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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 2102. Отображено 100.
26-01-2012 дата публикации

Methods and apparatus for assesment and treatment of body cavities

Номер: US20120022380A1
Автор: Ary S. Chernomorsky
Принадлежит: Transmed7 LLC

Methods and apparatus for detection, assessment and optionally treatment of the cancerous tissue in the natural and manmade body cavities. An expandable cavity assessment device that is coupled with cancer detecting elements is placed in a cavity in close proximity to the site of cancerous tissue. The cavity assessment device may receive an optical fiber, or other type of energy conduit and potentially a radioactive source for interstitial radiation therapy. The cavity assessment device may be equipped with a balloon member coupled with electro conductive elements. Further, a system facilitating substance communication with the internal surface of the cavity is provided.

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Номер записи: 1
16-02-2012 дата публикации

Apparatus and Method for Capsule Formation in Tissue

Номер: US20120041393A1
Автор: Donald Shannon, Frank Ahmann, Hani Sabbah
Принадлежит: CARDIOPOLYMERS Inc, HENRY FORD HEALTH SYSTEM

Capsules, emplacement apparatus, and associated methods for establishing a capsule within tissue are described herein. The emplacement apparatus may be catheter-based or implemented in a handheld unit. The emplacement apparatus serves to introduced an encapsulating membrane in a collapsed condition into the tissue, and then to expand the encapsulating membrane within the tissue into a capsule by injection of fill material into the encapsulating membrane. Other than being capable of injection through the emplacement apparatus, the fill material may be selected and formulated to achieve such mechanical and biological properties within the encapsulating membrane after injection as are desired to achieve the therapeutic effect sought for the patient. Mechanically, the fill material within the encapsulating membrane after injection may be a liquid, a semi-solid such as a gel, or a solid such as a cross-linked polymer. The fill material may or may not be sealed within the encapsulating membrane.

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Номер записи: 2
12-04-2012 дата публикации

Catheter Assembly Including Triple Lumen Tip

Номер: US20120089070A1
Автор: Ryan T. Moehle, Scott W. Sanders, William R. Barron
Принадлежит: CR Bard Inc

A catheter assembly for use in accessing a vasculature of a patient during renal replacement or other therapies is disclosed. In one embodiment, the catheter assembly includes a catheter body that defines first and second lumens. The catheter body defines a distal tip region that includes a venous lateral opening that is in fluid communication with the first lumen and an arterial lateral opening that is in fluid communication with the second lumen.

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Номер записи: 3
03-05-2012 дата публикации

Agents and methods for denervation

Номер: US20120108517A1
Автор: Emily A. STEIN, Kondapavulur T. Venkateswara-Rao, Michael A. Evans
Принадлежит: Evans Michael A, Stein Emily A, Venkateswara-Rao Kondapavulur T

Various agents are described to denerve, modulate, or otherwise affect the renal nerves and other neural tissue. Also, various delivery devices are described to deliver an agent locally to the renal nerves. The delivery devices are positioned in the renal artery and penetrate into the wall of the renal artery to deliver the agent to the renal nerves. The delivery devices may be used to deliver the agent according to longitudinal position, radial position, and depth of the renal nerves relative to the renal artery. In addition, various methods are described to denervate, modulate, or otherwise affect the renal nerves and other neural tissue.

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Номер записи: 4
28-06-2012 дата публикации

Coaxial guide catheter for interventional cardiology procedures

Номер: US20120165756A1
Автор: Gregg Sutton, Howard Root, Jason M. Garrity, Jeffrey M. Welch
Принадлежит: Vascular Solutions LLC

A coaxial guide catheter to be passed through guide catheter having a first lumen, for use with interventional cardiology devices that are insertable into a branch artery that branches off from a main artery. The coaxial guide catheter is extended through the lumen of the guide catheter and beyond the distal end of the guide catheter and inserted into the branch artery. The device assists in resisting axial and shear forces exerted by an interventional cardiology device passed through the second lumen and beyond the flexible distal tip portion that would otherwise tend to dislodge the guide catheter from the branch artery.

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Номер записи: 5
28-02-2013 дата публикации

Expandable catheter system for fluid injection into and deep to the wall of a blood vessel

Номер: US20130053822A1
Автор: David R. Fischell, Tim A. Fischell
Принадлежит: Ablative Solutions Inc

A catheter-based/intravascular fluid injection system with application to renal denervation includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic and/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable delivery system includes expandable components that facilitate positioning of a multiplicity of injection needles against the inside wall of a blood vessel from where they can be advanced. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel.

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Номер записи: 6
09-05-2013 дата публикации

Mri-guided devices and mri-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time

Номер: US20130116543A1
Автор: Kamal Vij, Kimble L. Jenkins, Peter Piferi
Принадлежит: MRI Interventions Inc

An MRI-guided medical device includes an elongated sheath, an elongated dilator, and an elongated needle. The sheath has a distal end, an opposite proximal end, and a central lumen extending between the proximal and distal ends. The sheath comprises MRI-compatible material and includes a tracking member located adjacent to the sheath distal end that is visible in an MRI image. The dilator comprises MRI-compatible material and is movably disposed within the sheath lumen. A distal end of the dilator is configured to extend outwardly from the sheath distal end and dilator includes at least one tracking member that is visible in an MRI image. The needle is movably disposed within the dilator lumen and is movable between stored and operative positions relative to the dilator. An RF shield may be coaxially disposed within the elongated sheath so as to surround a portion of the sheath central lumen.

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Номер записи: 7
15-08-2013 дата публикации

Neural injection system and related methods

Номер: US20130211383A1
Автор: N. Sandor Racz
Принадлежит: Custom Medical Applications Inc

A novel neural injection system and related methods are herein disclosed. Various embodiments of an embodiment of a neural injection system of the present invention provide for at least one benefit of enhanced injection characteristics, increased operational efficiency, reduced cost per unit, reduced incidence of injury through intraneural/intravascular injection, reduced incidence of injury through pricking/piercing, and/or the like.

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Номер записи: 8
05-12-2013 дата публикации

Ablation device with drug delivery component

Номер: US20130324911A1
Автор: Allison Waller, Clifford J. Herman, Francesca Rossetto, Lan Pham, Les Hull, Paul DiCarlo, Phillip D. Blaskovich, Rachit Ohri, Richard Huang, Rupal Ayer, Stephen H. Wu, William H. Nau, JR.
Принадлежит: COVIDIEN LP

An ablation system includes a source of electrosurgical energy, a source of coolant fluid, and an ablation electrode assembly operatively connected to the source of electrosurgical energy and fluidly-coupled to the source of coolant fluid. The ablation electrode assembly includes a hub defining a chamber therein and one or more electrically-conductive ablation needles extending from the hub. The ablation system also includes one or more delivery needles extending from the hub. The one or more delivery needles are selectively moveable from a first position, wherein the distal end of the delivery needle is disposed proximal to the distal end portion of the ablation needle, to at least a second position, wherein at least the distal end of the delivery needle is disposed distally beyond the distal end portion of the ablation needle.

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Номер записи: 9
19-12-2013 дата публикации

Methods And Compositions For Treating Post-Cardial Infarction Damage

Номер: US20130338634A1
Автор: Gregory Waimong Chan, Shubhayu Basu, Sungwoo Min
Принадлежит: Abbott Cardiovascular Systems Inc

Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.

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Номер записи: 10
09-01-2014 дата публикации

Apparatus and method for gastric bypass surgery

Номер: US20140012248A1
Автор: Robert L. Wilcox, Stefan Josef Matthias Kraemer, Thomas James Clement
Принадлежит: Individual

A medical treatment device includes an elongate member having an internal volume, a proximal end, and a distal end, the internal volume extending from the proximal end to the distal end. The medical treatment device further includes a first coupler and a second coupler, the first coupler and the second coupler coupled to the internal volume of the elongate member; a first joining member and a second joining member, the first joining member coupled to the first coupler and the second joining member coupled to the second coupler. The first joining member is configured to attach to a first biological matter location, and the second joining member is configured to attach to a second biological matter location, the second location being distal to the first location. The second coupler is configured for manipulation to align relative the first coupler such that the second biological matter location relocates adjacent the first biological matter location. The first joining member and the second joining member are configured to join the first biological matter location to the second biological matter location.

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Номер записи: 11
02-01-2020 дата публикации

SYSTEMS, DEVICES AND METHODS FOR THE CREATION OF A THERAPEUTIC RESTRICTION IN THE GASTROINTESTINAL TRACT

Номер: US20200001047A1
Автор: Caplan Jay, FLAHERTY J. Christopher, Flaherty R. Maxwell, Rajagopalan Harith
Принадлежит: Fractyl Laboratories Inc.

A system for treating a patient comprises a delivery device and injectate. The delivery device comprises an elongate shaft with a distal portion and at least one delivery element positioned on the elongate shaft distal portion. The delivery device is constructed and arranged to deliver the injectate through the at least one delivery element and into tissue to create a therapeutic restriction in the gastrointestinal tract. Methods of creating a therapeutic restriction are also provided. 1. (canceled)2. A method of treating a patient comprising:advancing a fluid delivery element to a location proximate a luminal segment of the gastrointestinal tract of the patient; anddelivering an injectate through the delivery element and into tissue proximate the luminal segment to create a therapeutic restriction in the luminal segment;wherein the therapeutic restriction causes a loss of weight to the patient.3. The method of claim 2 , wherein the therapeutic restriction is constructed and arranged to restrict the passage of food through a portion of the gastrointestinal tract of the patient.4. The method of claim 2 , wherein the therapeutic restriction is constructed and arranged to cause at least one of: early satiety; premature satiety; or satiety.5. The method of claim 2 , wherein the therapeutic restriction is constructed and arranged to alter an absorptive property and/or a secretive property of the gastrointestinal tract of the patient.6. The method of claim 2 , wherein the therapeutic restriction is created by injecting a volume of injectate of at least 1.0 mL.7. The method of claim 6 , wherein the therapeutic restriction is created by injecting a volume of injectate of at least 3.0 mL.8. The method of claim 2 , wherein the therapeutic restriction is created by injecting a volume of injectate of no more than 20.0 mL.9. The method of claim 8 , wherein the therapeutic restriction is created by injecting a volume of injectate of no more than 10.0 mL.10. The method of claim 2 ...

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Номер записи: 12
12-01-2017 дата публикации

INJECTATE DELIVERY DEVICES, SYSTEMS AND METHODS

Номер: US20170007324A1
Автор: Caplan Jay, Coats Andrew, FLAHERTY J. Christopher, Flaherty R. Maxwell, Kadamus Christopher J., Manasas Mark A., Rajagopalan Harith
Принадлежит:

An injectate delivery device for expanding tissue is provided. The injectate delivery device comprises: at least one fluid delivery tube comprising a proximal end, a distal end and a lumen therebetween; at least one fluid delivery element in fluid communication with the at least one fluid delivery tube lumen; a radially expanding element comprising the at least one fluid delivery element; a supply of vacuum constructed and arranged to cause tissue to tend toward the at least one fluid delivery element; and at least one control constructed and arranged to perform a function. The at least one control can be constructed and arranged to expand the radially expandable element and activate the supply of vacuum. Systems and method of injectate delivery are also provided. 1. An injectate delivery device for expanding tissue comprising:at least one fluid delivery tube comprising a proximal end, a distal end and a lumen therebetween;at least one fluid delivery element in fluid communication with the at least one fluid delivery tube lumen;a radially expanding element comprising the at least one fluid delivery element;a supply of vacuum constructed and arranged to cause tissue to tend toward the at least one fluid delivery element; andat least one control constructed and arranged to:expand the radially expandable element; andactivate the supply of vacuum;wherein the device is constructed and arranged to deliver an injectate to target tissue through the at least one fluid delivery element.2. The injectate delivery device according to any claim herein , wherein the at least one control is further constructed and arranged to advance the at least one fluid delivery element.3. The injectate delivery device according to claim 2 , wherein the at least one control is constructed and arranged to advance the at least one fluid delivery element while limiting force applied to fluid delivery element.4. The injectate delivery device according to claim 2 , further comprising a compression ...

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Номер записи: 13
11-01-2018 дата публикации

CATHETER TIP ASSEMBLED WITH A SPRING

Номер: US20180008800A1
Автор: CHAPPEL Shlomit, RICHTER Jacob
Принадлежит:

A catheter tip having a spring element that imparts longitudinal flexibility, pushability and radial rigidity to the catheter tip, thereby improving deliverability, is provided. The spring element also provides radial support to the distal edge of the catheter tip. The spring element may taper distally, but may have a substantially constant inner luminal diameter. The spring element may be partially covered or embedded, leaving its distal end exposed. The spring element may also include spaced coils in a proximal region. The apparatus may be used with any interventional catheter system, but is particularly suitable for use with balloon-expandable stent systems and balloon-angioplasty systems, where flexibility of the catheter tip and minimal flaring of the distal edge of the catheter tip is desirable. 119-. (canceled)20. A flexible catheter , comprising:a longitudinal catheter body extending from a proximal end to a distal end; anda flexible catheter tip located at said distal end of said catheter body, said flexible catheter tip including a spring element having a proximal end and a distal end that is a distal-most end of the catheter, said spring element defining an inner lumen having an inner luminal diameter and an outer diameter;wherein said spring element is a wire coil having pitch space between two or more coils in a first region and tightly packed coils in a second region, said second region being distal of said first region, andwherein said wire coil having a decreasing cross-sectional diameter from the proximal end of the spring element to the distal end of the spring element.21. The catheter of claim 20 , wherein the wire coil further comprises a first coil diameter at the proximal end of the spring element and a second coil diameter at the distal end of the spring element.22. The catheter of claim 21 , wherein the first coil diameter is 0.1 mm and the second coil diameter is 0.05 mm.23. The catheter of claim 21 , wherein the second coil diameter is 30- ...

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Номер записи: 14
27-01-2022 дата публикации

FENESTRATION DEVICES, SYSTEMS, AND METHODS

Номер: US20220023589A1
Автор: Cully Edward H., Eskaros Sherif A., Houge Reed A., Mokelke Eric A.
Принадлежит:

An endoluminal access device including an outer sheath defining a lumen and a guide assembly. The guide assembly includes an expandable portion configured to be transitioned between a collapsed configuration having a first diameter and an expanded configuration having a second diameter that is greater than the first diameter. The expandable portion includes a first arm defining a first lumen and an aperture in communication with the first lumen. The expandable portion is configured to expand outwardly from a central longitudinal axis when the expandable portion transitions to the expanded configuration and to deflect inwardly toward the central longitudinal axis when the expandable portion is transitioned to the collapsed configuration. The endoluminal access device further includes an endoluminal tool deliverable from the first lumen of the first arm and outwardly from the aperture of the first arm. 1. An endoluminal access device comprising:an outer sheath defining a lumen; 'a first arm defining a first lumen and an aperture in communication with the first lumen, the expandable portion being configured to expand outwardly from a central longitudinal axis when the expandable portion transitions to the expanded configuration and to deflect inwardly toward the central longitudinal axis when the expandable portion is transitioned from the expanded configuration to the collapsed configuration; and', 'an expandable portion configured to be transitioned between a collapsed configuration having a first diameter and an expanded configuration having a second diameter that is greater than the first diameter, the expandable portion including, 'a guide assembly including,'}an endoluminal tool deliverable from the first lumen of the first arm and outwardly from the aperture of the first arm.2. The endoluminal access device of claim 1 , wherein the endoluminal tool is slidably received within the first lumen.3. The endoluminal access device of claim 1 , wherein the endoluminal ...

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Номер записи: 15
10-01-2019 дата публикации

SYSTEMS AND METHODS FOR REDUCING OR PREVENTING BACKFLOW IN A DELIVERY SYSTEM

Номер: US20190009055A1
Автор: Anand PJ, Sama Blake, Singh Deep Arjun
Принадлежит: ALCYONE LIFESCIENCES, INC.

Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid. 126-. (canceled)27. A micro-molding device , comprising:a mold cavity sized and configured to receive a catheter body and a catheter micro-tip therein such that at least one fluid channel of the micro-tip is at least partially disposed within a corresponding fluid line of the catheter body; andone or more mold channels though which a mold fluid can be injected to fill the mold cavity and secure the micro-tip to the catheter body such that the at least one fluid channel of the micro-tip is in fluid communication with the at least one fluid line of the catheter body.28. The device of claim 27 , wherein the device is transparent to allow UV light to pass therethrough to cure mold fluid disposed within the mold cavity.29. The device of claim 27 , wherein the mold cavity is sized and configured to form a bullet nose portion over the micro-tip and over at least a portion of an outer sheath received in the mold cavity.3038-. (canceled) This application is a continuation of U.S. application Ser. No. 14/132,762 filed on Dec. 18, 2013, which claims priority to U.S. Provisional Application No. 61/738,850 filed on Dec. 18, 2012 and U.S. Provisional Application No. 61/835,912 filed on Jun. 17, 2013, which are each incorporated herein by reference in their ...

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Номер записи: 16
10-01-2019 дата публикации

MEDICINE INJECTION CATHETER AND MEDICINE INJECTION SYSTEM

Номер: US20190009056A1
Автор: Ishii Naoki, SHIMADA Naoya
Принадлежит: TERUMO KABUSHIKI KAISHA

A medicine injection catheter includes: a catheter main body formed with a medicine supply lumen; a tubular body connected to the distal end of the catheter main body and having a lumen communicating with the medicine supply lumen; an injection needle connected to the tubular body; a tubular cover member that accommodates the tubular body and that is configured to be advanced and retracted in the axial direction of the catheter main body between a first position where a distal end of the injection needle is accommodated in the tubular cover and a second position where the distal end of the injection needle protrudes forward from the inside space; a closing member to close and open the lumen of the tubular body, a motion conversion mechanism which converts advancing/retracting motion of the cover member into movement of the closing member to close the lumen of the tubular body. 1. A medicine injection catheter for injecting medicine through a wall of a living body , the medicine injection catheter comprising:an elongated catheter main body extending in an axial direction, the catheter main body possessing a distal end and including a medicine supply lumen;a tubular body connected to the distal end of the catheter main body, the tubular body including a lumen communicating with the medicine supply lumen;an injection needle connected to a distal end of the tubular body, the injection needle possessing a distal end;a tubular cover member that includes an inside space in which is accommodated at least the tubular body, the tubular cover member being disposed at a distal end portion of the catheter main body and being configured to undergo advancing/retracting motion along the axial direction of the catheter main body to move between a first position in which the distal end of the injection needle is accommodated in the inside space and a second position in which the distal end of the injection needle protrudes distally beyond the distal end of the catheter main body and ...

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Номер записи: 17
03-02-2022 дата публикации

Devices and methods for selectively deploying catheter instruments

Номер: US20220032007A1
Автор: Erik Delly, Fredrick J. Kim, Gregory R. Eberl, Jeffrey J. Lesica, Michael G. Curley, Michael T. Howard
Принадлежит: Thermedical Inc

Catheters with deployable instruments (e.g., needles) can damage tissue if the instrument unintentionally deploys during use. Described herein are devices and methods for controlling the position of a deployable catheter instrument. In one embodiment, a catheter can include an instrument slidably disposed within an inner lumen of the catheter and coupled to at least one protrusion, as well as a retraction stop coupled to the catheter. The catheter can further include a biasing element coupled to the instrument that can urge the instrument proximally such that the at least one protrusion abuts against the retraction stop, as well as an advancing mechanism to selectively engage the instrument and urge it distally. In some embodiments, the biasing element can be omitted and a deployment stop can be included distal to the retraction stop. These configurations can prevent unintentional instrument deployment and provide greater positioning precision during instrument deployment.

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Номер записи: 18
19-01-2017 дата публикации

Apparatus for treating asthma using neurotoxin

Номер: US20170014571A1
Автор: Hanson S. Gifford, Iii, Mark E. Deem
Принадлежит: Holaira Inc

Apparatus for providing intrabronchial delivery of neurotoxins to control the effects of asthma comprises a shaft having proximal and distal ends and a neurotoxin applicator assembly disposed on the distal end. The neurotoxin applicator assembly comprises a deployable needle assembly, a rotating needle assembly, and a needle-less injection assembly or a nebulizer assembly.

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Номер записи: 19
17-01-2019 дата публикации

MEDICINE INJECTING CATHETER AND MEDICINE INJECTING SYSTEM

Номер: US20190015632A1
Автор: Ishii Naoki, SHIMADA Naoya
Принадлежит: TERUMO KABUSHIKI KAISHA

A medicine injecting catheter includes a catheter body having a medicine supply lumen, a tubular body coupled to a distal end of the catheter body and having a lumen fluidly communicating with the medicine supply lumen, an injection needle connected to a distal end of the tubular body, a cover member having an interior housing the tubular body, with the cover member disposed on the distal end of the catheter body for reciprocating axial movement between a first position in which the distal end of the needle is in the inner space and a second position in which the distal end of the needle projects forwardly from the inner space, and an opening/closing mechanism for opening/closing the tubular body lumen depending on an angular position of an operating member, and a motion converting mechanism for converting reciprocating movement of the cover member into rotary movement of the operating member. 1. A medicine injecting catheter for injecting medicine into a wall of a living body , the medicine injecting catheter comprising:an elongate catheter body extending in an axial direction, the catheter body possessing a distal end and including a medicine supply lumen extending in the catheter body;a tubular body connected to the distal end of the catheter body, the tubular body including a lumen in fluid communication with the medicine supply lumen;an injection needle connected to the distal end of the tubular body, the injection needle possessing a distal end;a hollow cover member that includes an inner space in which is accommodated at least the tubular body, the cover member being disposed on a distal end portion of the catheter body for reciprocating movement along the axial direction of the catheter body between a first position in which the distal end of the injection needle is housed in the inner space and a second position in which the distal end of the injection needle projects forwardly from the inner space;an opening and closing mechanism that includes an operating ...

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Номер записи: 20
16-01-2020 дата публикации

STEERABLE ENDOSCOPE WITH CONTINUUM MANIPULATOR

Номер: US20200015657A1
Автор: Garbin Nicolo, Obstein Keith L., Simaan Nabil, Slawinski Piotr Robert, Valdastri Pietro
Принадлежит:

A steerable endoscope system includes a continuum manipulator, a plurality of syringes, and a steerable tip. The continuum manipulator includes a plurality of spaced discs and a plurality of backbones each extending through all discs. A bending movement of the continuum manipulator changes a varying linear displacement of each backbone. Each backbone is further coupled to a different one of the syringes such that the linear displacement of each backbone pushes or pulls a piston of the corresponding syringe by a varying amount. The steerable tip includes a plurality of bellows each pneumatically coupled to a different syringe such that movement of the piston of a syringe causes the corresponding bellow to inflate or deflate. Because the distal end of each bellow is fixedly coupled to the same end effector, variations in the amount of inflation or deflation on each bellow causes a bending of the steerable tip. 1. A steerable endoscope system comprising: a plurality of spaced discs each including a plurality of backbone openings, and', 'wherein the continuum manipulator is configured such that a bending movement of the continuum manipulator changes a linear displacement of the distal end of each backbone of the plurality of backbones extending from the distal end of the continuum manipulator;', 'a plurality of backbones each including a proximal end fixedly coupled to a proximal end of the continuum manipulator and a distal end extending from a distal end of the continuum manipulator, wherein each backbone of the plurality of backbones slidably extends through a backbone opening of each disc of the plurality of spaced discs,'}], 'an continuum manipulator including'}a plurality of syringes coupled to the continuum manipulator, wherein each syringe of the plurality of syringes is coupled to the distal end of a different one of the plurality of backbones such that linear displacement of a backbone in a first direction pushes a piston of the syringe and linear displacement ...

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Номер записи: 21
15-01-2015 дата публикации

MEDICAL TREATMENT INSTRUMENT

Номер: US20150018616A1
Автор: KUMOYAMA Kenichi
Принадлежит:

A medical treatment instrument includes a tube-shaped elongated main body; and an insertion guide part mounted to a distal end of the elongated main body. The insertion guide part includes a frame body mounted to a distal portion of the elongated main body; and a flexible bridge portion which is disposed so as to bridge points of an end edge of the frame body, the flexible bridge portion including a linear body or band-shaped body projecting in a distal direction beyond the elongated main body. 1. A medical treatment instrument comprising:a tube-shaped elongated main body; and a frame body mounted to a distal portion of the elongated main body; and', 'a flexible bridge portion which is disposed so as to bridge points of an end edge of the frame body, the flexible bridge portion comprising a linear body or band-shaped body projecting in a distal direction beyond the elongated main body., 'an insertion guide part mounted to a distal end of the elongated main body, wherein the insertion guide part comprises2. The medical treatment instrument according to claim 1 , wherein the medical treatment instrument comprises a plurality of bridge portions that are provided at different positions of the end edge.3. The medical treatment instrument according to claim 2 , wherein each of the plurality of bridge portions comprises a distal end claim 2 , and the distal ends of each of the plurality of bridge portions are not fixed to each other.4. The medical treatment instrument according to claim 1 , wherein the bridge portion is composed of a band-shaped body claim 1 , and an end portion of the band-shaped body projects in the distal direction beyond the elongated main body.5. The medical treatment instrument according to claim 1 , wherein the insertion guide part decreases in diameter in multiple steps along the distal direction.6. The medical treatment instrument according to claim 3 , wherein the insertion guide part decreases in diameter in multiple steps along the distal ...

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Номер записи: 22
10-02-2022 дата публикации

Optimized Catheter Sheath for Rx Catheter

Номер: US20220040454A1
Автор: Albert Harold Dunfee, Mark Alan Hamm
Принадлежит: Canon USA Inc

A catheter configured for placement within a bodily lumen, comprises: a catheter sheath defining a first lumen for medical tools; and an exchange segment defining a second lumen for a guidewire. A proximal end of the exchange segment is joined with a distal end of the catheter sheath in a lengthwise direction forming an angle therebetween, such that the second lumen is laterally offset by a distance and angled with respect to the first lumen. When the catheter is placed within a patient's anatomy, the catheter sheath and/or the exchange segment straightens out so that the axis of the second lumen and the axis of the first lumen become substantially parallel to each other. The offset distance between the axes of sheath and exchange segment depends mainly on the diameter of the guidewire to be used, on the diameter of the sheath, and the angle of the junction.

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Номер записи: 23
22-01-2015 дата публикации

ENDOVENTRICULAR INJECTION CATHETER SYSTEM WITH INTEGRATED ECHOCARDIOGRAPHIC CAPABILITIES

Номер: US20150025381A1
Автор: Moore Thomas C., Waters Kendall R., Zalesky Paul, ZELENKA Robert
Принадлежит: ACIST MEDICAL SYSTEMS, INC.

Methods of providing image-guided transendocardial injection of a therapeutic agent into a left ventricular wall of a heart. Some methods enable injections into heart tissue under visualization. The methods may include providing an endoventricular injection catheter having integrated echocardiographic capability. The endoventricular injection catheter may have an imaging core and an injection system carried on the elongated body with the imaging core. The method may include positioning the endoventricular injection catheter into the left ventricle of the heart, which inserts the imaging core into the heart. The method may also include transmitting ultrasonic energy via the imaging core, receiving reflected ultrasonic energy at the distal end, visualizing the left ventricular wall of the heart using the imaging core, identifying infarct regions of the left ventricle, and injecting a therapeutic agent into the visualized infarcted regions of the left ventricle using the injection system. 1. A method of providing image-guided transendocardial injection of a therapeutic agent into a left ventricular wall of a heart , comprising:providing an endoventricular injection catheter having integrated echocardiographic capability, the endoventricular injection catheter having an elongated body with a first housing, a second housing and a distal section positioned distal to the second housing in a longitudinal direction, the distal section having a distal end and an imaging core and an injection system carried on the elongated body with the imaging core;positioning the endoventricular injection catheter into the left ventricle of the heart, thereby inserting the imaging core into a heart;transmitting ultrasonic energy via the imaging core;receiving reflected ultrasonic energy at the distal end;visualizing the left ventricular wall of the heart using the imaging core;identifying infarct regions of the left ventricle; andinjecting a therapeutic agent into the visualized infarcted ...

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Номер записи: 24
04-02-2016 дата публикации

METHODS AND APPARATUSES FOR AMNIOTIC FLUID COLLECTION AND ISOLATION OF CELLS

Номер: US20160030489A1
Автор: HERBST Andreas Nils Walter, LARSSON Marcus Kare Torleif, WOODS Niels-bjarne Roland
Принадлежит:

Disclosed herein are methods and apparatuses for the safe, high-yield collection of sterile amniotic fluid. The apparatus are configured to allow sufficient flexibility for the device to gain access to all areas of the amniotic cavity, to allow sufficient stiffness for the amniotic fluid collection device to puncture the amniotic and chorionic membranes, yet allow sufficient suppleness to pose no significant risk of maternal or fetal harm. Further disclosed are cells isolated from the full-term amniotic fluid, and methods for using, reprogramming, and differentiating these cells. 1. An amniotic fluid collection device , comprising:a collection chamber;a collection chamber outlet valve coupled to the collection chamber;a collection chamber inlet valve coupled to the collection chamber;a proximal fluid-extraction tube coupled to the collection chamber inlet valve, the proximal fluid-extraction tube comprising a medical grade material; anda distal fluid-extraction tube coupled to the proximal fluid-extraction tube, the distal fluid extraction tube comprising a transfer portion and an inlet, wherein the inlet comprises a main inlet, a penetrating tip, and one or more lateral inlets.2. An isolated fetal or infant cell , comprising surface expression of a marker selected from the group consisting of CD73 and CD90 , wherein:the surface of the cell is negative for CD105 expression; orthe surface of the cell expresses CD34.3. The isolated cell of claim 2 , wherein the cell comprises surface expression of CD73 and CD90.4. The isolated cell of or claim 2 , wherein the cell surface is negative for CD105 expression and expresses CD34.54. The isolated cell of any of - claims 2 , wherein the cell expresses the transcription factor Oct-4.65. The isolated cell of any of - claims 2 , wherein the cell surface is negative for CD45 surface expression.76. The isolated cell of any of - claims 2 , wherein the cell is adherent.87. The isolated cell of any of - claims 2 , wherein the cell ...

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Номер записи: 25
01-02-2018 дата публикации

APPARATUS FOR TREATING ASTHMA USING NEUROTOXIN

Номер: US20180028748A1
Автор: DEEM Mark E., GIFFORD, III Hanson S.
Принадлежит:

Apparatus for providing intrabronchial delivery of neurotoxins to control the effects of asthma comprises a shaft having proximal and distal ends and a neurotoxin applicator assembly disposed on the distal end. The neurotoxin applicator assembly comprises a deployable needle assembly, a rotating needle assembly, and a needle-less injection assembly or a nebulizer assembly. 1. A delivery device for delivering a treatment fluid to a target treatment area located in a wall of an airway to treat a bronchial condition , the device comprising:a shaft having a proximal end including an inlet port, a distal end and a lumen extending between the inlet port and the distal end; anda needle-less injection assembly coupled to the distal end of the shaft, and comprising at least one fluid injector in fluid communication with the lumen of the shaft, wherein the at least one fluid injector is configured to deliver pressurized fluid from the lumen across an epithelium of the wall of the airway and to the target treatment area to alter the treatment area so as to treat the bronchial condition.2. The device of claim 1 , further comprising a deflection mechanism disposed on the shaft to position the at least one fluid injector adjacent to the wall of the airway at a position radially inward from the target treatment area.3. The device of claim 2 , wherein the deflection mechanism is an inflatable balloon.4. The device of claim 1 , wherein the at least one fluid injector comprises at least one port configured to be placed in apposition to the target treatment area and to deliver a pressurized gas across the epithelium and to the target treatment area.5. The device of claim 1 , wherein the at least one fluid injector comprises an atomizer configured to deliver a fine spray or mist across the epithelium and to the target treatment area.6. The device of claim 5 , wherein the atomizer is positioned at a terminal end of that shaft at the distal end of the shaft.7. The device of claim 1 , ...

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Номер записи: 26
04-02-2021 дата публикации

Catheters, catheter systems, and methods for puncturing through a tissue structure and ablating a tissue region

Номер: US20210031020A1
Автор: Steven Richard Mickelsen
Принадлежит: University of Iowa Research Foundation UIRF

A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can include two catheters that are operatively coupled to one another by magnetic coupling through a tissue structure. The ablation catheter can include electrodes positioned within a central portion. The ablation catheter is positioned such that the central portion of a flexible shaft at least partially surrounds the selected tissue region. Each electrode of the ablation catheter can be activated independently to apply ablative energy to the selected tissue region. The ablation catheter can employ high impedance structures to change the current density at specific points. Methods of puncturing through a tissue structure using the percutaneous catheter system are disclosed. Also disclosed are methods for ablating a selected tissue region using the ablation catheter.

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Номер записи: 27
04-02-2021 дата публикации

Device for treating a part of the human body comprising at least one magnetised needle

Номер: US20210031049A1
Автор: Line Paradis
Принадлежит: Individual

A motorised device for treating a part of the human body, comprises at least: a treatment portion comprising at least one magnetised needle intended to come into contact with a part of the human body; and a motorised drive device connected to the treatment portion and capable of imposing movement upon the at least one magnetised needle, and when this movement is a translational movement the treatment portion comprises a single magnetised needle or a plurality of magnetised needles secured together by welding.

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Номер записи: 28
08-02-2018 дата публикации

Engagement catheter devices, systems, and methods to use the same under suctional tissue engagement

Номер: US20180036514A1
Автор: Ghassan S. Kassab, Jose A. Navia, SR.
Принадлежит: CVDevices LLC

Engagement catheter devices, systems, and methods to use the same under suctional tissue engagement. A method of the present disclosure comprises the steps of engaging a targeted tissue under suction/vacuum using an engagement catheter, delivering a substance into or through the targeted tissue using a needle positioned within a first lumen of the engagement catheter, injecting a fluid within the first lumen of the engagement catheter to flush at least part of the first lumen with the fluid, and suctionally removing the injected fluid from within the first lumen of the engagement catheter.

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Номер записи: 29
12-02-2015 дата публикации

3 DIMENSIONAL SIMULTANEOUS MULTIPLE CORE BIOPSY OR FIDUCIAL MARKER PLACEMENT DEVICE AND METHODS

Номер: US20150045665A1
Автор: Lau Jan R.
Принадлежит:

Systems and methods for non-serial, substantially simultaneous or simultaneous tissue sampling and placement of multiple markers/fiducials in a non-linear, distributed or three dimensional configuration. The systems and methods can be applicable to other forms and combinations of distributed/3 dimensional/spherical localization which may include a single procedure or combination of procedures that may include 3D biopsy, fiducial placement, brachytherapy seed placement, injection/infusion of bioactive materials (e.g., chemotherapy, small molecules, cellular materials, cells, caustic materials, proteolytics, embolic material, glue, etc.), thermally or electrically derived ablation. 1. A method of accessing multiple locations within an organ or tissue , comprising:positioning an introducer at a desired location within the organ or tissue;removing a stylet from the introducer;coupling an access device to the introducer;adjusting the access device to a selected deployment distance;simultaneously or substantially simultaneously deploying multiple tines the deployment distance such that end portions of each of the multiple tines are distributed at spaced locations from one another;using the multiple tines to do one or more of: obtain tissue samples, deploy markers or deliver a therapeutic.2. The method of claim 1 , wherein the using the multiple tines comprises doing two or more of: obtaining tissue samples claim 1 , deploying markers or delivering therapeutics with one or more of the multiple tines.3. The method of claim 1 , wherein the deployment distance of each of the multiple tines is identical or substantially identical.4. The method of claim 3 , wherein the deployment distance of each of the multiple tines is a radial distance from a longitudinal axis of the introducer.511-. (canceled)12. A method of simultaneously or substantially simultaneously obtaining a tissue sample and placing a fiducial marker at multiple locations within an organ or tissue claim 3 , ...

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Номер записи: 30
16-02-2017 дата публикации

CONDUIT GUIDING TIP

Номер: US20170043123A1
Автор: FRANKLIN Curtis J.
Принадлежит:

A catheter tip for guiding the catheter through a patient's blood vessels and keeping the catheter in large vessels and preventing entry into smaller branch vessels. 1. A device for guiding a catheter through a patient's blood vessels comprising:a catheter guiding tip extending distally at a distal end of the catheter with an outer dimension substantially the same as an outer dimension of the catheter, the catheter guiding tip expanding distally to at least one guiding member with a tip portion having a shape in an uncompressed state that is larger than the catheter outer dimension along at least one axis perpendicular to a longitudinal axis of the catheter, the catheter guiding tip portion being deformable for insertion in a sheath larger than the tip portion when the tip portion is compressed but smaller than the tip portion when the tip portion is not compressed and resilient for resuming the shape in the uncompressed shape when not subject to compression forces, wherein the shape of the tip portion in the uncompressed state is formed as a member extending distally and radially to form a substantially hook-shaped member along an axis perpendicular to the longitudinal axis of the catheter, the tip portion transitions to a flattened cross-section as the tip portion hooks around to the most distal point of the tip portion.2. The device of claim 1 , wherein the tip portion hooks circularly around such that a most distal point of the tip portion is positioned near a transition point where the catheter begins to extend radially to form the tip portion.3. The device of claim 1 , wherein the tip portion hooks circularly around such that a most distal point of the tip portion is positioned distal to a transition point where the catheter begins to extend radially to form the tip portion so that the tip portion spirals inward.4. The device of claim 1 , wherein the tip portion is one of a solid member or a tubular member.5. The device of claim 1 , wherein the tip portion is ...

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Номер записи: 31
16-02-2017 дата публикации

ANGLED TIP CATHETER

Номер: US20170043124A1
Автор: Vreeman Daniel J.
Принадлежит:

A catheter having improved ability to cross body passage obstructions and that more easily allows backloading of a guidewire into the lumen of the catheter is comprised of a tip, a shaft, and a lumen. The distal end of the catheter tip is oriented at an angle other than 90° to the lengthwise axis of the catheter lip. A guidewire may be easily backloaded into the elongated catheter lumen at the location of the angled catheter tip. 132-. (canceled)33. A catheter comprising:an elongate shaft having proximal and distal ends, a length extending between the proximal and distal ends, a distal tip having a lengthwise axis and defining the distal end of the shaft, a distal opening defined by the distal end of the shaft, and a lumen extending proximally from the distal opening through the proximal end of the shaft,wherein an entirety of the distal end of the shaft is oriented at an angle other than 90 degrees to the lengthwise axis of the distal tip, andwherein the shaft has a bend at least from the distal tip to a location that is 10 percent of the shaft length proximal from the distal tip.34. The catheter set forth in in combination with a guidewire having proximal and distal ends claim 33 , wherein the proximal end of the guidewire is insertable through the distal opening of the shaft and into the lumen and the shaft is advanceable along the guidewire.35. The catheter set forth in claim 34 , wherein the bend of the shaft has a maximum concavity claim 34 , and wherein the guidewire has a bend having a maximum convex curvature claim 34 , the shaft configured to self-orient on the guidewire as the shaft is advanced along the guidewire such that the maximum concavity of the bend of the shaft aligns with the maximum convex curvature of the guidewire.36. The catheter set forth in claim 35 , wherein the maximum concavity of the shaft is from 0.2 cm to 2 cm as measured over a length of 10 cm.37. The catheter set forth in claim 36 , wherein the maximum concavity of the shaft is one ...

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Номер записи: 32
13-02-2020 дата публикации

MEDICAL DEVICE DELIVERY SYSTEMS AND METHODS

Номер: US20200046534A1
Автор: Chung Karl R., Rudes Susan J.
Принадлежит:

Medical device delivery systems and methods are disclosed. In various examples, the medical device delivery system () includes an elongate element () including an olive (). The olive () includes an opening that exposes a lockwire () extending through a lumen of the olive () such that a linking element () can be coupled to the portion of the lockwire () exposed by the opening, wherein the linking element () provides a coupling to a medical device (). 1. A medical device delivery system comprising:an elongate element;an olive coupled to the elongate element, the olive including a body having a proximal end, a distal end, the olive including a lockwire lumen and the body having an opening formed therein, the opening being formed in the body between the proximal and distal ends such that a portion of the lockwire lumen is exposed;a lockwire removably coupled to the olive, the lockwire extending through the lockwire lumen such that a portion of the lockwire is exposed by the opening formed in the body of the olive, anda linking element removably coupled to the portion of the lockwire extending through the lockwire lumen and exposed by the opening formed in the body of the olive.2. The system of claim 1 , wherein the linking element has a first end and a second end claim 1 , the first end of the linking element being removably coupled to the portion of the lockwire extending through the lockwire lumen and exposed by the opening formed in the body of the olive such that the first end of the linking element is constrained against longitudinal translation along the lockwire beyond the proximal and distal ends of the olive.3. The system of claim 2 , wherein the linking element operates to maintain a position of a medical device along the elongate element during a delivery and deployment of the medical device to a target region within a patient's vasculature.4. The system of claim 3 , wherein the second end of the linking element is coupled to the medical device.5. The system ...

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Номер записи: 33
10-03-2022 дата публикации

CATHETER ASSEMBLY

Номер: US20220072276A1
Автор: FOMINAS Aleksejus, TIERNEY Morgan, TIGHE Cathal
Принадлежит:

A catheter assembly may include a catheter member having a proximal portion and an outer surface; an introducer having a lumen configured to receive the proximal portion of the catheter member; and a sleeve having a compressed portion housed in the lumen of the introducer, the sleeve being configured to evert over the outer surface as the catheter member is inserted through the lumen of the introducer. The proximal portion of the catheter member may be configured to push a distal portion of the sleeve proximally, and the compressed portion of the sleeve may form a soft proximal tip of the catheter assembly as the catheter member exits a proximal opening of the introducer. 1. A catheter assembly comprising:a catheter member having a proximal portion and an outer surface;an introducer having a lumen configured to receive the proximal portion of the catheter member; anda sleeve having a compressed portion housed in the lumen of the introducer, the sleeve being configured to evert over the outer surface as the catheter member is inserted through the lumen of the introducer.2. The catheter assembly of claim 1 , wherein the proximal portion of the catheter member is configured to push a distal portion of the sleeve proximally claim 1 , and the compressed portion of the sleeve forms a soft proximal tip of the catheter assembly as the catheter member exits a proximal opening of the introducer.3. The catheter assembly of claim 1 , wherein the sleeve is not secured to the catheter member.4. The catheter assembly of claim 1 , wherein the introducer includes a cap member having an enlarged proximal surface.5. The catheter assembly of claim 4 , wherein the cap member has a retaining member that covers the sleeve when contained in the introducer and deflects as the catheter member is advanced proximally from the introducer.6. The catheter assembly of claim 5 , wherein the retaining member comprises a plurality of flaps.7. The catheter assembly of claim 5 , wherein the retaining ...

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Номер записи: 34
02-03-2017 дата публикации

Local administration of drugs for the treatment of asthma

Номер: US20170056621A1
Автор: Emily Stein, Kirk Patrick Seward
Принадлежит: Mercator MedSystems Inc

Methods for treating inflammatory pulmonary diseases by administering to the patient an effective amount of one or more pharmaceutical agents are disclosed. The pharmaceutical agents administered can include antibiotics, steroids, NSAIDs, DMARDs, growth factor receptor inhibitors, PI3K inhibitors, neurotransmitter receptor inhibitors, or protease inhibitors. The dose administered is effective to suppress or prevent initiation, progression, or relapses of disease, including the progression of established disease. The pharmaceutical agent is administered to a patient determined to have the disease and at an amount effective to suppress or prevent activity of the disease. The pharmaceutical agent is administered using a transtracheal, transbronchial, or transvascular drug delivery catheter. The pharmaceutical agent can be administered to the patient's pulmonary tissue to suppress reactions in response to bronchial thermoplasty either before, during, or after bronchial thermoplasty.

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Номер записи: 35
28-02-2019 дата публикации

DETECTION DEVICE FOR RECOGNIZING THE EPIDURAL SPACE

Номер: US20190060584A1
Автор: LEE Ye-Jung
Принадлежит: SAEUM MEDITEC CO., LTD

A detection device for recognizing the epidural space is provided. The detection device includes an upper case having a predetermined shape and a lower case coupled to the upper case to form a predetermined space part. A connection tube is provided at a predetermined position of the space part, one end of the connection tube communicates with a paracentesis needle part and the connection tube communicates with a pressure sensor for measuring pressure at a predetermined position of an outer peripheral part thereof. When the paracentesis needle part reaches the epidural space, the device allows a medicine injection catheter to be inserted into the connection tube thereby reaching the epidural space, with the connection tube and the paracentesis needle part connected to each other. 1. A detection device for recognizing an epidural space , comprising:an upper case having a predetermined shape; anda lower case coupled to the upper case to form a predetermined space part,wherein a connection tube is provided at a predetermined position of the predetermined space part, one end of the connection tube communicating with a paracentesis needle part and the other end of the connection tube having a detachable cap part, and an opening in communication with a pressure sensor for measuring pressure being provided at a predetermined position of an outer peripheral part of the connection tube, andwherein, when a paracentesis needle part reaches the epidural space, the detection device allows a medicine injection catheter to be inserted into the connection tube thereby reaching the epidural space, with the connection tube and the paracentesis needle part connected to each other.2. The detection device for recognizing the epidural space according to claim 1 ,wherein the upper case has fixing protrusions for fixing the paracentesis needle part, the lower case has a fixing groove part for fixing and accommodating the paracentesis needle part, and the predetermined space part further has ...

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Номер записи: 36
22-05-2014 дата публикации

Occlusion access system

Номер: US20140142418A1
Автор: Brice Arnault De La Menardiere, Clayton BALDWIN, John Gurley, Joseph Creagan Trautman
Принадлежит: THERIX MEDICAL DEVELOPMENT Ltd

A catheter system for accessing the central venous system through an occlusion in the neck region.

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Номер записи: 37
27-02-2020 дата публикации

Systems, devices, and methods for performing medical procedures in the intestine

Номер: US20200060942A1
Автор: Harith RAJAGOPALAN, J. Christopher Flaherty, Jay Caplan
Принадлежит: Fractyl Laboratories Inc

A method for performing a medical procedure in an intestine of a patient is provided. The method comprises providing a system comprising: a catheter for insertion into the intestine, the catheter comprising: an elongate shaft comprising a distal portion; and a functional assembly positioned on the shaft distal portion and comprising at least one treatment element. The catheter is introduced into the patient, and target tissue is treated with the at least one treatment element. The target tissue comprises mucosal tissue of the small intestine, and the medical procedure can be configured to treat one or more diseases or disorders based on a measured physiologic parameter of the patient.

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Номер записи: 38
27-02-2020 дата публикации

Peri-vascular tissue ablation catheter with support structures

Номер: US20200061348A1
Автор: Andy Edward Denison, Christopher Scott Hayden, Darrin James Kent, David R. Fischell, Eric Thomas Johnson, Jeff Alan Burke, Robert E. Fischell, Robert Ryan Ragland, Tim A. Fischell
Принадлежит: Ablative Solutions Inc

An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

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Номер записи: 39
24-03-2022 дата публикации

MEDICAL DEVICES FOR FLUID DELIVERY

Номер: US20220088350A1
Автор: KIM Eliot T., Lilly Richard S., ORTH Jean C., QUINTOS Robert G., Tun Zaya
Принадлежит:

Medical devices and methods for delivering fluid. The medical devices include one or more needles for delivering fluid. The methods may include expanding an expandable member such as an inflatable member to expand an expandable scaffold outward toward a lumen wall. 1. An intravascular apparatus , comprising:an inflatable balloon carried by a distal region of an elongate member, the inflatable balloon having an expanded configuration when inflated; wherein the expandable infusion scaffold is adapted and positioned about the inflatable balloon such that inflation of the balloon causes the scaffold to expand radially and a circumferential distance between the at least first and second expandable infusion spines to increase as the balloon is inflated, each of the at least first and second infusion spines, in a side view of the apparatus, having a section that extends axially along the balloon in a balloon region that includes a radially outermost surface of the inflatable balloon when the inflatable balloon is in the expanded configuration, the section including the two or more spaced apart radial openings,', 'wherein each of the spines is flexible along at least a portion of its length and has a flexibility that varies in at least the section; and, 'an expandable infusion scaffold comprising at least first and second and expandable infusion spines, each of the at least first and second infusion spines defining a lumen therein and each including two or more spaced apart radial openings therethrough,'} a rail that includes a rail lumen, a plurality of needles, and each of the plurality of needles coupled to and in fluid communication with one of a plurality of fluid delivery lumens that are disposed within the rail lumen,', 'wherein the plurality of needles and the plurality of fluid delivery lumens are coupled to the rail such that movement of the rail within the corresponding infusion spine moves the plurality of the needles and the plurality of fluid delivery lumens ...

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Номер записи: 40
07-03-2019 дата публикации

SYSTEM AND METHOD FOR DELIVERY OF THERAPEUTIC AGENT THROUGH A CATHETER

Номер: US20190070389A1
Автор: Jayaraman Swaminathan
Принадлежит:

A system and method for delivering a therapeutic agent such as filler materials, biocompatible gels, and other substances through a catheter. The therapeutic agent can be a single component or multiple components that are delivered separately or mixed just prior to delivery or at the delivery site. The system and method use an automated delivery mechanism to maximize delivery of the therapeutic agent to the target tissue and minimize loss of the therapeutic agent within the catheter. The system and method are particularly useful for interventional approaches that deliver therapeutic agents to the wall of the heart. 1. A system for delivery of a therapeutic agent through a catheter to target tissue , the system comprising:an injection catheter having a head at a distal end, a proximal end opposite the distal end, and a shaft extending between the distal and proximal ends;a plurality of needles disposed in the catheter head movably between a retracted position in which the needles are located within the catheter head and an extended position in which front ends of the needles project from the catheter head through openings formed therein, each of the plurality of needles being hollow so as to have a needle passage;a multi-lumen hose upon which the needles are mounted, the multi-lumen hose longitudinally movably supported within the catheter and having a plurality of individual passages, each of the plurality of individual passages in fluid communication with a respective one of the needle passages;an activation mechanism on the catheter shaft for longitudinally moving the multi-lumen hose to selectively deploy the needles into the extended position and retracted position, the activation mechanism operatively associated with the catheter shaft and the multi-lumen hose; andan automated delivery device having a controller for controlling rate of delivery and timing of release of the therapeutic agent and at least one chamber containing the therapeutic agent, each of the ...

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Номер записи: 41
18-03-2021 дата публикации

Methods of making and implanting barbed microcatheters having fluid egress openings for infusing therapeutic fluids

Номер: US20210077781A1
Автор: Frank Richard Cichocki, Jr., Scott Ciarrocca
Принадлежит: Ethicon Inc

A method of making a barbed microcatheter having fluid egress openings includes obtaining a barbed microcatheter blank having a hollow tube with a proximal end, a distal end, and an elongated lumen that extends between the proximal and distal ends of the hollow tube, and first and second flattened regions that extend along opposite sides of the hollow tube. The method includes removing material from the first and second flattened regions of the barbed microcatheter blank to form barbs projecting outwardly from the opposite sides of the hollow tube, and using cutting elements for forming fluid egress openings in a wall of the hollow tube that are in fluid communication with the elongated lumen of the hollow tube. The method includes forming a tissue anchor that is connected with the proximal end of the hollow tube, and securing a surgical needle with the distal end of the hollow tube.

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Номер записи: 42
19-03-2015 дата публикации

Aspiration Thrombectomy Catheter System, And Associated Methods

Номер: US20150080853A1
Автор: Ron Smalling
Принадлежит: Smalling Medical Ventures LLC

An aspiration thrombectomy catheter system includes an aspirator and an aspiration catheter for insertion in a blood vessel. The catheter has a shaft with a proximal end for connection with the aspirator and a tapering distal end with a tip for insertion in the vessel. A plurality of aspiration ports are arranged in sets along the tapering distal end, for aspirating thrombus from the vessel. At least one aspiration lumens within the shaft conducts thrombus from the vessel, through the aspiration ports, to the aspirator. Variably sized or shaped ports provide differing aspiration vectors for enhanced thrombus removal. The aspiration thrombectomy catheter additionally provides for uniform drug dispersion at a thrombotic area, alone or in combination with aspiration of the thrombus. In the event of an adverse reaction, drug dosage may be easily reduced by aspirating dispersed drugs back into the catheter.

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Номер записи: 43
05-06-2014 дата публикации

Methods and apparatus for introducing tumescent fluid to body tissue

Номер: US20140155879A1
Автор: Anna Grace Prestezog, Brady D. Esch, Halil Ibrahim Karabey, Jeff Zalewski, Michael S. Mirizzi, Robert Gordon Mcrae, Todd Schoenberger
Принадлежит: COVIDIEN LP

A catheter is usable to treat a hollow anatomical structure (HAS). The catheter comprises one or more shafts which extend away from a proximal end of the catheter toward a distal end thereof. The catheter further comprises an HAS constriction energy source located at or near the distal end of the catheter. The catheter further comprises at least one radially expandable transmural fluid delivery channel located in the catheter near the HAS constriction energy source.

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Номер записи: 44
26-03-2015 дата публикации

CATHETER HAVING A READILY BONDABLE MULTILAYER SOFT TIP

Номер: US20150088063A1
Автор: Lee Jeong S., Wantink Kenneth L.
Принадлежит:

A balloon catheter having a soft distal tip member having a non-tacky inner (liner) layer material and a soft flexible outer layer material, with both materials being readily thermally bondable to the catheter balloon. 120-. (canceled)21. A balloon catheter , comprising:a) an elongated catheter shaft having a proximal end, a distal end, a proximal shaft section, a distal shaft section, a guidewire receiving lumen extending along at least a distal portion of the catheter shaft, and an inflation lumen;b) a distal tip member located at a distal end of the catheter having a proximal end and a lumen which extends to a guidewire distal port in communication with the shaft guidewire lumen, the distal tip member having an inner layer formed of a first polymeric material having a first Shore durometer hardness which defines at least a section of the lumen of the distal tip, and an outer layer formed of a second polymeric material having a lower Shore durometer hardness than the first polymeric material and which is fusion bond compatible with the first polymeric material; andc) an inflatable balloon sealingly secured to the distal shaft section so that an interior of the balloon is in fluid communication with the shaft inflation lumen, formed at least in part of a polymeric material fusion bond compatible with the first and second polymeric materials of the distal tip member, and having a distal skirt section fusion bonded to a proximal section of the distal tip member such that the proximal section of the tip member is a fused blend of the balloon distal skirt section and the inner and outer layers of the tip member.22. The balloon catheter of wherein the distal tip member has a distal section located distal to the fused proximal section of the tip member and the balloon distal skirt section claim 21 , such that the balloon distal skirt section surrounds the proximal fused section and not the distal section of the tip member.23. The balloon catheter of wherein the inner ...

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Номер записи: 45
21-03-2019 дата публикации

Methods, Medical Devices and Kits for Modifying the Luminal Profile of a Body Vessel

Номер: US20190083740A1
Автор: JR. John C., Sigmon, Surti Vihar
Принадлежит:

Methods of modifying the luminal profile of a body vessel are described. An example method comprises advancing a cannula out of the distal end of a catheter disposed within the lumen of a body vessel of an animal and toward a target site on the wall of the body vessel; passing contrast dye through the cannula toward the target site; simultaneously continuing the advancing and passing until the distal end of the cannula punctures the inner layer of the wall of the body vessel at the target site; and passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site. Medical devices, medical device assemblies, and kits are also described. 1. A method of modifying the luminal profile of a body vessel at a target site , comprising:passing a bulking agent through a cannula and into a space between connective tissue layers surrounding a wall of said body vessel at said target site, the bulking agent including a cross-linking agent.2. The method of claim 1 , wherein the bulking agent comprising a hydrogel.3. The method of claim 2 , wherein the hydrogel contains alginate.4. The method of claim 3 , wherein the hydrogel comprises between about 4% and about 30% alginate.5. The method of claim 3 , wherein the hydrogel comprises about 17.5% alginate.6. The method of claim 1 , wherein the bulking agent comprises about 17.5% alginate.7. The method of claim 1 , wherein the crosslinking agent comprises a salt.8. The method of claim 7 , wherein the crosslinking agent is selected from the group consisting of MgCl2 claim 7 , CaCl2 claim 7 , SrCl2 claim 7 , BaCl2 claim 7 , Al3SO4 claim 7 , BaSO4 claim 7 , CaCO3 claim 7 , ferric chloride claim 7 , and ferrous chloride.9. The method of claim 7 , wherein the crosslinking agent comprises SrCl2.10. The method of claim 7 , wherein the crosslinking agent has a concentration of between about 0.05 Molar and about 4.00 Molar.11. The method of claim 7 , wherein the ...

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Номер записи: 46
19-03-2020 дата публикации

Methods, Medical Devices and Kits for Modifying the Luminal Profile of a Body Vessel

Номер: US20200086079A1
Автор: JR. John C., Sigmon, Surti Vihar
Принадлежит: Cook Medical Technologies LLC

Methods of modifying the luminal profile of a body vessel are described. An example method comprises advancing a cannula out of the distal end of a catheter disposed within the lumen of a body vessel of an animal and toward a target site on the wall of the body vessel; passing contrast dye through the cannula toward the target site; simultaneously continuing the advancing and passing until the distal end of the cannula punctures the inner layer of the wall of the body vessel at the target site; and passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site. Medical devices, medical device assemblies, and kits are also described. 1. A method of modifying the luminal profile of a body vessel at a target site , comprising:passing a bulking agent through a cannula and into a space between connective tissue layers surrounding a wall of said body vessel at said target site; andpassing a cross-linking agent through a cannula and into the space between connective tissue layers surrounding the wall of said body vessel at said target site.2. The method of claim 1 , wherein the bulking agent comprising a hydrogel.3. The method of claim 2 , wherein the hydrogel contains alginate.4. The method of claim 3 , wherein the hydrogel comprises between about 4% and about 30% alginate.5. The method of claim 3 , wherein the hydrogel comprises about 17.5% alginate.6. The method of claim 1 , wherein the bulking agent comprises about 17.5% alginate.7. The method of claim 1 , wherein the crosslinking agent comprises a salt.8. The method of claim 7 , wherein the crosslinking agent is selected from the group consisting of MgCl2 claim 7 , CaCl2 claim 7 , SrCl2 claim 7 , BaCl2 claim 7 , Al3SO4 claim 7 , BaSO4 claim 7 , CaCO3 claim 7 , ferric chloride claim 7 , and ferrous chloride.9. The method of claim 7 , wherein the crosslinking agent comprises SrCl2.10. The method of claim 7 , wherein the crosslinking agent has ...

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Номер записи: 47
19-06-2014 дата публикации

Systems and methods for reducing or preventing backflow in a delivery system

Номер: US20140171760A1
Автор: Deep Arjun Singh, Pj ANAND
Принадлежит: Alcyone Lifesciences Inc

Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.

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Номер записи: 48
19-06-2014 дата публикации

Systems and methods for reducing or preventing backflow in a delivery system

Номер: US20140171902A1
Автор: Deep Arjun Singh, Pj ANAND
Принадлежит: Alcyone Lifesciences Inc

Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.

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Номер записи: 49
07-04-2016 дата публикации

Delivery catheter systems and methods

Номер: US20160096001A1
Автор: Brian J. Perszyk, Matt Glimsdale, Thomas B. Eby, Tracee Eidenschink
Принадлежит: Pacesetter Inc

Disclosed herein is a delivery catheter for implanting a leadless biostimulator. The delivery catheter includes a shaft and a tubular body having a lumen and an atraumatic end. The atraumatic end includes at least one of a braided, woven or mesh construction configured to facilitate the atraumatic end changing diameter. When a distal portion of the shaft is coupled to a proximal region of the leadless biostimulator, at least one of distally displacing the tubular body relative to the shaft or proximally displacing the shaft relative to the tubular body causes the leadless biostimulator to be received in the volume of the atraumatic end and the atraumatic end to encompass the leadless biostimulator. Conversely, at least one of proximally displacing the tubular body relative to the shaft or distally displacing the shaft relative to the tubular body causes the leadless biostimulator to exit the volume of the atraumatic end.

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Номер записи: 50
05-04-2018 дата публикации

Flash Activated Passive Shielding Needle Assembly

Номер: US20180092585A1
Автор: Hwang Charles G., Wilkinson Bradley M.
Принадлежит:

A safety needle device includes a housing including a passageway with a needle cannula extending therefrom. A shielding member is movable between a first position in which a puncture tip of the needle cannula is exposed therefrom and a second position in which the puncture tip of the needle cannula is encompassed therein. The shielding member is maintained in the first position against a biasing force which biases the shielding member toward the second position. A fluid and/or a temperature activation material is associated with the shielding member and is adapted to deform upon contact with a fluid medium and/or a certain temperature or temperature range. The fluid medium flowing through the needle cannula causes the fluid activation material to deform, such as through expansion, thereby releasing the shielding member from the first position and allowing a drive member to bias the shielding member toward the second position. 1. A needle assembly , comprising:a housing including a passageway extending therethrough and a needle cannula having a puncture tip extending from a forward end thereof;a shielding member movable with respect to the housing between a first position in which the puncture tip of the needle cannula is exposed and a second position in which the puncture tip of the needle cannula is shielded by the shielding member, the shielding member maintained in the first position against a biasing force provided by a drive member biasing the shielding member toward the second position;an activation material associated with the shielding member and adapted to deform upon direct contact with a fluid flowing through the passageway of the housing; anda movable actuator located within the passageway,wherein the fluid flowing through the passageway of the housing causes the activation material to deform and cause the actuator to move, thereby releasing the shielding member from the first position and causing the drive member to bias the shielding member toward the ...

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Номер записи: 51
05-04-2018 дата публикации

APPARATUS FOR DELIVERING FLUID TO TREAT RENAL HYPERTENSION

Номер: US20180093075A1
Автор: JR. James F., McGuckin
Принадлежит: Rex Medical, L.P.

A surgical apparatus for delivering fluid to treat renal hypertension including an elongated member having a distal tip and a plurality of openings formed in a sidewall proximal of the distal tip. A plurality of fluid delivery members are movably positioned in the elongated member, each of the fluid delivery members having a lumen and at least one opening communicating with the lumen for delivering fluid extravascularly. An actuator is operatively associated with the fluid delivery members, the actuator actuable to a first position to move the fluid delivery members from a retracted position within the elongated member to a deployed position extending radially with respect to the elongated member. A balloon is expandable radially from the elongated member to seal the renal artery during application of fluid through the fluid delivery members. 112-. (canceled)13. A method for treating renal hypertension comprising:inserting an apparatus intravascularly over a guidewire to access the renal artery, the apparatus including a flexible elongated member;inflating a balloon to seal off the renal artery;advancing an actuator in a first direction to deploy a plurality of tines radially through side openings in the elongated member so the tines penetrate a wall of the artery; andinjecting fluid through a lumen in the tines and through a plurality of side openings in the tines to apply ablation fluid intravascularly for treating renal hypertension;wherein the apparatus includes a centering structure positioned proximal of the balloon and the method further includes the step of expanding the centering structure.14. The method of claim 13 , wherein the plurality of tines are composed of shape memory material.15. The method of claim 13 , wherein a distal tip of the tines does not extend distally of a distal tip of the apparatus.16. The method of claim 13 , wherein advancing the actuator advances the tines to exit proximally of the balloon.17. (canceled)18. The method of claim 13 , ...

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Номер записи: 52
05-04-2018 дата публикации

CATHETERS, CATHETER SYSTEMS, AND METHODS FOR PUNCTURING THROUGH A TISSUE STRUCTURE AND ABLATING A TISSUE REGION

Номер: US20180093088A1
Автор: Mickelsen Steven Richard
Принадлежит:

A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can include two catheters that are operatively coupled to one another by magnetic coupling through a tissue structure. The ablation catheter can include electrodes positioned within a central portion. The ablation catheter is positioned such that the central portion of a flexible shaft at least partially surrounds the selected tissue region. Each electrode of the ablation catheter can be activated independently to apply ablative energy to the selected tissue region. The ablation catheter can employ high impedance structures to change the current density at specific points. Methods of puncturing through a tissue structure using the percutaneous catheter system are disclosed. Also disclosed are methods for ablating a selected tissue region using the ablation catheter. 1. A method , comprising:positioning a catheter external to a heart of a subject, such that a central portion of the catheter at least partially encircles the left pulmonary veins and the right pulmonary veins of the heart, the central portion of the catheter including a set of electrodes; anddelivering electrical energy to at least a portion of the left atrium of the heart using two or more electrodes of the set of electrodes, the portion of the left atrium including: a first wall portion of the left atrium; the endocardial space of the left atrium; and a second wall portion of the left atrium.2. The method of claim 1 , the delivering the electrical energy including ablating tissue in the first wall portion and the second wall portion of the left atrium to create a lesion.3. The method of claim 1 , the delivering the electrical energy including ablating tissue in the portion of the left atrium to create a circumferential lesion in the wall of the left atrium without repositioning the catheter.4. The method of claim 1 , ...

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Номер записи: 53
12-05-2022 дата публикации

MEDICAL INSTRUMENT WITH INJECTION NEEDLES

Номер: US20220143364A1
Автор: Mariller Alain
Принадлежит:

The invention concerns an instrument, for a medical application, said instrument comprising a body (), at least one needle, channel means () to bring a fluid to said at least one needle, and actuating means () for moving said at least one needle from a retracted position to an extended position by rotation of actuating means () with respect to the body. 113-. (canceled)14. An instrument for a medical application comprising:a body;a needle;a channel fluidically connected to the needle to bring a fluid to the needle; andan actuator for moving the needle between a retracted position inside the body and an extended position protruding from the body, the moving performed by a rotation of the actuator relative to the body.15. The instrument according to claim 14 , wherein the movement of the needle from the retracted position to the extended position and vice versa is rectilinear.16. The instrument according to claim 14 , wherein the actuator includes a shaft configured to rotate inside the body claim 14 , the shaft including a first set of teeth.17. The instrument according to claim 16 , wherein the needle includes a support element having a second set of teeth.18. The instrument according to claim 16 , wherein the first set of teeth are circularly arranged around the shaft.19. The instrument according to claim 17 , wherein the first set of teeth of the shaft and the second set of teeth of the support element have the same pitch claim 17 , and are configured to cooperate with each other.20. The instrument according to claim 14 , wherein the instrument includes at least three needles.21. The instrument according to claim 14 , wherein the channel is flexible to flex upon a movement of the needle by the actuator.22. The instrument according to claim 14 , further comprising:a locking device to lock a position of the actuator in the retracted position and in the extended position.23. A method of using an instrument as defined in claim 14 , the method comprising the steps of: ...

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Номер записи: 54
28-03-2019 дата публикации

MEDICAL PUNCTURE NEEDLE

Номер: US20190091415A1
Автор: UEDA Takehiko
Принадлежит: TERUMO KABUSHIKI KAISHA

A medical puncture needle comprising includes: a rod-shaped body portion; and a blade surface formed at a distal end portion of the rod-shaped body portion. The blade surface includes: a first blade surface portion that is inclined with respect to a central axis of the body portion and extends to a tip, and a second blade surface portion that is formed on a back side of the first blade surface portion. A blade edge extending to the tip is formed by a ridgeline at which the first blade surface portion intersects the second blade surface portion. The second blade surface portion comprises a first plane and a second plane having different angles with respect to a virtual plane including the central axis passing through the tip at an orthogonal cross-section that is orthogonal to the central axis. 1. A medical puncture needle comprising:a rod-shaped body portion; anda blade surface formed at a distal end portion of the rod-shaped body portion; wherein: a first blade surface portion that is inclined with respect to a central axis of the body portion and extends to a tip, and', 'a second blade surface portion that is formed on a back side of the first blade surface portion,', 'wherein a blade edge extending to the tip is formed by a ridgeline at which the first blade surface portion intersects the second blade surface portion;, 'the blade surface comprisesthe second blade surface portion comprises a first plane and a second plane having different angles with respect to a virtual plane including the central axis passing through the tip at an orthogonal cross-section that is orthogonal to the central axis;the second plane is at a position farther from the tip than the first plane in a distal end view of the blade surface as viewed from a tip side along a central axis direction; andthe angle of the second plane with respect to the virtual plane in the orthogonal cross-section is smaller than the angle of the first plane with respect to the virtual plane in the orthogonal ...

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Номер записи: 55
12-04-2018 дата публикации

CATHETER DEVICE WITH NEEDLE GUARD

Номер: US20180099123A1
Автор: Woehr Kevin
Принадлежит: B. Braun Melsungen AG.

The present disclosure relates to a catheter device comprising a catheter hub in which a valve member is disposed, a needle fixed in a needle hub, the needle extending through the valve member in the catheter hub in a ready position, and a tubular receptacle in which the needle hub is displaceably guided and biased by a spring in a proximal direction relative to the receptacle, wherein the needle hub is releasably held in the ready position in the receptacle against the force of the spring by frictional force between needle circumference and catheter or catheter hub, which frictional force is reduced on retraction of the needle through the catheter hub such that the force of the spring prevails. 117-. (canceled)18. A catheter device comprising:a catheter hub having a body having a catheter tube attached to the body and extending in a distal direction, said body defining an interior;a valve member disposed in the interior of the catheter hub, said valve member having a wall with a proximally facing wall surface, a distally facing wall surface, and a plurality of slits formed through the wall and defining resilient lugs;a needle fixed to a needle hub, the needle having a needle tip and a needle shaft extending through the valve member and the catheter hub with the needle tip extending out a distal tip of the catheter tube in a ready position;a tubular receptacle having a body defining an interior in which the needle hub is disposed, said needle hub is releasably held against a spring force of a spring in the ready position and the needle hub is displaceably guided by the spring in a proximal direction when the spring is released; andwherein the spring is held in a compressed state by a releaseable locking member located at a distal end of the tubular receptacle when in the ready position, said releaseable locking member having a surface for pressing by a user.19. The catheter device according to claim 18 , wherein the valve member has at least three slits forming the ...

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Номер записи: 56
08-04-2021 дата публикации

EXTENSION TUBE ASSEMBLY AND RELATED MEDICAL FLUID TRANSFER SYSTEMS AND METHODS

Номер: US20210100977A1
Автор: Piferi Peter G.
Принадлежит:

Devices for transferring fluid to or from a subject include an extension tube assembly with an axially extending inner tube configured to couple to an elongate tubular cannula having opposing proximal and distal ends with an axially extending lumen and an axially extending inner tube. The inner tube extending through the tubular cannula defines an exposed needle tip and is in fluid communication with the inner tube of the extension tube assembly. The needle tip extends out of a distal end of the tubular cannula a suitable distance. 1. A medical extension tube assembly for transferring fluid to or from a subject , comprising:an outer support tube having an inner lumen and a length and opposing first and second end portions;an inner tube longitudinally extending inside the inner lumen of the outer support tube and defining a longitudinally extending open fluid flow path;a first connector coupled to the first end portion of the outer support tube; anda second connector coupled to the second end portion of the outer support tube, wherein the inner tube has an inner diameter in a range of about 100 μm and about 750 μm, wherein the inner tube extends out of the first end portion of the outer support sleeve into the first connector, and wherein the inner tube extends out of the second end portion of the outer support sleeve into the second connector.2. The medical extension tube assembly of claim 1 , further comprising a solid filler material residing in the inner lumen of the outer support tube and surrounding the inner tube at the first and second end portions claim 1 , wherein the filler material extends a distance into the first connector and a distance into the second connector.3. The medical extension tube assembly of claim 2 , wherein the inner lumen of the outer support tube defines an open gap space surrounding the inner tube along a sub-length of the length of the outer support tube between the opposing first and second end portions.4. The medical extension tube ...

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Номер записи: 57
13-04-2017 дата публикации

METHODS AND SYSTEMS FOR TREATMENT OF A BLADDER

Номер: US20170100565A1
Автор: BORZELLECA David C., NAGALE Sandra, Weiser Michael F.
Принадлежит: BOSTON SCIENTIFIC SCIMED, INC.

A medical device is disclosed. The medical device may include an elongate member having a proximal end and a distal end an expandable end effector assembly extending distally from the distal end of the elongate member. The end effector assembly may include a plurality of end effector units each having an injector for simultaneously delivering material into tissue. 120-. (canceled)21. A device for treating a bladder , comprising:a shaft having a proximal end, a distal end, and one or more lumens;a spherical end effector assembly extending distally from the distal end of the shaft, the end effector assembly defining a plurality of apertures, wherein each aperture is in communication with a corresponding lumen of the shaft; andan injection unit positioned in each aperture of the end effector assembly to direct delivery of material from the end effector assembly; a frame;', 'an injector; and', 'a dispenser., 'wherein each injection unit includes22. The device of claim 21 , wherein the frame further comprises:a first arm; anda second arm,wherein the second arm is pivotably connected to the first arm via a pivot.23. The device of claim 22 , wherein the injector is fixed to a surface of the first arm and extends perpendicular to the first arm.24. The device of claim 23 , wherein the injector is a needle having at least a curved portion claim 23 , a distal point claim 23 , and a hollow interior.25. The device of claim 24 , wherein the needle is a microneedle.26. The device of claim 22 , wherein the dispenser is mounted on the first arm opposite to the injector.27. The device of claim 26 , wherein the dispenser is in fluid communication with the injector via an aperture in the first arm.28. The device of claim 26 , wherein the dispenser is an elastomeric fluid container.29. The device of claim 21 , further comprising an actuation mechanism.30. An injection unit claim 21 , comprising:a frame having at least a first arm and a second arm coupled via a pivot;an injector fixed on ...

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Номер записи: 58
09-06-2022 дата публикации

DELIVERY DEVICES AND METHODS FOR LEADLESS CARDIAC DEVICES

Номер: US20220176110A1
Автор: Haasl Benjamin J., Schmidt Brian L.
Принадлежит: Cardiac Pacemakers, Inc.

Delivery devices, systems, and methods for delivering implantable leadless pacing devices are disclosed. An example delivery device may include a proximal section including a deflection mechanism for deflecting the proximal section, and a distal holding section extending distally of a distal end of the proximal section and defining a cavity therein for receiving an implantable leadless pacing device. The distal holding section may be structured to have portions that flex and bend while allowing the implantable device to be recaptured within the distal holding section. 1. A delivery device for delivering an implantable leadless pacing device , the delivery device comprising:a proximal elongate shaft having an outer diameter;a distal holding section extending distally of a distal end of the proximal elongate shaft, the distal holding section having an outer diameter greater than the outer diameter of the proximal elongate shaft, the distal holding section defining a cavity therein for receiving an implantable leadless pacing device; andwherein the distal holding section comprises a predefined curved portion along a length thereof such that a central axis of the distal holding section is curved.2. The delivery device of claim 1 , wherein the distal holding section straightens such that the central axis of the distal holding section extends generally parallel to a longitudinal axis of the proximal section when an implantable leadless pacing device is disposed within the cavity.3. The delivery device of claim 1 , wherein the distal holding section comprises a shape memory polymer.4. The delivery device of claim 1 , wherein the distal holding section includes a body portion and a distal tip claim 1 , the distal tip being made of a material having a lower durometer than a material forming the body portion.5. The delivery device of claim 1 , wherein the distal holding section incudes multiple layers claim 1 , with an inner layer made of a material that is harder than an ...

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Номер записи: 59
25-04-2019 дата публикации

INTRAVASCULAR FLUID CATHETER WITH MINIMAL INTERNAL FLUID VOLUME

Номер: US20190117936A9
Автор: FISCHELL DAVID R., FISCHELL TIM A.
Принадлежит: ABLATIVE SOLUTIONS, INC.

A catheter-based/intravascular ablation (denervation) system includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic or/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable needle delivery system is formed with self-expanding materials and include structures, near the end portion of the needles, or using separate guide tubes. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel. The preferred embodiment of the catheter delivered through the vascular system of a patient includes a multiplicity of expandable guide tubes that engage the wall of a blood vessel. Injection needles having injection egress at or near their sharpened distal end are then advanced through the guide tubes to penetrate the wall of the blood vessel to a prescribed depth. The ability to provide PeriVascular injection so as to only affect the outer layer(s) of a blood vessel without affecting the media has particular application for PeriVascular Renal Denervation (PVRD) of the sympathetic nerves which lie in the adventitia or outside the adventitia of the renal artery. 172-. (canceled)73. A percutaneously delivered system for peri-vascular fluid delivery comprising:a fluid delivery catheter having a proximal control portion, a central catheter body, a distal fluid delivery portion;the distal fluid delivery portion including 2 or more injection needles having lumens, the injection needles having injection egress near their distal ends, the needles further adapted to move radially outward to penetrate the wall of a target vessel to position the injection egress at a pre-set depth with respect to the inner wall of the target ...

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Номер записи: 60
12-05-2016 дата публикации

MEDICAL DEVICE HAVING AN ATRAUMATIC DISTAL TIP

Номер: US20160129221A1
Автор: GROFF JOEL N., Haverkost Patrick A., JR. Anthony F., Tassoni, Willard Martin R.
Принадлежит: BOSTON SCIENTIFIC SCIMED, INC.

A delivery catheter includes a soft, atraumatic distal tip. The distal tip is configured to transition from a folded configuration to an unfolded configuration during delivery of a medical device. A wall thickness of the distal tip may be increased such that the distal tip is biased to remain in the unfolded configuration after delivery. Additionally, the increased wall thickness in a selected region of the distal tip may cause the distal tip to resist and/or prevent collapse of the distal tip during retrieval and/or repositioning of the medical device when the medical device comes into contact with a distal end of the catheter. The distal edge of the distal tip may be rounded so as to prevent the distal tip from damaging tissue during advancement of the catheter to a target location within a patient's body.

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Номер записи: 61
03-06-2021 дата публикации

URINARY CATHETER HAVING A SOFT TIP

Номер: US20210162172A1
Автор: Dahlberg Niklas, Nyman Martin
Принадлежит:

A urinary catheter is disclosed, comprising a tubular shaft extending between an insertable end and a discharge end, and a tip fixedly connected to said insertable end of the tubular shaft. The tip has an outer diameter which at all places is equal to or lower than the outer diameter of the tubular shaft, and is very soft, so that the hardness of the tip is equal to or lower than 60 micro Shore A. It has been found that such a soft tip provides a catheter which is easier to insert into the urethra, in particular in urethras providing various types of obstacles. A corresponding method of manufacturing is also disclosed. 126-. (canceled)27. A urinary catheter comprising a tubular shaft extending between an insertable end and a discharge end , and a tip fixedly connected to said insertable end of the tubular shaft , wherein said tip is solid and has an outer diameter which at all places is equal to or smaller than the outer diameter of the tubular shaft , and comprises a part tapering in a direction away from the tubular shaft , and a rounded end part , and wherein a hardness of the tip is within the range 20-60 micro Shore A and the tip has a micro Shore A hardness which is lower than the micro Shore A hardness of the tubular shaft , wherein the urinary catheter is a hydrophilic urinary catheter with a single lumen.28. The urinary catheter of claim 27 , wherein the tip is curved and angled upwards.29. The urinary catheter of claim 27 , wherein the hardness of the tip is equal to or lower than 50 micro Shore A.30. The urinary catheter of claim 27 , wherein the hardness of the tip is equal to or lower than 45 micro Shore A.31. The urinary catheter of claim 27 , wherein the hydrophilic urinary catheter is at least partly provided with a hydrophilic surface coating claim 27 , said hydrophilic surface coating exhibiting a reduced friction when wetted32. The urinary catheter of claim 27 , wherein the hydrophilic urinary catheter is made of a hydrophilic material.33. The ...

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Номер записи: 62
17-05-2018 дата публикации

METHODS AND MATERIALS FOR DELIVERING AGENTS TO LIVER TISSUE

Номер: US20180133159A1
Автор: FAIGEL Douglas O.
Принадлежит: Mayo Foundation for Medical Education and Research

This document provides methods and materials for delivering agents to liver tissue. For example, methods and materials for using microbeads to deliver agents (e.g., chemotherapeutic agents) to liver tissue are provided. 1. A method for delivering an agent to liver tissue , wherein said method comprises:(a) advancing an endoscope device configured with a needle into the stomach or duodenum of a mammal under endoscopic ultrasound guidance,(b) advancing said needle out of said stomach or duodenum and into a portal vein of said mammal, and(c) administering a solution containing said agent into said portal vein,wherein the concentration of said agent within liver tissue of said mammal following said administering step is greater than the concentration of said agent within liver tissue when the same amount of said agent is administered to the jugular vein of a control mammal.2. The method of claim 1 , wherein said mammal is a human.3. The method of claim 1 , wherein said agent is irinotecan claim 1 , doxorubicin claim 1 , or paclitaxel.4. The method of claim 1 , wherein said solution comprises said agent loaded onto microbeads having a diameter between about 75 μm and about 700 μm.5. The method of claim 4 , wherein the concentration of said agent within plasma of said mammal 30 minutes following said administering step is less than the concentration of said agent within plasma 30 minutes after the same amount of said agent is administered to the jugular vein of a control mammal without microbeads.6. The method of claim 1 , wherein said solution is administered to said portal vein through said needle.7. The method of claim 1 , wherein said endoscope device comprises a catheter.8. The method of claim 7 , wherein said catheter is advanced over said needle into said portal vein claim 7 , wherein said needle is removed from said portal vein claim 7 , and wherein said solution is administered to said portal vein through said catheter.9. The method of claim 7 , wherein said ...

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Номер записи: 63
08-09-2022 дата публикации

Catheter

Номер: US20220280746A1
Автор: Wiesman Jon
Принадлежит: Wiesconcepts, LLC

A catheter assembly having the major components: a cap, an introducer tip, four different variations of grip housing, a tube gripper and a catheter. The variations of the housing connected to the catheter assembly allows for safe and effective delivery of the anesthetics to various bodily orifices. The catheter is slowly advanced further while irrigating and dispensing the medication and/or lidocaine gel from the syringe. Once the desired depth is reached the practitioner can mark off the depth in centimeters on the catheter using a variation of the marker. 1. A catheter assembly comprising:a catheter having at least one connection fitting at a proximal end thereof and at least one opening positioned a distal end positioned opposite the proximal end;a grip housing having a housing receiving passageway through which the catheter travels longitudinally there through, and a raised webbed grip positioned proximate an outer central region thereof;a tube gripper movably positioned at one end of the grip housing and having a catheter orifice for receiving the catheter; andan anesthetizing medicament device connected to the at least one connection fitting and provided with an anesthetizing medicament, the anesthetizing medicament being advanced by the anesthetizing medicament device through the catheter passage and exiting the at least one opening of the catheter.2. The catheter assembly of claim 1 , wherein the tube gripper includes a top face claim 1 , a bottom face claim 1 , and a gripping surface positioned between the top face and bottom face along the catheter orifice.3. The catheter assembly of claim 2 , wherein the tube gripper further includes a chamfered edge on the outer edge.4. The catheter assembly of claim 3 , wherein the tube gripper in a first position includes a portion of the top face making contact with the leveling surface such that a catheter orifice of the tube gripper is positioned substantially co-axial to the catheter passage.5. The catheter ...

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Номер записи: 64
30-04-2020 дата публикации

DEVICES FOR ASSISTING WITH ADVANCEMENT OF CATHETERS AND RELATED SYSTEMS AND METHODS

Номер: US20200129734A1
Автор: DI CAPRIO FERNANDO, Panarello Gianfranco
Принадлежит:

Disclosed herein is a catheter advancement device having an elongate shaft and a capsule attached to or integral with the shaft, and related methods for assisting with advancement of catheters such as cardiovascular guiding catheters while reducing damage to the inner wall of the blood vessel. Some capsules have a distal plug portion and a neck portion having a smaller diameter than the plug. Other capsules have a channel defined along the outer surface of the capsule. Some elongate shafts have an attachment tube disposed at or near the proximal end thereof. 1. A catheter advancement assistance device , the device comprising:(a) an elongate shaft; (i) a guidewire lumen defined through the capsule;', '(ii) an outer diameter substantially similar to an inner diameter of a catheter such that the capsule is sized to be positionable through the catheter; and, '(b) a capsule fixedly attached to a distal end of the elongate shaft, the capsule comprising(c) an attachment tube associated with a proximal portion of the elongate shaft.2. The device of claim 1 , wherein the attachment tube further comprises:(a) a tube body;(b) a lumen defined within the tube body;(c) a distal opening defined in a distal end of the tube body, wherein the distal opening is in fluidic communication with the lumen; and(d) a proximal opening defined in a proximal end of the tube body, wherein the proximal opening is in fluidic communication with the lumen.3. The device of claim 1 , wherein the attachment tube is a compressible attachment tube.4. The device of claim 3 , wherein the compressible attachment tube comprises an elongate opening defined along a length of the compressible attachment tube.5. The device of claim 1 , wherein the capsule further comprises:(a) a distal portion; and(b) a neck extending proximally from the distal portion, wherein the neck has a smaller diameter than the distal portion.6. The device of claim 1 , wherein the guidewire lumen has an inner diameter that is larger than ...

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Номер записи: 65
07-08-2014 дата публикации

Angled Tip Catheter

Номер: US20140221979A1
Автор: Vreeman Daniel J.
Принадлежит: COVIDIEN LP

A catheter having improved ability to cross body passage obstructions and that more easily allows backloading of a guidewire into the lumen of the catheter is comprised of a tip, a shaft, and a lumen. The distal end of the catheter tip is oriented at an angle other than 90° to the lengthwise axis of the catheter tip. A guidewire may be easily backloaded into the elongated catheter lumen at the location of the angled catheter tip. 132-. (canceled)33. A catheter comprising:an elongate shaft having proximal and distal ends, a length extending between the proximal and distal ends, a distal tip having a lengthwise axis and defining the distal end of the shaft, a distal opening defined by the distal end of the shaft, and a lumen extending proximally from the distal opening through the proximal end of the shaft,wherein an entirety of the distal end of the shaft is oriented at an angle other than 90 degrees to the lengthwise axis of the distal tip, andwherein the shaft has a bend at least from the distal tip to a location that is 10 percent of the shaft length proximal from the distal tip.34. The catheter set forth in in combination with a guidewire having proximal and distal ends claim 33 , wherein the proximal end of the guidewire is insertable through the distal opening of the shaft and into the lumen and the shaft is advanceable along the guidewire.35. The catheter set forth in claim 34 , wherein the bend of the shaft has a maximum concavity claim 34 , and wherein the guidewire has a bend having a maximum convex curvature claim 34 , the shaft configured to self-orient on the guidewire as the shaft is advanced along the guidewire such that the maximum concavity of the bend of the shaft aligns with the maximum convex curvature of the guidewire.36. The catheter set forth in claim 35 , wherein the maximum concavity of the shaft is from 0.2 cm to 2 cm as measured over a length of 10 cm.37. The catheter set forth in claim 36 , wherein the maximum concavity of the shaft is one ...

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Номер записи: 66
04-06-2015 дата публикации

Devices And Methods For Renal Denervation

Номер: US20150151077A1
Автор: Harrington Douglas C.
Принадлежит:

Devices and methods that produce alterations of renal sympathetic nerve activity by use of tissue modifying implants. Devices for percutaneous delivery of implants into a renal artery or vein wall employing various needle assembly arrangements to modify renal nerve activity. 1. A method for renal denervation comprising creating a remodeled zone that spans a complete closed loop around a vessel carrying renal nerves.2. The method of wherein creating a remodeled zone comprises delivering a plurality of bioactive implants in proximity to renal nerves.3. The method of wherein delivering a plurality of bioactive implants in proximity to renal nerves comprises injecting a plurality of implants into tissue in proximity to renal nerves.4. The method of wherein injecting a plurality of implants into tissue in proximity to renal nerves comprises:navigating a catheter to a target site, said catheter carrying at least one flexible needle containing at least one of said implants;advancing said at least one needle from said catheter into said tissue;ejecting said implants from said at least one needle.5. The method of wherein ejecting said implants from said at least one needle comprises retracting said needle while maintaining a position of said implants relative to said tissue.6. The method of wherein advancing said at least one needle from said catheter into said tissue comprises advancing said at least one needle from said catheter at an outward angle from a longitudinal axis of said catheter.7. The method of wherein delivering a plurality of bioactive implants comprises delivering a plurality of bioactive implants claim 2 , each of said implants including a material selected from the group consisting of sclerosants claim 2 , neurotoxins claim 2 , polymers claim 2 , and metals.8. A device for use in renal denervation comprising:a catheter having a plurality of lumens;a needle contained within each lumen and moveable longitudinally relative to said catheter, each needle ...

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Номер записи: 67
14-08-2014 дата публикации

Drug Delivery Catheters That Attach To Tissue And Methods For Their Use

Номер: US20140228748A1
Автор: Altman Peter A., Hakim Brian K., Kayser Daniel J., Maston Robert E., McEtchin Douglas, Rosenman Daniel C.
Принадлежит: BioCardia, Inc.

A system and method for delivering a drug to a target site within a patient's body. The system and method include a steerable guide catheter and a drug delivery catheter. The steerable guide catheter has a first extension tube and a second extension tube that are joined together and form a shoulder. The delivery catheter has a distal docking segment and a proximal docking segment. The guide catheter is inserted into the patient's body, then the delivery catheter is inserted into the guide catheter. The distal docking segment engages the first extension tube, the proximal docking segment engages the second extension tube, and the shoulder limits the distance the delivery catheter can be inserted into the guide catheter. Also, once the delivery catheter is inserted it can be rotated to attach the helical tip to the target site. The guide catheter also includes a steering mechanism as well as a friction mechanism which controls the tension on the steering mechanism. The delivery catheter also includes two luer fittings, each having its own lumen. 1. A system for delivering a drug to a target site within a patient's body comprising: a guide catheter having a distal end, a proximal end and a longitudinal axis; and', 'a steering pullwire for deflecting the guide catheter;', 'a first handle, disposed at the proximal end of the guide catheter, said first handle having a control means operably connected to the steering pullwire; and, 'a steerable guide catheter comprising a second handle secured to the proximal end of the drug delivery catheter, said second handle disposed proximal to the first handle and having a longitudinal axis, a distal end, and a proximal end;', 'a delivery catheter having a lumen, said delivery catheter protruding out of the distal end of the second handle and aligned substantially along the longitudinal axis of the second handle and extensible beyond the distal end of the guide catheter;', 'a helical drug delivery needle operably connected to the ...

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Номер записи: 68
15-09-2022 дата публикации

Endovascular delivery systems with radial orientation mechanisms

Номер: US20220287860A1
Автор: Ruwan Sumanasinghe
Принадлежит: Cook Medical Technologies LLC

The present embodiments provide delivery systems for facilitating orientation of a prosthesis in a bodily passage. In one example, a system comprises an inner cannula having proximal and distal regions, and further comprises an atraumatic tip having a proximal end, a distal end, and a central region disposed therebetween. At least a portion of the atraumatic tip may be coupled to the proximal region of the inner cannula. A plurality of orientation struts are provided having a retracted delivery state, an expanded deployed state, and a retracted withdrawal state. The plurality of orientation struts each have apices that are oriented proximally relative to the atraumatic tip in the retracted delivery state, are oriented radially outward relative to the atraumatic tip in the expanded deployed state, and are oriented distally relative to the atraumatic tip in the retracted withdrawal state.

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Номер записи: 69
31-05-2018 дата публикации

INTRAVASCULAR DELIVERY OF NANOPARTICLE COMPOSITIONS AND USES THEREOF

Номер: US20180147139A1
Автор: Desai Neil P., SEWARD Kirk
Принадлежит:

The present invention provides methods of delivering a composition comprising nanoparticles that comprise a macrolide and an albumin by directly injecting the nanoparticle composition into the blood vessel wall or the tissue surrounding the blood vessel wall. The methods can be used for inhibiting negative remodeling or vascular fibrosis in the blood vessel and are useful for treating various diseases. 1. A method of inhibiting negative remodeling in a blood vessel in an individual in need thereof , comprising injecting into the blood vessel wall or tissue surrounding the blood vessel wall an effective amount of a composition comprising nanoparticles comprising a macrolide and an albumin.2. A method of delivering a composition comprising nanoparticles comprising albumin and a macrolide to a blood vessel , wherein the method comprises injecting into the blood vessel wall or tissue surrounding the blood vessel wall an effective amount of a composition comprising nanoparticles comprising a macrolide and an albumin.3. The method of claim 2 , wherein the blood vessel is an artery.4. The method of claim 2 , wherein the blood vessel is a vein.5. The method of claim 2 , wherein the nanoparticle composition is injected into the blood vessel wall.6. The method of claim 2 , wherein the nanoparticle composition is injected into the tissue surrounding the blood vessel wall.7. The method of claim 2 , wherein the nanoparticle composition is injected at a dose of about 0.001 mg to about 100 mg.8. The method of claim 2 , wherein the injection volume of the nanoparticle composition is about 0.01 ml to about 50 ml.9. The method of claim 2 , wherein the nanoparticle composition is injected though a catheter with a needle.10. The method of claim 2 , wherein the nanoparticle composition is injected at least once a year.11. The method of claim 2 , wherein the nanoparticle composition is injected distal or proximal to the disease site.12. The method of claim 2 , wherein the nanoparticle ...

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Номер записи: 70
11-06-2015 дата публикации

Methods for Treating Heart Arrhythmia

Номер: US20150157398A1
Автор: Denise Zarins, Hanson Gifford, III
Принадлежит: Medtronic Ardian Luxembourg SARL

Methods and apparatus are provided for treatment of heart arrhythmia via renal neuromodulation. Such neuromodulation may effectuate irreversible electroporation or electrofusion, ablation, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, such neuromodulation is achieved through application of an electric field. In some embodiments, such neuromodulation is achieved through application of neuromodulatory agents, of thermal energy and/or of high intensity focused ultrasound. In some embodiments, such neuromodulation is performed in a bilateral fashion.

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Номер записи: 71
01-06-2017 дата публикации

DOUBLE-LUMEN INFUSION CATHETER WITH INFUSION LUMEN WIDENED ALONG INTERMEDIATE SECTION THEREOF

Номер: US20170151384A1
Автор: Carmel Ilan, Shahrur Josef, TAL Michael Gabriel
Принадлежит: A.V. Medical Technologies LTD

Double-lumen infusion catheter including: a shaft having proximal section, distal section, and intermediate section therebetween; first and second lumens extending along a length of the shaft and having arc shaped wall therebetween; and an inflatable member provided distally to intermediate section, and over the distal section. First lumen has cross section larger than cross section of second lumen and is configured to receive a guidewire therethrough and allow fluid flow via an unobstructed portion of first lumen. Unobstructed portion is formed along guidewire outer surface, between guidewire outer surface and inner wall of first lumen, and extends from an inlet at proximal end of intermediate section to an outlet at distal end of intermediate section. First lumen is narrowed to approximate a first diameter in shaft proximal and distal sections, and is widened to approximate a second diameter greater than first diameter in the shaft intermediate section. 1. A double-lumen infusion catheter comprising:a shaft comprising a proximal section, a distal section, and an intermediate section therebetween;a first lumen and a second lumen extending along a length of said shaft and having an arc shaped wall therebetween; andan inflatable member provided distally to said intermediate section, and over said distal section;said first lumen has a cross section larger than a cross section of said second lumen and is configured to receive a guidewire therethrough and to allow fluid flow via an unobstructed portion of said first lumen, said unobstructed portion is formed along an outer surface of said guidewire, between said guidewire outer surface and an inner wall of said first lumen, and extends from an inlet at a proximal end of said intermediate section to an outlet at a distal end of said intermediate section;wherein said first lumen is narrowed to approximate a first diameter in said shaft proximal and distal sections, and is widened to approximate a second diameter greater ...

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Номер записи: 72
01-06-2017 дата публикации

Methods and Systems for Delivery of a Trail of a Therapeutic Substance into an Anatomical Space

Номер: US20170151416A1
Автор: Aimetti Alex A., Charles Robert, Collins Brendan P., Guest James D., Kutikov Artem B., Layer Richard T., Moore Simon W., Taylor Jon, Ulich Thomas R., Zeleny Eugene
Принадлежит:

Injection devices and methods for delivering a trail of therapeutic cells and/or one or more therapeutic substances or diagnostic substances or injectable medium into an anatomical space of an animal or human subject, particularly a trail of therapeutic cells and/or one or more therapeutic substances or diagnostic substances or injectable medium into the spinal cord of a subject and to deliver a trail of therapeutic cells and/or one or more therapeutic substances or diagnostic substances or injectable medium inside the spinal cord, to treat an injury or disorder of the central nervous system requiring injection of cells and/or one more therapeutic substances. The devices and methods are useful for the treatment of a variety of traumas, conditions and diseases, in particular, spinal cord injuries, amyotrophic lateral sclerosis, multiple sclerosis and spinal ischemia as well as other spinal cord degenerative conditions and pathologies. 1. An injection system for delivering an injectable medium into an anatomical space of an animal or human subject , the system comprising:a first linear actuator;a syringe comprising a catheter connection at one end and a plunger attached to a plunger rod at a second end, wherein the syringe contains an injectable medium for injection into an anatomical space of an animal or human subject;a delivery catheter having a proximal and distal end, wherein the distal end is configured to enter the anatomical space of a subject, and wherein the proximal end is attached to the catheter connection of the syringe;a guide tube having a proximal end and a distal end, wherein the guide tube is configured to house a portion of the distal end of the delivery catheter; further wherein the proximal end of the guide tube is connected to a guide tube holder;a stereotaxic assembly connected to the guide tube holder, thereby allowing spatial adjustments along the x, y and z-axes; wherein the stereotaxic positioning assembly is configured to move the distal ...

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Номер записи: 73
22-09-2022 дата публикации

ISOLATION AND ATTACHMENT CATHETERS AND METHODS FOR USING THEM

Номер: US20220296853A1
Автор: Eversull Christian S., Leeflang Stephen A.
Принадлежит:

Systems and methods are provided for navigating within the heart and attaching to the wall of the heart for performing injection of one or more agents into tissue. The system includes an outer catheter, a mid catheter slidably disposed within a lumen of the outer catheter, and a needle catheter slidably disposed within a lumen of the mid catheter. The mid catheter includes a vacuum hood attached to a mid catheter distal end such that a radiopaque distal tip of the mid catheter extends into the vacuum hood. The vacuum hood includes at least two radiopaque features, the spatial relationship of which visibly changes under fluoroscopy when the vacuum hood is under sealed vacuum. 1. A system for injecting one or more agents into tissue within a patient's body , comprising:a first tubular member comprising a proximal end, a distal end sized for introduction into a patient's body, and a lumen extending between the proximal and distal ends;a second tubular member comprising a proximal end, a distal end sized for introduction into a patient's body, and a lumen extending between the proximal and distal ends, the second tubular member slidably disposed in the lumen of the first tubular member;a needle catheter slidably disposed in the lumen of the second tubular member; anda vacuum hood attached to the distal end of the second tubular member, the second tubular member comprising a radiopaque distal tip extending at least partially into the vacuum hood, and the vacuum hood having at least two radiopaque features, the spatial relationship of which visibly changes under fluoroscopy when the vacuum hood is under sealed vacuum.2. The system of claim 1 , wherein the vacuum hood comprises a proximal end attached to the second tubular member distal end proximal to the distal tip and a distal face shaped for contacting a tissue surface within a patient's body.3. The system of claim 2 , wherein the vacuum hood includes one or more annular features between the vacuum hood proximal end ...

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Номер записи: 74
08-06-2017 дата публикации

INTRAVASCULAR DELIVERY OF NANOPARTICLE COMPOSITIONS AND USES THEREOF

Номер: US20170157035A1
Автор: Desai Neil P., SEWARD Kirk
Принадлежит:

The present invention provides methods of delivering a composition comprising nanoparticles that comprise a macrolide and an albumin by directly injecting the nanoparticle composition into the blood vessel wall or the tissue surrounding the blood vessel wall. The methods can be used for inhibiting negative remodeling or vascular fibrosis in the blood vessel and are useful for treating various diseases. 1. (canceled)2. A method of inhibiting vascular fibrosis in a blood vessel in an individual in need thereof , comprising injecting into the blood vessel wall or tissue surrounding the blood vessel wall an effective amount of a composition comprising nanoparticles comprising a macrolide and an albumin.3. The method of claim 2 , wherein the vascular fibrosis is medial vascular fibrosis or adventitial fibrosis.4. A method of promoting positive remodeling in a blood vessel in an individual in need thereof claim 2 , comprising injecting into the blood vessel wall or tissue surrounding the blood vessel wall an effective amount of a composition comprising nanoparticles comprising a macrolide and an albumin.5. The method of claim 2 , wherein the blood vessel is an artery.6. The method of claim 5 , wherein the artery is a coronary artery or a peripheral artery.7. The method of claim 5 , wherein the artery is selected from the group consisting of renal artery claim 5 , cerebral artery claim 5 , pulmonary artery claim 5 , and artery in the leg.8. (canceled)9. The method of claim 2 , wherein the nanoparticle composition is injected into the blood vessel wall.10. The method of claim 2 , wherein the nanoparticle composition is injected into the tissue surrounding the blood vessel wall.11. The method of claim 10 , wherein the nanoparticle composition is injected into the adventitial tissue of the blood vessel.12. The method of claim 2 , wherein the nanoparticle composition is injected at a dose of about 0.001 mg to about 100 mg.13. The method of claim 12 , where the nanoparticle ...

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Номер записи: 75
14-05-2020 дата публикации

Ultrasonic catheter for renal denervation

Номер: US20200147276A1
Автор: Benjamin J. Clark, Sowmya G. Ballakur
Принадлежит: Medtronic Ardian Luxembourg SARL

Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device including a therapeutic assembly having a PVDF transducer. A method for tissue denervation through the application of ultrasonic energy, can include positioning a PVDF transducer within a blood vessel of a patient; applying RF energy to the PVDF transducer thereby causing the PVDF transducer to deliver ultrasonic energy to the tissue; and at least partially denervating tissue that is innervated by neural matter located within or in proximity to the blood vessel via the ultrasonic energy delivered to the tissue.

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Номер записи: 76
14-05-2020 дата публикации

INTRABODY SURGICAL FLUID TRANSFER ASSEMBLIES WITH ADJUSTABLE EXPOSED CANNULA TO NEEDLE TIP LENGTH, RELATED SYSTEMS AND METHODS

Номер: US20200147344A1
Автор: Flores Jesse, Piferi Peter G.
Принадлежит:

Devices for transferring fluid to or from a subject include an elongate tubular cannula having opposing proximal and distal ends with an axially extending lumen. The devices also include an elongate needle having opposing proximal and distal ends. The elongate needle is configured so that the distal end of the needle extends out of the distal end of the cannula a suitable adjustable distance. The devices also include a housing with a length adjustment mechanism that adjusts a length between the tip of the needle and the distal end of the tubular cannula. 1. A surgical assembly for transferring fluid to or from a subject , comprising:a tubular cannula having opposing proximal and distal ends with an open axially extending lumen;a needle that is elongate and has opposing proximal and distal ends, wherein a length of the needle extends through the tubular cannula lumen so that the distal end of the needle with a tip extends out of the distal end of the distal end of the tubular cannula to provide an exposed tip of the needle;a housing comprising opposing proximal and distal ends, wherein the housing holds the tubular cannula with the needle with the tubular cannula and needle extending out of the distal end of the housing, and wherein the housing comprises a rotatable outer wall; andan internal screw in the housing cooperably engaged with the rotatable outer wall,wherein, in response to rotation of the outer wall of the housing, the internal screw longitudinally translates to adjust a length between the distal end of the tubular cannula and the exposed tip of the needle.2. The assembly of claim 1 , wherein the housing has a length from about 1 inch to about 6 inches.3. The assembly of claim 1 , wherein the needle has a stroke distance of between about 0.5 inches and 3 inches and has a proximal end that resides inside the housing.4. The assembly of claim 1 , wherein the needle has a stroke distance of between about 0.5 inches and 3 inches and has a proximal end that ...

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Номер записи: 77
24-06-2021 дата публикации

Injection Device and Method

Номер: US20210187207A1
Автор: Bapat Shalaka V., McDonald Michael B.
Принадлежит:

An injection device is used for “tattooing” markers inside the heart of a patient at specific locations. Placement within the heart of markers, such as points marked with a radiopaque dye, may reduce the use of x-ray dye and echocardiography, may allow a quicker cardiac procedure, and thus may improve the procedure outcome for the patient. Alternatively or additionally to cardiac marking with a radiopaque dye, cardiac tissue fibrosis, cardiac tissue contraction, and/or cardiac tissue stiffening (or hardening) can be promoted at specific locations by delivering a suitable substance. 1. A surgical device for injecting a substance into tissue of a patient , comprising:an injector device including a mechanism to hinder ejection flow of the fluid to be injected between successive ejections;a tube having a proximal end connected to the injector device and a distal end; andone or more needles that protrude from the distal end of the tube,wherein the distal end of the tube is sealed around the one or more needles.2. The surgical device of claim 1 , wherein the injector device comprises:a barrel for containing the fluid to be injected;a plunger slidable inside the barrel for applying pressure to the fluid being injected;a rod connected to the plunger and extending from the barrel; and3. The surgical device of claim 2 , wherein mechanism to hinder ejection flow of the fluid to be injected between successive ejections comprises one or more of a valve and a trigger capable of releasing a ratchet mechanism used to lock the plunger position4. The surgical device of claim 1 , wherein the tube has a dual lumen configuration.5. The surgical device of claim 4 , wherein one of the lumens provides passage to a form of energy.6. The surgical device of claim 5 , wherein the form of energy is a laser beam.7. The surgical device of claim 1 , wherein a plurality of needles protrude from the distal end of the tube.8. The surgical device of claim 1 , further comprising an outer catheter ...

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Номер записи: 78
28-08-2014 дата публикации

Applicator for applying a liquid to a location on a body

Номер: US20140243756A1
Автор: Daniel M. BROBERG, Kevin Connelly, Kevin D. Mcintosh, Zachary W. MILLER
Принадлежит: Summit Medical Inc

An applicator for administering a liquid to a selected location of a patient includes a main body having an interior cavity and a flexible outer wall. A frangible ampoule is configured to contain the liquid and configured to be positioned within the interior cavity of the main body. A hypodermic tube having a proximal end attached to the main body and a distal end. An applicator tip attached to the distal end of the hypodermic tube to dispense the liquid.

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Номер записи: 79
28-08-2014 дата публикации

Rolled tip recovery catheter

Номер: US20140243884A1
Автор: John C. Oslund, Patrick P. Russo
Принадлежит: COVIDIEN LP

A distal tip for use with a medical catheter. The tip includes a member having a wall which defines a lumen therewithin. The wall has a portion at a distal end thereof, the portion curving inwardly toward an axis of the lumen. The lumen is provided with a diameter adaptable to accommodate a device to be recovered therewithin.

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Номер записи: 80
15-06-2017 дата публикации

Catheter Assembly Including a Multi-Lumen Configuration

Номер: US20170165453A1
Автор: Christian W. Crook, Kelli D. Oborn, Ryan T. Moehle, William R. Barron
Принадлежит: CR Bard Inc

A catheter assembly for use in accessing a vasculature of a patient is disclosed. In one embodiment, the catheter assembly includes a catheter body that includes a flattened oval outer surface and defines first and second lumens. The catheter body defines a distal tip region that includes a venous lateral opening that is in fluid communication with the first lumen and includes a distal-facing portion. The distal tip region further includes an arterial lateral opening that is in fluid communication with the second lumen, includes a distal-facing portion, and is substantially un-staggered with respect to the venous lateral opening. A distal end opening is in fluid communication with a power injectable third lumen. In another embodiment, the first and second lumens each generally include a reniform cross-sectional shape. In yet another embodiment, a dual-lumen catheter includes first and second lumens that each define a modified ellipse cross-sectional shape.

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Номер записи: 81
04-09-2014 дата публикации

CATHETER DEVICE WITH NEEDLE GUARD

Номер: US20140249488A1
Автор: Woehr Kevin
Принадлежит: B. BRAUN MELSUNGEN AG

The present disclosure relates to a catheter device comprising a catheter hub in which a valve member is disposed, a needle fixed in a needle hub, the needle extending through the valve member in the catheter hub in a ready position, and a tubular receptacle in which the needle hub is displaceably guided and biased by a spring in a proximal direction relative to the receptacle, wherein the needle hub is releasably held in the ready position in the receptacle against the force of the spring by frictional force between needle circumference and catheter or catheter hub, which frictional force is reduced on retraction of the needle through the catheter hub such that the force of the spring prevails. 1. A catheter device comprising:a catheter tube attached to a catheter hub in which a valve member is disposed;a needle fixed to a needle hub and extending through the valve member and having a needle tip extending distally of a distal end of the catheter tube in a ready position;a receptacle having a hollow interior in which the needle hub is displaceably guided and biased by a spring in a proximal direction relative to a distal end of the receptacle;wherein the needle hub is releasably held in the ready position in the receptacle against the force of the spring by a manually operated locking member; andwherein the valve comprises at least one slit and operable to permit fluid to flow thereacross.2. The catheter device according to claim 1 , wherein the locking member is releaseable by pressure transverse to a lengthwise axis of the receptacle to release the spring to thereby allow the spring to expand.3. The catheter device according to claim 1 , further comprising a projecting boss formed as a separate piece from the receptacle and projecting into the catheter hub.4. The catheter device according to claim 3 , wherein the projecting boss is a separate piece from the locking member.5. The catheter device according to claim 1 , further comprising a valve actuator positioned ...

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Номер записи: 82
04-09-2014 дата публикации

Systems and Methods for Delivering Drugs to Selected Locations Within the Body

Номер: US20140249507A1
Автор: Colloton Robert, Evard Philip, Flaherty Christopher, MacAulay Patrick, Makower Joshua, Whitt Jason
Принадлежит: Medtronic Vascular, Inc.

A transvascular system () for delivering a drug to a tissue region from a blood vessel, such as a coronary vein, includes a catheter () having a distal portion () with puncturing (), orientation (), drug delivery (), and imaging elements (). The puncturing element () is deployable for penetrating the vessel wall to access the tissue region. The orientation element (), e.g. a “cage” including a plurality of struts () () and/or a radiopaque marker, has a predetermined relationship with the puncturing element (), the imaging element () detecting the location of the orientation element () with respect to the tissue region to orient the puncturing element. The catheter () is percutaneously introducing into the vessel, the puncturing element () is oriented towards the tissue region, the puncturing element () is deployed to access the tissue region, and the drug is delivered to the tissue region. An ablation device () may also be deployed to create a cavity or fluid reservoir in the tissue region for receiving the drug therein, or an indwelling catheter () may be advanced into and left in the tissue region. 114-. (canceled)15. A catheter device for delivering a therapeutic substance to a perivascular treatment site , the catheter device comprising:an elongate catheter device extending along a catheter axis and having a distal portion advanceable within a blood vessel of a human subject;a needle at the distal portion of the catheter device, wherein the needle has a needle lumen in fluid communication with an outlet opening, and wherein the needle is moveable in a lateral direction relative to the catheter axis, and further wherein the needle is configured to penetrate a wall of the blood vessel;an injection port at a proximal portion of the catheter, the injection port being in fluid communication with the needle lumen; andat least one imageable marker useable to determine, by an imaging procedure, the lateral direction in which the needle will move from the distal portion ...

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Номер записи: 83
25-06-2015 дата публикации

Soft tip catheter

Номер: US20150174364A1
Автор: Geoff Clark, J. Michael Kennelly
Принадлежит: Smiths Medical ASD Inc

A catheter has a main portion made from an elongated tube and a soft tip that has softer flexural properties than the tube. The tip is affixed to the distal end of the tube. A reinforcement member is intermittently embedded in the body of the tube to provide kink and shear stress resistance as well as enhanced columnar strength and torque-ability to the catheter. With the flexible soft tip, the catheter is diverted when it meets an obstacle inside the patient to prevent the catheter from harming the patient. Another exemplar soft tip catheter is a one-piece elongated catheter with its distal portion selectively notched. A reinforcement member may be embedded along the length of the one-piece catheter or only along the main body portion. The notch at the distal portion may be a spiral cut or a number of ring cuts, with possibly different pitch, width and cut depth.

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Номер записи: 84
06-06-2019 дата публикации

EXPANDABLE CATHETER SYSTEM FOR FLUID INJECTION INTO AND DEEP TO THE WALL OF A BLOOD VESSEL

Номер: US20190167918A1
Автор: FISCHELL DAVID R., FISCHELL TIM A.
Принадлежит:

A catheter-based/intravascular fluid injection system with application to renal denervation includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic and/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable delivery system includes expandable components that facilitate positioning of a multiplicity of injection needles against the inside wall of a blood vessel from where they can be advanced. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel. 130-. (canceled)31. An intravascular nerve ablation system for delivery of an ablative fluid to a volume of tissue in proximity to a vessel wall of a target vessel comprising:a catheter body having a central axis;at least a first guide tube and a second guide tube, each guide tube having a distal end and a central lumen, each guide tube having a distal portion that is movable between a first position aligned with the central axis and a second position inclined away from the central axis;at least a first injector tube and a second injector, the first and second injector located coaxially inside of the first and second guide tubes respectively, wherein the distal ends of the first guide tube and the second guide tube are configured to press against, but not penetrate, the vessel wall of the target vessel as the first injector and the second injector are advanced into the volume of tissue; andwherein the first injector and the second injector are configured to advance relative to the first guide tube and the second guide tube, respectively, until the first injector and the second injector are prevented from forward movement relative to the first guide ...

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Номер записи: 85
04-06-2020 дата публикации

METHODS AND APPARATUSES FOR AMNIOTIC FLUID COLLECTION AND ISOLATION OF CELLS

Номер: US20200171097A1
Автор: HERBST Andreas Nils Walter, LARSSON Marcus Kare Torleif, WOODS Niels-bjarne Roland
Принадлежит:

Disclosed herein are methods and apparatuses for the safe, high-yield collection of sterile amniotic fluid. The apparatus are configured to allow sufficient flexibility for the device to gain access to all areas of the amniotic cavity, to allow sufficient stiffness for the amniotic fluid collection device to puncture the amniotic and chorionic membranes, yet allow sufficient suppleness to pose no significant risk of maternal or fetal harm. Further disclosed are cells isolated from the full-term amniotic fluid, and methods for using, reprogramming, and differentiating these cells. 1. An amniotic fluid collection device , comprising:a collection chamber;a collection chamber outlet valve coupled to the collection chamber;a collection chamber inlet valve coupled to the collection chamber;a proximal fluid-extraction tube coupled to the collection chamber inlet valve, the proximal fluid-extraction tube comprising a medical grade material; anda distal fluid-extraction tube coupled to the proximal fluid-extraction tube, the distal fluid extraction tube comprising a transfer portion and an inlet, wherein the inlet comprises a main inlet, a penetrating tip, and one or more lateral inlets.2. An isolated fetal or infant cell , comprising surface expression of a marker the surface of the cell is negative for CD105 expression; or', 'the surface of the cell expresses CD34., 'selected from the group consisting of CD73 and CD90, wherein3. The isolated cell of claim 2 , wherein the cell comprises surface expression of CD73 and CD90.457-. (canceled) This application claims priority to U.S. Provisional Patent Application Ser. No. 61/801,256, filed on Mar. 15, 2013, the contents of which are incorporated by reference herein.In one embodiment, the invention described herein relates to obtaining biological material, including amniotic fluid and cells, including at birth, and in some aspects relates to safe, high-yield collection of sterile amniotic fluid and devices and methods for the ...

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Номер записи: 86
18-09-2014 дата публикации

Methods and systems for treatment of a bladder

Номер: US20140276593A1
Автор: David Borzelleca, Michael F. Weiser, Sandra Nagale
Принадлежит: Boston Scientific Scimed Inc

A medical device is disclosed. The medical device may include an elongate member having a proximal end and a distal end an expandable end effector assembly extending distally from the distal end of the elongate member. The end effector assembly may include a plurality of end effector units each having an injector for simultaneously delivering material into tissue.

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Номер записи: 87
18-09-2014 дата публикации

Fluid delivery catheter with pressure-actuating needle deployment and retraction

Номер: US20140276621A1
Автор: Richard M. Braga
Принадлежит: COVIDIEN LP

A fluid delivery catheter that uses micro-needles for fluid delivery though a vessel wall. The catheter may provide fluid delivery therapy for various procedures, such as, for example, delivery of tumescent fluid or renal denervation. The catheter includes an elongate member with deployable and retractable needles disposed about a distal end of the elongate member. The needles may be disposed radially about the distal end and/or along a length of the distal end.

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Номер записи: 88
07-07-2016 дата публикации

CROSS-LINKABLE TISSUE BULKING COMPOSITIONS

Номер: US20160193383A1
Автор: Ankrum James, Cezo James D., KANGAS STEVEN L.
Принадлежит:

In some aspects, the present disclosure pertains to tissue bulking compositions that comprise: (a) solid particles comprising a pH-sensitive polymer that has a pH-dependent solubility such that the solid particles dissolve upon an increase or decrease in pH, (b) a crosslinking agent for the pH-sensitive polymer and (c) a pH modifying agent that generates acid or base in vivo, wherein when the tissue bulking composition comprises solid particles that dissolve upon a decrease in pH, the pH modifying agent generates acid in vivo and wherein when the tissue bulking composition comprises solid particles that dissolve upon an increase in pH, the pH modifying agent generates base in vivo. Other aspects of the present disclosure pertain to kits that comprise such compositions, to methods of forming injectable dispersions that comprise such compositions and to methods of treatment comprising injecting injectable dispersions that comprise such compositions into a subject. 1. A tissue bulking composition comprising: (a) solid particles comprising a pH-sensitive polymer that has a pH-dependent solubility such that the solid particles dissolve upon an increase or decrease in pH , (b) a crosslinking agent for the pH-sensitive polymer and (c) a pH modifying agent that generates acid or base in vivo , wherein when the tissue bulking composition comprises solid particles that dissolve upon a decrease in pH , the pH modifying agent generates acid in vivo and wherein when the tissue bulking composition comprises solid particles that dissolve upon an increase in pH , the pH modifying agent generates base in vivo.2. The tissue bulking composition of claim 1 , wherein the solid particles are less than 100 microns (μm) in size.3. The tissue bulking composition of claim 1 , wherein the tissue bulking composition is in the form of a dry powder or wherein the tissue bulking composition is an injectable dispersion that further comprises an aqueous or non-aqueous liquid.4. The tissue bulking ...

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Номер записи: 89
20-06-2019 дата публикации

INTRAVASCULAR DELIVERY OF NANOPARTICLE COMPOSITIONS AND USES THEREOF

Номер: US20190183789A1
Автор: Desai Neil P., SEWARD Kirk
Принадлежит:

The present invention provides methods of delivering a composition comprising nanoparticles that comprise a macrolide and an albumin by directly injecting the nanoparticle composition into the blood vessel wall or the tissue surrounding the blood vessel wall. The methods can be used for inhibiting negative remodeling or vascular fibrosis in the blood vessel and are useful for treating various diseases. 1. A method of inhibiting vascular fibrosis in a blood vessel in an individual in need thereof , comprising injecting into the blood vessel wall or tissue surrounding the blood vessel wall an effective amount of a composition comprising nanoparticles comprising rapamycin and an albumin.2. The method of claim 1 , wherein the vascular fibrosis is medial vascular fibrosis or adventitial fibrosis.3. The method of claim 1 , wherein the blood vessel is an artery.4. The method of claim 3 , wherein the artery is a coronary artery or a peripheral artery.5. The method of claim 3 , wherein the artery is selected from the group consisting of renal artery claim 3 , cerebral artery claim 3 , pulmonary artery claim 3 , and artery in the leg.6. The method of claim 1 , wherein the nanoparticle composition is injected into the blood vessel wall.7. The method of claim 1 , wherein the nanoparticle composition is injected into the tissue surrounding the blood vessel wall.8. The method of claim 7 , wherein the nanoparticle composition is injected into the adventitial tissue of the blood vessel.9. The method of claim 1 , wherein the nanoparticle composition is injected at a dose of about 0.001 mg to about 100 mg.10. The method of claim 9 , where the nanoparticle composition is injected at a dose of about 0.05 mg to about 5 mg.11. The method of claim 1 , wherein the injection volume of the nanoparticle composition is about 0.01 ml to about 50 ml.12. The method of claim 11 , wherein the injection volume of the nanoparticle composition is about 0.5 ml to about 5 ml.13. The method of claim 1 , ...

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Номер записи: 90
22-07-2021 дата публикации

METHODS AND SYSTEMS FOR TREATING DIABETES AND RELATED DISEASES AND DISORDERS

Номер: US20210220045A1
Автор: Caplan Jay, FLAHERTY J. Christopher, Gardner Craig M., Rajagopalan Harith
Принадлежит: Fractyl Laboratories, Inc.

Systems, devices and methods treat target tissue to provide a therapeutic benefit to the patient. A tissue treatment device comprises a tissue treatment element constructed and arranged to treat target tissue, such as duodenal mucosa and/or submucosal tissue. Patients treated can safely eliminate or reduce their daily insulin intake. 1. A method of treating a medical condition of a patient , the method comprising:selecting a patient diagnosed with type 2 diabetes that is being treated with daily insulin at a first dosage level and having a first HbA1c level of at least 7.5%; andperforming a tissue treatment procedure comprising treating one or more segments of the selected patient's intestinal tissue, wherein the tissue segments comprise duodenal mucosal tissue and/or duodenal submucosal tissue;wherein after the tissue treatment procedure is performed, the selected patient receives daily insulin at a second dosage level less than the first dosage level and maintains a second HbA1c level that is no greater than the first HbA1c level.2. The method according to claim 1 , wherein the selected patient has a c-peptide level of at least 0.5 ng/mL prior to the performing of the tissue treatment procedure.3. The method according to claim 1 , wherein the second HbA1c level comprises an HbA1c level of the selected patient measured 24 weeks after the performance of the tissue treatment procedure.4. The method according to claim 1 , wherein the second HbA1c level is less than the first HbA1c level.5. The method according to claim 4 , wherein the second HbA1c level comprises a level of at least 0.5% less than the first HbA1c level.6. The method according to claim 1 , wherein the second HbA1c level comprises an HbA1c level less than or equal to 7.5%.7. The method according to claim 6 , wherein the second HbA1c level comprises an HbA1c level less than or equal to 7.0%8. The method according to claim 6 , wherein the second dosage level is zero units of insulin per day.9. The method ...

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Номер записи: 91
23-07-2015 дата публикации

AGENTS, METHODS, AND DEVICES FOR AFFECTING NERVE FUNCTION

Номер: US20150202220A1
Автор: EVANS Michael A., STEIN Emily A., Swanson Christina D., VENKATESWARA-RAO Kondapavulur T.
Принадлежит: Northwind Medical, Inc.

Agents, methods, and devices for affecting nerve function are described. One embodiment of an agent includes a cardiac glycoside, an ACE inhibitor, and an NSAID. The agent may be delivered locally in a site-specific manner to a targeted nerve or portion of a nerve. For example, the agent may be delivered locally to the renal nerves to impair their function and treat hypertension. One embodiment of a delivery device includes one or more needle housings supported by a balloon. A delivery needle is slidably disposed within a needle lumen of each needle housing. 1. A method for treating hypertension in a patient , the method comprising:delivering a cardiac glycoside locally to a portion of a renal nerve in an amount sufficient to impair function of the renal nerve and lower a blood pressure of the patient.2. The method of claim 1 , wherein the amount of the cardiac glycoside delivered is sufficient to reduce a nerve conductance in the portion of the renal nerve.3. The method of claim 1 , wherein the amount of the cardiac glycoside delivered is sufficient to induce death of nerve cells in the portion of the renal nerve.4. The method of claim 1 , wherein the amount of the cardiac glycoside delivered is sufficient to induce death of nerve cells in the portion of the renal nerve and prevent regrowth of nerve cells.5. The method of claim 1 , wherein the amount of the cardiac glycoside delivered is sufficient to impair nerve function by acting on an axonal segment of the nerve cells in the portion of the renal nerve.6. The method of claim 1 , wherein the amount of the cardiac glycoside delivered is sufficient to impair nerve function by inducing neuro-muscular block claim 1 , sensory nerve block claim 1 , or clinical nerve block.7. The method of claim 1 , wherein the amount of the cardiac glycoside delivered does not cause damage to tissue surrounding the renal nerve.8. The method of claim 1 , wherein function of the renal nerve is impaired temporarily.9. The method of claim ...

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Номер записи: 92
23-07-2015 дата публикации

INJECTION NEEDLE INSERTION BARRIER

Номер: US20150202381A1
Автор: Schatz Richard A.
Принадлежит:

A catheter system includes a positioning catheter for receiving an injection needle into its lumen. Structurally, the injection needle incorporates a plurality of loops that are mounted directly onto its shaft. As the injection needle is moved in a distal direction to exit from the lumen of the catheter, the loops are individually biased to transition from a folded configuration, and into a deployed configuration. In their deployed configurations, the loops create a barrier that is oriented perpendicular to the needle. Thus, the barrier acts to limit the depth of insertion of the needle into target tissue of a patient, to a predetermined depth, and to prevent perforation of the target tissue by the catheter tip. 1. A catheter system for performing an injection of fluid medicament into a tissue of a patient which comprises:a catheter having a proximal end and a distal end, and formed with a lumen extending therebetween;an injection needle positioned on the catheter for reciprocating movement through the lumen of the catheter, wherein the injection needle has a proximal end and a distal end and defines an axis;a plurality of loops wherein each loop is an elongated wire having a first end and a second end and a midpoint therebetween to define a loop plane, wherein each end of the loop is affixed to the needle at respective points in a plane perpendicular to the axis of the needle, and wherein the loop is biased to transition in the loop plane between a folded configuration and a deployed configuration, and wherein during a configuration transition of the loop in the loop plane, the loop plane is rotated through a deployment angle β about an axis perpendicular to the axis of the needle, and further wherein each loop is affixed to the needle to avoid overlap and interference with another loop during the configuration transition; anda means for collectively moving the plurality of loops during their respective configuration transition to create a barrier wherein the ...

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Номер записи: 93
14-07-2016 дата публикации

CATHETER

Номер: US20160199616A1
Автор: Dye Philip J.
Принадлежит:

A catheter has an entrance opening defined by the first end of a catheter body and non-smooth inner surface. The entrance opening intersects a longitudinal axis extending longitudinally through the center of a lumen adapted to drain urine from a bladder. The non-smooth inner surface can have dimples, channels, or grooves, all of which decrease frictional fluid forces against the inner surface as the urine drains. The catheter is free of any eyelets formed in the side wall of the catheter body. The catheter is further free from any hemispheric tip located at one end. 1. An intermittent urinary catheter comprising:a tubular member including first and second ends that define a longitudinal axis therebetween, wherein the first end is adapted to be inserted into and move through a patient's urethral canal and into the patient's bladder;an outer surface spaced apart from an inner surface defining a lumen adapted to drain the fluid from the patient's bladder, and the outer surface having a diameter in a range from French Size 4 to French Size 30;an entrance opening to the lumen defined by a rounded endwall at the first end and a flat surface extending inwardly from the rounded end wall toward the lumen center, wherein the entrance opening is in fluid communication with the lumen and intersects the longitudinal axis; anda plurality of longitudinally extending channels formed in the inner surface.2. The intermittent urinary catheter of claim 1 , wherein the plurality of longitudinally extending channels begin proximate the first end and extend towards the second end.3. The intermittent urinary catheter of claim 2 , wherein the plurality of longitudinally extending channels begin in the flat surface.4. The intermittent urinary catheter of claim 3 , wherein a transverse cross section taken through the flat surface is non-circular.5. The intermittent urinary catheter of claim 1 , wherein there are eight channels and each one of the eight channels has one of: (i) an arcuate ...

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Номер записи: 94
14-07-2016 дата публикации

INTRAVASCULAR CATHETER HAVING AN EXPANDABLE PORTION

Номер: US20160199617A1
Автор: Pigott John P.
Принадлежит:

An apparatus and method for the treatment of intravascular medical conditions is provided. The device comprising a handle assembly, an expandable portion defined by a plurality of struts oriented along a longitudinal axis and a tip member affixed to a distal end of the struts. The struts are moveable between a collapsed and an expanded position. A catheter tube extends from the handle assembly to the expandable portion. An elongate member is disposed within the catheter tube and is in communication with the handle assembly and the tip member. 1. An intravascular catheter device for the treatment of various medical conditions comprising:a handle assembly;an expandable portion comprising a plurality of struts oriented along a longitudinal axis of the expandable portion configured to move between a collapsed and an expanded position and a tip member affixed to a distal end of said struts;a catheter tube extending from the handle assembly to the expandable portion, wherein said catheter tube defines an inner lumen; andan elongate member disposed within the inner lumen and in communication with the handle assembly and the tip member.2. The device of further comprising:a sheath disposed about the catheter tube.3. The device of further comprising:an attachment mechanism located on at least one of the plurality of struts configured to permit the attachment of a medical tool.4. The device of wherein:the struts having the attachment mechanism located thereon further comprise a recessed portion at the location of the attachment mechanism.5. The device of further comprising:the medical tool affixed to the attachment mechanism, wherein said medical tool is configured to provide a medical treatment.6. The device of wherein:the medical tool is an incising element which is oriented in parallel with a longitudinal axis of the expandable portion and extends outwardly in a radial direction therefrom.7. The device of wherein:the medical tool is a needle adapted to deliver a medication. ...

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Номер записи: 95
12-07-2018 дата публикации

Atraumatic Medical Device

Номер: US20180193592A1
Автор: Gainor John P., Valeti Uma S., Wilson Robert F.
Принадлежит: MedWerks, LLC

A catheter with a spring tip that facilitates atraumatic initial placement and also continues to protect tissue contacted by the catheter device subsequent to the initial placement. The spring tip is shock-absorbing and axially compliant and allows enhanced use of various devices in conjunction with the tip such as bioptomes, electrodes, needles, flushing catheters, delivery catheters, and the like. The atraumatic shock-absorbing tip could include conductive or non-conductive materials. 1. A method of engaging target tissue with a catheter comprising:navigating a catheter having a distal spring tip to target tissue;contacting the target tissue with the spring tip;axially compressing the spring tip against the target tissue;performing a procedure on the target tissue while maintaining contact between the tissue and the spring tip.2. The method of wherein navigating a catheter having a distal spring tip to target tissue comprises navigating a catheter having a mesh spring tip.3. The method of wherein navigating a catheter having a distal spring tip to target tissue comprises navigating a catheter having a foam spring tip.4. The method of wherein axially compressing the spring tip against the target tissue comprises advancing the catheter toward the target tissue.5. The method of wherein contacting the target tissue with the spring tip comprises magnetically attracting the spring tip to the target tissue.6. The method of wherein performing a procedure on the target tissue comprises sending electricity through the tissue using the spring tip as an electrode.7. The method of wherein maintaining contact between the tissue and the spring tip comprises positioning the spring tip such that biological movement of the target tissue is absorbed by the spring tip without affecting a position of the catheter.8. The method of wherein performing a procedure on the target tissue comprises advancing a tool through a lumen in the catheter and through the spring tip to engage the ...

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Номер записи: 96
12-07-2018 дата публикации

SYSTEMS AND METHODS FOR REDUCING OR PREVENTING BACKFLOW IN A DELIVERY SYSTEM

Номер: US20180193595A1
Автор: Anand PJ, Sama Blake, Singh Deep Arjun
Принадлежит: ALCYONE LIFESCIENCES, INC.

Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid. 17-. (canceled)8. A method of delivering a therapeutic agent to a patient , comprising:advancing a fluid conduit having a first outer sheath disposed therearound into tissue to compress tissue into a first tissue-receiving space defined between an exterior surface of the fluid conduit and an interior surface of the distal end of the first outer sheath, wherein first tissue-receiving space is defined between a substantially rectangular exterior cross-section of the first fluid conduit and a substantially circular interior cross-section of the first outer sheath; anddelivering fluid containing the therapeutic agent under positive pressure through the fluid conduit and into a portion of the tissue adjacent to a distal end of the fluid conduit.9. The method of claim 8 , wherein the first fluid conduit includes a substrate having one or more fluid channels formed on an outer surface of the substrate.10. The method of claim 9 , wherein the substrate has a rectangular exterior cross-section.11. The method of claim 9 , wherein the substrate is formed from silicon.12. The method of claim 8 , further comprising delivering a sealing gel through the fluid conduit claim 8 , before delivering the fluid containing the therapeutic agent claim 8 , to fill one or ...

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Номер записи: 97
12-07-2018 дата публикации

CATHETER SYSTEMS AND PACKAGED KITS FOR DUAL LAYER GUIDE TUBES

Номер: US20180193596A1
Автор: FISCHELL DAVID R., FISCHELL TIM A.
Принадлежит:

A catheter-based/intravascular ablation (denervation) system includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic or/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable needle delivery system is formed with self-expanding materials and include structures, near the end portion of the needles, or using separate guide tubes. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel. The preferred embodiment of the catheter delivered through the vascular system of a patient includes a multiplicity of expandable guide tubes that engage the wall of a blood vessel. Injection needles having injection egress at or near their sharpened distal end are then advanced through the guide tubes to penetrate the wall of the blood vessel to a prescribed depth. The ability to provide PeriVascular injection so as to only affect the outer layer(s) of a blood vessel without affecting the media has particular application for PeriVascular Renal Denervation (PVRD) of the sympathetic nerves which lie in the adventitia or outside the adventitia of the renal artery. 172-. (canceled)73. A packaged catheter , the catheter for placement into a vessel of a human body , the packaged catheter including:a catheter body with distal and proximal ends;at least one needle adapted to penetrate through a wall of the vessel;at least one needle guiding element, wherein a respective needle is disposed within a respective needle guiding element, wherein the at least one needle guiding element is movable between a closed configuration and an open configuration, wherein the at least one needle guiding element is configured to be ...

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Номер записи: 98
12-07-2018 дата публикации

Catheter system

Номер: US20180193601A1
Автор: Phillip Shaltis
Принадлежит: COVIDIEN LP

A catheter system includes an elongate catheter having a lumen extending at least partially therethrough, and a leading catheter end segment, a guidewire positionable within the lumen of the catheter, and fastening structure supported adjacent the leading catheter end segment. The guidewire and the catheter are adapted for relative movement. The fastening structure is dimensioned to selectively engage the guidewire to secure the guidewire with respect to the leading catheter end segment such that movement of the guidewire causes deflection of the leading end segment with respect to the longitudinal axis.

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Номер записи: 99
27-06-2019 дата публикации

DEVICES AND METHODS FOR ASSISTING CARDIAC FUNCTION

Номер: US20190192754A1
Автор: Kassab Ghassan S., Navia, SR. Jose A.
Принадлежит: CVDevices, LLC

Devices and methods for assisting cardiac function. In an exemplary embodiment of a device for assisting heart function of the present disclosure, the device comprises a first plate and an opposing second plate, each plate having an inner surface, a cardiac processor coupled to at least one of the first plate and the second plate, a bladder having an inner chamber and disposed between the inner surfaces, and a first catheter having a proximal end in communication with the inner chamber of the bladder and a distal end having a first pericardial balloon coupled thereto, wherein a gas and/or a liquid within the inner chamber of the bladder can be injected into the first pericardial balloon upon compression of the first plate relative to the second plate, and wherein the gas and/or the liquid can be removed from the first pericardial balloon upon retraction of the first plate relative to the second plate. 1. A method of assisting heart function , the method comprising the step of: a first catheter having a proximal end in communication with the source of the gas and/or the liquid and a distal end having a first pericardial balloon coupled thereto, and', 'a second catheter having a proximal end in communication with a portion of the device and a distal end having a second pericardial balloon coupled thereto;, 'introducing at least part of a device for assisting heart function into a pericardial space surrounding a heart, the device comprisingwherein the introducing step is performed to position at least one of the first pericardial balloon and/or the second pericardial balloon into the pericardial space.2. The method of claim 1 , wherein the introducing step is performed to position the first pericardial balloon into the pericardial space at or near a first heart chamber claim 1 , and wherein the method further comprises the step of:introducing a gas and/or a liquid into the first pericardial balloon so that the first pericardial balloon exerts pressure upon the first ...

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Номер записи: 100