SYSTEM AND METHOD FOR PLASMA PURIFICATION PRIOR TO MONONUCLEAR CELL COLLECTION

A method of collecting mononuclear cells, comprising separating whole blood into plasma and cellular components, combining the cellular components with plasma replacement fluid to form a first mixture, and separating the first mixture into mononuclear cells and at least one component.

Method and apparatus to verify correct replacement fluid in a therapeutic exchange procedure

A method and apparatus are provided for automatically detecting the type of replacement fluid loaded by the operator during a therapeutic exchange procedure and to provide a warning alarm if an incorrect fluid is used. After the operator connects the container of replacement fluid to the replacement fluid line of a single-use kit and enters into the controller an identification of the exchange procedure to be performed, the replacement fluid is flowed through a segment of the kit in proximity to a sensor associated with the hardware component that detects the type of fluid flowing through the segment. The controller verifies whether the replacement fluid detected in the segment corresponds to that appropriate for the selected exchange procedure, and notifies the operator in the event that an incorrect replacement fluid has been loaded.

Systems and methods for controlling plasma flow rates for therapeutic exchange procedures

Systems and methods are provided for improving the flow rate of plasma being removed from a blood separation chamber during a blood separation procedure. The system includes a blood separation chamber in which plasma is separated from cellular blood components and an outlet line for removing the separated plasma from the blood separation chamber. A primary optical sensor assembly is associated with the blood separation chamber to directly monitor the interior of the blood separation chamber. A secondary optical sensor assembly is associated with the outlet line to monitor the separated plasma in the outlet line, with each optical sensor assembly checking for the presence of cellular components in the separated plasma. If the primary optical sensor assembly detects such a condition while the secondary optical sensor assembly does not, then a controller may take steps to resolve the conflict and continue the procedure.

Performing an apheresis procedure on a human subject with identity input data

Systems and methods are provided for performing a medical procedure with respect to a subject. A data storage location of the system is pre-programmed with a plurality of subject data entries, each having subject-specific information associated with it. A user interface receives an identity input from a subject, which corresponds to the identity of the subject. A controller is associated with the database and the user interface, and is programmed to compare the identity input to the subject data entries. If the identity input corresponds to the subject-specific information of a subject data entry, the controller commands a treatment device to perform a medical procedure with respect to the subject. Otherwise, if the identity input does not correspond to the subject-specific information of any of the subject data entries, the controller generates an error signal which prevents the performance of the medical procedure with respect to the subject.

Methods for extracting platelet-rich plasma for therapeutic injection

Methods are provided for collecting platelet-rich plasma. A disposable flow circuit is mounted to a fluid processing device having a fluid separation chamber and an injection device. A fluid containing plasma and platelets is continuously conveyed from a fluid source into the fluid separation chamber and processed to produce platelet-rich plasma. At least a portion of the platelet-rich plasma is automatically conveyed from the fluid separation chamber into the injection device, which is directly connected to a pump device such that at least a portion of the platelet-rich plasma from the fluid separation chamber is automatically conveyed into the pump device prior to being conveyed into the injection device. The injection device with the platelet-rich plasma is then detached from the disposable flow circuit.

SYSTEMS AND METHODS FOR ACHIEVING TARGET POST-PROCEDURE FRACTION OF CELLS REMAINING, HEMATOCRIT, AND BLOOD VOLUME DURING A THERAPEUTIC RED BLOOD CELL EXCHANGE PROCEDURE WITH OPTIONAL ISOVOLEMIC HEMODILUTION

Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator. 1. A blood processing system comprising:a blood separation device for separating whole blood into a red blood cell component and a plasma component;{'sub': WB', 'T, 'an inlet flowpath including a pump operable at a prescribed flow rate Qto convey whole blood from a patient having a whole blood volume V, a whole blood hematocrit value Hinto the separation device;'}a return flowpath to convey fluid to the patient;{'sub': 'P', 'a first outlet flowpath including a pump operable at a prescribed flow rate Qto convey separated plasma from the separation device;'}a second outlet flowpath to convey separated red blood cells from the separator;{'sub': 'T1', 'a first source of replacement fluid comprising red blood cells having a hematocrit Hin fluid communication with the return flowpath;'}{'sub': 'RF', 'a third flowpath including a pump operable at a prescribed flow rate Qto convey replacement red blood cells to the patient; and'}{'sub': WB', 'P', 'RF, 'a controller including a first stage configured to accept or derive input values relating to the patient condition and clinical objectives; a second stage configured to derive operating values for the for Q, Q, and Qsuch that the clinical objective are ...

SYSTEM AND METHOD FOR ADJUSTMENT OF BLOOD SEPARATION PROCEDURE PARAMETERS

Systems and methods are provided for automatically adjusting the operational parameters of a blood separation procedure. A blood separation device has an inlet for passing fluid thereinto and an outlet for removing fluid therefrom. A pump system is provided for moving fluid into and out of the device. In use, blood is conveyed into the device, where platelets are separated from at least a portion of the blood. A controller determines the amount of platelets in the device. Based at least in part on the amount of platelets in the device, corrective action is taken to avoid platelet aggregation in the device. The corrective action may be conveying an elevated amount of anticoagulant into the blood and/or the device and may be initiated when the determined amount of platelets approaches, meets, or exceeds a threshold predicted likelihood of platelet aggregation. 1. A blood processing method comprising:conveying blood into a blood separation device;determining the amount of platelets in the blood and/or in the blood separation device;predicting the likelihood of platelet aggregation in the blood separation device based at least in part on the determined amount of platelets; andadjusting an operational parameter if the predicted likelihood of platelet aggregation in the blood separation device approaches, meets, or exceeds a predetermined value.2. The method of claim 1 , wherein said adjusting an operational parameter includes conveying an amount of anticoagulant into the blood and/or the blood separation device.3. The method of claim 1 , further comprising continuously adding anticoagulant to the blood at an anticoagulant flow rate claim 1 , wherein said adjusting an operational parameter includes adding anticoagulant to the blood at a different anticoagulant flow rate.4. The method of claim 1 , further comprising continuously adding anticoagulant to the blood at an anticoagulant flow rate claim 1 , wherein said adjusting an operational parameter includes adding ...

CONTROL OF INTERFACE BETWEEN SEPARATED BLOOD COMPONENTS UNDER LIPEMIC AND HEMOLYTIC CONDITIONS

Blood separation systems and methods are provided for controlling the interface between separated blood components. The system includes a blood separation chamber configured to separate blood into first and second blood components and an outlet line for removing at least a portion of the first blood component from the blood separation chamber. A primary optical sensor assembly is associated with the blood separation chamber to directly monitor the interior of the blood separation chamber. A secondary optical sensor assembly is associated with the outlet line to monitor the first blood component in the outlet line. The system also includes a controller programmed to select between the primary optical sensor assembly and the secondary optical sensor assembly for monitoring contamination of the first blood component. The system is particularly advantageous for preventing contamination of separated plasma which is lipemic or hemolytic. 1. A blood separation system , comprising:a blood separation chamber configured to separate at least one blood component from blood;an outlet line associated with the blood separation chamber for removing at least a portion of said one blood component from the blood separation chamber;a first optical sensor assembly configured to directly monitor the interior of the blood separation chamber;a second optical sensor assembly configured to monitor the contents of the outlet line and produce an output; anda controller configured to select, during a blood separation procedure, the first optical sensor assembly or the second optical sensor assembly for process monitoring based at least in part on said output.2. The blood separation system of claim 1 , wherein the controller is configured to select the first optical sensor assembly or the second optical sensor assembly for detecting the presence of other blood components in the one blood component.3. The blood separation system of claim 1 , wherein the output of the second optical sensor ...

SYSTEM AND METHOD TO BETTER ASSURE CORRECT USE OF PRE-PROGRAMMED MEDICAL DEVICES

Systems and methods are provided for performing a medical procedure with respect to a subject. A data storage location of the system is pre-programmed with a plurality of subject data entries, each having subject-specific information associated with it. A user interface receives an identity input from a subject, which corresponds to the identity of the subject. A controller is associated with the database and the user interface, and is programmed to compare the identity input to the subject data entries. If the identity input corresponds to the subject-specific information of a subject data entry, the controller commands a treatment device to perform a medical procedure with respect to the subject. Otherwise, if the identity input does not correspond to the subject-specific information of any of the subject data entries, the controller generates an error signal which prevents the performance of the medical procedure with respect to the subject. 1. A system for performing a medical procedure with respect to a subject , comprising:a data storage location pre-programmed with one or more subject data entries, each subject data entry having subject-specific information associated with it;a user interface adapted to receive an identity input from a subject;a treatment device; and compare the identity input to the subject-specific information of the one or more subject data entries, and', 'command the treatment device to perform a medical procedure with respect to the subject if the identity input corresponds to the subject-specific information of one of the subject data entries or, if the identity input does not correspond to the subject-specific information of any of the subject data entries, generate an error signal that prevents the performance of the medical procedure with respect to the subject., 'a controller associated with the user interface and the treatment device and configured to'}2. The system of claim 1 , wherein the controller is configured to command the ...

Systems and Methods for Achieving Target Post-Procedure Fraction of Cells Remaining, Hematocrit, and Blood Volume During a Therapeutic Red Blood Cell Exchange Procedure With Optional Isovolemic Hemodilution

Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator. 1. A blood processing system comprising:a blood separation device for separating whole blood into a red blood cell component and a plasma component;{'sub': WB', 'T, 'an inlet flowpath including a pump operable at a prescribed rate Qto convey whole blood from a patient having a whole blood volume V, a whole blood hematocrit value Hinto the separation device;'}a return flowpath to convey fluid to the patient;{'sub': 'P', 'a first outlet flowpath including a pump operable at a prescribed flow rate Qto convey separated plasma from the separation device;'}a second outlet flowpath to convey separated red blood cells from the separator;{'sub': 'T1', 'a source of replacement red blood cells having a hematocrit Hin fluid communication with the return flowpath;'}{'sub': 'RF', 'a third flowpath including a pump operable at a prescribed flow rate Qto convey replacement red blood cells to the patient; and'}{'sub': WB', 'P', 'RF, 'a controller including a first stage operable to accept or derive input values relating to the patient condition and clinical objectives; a second stage operable to derive operating values for the for Q, Q, and Qsuch that the clinical objective are achieved simultaneously at the ...

Control Of Interface Between Separated Blood Components Under Lipemic And Hemolytic Conditions

Blood separation systems and methods are provided for controlling the interface between separated blood components. The system includes a blood separation chamber configured to separate blood into first and second blood components and an outlet line for removing at least a portion of the first blood component from the blood separation chamber. A primary optical sensor assembly is associated with the blood separation chamber to directly monitor the interior of the blood separation chamber. A secondary optical sensor assembly is associated with the outlet line to monitor the first blood component in the outlet line. The system also includes a controller programmed to select between the primary optical sensor assembly and the secondary optical sensor assembly for monitoring contamination of the first blood component. The system is particularly advantageous for preventing contamination of separated plasma which is lipemic or hemolytic. 1. A blood separation system , comprising:a blood separation chamber configured to separate blood into at least one blood component and a different other blood component;an outlet line associated with the blood separation chamber for removing at least a portion of said one blood component from the blood separation chamber;a first optical sensor assembly configured to directly monitor the interior of the blood separation chamber;a second optical sensor assembly configured to monitor the contents of the outlet line and produce an output based at least in part on the light transmissivity of the contents of the outlet line; anda controller configured to select, during a blood separation procedure, only one of the first optical sensor assembly or the second optical sensor assembly for detecting the presence of said different other blood component in the one blood component, wherein the first optical sensor assembly is selected under a first condition in which the output has a first value and wherein the second optical sensor assembly is ...

Methods for Automated Blood Prime

A method is disclosed for priming a kit for use in a therapeutic apheresis procedure with previously-collected blood prior to flowing the patient's whole blood into the inlet line of the kit, as part of a procedure in which a selected blood component is separated from a patient's whole blood, and replaced with a previously-collected blood component. The operator enters into the controller of the separation device the hematocrit value of the previously-collected blood. Then, in response to prompts by the controller, the operator enters a target hematocrit value for the previously-collected blood and an identification of the portion of the kit to be primed. The identified portion of the kit is automatically primed with the previously-collected blood. The patient is then connected to the inlet line of the kit in response to a prompt from the controller and the therapeutic procedure is commenced.

Inhibitor Combination for Lithium Salt-Catalyzed Transesterification Process and Method for Removing Lithium Salt

A process to form a composition comprising an asymmetrical polyene, the asymmetrical polyene comprising an “α,β unsaturated-carbonyl end” and a “C—C double bond end,” the process comprising: reacting an alkene- or polyene-containing alcohol with an alkyl ester of an α,β unsaturated carboxylic acid in the presence of at least the following components A) through C) to form a solution comprising an asymmetrical polyene: 2. The composition of comprising from 25 ppm to less than 100 ppm claim 1 , based on the weight of the composition claim 1 , of the inhibitor selected from the group consisting of 4-HT and derivatives thereof.3. The composition of comprising from 50 ppm to less than 2000 ppm claim 1 , based on the weight of the composition claim 1 , of MeHQ.4. The composition of further comprising less than 10 wt % unreacted alkene- or polyene-containing alcohol claim 1 , based on the total weight of the composition.5. The composition of comprising from 2 wt % to less than 10 wt % unreacted alkene- or polyene-containing alcohol claim 4 , based on the total weight of the composition claim 4 , wherein the unreacted alkene- or polyene-containing alcohol is polypropylene glycol allyl ether.6. The composition of further comprising less than 10 wt % of Michael adducts claim 1 , based on the total weight of the composition.7. The composition of further comprising a lithium salt.8. The composition of claim 7 , wherein the lithium salt has the structure LiX claim 7 , wherein n is 1 or 2; and X is selected from the group consisting of hydroxide claim 7 , oxide claim 7 , halide claim 7 , carbonate claim 7 , bicarbonate claim 7 , alkoxide claim 7 , alkonate claim 7 , alkenoate claim 7 , phenoxide claim 7 , sulfate claim 7 , bisulfate claim 7 , sulfonate claim 7 , phosphate claim 7 , phosphonate claim 7 , perchlorate claim 7 , and nitrate.9. The composition of claim 7 , wherein the lithium salt has the structure LiX claim 7 , wherein n is 1 or 2; and X is selected from the group ...

SYSTEM AND METHOD FOR PLATELET REMOVAL DURING MONONUCLEAR CELL COLLECTION

A method of collecting mononuclear cells, comprising separating whole blood into cellular components and platelets suspended in plasma, separating the platelets suspended in plasma into platelet concentrate and platelet-poor plasma, combining the cellular components with the platelet-poor plasma to form a first mixture, and separating the first mixture into mononuclear cells and at least one component. 1. A method of collecting mononuclear cells , comprising:separating whole blood into cellular components and platelet-rich plasma;separating the platelet-rich plasma into platelet concentrate and platelet-poor plasma;combining the cellular components with the platelet-poor plasma to form a first mixture; andseparating the first mixture into mononuclear cells and at least one component.2. The method of claim 1 , wherein the platelet-poor plasma contains fewer platelets than does the platelet-rich plasma.3. The method of claim 1 , wherein the step of separating whole blood into cellular components and platelet-rich plasma is performed by a centrifugal separator.4. The method of claim 3 , furthering comprising the steps of:separating the whole blood within a compartment of a separation chamber;directing the cellular components and the platelet-rich plasma to separate locations until separation of the whole blood is complete;separating within the compartment the platelet-rich plasma into platelet concentrate and platelet-poor plasma;directing the first mixture into the compartment;and separating the first mixture into mononuclear cells and at least one component in the compartment.5. The method of claim 4 , wherein the steps of separating whole blood into cellular components and platelet-rich plasma and separating the first mixture into mononuclear cells and at least one component take place substantially in series.6. The method of claim 3 , further comprising the steps of:separating the whole blood within a first compartment of a separation chamber, directing the ...

PERFORMING AN APHERESIS PROCEDURE ON A HUMAN SUBJECT WITH IDENTITY INPUT DATA

A system for performing an apheresis procedure on a human subject includes an apheresis device having a communication channel in communication with a data storage device remote from the apheresis treatment device, an input device configured to receive an identity input data, wherein the identity input data comprises a combination of data, and a processing circuit. The processing circuit is configured to compare the identity input data to an identity of a human subject downloaded from the data storage device and, if the combination of data is consistent with two or more subject-specific information for a subject data entry, to provide access to an apheresis procedure operated according to the pre-programmed parameters on the apheresis device. The processing circuit is configured to derive an operating parameter for the apheresis procedure based on at least one of the subject-specific information of the human subject and to operate the apheresis procedure using the derived operating parameter. 1. A system for performing an apheresis procedure on a human subject , comprising:an apheresis treatment device configured to draw blood from a human subject, separate the blood by blood component, and return at least one of the components to the human subject; anda remote data storage device located remotely from the apheresis treatment device and configured to communicate with the apheresis treatment device over a network, the remote data storage device programmed with a plurality of subject data entries, each subject data entry associated with a human subject, each subject data entry comprising subject-specific information, the data storage device configured to download an identity of the human subject from the subject data entry and further configured to pre-program the apheresis treatment device with a plurality of parameters for the apheresis medical procedure, the parameters comprising at least one of a rate at which fluid may be drawn from the subject and a rate at which ...

SYSTEMS AND METHODS FOR MONITORING AND CONTROLLING FLUID BALANCE DURING A BIOLOGICAL FLUID PROCEDURE

Described is a method for controlling fluid volume balance. A controller is configured with a first set of inputs comprising a hematocrit, a total blood volume, and an ACD ratio. A maximum extracorporeal RBC amount during the procedure is estimated based on the first set of inputs. A fluid circuit is primed with a priming fluid. Whole blood is drawn from a blood source and separated into a RBC component, a target cell component, and a plasma component. The target cell component is directed to a product container. The product container comprising the target cell component is treated. A treated target cell component, a portion of the RBC component remaining in the fluid circuit, and/or a portion of the plasma component remaining in the fluid circuit are returned to the blood source. A first response action is provided if the maximum extracorporeal RBC amount estimated is above a programmed limit. 1. A system for monitoring and controlling fluid balance during an extracorporeal photopheresis procedure , comprising:a disposable fluid circuit comprising a product container configured to receive a target cell component;a separator configured to work in association with the disposable fluid circuit, the separator comprising a chamber configured to rotate about a rotational axis and convey whole blood from a blood source into an inlet region of the chamber for separation into a red blood cell component, a plasma component, and the target cell component; estimate an end-of-procedure fluid balance by calculating a total volume of anticoagulant solution having a citrate concentration to be used for the procedure, wherein the end-of-procedure fluid balance is estimated based on manual or automatic inputs comprising an ACD ratio relating unanticoagulated extracorporeal whole blood to anticoagulant solution, an amount of whole blood to process, a citrate infusion threshold rate, a patient body weight associated with the blood source, and a total blood volume of the blood source ...

Systems And Methods For Collecting Mononuclear Cells

Fluid processing assemblies and methods are provided for mononuclear cell collection. Mononuclear cells are separated from red blood cells in a blood separation chamber, with the mononuclear cells and then the red blood cells exiting the chamber via an outlet port. The mononuclear cells and then the red blood cells enter an outlet flow path that is in fluid communication with a mononuclear cell collection container. The outlet flow path includes a visual indicium, which an operator may use to determine the position of the red blood cells within the outlet flow path and when to end mononuclear cell collection by preventing fluid communication between the outlet flow path and the mononuclear cell collection container. 126-. (canceled)27. A fluid processing assembly configured for use in combination with a fluid processing system for separating mononuclear cells from red blood cells , comprising:a blood separation chamber configured to separate mononuclear cells from red blood cells and including an outlet port configured to accommodate the flow of mononuclear cells and then red blood cells exiting the blood separation chamber;a mononuclear cell collection container; andan outlet flow path extending between the outlet port and the mononuclear cell collection container, wherein the outlet flow path includes a visual indicium upstream of the mononuclear cell collection container positioned to indicate that fluid communication between the outlet flow path and the mononuclear cell collection container is to be prevented upon red blood cells flowing through the outlet flow path reaching a location identified by the visual indicium.28. The fluid processing assembly of claim 27 , wherein the outlet flow path is defined bya rigid cassette,an upstream flexible tubing extending between the outlet port and the cassette, anda downstream flexible tubing extending between the cassette and the mononuclear cell collection container, with the visual indicium identifying a location ...

Performing an apheresis procedure on a human subject with identity confirmation

A system for performing an apheresis procedure on a human subject includes an apheresis treatment device and a remote data storage device. The remote data storage device communicates with the apheresis treatment device over a network. The remote data storage device is programmed with a plurality of subject data entries, each subject data entry comprising subject-specific information. The remote data storage device downloads subject-specific information comprising a name and a birth date from the subject data entry and programs the apheresis treatment device with a plurality of parameters for the apheresis medical procedure. The apheresis treatment device includes a touch screen and a controller, the controller confirming an identity of the human subject based on an input. Based on the result of the confirmation access is provided to an apheresis procedure operated according to the programmed parameters on the apheresis treatment device.

Method and apparatus to verify correct replacement fluid in a therapeutic exchange procedure

A method and apparatus are provided for automatically detecting the type of replacement fluid loaded by the operator during a therapeutic exchange procedure and to provide a warning alarm if an incorrect fluid is used. After the operator connects the container of replacement fluid to the replacement fluid line of a single-use kit and enters into the controller an identification of the exchange procedure to be performed, the replacement fluid is flowed through a segment of the kit in proximity to a sensor associated with the hardware component that detects the type of fluid flowing through the segment. The controller verifies whether the replacement fluid detected in the segment corresponds to that appropriate for the selected exchange procedure, and notifies the operator in the event that an incorrect replacement fluid has been loaded.

PLASMA FLOW RATES FOR THERAPEUTIC EXCHANGE PROCEDURES

Systems and methods are provided for improving the flow rate of plasma being removed from a blood separation chamber during a blood separation procedure. The system includes a blood separation chamber in which plasma is separated from cellular blood components and an outlet line for removing the separated plasma from the blood separation chamber. A primary optical sensor assembly is associated with the blood separation chamber to directly monitor the interior of the blood separation chamber. A secondary optical sensor assembly is associated with the outlet line to monitor the separated plasma in the outlet line, with each optical sensor assembly checking for the presence of cellular components in the separated plasma. If the primary optical sensor assembly detects such a condition while the secondary optical sensor assembly does not, then a controller may take steps to resolve the conflict and continue the procedure. 1. A blood separation system , comprising:a blood separation chamber configured to separate at least one cellular component from plasma;an outlet line associated with the blood separation chamber for removing at least a portion of the plasma from the blood separation chamber;a first optical sensor assembly configured to directly monitor the interior of the blood separation chamber and generate an output upon detecting a condition indicative of the presence of said at least one cellular component in the outlet line;a second optical sensor assembly configured to monitor the contents of the outlet line for the presence of said at least one cellular component in the outlet line; anda controller programmed to receive said output from the first optical sensor and initiate a countermeasure to prevent an additional amount of said at least one cellular component from entering the outlet line and/or remove said at least one cellular component from the outlet line, wherein the controller is further programmed to recognize a conflict between the first and second ...

Methods and Systems for Collecting Samples in a Photopheresis Procedure

Methods and systems for sampling blood components in a photopheresis procedure are disclosed. The methods include collecting samples at selected times during a photopheresis procedure. 1. A method for collecting blood samples in a photopheresis procedure comprising;a) programming a photopheresis system for pausing a photopheresis procedure to allow for the collection of blood sample at selected time intervals;b) collecting a first sample of a blood component to be treated by radiation at a time prior to irradiation of said blood component;c) continuing with said photopheresis procedure; andd) collecting a sample of a blood component that has been treated by radiation.2. The method of further comprising collecting a sample of a blood component to be treated by radiation at a time prior to irradiation of said blood component but after addition of a photochemical agent.3. The method of comprising pausing the photopheresis procedure at the time of collecting the first sample.4. The method of comprising pausing the photopheresis procedure at the time of collecting the sample that has been treated by radiation.5. The method of comprising collecting samples of blood component that is to be treated and has been treated in an treatment container.6. The method of wherein said irradiation container includes a plurality of sampling sites integrally joined to said treatment container.7. The method of comprising sealing and removing one or more sample pouches from said sample sites in a sterile manner.8. The method of wherein a sample site for collecting a sample of an irradiated blood component is integrally joined to said treatment container and is spaced from said container by a tube defining a flow path.9. The method of comprising flushing said flow path to deliver said treated blood component to said sampling site for collecting a sample of an irradiated blood component.10. The method of comprising determining the amount of said blood component in said treatment container.11 ...

System And Method For Plasma Purification Prior To Mononuclear Cell Collection

A method of collecting mononuclear cells includes separating whole blood into plasma and cellular components, purifying the plasma through a plasma adsorption column to create purified plasma, combining the cellular components with the purified plasma to form a first mixture, and separating the first mixture into mononuclear cells and at least one component. Alternatively, whole blood may be flowed through an adsorption column to create purified whole blood, with the purified whole blood then being separated into mononuclear cells and at least one component. 111-. (canceled)12. A method of collecting mononuclear cells , comprising:separating whole blood into plasma and cellular components;purifying the plasma through a plasma adsorption column to create purified plasma;combining the cellular components with the purified plasma to form a first mixture; andseparating the first mixture into mononuclear cells and at least one component.13. The method of claim 12 , further comprising the step of performing extracorporeal photopheresis on the mononuclear cells claim 12 , and wherein the purified plasma contains fewer proteins claim 12 , lipids claim 12 , and/or bilirubin than does the plasma.14. The method of claim 12 , wherein the step of separating whole blood into plasma and cellular components is performed by a centrifugal separator.15. The method of claim 12 , wherein step of separating whole blood into plasma and cellular components is performed by a spinning membrane separator.16. The method of claim 12 , wherein the mononuclear cells comprise at least one of lymphocytes claim 12 , monocytes claim 12 , and stem cells.17. A method of collecting mononuclear cells claim 12 , comprising:providing an adsorption column through which whole blood is flowed to create purified whole blood; andseparating the purified whole blood into mononuclear cells and at least one component.18. The method of claim 17 , wherein the purified whole blood is separated by a centrifugal ...

Convertible Fluid Processing Assemblies

Mid-procedure termination of a mononuclear cell collection procedure may prevent collection of an amount of red blood cells that is required to harvest a complete mononuclear cell product. Blood separation systems and methods are provided for minimizing the impact of or recovering from mid-procedure termination of such a mononuclear cell collection procedure. According to one approach, blood or separated red blood cells are conveyed into a red blood cell collection container relatively early in the procedure to minimize the impact of a later termination of the procedure. According to another approach, blood and/or separated red blood cells within a fluid processing assembly are redirected through the fluid processing assembly following mid-procedure termination to allow for at least partial mononuclear cell collection. According to yet another approach, a double-needle fluid processing assembly may be converted into a single-needle configuration to allow for continued processing following mid-procedure termination. 120-. (canceled)21. A fluid processing assembly configured for use in combination with a fluid processing system , comprising:a separation chamber configured to separate a fluid into two or more fluid components and including an inlet flow path and an outlet flow path;a draw line in fluid communication with the inlet flow path and configured for direct connection to a source to draw a fluid from the source into the fluid processing assembly; and the draw line includes a first connector,', 'the return line includes a second connector configured to be connected to the first connector, and', 'connecting the first and second connectors removes one of the draw and return lines from direct connection to the source while placing the other one of the draw and return lines into condition for drawing fluid from the source into the fluid processing assembly and conveying a replacement fluid and/or at least a portion of a separated fluid component to the source., 'a ...

SYSTEMS AND METHODS FOR USE AND CONTROL OF AN AUTOMATED SEPARATOR WITH ADSORPTION COLUMNS

Blood treatment systems and methods are provided for combining a blood separation system and an adsorption device. The blood separation system is configured to separate a blood component from blood, while the adsorption device is configured to receive at least a portion of the separated blood component and process it. The blood separation system includes a fluid flow element and a controller. The fluid flow element is configured for flowing the separated blood component into the adsorption device. The controller controls the fluid flow element based at least in part on one or more processing parameters. The processing parameters include a maximum flow rate of the separated blood component flowed into the adsorption device, a maximum pressure of the separated blood component flowed into the adsorption device, and/or the volume of fluid in a location of the system. 1. A blood treatment system comprising , in combination:a blood separation system configured to separate a blood component from blood; and a fluid flow element configured for flowing said at least one blood component into the adsorption device, and', 'a controller which controls the fluid flow element based at least in part on one or more processing parameters including a maximum flow rate of said at least a portion of said blood component flowed into the adsorption device and/or a maximum pressure of said at least a portion of said blood component flowed into the adsorption device., 'an adsorption device configured to receive at least a portion of said blood component from the blood separation system and process said at least a portion of said blood component, wherein the blood separation system includes'}2. A blood treatment system comprising , in combination:a blood separation system configured to separate a blood component from blood; and each of the blood separation system and the adsorption device includes a fluid flow element, with the fluid flow element of the blood separation system being ...

Method for the Preparation of N-Oxyl Hindered Amine Inhibitors

The present disclosure provides a composition and method for the preparation of N-oxyl hindered amine esters by contacting a compound of Formula (I), wherein Rand Rare independently an alkyl, with a compound of Formula (II), wherein Rand Rare independently an alkyl, and n is an integer from 3 to 10, in the presence of a catalyst and a solvent, wherein the catalyst comprises at least one of tin, lithium, zirconium, and hafnium. 2. The method of wherein R-Rare methyl groups and n is from 6 to 8.3. The method of further comprising the step of employing a reflux-to-distillate ratio of at least 99 to 1.4. The method of wherein the catalyst is dialkyltin oxide.5. The method of wherein the catalyst is lithium hydroxide.6. The method of wherein the catalyst is zirconium acetyl acetonate.7. The method of wherein the catalyst is hafnium acetylacetonate.9. The composition of comprising twice as many equivalents of the compound of Formula I than the compound of Formula II.10. The composition of wherein R-Rare methyl groups and n is from 6 to 8.12. (canceled) This disclosure relates to an improved method for preparing N-oxyl derivatives of hindered amine esters.The preparation of N-oxyl compounds is typically performed by oxidizing a hindered amine with a hydroperoxide in the presence of an oxide catalyst. For example, U.S. Pat. No. 5,218,116 discloses hindered amines oxidized by hydrogen peroxide and a titanium catalyst to produce N-oxyl derivatives.Russian Patent No. 1,168,556 discloses the preparation of 1-oxyl-2,2,6,6-tetramethylpiperidin-yl esters of carboxylic acids by reacting the corresponding 4-hydroxy compound with a lower alkyl ester of a carboxylic acid in the presence of a tetraalkyl orthotitanate transesterification catalyst in xylene.U.S. Pat. No. 5,574,163 discloses preparing N-oxyl hindered amine esters by reacting an N-oxyl compound in the presence of a tetraalkyl orthotitanate or a trialkoxy titanium chloride transesterification catalyst and an aliphatic ...

APPARATUS AND METHOD FOR BATCH PHOTOACTIVATION OF MONONUCLEAR CELLS WITH CRYOPRESERVATION

An apparatus and method for the batch photoactivation of mononuclear cells (MNCs) is described. The system includes a programmable controller configured to automatically separate whole blood in a first collection cycle to obtain a first quantity of MNCs; separate whole blood in a second collection cycle to obtain a second quantity of MNCs while simultaneously photoactivating the first quantity of MNCs to obtain a first quantity of treated MNCs; either store the first quantity of treated MNCs or reinfuse the first quantity of treated MNCs; photoactivate the second quantity of MNCs to obtain a second quantity of treated MNCs; either store the second quantity of treated MNCs or reinfuse the second quantity of treated MNCs; and reinfuse any blood components remaining after the second collection cycle. If the treated MNCs are to be stored, they may optionally be cryopreserved such that the treated MNCs retain their apoptotic properties after cryopreservation and subsequent thawing. 1. A method for the batch photoactivation of mononuclear cells (MNCs) comprising:a) separating whole blood in a first collection cycle to obtain a first quantity of MNCs;b) separating whole blood in a second collection cycle to obtain a second quantity of MNCs while simultaneously photoactivating the first quantity of MNCs to obtain a first quantity of treated MNCs;c) either storing the first quantity of treated MNCs or reinfusing the first quantity of treated MNCs;d) photoactivating the second quantity of MNCs to obtain a second quantity of treated MNCs;e) either storing the second quantity of treated MNCs or reinfusing the second quantity of treated MNCs;f) reinfusing any blood components remaining after the second collection cycle; andg) if either of the first or second quantity of treated MNCs is to be stored, combining said quantity of treated MNCs with a cryopreservation medium, and cryopreserving said quantity of treated MNCs to obtain a population of cryopreserved MNCs having an ...

PERFORMING AN APHERESIS PROCEDURE WITH IDENTITY CONFIRMATION

A system for performing an apheresis procedure on a human subject includes an apheresis device configured to receive over a network donor information comprising donor-specific information and to receive over the network a plurality of parameters for an apheresis procedure. The apheresis device is further configured to receive a user input from a touch screen to confirm a donor based on the donor-specific information. The apheresis device is further configured to, in response to confirming the donor, proceed with an apheresis procedure operated according to the plurality of parameters, the apheresis procedure configured to draw whole blood from a human subject, separate at least one component from the whole blood, and return at least one other component of the whole blood to the donor. 120.-. (canceled)21. A system for performing an apheresis procedure on a donor , comprising:an apheresis device; and receive donor information used to identify a donor;', 'store the donor information into a data entry of a database, the database comprising data entries for a plurality of different donors; and', 'transmit the donor information comprising a name and a birth date from the database to the apheresis device;', 'transmit a plurality of parameters to the apheresis device to program the apheresis device for an apheresis procedure; and, 'a server configured to receive an input from a touch screen of the apheresis device;', 'confirm an identity of the donor based on the input; and', 'perform the apheresis procedure according to the programmed parameters on the apheresis device based on confirming the identity of the donor., 'the apheresis device configured to22. The system of claim 21 , the apheresis device configured to generate an error signal that prevents the performance of the apheresis procedure with respect to the donor in the case where the identity of the donor is not confirmed.23. The system of claim 21 , wherein the donor information further comprises sex and weight of ...

PERFORMING AN APHERESIS PROCEDURE ON A HUMAN SUBJECT WITH IDENTITY INPUT DATA

Systems and methods are provided for performing a medical procedure with respect to a subject. A data storage location of the system is pre-programmed with a plurality of subject data entries, each having subject-specific information associated with it. A user interface receives an identity input from a subject, which corresponds to the identity of the subject. A controller is associated with the database and the user interface, and is programmed to compare the identity input to the subject data entries. If the identity input corresponds to the subject-specific information of a subject data entry, the controller commands a treatment device to perform a medical procedure with respect to the subject. Otherwise, if the identity input does not correspond to the subject-specific information of any of the subject data entries, the controller generates an error signal which prevents the performance of the medical procedure with respect to the subject. 130-. (canceled)31. A system for performing an apheresis procedure on a human subject , comprising:a data storage device programmed with a plurality of subject data entries, each subject data entry associated with a human subject, each subject data entry comprising subject-specific information, the data storage device further configured to store a parameter for the apheresis medical procedure, the parameter indicative of at least one of a rate at which fluid may be drawn from the subject and a rate at which fluid may be returned to the subject;an input device configured to receive an identity input data;an apheresis treatment device configured to draw blood from a human subject, separate the blood by blood component, and return at least one of the components to the human subject; anda processing circuit configured to compare the identity input data to the subject-specific information of the plurality of subject data entries and, based at least in part on the result of the comparison, provide access to an apheresis procedure ...

Systems And Methods For Separating Blood Under Conditions Of Reduced Plasma Clarity

Blood separation systems and methods are provided for separating blood under conditions of reduced plasma clarity. The system may assess plasma clarity by monitoring light transmissivity of plasma or comparing an actual plasma flow rate to an ideal plasma flow rate, with a low flow rate indicating decreased clarity, which may be addressed by increasing the plasma flow rate. For extracorporeal photopheresis, plasma clarity may be a factor in determining the dosage of irradiating light to apply to mononuclear cells. A fluid processing assembly for mononuclear cell collection may include visual indicium, which an operator may use to determine when to end mononuclear cell collection. The system may detect red blood cells flowing toward a mononuclear cell collection container and reverse the direction of flow to prevent red blood cells from entering the container. An operator may also be enabled to selectively begin and/or end harvesting of mononuclear cells. 1. A fluid processing system , comprising:a blood separation chamber configured to separate mononuclear cells from a plasma constituent of blood;an outlet flow path associated with the blood separation chamber for alternately removing at least a portion of said plasma constituent and at least a portion of said mononuclear cells from the blood separation chamber, wherein the outlet flow path includes a valve station movable between first and second conditions to change the direction of flow of fluid through the outlet flow path;a mononuclear cell collection container in fluid communication with the outlet flow path; and a build-up phase in which said at least a portion of said plasma constituent flows through the outlet flow path and the controller causes the valve station to be in the first condition to direct the flow of said at least a portion of said plasma constituent through the outlet flow path away from the mononuclear cell collection container while a volume of the mononuclear cells increases in the blood ...

SYSTEMS AND METHODS FOR EXTRACTING PLATELET-RICH PLASMA FOR THERAPEUTIC INJECTION

Systems and methods are provided for processing blood or a fluid containing blood plasma and platelets. The blood or fluid is continuously added into a fluid separation chamber, which is used to isolate platelet-rich plasma therein. At least a portion of the platelet-rich plasma is automatically transferred from the fluid separation chamber into an injection device, with the fluid separation chamber and the injection device comprising components of a disposable flow circuit, which may be a closed system. One or more injection devices may be connected to a collection container or a pump device of the disposable flow circuit. 1. A method for processing a fluid containing blood plasma and platelets , comprising:continuously adding a fluid containing blood plasma and platelets into a fluid separation chamber;isolating platelet-rich plasma in the fluid separation chamber; andautomatically transferring at least a portion of the platelet-rich plasma from the fluid separation chamber into an injection device.2. The method of claim 1 , wherein isolating platelet-rich plasma in the fluid separation chamber includes separating platelet-rich plasma from the fluid containing blood plasma and platelets.3. The method of claim 1 , wherein isolating platelet-rich plasma in the fluid separation chamber includesseparating platelet concentrate and platelet-poor plasma from the fluid containing blood plasma and platelets, andadding at least a portion of the platelet-poor plasma to the platelet concentrate to form platelet-rich plasma.4. The method of claim 1 , whereinthe fluid comprises blood,said continuously adding a fluid containing blood plasma and platelets into a fluid separation chamber includes drawing blood from a blood source into the fluid separation chamber prior to isolating platelet-rich plasma in the fluid separation chamber,said isolating platelet-rich plasma in the fluid separation chamber includes separating packed red blood cells from the blood, and further ...

Systems And Methods For Performing Online Extracorporeal Photopheresis

Systems and methods for performing online extracorporeal photopheresis of mononuclear cells are disclosed. During a mononuclear cell collection cycle, blood is removed from a source and separated into a plasma constituent, a mononuclear cell-containing layer, and red blood cells, followed by the collection of a pre-product including at least a portion of the mononuclear cell-containing layer and at least a portion of the separated red blood cells. The mononuclear cell collection cycle may be repeated, followed by the production of a single mononuclear cell product using the collected pre-product(s). The mononuclear cell product is irradiated using a fixed dose of light, such that the mononuclear cell product is produced so as to have a predetermined volume and a predetermined hematocrit, regardless of the number of pre-products used to produce the mononuclear cell product. Following irradiation, at least a portion of the irradiated mononuclear cell product is returned to the source. 1. An extracorporeal photopheresis system , comprising: execute a mononuclear cell collection cycle in which blood is separated into a plasma constituent, a mononuclear cell-containing layer, and red blood cells, with at least a portion of the mononuclear cell-containing layer and at least a portion of the separated red blood cells being collected together as a pre-product, and', 'produce a single mononuclear cell product from said pre-product;, 'a separation device configured to'}an irradiation device configured to irradiate the mononuclear cell product using a fixed dose of light; and allow for execution of one or more of the mononuclear cell collection cycles prior to production of the single mononuclear cell product, with the single mononuclear cell product being produced using the pre-products collected during each mononuclear cell collection cycle, and', 'control the separation device to produce the mononuclear cell product with a predetermined volume and a predetermined hematocrit ...

Inhibitor Combination for Lithium Salt-Catalyzed Transesterification Process and Method for Removing Lithium Salt

A process to form a composition comprising an asymmetrical polyene, the asymmetrical polyene comprising an “α,β unsaturated-carbonyl end” and a “C—C double bond end,” the process comprising: reacting an alkene- or polyene-containing alcohol with an alkyl ester of an α,β unsaturated carboxylic acid in the presence of at least the following components A) through C) to form a solution comprising an asymmetrical polyene: A) a lithium salt; B) a component selected from the group consisting of hydroquinone, an alkyl-substituted phenol, a substituted alkyl-substituted phenol, an alkyl-substituted hydroquinone, a substituted alkyl-substituted hydroquinone, and combinations thereof; and C) an N-oxyl-containing compound; wherein the “α,β unsaturated-carbonyl end” of the asymmetrical polyene is selected from the group consisting of structures a) through c), as described herein, and wherein the “C—C double bond end” of the asymmetrical polyene is selected from the group consisting of structures 1) through 17), as described herein. 2. The process of claim 1 , wherein the lithium salt has the structure LiX claim 1 , wherein n is 1 or 2; and X is selected from the group consisting of hydroxide claim 1 , oxide claim 1 , halide claim 1 , carbonate claim 1 , bicarbonate claim 1 , alkoxide claim 1 , alkonate claim 1 , alkenoate claim 1 , phenoxide claim 1 , sulfate claim 1 , bisulfate claim 1 , sulfonate claim 1 , phosphate claim 1 , phosphonate claim 1 , perchlorate claim 1 , nitrate claim 1 , or any other stable anionic moieties capable of forming ionic salts.3. The process of claim 1 , wherein component A) has the structure LiX claim 1 , wherein n is 1 or 2; and X is selected from the group consisting of OH claim 1 , O claim 1 , a halide claim 1 , OR claim 1 , CO claim 1 , HCO claim 1 , and R′CO; wherein R is selected from a C1-C8 straight chain or branched alkyl group or from an aryl group; wherein R′ is selected from either a C1-C8 straight chain or branched alkyl group claim 1 , ...

SYSTEM AND METHOD FOR PLATELET REMOVAL DURING MONONUCLEAR CELL COLLECTION

A method of collecting mononuclear cells, comprising separating whole blood into cellular components and platelets suspended in plasma, separating the platelets suspended in plasma into platelet concentrate and platelet-poor plasma, combining the cellular components with the platelet-poor plasma to form a first mixture, and separating the first mixture into mononuclear cells and at least one component. 115-. (canceled)16. A method of collecting mononuclear cells , comprising:separating with a separator whole blood from a whole blood source into cellular components and platelet-rich plasma;removing the cellular blood components and the platelet-rich plasma from the separator;returning the cellular components to the whole blood source without returning at least a portion of the platelets in the platelet-rich plasma to the whole blood source to reduce platelet concentration of whole blood subsequently flowing into the separator from the whole blood source;andseparating lower platelet concentration whole blood from the whole blood source into mononuclear cells and at least one component.17. The method of claim 16 , further comprising stopping the separation of whole blood from the whole blood source into cellular components and platelet-rich plasma when an optical sensor disposed downstream of the separator detects that the platelet-rich plasma removed from the separator has a target platelet concentration.18. The method of claim 16 , wherein the separator comprises a spinning membrane separator.19. The method of claim 16 , wherein the separator comprises a centrifugal separator.20. The method of claim 16 , wherein said separating whole blood into cellular components and platelet-rich plasma and said separating lower platelet concentration whole blood into mononuclear cells and at least one component are performed substantially in series.21. The method of claim 16 , wherein said separating lower platelet concentration whole blood from the whole blood source into ...

Apparatus and method for batch photoactivation of mononuclear cells

An apparatus and method for the batch photoactivation of mononuclear cells (MNCs) is described. The system includes a programmable controller configured to automatically separate whole blood in a first collection cycle to obtain a first quantity of MNCs; separate whole blood in a second collection cycle to obtain a second quantity of MNCs while simultaneously photoactivating the first quantity of MNCs to obtain a first quantity of treated MNCs; either store the first quantity of treated MNCs or reinfuse the first quantity of treated MNCs; photoactivate the second quantity of MNCs to obtain a second quantity of treated MNCs; either store the second quantity of treated MNCs or reinfuse the second quantity of treated MNCs; and reinfuse any blood components remaining after the second collection cycle.

Nontoxic catalyst for preparation of polysiloxane (meth)acrylates

A method for preparation of (meth)acrylate esters of polysiloxanes. The method comprises contacting in the presence of zirconium acetylacetonate or hafnium acetylacetonate: (i) a polysiloxane having at least two hydroxyl groups, each of which is attached to a carbon atom, and (ii) a C1-C4 alkyl (meth)acrylate.

SYSTEMS AND METHODS FOR PHOTOACTIVATION OF A BIOLOGICAL FLUID

Methods and systems for treating a biological fluid with light are disclosed. The methods and systems provide for determining a target light dose for the biological fluid; loading a treatment container holding the biological fluid into an irradiation chamber of an irradiation device comprising: with the treatment container being supported in the irradiation device in between a first array of light sources and first light energy sensors and a second light energy sensor. The first array of light sources is activated, and a first light intensity is measured with the first light energy sensors. A second light intensity is measured with the second light energy sensor, and the first light intensity is compared to the second light intensity to determine an attenuation factor. The attenuation factor is applied to the first light intensity to determine a time to achieve the target light dose, with the first array of multiple light sources being deactivated after the time to achieve the target light dose has elapsed. 1. A method for treating a biological fluid with light comprising:a) determining a target light dose for the biological fluid;b) loading a treatment container holding the biological fluid into an irradiation chamber of an irradiation device comprising: i) a first array of multiple light sources; ii) a first light energy sensor associated with each light source of the first array, the first array and first light energy sensors being disposed in the irradiation device on a first side of the irradiation chamber, and iii) a second light energy sensor disposed on a second side of the irradiation chamber; such that the treatment container is supported in the irradiation device in between the first array of multiple light sources and first light energy sensors and the second light energy sensor;c) activating the first array of multiple light sources,d) measuring a first light intensity with the first light energy sensors;e) measuring a second light intensity with the ...

Systems And Methods For Use And Control Of An Automated Separator With Adsorption Columns

Blood treatment systems and methods are provided for combining a blood separation system and an adsorption device. The blood separation system is configured to separate a blood component from blood, while the adsorption device is configured to receive at least a portion of the separated blood component and process it. The blood separation system includes a fluid flow element and a controller. The fluid flow element is configured for flowing the separated blood component into the adsorption device. The controller controls the fluid flow element based at least in part on one or more processing parameters. The processing parameters include a maximum flow rate of the separated blood component flowed into the adsorption device, a maximum pressure of the separated blood component flowed into the adsorption device, and/or the volume of fluid in a location of the system. 18-. (canceled)2. A blood treatment system comprising , in combination:a blood separation system configured to separate at least one blood component from blood; and each of the blood separation system and the adsorption device includes a fluid flow element, with the fluid flow element of the blood separation system being configured for flowing said at least one blood component to a location and the fluid flow element of the adsorption device configured for flowing said at least a portion of said at least one blood component from said location into the adsorption device, and', 'the blood separation system includes a controller which controls the fluid flow element of the blood separation system based at least in part on one or more characteristics of said location., 'an adsorption device configured to receive at least a portion of said at least one blood component from the blood separation system, wherein'}3. The blood treatment system of claim 2 , wherein the controller controls the fluid flow element of the blood separation system based at least in part on the volume of fluid in said location.4. The blood ...

SYSTEM AND METHOD FOR AUTHENTICATING DISPOSABLE COMPONENTS IN EXTRACORPOREAL PHOTOPHERESIS

A medical device verification system for an extracorporeal photopheresis procedure comprises a reusable irradiation device comprising a UV light source and a scanner. A fluid circuit comprises a disposable cell suspension container having a photo-reactive label comprising an identifiable code. The identifiable code is unobscured when the label in a first state and is obscured when the label is in a second state. The irradiation step is performed by irradiating the disposable cell suspension container for a predetermined period of time at or above the threshold UV irradiation level. A second input is received from the scanner during the irradiation step, the second input comprising identification of a state of the label. A response action is provided if the first input comprises identification of the second state of the label and/or if the second input comprises identification of the first state of the label. 1. A medical device verification system for an extracorporeal photopheresis procedure comprising:a reusable irradiation device comprising a UV light source and a scanner;a fluid circuit configured to cooperatively associate with the reusable irradiation device, the fluid circuit comprising a disposable cell suspension container having a photo-reactive label comprising an identifiable code, wherein the identifiable code is unobscured to the scanner when the label in a first state and is obscured to the scanner when the label is in a second state; and receive a first input from the scanner prior to an irradiation step, the first input comprising identification of a state of the label;', 'based on receiving the first input from the scanner identifying the first state of the label, performing the irradiation step by irradiating the disposable cell suspension container for a predetermined period of time at or above the threshold UV irradiation level;', 'receive a second input from the scanner during the irradiation step, the second input comprising identification of ...

PERFORMING AN APHERESIS PROCEDURE ON A DONOR WITH IDENTITY CONFIRMATION

A method of performing an apheresis procedure on a donor includes receiving donor information used to identify a donor and storing the donor information into a data entry of a database. The database stores data entries for a plurality of different donors. The method includes transmitting the donor information comprising a name and a birth date from the database to an apheresis treatment device. The method includes transmitting a plurality of parameters to the apheresis treatment device to program the apheresis treatment device for an apheresis procedure. The method includes receiving an input from a touch screen of the apheresis treatment device, confirming an identity of the donor based on the input, and performing the apheresis procedure according to the programmed parameters on the apheresis treatment device based on confirming the identity of the donor. 1. A method of performing an apheresis procedure on a donor , comprising:receiving donor information used to identify a donor;storing the donor information into a data entry of a database, the database comprising data entries for a plurality of different donors;transmitting the donor information comprising a name and a birth date from the database to an apheresis treatment device;transmitting a plurality of parameters to the apheresis treatment device to program the apheresis treatment device for an apheresis procedure;receiving an input from a touch screen of the apheresis treatment device;confirming an identity of the donor based on the input; andperforming the apheresis procedure according to the programmed parameters on the apheresis treatment device based on confirming the identity of the donor.2. The method of claim 1 , generating an error signal that prevents the performance of the apheresis procedure with respect to the donor in the case where the identity of the donor is not confirmed.3. The method of claim 1 , wherein the donor information further comprises sex and weight of each different donor claim 1 ...

System and method for adjustment of blood separation procedure parameters

Systems and methods are provided for automatically adjusting the operational parameters of a blood separation procedure. A blood separation device has an inlet for passing fluid thereinto and an outlet for removing fluid therefrom. A pump system is provided for moving fluid into and out of the device. In use, blood is conveyed into the device, where platelets are separated from at least a portion of the blood. A controller determines the amount of platelets in the device. Based at least in part on the amount of platelets in the device, corrective action is taken to avoid platelet aggregation in the device. The corrective action may be conveying an elevated amount of anticoagulant into the blood and/or the device and may be initiated when the determined amount of platelets approaches, meets, or exceeds a threshold predicted likelihood of platelet aggregation.

Systems and methods for performing extracorporeal photopheresis

Systems and methods are disclosed for performing online extracorporeal photopheresis in which the needs of a particular patient as to the fluid balance to be achieved and the time allotted to perform the procedure can be prioritized. Whole blood is removed from a patient and introduced through a processing set into a separation chamber to separate the desired cell population from the blood. The separated cell population is processed through the set which is associated with a treatment chamber where the cells are treated. Once treated, the cells are returned to the patient.

Systems and methods for monitoring and controlling fluid balance during a biological fluid procedure

Described is a system for controlling fluid volume balance. A controller is configured with a first set of inputs comprising a hematocrit, a total blood volume, and an ACD ratio. A maximum extracorporeal RBC amount during the procedure is estimated based on the first set of inputs. A fluid circuit is primed with a priming fluid. Whole blood is drawn from a blood source and separated into a RBC component, a target cell component, and a plasma component. The target cell component is directed to a product container. The product container comprising the target cell component is treated. A treated target cell component, a portion of the RBC component remaining in the fluid circuit, and/or a portion of the plasma component remaining in the fluid circuit are returned to the blood source. A first response action is provided if the maximum extracorporeal RBC amount estimated is above a programmed limit.

Performing an apheresis procedure with identity confirmation

A system for performing an apheresis procedure on a human subject includes an apheresis device configured to receive over a network donor information comprising donor-specific information and to receive over the network a plurality of parameters for an apheresis procedure. The apheresis device is further configured to receive a user input from a touch screen to confirm a donor based on the donor-specific information. The apheresis device is further configured to, in response to confirming the donor, proceed with an apheresis procedure operated according to the plurality of parameters, the apheresis procedure configured to draw whole blood from a human subject, separate at least one component from the whole blood, and return at least one other component of the whole blood to the donor.

Low volume extracorporeal photopheresis systems and methods

Systems and methods for performing low volume (e.g., 500 mL or less) extracorporeal photopheresis (ECP) procedures are disclosed. Each of the different systems and methods eliminates the need for multiple kits and solutions and reduce some of the potential risks inherent in the use of such multiple kits and solutions.

Systems and methods for converting an apheresis fluid processing circuit to single or double needle mode

Systems and methods for performing apheresis procedures, including photopheresis, are disclosed. The systems and methods utilize a disposable fluid circuit that can be converted from a double needle configuration to a single needle configuration and from a single needle configuration to a double needle configuration. A controller directs the action of system pumps to clear potentially stagnant blood residing in the fluid circuit, tracks system parameters and status before and after conversion, and verifies that the procedure may proceed in its new configuration.

Systems and methods for achieving target post-procedure fraction of cells remaining, hematocrit, and blood volume during a therapeutic red blood cell exchange procedure with optional isovolemic hemodilution

Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.

System and method for adjustment of blood separation procedure parameters

Systems and methods are provided for automatically adjusting the operational parameters of a blood separation procedure. A blood separation device has an inlet for passing fluid thereinto and an outlet for removing fluid therefrom. A pump system is provided for moving fluid into and out of the device. In use, blood is conveyed into the device, where platelets are separated from at least a portion of the blood. A controller determines the amount of platelets in the device. Based at least in part on the amount of platelets in the device, corrective action is taken to avoid platelet aggregation in the device. The corrective action may be conveying an elevated amount of anticoagulant into the blood and/or the device and may be initiated when the determined amount of platelets approaches, meets, or exceeds a threshold predicted likelihood of platelet aggregation.

Collection Of Mononuclear Cells Upon Mid-Procedure Termination

Mid-procedure termination of a mononuclear cell collection procedure may prevent collection of an amount of red blood cells that is required to harvest a complete mononuclear cell product. Blood separation systems and methods are provided for minimizing the impact of or recovering from mid-procedure termination of such a mononuclear cell collection procedure. According to one approach, blood or separated red blood cells are conveyed into a red blood cell collection container relatively early in the procedure to minimize the impact of a later termination of the procedure. According to another approach, blood and/or separated red blood cells within a fluid processing assembly are redirected through the fluid processing assembly following mid-procedure termination to allow for at least partial mononuclear cell collection. According to yet another approach, a double-needle fluid processing assembly may be converted into a single-needle configuration to allow for continued processing following mid-procedure termination.

Device for reducing bending stress in flange connections

Systems and methods for achieving target post-procedure fraction of cells remaining, hematocrit, and blood volume during a therapeutic red blood cell exchange procedure with optional isovolemic hemodilution

Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.

System and methods for separating blood under conditions of reduced plasma clarity

Blood separation systems and methods are provided for separating blood under conditions of reduced plasma clarity. The system may assess plasma clarity by monitoring light transmissivity of plasma or comparing an actual plasma flow rate to an ideal plasma flow rate, with a low flow rate indicating decreased clarity, which may be addressed by increasing the plasma flow rate. For extracorporeal photopheresis, plasma clarity may be a factor in determining the dosage of irradiating light to apply to mononuclear cells. A fluid processing assembly for mononuclear cell collection may include visual indicium, which an operator may use to determine when to end mononuclear cell collection. The system may detect red blood cells flowing toward a mononuclear cell collection container and reverse the direction of flow to prevent red blood cells from entering the container. An operator may also be enabled to selectively begin and/or end harvesting of mononuclear cells.

INHIBITOR COMBINATION FOR LITHIUM SALT TRANSESTERIFICATION PROCESS AND METHOD FOR LITHIUM SALT REMOVAL

COMBINAÇÃO DE INIBIDOR PARA PROCESSO DE TRANSESTERIFICAÇÃO CATALISADA POR SAL DE LÍTIO E MÉTODO PARA REMOÇÃO DE SAL DE LÍTIO. Um processo para formar uma composição compreendendo um polieno assimétrico, o polieno assimétrico compreendendo uma "extremidade carbonil (Alfa),(Beta) insaturada" e uma "extremidade de ligação dupla C-C", o processo compreendendo: reagir um álcool contendo alqueno ou polieno com um alquil éster de um ácido carboxílico (Alfa),(Beta) insaturado na presença de, pelo menos, os seguintes componentes A) a C) para formar uma solução compreendendo um polieno assimétrico: A)um sal de lítio; B) um componente selecionado a partir do grupo que consiste em hidroquinona, um alquil-fenol substituído, um alquil-substituído-fenol substituído, um alquil-hidroquinona substituída, um alquil-substituído-hidroquinona substituída, e combinações dos mesmos; e C)um Composto contendo N-oxil; em que, a "extremidade carbonil (Alfa),(Beta) insaturada" do polieno assimétrico é selecionada a partir do grupo que consiste em estruturas A) a C), como aqui descrito, e em que, a "extremidade de ligação dupla C-C" do polieno assimétrico é selecionada a partir do grupo que consiste em estruturas 1) a 17), como aqui descrito. INHIBITOR COMBINATION FOR LITHIUM SALT TRANSESTERIFICATION PROCESS AND METHOD FOR LITHIUM SALT REMOVAL. A process for forming a composition comprising an asymmetric polyene, the asymmetric polyene comprising an "unsaturated (Alpha),(Beta) carbonyl end" and a "C-C double bond end", the process comprising: reacting an alkene-containing alcohol or polyene with an alkyl ester of an (Alpha),(Beta) unsaturated carboxylic acid in the presence of at least the following components A) to C) to form a solution comprising an asymmetric polyene: A) a lithium salt; B) a component selected from the group consisting of hydroquinone, a substituted alkyl phenol, a substituted alkyl phenol, a substituted alkyl hydroquinone, a ...

Systems and methods for performing online extracorporeal photopheresis

Systems and methods for performing online extracorporeal photopheresis of mononuclear cells are disclosed. During a mononuclear cell collection cycle, blood is removed from a source and separated into a plasma constituent, a mononuclear cell-containing layer, and red blood cells, followed by the collection of a pre-product including at least a portion of the mononuclear cell-containing layer and at least a portion of the separated red blood cells. The mononuclear cell collection cycle may be repeated, followed by the production of a single mononuclear cell product using the collected pre-product(s). The mononuclear cell product is irradiated using a fixed dose of light, such that the mononuclear cell product is produced so as to have a predetermined volume and a predetermined hematocrit, regardless of the number of pre-products used to produce the mononuclear cell product. Following irradiation, at least a portion of the irradiated mononuclear cell product is returned to the source.

System and method for authenticating disposable components in extracorporeal photopheresis

A medical device verification system for an extracorporeal photopheresis procedure comprises a reusable irradiation device comprising a UV light source and a scanner. A fluid circuit comprises a disposable cell suspension container having a photo-reactive label comprising an identifiable code. The identifiable code is unobscured when the label in a first state and is obscured when the label is in a second state. The irradiation step is performed by irradiating the disposable cell suspension container for a predetermined period of time at or above the threshold UV irradiation level. A second input is received from the scanner during the irradiation step, the second input comprising identification of a state of the label. A response action is provided if the first input comprises identification of the second state of the label and/or if the second input comprises identification of the first state of the label.

Systems and methods for photoactivation of a biological fluid

Methods and systems for treating a biological fluid with light are disclosed. The methods and systems provide for determining a target light dose for the biological fluid; loading a treatment container holding the biological fluid into an irradiation chamber of an irradiation device comprising: with the treatment container being supported in the irradiation device in between a first array of light sources and first light energy sensors and a second light energy sensor. The first array of light sources is activated, and a first light intensity is measured with the first light energy sensors. A second light intensity is measured with the second light energy sensor, and the first light intensity is compared to the second light intensity to determine an attenuation factor. The attenuation factor is applied to the first light intensity to determine a time to achieve the target light dose, with the first array of multiple light sources being deactivated after the time to achieve the target light dose has elapsed.

Blood processing and treatment systems and methods with procedure estimator

Systems and methods for the optimization of blood collection and therapies using an automated blood cell separator are disclosed. The systems and methods calculate or determine recommended settings based on, among other things, one or more of historical collection data, set defaults, contamination limits, blood, and blood component characteristics.

Systems and methods for photoactivation of a biological fluid

Methods and systems for treating a biological fluid with light are disclosed. The methods and systems provide for determining a target light dose for the biological fluid; loading a treatment container holding the biological fluid into an irradiation chamber of an irradiation device comprising: with the treatment container being supported in the irradiation device in between a first array of light sources and first light energy sensors and a second light energy sensor. The first array of light sources is activated, and a first light intensity is measured with the first light energy sensors. A second light intensity is measured with the second light energy sensor, and the first light intensity is compared to the second light intensity to determine an attenuation factor. The attenuation factor is applied to the first light intensity to determine a time to achieve the target light dose, with the first array of multiple light sources being deactivated after the time to achieve the target light dose has elapsed.

Systems and methods for monitoring and controlling fluid balance during a biological fluid procedure

Described is a method for controlling fluid volume balance. A controller is configured with a first set of inputs comprising a hematocrit, a total blood volume, and an ACD ratio. A maximum extracorporeal RBC amount during the procedure is estimated based on the first set of inputs. A fluid circuit is primed with a priming fluid. Whole blood is drawn from a blood source and separated into a RBC component, a target cell component, and a plasma component. The target cell component is directed to a product container. The product container comprising the target cell component is treated. A treated target cell component, a portion of the RBC component remaining in the fluid circuit, and/or a portion of the plasma component remaining in the fluid circuit are returned to the blood source. A first response action is provided if the maximum extracorporeal RBC amount estimated is above a programmed limit.

método para preparação de ésteres de (met)acrilato de polissiloxanos

trata-se de um método para preparação de ésteres de (met)acrilato de polissiloxanos. o método compreende contato na presença de acetilacetonato de zircônio ou acetilacetonato de háfnio de: (i) um polissiloxano que tem pelo menos dois grupos hidroxila, cada um dos quais é ligado a um átomo de carbono, e (ii) um (met)acrilato de c1-c4 alquila.

Nontoxic catalyst for preparation of polysiloxane (meth)acrylates

A method for preparation of (meth)acrylate esters of polysiloxanes. The method comprises contacting in the presence of zirconium acetylacetonate or hafnium acetylacetonate: (i) a polysiloxane having at least two hydroxyl groups, each of which is attached to a carbon atom, and (ii) a C 1 -C 4 alkyl (meth)acrylate.

Systems and methods for use and control of an automated separator with adsorption columns

Blood treatment systems and methods are provided for combining a blood separation system and an adsorption device. The blood separation system is configured to separate a blood component from blood, while the adsorption device is configured to receive at least a portion of the separated blood component and process it. The blood separation system includes a fluid flow element and a controller. The fluid flow element is configured for flowing the separated blood component into the adsorption device. The controller controls the fluid flow element based at least in part on one or more processing parameters. The processing parameters include a maximum flow rate of the separated blood component flowed into the adsorption device, a maximum pressure of the separated blood component flowed into the adsorption device, and/or the volume of fluid in a location of the system.

Plasma collection with remote programming

A system and method for collecting plasma includes drawing whole blood from a donor, combining anticoagulant with the whole blood from the donor, separating the whole blood into a plasma product and a second blood component and sending the plasma product to a collection container. A controller receives parameters over a network from a remote computer, receives a user input to confirm the a parameter and/or procedure, determines a target volume for plasma product and/or raw plasma based on the parameters and, in response to confirming the donor, controls the system to collect the plasma using draw and return phases.

Improved method for the preparation of n-oxyl hindered amine inhibitors

The present disclosure provides a composition and method for the preparation of N-oxyl hindered amine esters by contacting a compound of Formula (I), wherein R 1 and R 2 are independently an alkyl, with a compound of Formula (II), wherein R 3 and R 4 are independently an alkyl, and n is an integer from 3 to 10, in the presence of a catalyst and a solvent, wherein the catalyst comprises at least one of tin, lithium, zirconium, and hafnium.

用於製備ｎ－氧基位阻胺抑制劑之改良方法

本發明提供一種用於製備N-氧基位阻胺酯之組成物及方法，該方法係藉由使式I化合物：□其中R1及R2獨立地為烷基，與式II化合物□其中R3及R4獨立地為烷基，且n為3至10之整數，在催化劑及溶劑存在下接觸而達成，其中該催化劑包含錫、鋰、鋯及鉿中之至少一者。

Plasma collection

A system and method for collecting plasma includes drawing whole blood from a donor, combining anticoagulant with the whole blood from the donor, separating the whole blood into a plasma product and a second blood component and sending the plasma product to a collection container. A controller determines a total blood volume for a donor based on donor weight, height and gender. The system comprises a touchscreen for receiving a confirming user input and a scanning device configured to scan a bar code associated with a donor. The system and method operate a plurality of draw and return phases.

Plasma collection

A system and method for collecting plasma includes drawing whole blood from a donor, combining anticoagulant with the whole blood from the donor, separating the whole blood into a plasma product and a second blood component and sending the plasma product to a collection container. A controller determines a total blood volume for a donor based on donor weight, height and gender. The system comprises a touchscreen for receiving a confirming user input and a scanning device configured to scan a bar code associated with a donor. The system and method operate a plurality of draw and return phases.

Plasma collection with remote programming

Systems and methods for performing online extracorporeal photopheresis

Systems for photoactivation of a biological fluid

Travamento automático para junta telescópica de um sistema de tubo ascendente

Patente de Invenção: <B>"TRAVAMENTO AUTOMáTICO PARA JUNTA TELESCóPICA DE UM SISTEMA DE TUBO ASCENDENTE"<D>. Mecanismo de travamento automático para uma junta telescópica para um tubo ascendente funciona de diversos modos. Em um modo de operação, a junta está livre para ter seus cilindros interno e externo em movimento com relação um ao outro, sem encaixar um com o outro em uma relação de travamento. Em uma segunda posição, a junta telescópica trava, quando está completamente retraída. Em uma terceira posição, o sistema trava os cilindros interno e externo juntos, a fim de mantê-los em uma posição fixa. Os cilindros interno e externo são travados, quando uma luva móvel é adequadamente posicionada, a fim de permitir que ganchos carregados a mola sejam impulsionados através de janelas na luva, de modo a atuar como um ressalto de aterrissagem, para prender uma ranhura no cilindro externo. Através da colocação da luva de atuação em uma variedade de posições, os vários modos do conjunto de travamento podem ser desdobrados.

Systems for photoactivation of a biological fluid

Automatic lock for telescoping joint of a riser system

Inhibitor combination for lithium salt-catalyzed transesterification process and method for removing lithium salt

A process to form a composition comprising an asymmetrical polyene, the asymmetrical polyene comprising an “α,β unsaturated-carbonyl end” and a “C—C double bond end,” the process comprising: reacting an alkene- or polyene-containing alcohol with an alkyl ester of an α,β unsaturated carboxylic acid in the presence of at least the following components A) through C) to form a solution comprising an asymmetrical polyene: A) a lithium salt; B) a component selected from the group consisting of hydroquinone, an alkyl-substituted phenol, a substituted alkyl-substituted phenol, an alkyl-substituted hydroquinone, a substituted alkyl-substituted hydroquinone, and combinations thereof; and C) an N-oxyl-containing compound; wherein the “α,β unsaturated-carbonyl end” of the asymmetrical polyene is selected from the group consisting of structures a) through c), as described herein, and wherein the “C—C double bond end” of the asymmetrical polyene is selected from the group consisting of structures 1) through 17), as described herein.