosure are provided for coupling together the fluid input ports, and the fluid output ports. At least one internal valve is disposed within the hollow enclosure for controlling movement of the fluid within the hollow enclosure. A filter is integrated into the cassette to filter the blood passing therethrough.