МЕДИЦИНСКОЕ УСТРОЙСТВО (ВАРИАНТЫ)

Изобретения относятся к медицинской технике, а именно к медицинскому устройству, содержащему полую конструкцию и доставляющий катетер для лечения сегментов кровеносных сосудов сосудистой системы. Медицинское устройство для окклюзии или блокирования сегментов кровеносного сосуда содержит катетер и сжатую полую металлическую конструкцию, присоединенную к катетеру. Металлическая конструкция, когда она расширена, содержит один сегмент, имеющий стенку с внутренней поверхностью, образующей полость, и внешнюю поверхность с отверстием, ограниченным стенкой, которое позволяет проходить текучей среде в полость. Полость полой металлической конструкции и просвет катетера могут быть соединены текучей средой, а проход текучей среды из катетера в полость полой металлической конструкции приводит к ее расширению. Медицинское устройство сконфигурировано так, что расширенная полая металлическая конструкция и катетер могут быть разъединены. Расширенная полая металлическая конструкция имеет достаточную жесткость ...

БАЛОННЫЙ СТЕНТ И СПОСОБ ЕГО ПРИМЕНЕНИЯ

... 1. Медицинское устройство, содержащее:катетер исжатую полую металлическую конструкцию, присоединенную к катетеру, причем металлическая конструкция, когда она расширена, содержит один сегмент, имеющий стенку с внутренней поверхностью, образующей полость, и внешнюю поверхность с отверстием, определенным стенкой, которая позволяет проходу текучей среды в полость, причем полость металлической конструкции и полость катетера могут быть соединены текучей средой, а проход текучей среды из катетера в полость металлической конструкции приводит к ее расширению.2. Медицинское устройство по п.1, отличающееся тем, что форма расширенной металлической конструкции закруглена.3. Медицинское устройство по п.1, отличающееся тем, что стенка металлической конструкции содержит материал, выбранный из группы, состоящей из золота, платины, серебра, их сплавов и их сочетаний.4. Медицинское устройство по п.1, отличающееся тем, что металлическая конструкция имеет расширенный диаметр в диапазоне от приблизительно 2 ...

IMPLANTIERBARES INFUSIONSGERÄT MIT VORSCHIEBBARER UND ZURÜCKZIEHBARER NADEL

Methods of treatment

Therapeutic foam.

PROCEDURE FOR THE PRODUCTION OF A FOAM WITH A SKLEROSIERENDEN MEANS

IMPLANTIERBARES INFUSION EQUIPMENT WITH EXTENDABLE AND RETRACTABLE NEEDLE

Organ preservation and/or perfusion solutions

An organ preservation and/or perfusion solution for an isolated tissue or organ is provided. The solution comprises dextran, glucose, calcium ions, a buffer, and water, has a pH of 6,6 to 7,8, and is sterile based on having been subjected to heat sterilization. A method of preparing the solution also is provided. The method comprises combining dextran, glucose, calcium ions, buffer, and water to obtain an initial solution, adjusting the pH of the initial solution to 7,0 to 7,8 if needed, and subjecting the initial solution to heat sterilization, thereby obtaining the organ preservation and/or perfusion solution. A method of preserving and/or perfusing an isolated tissue or organ also is provided. A method for flushing, storage, and/or transportation of an isolated lung after removal from a donor in preparation for eventual transplantation into a recipient also is provided.

Cannula capture mechanism

A cannula capture mechanism (12) may include an inner housing (18), outer housing (20), and a cannula (14). The outer housing may be configured to move between a compressed and a decompressed state. An outer surface of the inner housing may include one or more interlock components (46). When the cannula is exposed from a distal end of the inner housing, the one or more interlock components may interact with one or more interlock surfaces formed in another surface of the catheter device. When the cannula is retracted proximally within the inner housing, the inner housing may contract radially inward causing the one or more interlock components to be separated from the one or more interlock surfaces and the outer housing to move to the decompressed state and extend distally over a distal portion of the inner housing.

Low-drag septum for a catheter system

A peripheral intravenous catheter assembly may include a low-drag septum. The septum may include a body having a distal end and a proximal end, which may be sealed. The septum may include a slot disposed within an outer surface of the body and oriented along a longitudinal axis of the body. The slot may include a distal end spaced apart from the distal end of the body, and a proximal end spaced apart from the proximal end of the body. An introducer needle may extend through the slot.

Producing a guideware comprising a position sensor

A method for producing a guidewire, the method includes producing a position sensor by providing a shaft section having a solid profile, which is sized and shaped 5 to move in an anatomical material transportation system. A wire is wound around an axis of the shaft-section and first and second ends of the wire are coupled to respective first and second locations on an outer surface of the shaft section. A guidewire-shaft is provided, and the position 10 sensor is coupled to a distal end of the guidewire-shaft.

Sheathless guide, rapid exchange dilator and associated methods

SHEATHLESS GUIDE, RAPID EXCHANGE DILATOR AND ASSOCIATED METHODS Dilators, such as rapid exchange dilators, configured for percutaneous access are disclosed. The dilator (100) may be configured to be disposable within, or couplable with, a catheter. In some embodiments, the dilator (100), or the coupled dilator and the catheter, may be configured such that a sheath is not required for percutaneous access. In other embodiments, the dilator (100) may comprise a plug (114) such that a guide wire may be directed from a distal end (106) of the dilator (100) through a port (110), such as a rapid exchange port, in a sidewall of the dilator. The plug (114) may also be configured to permit passage of fluid through a lumen (108) of the dilator (100) while inhibiting passage of the guide wire through a length of the dilator (100).

Sheathless guide, rapid exchange dilator and associated methods

SHEATHLESS GUIDE, RAPID EXCHANGE DILATOR AND ASSOCIATED METHODS Dilators, such as rapid exchange dilators, configured for percutaneous access are disclosed. The dilator (100) may be configured to be disposable within, or couplable with, a catheter. In some embodiments, the dilator (100), or the coupled dilator and the catheter, may be configured such that a sheath is not required for percutaneous access. In other embodiments, the dilator (100) may comprise a plug (114) such that a guide wire may be directed from a distal end (106) of the dilator (100) through a port (110), such as a rapid exchange port, in a sidewall of the dilator. The plug (114) may also be configured to permit passage of fluid through a lumen (108) of the dilator (100) while inhibiting passage of the guide wire through a length of the dilator (100).

Intravascular tissue disruption

Disrupting tissue and devices and systems for disrupting tissue. The disclosure describes ways to deliver moieties to a target tissue, where the target tissue in general is not at the point of introduction, in such a way that minimal damage is produced in the tissue at the point of introduction. In some embodiments this is accomplished by jetting fluid at high velocity into the target tissue. The disclosure further describes novel agents deliverable in such systems for use in remodeling tissues. Some of these agents comprise a liquid while others do not. Additionally, although not specifically described in detail much of the disclosure may additionally be used in the delivery of therapeutic drugs.

Renal pump

Apparatus and methods are described including identifying a subject as suffering from a condition selected from the group consisting of: cardiac dysfunction, congestive heart failure, reduced renal blood flow, increased renal vascular resistance, arterial hypertension, and kidney dysfunction. In response thereto, blood pressure within a renal vein (32) of the subject is reduced, by placing a blood pump (150) inside the subject's renal vein and activating the impeller to pump blood from the renal vein into the subject's vena cava (26). Other applications are also described.

Drug delivery medical device

A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer layer. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer layer; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.

Rapid aspiration thrombectomy system and method

An intravascular access system for facilitation of intraluminal medical procedures within the neurovasculature through an access sheath. The system includes an aspiration or support catheter (1320) having a flexible, distal luminal portion (1322) having an inner diameter defining a lumen (1323) extending between a proximal opening at a proximal end of the luminal portion and a distal opening at a distal end of the luminal portion. The catheter has a rigid spine (1330) coupled to at least the proximal end of the luminal portion and extending proximally therefrom. The system includes a dilator (1340) having a flexible, distal dilator portion (1360) sized to be received within the lumen (1323) of the luminal portion (1322). Associated systems, devices, and methods of use are also described.

Method and device for treating blood cholesterol disorders

Abstract A method and device for treating cholesterol disorders includes administering at least one treatment regime including two or more rounds of plasmapheresis to a patient having abnormal total cholesterol, abnormal LDL levels and/or abnormal HDL levels prior to treatment. Treatment according to the method results in decreased LDL levels in patients having abnormal LDL levels and increased HDL levels in patients having abnormal HDL levels. Each subsequent round of plasmapheresis is conducted weekly, but no more than twice per week. Fig. 1 ...

Blockstent device and methods of use

What is disclosed is a medical device comprising a compressed, cylindrical or oblong, thin-walled, expandable metal structure (a "blockstent") and a flexible, elongated device (a "delivery catheter") to position the compressed blockstent into the lumen of a blood vessel segment to be treated, and methods of use for occlusion of treated blood vessel segments. A blockstent can be made with ductile meta!s such that the blockstent will conform to the shape of the lumen of the treated blood vessel segment during expansion and allow for the shape of the blockstent to be permanently changed by the application of an external force. The surface of the blockstent can be configured to promote local thrombus on the external surface of the blockstent and to promote the growth of tissue into the wall of the blockstent in order to occlude the treated blood vessel and fix the blockstent in place.

Ballstent device and methods of use

What is disclosed are medical devices comprising a rounded, thin-walled, expandable metal structure ("ballstent") and a flexible, elongated delivery device ("delivery catheter") and systems and methods of use for treating saccular vascular aneurysms with the medical devices. Ballstents comprised of gold, platinum, or silver that can be compressed, positioned in the lumen of an aneurysm, and expanded to conform to the shape of the aneurysm are disclosed. The external surface of ballstents can be configured to promote local thrombosis and to promote the growth of tissue into and around the wall of the ballstent in order to seal the aneurysm and fix the ballstent in place in the aneurysm. The wall of the ballstent can also be configured to release drugs or pharmacologically active molecules, such as those that promote thrombosis, cell proliferation, extracellular matrix deposition, and tissue growth.

Drug delivery medical device

Abstract A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer layer. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer layer; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.

Cannula capture mechanism

A cannula capture mechanism is described herein. The capture mechanism may include an inner housing, outer housing, and a cannula. The outer housing may be configured to move between a compressed and a decompressed state. An outer surface of the inner housing may include one or more interlock components. When the cannula is exposed from a distal end of the inner housing, the one or more interlock components may interact with one or more interlock surfaces formed in another surface of the catheter device. When the cannula is retracted proximally within the inner housing, the inner housing may contract radially inward causing the one or more interlock components to be separated from the one or more interlock surfaces and the outer housing to move to the decompressed state and extend distally over a distal portion of the inner housing. ---- 50 542-/ 62 -64 --- 40 34 32 5 r -- 54 --- 3860 32 5848 52 42-," 62 64 ...

ERGONOMIC IV SYSTEMS AND METHODS

RAPID ASPIRATION THROMBECTOMY SYSTEM AND METHOD

An intravascular access system for facilitation of intraluminal medical procedures within the neurovasculature through an access sheath. The system includes an aspiration or support catheter (1320) having a flexible, distal luminal portion (1322) having an inner diameter defining a lumen (1323) extending between a proximal opening at a proximal end of the luminal portion and a distal opening at a distal end of the luminal portion. The catheter has a rigid spine (1330) coupled to at least the proximal end of the luminal portion and extending proximally therefrom. The system includes a dilator (1340) having a flexible, distal dilator portion (1360) sized to be received within the lumen (1323) of the luminal portion (1322). Associated systems, devices, and methods of use are also described.

METHOD AND DEVICE FOR INFUSION OF PHARMACOLOGIC AGENTS AND THROMBUS ASPIRATION IN ARTERY

A catheter device and method for treating an artery with thrombus, the catheter comprising an inflatable member. A carrier catheter has a proximal end and a distal end adapted to be inserted percutaneously into an artery, the carrier catheter having a tubular body adjacent to a rear end of the inflatable member. An inflating tube passes through the tubular body and having an open front end in fluid communication with the inflatable member to inflate same. An infusion tube is adapted to infuse pharmacologic agents, the infusion tube passing through the tubular body and having an open front end extending beyond the inflatable member. An aspiration tube is adapted to aspire the thrombus, the aspiration tube passing through the tubular body and having an open front end between the carrier catheter and the inflatable member.

SYSTEM FOR RE-ENTERING A VESSEL LUMEN

This disclosure is directed to systems and methods for re-entering the true lumen of a vessel. The re-entry catheters (10) employ deflectable struts (20) to stabilize and support the distal tip (16) in a subintimal location while a passageway back into the true lumen is formed. Re-entry to the true lumen can be effected with a cutting element or with a conventional guidewire.

MEDICAL PROBE WITH FLUID ROTARY JOINT

A catheter is provided that includes an external sheath, a rotatable conduit housed within the external sheath, and a fluid rotary joint having a rotatable insert that places an inner lumen of the rotatable conduit in fluid communication with an external port under rotation of the rotatable conduit. The rotatable insert may include a channel structure including an external annular channel. The rotatable conduit is received within the channel structure such that the inner lumen is in fluid communication with the external port through the annular channel under rotation of the rotatable conduit. The external sheath may define an outer lumen that may be in fluid communication with the inner lumen at a location remote from a proximal portion of the catheter, and the outer lumen may be in fluid communication with a secondary port. The rotatable conduit may be housed within a torque cable that is connected to the rotatable insert.

BLOCKSTENT DEVICE AND METHOD OF USE

What is disclosed is a medical device comprising a compressed, cylindrical or oblong, thin-walled, expandable metal structure (a "blockstent") and a flexible, elongated device (a "delivery catheter") to position the compressed blockstent into the lumen of a blood vessel segment to be treated, and methods of use for occlusion of treated blood vessel segments. A blockstent can be made with ductile metals such as gold, platinum, or silver such that the blockstent will conform to the shape of the lumen of the treated blood vessel segment during expansion and allow for the shape of the blockstent to be permanently changed by the application of an external force. The surface of the blockstent can be configured to promote local thrombus on the external surface of the blockstent and to promote the growth of tissue into the wall of the blockstent in order to occlude the treated blood vessel and fix the blockstent in place. The wall of the blockstent can also be configured to release drugs or pharmacologically ...

GENERATING ARTIFICIAL PULSE

In order to produce a pulsatile blood flow pattern that includes time periods of relatively high blood flow rates and time periods of relatively low blood flow rates, the operating speed of a blood pump can be selectively controlled to produce an operating speed pattern that includes time periods of relatively high rotation speeds and periods of relatively low rotation speeds. For example, the blood pump is rotated at a first speed for a first period of time. The speed of the blood pump is then decreased from the first speed to a second speed and is operated at the second speed for a second amount of time. The speed of the blood pump is then decreased to a third speed for a third amount of time. If desired, the operating speed pattern can be repeated to continue the pulsatile blood flow pattern.

THERAPEUTIC FOAM

Detachable micro-catheter with double-coating at the head end

Double-container balanced lavaging device for hematoma remover

IMPLANTABLE INFUSION DEVICE WITH NEEDLE THAT CAN ADVANCE AND RETRACT

INJECTION DEVICE USING DRY CARRIER

An active agent injecting device dispenses a measured amount of active agent into a living organism. The injecting device includes a main housing, an injection assembly and a trigger mechanism. The main housing houses the operative components of the device. The needle encloses a carrier having an active agent disposed thereon. The trigger mechanism triggers the injection assembly to release the needle to inject the active agent into the living organism.

MICRONEEDLE-CONTAINING DRUG DELIVERY DEVICE TO BE ATTACHED TO EXTERIOR WALL OF VASCULAR VESSEL AND METHOD FOR DRUG DELIVERY THEREWITH

The present invention relates to a drug delivery device, which comprises a microneedle, and which is to be attached to the exterior wall of a vascular vessel, and to a drug delivery method, and more specifically, to a drug delivery device, which is to be attached to the exterior wall of a vascular vessel and to a drug delivery method using same. The drug delivery device comprises: a) a biocompatible device body for surrounding a vascular vessel; b) one or plurality of biocompatible microneedle, which are connected to the interior of the biocompatible device body and capable of penetrating up to the tunica media so as to deliver drug to the smooth muscle cells. The drug delivery device and method according to the present invention enable spatial and temporal control of the drug ejected onto the blood cells and enable insertions of two or more different drugs at different delivery speeds and durations, thereby significantly improving the treatment success rate.

NEUROVASCULAR CATHETER HAVING ATRAUMATIC ANGLED TIP

A neurovascular catheter having an angled distal tip has an elongate flexible tubular body with a proximal end, a distal end and a side wall defining a central lumen. The side wall has a helical coil. A tubular jacket surrounds the helical coil, and extending distally beyond the helical coil distal end to terminate in a catheter distal face. A tubular radiopaque marker is embedded in the tubular jacket in between the distal end of the coil and the distal face. The distal face resides on a plane which crosses a longitudinal axis of the tubular body at an angle within the range of from about 35 degrees to about 55 degrees. The marker has a proximal face that is approximately perpendicular to the longitudinal axis and a distal face that resides on a plane which crosses the longitudinal axis at an angle within the range of from about 35 degrees to about 55 degrees.

Therapeutic foam

A therapeutic foam for the treatment of, inter alia, varicose veins comprises a sclerosing solution foamed with a physiological gas such as carbon dioxide, oxygen or a mixture thereof. The foam has a nitrogen content of less than 0.8%. It may be generated using a pressurized canister system incorporating a fine mesh of micron dimensions through which the gas and sclerosing liquid are passed to make the foam. Alternatively, the foam may be generated by passing gas and solution between two syringes through a fine mesh. Techniques are described for minimizing the amount of nitrogen in a canister or syringe based product. A technique for generating and delivering foam simultaneously using a syringe based device is also disclosed.

Generating artificial pulse

In order to produce a pulsatile blood flow pattern that includes time periods of relatively high blood flow rates and time periods of relatively low blood flow rates, the operating speed of a blood pump can be selectively controlled to produce an operating speed pattern that includes time periods of relatively high rotation speeds and periods of relatively low rotation speeds. For example, the blood pump is rotated at a first speed for a first period of time. The speed of the blood pump is then decreased from the first speed to a second speed and is operated at the second speed for a second amount of time. The speed of the blood pump is then decreased to a third speed for a third amount of time. If desired, the operating speed pattern can be repeated to continue the pulsatile blood flow pattern.

System and method for traversing an arterial occlusion

A system for traversing an arterial occlusion in an artery includes a housing sized to fit in a palm of a user, an elongate drive tube configured to be rotated by the housing, the drive tube including an axially extending passage, a cylindrical member, configured to be rotationally coupled to the drive tube, such that a distal tip of the cylindrical member may be delivered to a location adjacent the arterial occlusion when the cylindrical member is coupled to the drive tube, and wherein grasping and activating the housing such that the drive tube is rotated, thereby causes the distal tip of the cylindrical member to be rotated, the rotation of the distal tip including at least a component of linear oscillation.

Circumferentially offset variable porosity devices

An implantable device for treating a vascular cavity or vascular malformation may include a plurality of wires woven to form a textile structure expandable from a compressed state to an expanded state. The textile structure may have a longitudinal axis and may include, in the expanded state, a first longitudinal segment, a second longitudinal segment, and a lumen configured to allow perfusion of blood through the textile structure parallel to the longitudinal axis. The first longitudinal segment may include a first circumferential portion including a first braid angle and a second circumferential portion opposite the first circumferential portion and including a second braid angle greater than the first braid angle. At least one of the first longitudinal segment and the second longitudinal segment may comprise a bulb.

A PERFUSION BALLOON WITH AN EXPANDABLE INTERNAL LUMEN

The present invention relates to a perfusion balloon catheter that has an expandable (enlargeable) inner lumen (114) with a novel design feature that allows a continuous flow through this enlarged lumen sufficient perfusion to the distal lumen of the blood vessel or air passage concurrent to and independently of balloon (104) inflation or deflation resulting in the prolonged dilatation and avoiding the high risks of blood or air flow stricture during balloon inflation.

System and methods for removing undesirable material within a circulatory system utilizing during a surgical procedure

A method for capturing dislodged vegetative growth during a surgical procedure is provided. The method includes maneuvering, into a circulatory system, a first cannula having a distal end and an opposing proximal end, such that the first cannula is positioned to capture the vegetative growth en bloc. A second cannula is positioned in fluid communication with the first cannula, such that a distal end of the second cannula is situated in spaced relation to the distal end of the first cannula. A suction force is provided through the distal end of the first cannula so as to capture the vegetative growth. Fluid removed by the suction force is reinfused through the distal end of the second cannula. Subsequent to becoming dislodged, the vegetative growth is captured by the first cannula. A method for capturing a vegetative growth during removal of a pacemaker lead is also provided.

СПОСОБ И УСТРОЙСТВО ДЛЯ ЛЕЧЕНИЯ НАРУШЕНИЙ, СВЯЗАННЫХ С УРОВНЕМ ХОЛЕСТЕРИНА В КРОВИ

Изобретение относится к медицине, а именно к терапии. Применяют схему лечения, включающую два или более сеансов плазмафереза, у пациента, имеющего патологический уровень общего холестерина, патологический уровень ЛПНП и патологический уровень ЛПВП, измеряемые перед началом лечения. При этом схема лечения снижает уровень общего холестерина, снижает уровень ЛПНП у пациентов, имеющих патологический уровень ЛПНП, и повышает уровень ЛПВП у пациентов, имеющих патологический уровень ЛПВП. Каждый последующий сеанс лечения проводят через 2-14 дней после предшествующего сеанса, где каждый сеанс включает низкообъемный плазмаферез, при котором обрабатывают менее чем около 1000 мл крови. При этом применяют устройство, включающее: футляр, входной порт для получения цельной крови от донора, средства для отделения плазмы от клеточных компонентов цельной крови и средства для возврата клеточных компонентов цельной крови донору. Способ позволяет повысить уровень ЛПВП у пациентов, имеющих патологический уровень ...

РАСТВОРЫ ДЛЯ КОНСЕРВАЦИИ И/ИЛИ ПЕРФУЗИИ ОРГАНОВ

Изобретение относится к области биотехнологии, а именно к раствору для консервации изолированной ткани или изолированного органа, приготовлению указанного раствора, консервации изолированной ткани или изолированного органа, к способу промывания, хранения и/или транспортировки изолированного легкого после его удаления у донора в процессе подготовки к последующей трансплантации реципиенту. Способ включает объединение декстрана, глюкозы, ионов кальция, буфера и воды с получением начального раствора. Затем осуществляют доведение рН начального раствора до значения, лежащего в диапазоне от 7,2 до 7,6, если это необходимо. Далее проводят тепловую стерилизацию начального раствора с получением раствора для консервации изолированной ткани или изолированного органа. Полученный раствор используется для консервации, а также промывания, хранения и/или транспортировки изолированного органа или ткани путем введения указанного раствора в изолированную ткань или изолированный орган. Изобретение позволяет ...

МЕДИЦИНСКОЕ УСТРОЙСТВО (ВАРИАНТЫ)

Multitube catheter assembly and a method for making

The assembly includes two or more tubes T1, T3 fused together to form a single tube shaft, at least one of the tubes being formed of a pressure resistant material. The tubes are fused by a heat shrinkable tube slide placed over a segment of catheter tubes while metallic mandrels M1, M2 are passed through each tube lumen to protect the lumens during fusion. The heat shrinkable tube will shrink and apply the required pressure over the catheter tubes. Continual heating will melt and re-shape the catheter tubes inside the heat shrinkable tube while the latter will not be affected due to its high melting temperature. After cooling, the heat shrinkable tube is removed and the metallic mandrels are pulled back. One or more of the tubes can be of different hardness, material and/or color. The difference will provide pressure resistant lumens, overall catheter elasticity and/or identification. The distal end of the united catheter tube can be split, free floating, stepped, tapered tipped or have ...

Implantable infusion device with advanceable and retractable needle

System and method for treatment via bodily drainage or injection

Devices and methods of treating fluid retention caused by congestive heart failure or other conditions resulting in edema, lymphoedema, or significant fluid retention (e.g., deep vein thrombosis, cellulitis, venous stasis insufficiency, or damage to the lymphatic network) are described. Specifically, a treatment device is used to create a passage or cannula between the lymphatic system (or other area of the body) and an external drainage device. This device can be only temporarily located in the patient or can be implanted within the patient for longer periods of time. The physician can safely and reliably remove excess fluid from the body via the device and optionally inject other treatment agents.

Biocompatible and hemocompatible material and filter

A biocompatible and hemocompatible material and filter which is suitable for blood filtration applications. Biocompatibility and hemocompatibility is achieved through a modification of an existing ceramic substrate, in which a pyrolytic carbon layer is coated onto the filter.

Integrated catheter with independent fluid paths

Catheter systems (100) comprising independent fluid paths are disclosed. The catheter systems includes a catheter adapter (102) that has a catheter hub (120) with a chamber (126). A catheter (115) extends from a distal end (122) of the catheter hub and is in fluid communication with the chamber. A stabilization platform (118) with a first wing (146) and a soft push tab (142) are also part of the catheter hub. The catheter system includes a needle hub (104) with a needle (172) that slidably fits within the catheter. In an insertion configuration, a proximal extension of the catheter hub is removably coupled within a distal opening of the needle hub. After the catheter is placed, the needle hub is retracted from the catheter adapter to slidably remove the needle from the catheter.

Organ preservation and/or perfusion solutions

An organ preservation and/or perfusion solution for an isolated tissue or organ is provided. The solution comprises dextran, glucose, calcium ions, a buffer, and water, has a pH of 6,6 to 7,8, and is sterile based on having been subjected to heat sterilization. A method of preparing the solution also is provided. The method comprises combining dextran, glucose, calcium ions, buffer, and water to obtain an initial solution, adjusting the pH of the initial solution to 7,0 to 7,8 if needed, and subjecting the initial solution to heat sterilization, thereby obtaining the organ preservation and/or perfusion solution. A method of preserving and/or perfusing an isolated tissue or organ also is provided. A method for flushing, storage, and/or transportation of an isolated lung after removal from a donor in preparation for eventual transplantation into a recipient also is provided.

Ergonomic IV systems and methods

An IV catheter system may have a catheter component with a catheter hub, a cannula extending distally from the catheter hub, and a push feature adjacent to the catheter hub. The IV catheter system may also have a needle component with a needle hub, a needle extending distally from the needle hub along an axis, and a grip extending from the needle hub, generally parallel to the axis, with a pull feature. In the insertion configuration, the needle may be positioned within the cannula and the distal end of the needle hub may be seated in a needle port of the catheter hub. In the fluid delivery configuration, the needle may be positioned outside the catheter hub. The push and pull features may be positioned to facilitate manipulation with a single hand to move the IV catheter system from an insertion configuration to a fluid delivery configuration. 200 270 252 0' 268 v204 226 228 22 214 - 236 212 264 262 260 202 270 250 222-'24 22420 300-x /354 _/326 346 328 332 370 334 ,352 322 30/ -- 6 336 ...

BLOCKSTENT DEVICE AND METHODS OF USE

Examiner's Abstract for AU2020200482 A medical device for occluding an artery or a vein, the medical device comprising: a compressed, hollow structure, wherein the structure, when expanded, comprises a single lobe, having a wall comprising a polymer layer and a metal layer, the wall defining an interior surface further defining a void, and an exterior surface, with an opening in the wall that allows for the passage of fluid into the void, and wherein the passage of fluid into the void of the hollow structure results in expansion of the hollow structure; and wherein the expanded hollow structure has sufficient rigidity to remain in an expanded state when implanted in vivo in an unsealed configuration.

Radiopaque medical balloon

A medical balloon (10) is made radiographic, such as by incorporating a radiopaque foil 5 (36) or film layer (35). The radiopaque foil or film layer may be placed between an inner layer (30) and an outer layer (32) of a non-compliant balloon wall. The foil or film may provide the balloon with a radiographic quality from a first end to a second end in the absence of an inflation fluid. The balloon may be provided with the foil or film in a manner that provides a first section, such as the barrel (16), with a first radiographic 10 quality, and a second section, such as the cone (18, 20), with a second radiographic quality. The film may also be applied as a decal or applique to the external surface of a balloon-shaped body. Related methods are also disclosed. --24 "26 ...

RENAL PUMP

An impeller is disclosed. The impeller includes an impeller frame with proximal and distal end portions and at least two helical elongate elements. The helical elongate elements wind from the proximal end portion to the distal end portion. A film of material is coupled to the at least two helical elongate elements, such that the helical elongate elements with the material coupled thereto define a blade of the impeller. The film of material is an elastomer that is shaped to define a hollow central lumen therethrough.

SYSTEM FOR TREATING EMBOLISM AND ASSOCIATED DEVICES AND METHODS

Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, positioning a distal portion of a catheter proximate to the clot material within the blood vessel. The method can further include coupling a pressure source to the catheter via a tubing subsystem including a valve or other fluid control device and, while the valve is closed, activating the pressure source to charge a vacuum. The valve can then be opened to apply the vacuum to the catheter to thereby aspirate at least a portion of the clot material from the blood vessel and into the catheter.

SYSTEM AND METHOD FOR TREATMENT VIA BODILY DRAINAGE OR INJECTION

Devices and methods of treating fluid retention caused by congestive heart failure or other conditions resulting in edema, lymphoedema, or significant fluid retention (e.g., deep vein thrombosis, cellulitis, venous stasis insufficiency, or damage to the lymphatic network) are described. Specifically, a treatment device is used to create a passage or cannula between the lymphatic system (or other area of the body) and an external drainage device. This device can be only temporarily located in the patient or can be implanted within the patient for longer periods of time. The physician can safely and reliably remove excess fluid from the body via the device and optionally inject other treatment agents.

CANNULA WITH LIGHT-EMITTING OPTICAL FIBER

A catheter device to visually identify a blood vessel may include a cannula. The cannula may include a distal tip, an elongated tubular shaft, and an inner lumen formed by the elongated tubular shaft. The cannula may also include an optical fiber, which may be disposed within the inner lumen of the cannula. The optical fiber may include a distal end and a proximal end. The optical fiber may be configured to emit light from the distal end.

INTRAVASCULAR TISSUE DISRUPTION

Disrupting tissue and devices and systems for disrupting tissue. The disclosure describes ways to deliver moieties to a target tissue, where the target tissue in general is not at the point of introduction, in such a way that minimal damage is produced in the tissue at the point of introduction. In some embodiments this is accomplished by jetting fluid at high velocity into the target tissue. The disclosure further describes novel agents deliverable in such systems for use in remodeling tissues. Some of these agents comprise a liquid while others do not. Additionally, although not specifically described in detail much of the disclosure may additionally be used in the delivery of therapeutic drugs.

MEDICAL PROBE WITH FLUID ROTARY JOINT

A catheter is provided that includes an external sheath, a rotatable conduit housed within the external sheath, and a fluid rotary joint having a rotatable insert that places an inner lumen of the rotatable conduit in fluid communication with an external port under rotation of the rotatable conduit. The rotatable insert may include a channel structure including an external annular channel. The rotatable conduit is received within the channel structure such that the inner lumen is in fluid communication with the external port through the annular channel under rotation of the rotatable conduit. The external sheath may define an outer lumen that may be in fluid communication with the inner lumen at a location remote from a proximal portion of the catheter, and the outer lumen may be in fluid communication with a secondary port. The rotatable conduit may be housed within a torque cable that is connected to the rotatable insert.

Reworking method of balloon catheter guide wire outlet

볼스텐트 장치 및 사용방법

... 본 발명에 기술된 내용은 둥글고, 얇은 벽 구조이며, 팽창할 수 있는 금속 구조물("볼스텐트") 및 가요성의 기다란 전달 장치("전달 카테터")를 포함하는 의료장치들과 상기 의료장치들로 낭상혈관동맥류를 치료하기 위한 시스템 및 사용방법들에 관한 것이다. 동맥류의 루멘 내에 위치되고 수축될 수 있으며 동맥류의 형태에 일치하도록 팽창될 수 있으며 금, 백금, 또는 은으로 구성된 볼스텐트가 기술된다. 볼스텐트의 외측 표면은 동맥류를 밀봉하고 볼스텐트를 동맥류 내의 제자리에 고정시키기 위해 볼스텐트의 벽 주위에서 벽 내에 조직 성장을 촉진하고 국소 혈전 혈성을 촉진하도록 구성될 수 있다. 또한, 볼스텐트의 벽은 약물 또는 약학적 활성 분자, 가령, 혈전형성, 세포증식, 세포외 기질 형성, 및 조직 성장을 촉진하는 분자들을 릴리스하도록 구성될 수도 있다.

dispositivo médico

Steerable guiding sheath with rack and pinion deflection mechanism

A guiding sheath has a braided layer for improved deflection characteristics and ring electrodes for electrical sensing, mapping and visualization, wherein lead wires for the ring electrodes are passed through lumened tubing position under the braided layer in a proximal portion of the guiding sheath shaft and above the braided layer in a distal portion of the guiding sheath shaft. Moreover, the hemostatic valve includes an improved friction ring with air vents to reduce the risk of air being introduced into the valve.

Microcatheter system and method therefor

A microcatheter system is disclosed which may include a microcatheter, one or more microcatheter extensions, and/or a microcatheter hub. In an embodiment, the microcatheter has a plurality of zones where the outside diameter of each zone from the distal to the proximal end has an outside diameter that is the same as or greater than the previous zone while the inside diameter is constant throughout the microcatheter length. In a further embodiment, a unique joining mechanism is employed for coupling a microcatheter to a microcatheter extension or to a microcatheter hub. In a further embodiment, the microcatheter has at least one perforation along a sidewall of the microcatheter.

Fistula flow disruptors

A device for disrupting flow through a fistula may include a woven textile having a compressed state and an expanded state. The woven textile may include, in the expanded state, a neck, a first bulb coupled to a proximal side of the neck, and a second bulb coupled to a distal side of the neck. The neck has a first braid angle. The first bulb may have a second braid angle greater than the first braid angle. The second bulb may have a third braid angle greater than the first braid angle.

Therapeutic foam

A therapeutic foam for the treatment of, inter alia, varicose veins comprises a sclerosing solution foamed with a physiological gas such as carbon dioxide, oxygen or a mixture thereof. The foam has a nitrogen content of less than 0.8%. It may be generated using a pressurized canister system incorporating a fine mesh of micron dimensions through which the gas and sclerosing liquid are passed to make the foam. Alternatively, the foam may be generated by passing gas and solution between two syringes through a fine mesh. Techniques are described for minimizing the amount of nitrogen in a canister or syringe based product. A technique for generating and delivering foam simultaneously using a syringe based device is also disclosed.

Catheter and methods related thereto

Catheters are disclosed that are configured for insertion into the vasculature connected to the prostate gland of a male patient or uterus of a female patient. Such catheters may comprise a conduit having one or more bends. Conduits with a general U-shaped bend and a compound curve are within the scope of this disclosure Methods related to the catheters, including methods of use and methods of manufacture, are also disclosed.

Intravascular Devices, Systems, and Methods Having a Core Wire Formed of Multiple Materials

Intravascular devices, systems, and methods are disclosed. In some instances, the intravascular device is a guide wire having a core wire formed of multiple materials. For example, a sensing guide wire is provided that includes a core member having an inner section and an outer section surrounding the inner section, wherein the inner section is formed of a first material and the outer section is formed of a second material that is different than the first material; and a sensing element coupled to a distal portion of the core member. Methods of making, manufacturing, and/or assembling such intravascular devices and associated systems are also provided.

DEVICE AND METHODS FOR TRANSVASCULAR TUMOR EMBOLIZATION WITH INTEGRATED FLOW REGULATION

A catheter assembly may be provided with a catheter body and an inflatable balloon. The catheter body has a proximal end, a distal end and a balloon inflation lumen. The inflatable balloon is attachable to the distal end of the catheter body. The balloon has an inner surface that at least partially defines an interior volume. The balloon is configured such that the interior volume can be in fluid communication with the inflation lumen of the catheter body to inflate the balloon. The balloon also has a proximal surface and a distal surface. The balloon is provided with a channel that extends through the balloon. The channel is configured to provide fluid communication between the proximal surface of the balloon and the distal surface of the balloon. Other catheter assemblies and methods of use are also disclosed.

CATHETER BALLOON DRUG ADHERANCE TECHNIQUES AND METHODS

Various methods for optimizing coating of medical devices, such as balloon catheters are disclosed. One method configures catheter balloon folds based on balloon diameter and volume. Other methods include using a specifically-sized protective sheath, using a vacuum, using pressure, pulling the balloon through a coating solution, using at least one spacer or a wick between at least one fold for metering a therapeutic coating into the folds of the balloon, placing an intermediate layer between the balloon and the therapeutic coating, placing a soluble film having a therapeutic agent around the catheter balloon or inside the folds, and any combination thereof. Balloon catheters and catheter balloons having a specific folding configuration, a specifically-sized protective sheath, an intermediate layer, or a soluble film are also disclosed.

METHOD AND APPARATUS FOR TREATING ASCITES

A valve for treating ascites, the valve comprising: a body having a distal end, a proximal end and a lumen extending therebetween; at least one valve element disposed in the lumen of the body, the at least one valve element being a one-way valve element configured to permit the passage of fluid in a single direction through the lumen of the body; and at least one connection element provided on at least one of the distal end and the proximal end of the body, wherein the at least one connection element is configured to connect the body of the valve to the side wall of a blood vessel.

COMPLIANT CATHETER ADAPTER HAVING SELF-SLITTING NEEDLE

A self-slitting open lumen cannula may be used with catheter adapters to reduce manufacturing complexity and costs, as well as improve the safety of the catheter adapters against fluid leakage. The open lumen cannula may also include one or more notches to facilitate flashback visualization. The catheter adapters may further include a catheter adapter body formed of a compliant material that houses one or more compression resistant septa with at least one lumen formed by the proximal end of the needle during a self-slitting process as the catheter adapter is assembled. The compression resistant septum may also be coupled to a compression cap that imparts a radial compression force on the one or more compression resistant septa such that the at least one lumen narrows and seals when the cannula is removed.

Method as well as apparatuses for testing at least one function of a medical functional device

The invention relates to a method for testing at least one function of a medical functional device which is inserted in and connected and compressed with a medical treatment apparatus, and/or a function of this treatment apparatus, wherein between a hydraulic device or a pneumatic unit of the treatment apparatus and the functional device at least one fluid communication is established. It further relates to a detection device which is programmed and/or configured for executing the method according to the invention as well as a medical treatment apparatus which comprises at least one detection device and/or is in signal transmission or is connected for signal transmission with it, a digital storage medium, a computer program product as well as a computer program.

RAPID ASPIRATION THROMBECTOMY SYSTEM AND METHOD

An intravascular access system for facilitation of intraluminal medical procedures within the neurovasculature through an access sheath. The system includes an aspiration or support catheter having a flexible, distal luminal portion having an inner diameter defining a lumen extending between a proximal opening at a proximal end of the luminal portion and a distal opening at a distal end of the luminal portion. The catheter has a rigid spine coupled to at least the proximal end of the luminal portion and extending proximally therefrom. The system includes a dilator having a flexible, distal dilator portion sized to be received within the lumen of the luminal portion. Associated systems, devices, and methods of use are also described.

RETROGRADE ENTRY ANTEGRADE PLACEMENT FOR FEMORAL ARTERY ACCESS

A Retrograde Entry Antegrade Placement (REAP™) method and apparatus facilitate the antegrade (i.e., in the direction of blood flow) placement of endovascular devices for treatment of lower extremity arterial disease. Initially, a retrograde entry is made into the arterial system of a patient at an entry point with a curved needle, which then exits at an exit point proximal to the entry point, with a first wire then passed through the lumen of the curved needle. From the skin exit point, a Dual-Lumen Access Director (DAD) device is advanced in the antegrade direction down the first wire in a first lumen and enters the CFA 1 lumen. A second wire is passed down a second lumen in the DAD device and follows the SFA lumen in the antegrade direction. The DAD device is removed, and a standard dilator and sheath is inserted over the second wire and the endovascular treatment begins.

METHODS OF MANUFACTURING AN IMPELLER

Apparatus and methods are described including manufacturing an impeller by coupling a material to a helical elongate element, such that the helical elongate element with the material coupled thereto defines a blade of the impeller. A portion of a structure that includes the helical elongate element is dipped into the material while the material is in a liquid state. The material is dried, while the material is being supported by the at least one helical elongate element. During the drying of material, the structure is rotated about its longitudinal axis, such as to facilitate the formation of a film of the material having a substantially uniform thickness within the impeller blade. Other applications are also described.

Liquid collection container and extracorporeal circuit

A liquid collection bag (7) is used as a part of an extracorporeal circuit (1) and is connected via a tube (10) to a storage container (6) containing a priming solution. The collection container (7) collects the priming solution from the storage container (6) by a pressure differential between the pressure inside the collection container and the pressure inside the storage container. The liquid collection container (7) is a flexible bag body having a partition (74) part dividing the inside of the bag body into a first space (711) and a second space (712). In addition, a communication part (73) communicates the first space with the second space.

УСТРОЙСТВО И СПОСОБ ДОСТАВКИ ОТДЕЛЯЕМОГО МЕТАЛЛИЧЕСКОГО БАЛЛОНА

Группа изобретений относится к области медицины, а именно к способам окклюзии кровеносных сосудов и сосудистых аневризм. Способ заполнения части просвета кровеносного сосуда, аневризмы или другой сосудистой патологии с использованием металлического баллона содержит этапы: позиционирования сжатого металлического баллона в требуемом положении при помощи прикрепленного к баллону катетера; раздувания и расширения сжатого баллона с использованием текучей среды; отделения раздутого баллона от катетера и размещения баллона в требуемом положении и извлечения катетера. После отделения раздутый баллон остается в раздутом состоянии без по меньшей мере одного из: i) действия давления, которое является более высоким внутри раздутого баллона, чем снаружи раздутого баллона; или ii) присутствия клапана. В соответствии со вторым вариантом способ окклюзии кровеносного сосуда или лечения сосудистой патологии с использованием баллона, выполненного из пластичного металла, содержит этапы: позиционирования сжатого ...

БАЛЛОННАЯ КОНСТРУКЦИЯ И СПОСОБ ЕЁ ПРИМЕНЕНИЯ

Группа изобретений относится к медицинской технике, в частности к медицинскому устройству, содержащему баллонную конструкцию и доставляющий катетер для лечения мешковидных аневризм сосудистой системы. Медицинское устройство для лечения мешковидных аневризм содержит катетер и сжатую полую металлическую конструкцию, присоединенную к катетеру. Причем металлическая конструкция, когда она расширена, содержит один сегмент, имеющий стенку с внутренней поверхностью, образующей полость, и внешнюю поверхность с отверстием в стенке, которое позволяет проходить текучей среде в полость. Полость металлической конструкции и просвет катетера могут быть соединены текучей средой. Проход текучей среды из катетера в полость металлической конструкции приводит к ее расширению. Причем расширенная полая металлическая конструкция имеет значительную жесткость, чтобы оставаться в расширенном состоянии при имплантации в естественных условиях при открытом варианте осуществления и поддерживать расширенную конфигурацию ...

РАСШИРИТЕЛЬ ДЛЯ ПРОСВЕТОВ ЕСТЕСТВЕННЫХ КАНАЛОВ В ОРГАНИЗМЕ

... 1. Устройство для расширения просвета естественного канала в организме, содержащее (а) вытянутую полую трубку, имеющую просвет, проксимальный конец и дистальный конец, и (b) баллон на дистальном конце стержня, находящийся в жидкостной связи с просветом стержня, отличающееся тем, что баллон имеет цилиндрическую часть и эллипсоидальную часть, удаленную от цилиндрической части. 2. Устройство по п.1, отличающееся тем, что баллон сформирован из полиэтилена перефталата (PET) или полиамида. 3. Устройство по п.1 или 2, отличающееся тем, что дополнительно содержит резервуар для жидкости. 4. Устройство по п.3, отличающееся тем, что резервуар содержит несжимаемую жидкость. 5. Устройство по п.3, отличающееся тем, что дополнительно содержит помпу для доставки жидкости от резервуара к баллону. 6. Устройство по п.5, отличающееся тем, что помпа выполнена с возможностью доставлять жидкость от резервуара к баллону на установленной или выбираемой интенсивности подачи. 7. Устройство по п.5, отличающееся тем ...

УЛЬТРАФИОЛЕТОВЫЕ (УФ) СТЕРИЛИЗАЦИОННЫЕ КАТЕТЕРЫ И КОННЕКТОРЫ КАТЕТЕРА

УСТРОЙСТВО БЛОК-СТЕНТ И СПОСОБ ЕГО ПРИМЕНЕНИЯ

... 1. Медицинское устройство, содержащее:катетер исжатую полую металлическую конструкцию, присоединенную к катетеру, причем металлическая конструкция, когда она расширена, содержит один сегмент, имеющий стенку с внутренней поверхностью, образующей полость, и внешнюю поверхность с отверстием, определенным стенкой, которая позволяет проходить текучей среде в полость, причем полость полой металлической конструкции и полость катетера могут быть соединены текучей средой, а проход текучей среды из катетера в полость полой металлической конструкции приводит к ее расширению.2. Медицинское устройство по п.1, отличающееся тем, что форма расширенной металлической конструкции цилиндрическая, с плоскими или изогнутыми противоположными концами.3. Медицинское устройство по п.1, отличающееся тем, что стенка металлической конструкции содержит материал, выбранный из группы, состоящей из золота, платины, серебра, их сплавов и их сочетаний.4. Медицинское устройство по п.1, отличающееся тем, что металлическая ...

АППАРАТ ДЛЯ ПРОМЫВАНИЯ ПРИСПОСОБЛЕНИЯ ДЛЯ УДАЛЕНИЯ ТРОМБОВ, ОРГАНИЗОВАННЫЙ ПО ТИПУ ДВУСТОРОННЕГО СОСУДА

... 1. Аппарат для промывания приспособления для удаления тромбов, организованный по типу двустороннего сосуда, характеризующийся тем, что данный аппарат включает жидкостную впускную трубу, жидкостную выпускную трубу, первый насос, второй насос, первый сосуд и второй сосуд; первый сосуд выполнен с возможностью соединения с полостью высокого давления аппарата для аспирации остатков в приспособлении для удаления тромбов через жидкостную впускную трубу и первый насос, тогда как полость низкого давления аппарата для аспирации остатков соединена со вторым сосудом через жидкостную выпускную трубу и второй насос.2. Аппарат по п. 1, характеризующийся тем, что первый участок гибкой трубы для смягчения волн давления, образуемых первым насосом, установлен на жидкостной впускной трубе между первым насосом и полостью высокого давления аппарата для аспирации остатков, а второй участок гибкой трубы для смягчения волн давления, образуемых вторым насосом, установлен на жидкостной выпускной трубе между полостью ...

HEIZVORRICHTUNG

Hohlfasermembran mit periodischer Querschnittsänderung

Die vorliegende Erfindung betrifft eine Hohlfaser (8) mit einer Hohlfaserwand (14) aus einer semipermeablen Membran vorzugsweise zur Verwendung in einem Filtermodul (1) für eine Blutreinigungsmaschine, vorzugsweise Dialysemaschine, wobei die Hohlfaser (8) in deren Längserstreckung eine Anzahl von Änderungen (10, 12) zumindest in deren Außendurchmesser aufzeigt.

DILATATOR FOR A BODY CHANNEL

CONTRAST MEDIA INJECTOR

Implantable infusion device with advanceable and retractable needle

An infusion device for a drug delivery system comprises an infusion needle (1) having a tip end (2) and a drive unit (D) coupled to the infusion needle and arranged for advancing the tip end of the infusion needle to penetrate any fibrosis when the infusion device is implanted in a patient's body. The infusion needle and drive unit are designed for implantation in a patient's body. Other components of the drug delivery system may be part of the implantable infusion device or, alternatively, be for extracorporal use cooperating with the implanted infusion device. Preferably, the infusion needle can be advanced and retracted with each infusion cycle. Furthermore, upon each advancement and/or retraction, the needle may be moved laterally so as to vary the injection site. Needle (1 ) and drive unit (D) are preferably disposed within a body (15), with the infusion needle being arranged for penetrating a self-sealing penetration membrane (18).

Intravenous catheter apparatus

The invention relates toan intravenous catheter apparatus comprising a catheter hub arranged at a proximal end of a catheter tube, the catheter hub having an inner surface defining a chamber; a needle having a needle tip at its distal end and extending through the chamber and the catheter tube when in a ready position; and a needle guard slidably arranged on the needle and received in the chamber when the needle is in its ready position, wherein the needle guard is configured to guard the needle tip upon withdrawal of the needle from the catheter hub.

Ballstent device and methods of use

What is disclosed are medical devices comprising a rounded, thin-walled, expandable metal structure ("ballstent") and a flexible, elongated delivery device ("delivery catheter") and systems and methods of use for treating saccular vascular aneurysms with the medical devices. Ballstents comprised of gold, platinum, or silver that can be compressed, positioned in the lumen of an aneurysm, and expanded to conform to the shape of the aneurysm are disclosed. The external surface of ballstents can be configured to promote local thrombosis and to promote the growth of tissue into and around the wall of the ballstent in order to seal the aneurysm and fix the ballstent in place in the aneurysm. The wall of the ballstent can also be configured to release drugs or pharmacologically active molecules, such as those that promote thrombosis, cell proliferation, extracellular matrix deposition, and tissue growth.

Balloon catheter with expandable shaft

A balloon catheter comprises a shaft extending in a longitudinal direction and adapted for expanding from a compressed condition to an expanded condition in the longitudinal direction, the shaft supporting at least one radiopaque identifier, and an inflatable balloon positioned along the shaft, the balloon when inflated including a working surface for aligning with the radiopaque identifier in at least the expanded condition of the shaft. Related aspects are also disclosed.

Renal pump

Apparatus and methods are described including identifying a subject as suffering from a condition selected from the group consisting of: cardiac dysfunction, congestive heart failure, reduced renal blood flow, increased renal vascular resistance, arterial hypertension, and kidney dysfunction. In response thereto, blood pressure within a renal vein (32) of the subject is reduced, by placing a blood pump (150) inside the subject's renal vein and activating the impeller to pump blood from the renal vein into the subject's vena cava (26). Other applications are also described.

System for re-entering a vessel lumen

This disclosure is directed to systems and methods for re-entering the true lumen of a vessel. The re-entry catheters employ deflectable struts to stabilize 5 and support the distal tip in a subintimal location while a passageway back into the true lumen is formed. Re-entry to the true lumen can be effected with a cutting element or with a conventional guidewire. 11027683_1 (GHMatters) P104369.AU.2 18".. 24 _20 12 10 24 ' 20 FIG. 520 24 ...

Cannula with light-emitting optical fiber

A catheter device to visually identify a blood vessel may include a cannula. The cannula may include a distal tip, an elongated tubular shaft, and an inner lumen formed by the elongated tubular shaft. The cannula may also include an optical fiber, which may be disposed within the inner lumen of the cannula. The optical fiber may include a distal end and a proximal end. The optical fiber may be configured to emit light from the distal end.

Apparatus for detecting cells in circulating bloodstream

A device for the real-time ...

System for re-entering a vessel lumen

This disclosure is directed to systems and methods for re-entering the true lumen of a vessel. The re-entry catheters employ deflectable struts to stabilize and support the distal tip in a subintimal location while a passageway back into the 5 true lumen is formed. Re-entry to the true lumen can be effected with a cutting element or with a conventional guidewire. 18151007_1 (GHMatters) P104369.AU.4 ...

DELIVERY SYSTEM AID AND ASSOCIATED SYSTEMS AND METHODS

An endoluminal delivery system including an introducer sheath, a delivery catheter configured to pass through the introducer sheath, an endoluminal device releasably maintained along the delivery catheter at a delivery profile, and a guidewire tube removably received by the endoluminal device, the guidewire tube including an enlarged feature configured to prevent insertion of the guidewire tube into a body of a patient.

DEVICES, SYSTEMS AND METHODS TO REMOVE BLOOD CLOTS

Systems, devices and methods for removing a blood clot (10) from a blood vessel (12). Various uses of suction pressure and positive pressure, proximal and/or distal to the blood clot (10) assist with clot dislodgement and removal. The pressure(s) may be constant and/or cycled/pulsed to assist with clot dislodgement and/or removal. Various further devices assist with separating the clot (10) from the vessel (12).

Systems and methods for engaging heart tissue

A system for engaging heart tissue includes an engagement catheter defining a first lumen therethrough and having a suction port at or near a distal end and a vacuum port at or near a proximal end, a delivery catheter defining a delivery catheter lumen therethrough and configured for slidable insertion into the first lumen of the engagement catheter, and an implantable device capable of insertion into the delivery catheter lumen such that at least part of the implantable device extends from a delivery catheter distal end upon implantation into a patient, where the suction port is operable to removably attach to a targeted tissue on an interior wall of a heart of the patient after the engagement catheter has been advanced through a blood vessel and into the heart, thereby forming a reversible seal with the targeted tissue when a vacuum source is operatively coupled to the vacuum port.

Long Catheter Infusion Insertion Method and Apparatus

A long catheter can be inserted into a patient while eliminating the need for a sterile field by incorporating the long catheter into an infusion tubing and carrying it in with the infusion. The long catheter has a structure that prevents it from leaving the infusion set when fully extended and therefore becomes a connector for fluids to transfer down the long catheter by infusion through the infusion set. Use of an adjustable seal connector allows the catheter to be stopped at varying points during insertion and even to allow the catheter to be reversed by pulling suction on the infusion set and retracting the catheter back into the tubing. This also remains within the sterile confines of the infusion set and therefore is prevented from becoming contaminated.

Systems and methods for vacuum-assisted regeneration of damaged tissue

A system and method for regenerating damaged or necrosed tissue. Negative or vacuum pressure is applied to a surface of the damaged tissue to stimulate the revascularization of the area and/or increased blood flow to the area, which encourages the regeneration of the damaged tissue. A negative pressure device is provided that is capable of providing a sequenced vacuum treatment regimen to damaged tissue.

Medical probe with fluid rotary joint

A catheter is provided that includes an external sheath, a rotatable conduit housed within the external sheath, and a fluid rotary joint having a rotatable insert that places an inner lumen of the rotatable conduit in fluid communication with an external port under rotation of the rotatable conduit. The rotatable insert may include a channel structure including an external annular channel. The rotatable conduit is received within the channel structure such that the inner lumen is in fluid communication with the external port through the annular channel under rotation. The external sheath may define an outer lumen that may be in fluid communication with the inner lumen at a location remote from a proximal portion of the catheter, and the outer lumen may be in fluid communication with a secondary port. The rotatable conduit may be housed within a torque cable that is connected to the rotatable insert.

Expandable catheter system for fluid injection into and deep to the wall of a blood vessel

A catheter-based/intravascular fluid injection system with application to renal denervation includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic and/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable delivery system includes expandable components that facilitate positioning of a multiplicity of injection needles against the inside wall of a blood vessel from where they can be advanced. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel.

Management of patient fall risk

Methods, computer systems, and computer-storage media are provided for facilitating the management of a patient's fall risk. It is determined that the patient has previously been classified as a fall risk. Inputs are automatically received from fall risk sensors located in the patient's clinical care room, and, based on the inputs received from the fall risk sensors, it is determined that the patient is currently at risk for falling. Alerts are initiated and settings for components within the clinical care room are adjusted to decrease the patient's fall risk.

Endoluminal delivery of anesthesia

Described herein are methods and devices for selectively applying fluids (particularly anesthetics) to a target tissue from within a blood vessel while minimizing the amount of fluid applied to non-target tissue. The injection catheters described herein may include an elongate body, a directional injector, and one or more holdfasts for securing the catheter before extending the injector. The methods of selectively applying anesthetic to a target structure generally include the steps of inserting an injection catheter into a body vessel, positioning the injection catheter within the body vessel near the target structure, anchoring the injection catheter before extending a directional injector from the injection catheter, and applying anesthetic from the injection catheter to the target structure.

Retrograde cardioplegia delivery catheter and method for inducing cardioplegic arrest

A retrograde delivery catheter includes at its distal end an expandable member configured to at least partially occlude the coronary sinus of a patient's heart, and has a length and variable stiffness that allows the distal end to be selectively articulated so as to be positioned in the coronary sinus. The delivery catheter has a triple lumen construction with a primary lumen extending between the proximal and distal ends and configured to allow a cardioplegic fluid to be delivered to the coronary sinus. A second lumen provides for balloon inflation while a third lumen allows monitoring of a pressure within the coronary sinus. A torque may be applied and a reinforcement member within the delivery catheter provides improved torque transmission along the length of the catheter.

Apparatus and methods for filling a drug eluting medical device via capillary action

Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

Blockstent device and methods of use

What is disclosed is a medical device comprising a compressed, cylindrical or oblong, thin-walled, expandable metal structure (a “blockstent”) and a flexible, elongated device (a “delivery catheter”) to position the compressed blockstent into the lumen of a blood vessel segment to be treated, and methods of use for occlusion of treated blood vessel segments. A blockstent can be made with ductile metals such as gold, platinum, or silver such that the blockstent will conform to the shape of the lumen of the treated blood vessel segment during expansion and allow for the shape of the blockstent to be permanently changed by the application of an external force. The surface of the blockstent can be configured to promote local thrombus on the external surface of the blockstent and to promote the growth of tissue into the wall of the blockstent in order to occlude the treated blood vessel and fix the blockstent in place. The wall of the blockstent can also be configured to release drugs or pharmacologically active molecules such as those that promote thrombosis, cell proliferation, extracellular matrix deposition to promote this thrombus formation and tissue growth.

Coronary artery catheter and engaging method therefor

A coronary artery catheter adapted for introducing its distal end into a coronary ostium through an artery includes a catheter body with a lumen formed therein. The catheter body in a natural state includes: a proximal straight section extending distally from a proximal end of the catheter body; a first curved section extending distally from the proximal straight section while being curved; an intermediate straight section extending distally from the first curved section; a second curved section extending distally from the intermediate straight section while being curved; and a distalmost section extending from the second curved section to a distal end of the catheter body. The first curved section and the second curved section, when projected onto a plane on which the first curved section and the intermediate straight section are present, curve in the same direction.

Magnetic sensors and related systems and methods

This invention relates generally to magnetic sensors and related systems and methods. In some aspects of the invention, a magnetic sensor assembly includes a housing configured to releasably hold a medical fluid tube and a sensor secured to the housing, the sensor configured to detect a change in a strength of a magnetic field when a medical fluid passes through the medical fluid tube.

Endovascular ventricular assist device, using the mathematical objective & principle of superposition

This embodiment suggests new approach for Endovascular Ventricular Assist Device, using the mathematical objective & principle of superposition allow design and calculation of the body response to VAD pump located in the Aorta. This new approach allows minimal invasive Endovascular VAD that result in similar relief to the heart as partial VAD. Using special power transfer technique will allow wireless power transformation into the aorta. This methods and technique should dramatic reduce VAD barrier

Apparatus and Method for Cardiac Tissue Modulation by Topical Application of Vacuum to Minimize Cell Death and Damage

A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.

Pressure Sensing Ventricular Assist Devices and Methods of Use

The invention generally relates to heart pump systems. In some embodiments, a pressure sensor is provided with a heart pump, either at the inflow or the outflow of the blood pump. The heart pump may further include a flow estimator based on a rotor drive current signal delivered to the rotor. Based on the rotor drive current signal, a differential pressure across the pump may be calculated. The differential pressure in combination with the pressure measurements from the pressure sensor may be used to calculate pressure on the opposite side of the pump from the pressure sensor. In some embodiments, the pressure sensor is located at the outflow of the pump and the pump is coupled with the left ventricle. The differential pressure and pressure measurement may be used to calculate a left ventricular pressure waveform of the patient. With such a measurement, other physiological parameters may be derived.

SOFT CYLINDRICAL TORQUE TOOL FOR MEDICAL DEVICES WITH LUMEN

The present disclosure is related to a device for gripping catheters that are used in interventional cardiac procedures without causing internal catheter damage. The present disclosure will allow the operator to maintain improved stability and maneuverability compared with current approaches, including, primarily, digital manipulation, which can lead to fatigue, instability and inappropriate catheter movement. Specifically in the pediatric population where small movements can lead to severe and permanent complications, the present disclosure has the potential to increase the safety profile of already high-risk interventional catheterization and electrophysiology procedures. 1. An apparatus for controlling a cylindrical medical device , comprising:a bottom component having a working channel and one or more fingers comprising a sliding track, each of the one or more fingers having a top surface, a side surface, and a bottom surface; anda top component having one or more slots corresponding to the one or more fingers comprising the sliding track, the top component being slidable along the sliding track, whereinthe sliding track comprising gradations along the top surface of each of the one or more fingers, said gradations allowing the top component to reversibly slide in a step-wise manner from a rearward end of the apparatus to a forward end of the apparatus,the sliding track is declined from the rearward end of the bottom component to the forward end of the bottom component, a distance from a bottom surface of each of the one or more fingers to a surface of the working channel decreasing, accordingly, along a working axis of the bottom component, andthe top component, upon being slid along the sliding track from the rearward end of the apparatus to the forward end of the apparatus, is frictionally engaged with the cylindrical medical device, said cylindrical medical device being secured therein.2. The apparatus according to claim 1 , wherein the bottom component ...

ARTIFICIAL-BLOOD-VESSEL CONNECTOR AND ARTIFICIAL-BLOOD-VESSEL UNIT

An artificial-blood-vessel connector includes: a connector portion which includes a first cylindrical body portion where a male threaded portion and a flat surface portion where the male threaded portion is not formed are alternately formed along a circumferential direction of an outer peripheral surface, and a second cylindrical body portion to be fitted inside an artificial blood vessel; a ferrule which includes a cylindrical portion to be fitted on an outer peripheral surface of the second cylindrical body portion by way of the artificial blood vessel by being made to slide linearly on a surface of the artificial blood vessel, and a pawl plate portion in contact with the flat surface portion of the first cylindrical body portion; and a nut threadedly engageable with the male threaded portion of the first cylindrical body portion in a state where the nut covers the ferrule. 1. An artificial-blood-vessel connector for connecting an artificial blood vessel to an object to be connected by being mounted on the artificial blood vessel , wherein assuming a side of the artificial-blood-vessel connector which faces the object to be connected as a front side , a side of the artificial-blood-vessel connector opposite to the front side as a rear side , and a direction along which a center axis of the artificial blood vessel extends as an axial direction , the artificial-blood-vessel connector comprises:a connector portion which includes: a first cylindrical body portion where a male threaded portion and a flat surface portion where the male threaded portion is not formed are alternately formed along a circumferential direction of an outer peripheral surface; and a second cylindrical body portion which is formed on a rear-side end portion of the first cylindrical body portion, has an outer diameter smaller than an outer diameter of the first cylindrical body portion, and is configured to be fitted into the inside of the artificial blood vessel;a ferrule which includes: a ...

SYSTEMS, APPARATUSES, AND METHODS FOR GUIDE WIRE DELIVERY

An apparatus includes a first catheter defining a first longitudinal axis and a first lumen. A first actuator can be coupled to the first catheter and configured to rotate about the first longitudinal axis to deflect a distal end of the first catheter relative to the first longitudinal axis. A second catheter can define a second longitudinal axis and a second lumen. At least a portion of the second catheter can be configured to slide within the first lumen. A magnetic member can be coupled to a distal end of the second catheter. The magnetic member can define a third lumen. The third lumen can be in fluid communication with the second lumen. A second actuator can be coupled to the second catheter and configured to move linearly along the second longitudinal axis so as to vary a spacing between the magnetic member and the first catheter. 1. An apparatus , comprising:a first catheter defining a first longitudinal axis and a first lumen therethrough;a first actuator coupled to the first catheter and configured to rotate about the first longitudinal axis to deflect a distal end of the first catheter relative to the first longitudinal axis;a second catheter defining a second longitudinal axis and a second lumen therethrough, wherein at least a portion of the second catheter is configured to slide within the first lumen;a magnetic member coupled to a distal end of the second catheter, the magnetic member defining a third lumen therethrough, wherein the third lumen is in fluid communication with the second lumen; anda second actuator coupled to the second catheter, the second actuator configured to move linearly along the second longitudinal axis so as to vary a spacing between the magnetic member and the distal end of the first catheter.2. The apparatus of claim 1 , wherein the first catheter includes a first port in fluid communication with the first lumen claim 1 , and the second catheter includes a second port in fluid communication with the second lumen.3. The ...

Bio-Compatible Catheter

A bio-compatible lumen bearing device such as a catheter formed of a polymeric material having a titanium surface bonded to the underlying exposed catheter surface. The titanium surface is employed in patients to improve bio-compatibility and enhance lubricity during insertion and removal.

ENHANCED FLEXIBILITY NEUROVASCULAR CATHETER WITH TENSILE SUPPORT

A neurovascular catheter having an angled distal tip has an elongate flexible tubular body with a proximal end, a distal end and a side wall defining a central lumen. The side wall has a helical coil. A tubular jacket surrounds the helical coil, and extending distally beyond the helical coil distal end to terminate in a catheter distal face. A tubular radiopaque marker is embedded in the tubular jacket in between the distal end of the coil and the distal face. The distal face resides on a plane which crosses a longitudinal axis of the tubular body at an angle within the range of from about 35 degrees to about 55 degrees. The marker has a proximal face that is approximately perpendicular to the longitudinal axis and a distal face that resides on a plane which crosses the longitudinal axis at an angle within the range of from about 35 degrees to about 55 degrees. 1. (canceled)2. An enhanced flexibility neurovascular catheter comprising:a proximal end;a distal end;a side wall defining a central lumen, a distal zone of the side wall comprising a helical coil and a distal face on the distal end, the distal face residing on a plane that crosses a longitudinal axis of the neurovascular catheter at an angle, wherein the angle is at least about 55 degrees and at most about 65 degrees; a plurality of tubular segments, a proximal tubular segment of the plurality of tubular segments having a durometer of at least about 60 D, a distal tubular segment of the plurality of tubular segments having a durometer of at most about 35 D, and', 'a tubular radiopaque marker being distal to the helical coil, the radiopaque marker comprising at least one axially extending slit; and, 'an outer jacket comprisinga filament being positioned the side wall, the filament extending axially from the distal end and towards the proximal end, the filament comprising a length of at least about 10 cm and at most about 50 cm, the filament being configured to resist elongation of the side wall when under ...

Producing a Guidewire Comprising a Position Sensor

A method for producing a guidewire, the method includes producing a position sensor by providing a shaft-section having a solid profile, which is sized and shaped to move in an anatomical material transportation system. A wire is wound around an axis of the shaft-section and first and second ends of the wire are coupled to respective first and second locations on an outer surface of the shaft-section. A guidewire-shaft is provided, and the position sensor is coupled to a distal end of the guidewire-shaft. 1. A method for producing a guidewire , the method comprising: providing a shaft-section having a solid profile, which is sized and shaped to move in an anatomical material transportation system; and', 'winding, around an axis of the shaft-section, a wire, and coupling first and second ends of the wire to respective first and second locations on an outer surface of the shaft-section; and, 'producing a position sensor byproviding a guidewire-shaft, and coupling the position sensor to a distal end of the guidewire-shaft.2. The method according to claim 1 , and comprising producing the wire by cutting a wire-section from a continuous wire.3. The method according to claim 1 , wherein providing the shaft-section comprises cutting the shaft-section from a continuous shaft.4. The method according to claim 1 , and comprising moving the shaft-section by conducting at least one of: (i) moving the shaft-section along a direction parallel to the axis claim 1 , and (ii) rotating the shaft-section about the axis.5. The method according to claim 4 , wherein winding the wire comprises a sequence of operations consisting of: (i) coupling the first end to the first location claim 4 , (ii) moving the shaft-section claim 4 , and (iii) coupling the second end to the second location.6. The method according to claim 1 , and comprising claim 1 , prior to winding the wire claim 1 , coating the outer surface of the shaft-section with an electrically insulating biocompatible material.7. The ...

APPARATUS, SYSTEMS, AND METHODS FOR HIS BUNDLE LEAD PLACEMENT

Apparatus, systems, and methods are provided for placing pacing leads or other devices within a patient's heart. In an exemplary embodiment, the apparatus includes a tubular member comprising a flexible distal portion defining a curvilinear shape in a relaxed state including a curved first region defining a first radius lying within a first plane, a substantially straight second region extending from the first curved region defining a first length, and a curved third region extending from the second region defining a second radius smaller than the first radius. 1. An apparatus for delivering a lead or other secondary device into a patient's heart , comprising:an elongate tubular member comprising a proximal end, a distal end sized for introduction into a patient's body, and a lumen extending therebetween,wherein the tubular member comprises a flexible distal portion defining a curvilinear shape in a relaxed state including a curved first region defining a first radius lying within a first plane, a substantially straight second region extending from the first curved region defining a first length, and a curved third region extending from the second region defining a second radius smaller than the first radius.2. The apparatus of claim 1 , wherein the third region extends out of the first plane.3. The apparatus of claim 1 , wherein the second radius of the third region lies within a second plane orthogonal to the first plane.4. The apparatus of claim 1 , wherein the tubular member terminates at a distal tip configured for placement against a wall of the patient's heart such that an outlet communicating with the lumen is positionable against the wall.5. The apparatus of claim 4 , further comprising a pair of electrodes on the distal end on opposite sides of the outlet.6. The apparatus of claim 5 , further comprising a processor coupled to the pair of electrodes for processing signals to identify when the distal tip is placed against a desired location of a wall of the ...

Guidewire access sleeve

An access sleeve can be attached to a medical device having first and second ends, the first end being positioned inside of a patient and the second end being positioned external to a patient. The access sleeve can include a tubular sleeve body having first and second open ends that define a first lumen extending along a longitudinal axis of the sleeve body. An opening in the sleeve body can connect the first lumen to an outer surface of the sleeve body. The access sleeve can be selectively attached to the medical device (e.g. catheter of a heart pump) and inserted into the access site when the medical device is positioned in the patient. The access sleeve can maintain vascular access to a patient's access site such as an arteriotomy and can be removed without disturbing the position of the medical device.

SYSTEM AND METHOD FOR CORRECTING VALVE REGURGITATION

A method for improving function of a cardiac valve in a patient, the cardiac valve having at least one leaflet that is attached to a papillary muscle: Inserting a balloon, that is in a first uninflated condition and having a first diameter, within tissue that is part of to the papillary muscle, and thereby separating tissue that was previously connected together, by a maximum amount equal to the first diameter; inflating the balloon to a second inflated condition having a second diameter greater than the first diameter, thereby permanently stretching tissue in the papillary muscle and separating the tissue from the first diameter to a maximum amount equal to the second diameter; deflating the balloon to the first uninflated condition, and thereby returning the tissue to a separation of a maximum amount substantially equal to the first diameter; and then removing the balloon from the patient. 1. A method for improving function of a cardiac valve in a heart of a patient , the cardiac valve having at least one leaflet that is attached to a papillary muscle , the method comprising the steps of:inserting an expandable device, that is in a first unexpanded condition and having a first diameter, within tissue that is part of the papillary muscle and thereby, separating tissue that was previously connected together, by a first distance;expanding the expandable device to a second expanded condition having a second diameter greater than the first diameter, thereby permanently stretching tissue in the papillary muscle and separating the tissue by a second distance greater than the first distance;unexpanding the expandable device to the first unexpanded condition, and thereby returning the tissue to a separation of a third distance substantially equal to the first distance; and thenremoving the expandable device from the patient.2. The method of claim 1 , wherein inserting an expandable device includes inserting a balloon claim 1 , and expanding the expandable device includes ...

Implantable device for the locationally accurate delivery and administration of substances into the pericardium or onto the surface of the heart

The present invention relates to a device for the administration of substances onto the epicardial surface of the heart. The device comprises a frame structure which is able to assume shaping, positioning, guiding and stabilizing functions. The frame structure may contain at least one sleeve. The device comprises a substance carrier which is able to accommodate the substance to be administered.

SELF-CONTAINED HEART PUMP, AND METHOD IMPLEMENTED IN SUCH A PUMP

A heart pump includes: 1. A Heart pump configured to be inserted partly into a systemic ventricle of a heart , through a wall of the heart , the heart pump comprising:a housing configured to be positioned inside the systemic ventricle in such a way as to draw up blood inside the systemic ventricle and to discharge the blood inside the systemic ventricle and through its sigmoid valves of the systemic ventricle,an impeller configured to be inserted inside the housing,a motor connected to the housing,a sealing and fixing membrane fastened to and around the motor and configured to secure the heart pump to the wall of the heart and to partly arrange the motor outside the systemic ventricle,a management unit comprising a power supply, and an impeller control unit; anda wired link between the management unit and the impeller.2. Heart pump according to claim 1 , wherein the sealing and fixing membrane is circular thereby being configured to ensure a complete seal and secure the heart pump to the bottom part of the heart near the apex of the heart.3. Heart pump according to claim 1 , wherein the impeller is of the rotative type and comprises a propeller shaft arranged in the housing.4. Heart pump according to claim 1 , wherein the impeller is of the rotative type and comprises an Archimedes screw or “worm” shaft arranged in the housing.5. Heart pump according to claim 1 , wherein the housing is a longilinear cylinder claim 1 , a side wall of which is perforated in such a way as to enable a discharge of drawn blood claim 1 , and an axis of rotation of which is facing corresponding sigmoid valves.6. Heart pump according to claim 1 , wherein the management unit is biocompatible and is configured to be positioned inside the patient in the epigastric region.7. Heart pump according to claim 1 , wherein at the motor is removable.8. Heart pump according to claim 1 , wherein the power supply comprises at least one rechargeable battery.9. Heart pump according to claim 1 , further ...

THROMBUS ASPIRATION WITH DIFFERENT INTENSITY LEVELS

Vascular treatment devices and methods include a woven structure including a plurality of bulbs that may be self-expanding, a hypotube, for example including interspersed patterns of longitudinally spaced rows of kerfs, and a bonding zone between the woven structure and the hypotube. The woven structure may include patterns of radiopaque filaments measureable under x-ray. Structures may be heat treated to include various shapes at different temperatures. The woven structure may be deployable to implant in a vessel. A catheter may include a hypotube including interspersed patterns of longitudinally spaced rows of kerfs and optionally a balloon. Laser cutting systems may include fluid flow systems. 1. A system for facilitating aspiration of a thrombus in a vessel , the system comprising:an automated motor pump configured to facilitate aspiration of the thrombus, the automated motor pump comprising an external control panel configured to receive input from an operator; andpower electronics configured to power and control the automated motor pump to generate a plurality of suction patterns having a plurality of intensity levels, a first intensity level having a first negative pressure between 100 and 350 mm Hg;', 'a second intensity level having a second negative pressure between 351 and 550 mm Hg; and', 'a third intensity level having a third negative pressure between 551 and 769 mm Hg; and, 'wherein the plurality of intensity levels compriseswherein a first crescendo suction pattern of the plurality of suction patterns comprises a repetitive cycle comprising the first intensity level for a first duration, the second intensity level for a second duration after the first duration, and the third intensity level for a third duration after the second duration.2. The system of :wherein the first duration, the second duration, and the third duration are each between 1 and 30 seconds; andwherein a total duration of the repetitive cycle of the first crescendo suction pattern ...

THROMBUS ASPIRATION USING AN OPERATOR-SELECTABLE SUCTION PATTERN

Vascular treatment devices and methods include a woven structure including a plurality of bulbs that may be self-expanding, a hypotube, for example including interspersed patterns of longitudinally spaced rows of kerfs, and a bonding zone between the woven structure and the hypotube. The woven structure may include patterns of radiopaque filaments measureable under x-ray. Structures may be heat treated to include various shapes at different temperatures. The woven structure may be deployable to implant in a vessel. A catheter may include a hypotube including interspersed patterns of longitudinally spaced rows of kerfs and optionally a balloon. Laser cutting systems may include fluid flow systems. 1. A system for facilitating aspiration of a thrombus in a vessel using an operator-selectable suction pattern , the system comprising:an automated motor pump configured to facilitate aspiration of the thrombus, the automated motor pump comprising an external control panel configured to receive input from an operator; andpower electronics configured to power and control the automated motor pump to generate a plurality of variable suction patterns having a plurality of intensity levels, a first intensity level having a first negative pressure; and', 'a second intensity level having a second negative pressure,', 'wherein the first negative pressure is between 551 and 769 mm Hg, and', 'wherein the first negative pressure is more negative than the second negative pressure;, 'wherein the plurality of intensity levels compriseswherein a first variable suction pattern of the plurality of variable suction patterns comprises a repetitive cycle comprising the first intensity level for a first duration and the second intensity level for a second duration after the first duration,wherein the first duration and the second duration are each between 1 and 30 seconds, andwherein a total duration of the repetitive cycle of the first variable suction pattern is between 1 minute and 15 ...

GUIDE EXTENSION CATHETER

Guide extension catheters and related methods are disclosed. A guide extension catheter can comprise an elongate tube member, a push member, and an external manipulation member. The push member can be eccentrically coupled relative to the tube member and extend proximally therefrom for slidably positioning the tube member within and partially beyond a distal end of a guide catheter. The manipulation member can be coupled to a proximal end of the push member, where the manipulation member can be configured to secure the guide extension catheter in place during use by attaching to an external object such that the tube member and push member remain stationary without user engagement. 1. A guide extension catheter for use with a predefined length guide catheter including a continuous lumen having a cross-sectional inner diameter , the guide extension catheter comprising:an elongate tube member having a circular cross-section having a cross-sectional outer diameter sized to be insertable through the cross-sectional inner diameter of the guide catheter's continuous lumen and defining a coaxial lumen having a cross-sectional inner diameter through which an interventional cardiology device is insertable;a push member that is rigid enough to allow the tube member to be advanced through the guide catheter, the push member being proximal of and operably connected to the elongate tube, the push member having a maximal cross-sectional dimension at a proximal portion that is smaller than the cross-sectional outer diameter of the tube member and having a length that, when combined with the length of the tube member, is longer than the guide catheter, such that when at least a distal portion of the tube member is extended distally of a distal end of the guide catheter, at least a portion of the proximal portion of the push member extends proximally through a hemostatic valve in common with the interventional cardiology device insertable through the coaxial lumen of the tube member; ...

GUIDE EXTENSION CATHETER

Guide extension catheters and related methods are disclosed. A guide extension catheter can comprise an elongate tube member, a push member, and a removable support member. The push member can be eccentrically coupled directly or indirectly to the elongate tube member and can extend proximally therefrom for slidably positioning the elongate tube member within and partially beyond a distal end of a guide catheter. The removable support member can comprise a structure that surrounds at least a portion of the push member. The removable support member alone, or when placed over the push member, can be more rigid along its longitudinal axis than the elongate tube member and can have a cross-sectional 1. A guide extension catheter for use with a guide catheter , the guide extension catheter comprising:an elongate tube member having a cross-sectional outer diameter sized to be insertable through a cross-sectional inner diameter of the guide catheter and having a cross-sectional inner diameter defining a coaxial lumen through which an interventional cardiology device is insertable;a push member that is proximal of and operably connected to the elongate tube member, the push member having a maximal cross-sectional dimension that is smaller than the cross-sectional outer diameter of the elongate tube member and having a length that, when combined with the length of the elongate tube member, is longer than the guide catheter, such that when at least a distal portion of the elongate tube member is extended distally of a distal end of the guide catheter, at least a portion of the proximal portion of the push member extends proximally through a hemostatic valve in common with the interventional cardiology device; anda removable support member surrounding at least a portion of the push member, the removable support member comprising a structure that, when surrounding the push member, is more rigid along its longitudinal axis than the elongate tube member.2. The guide extension ...

Bendable Sheath and Delivery System Using Bendable Sheath

A bendable sheath and a delivery system using the bendable sheath. The bendable sheath comprises a tube body (). The tube body () comprises a distal end and a proximal end. A tube wall of the tube body () is connected to a pull wire (). One end of the pull wire () extends towards the proximal end of the tube body (), and the other end is connected to the tube body () near the distal end of the tube body (). The pull wire () comprises at least a section thereof disposed freely outside the tube body () and near the distal end of the tube body (). The pull wire () in the bendable sheath comprises the section disposed freely outside the sheath tube body () and, when pulled, the section is disposed so as to facilitate the application of force. The section moves relative to the tube body (), such that a force application point is adaptively changed. The present invention improves the safety and flexibility of operations when there is a large bending radius, or when using long, hard, or inflexible intervention apparatuses. 181-. (canceled)82. A bendable delivery system for an implantable valve , comprising:a bendable sheath, comprising a tube and a pull wire, wherein the tube has a distal end and a proximal end, and the distal end of the tube is configured to be bent by the pull wire, and wherein one end of the pull wire extends towards the proximal end of the tube, a connection portion of the other end of the pull wire and the tube is located at or adjacent to the distal end of the tube, and at least one section of the pull wire is configured as a movable section which is movable outside of the tube; the tube comprises a first section at the distal end for accommodating an implantable instrument, and a connection section connected to the first section and extending towards the proximal end;a sheath core arranged in the bendable sheath, and an operating handle connected to proximal ends of the bendable sheath and the sheath core; wherein a proximal end of the pull wire is ...

DRAINAGE OR INFUSION CATHETER AND METHOD OF USE

A drainage or infusion catheter and methods of use are disclosed. In one embodiment, the catheter includes a tube body having a proximal end and a distal end, and a plurality of ports arranged along the tube body from the distal end to the proximal end. The distal end of the tube body is configured to deform around itself into a substantially spiral shape so as to cover at least one of the plurality of ports located near the proximal end of the tube body. In another embodiment, a flap is configured to erupt from apertures arranged in the tube and extend outwardly around the tube body so as to cover at least one of the plurality of ports located near the proximal end of the tube body. 1. A method for inserting a drainage or infusion catheter into a cavity of a subject comprising: a tube body defining a passageway therethrough, the tube body having a proximal end and a distal end, and a non-deformed central region extending between the proximal end and the distal end; and', 'a plurality of ports arranged along the tube body from the distal end to the non-deformed central region, the plurality of ports extending into the non-deformed central region;', 'wherein the distal end of the tube body is deformed around the non-deformed central region in a 3D shape so as to surround at least one of the plurality of ports located in near the non-deformed central region of the tube body;, 'providing a catheter comprisinginserting an introducer within the tube body of the catheter such that the 3D shape at the distal end is straightened;inserting the catheter into the cavity; andremoving the introducer from the catheter such that when the introducer is removed, the distal end of the tube body re-forms into the 3D shape.2. The method of further comprising attaching the catheter to an external drainage or infusion apparatus claim 1 , or to a shunt-valve system.3. The method of in which the cavity comprises a ventricle and the drainage catheter drains cerebral spinal fluid.4. The ...

MEDICINE INJECTION CATHETER AND MEDICINE INJECTION SYSTEM

A medicine injection catheter includes: a catheter main body formed with a medicine supply lumen; a tubular body connected to the distal end of the catheter main body and having a lumen communicating with the medicine supply lumen; an injection needle connected to the tubular body; a tubular cover member that accommodates the tubular body and that is configured to be advanced and retracted in the axial direction of the catheter main body between a first position where a distal end of the injection needle is accommodated in the tubular cover and a second position where the distal end of the injection needle protrudes forward from the inside space; a closing member to close and open the lumen of the tubular body, a motion conversion mechanism which converts advancing/retracting motion of the cover member into movement of the closing member to close the lumen of the tubular body. 1. A medicine injection catheter for injecting medicine through a wall of a living body , the medicine injection catheter comprising:an elongated catheter main body extending in an axial direction, the catheter main body possessing a distal end and including a medicine supply lumen;a tubular body connected to the distal end of the catheter main body, the tubular body including a lumen communicating with the medicine supply lumen;an injection needle connected to a distal end of the tubular body, the injection needle possessing a distal end;a tubular cover member that includes an inside space in which is accommodated at least the tubular body, the tubular cover member being disposed at a distal end portion of the catheter main body and being configured to undergo advancing/retracting motion along the axial direction of the catheter main body to move between a first position in which the distal end of the injection needle is accommodated in the inside space and a second position in which the distal end of the injection needle protrudes distally beyond the distal end of the catheter main body and ...

Saccular Cavopulmonary Assist Device

The present disclosure relates to a saccular cavopulmonary assist device, including a shell, an inflow tube () and an outflow tube (), wherein a blood storage cavity (A) and a power cavity (B) are arranged in the shell, and the power cavity (B) is used for providing contraction and relaxation power for the blood storage cavity (A); the inflow tube () is arranged at a position corresponding to the power cavity (B) on the shell, an outer end is used for communicating with the vena cava, and an inner end communicates with the blood storage cavity (A) after passing through the power cavity (B); the outflow tube () is arranged at a position corresponding to the blood storage cavity (A) on the shell, an outer end is used for communicating with the pulmonary artery, and an inner end communicates with the blood storage cavity (A). This device can assist the cavopulmonary circulation of the single ventricle, realize repeated blood drawing and pumping actions, provide the required power for the pulmonary circulation of the patient, and restore the biventricular blood flow in the human body; and because the arrangement of the inflow tube in the power cavity, the internal structure of this device is more compact, the overall shape is smaller, and the energy of the power cavity can be fully utilized. 1. A saccular cavopulmonary assist device , comprising:a shell with a blood storage cavity (A) and a power cavity (B) separate from each other, and the power cavity (B) is configured to provide contraction and relaxation power for the blood storage cavity (A);{'b': 6', '6', '6, 'an inflow tube () arranged on a part of the shell defining the power cavity (B), wherein an outer end of the inflow tube () is configured to communicate with a vena cava, and an inner end of the inflow tube () communicates with the blood storage cavity (A) after passing through the power cavity (B); and'}{'b': 4', '4', '4, 'an outflow tube () arranged on a part of the shell defining the blood storage cavity ...

INTRA-ABDOMINAL PRESSURE TO PROMOTE HEMOSTASIS AND SURVIVAL

Systems, methods and kits for treating hemorrhages within cavities are provided. The methods utilize the application of a rapid spike of pressure to the closed cavity, followed by a steady state pressure or pressures. 1. A method of treating a hemorrhage within a cavity , comprising the steps of:applying a pressure to an interior boundary of the cavity, wherein the pressure is characterized by a transient peak value and at least one steady state value.2. The method of claim 1 , wherein the transient peak value less than about 84 mmHg.3. The method of claim 1 , wherein the transient peak value is at least about 51 mmHg.4. The method of claim 1 , wherein the transient peak value is at least about 20 mmHg5. The method of claim 1 , wherein the steady state value is at least about 28 mmHg.6. The method of claim 1 , wherein the steady state value is at least about 14 mmHg.7. The method of claim 1 , wherein the transient peak value occurs within the first three minutes and is followed by the steady state value.8. The method of claim 7 , wherein the steady state value is at least 30% of the transient peak value.9. The method of claim 7 , wherein the steady state value is at least 50% of the transient peak value.10. The method of claim 7 , wherein the steady state value is at least 90% of the transient peak value.11. The method of claim 1 , wherein the pressure is applied by an article placed into the cavity.12. The method of claim 11 , wherein the article is a foam claim 11 , which is formed inside of the cavity by applying a formulation comprising at least one liquid phase into the cavity.13. The method of claim 1 , wherein the cavity is an abdominal cavity claim 1 , a junctional hemorrhage claim 1 , a cavity associated with a pelvic hemorrhage claim 1 , or a pseudocavity.14. A kit for treating hemorrhage in a cavity of a patient claim 1 , the kit comprising:a formulation comprising at least one liquid phase, the formulation configured to form a foam when disposed into the ...

Method and System for Controlled Hyperthermia

An improved system and methods for treatment of cancer and other diseases including complications from late-stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed. The method can also be effective in treating rheumatoid arthritis, scleroderma, hepatitis, sepsis, the Epstein-Barr virus, and patients with life threatening complications from other viruses, including the COVID-19 virus. A method for removing viruses from the blood supply in an external circuit is also presented. An adjunct of the present invention is enhanced production of stem cells as a result of employing the HEATT process. A further adjunct is production of transgenic swine with extant viral infections. 1. An improved method for inducing hyperthermia in a patient , said method comprising:a. slowly withdrawing a portion of blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit;b. passing water or another heat exchange medium through a heat exchanger to heat the blood;c. slowly heating blood passing through the extracorporeal circuit at a rate in the range from 0.05° C./min to 0.15° C./min in order to prevent vascular collapse until a target body core temperature in the range from 41.8° C. to 42.2° C. is achieved;d. maintaining the blood ...

GEL DELIVERY CATHETERS, SYSTEMS, AND METHODS

An injection catheter system is disclosed. The system includes a catheter defining a first pressure transfer lumen adapted to retain a pressure transfer material, an actuator at a proximal end of the catheter adapted to deliver a pressure from a proximal end to a distal end of the first pressure transfer lumen via the pressure transfer material, a distal section defining at least a first internal chamber adapted to retain a therapeutic gel component, at least a first plunger retained in the first internal chamber, and an injection port for delivering a therapeutic gel component into a treatment location from the first internal chamber when the actuator is used to deliver a pressure via the pressure transfer material to move the first plunger to deliver a therapeutic gel component through the injection port. 1. An injection catheter system comprising:(a) a catheter defining at least a first pressure transfer lumen adapted to retain a pressure transfer fluid;(b) an actuator at a proximal end of the catheter adapted to deliver a pressure transfer fluid into a proximal end of the first pressure transfer lumen;(c) a distal section at a distal end of the catheter defining at least a first internal chamber adapted to retain a therapeutic gel component;(d) at least a first plunger retained in the first internal chamber, a proximal end of the plunger being in fluid communication with the first pressure transfer lumen and adapted to move within the first internal chamber; and(e) an injection port for injecting a therapeutic gel component into a treatment location from the first internal chamber when the actuator is used to deliver a pressure transfer fluid into the first pressure transfer lumen to move the first plunger to deliver a therapeutic gel component through the injection port.2. The injection catheter system of claim 1 , wherein the distal section further defines a second internal chamber adapted to retain a second therapeutic gel component.3. The injection catheter ...

DIAPHRAGM PUMPS FOR MEDICAL APPLICATIONS

Apparatus and methods described include a pump, which includes a piston, a diaphragm coupled to the piston and defining a wall of a fluid chamber, and a snail cam. The snail cam is configured to, by rotating, alternatingly (i) pump fluid from the fluid chamber, and (ii) draw fluid into the fluid chamber, by driving the piston to move the diaphragm. Other embodiments are also described. 1. A pump , comprising:a piston;a diaphragm coupled to the piston and defining a wall of a fluid chamber; anda snail cam configured to, by rotating, alternatingly (i) pump fluid from the fluid chamber, and (ii) draw fluid into the fluid chamber, by driving the piston to move the diaphragm.2. The pump according to claim 1 , wherein the snail cam is configured to claim 1 , when rotating at a constant speed claim 1 , alternatingly (i) pump fluid from the fluid chamber at a first rate claim 1 , and (ii) draw fluid into the fluid chamber at a second rate that is greater than the first rate.3. The pump according to claim 1 , wherein the snail cam is configured to claim 1 , when rotating at a constant speed claim 1 , during each rotational cycle of the snail cam claim 1 , (i) pump fluid from the fluid chamber for a first amount of time claim 1 , and (ii) draw fluid into the fluid chamber for a second amount of time that is less than the first amount of time.4. The pump according to claim 3 , wherein a ratio of the first amount of time to the second amount of time is at least 4:1.5. The pump according to claim 1 , wherein the snail cam is shaped to define a tooth having a slope of between 50 and 80 degrees.6. The pump according to claim 1 , wherein the snail cam is shaped to define a plurality of teeth.7. The pump according to claim 1 , wherein claim 1 , over a majority of a circumference of the snail cam claim 1 , a rate of increase of a radius of the snail cam is constant.8. Apparatus claim 1 , comprising:a piston;a diaphragm coupled to the piston and defining a wall of a fluid chamber;a ...

Vein Scanner with User Interface

A portable vein viewer apparatus may be battery powered and hand-held to reveal patient vasculature information to aid in venipuncture processes. The apparatus comprises a first laser diode emitting infrared light, and a second laser diode emitting only visible wavelengths, wherein vasculature absorbs a portion of the infrared light causing reflection of a contrasted infrared image. A pair of silicon PIN photodiodes, responsive to the contrasted infrared image, causes transmission of a corresponding signal. The signal is processed through circuitry to amplify, sum, and filter the outputted signals, and with the use of an image processing algorithm, the contrasted image is projected onto the patient's skin surface using the second laser diode. Revealed information may comprise vein location, depth, diameter, and degree of certainty of vein locations. Projection of vein images may be a positive or a negative image. Venipuncture needles may be coated to provide visibility in projected images. 1. A vein imaging apparatus , for use in imaging veins of a patient and for locating the veins for a medical practitioner by projecting the vein image onto the patient's skin surface , said vein imaging apparatus comprising:a first laser configured to emit at least a first wavelength of light;one or more optical detectors, said one or more optical detectors each configured to be responsive to said at least a first wavelength of light, and to receive a contrasted vein image formed by reflected light at said first wavelength, and to convert said image into a signal;a second laser configured to emit at least a second wavelength of light, being different than said at least a first wavelength of light;a user interface board comprising: electronic circuitry; a display screen; one or more buttons; a memory; and firmware, said firmware configured to display a menu screen list of two or more configuration settings, and parameters for each of said two or more configuration settings, on said ...

Implantation Of A Transapical Ventricular Assist Device And Kit For Same

A method of implanting a blood pump in a heart of a mammalian subject includes maintaining a temporary plug in an inlet opening of a pump having a pump body and an outlet cannula projecting from the pump body, advancing the pump into a ventricle of the heart through a hole in a wall of the heart so that the inlet of the pump is disposed within the ventricle and the outlet cannula extends through a valve of the heart into an artery, and then withdrawing the temporary plug from the inlet of the pump.

VENTRICULAR ASSIST DEVICE FOR INTRAVENTRICULAR PLACEMENT

The present invention, in one embodiment, is a blood pump for intraventricular placement inside a heart of a mammalian subject including a rigid elongate member having a length between proximal and distal ends and a bore extending along the length, an anchor element connected towards the proximal end of the rigid elongate member and mounted to the subject's heart, a pump having an inlet and an outlet, a rotor and at least one electric drive coil for magnetically driving the rotor, the pump connected at or adjacent to the distal end of the rigid elongate member remote from the anchor element and wiring extending through the bore to the pump, wherein the proximal end of the rigid elongate member extends past the anchor element to a position outside of the subject's heart. Additional embodiments of a blood pump, and various methods of intraventricular placement inside a heart of a mammalian subject are also considered.

Method and System of Utilizing ECG Signal for Central Venous Catheter Tip Positioning

Disclosed herein are a method and a medical system for utilizing of a intravascular ECG signal for central venous catheter placement. The medical system is capable of detecting the position of a catheter tip and assessing its location relative to the cavoatrial junction. The detection and assessment are performed by a multiscale analysis of the complexity of the intravascular signal data points.

MEDICINE INJECTING CATHETER AND MEDICINE INJECTING SYSTEM

A medicine injecting catheter includes a catheter body having a medicine supply lumen, a tubular body coupled to a distal end of the catheter body and having a lumen fluidly communicating with the medicine supply lumen, an injection needle connected to a distal end of the tubular body, a cover member having an interior housing the tubular body, with the cover member disposed on the distal end of the catheter body for reciprocating axial movement between a first position in which the distal end of the needle is in the inner space and a second position in which the distal end of the needle projects forwardly from the inner space, and an opening/closing mechanism for opening/closing the tubular body lumen depending on an angular position of an operating member, and a motion converting mechanism for converting reciprocating movement of the cover member into rotary movement of the operating member. 1. A medicine injecting catheter for injecting medicine into a wall of a living body , the medicine injecting catheter comprising:an elongate catheter body extending in an axial direction, the catheter body possessing a distal end and including a medicine supply lumen extending in the catheter body;a tubular body connected to the distal end of the catheter body, the tubular body including a lumen in fluid communication with the medicine supply lumen;an injection needle connected to the distal end of the tubular body, the injection needle possessing a distal end;a hollow cover member that includes an inner space in which is accommodated at least the tubular body, the cover member being disposed on a distal end portion of the catheter body for reciprocating movement along the axial direction of the catheter body between a first position in which the distal end of the injection needle is housed in the inner space and a second position in which the distal end of the injection needle projects forwardly from the inner space;an opening and closing mechanism that includes an operating ...

Intravascular devices, systems, and methods having drive cables with a lubricious coating and/or radiopaque markers

Rotational intravascular ultrasound (IVUS) imaging devices and systems are provided. The IVUS imaging devices include catheters having a rotating drive cable with a transducer disposed at a distal end thereof for imaging a bodily vessel of interest. In some embodiments, a lubricious coating is applied on the drive cable to promote uniform rotation of the drive cable and the transducer. In some embodiments, the drive cable is coated with a polymer layer to promote uniform rotation of the drive cable and the transducer. In some embodiments, radiopaque markers are affixed on the drive cable for accurate placement of the transducer within of the vessel and for accurate measurement of internal dimensions and lesion lengths within the body of the patient.

BALLOON DEVICES AND METHODS FOR USE

Balloon catheters and methods are provided for selectively occluding blood flow into a right atrium of a patient's heart communicating with an inferior vena cava (IVC) and superior vena cava (SVC). In one embodiment, a catheter includes first and second balloons adjacent one another on a distal end of the catheter shaft. During use, the distal end is introduced into the right atrium and positioned such that the first balloon is located within the right atrium. The first balloon is expanded within the right atrium and the catheter shaft directed such that the expanded first balloon engages at least a portion of the IVC to prevent substantial inflow into the right atrium from the IVC. The second balloon is then expanded to limit inflow into the right atrium from the SVC, and a medical procedure is performed within the patient's body. 1. A balloon catheter for selectively occluding blood flow into a right atrium of a heart communicating with an inferior vena cava (IVC) and superior vena cava (SVC) , comprising:an elongate shaft comprising a proximal end, a distal end sized for introduction into a patient's body, and first and second inflation lumens extending between the first and second ends;a first balloon carried on the distal end formed from compliant or semi-compliant material, the first balloon having a first length;a second balloon carried on the distal end adjacent the first balloon formed from semi-compliant or non-compliant material, the second balloon having a second length longer than the first length; anda hub on the proximal end comprising first and second ports communicating with the first and second inflation lumens, respectively, the first inflation lumen communicating with an interior of the first balloon and the second inflation lumen communicating with an interior of the second balloon, such that the first and second balloons are independently expandable by introducing inflation media into the first and second ports.2. The balloon catheter of claim ...

Endovascular ventricular assist device, using the mathematical objective & principal of superposition

This embodiment suggests new approach for Endovascular Ventricular Assist Device, using the mathematical objective & principle of superposition allow design and calculation of the body response to VAD pump located in the Aorta. This new approach allows minimal invasive Endovascular VAD that result in similar relief to the heart as partial VAD. Using special power transfer technique will allow wireless power transformation into the aorta. This methods and technique should dramatic reduce VAD barrier

SYSTEM AND METHOD FOR CARDIAC DIALYSIS

A system and method for treating a patient may include implanting an apparatus that includes a tube housing a one-way valve and having first and second surfaces. When the apparatus is implanted, the first surface is located inside the right atrium of the patient and the second surface is located on the skin of the patient. When implanted, the apparatus is used for drawing blood from the right atrium and/or providing a liquid to the patient. The apparatus may be designed to be hermetically sealed when disconnected from input and output lines. 1. A method of treating a patient , the method comprising:placing, in the right atrium of the patient, a device including at least one one-way valve; andusing the device for drawing blood from the right atrium, treating the blood and providing a liquid to the patient.2. The method of claim 1 , wherein the device is implanted in the right atrium and designed to be hermetically sealed when disconnected from input and output lines.3. The method of claim 1 , wherein the device includes:a conduit designed to house the one-way valve; andat least one elastic ring mounted on the conduit and adapted to hold the conduit in place.4. The method of claim 1 , wherein the device includes:a conduit designed to house the one-way valve; andfirst and second surfaces mounted on the conduit and adapted to hold the conduit in place by applying pressure on the patient's skin and on the inner wall of the right atrium.5. The method of claim 4 , comprising:accessing the right atrium of the heart through an anterior chest wall of the patient, using a percutaneous needle;deploying a plurality of suture mounted anchors into the right atrium of the heart, through the percutaneous needle;anteriorly drawing the right atrium of the heart towards the anterior chest wall;inserting the device into the right atrium of the heart along a guidewire;adjusting the distance between the first and second surfaces;tightening locking the first and second surfaces in place; ...

RAPID ASPIRATION THROMBECTOMY SYSTEM AND METHOD

An intravascular access system for facilitation of intraluminal medical procedures within the neurovasculature through an access sheath. The system includes an aspiration or support catheter having a flexible, distal luminal portion having an inner diameter defining a lumen extending between a proximal opening at a proximal end of the luminal portion and a distal opening at a distal end of the luminal portion. The catheter has a rigid spine coupled to at least the proximal end of the luminal portion and extending proximally therefrom. The system includes a dilator having a flexible, distal dilator portion sized to be received within the lumen of the luminal portion. Associated systems, devices, and methods of use are also described. 1. A method of performing a medical procedure at a treatment site in a cerebral vessel of a patient , the method comprising: a catheter having a catheter lumen and a distal end; and', 'an inner member, having a lumen, extending through the catheter lumen, wherein a tapered distal end of the inner member extends distal to the distal end of the catheter forming an assembled coaxial system of devices; and, 'assembling a coaxial system of devices, the coaxial system of devices comprisingadvancing the assembled coaxial system of devices together within the petrous portion of the internal carotid artery while a guidewire is not present in the lumen.2. The method of claim 1 , further comprising removing the inner member after the catheter is placed at or near the treatment site.3. The method of claim 2 , further comprising advancing a treatment device into the catheter lumen so that the treatment device resides at or near the treatment site.4. The method of claim 2 , further comprising removing occlusive material while applying a negative pressure to the catheter lumen to capture occlusive material at claim 2 , within claim 2 , or through the distal end of the catheter.5. The method of claim 4 , wherein the step of removing occlusive material ...

CATHETER

Provided is a catheter with a novel structure which is able to allow its distal end portion to deform to curve more effectively in response to an operation from an outside. In a catheter a control lumen extending in a lengthwise direction is provided to an elongated shaft member a control wire is inserted through the control lumen a fixing part to which a distal end of the control wire is fixed is provided to the shaft member and an exposed part is provided to a distal end portion of the control wire over a predetermined length so as to be exposed through a window part provided to a peripheral wall of the control lumen to a separate internal space in the shaft member 1. A catheter comprising:an elongated shaft member including a control lumen extending in a lengthwise direction;a control wire inserted through the control lumen; anda fixing part to which a distal end of the control wire is fixed, the fixing part being provided to the shaft member, whereina window part is provided to a peripheral wall of the control lumen, andan exposed part is provided to a distal end portion of the control wire over a predetermined length, the exposed part being exposed through the window part to a separate internal space in the shaft member.2. The catheter according to claim 1 , wherein the separate internal space comprises a separate lumen extending in the lengthwise direction of the shaft member.3. The catheter according to claim 2 , wherein the separate lumen comprises a main lumen extending with a cross section larger than that of the control lumen.4. The catheter according to claim 1 , wherein the window part is provided at a position away from the fixing part of the shaft member by 10 to 50 mm.5. The catheter according to claim 1 , wherein the fixing part is provided at a position away from a distal end of the shaft member by 10 to 40 mm.6. The catheter according to claim 1 , further comprising a controller provided on a proximal end side of the control wire claim 1 , the ...

IMPLANTABLE VENOUS ACCESS PORT WITH REMOTE PHYSIOLOGICAL MONITORING CAPABILITIES

An apparatus for an implantable venous access port with remote physiological monitoring capabilities is disclosed. A system and method also perform the functions of the apparatus. In one embodiment the apparatus includes a chemotherapy access port, a plurality of sensors integrated with the chemotherapy access port, where the plurality of sensors determine one or more chemotherapy-related physiological indicators and the one or more physiological indicators include at least parameters selected from red blood cell count, white blood cell count, platelets, and/or ejection fraction. The apparatus includes a communications module integrated with the chemotherapy access port, where the communications module is configured to communicate the one or more chemotherapy-related physiological indicators to a computing device. 1. An apparatus , comprising:a chemotherapy access port;a plurality of sensors integrated with the chemotherapy access port, the plurality of sensors configured to determine one or more chemotherapy-related physiological indicators, the one or more physiological indicators comprising at least parameters selected from red blood cell count, white blood cell count, platelets, and/or ejection fraction; anda communications module integrated with the chemotherapy access port, the communications module configured to communicate the one or more chemotherapy-related physiological indicators to a computing device.2. The apparatus of claim 1 , wherein the plurality of sensors comprises a blood cell counting sensor for determining the red blood cell count claim 1 , the white blood cell count claim 1 , and/or the platelet count.3. The apparatus of claim 2 , wherein the blood cell counting sensor comprises an autofluorescence sensor configured to perform an in-vivo count of red blood cells claim 2 , white blood cells claim 2 , and platelets.4. The apparatus of claim 3 , wherein the autofluorescence sensor comprises:a source configured to generate and emit excitation ...

RENAL PUMP

Apparatus and methods are described including identifying a subject as suffering from a condition selected from the group consisting of: cardiac dysfunction, congestive heart failure, reduced renal blood flow, increased renal vascular resistance, arterial hypertension, and kidney dysfunction. In response thereto, blood pressure within a renal vein () of the subject is reduced, by placing a blood pump () inside the subject's renal vein and activating the impeller to pump blood from the renal vein into the subject's vena cava (). Other applications are also described. 1. A method comprising:identifying a subject as suffering from a condition selected from the group consisting of: cardiac dysfunction, congestive heart failure, reduced renal blood flow, increased renal vascular resistance, arterial hypertension, and kidney dysfunction; andin response thereto, reducing blood pressure within a renal vein of the subject, by placing an impeller inside the subject's renal vein and activating the impeller to pump blood from the renal vein into a vena cava of the subject.2. The method according to claim 1 , wherein activating the impeller to pump blood from the renal vein into the vena cava comprises enhancing a rate of blood flow from the renal vein into the vena cava claim 1 , without causing a substantial change in a direction of the blood flow relative to a direction of blood flow from the renal vein into the vena cava in an absence of activating the pump.3. The method according to claim 1 , wherein activating the impeller to pump blood from the renal vein into the vena cava comprises activating the impeller to pump blood from the renal vein directly into a portion of the vena cava that is adjacent to the renal vein.4. The method according to claim 1 , wherein activating the impeller to pump blood from the renal vein into the vena cava comprises activating the impeller to pump blood from the renal vein into the vena cava claim 1 , without removing blood from a venous ...

SUPPORTIVE BALLOON CATHETER

A supportive balloon catheter which may be used to assist a wire guide in advancing across a lesion which partially or totally occludes an intraluminal passage. The supportive balloon catheter is advanced over the wire guide, close to the location of the lesion. The supportive balloon catheter is then inflated, securing the position of the wire guide in the intraluminal passage. A braid on the catheter may provide additional structural support. The secured catheter restricts the movement of the wire guide advancing across the lesion, preventing kinking or deflection off the surface of the lesion. Once the wire guide has advanced across the lesion, the supportive balloon catheter or a different angioplasty may be used to clear the lesion from the intraluminal passage. 1. A support balloon catheter , comprising:a body having a proximal end and a distal end;a plurality of lumens within the body, including a first lumen for a wire guide, and at least one inflation lumen;an inflatable member located near the distal end of the body having a proximal side, a distal side, and an outer surface which defines an interior region which communicates with an opening in the at least one inflation lumen; anda braid extending proximally along the body from the proximal side of the inflatable member and distally from the opening of the inflation lumen.2. The support balloon catheter of claim 1 , wherein the braid extends distally along the body from the interior region of the inflatable member.3. The support balloon catheter of claim 1 , wherein the braid extends to the proximal end of the body.4. The support balloon catheter of claim 1 , comprising a single inflation lumen within the body claim 1 , wherein the inflation lumen encircles the first lumen.5. The support balloon catheter of claim 1 , comprising two inflation lumens within the body.6. The support balloon catheter of claim 1 , wherein the braid encircles only the first lumen and extends to the distal end of the body.7. The ...

STRAIN GAUGE FOR FLOW ESTIMATION

A pressure differential across a blood pump and/or a flow rate of blood pumped by the blood pump is estimated based at least in part on impeller thrust load. A blood pump for a circulation assist system includes a housing forming a blood flow channel, an impeller, one or more support members coupled to the housing, a sensor, and a controller operatively coupled with the sensor. At least one of the one or more support members react a thrust load applied to the impeller by blood impelled through the blood flow channel by the impeller. The sensor generates output indicative of the magnitude of the thrust load. The controller is configured to process the sensor output to estimate at least one of a pressure differential across the blood pump and a flow rate of blood pumped by the blood pump. 1. A blood pump for a circulation assist system , the blood pump comprising:a housing forming a blood flow channel;an impeller disposed within the blood flow channel;one or more support members coupled to the housing, the one or more support members reacting a thrust load applied to the impeller by blood impelled through the blood flow channel by the impeller;a sensor generating a sensor output indicative of a magnitude of the thrust load reacted by at least one of the one or more support members; and a pressure differential of the blood impelled through the blood flow channel, and', 'a flow rate of blood pumped by the blood pump., 'a controller operatively coupled with the sensor, the controller being configured to process the sensor output to estimate at least one of2. The blood pump of claim 1 , wherein the impeller is supported via one or more support bearings supported by the one or more support members and the thrust load reacted by the one or more support members is applied to at least one of the one or more support members via at least one of the one or more support bearings.3. The blood pump of claim 2 , comprising an inlet stator that includes at least one of the one or ...

Method and System of Utilizing ECG Signal for Central Venous Catheter Tip Positioning

Disclosed herein are a method and a medical system for utilizing of an intravascular ECG signal for central venous catheter placement. The medical system is capable of detecting the position of a catheter tip and assessing its location relative to the cavoatrial junction. The detection and assessment are performed by a multiscale analysis of the complexity of the intravascular signal data points. 1. (canceled)2. A medical system for placement of a central venous catheter comprising:a placement unit including an electrode usable to acquire intravascular ECG (ivECG) signal data;a multiscale complexity analysis module including software programmed for processing the ivECG signal data acquired by the electrode; anda visualization device configured to provide a visual indication of a proximity of the central venous catheter to a part of a patient's body.3. The medical system according to claim 2 , wherein the part of the patient's body is a cavoatrial junction of the patient's body.4. The medical system according to claim 2 , wherein the software of the multiscale complexity analysis module is programmed to determine at least one PxI value based on the ivECG signal data acquired by the electrode.5. The medical system according to claim 4 , wherein the visualization device is configured to provide a user with the visual indication of the proximity of the central venous catheter to the part of the patient's body based on a comparison of the at least one PxI value with a proximity threshold.6. The medical system according to claim 2 , wherein the electrode is positioned at a tip of the central venous catheter.7. The medical system according to claim 6 , wherein the electrode is attached to the central venous catheter.8. A medical system for placement of an endovascular device comprising:an electrode usable to acquire intravascular ECG (ivECG) signal data;a multiscale complexity analysis module including software, the software comprising instructions to determine at least ...

SYSTEMS, DEVICES, AND METHODS FOR ASPIRATING BIOLOGICAL MATERIAL FROM A BODY LUMEN

An intraluminal system for aspirating biological material from a lumen of a patient includes a disposable intraluminal device having a proximal portion and a distal portion. The system includes a disposable pump configured to aspirate the biological material from the lumen of the patient. The disposable pump is coupled to the proximal portion of the intraluminal device. The disposable pump comprises a pump chassis that houses: an inlet port configured to sealably attach to the proximal portion of the intraluminal device; an outlet port configured to expel the aspirated biological from the pump; and a flow controller configured to adjust a fluid flow through the pump, wherein the pump chassis is sized and shaped to be manually supported by a user. 1. An intraluminal system for aspirating biological material from a lumen of a patient , comprising:a disposable intraluminal device comprising a distal portion configured to be positioned within the lumen of the patient and a proximal portion in fluid communication with the distal portion and positioned outside of the patient; and an inlet port configured to sealably attach to the proximal portion of the intraluminal device;', 'an outlet port configured to expel the aspirated biological from the pump;', 'a flow controller configured to adjust a fluid flow through the pump;', 'an actuator;', 'a first pump chamber;', 'a second pump chamber separate from the first pump chamber; and', 'a dual displacement adapter coupled to the actuator such that the actuator is configured to drive the dual displacement adapter to pump fluid through each of the first pump chamber and the second pump chamber in an alternating fashion, and, 'a disposable pump configured to aspirate the biological material from the lumen of the patient, the disposable pump coupled to the proximal portion of the intraluminal device and comprising a pump chassis that houseswherein the pump chassis is sized and shaped to be manually supported by a user.2. The ...

Catheter having tissue-engaging device

An elongated catheter includes a tissue-engaging device configured to be urged to move and contact a first surface of the first biological wall. The tissue-engaging device extends from the distal catheter section. The tissue-engaging device is configured to be urged to puncture through the first biological wall. The tissue-engaging device is also configured to be urged to contact the first biological wall without impinging the second biological wall, after the tissue-engaging device has punctured through the first biological wall.

Medical guide element with diameter transition

Improved medical guide elements for use with dilators to be inserted into an organ or body structure of a patient, such as the kidney. The guide element includes a proximal segment and a distal segment. The diameter of the distal segment is greater than the diameter of the proximal segment. The change in diameter is abrupt, providing a discrete step transition at a point along the filament which presents a proximally-facing surface on the distal segment. When the proximal segment of the guide element is fully inserted into a dilator having a distal tip adapted for insertion into a patient, the dilator distal tip firmly abuts the proximally-facing end surface of the distal segment. The relative dimensions of the dilator tip and the discrete stepped transition of the guide element provides full shielding or over shielding of the dilator tip, thereby facilitating passage of the dilator tip along the tissue track, through the puncture hole and into the orifice.

ENDOVENTRICULAR INJECTION CATHETER SYSTEM WITH INTEGRATED ECHOCARDIOGRAPHIC CAPABILITIES

Methods of providing image-guided transendocardial injection of a therapeutic agent into a left ventricular wall of a heart. Some methods enable injections into heart tissue under visualization. The methods may include providing an endoventricular injection catheter having integrated echocardiographic capability. The endoventricular injection catheter may have an imaging core and an injection system carried on the elongated body with the imaging core. The method may include positioning the endoventricular injection catheter into the left ventricle of the heart, which inserts the imaging core into the heart. The method may also include transmitting ultrasonic energy via the imaging core, receiving reflected ultrasonic energy at the distal end, visualizing the left ventricular wall of the heart using the imaging core, identifying infarct regions of the left ventricle, and injecting a therapeutic agent into the visualized infarcted regions of the left ventricle using the injection system. 1. A method of providing image-guided transendocardial injection of a therapeutic agent into a left ventricular wall of a heart , comprising:providing an endoventricular injection catheter having integrated echocardiographic capability, the endoventricular injection catheter having an elongated body with a first housing, a second housing and a distal section positioned distal to the second housing in a longitudinal direction, the distal section having a distal end and an imaging core and an injection system carried on the elongated body with the imaging core;positioning the endoventricular injection catheter into the left ventricle of the heart, thereby inserting the imaging core into a heart;transmitting ultrasonic energy via the imaging core;receiving reflected ultrasonic energy at the distal end;visualizing the left ventricular wall of the heart using the imaging core;identifying infarct regions of the left ventricle; andinjecting a therapeutic agent into the visualized infarcted ...

BALLOON FOR IABP BALLOON CATHETER

The external surface of a balloon for IABP balloon catheter is designed to have a rough surface occupying an area of 10 to 80% both inclusive of the whole of the external surface, and a smooth surface occupying an area of 90 to 20% both inclusive thereof. The supplied balloon for IABP balloon catheter is certainly unwrapped by a predetermined balloon pressure from a driving machine, with no need to conduct any preloading process, and further which is not unwrapped before and during the insertion of the catheter even in the state that a wrapping sheath is removed. 1. A balloon for IABP balloon catheter , the balloon being fitted with a medical catheter , wherein:the external surface of the balloon for IABP balloon catheter has a rough surface occupying an area of 10 to 80% both inclusive of the whole of the external surface, and a smooth surface occupying an area of 90 to 20% both inclusive of the whole of the external surface.2. The balloon for IABP balloon catheter according to claim 1 , wherein the rough surface is dispersed in at least the whole of a location other than a substantially conic part located at the distal side or proximal side of the balloon for IABP balloon catheter.3. The balloon for IABP balloon catheter according to claim 1 , wherein the rough surface is formed only in a location other than a substantially conic part formed at the distal side or proximal side of the balloon for IABP balloon catheter.4. The balloon for IABP balloon catheter according to claim 1 , wherein the rough surface is a crepe surface claim 1 , or a grain surface.5. The balloon for IABP balloon catheter according to claim 1 , wherein the rough surface is made into any one of striped claim 1 , checkered claim 1 , dotted claim 1 , and spiral patterns claim 1 , or into a pattern of a combination thereof6. The balloon for IABP balloon catheter according to claim 1 , wherein the rough surface is formed in at least one part of the internal surface of the balloon for IABP balloon ...

CATHETER PUMP HAVING A PUMP HEAD FOR INTRODUCING INTO THE ARTERIAL VASCULATURE

A catheter pump having a rotor shaft rotatably arranged in the inner catheter for driving an expandable conveyor element provided at the pump head. The conveyor element is rotatably mounted between a. distal hearing point and a proximal bearing point, wherein the outer catheter has a sleeve section on the distal end thereof surrounding the proximal bearing point, and wherein the proximal bearing point can be moved in the axial direction relative to the sleeve section in order to expand the conveyor element, wherein the proximal bearing point comprises a bearing receiver having a rotational bearing point for a rotary head rotationally fixed to the distal end of the rotor shaft, and a force application point at an axial distance to same for a force application section provided at the distal end of the inner catheter for axially moving the proximal bearing points relative to the sleeve section. 1. A Catheter pump having a pump head for introducing into an arterial vasculature ,an outer catheter,an inner catheter arranged in the outer catheter, anda rotor shaft rotatably arranged in the inner catheter for driving an expandable conveyor element provided at the pump head, wherein the expandable conveyor element being rotatably mounted between a distal bearing point and a proximal bearing point,the outer catheter has, on the distal end thereof, a sleeve section surrounding the proximal bearing point,the proximal bearing point is movable in the axial direction relative to the sleeve section for expanding the expandable conveyor element,the proximal bearing point comprises a bearing receiver having a rotational bearing point for a rotary head rotationally fixed to the distal end of the rotor shaft, andthe proximal bearing point having a force application point at an axial distance therefrom for a force application section provided at the distal end of the inner catheter for axially moving the proximal bearing points relative to the sleeve section.2. The Catheter pump ...

Systems and Methods for Inertial Sensing for VAD Diagnostics and Closed Loop Control

A blood circulation assist system includes a ventricular assist device (VAD) and a controller. The VAD is attachable to a heart of a patient to pump blood from a ventricle of the heart into a blood vessel of the patient. The VAD includes an impeller, a motor stator operable to rotate the impeller, and an accelerometer generating an accelerometer output indicative of accelerations of the VAD. The controller controls operation of the motor stator to control rotational speed of the impeller based on the accelerometer output. 1. A blood circulation assist system , comprising:a ventricular assist device (VAD) that is coupleable to a heart of a patient to pump blood from a ventricle of the heart into a blood vessel of the patient, the VAD comprising an impeller, a motor stator operable to rotate the impeller, and an accelerometer generating an accelerometer output indicative of accelerations of the VAD; anda controller that controls operation of the motor stator to control rotational speed of the impeller based on the accelerometer output.2. The system of claim 1 , wherein the controller:processes the accelerometer output to detect a cardiac cycle timing of the heart, the cardiac cycle timing including a heart rate of the heart and a time of occurrence for each of one or more cardiac cycle events for the heart; andvaries the rotational speed of the impeller in sync with the cardiac cycle timing.3. The system of claim 2 , wherein the controller varies the rotational speed to during ventricular systole of the heart to increase a rate at which the VAD pumps blood from the ventricle to the blood vessel.4. The system of claim 3 , wherein the controller is configured to accomplish one or more of:process the accelerometer output to measure motion of a heart wall of the heart to which the VAD is attached, and detect timing of ventricular systole of the heart based on the motion of the heart wall; andprocess the accelerometer output to detect a time of occurrence of at least one ...

ASPIRATION CATHETER SYSTEMS AND METHODS OF USE

Described are methods, systems, and devices for facilitation of intraluminal medical procedures within the neurovasculature including catheters and catheter advancement elements. 1. A coaxial catheter system , the system comprising: a distal, catheter portion having a lumen and a distal end having an opening from the lumen, the lumen having an inner diameter at the distal end of at least about 0.052″; and', 'a proximal extension coupled to and extending proximally from the distal, catheter portion, the proximal extension being less flexible than the distal, catheter portion; and, 'a catheter comprising a tubular portion having an inner diameter that is at least about 0.014″ up to about 0.024″, an outer diameter, wherein the outer diameter has at least one snug point, wherein a difference between the inner diameter of the distal, catheter portion and the outer diameter of the tubular portion at such snug point is no more than about 0.010″;', 'a proximal extension coupled to and extending proximally from the tubular portion, the proximal extension being less flexible than the tubular portion; and', 'a tip portion located distal to the at least one snug point of the tubular portion, wherein the tip portion has a length and tapers along at least a portion of the length of the tip portion,, 'a catheter advancement element comprisingwherein the coaxial catheter system has an advancement configuration characterized by:a) the catheter advancement element positioned coaxially within the lumen of the distal catheter portion, wherein the at least one snug point of the tubular portion is substantially aligned with the distal end of the distal catheter portion, and a distal point of the at least three points located a distance proximal from the distal-most end of the catheter advancement element, the distal point having a first bending force that is no greater than about 0.05 Newtons;', 'an intermediate point of the at least three points located a distance proximal from the ...

System and Method of Utilizing ECG Signal for Static Catheter Tip Confirmation

Systems and methods for confirming the tip location of a static endovascular device are disclosed. The system can include an ivECG acquisition module for receiving ECG data from an implanted endovascular device and a notification module. The system can calculate P×I and distance parameters to determine the location of the tip of the implanted endovascular device relative to a predetermined location such as the cavoatrial junction. The system can use chaos theory and the concept of self-organized criticality (SOC) to determine parameters where P-waves are absent or atypical. The notification module can include one or more of an audio signal, a video signal, and a tactile signal. Also disclosed are systems and methods of establishing an electrical pathway within a previously positioned, endovascular device, including saline columns and electrically conductive guidewires. 1. A tip confirmation system for confirming a location of a tip of a static endovascular device , the system comprising:an ivECG acquisition module;a multiscale complexity analysis module;a notification module, including one or more of an audio feature, a video feature, and a tactile feature;an electrical pathway extending from a distal tip of the static endovascular device to a proximal end thereof, andan adaptor designed to couple the electrical pathway with the ivECG acquisition module,wherein the multiscale complexity analysis module uses ivECG signals, provided by the ivECG acquisition module and the electrical pathway, to provide a P×I (proximity index), the notification module indicating a location of the distal tip of the static endovascular device relative to a predetermined target location.2. The system of claim 1 , wherein the electrical pathway includes an embedded electrode extending from a proximal hub to a distal tip of the static endovascular device.3. The system of claim 1 , wherein the electrical pathway includes an electrically conductive device disposed within a lumen of the static ...

Methods for performing a coronary artery bypass graft procedure

The invention provides methods of treating an obstructive coronary artery disease in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof and performing a coronary artery bypass graft procedure on the subject.

Endovascular cerebrospinal fluid shunt

An endovascular implantable shunt device for draining cerebrospinal fluid from a patient's subarachnoid space includes a shunt having opposed first and second ends, a one-way valve located at the first end of the shunt, a tip disposed at the second end, and a hollow passageway extending between the tip and one-way valve. The tip is constructed to penetrate a patient's sinus wall. Cerebrospinal fluid drains through the tip and out through the valve.

BASKET CATHETER WITH IMPROVED SPINE FLEXIBILITY

A catheter with basket-shaped electrode assembly with spines configured for hyper-flexing in a predetermined, predictable manner when a compressive force acts on the assembly from either its distal end or its proximal end. At least one spine has at least one region of greater (or hyper) flexibility that allows the electrode assembly to deform, for example, compress, for absorbing and dampening excessive force that may otherwise cause damage or injury to tissue wall in contact with the assembly, without compromising the structure and stiffness of the remaining regions of the spine, including its distal and proximal regions. The one or more regions of greater flexibility in the spine allow the spine to flex into a generally V-shape configuration or a generally U-shape configuration. 1. A catheter comprising:an elongated catheter body having proximal and distal ends and at least one lumen therethrough; and an expander that is longitudinally moveable relative to the catheter body; and', 'a plurality of spines having proximal and distal ends surrounding the expander, at least one spine having an equatorial region of greater flexibility and proximal and distal regions of lesser flexibility, the basket-shaped electrode assembly being moveable by longitudinal movement of the expander between a collapsed configuration, an expanded configuration in which the spines bow radially outward relative to the catheter body to form a first expanded shape, and a hyper-expanded configuration in which the spines bend at the equatorial region of greater flexibility to thereby deform the first expanded shape, shorten a length of the basket-shaped electrode assembly and assume a V shape with an acute bend in the equatorial region of greater flexibility., 'a basket-shaped electrode assembly at the distal end of the catheter body, the basket-shaped electrode assembly having proximal and distal ends and comprising2. The catheter of claim 1 , wherein the at least one spine has a width dimension ...

INTRA-ABDOMINAL PRESSURE TO PROMOTE HEMOSTASIS AND SURVIVAL

Systems, methods and kits for treating hemorrhages within cavities are provided. The methods utilize the application of a rapid spike of pressure to the closed cavity, followed by a steady state pressure or pressures. 1. A kit for treating hemorrhage in a cavity of a patient , the kit comprising:a formulation comprising at least one liquid phase, the formulation configured to form a foam when disposed into the cavity; andinstructions instructing a user to perform a method of treating a hemorrhage within said cavity of the patient, said method comprising the steps of:applying a pressure to an interior boundary of the cavity, wherein the pressure is applied by an article placed into the cavity and is characterized by a transient peak value, and wherein the article is a material which is formed inside of the cavity by applying the formulation into the cavity.2. The kit of claim 1 , wherein the foam is configured to apply a pressure to an interior boundary of the body cavity claim 1 , the pressure being characterized by a transient peak value that is less than about 84 mmHg.3. The kit of claim 1 , wherein the foam is configured to apply a pressure to an interior boundary of the body cavity claim 1 , the pressure being characterized by a transient peak value that is at least about 51 mmHg.4. The kit of claim 1 , wherein the foam is configured to apply a pressure to an interior boundary of the body cavity claim 1 , the pressure being characterized by a transient peak value that is at least about 20 mmHg.5. The kit of claim 1 , wherein the foam is configured to apply a pressure to an interior boundary of the body cavity claim 1 , the pressure being characterized by a transient peak value and at least one steady state value.6. The kit of claim 1 , wherein the cavity is a human abdominal cavity.7. The kit of claim 1 , wherein the formulation is provided in a dosage ranging from 45 mL to 100 mL.8. The kit of claim 1 , wherein the formulation is provided in a dosage ranging ...

CATHETER

A catheter can efficiently transmit an operator's pushing force to a distal end of the catheter with a reduced risk of getting caught at a curved region of a lumen (e.g., a blood vessel, bile duct, pancreatic duct or the like). The catheter includes a first core wire and a second core wire disposed between an inner tube and an outer tube. The second core wire can move to an optimal position depending on external forces exerted at a curved region of the lumen when the catheter is inserted into the curved region. Therefore, there is a reduced risk that the first core wire and the second core wire will interfere with each other, which would prevent the catheter from bending along the lumen and potentially break one or both of the first core wire and the second core wire. 1. A catheter comprising:an outer tube;an inner tube disposed within the outer tube;a first core wire disposed between the outer tube and the inner tube, the first core wire being fixed to the outer tube or the inner tube; anda second core wire disposed between the outer tube and the inner tube and disposed parallel to the first core wire, the second core wire being capable of moving circumferentially around the inner tube and in an axial direction of the catheter.2. The catheter according to claim 1 , further comprising a portion in which a cross-sectional area of the second core wire is smaller than a cross-sectional area of the first core wire.3. The catheter according to claim 1 , further comprising a restriction part provided at the first core wire or the second core wire claim 1 , wherein the restriction part restricts distal movement of the second core wire.4. The catheter according to claim 3 , wherein the restriction part is provided at the first core wire and is positioned distally to a distal end of the second core wire.5. The catheter according to claim 4 , wherein the restriction part is an annular part that protrudes from the first core wire and restricts the distal movement of the second ...

OPENING SYSTEM FOR IMPROVING CATHETER DELIVERY

A ball-tipped mandrel, separate or integrated on a device delivery assembly, can be used to ease delivery and/or retrieval of an ancillary device within a body vessel having tortuous anatomy. A ball-tipped mandrel can be moved through a catheter as a part of a preparation procedure prior to insertion into a body vessel of a patient. A ball-tipped mandrel can be moved through a catheter during or after insertion into a body vessel of a patient in preparation for delivery of an ancillary device. A ball-tipped mandrel can be integrated onto the distal portion of a device to produce dilation during device delivery. 1. A method of treating a catheter , comprising:moving an enlarging member of an expander longitudinally within a lumen of a catheter, while the catheter is outside a patient, wherein an outer cross-sectional dimension of the enlarging member is (i) between 0.0002″ and 0.0006″ larger than a first inner cross-sectional dimension of the lumen in an unrestrained condition and/or (ii) between 1% and 3% larger than the first inner cross-sectional dimension of the lumen.2. The method of claim 1 , further comprising claim 1 , inserting the catheter into a body vessel of a patient.3. The method of claim 2 , wherein the inserting occurs within 1 day after the moving.4. The method of claim 2 , wherein the inserting occurs within 1 hour after the moving.5. The method of claim 1 , wherein the moving comprises passing the enlarging member from a first location distal to a distal end of the catheter to a second location proximal to a proximal end of the catheter.6. A system for treating a catheter claim 1 , comprising:a catheter having a lumen with an inner cross-sectional dimension; andan expander comprising an enlarging member having an outer cross-sectional dimension;wherein an outer cross-sectional dimension of the enlarging member is (i) between 0.0002″ and 0.0006″ larger than a first inner cross-sectional dimension of the lumen in an unrestrained condition and/or (ii ...

SHEATH FOR MAINTAINING POSITION IN A PERICARDIAL SPACE

The present invention provides a novel design for sheaths intended for medical procedures. The sheath includes structures that anchor the sheath in a cavity or space when deployed but are at the same time retractable such that the sheath can be removed without tearing the tissue defining the space. 1. A sheath for implanting a medical device or medical equipment into a body cavity of a patient , said sheath comprising:a sheath wall comprising one or more channels disposed within the sheath wall that traverse the wall from a proximal portion to a distal portion, wherein the channel(s) terminate at the distal portion of the sheath with an opening through which a distal portion of a wire anchor can be extended and retracted, and wherein the channel(s) terminate at the proximal portion of the sheath with an opening through which a proximal portion of the wire anchor can be manipulated by an operator,a wire anchor that is preformed to comprise a curve or bend that is caused to straighten when disposed within the channel(s), but allowed to reform its pre-formed curved or bent shape when not disposed within the channel(s), thus forming a wire anchor that retains the distal portion of the sheath within the body cavity by contact of the wire anchor with a body cavity surface,wherein retraction of the wire anchor into the sheath disables the anchoring function and allows removal of the sheath without tearing of the body cavity surface.2. The sheath of claim 1 , wherein the wire anchor is a single wire having a curve or bend that claim 1 , when extended from the sheath wall claim 1 , extends away from the sheath at about 10° to about 135° from the wall surface.3. The sheath of claim 2 , wherein the wire anchor extends away from the sheath at about 90°.4. The sheath of claim 1 , wherein the wire anchor comprises nitinol.5. The sheath of claim 1 , wherein the wire anchor comprises a thermoplastic or a thermoset polymer.6. The sheath of claim 1 , wherein the wire anchor is a ...

PASS-THROUGH ASSEMBLY

A pass-through assembly including a first wall having oppositely-directed inner and outer sides, the first wall defining a first opening extending from the inner side to the outer side an elongated structure extending into the opening from the outer side of the first wall ; a first material contacting the first wall and the elongated structure so as to at least partially seal the opening and a second material different from the first material the second material overlying the first material on the outer side of the wall the second material adhering to the elongated structure and the first wall the second material having at least one physical property different than a corresponding physical property of the first material 128-. (canceled)29. A pass-through assembly comprising:a first wall having an inner side and an outer side opposite the inner side, the first wall defining an opening extending from the inner side to the outer side;an elongated structure extending into the opening from the outer side of the first wall;a ring element coupled to the elongated structure, the ring element being deformable to permit insertion into the opening in an insertion direction;a first material contacting the first wall and the elongated structure so as to at least partially seal the opening; anda second material overlying the first material on the outer side of the first wall and adhering to the elongated structure and the first wall, the second material including at least one physical property different than a physical property of the first material.30. The pass-through assembly of wherein the opening includes a diameter and the ring element defines an outer diameter greater than the diameter of the opening.31. The pass-through assembly of claim 29 , wherein the elongated structure is flexible.32. The pass-through assembly of claim 31 , further comprising a plurality of openings extending from the inner side to the outer side and a plurality of elongated flexible structures ...

Blood Collection Device and Related Systems and Methods

A blood collection device to reduce hemolysis in a peripheral intravenous catheter system may include a distal end. The distal end of the blood collection device may include a male luer adapter, which may include a distal opening. The blood collection device may include a cannula in fluid communication with the male luer adapter. The cannula may include a distal end and a sharp proximal tip. The blood collection device may include an elongated neck disposed between the male luer adapter and the sharp proximal tip. The blood collection device may include a fluid pathway extending from the distal opening through the sharp proximal tip. A diameter of the fluid pathway may be constant. An entire length of the fluid pathway is represented by L, and the diameter of the fluid pathway is represented by D. D 4 /L may be equal to or less than a predetermined value.

Aspiration systems

Thrombus aspiration may be performed using manual negative intermittent suction (e.g., provided by a syringe) or using an automated negative suction device (e.g., provided by a vacuum pump). The suction device may be connected through suction tubing to a hub of a catheter. The automated negative suction device may include an external control panel for the operator configured to allow the operator to choose from any of a plurality of suction patterns during an aspiration procedure.

Methods, Assemblies, and Devices for Positioning a Catheter Tip Using an Ultrasonic Imaging System

A catheter assembly includes an elongated member having an ultrasonic beacon disposed adjacent to a distal end portion of the elongated member, a power supply releasably attachable adjacent to the proximal end of the elongated member, and a catheter. The distal end portion of the elongated member with the ultrasonic transmitter is inserted into an anatomical structure of the human body, and the ultrasonic transmitter is powered by the power supply. Using conventional medical ultrasonography equipment, a technician is able to observe and/or track on a display an image of the internal structure of the human body and an image such as an illuminated bright spot representing the energized ultrasonic beacon. After locating the elongated member, the power supply is removed, and the catheter is slid onto the elongated member to locate the catheter tip. Thereafter, the elongated member is removed. 1. A tip location system for positioning the tip of a peripherally inserted central catheter comprising:an elongated member having a proximal end portion and a distal end portion, and adapted to be inserted into a peripheral vein of a human body;a locating signal generator positioned at the distal end portion of the elongated member and operable to be powered by a power supply to generate a locating signal to be detected by a signal receiver outside of the human body;a peripherally inserted central catheter (PICC) having a proximal end portion and a distal end portion slideably receivable over the proximal end portion of the elongated member.2. The tip location system of claim 1 , wherein the locating signal generator includes at least one ultrasound transmitter.3. The tip location system of claim 2 , wherein the ultrasound transmitter includes first and second electrodes and a piezo film positioned therebetween.4. The tip location system of claim 2 , wherein the power supply includes an oscillator coupled to the ultrasound transmitter and adapted to oscillate the ultrasound ...

OPEN ELECTRIC PUMP

An implantable pump is configured to be implanted in series with blood flow from a heart. The pump includes a frame configured to be implanted within the natural blood flow of the heart such as a ventricular outflow tract an outlet valve of the heart, and a central axle configured to be affixed within the frame parallel to the blood flow. The pump also includes a rotor attached to the central axle and configured to rotate in order to pump blood, and at least two electromagnetic coils configured to be energized in order to cause the rotor to rotate. 1. An implantable pump configured to be implanted in series with blood flow from a heart , the pump comprising:a frame configured to be implanted a natural blood path of blood in the heart, including in a ventricular outflow tract of the heart or in place of outlet valves of the heart;a central axle configured to be affixed within the frame parallel to the blood flow;a rotor attached to the central axle and configured to rotate in order to pump blood; andat least two electromagnetic coils configured to be energized in order to cause the rotor to rotate.2. The implantable pump according to claim 1 , wherein the frame has at least one opening in a direction of the blood flow to allow the blood to flow without obstruction when the rotor does not rotate.3. The implantable pump according to claim 1 , wherein the at least two electromagnetic coils are positioned radial with respect to a direction of the blood flow.4. The implantable pump according to claim 1 , wherein the at least two electromagnetic coils are position perpendicular to the rotor.5. The implantable pump according to claim 1 , wherein both of the at least to electromagnetic coils are situated in the frame on a same side of the rotor.6. The implantable pump according to claim 1 , wherein a first of the at least two electromagnetic coils is situated on a first side of the rotor claim 1 , and a second of the at least two electromagnetic coils is situated on a second ...

CANNULA SYSTEM AND METHOD FOR DISCHARGING THE VOLUME OF A HEART

A cannula system for puncturing the heart is provided, comprising a cannula and a trocar. The cannula comprises a cannula shaft with a heart-side inlet and a pump-side outlet. The trocar has a trocar shaft which can be inserted into the lumen of the cannula and which comprises a puncturing tip, wherein the puncturing tip can completely cover the inlet opening of the cannula. 1. A cannula system for the puncture or volume relief of the heart , comprising a cannula and a trocar ,wherein the cannula comprises a cannula shaft with a heart-side inlet which comprises an inlet edge which delimits the inlet opening, and with a pump-side outlet and a lumen which extends between the inlet and the outlet, wherein a suture ring for connecting the cannula to the heart is arranged on an outer side of the cannula shaft and the outlet is connectable to a pump; andwherein the trocar comprises an opening for a guide wire and a trocar shaft which has a puncturing tip and is insertable into the lumen from the outlet, and the trocar shaft is longer than the lumen, so that in a puncturing configuration the puncturing tip projects out of the inlet of the cannula; andthe trocar shaft or the puncturing tip completely covers the inlet opening.2. The cannula system of claim 1 , wherein the puncturing tip comprises a peripheral sealing lip which at least partly covers the inlet edge.3. The cannula system of claim 1 , wherein the inlet edge in the axial direction to the inlet opening comprises a chamfer and the puncturing tip terminates with the inlet edge in a flush manner.4. The cannula system of claim 3 , wherein the puncturing tip is chamfered and a chamfer angle of the puncturing tip and a chamfer angle of the chamfer of the inlet edge differ from one another by less than 30°.5. The cannula system of claim 1 , wherein at least the puncturing tip of the trocar comprises an expandable cavity and the puncturing tip completely covers the inlet opening when the cavity is in an expanded state.6. ...

Vein Scanner with User Interface

An insulated bucket truck intercom facilitates safe/reliable bucket-to-cab and bucket-to-ground communications during truck operations, while in close proximity to high voltage power sources/lines. A truck-powered cab transceiver and battery-powered bucket transceiver are selectively interconnected by fiber optic cable to maintain high voltage electrical isolation of at least 10 KV/foot. A hands-free bucket transceiver liberates bucket workers from depressing a PTT button to communicate during repair operations. A PTT cab transceiver prevents stray sounds from distracting bucket workers. Bucket elevation through extension of the telescoping boom, with fiber optic cable secured thereto, is accommodated by a self-storing fiber optic reel assembly positioned at each section. Play in the cable and a spring-loaded pulley member accommodates boom articulation. A cab transceiver radio interface permits interference-free communication between the bucket transceiver and/or the cab transceiver, with a remote walkie-talkie up to 10 miles distant. A sensor warns of imminent truck tipping from boom overreaching. 1. A vein imaging apparatus , for use in imaging veins of a patient and for locating the veins for a medical practitioner by projecting the image onto the patient's skin surface , said vein imaging apparatus comprising:a first laser configured to emit at least a first wavelength of light;one or more photodiodes, said one or more photodiodes each configured to be responsive to said at least a first wavelength of light, to thereby receive a contrasted vein image formed by reflected light at said first wavelength, and to convert said image into a signal;a second laser configured to emit at least a second wavelength of light, being different than said at least a first wavelength of light;a user interface board comprising: electronic circuitry; a display screen; one or more push buttons; a memory; and firmware, said firmware configured to display a scrollable menu screen list ...

Hemostasis Mechanism And Method

A hemostasis mechanism includes a housing having a valve body, a connector coupled to a distal end of the valve body, and a cap coupled to a proximal end of the valve body. A first valve is within the housing and has a fixed state of axial compression between the valve body and the cap. A second valve is within the housing and has a range of states of axial compression between the valve body and the connector. The first valve has a self-closing bias and forms a lower pressure seal about a medical device pushed therethrough. The second valve has a self-opening bias and forms a higher pressure seal about the medical device via adjustment of its state of axial compression. 1. A hemostasis mechanism comprising:a housing including a valve body defining a longitudinal axis extending between a proximal body end and a distal body end, and including a cap coupled to the proximal body end and having a fixed axial location relative the valve body, a connector coupled to the distal body end and having an adjustable axial location relative the valve body, and a device passage formed in part in each of the valve body, cap, and connector;a first valve positioned at least partially within the device passage and having a fixed state of axial compression between the valve body and the cap, the first valve having a first opening formed therein and a self-closing bias such that the first opening is normally closed, and further forming a lower pressure seal about a medical device in response to pushing the medical device through the first opening in opposition to the self-closing bias; anda second valve positioned at least partially within the device passage and having a range of states of axial compression between the valve body and the connector, the second valve having a second opening formed therein and a self-opening bias such that the second opening is normally open, and further forming a higher pressure seal about the medical device via an adjustment of the state of axial ...

DEVICE FOR TREATING AN INDIVIDUAL SUFFERING FROM CARDIAC INSUFFICIENCY, CARDIAC ARREST, CIRCULATORY ARREST OR STROKE

The invention relates to a device for treating an individual suffering from cardiac or circulatory arrest or from a stroke, comprising a blood withdrawal device (BE) that is applied to the individual (P), an analysis unit (BA) which is directly or indirectly connected to the blood withdrawal device for detecting a blood analysis result (BAE) providing at least one characteristic of the blood, directly or indirectly connected to a blood return device (BR) that is applied to the individual (P) and is designed to deliver a substance to the individual via the return device (BR). 164-. (canceled)65. A method for providing treatment of cardiac arrest by withdrawing blood from a patient's or an animal's circulatory system during the cardiac arrest by first introducing a reperfusion solution containing at least one substance into the circulatory system and then introducing modified blood into the circulatory system formed by addition of at least one substance to the withdrawn blood to provide whole body reperfusion of the circulatory system during the treatment of the cardiac arrest comprising;{'sub': 2', '2, 'determining during treatment of the cardiac arrest a plurality of parameters of the blood including at least pO, pCOand pH representing a current condition of the patient or animal during the treatment of the cardiac arrest and providing an output representing the parameters during the treatment;'}storing during the treatment of the cardiac arrest at least two substances from which the at least one substance is selected for treatment of the cardiac arrest;{'sub': 2', '2, 'selecting, based on the determination of at least the pO, pCOand pH during the treatment of the cardiac arrest, a type and quantity of at least one substance to be withdrawn from the storage which is first added to the circulatory system and then to the withdrawn blood to form the modified blood which is introduced into the circulatory system during treatment of the cardiac arrest; and'}introducing ...

Catheter for Portable Lung Assist Device

The present invention relates to a catheter that minimizes or eliminates the recirculation of oxygenated blood. The catheter of the present invention can be used to drain blood from multiple points in the patient, namely the superior vena cava, right atrium, and the right ventricle, while returning blood to the patient's pulmonary artery. Further, the catheter of the present invention is less likely to be moved or dislodged than catheters currently available in the art, thus making the catheter particularly useful for portable lung assist devices. The present invention also relates to methods for inserting the catheter into the patient and using the catheter with a lung assist device. 1. A catheter comprising:a first tube having a proximal end, a distal end, and a length therebetween, and a lumen within the length of the first tube with at least one opening to the lumen near the distal end;a second tube having a proximal end, a distal end, and a length therebetween, and a lumen within the length of the second tube with at least one opening to the lumen at the distal end; anda preformed curvature near the distal end of the first tube and along the length of the second tube;wherein at least one of the openings of the first tube resides within the curvature, and wherein the distance of the at least one opening in the first tube residing in the curvature relative to the at least one opening in the distal end of the second tube is such that when the catheter is positioned in a subject's heart, the at least one opening in the first tube is positionable in the right ventricle while the at least one opening of the second tube is positionable in the pulmonary artery.2. The catheter of claim 1 , wherein the distal end of the second tube extends 50 to 150 mm past the most distal opening of the first tube.3. The catheter of claim 1 , wherein at least one of the openings of the first tube is positionable in the superior vena cava when the catheter is positioned in the subject's ...

Angiogram injections using electrocardiographic synchronization

An injection system is described that receives, from one or more sensors, a first group of one or more signals indicating a current volume of injection fluid dispensed from a fluid reservoir at a first time. The injection system determines, based on the first group of one or more signals, that a difference between a dispensed volume limit and the current volume of the injection fluid dispensed from the fluid reservoir at the first time is less than a necessary volume of fluid required to complete both a systolic injection phase and a diastolic injection phase. The injection system further, responsive to determining that the difference is less than the necessary volume of fluid required to complete both the systolic injection phase and the diastolic injection phase, controls the injection system to refrain from performing each of the systolic injection phase and the diastolic injection phase.

CATHETER PUMP DEVICE FOR LOCAL REDUCTION OF VENOUS PRESSURE

Various catheter systems using a patient's own bodily fluids to increase local fluid velocity and therefore localized lower pressure via the Venturi effect. Exemplary systems utilize a pump to suction and eject blood to/from an attached catheter. One catheter comprises a valve moveable such that the area of the opening at the distal end for fluid passage is larger during suction than during ejection. Another catheter comprises openings in the sidewall and a balloon at the distal end to temporarily occlude the vessel during suction. Another catheter comprises a narrow distal opening and multiple openings with valves in the catheter sidewall. When catheters are deployed near a lymphatic opening into the circulation, such as at the thoracic duct, the ejection of blood from the catheter may cause a localized pressure reduction aiding in the reintroduction of lymph into the circulation. 1. A device for reducing pressure at a veno-lymph junction to alleviate lymphatic congestion , comprising:a catheter and at least one opening at or near a distal end of the catheter having an effective area allowing the passage of fluid therethrough; anda valve having an open position and a closed position, wherein the valve at least partially blocks the at least one opening in the closed position;wherein the valve is configured to enter the closed position in response to positive pressure within the catheter and further configured to enter an open position in response to negative pressure within the catheter;wherein when the valve is in the closed position, the effective area of the at least one opening is smaller than when the valve is in the open position.2. The device of claim 1 , wherein the valve defines a small opening for the passage of fluid therethrough when the valve is in the closed position3. The device of claim 2 , wherein the valve comprises two semi-circular flaps pivotally coupled to the catheter wall at or near the center of the catheter such that in the closed position ...

INTRAVENTRICULAR PULSATING BLOOD PUMP

The invention provides an intraventricular pulsating blood pump fixedly disposed at the ventricularapex inside the ventricle to generate pulsation action. The pulsating blood pump is substantially jellyfish-shaped and includes a bell-shaped pump body and a driving source, an opening of the bell-shaped pump body faces to the outlet of the ventricle, the driving source drives the bell-shaped pump body to contract or relax, and the contraction or relaxation of the bell-shaped pump body drives the blood in the ventricle to eject directionally to the artery and form a convoluted blood flow field between the inner wall of the bell-shaped pump body and the inner wall of the ventricle. The invention not only provides assist to ventricular by pulsating blood flow, but also optimizes the flow field and pressure distribution in the ventricle, the blood pump of the invention is better in biocompatibility than the blood pumps in prior art. 1. An intraventricular pulsating blood pump , which has an open pump body to generate pulsation action and is fixedly disposed at the ventricularapex inside the ventricle , wherein the intraventricular pulsating blood pump is generally jellyfish-shaped and includes:a bell-shaped pump body, an opening of the bell-shaped pump body facing to an outlet of the ventricle; anda driving source, which drives contraction and relaxation of the bell-shaped pump body to change the volume of an inner cavity of the bell-shaped pump body, when the volume of the inner cavity is reduced, the blood in the bell-shaped pump body is pressed outwards, thereby realizing blood ejection to the ventricle, and when the volume of the inner cavity is increased, the blood outside of the bell-shaped pump body is inhaled into the bell-shaped pump body to provide blood for a next blood ejection.2. The intraventricular pulsating blood pump according to claim 1 , wherein the contraction and relaxation of the bell-shaped pump body allows the blood to produce the Venturi effect ...

METHODS FOR PERFORMING A CORONARY ARTERY BYPASS GRAFT PROCEDURE

The invention provides methods of treating an obstructive coronary artery disease in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof and performing a coronary artery bypass graft procedure on the subject. 1. A method for treating obstructive coronary artery disease comprising:{'sub': '2', '(a) administering to a mammalian subject a therapeutically effective amount of the peptide D-Arg-2′6′-Dmt-Lys-Phe-NHor a pharmaceutically acceptable salt thereof; and'}(b) performing a coronary artery bypass graft procedure (CABG) on the subject.2. The method of claim 1 , wherein the subject is administered the peptide prior to the CABG procedure.3. The method of claim 1 , wherein the subject is administered the peptide after the CABG procedure.4. The method of claim 1 , wherein the subject is administered the peptide during and after the CABG procedure.5. The method of claim 1 , wherein the subject is administered the peptide continuously before claim 1 , during claim 1 , and after the CABG procedure.6. The method of claim 5 , wherein the subject is administered the peptide for at least 3 hours after the CABG procedure.7. The method of claim 5 , wherein the subject is administered the peptide for at least 5 hours after the CABG procedure.8. The method of claim 5 , wherein the subject is administered the peptide for at least 8 hours after the CABG procedure.9. The method of claim 5 , wherein the subject is administered the peptide for at least 12 hours after the CABG procedure.10. The method of claim 5 , wherein the subject is administered the peptide for at least 24 hours after the CABG procedure.11. The method of claim 5 , wherein the subject is administered the peptide starting at least 8 hours before the CABG procedure.12. The method of claim 5 , wherein the subject is administered the peptide starting at least 5 hours before the CABG procedure.13. The method of claim 5 , ...

ASSISTANCE SYSTEM, ASSISTANCE METHOD, ASSISTANCE PROGRAM, AND RECORDING MEDIUM HAVING ASSISTANCE PROGRAM RECORDED THEREON

An assistance system includes a schedule information acquisition unit that acquires disease information on the surgery and blood vessel information relating to a shape of a portion capable of applying a backup force to the catheter by coming into contact with the catheter in a blood vessel of the patient, a past information acquisition unit that acquires a shape of a catheter used for a past similar surgery having the disease information coinciding with that of the surgery and having the blood vessel information similar to that of the surgery, and a proposal unit that corrects the shape of the catheter used for the past similar surgery, based on a comparison result obtained by comparing the blood vessel information on the surgery with the blood vessel information on the past similar surgery, and that proposes a catheter having the corrected shape, as the catheter to be used for the surgery. 1. An assistance system for assisting a doctor by proposing a shape of a catheter to be used for a surgery of a patient , the system comprising:a schedule information acquisition unit that acquires disease information on the surgery and a blood vessel information relating to a shape of a portion capable of applying a backup force to the catheter by coming into contact with the catheter in a blood vessel of the patient;a past information acquisition unit that acquires a shape of the catheter used for a past similar surgery having the disease information coinciding with that of the surgery and having the blood vessel information similar to that of the surgery; anda proposal unit that corrects the shape of the catheter used for the past similar surgery, based on a comparison result obtained by comparing the blood vessel information on the surgery with the blood vessel information on the past similar surgery, and that proposes the catheter having the corrected shape, as the catheter to be used for the surgery.2. The assistance system according to claim 1 , further comprising:a ...

DILATION PARAMETER DETERMINATION METHOD AND SYSTEM, COMPUTER AND STORAGE MEDIUM

Provided are a dilation parameter determination method and system, a computer and a storage medium. The method includes: controlling liquid to be continuously injected at a first rate into a balloon arranged in a normal blood vessel at a preset distance from a to-be-dilated blood vessel; acquiring a first liquid pressure of the balloon; determining a diameter of the normal blood vessel according to the first liquid pressure and a balloon parameter; and determining a target dilation parameter of the to-be-dilated blood vessel according to the diameter of the normal blood vessel and a preset dilation rule. 1. A dilation parameter determination method , comprising:controlling liquid to be continuously injected at a first rate into a balloon arranged in a normal blood vessel at a preset distance from a to-be-dilated blood vessel;acquiring a first liquid pressure of the balloon;determining a diameter of the normal blood vessel according to the first liquid pressure and a balloon parameter; anddetermining a target dilation parameter of the to-be-dilated blood vessel according to the diameter of the normal blood vessel and a preset dilation rule.2. The method of claim 1 , wherein determining the diameter of the normal blood vessel according to the first liquid pressure and the balloon parameter comprises:determining a pressure change rate of the balloon according to a change of the first liquid pressure;determining a critical contact moment of the balloon and the normal blood vessel according to the pressure change rate; andacquiring a first liquid volume of the balloon at the critical contact moment, and determining the diameter of the normal blood vessel according to the first liquid volume and the balloon parameter.3. The method of claim 2 , wherein determining the critical contact moment of the balloon and the normal blood vessel according to the pressure change rate comprises:acquiring a difference between a pressure change rate of the balloon at each moment and a ...

Balloon dilatation system

Provided is a balloon dilatation system, which includes a signal collecting module, a main controller, a pressurization module, a pressure relief module, a first pressure sensor, a flow rate sensor, a balloon catheter and a balloon. The signal collecting module is electrically connected to the main controller, and is configured to collect a control signal and send the control signal to the main controller; the main controller is electrically connected to the pressurization module and the pressure relief module; the pressurization module is connected to the balloon through the balloon catheter; the pressure relief module is connected to the balloon through the balloon catheter; the first pressure sensor is arranged on the balloon catheter and is configured to monitor a first liquid pressure of the balloon; the flow rate sensor is arranged on the balloon catheter and is configured to monitor a liquid flow rate of the balloon catheter.

OCCLUSION BYPASSING APPARATUS WITH VARYING FLEXIBILITY AND METHODS FOR BYPASSING AN OCCLUSION IN A BLOOD VESSEL

An occlusion bypassing apparatus is disclosed for re-entering the true lumen of a vessel after subintimally bypassing an occlusion in a vessel. The apparatus includes an outer shaft component, an inner shaft component disposed within the outer shaft component, and a needle component slidably disposed within the inner shaft component. The inner shaft component includes a body portion and a needle housing, which is distal to the body portion. The needle housing is less flexible than the body portion. In order to smooth the transition between the body portion and the needle housing, the needle housing includes a transition portion that has a variable flexibility along its length that decreases in a distal direction. A curved distal end of the needle component is distally advanced relative to the inner shaft component to pierce through the intima of the vessel and thereafter enter the true lumen. 1. An apparatus for bypassing an occlusion in a blood vessel comprising:an outer shaft component having a side port proximal to a distal end thereof; andan inner shaft component disposed within the outer shaft component and defining a continuous lumen there-through, the inner shaft component havinga body portion that extends substantially parallel with a longitudinal axis of the apparatus, anda needle housing distally extending from a distal end of the body portion, the needle housing including a curved distal portion that bends from the longitudinal axis of the apparatus and terminates at the side port of the outer shaft component and a transition portion positioned between the body portion of the inner shaft component and the distal portion of the needle housing,wherein the transition portion has a variable flexibility along its length that decreases in a distal direction; anda needle component configured to be slidably disposed within the continuous lumen of the inner shaft component and removable therefrom, the needle component having a curved distal end with the same ...

INJECTION DEVICE FOR MINIMALLY INVASIVE PROCEDURES AND USES THEREOF

Provided herein is an injection device that can be used in minimally invasive procedures, such as laparoscopic surgeries, for direct administration of a fluid, such as a therapeutic, to a target tissue or organ. 1. An injection device , comprising:a) a syringe barrel, wherein the syringe barrel provides a fluid reservoir;b) a plunger configured to be controlled by the operator of the device and to move within the syringe barrel for loading and releasing fluid from the fluid reservoir in the syringe barrel;c) an injection needle that is operably coupled to the syringe barrel providing a fluid pathway for fluid contained in the syringe barrel to be injected into a target tissue when the plunger is depressed;d) an elongate sheath, comprising an internal lumen that contains the injection needle and having a distal tip that contains an opening for the injection needle, wherein the sheath is movable around the injection needle; and a housing, comprising at least a first and second stop to control exposure of the injection needle and that are provided within the housing at a predetermined distance from each other;', 'a central lumen in the housing comprising a connection member, wherein the connection member is configured to be movable in the central lumen in the housing and is coupled to the sheath, wherein the proximal end of the sheath is coupled to the distal end of the connection member so that movement of the connection member controls movement of the sheath; and', 'a positioner mounted within the housing configured to move forward towards the distal end of the controller and rearward towards the proximal end of the controller, between the stops in the housing, wherein the positioner is operatively connected to the connection member to guide movement of the connection member in the same direction, whereby movement of the positioner forward towards the distal end engages the first stop and moves the sheath to enclose the injection needle inside the lumen of the sheath ...

DELIVERY CATHETER INCLUDING SIDE PORT AND ELECTRODES

A delivery catheter, including a catheter body, a side port, a first electrode, and a second electrode, is described. The catheter body may comprise a proximal end, a distal end, and a perimeter surface. The catheter body defines a delivery lumen extending longitudinally within the catheter body. The side port is defined in the perimeter surface of the catheter body proximate the distal end and in communication with the delivery lumen. The electrodes may be adjacent to and spaced from the side port. Techniques for using the delivery catheter to identify a desired lead implantation location, e.g., via the electrodes, and implant a medical lead or other implantable element at the desired location through the delivery lumen and side port are also described. 1. A delivery catheter comprising:a catheter body comprising a proximal end, a distal end and a perimeter surface, wherein the catheter body defines a delivery lumen extending longitudinally within the catheter body;a side port defined in the perimeter surface proximate the distal end and in communication with the delivery lumen;a first electrode; anda second electrode, wherein each of the first and second electrodes is adjacent to and spaced from the side port.2. The delivery catheter of claim 1 , wherein the first and second electrodes are both distal from the side port.3. The delivery catheter of claim 1 , wherein the first and second electrodes are both proximal from the side port.4. The delivery catheter of claim 1 , wherein the first electrode is distal from the side port and the second electrode is proximal from the side port.5. The delivery catheter of claim 1 , wherein each of the first and second electrodes are each spaced at least 2 mm from the side port.6. The delivery catheter of claim 1 , wherein the catheter body further defines a guide wire lumen.7. The delivery catheter of claim 1 ,wherein the catheter body further comprises a deflection member extending into the delivery lumen at a distal end of ...

REGIONAL DELIVERY OF THERAPEUTIC AGENTS FOR THE TREATMENT OF VASCULAR DISEASES

The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well. 1. A method of treating a vascular disease , comprising:providing a device having a regional delivery interface comprising a therapeutic agent; 'the delivery interface contacts the vessel segment surface not only at the known or suspected afflicted region but at a non-afflicted region at the periphery of the afflicted region as well; and,', 'contacting the delivery interface with a surface of a segment of a vessel that is known or suspected to include a region that is afflicted with a vascular disease, whereindelivering the therapeutic agent onto or into the vessel segment surface from the regional delivery interface in contact with the vessel segment surface.2. The method of claim 1 , wherein the regional delivery interface is about 40 mm or more in length.3. The method of claim 2 , wherein the entire length of the regional delivery interface contacts the vessel segment surface.4. The method of claim 2 , wherein two or more segments of the regional delivery interface contact the vessel segment surface provided that one or more of the regional delivery interface segments contact(s) the vessel segment surface at the afflicted regions and one or more regional delivery interface segments contact the vessel segment at the non-afflicted regions of the vessel segment.5. The method of claim 1 , wherein the therapeutic agent comprises a pharmaceutically acceptable composition.6. The method of claim 5 , wherein the pharmaceutically acceptable composition comprises a micelle claim 5 , a worm micelle claim 5 , a liposome or a polymerosome.7. The method of claim 5 , wherein the pharmaceutically acceptable composition ...

SYSTEM AND METHOD FOR CONTACTLESS POWER TRANSFER IN IMPLANTABLE DEVICES

In the field of contactless power transfer for medical devices, more specifically, to contactless power transfer for intra-corporeal medical devices, a system and method for transmitting power to a rechargeable power supply are provided, the rechargeable power supply comprising implantable power receiving means, and an implantable power storage means. The system comprises an extra corporeal power transmitting means arranged and configured to supply power to the rechargeable power supply by wirelessly transmitting power to the implantable power receiving means. The system and method are particularly useful in the context of minimally invasive procedures. 1. A system for transmitting power to a rechargeable power supply , said rechargeable power supply comprising implantable power receiving means , and an implantable power storage means ,wherein said system comprises an extra corporeal power transmitting means arranged and configured to supply power to the rechargeable power supply by wirelessly transmitting power to the implantable power receiving means.2. The system of claim 1 , wherein the power transmitting means comprises an electromagnetic coil.3. The system of claim 1 , wherein the power transmitting means and the implantable power receiving means are configured to be magnetically coupled claim 1 , thereby enabling power transmission between the extra-corporeal power transmitting means and the implantable power receiving means.4. The system of claim 2 , wherein the longitudinal axis of the electromagnetic coil is arranged and configured to be substantially parallel to the longitudinal axis of an implantable power receiving means.5. The system of claim 1 , further comprising positioning means for positioning the power transmitting means relative to the implantable power receiving means to enable magnetic coupling.6. The system of claim 5 , wherein the positioning means claim 5 , in use claim 5 , is positioned around the abdomen of a patient.7. The system of ...

PROLATE SPHEROID-SHAPED BALLOON WITH CENTRAL HINGE

An elongated, tubular-shaped balloon for a balloon catheter includes three regions along its length, in sequence: a proximal region, an intermediate region, and a distal region. The intermediate region is defined by a curved outer surface that is established by a radius of curvature r. Similarly, a curved inner surface for the intermediate region is established by a radius of curvature r, wherein r≧r. Balloon thickness at the center of the intermediate region is t, while balloon thickness in both the proximal and distal regions is t (t>t). The stretchability and bendability of the balloon material is directly proportional to the thickness of the balloon, to thereby shape the balloon as a prolate spheroid when inflated. 1. A system which comprises:an elongated shaft formed with a lumen, wherein the shaft defines a longitudinal axis, has a proximal end and a distal end, and has an outer surface;{'sub': 1', '2', '1', '2', 'c, 'a tubular shaped balloon membrane having a proximal end affixed to an outer surface of the shaft and a distal end affixed to the outer surface of the shaft to establish an inflation chamber between the balloon membrane and the outer surface of the shaft, wherein the balloon membrane has a central thickness to at the middle of an intermediate region midway between the proximal and distal ends of the membrane, wherein the intermediate region of the membrane is defined by a first arc on an outer surface of the membrane and includes a second arc on an inner surface of the membrane, wherein the first arc and the second arc are coplanar with the longitudinal axis of the shaft, wherein the first arc has a radius of curvature raround a first point on a line perpendicular to the shaft and the second arc has a radius of curvature raround a second point on the line, wherein the line intersects the shaft at a midpoint between the proximal end and the distal end of the membrane, and wherein r≧rand the intermediate region of the membrane has a thickness talong ...

ANCHOR DEPLOYMENT DEVICES AND RELATED METHODS

Described here are devices, methods, and kits for the deployment of tissue anchors. In some variations, the devices may comprise a shaft defining a lumen for housing at least one anchor therein and a mechanism for deploying the anchor distally from the lumen. In certain variations, the devices may comprise one or more stop elements. For example, a device may comprise a stop element that limits the advancement of the device through an opening in a wall portion or at the distal end of another device. 145-. (canceled)46. A method for delivering anchors comprising:advancing a guide tunnel to a subannular groove region, the guide tunnel comprising an outer catheter having a first lumen therethrough and a plurality of side openings, and an inner catheter slidably disposed within the first lumen, the inner catheter having a second lumen therethrough;positioning the inner catheter at a first side opening of the outer catheter;advancing a first anchor delivery catheter within the second lumen of the inner catheter through the first side opening of the outer catheter;deploying a first anchor from the first anchor delivery catheter into the subannular groove region;positioning the inner catheter at a second side opening of the outer catheter;advancing a second anchor delivery catheter within the second lumen of the inner catheter through the second side opening of the outer catheter; anddeploying a second anchor from the second anchor delivery catheter into the subannular groove region.47. The method of claim 46 , wherein the first and second anchor delivery catheters each comprise a tubular elongated member having a proximal end claim 46 , a distal end claim 46 , a side portion therebetween claim 46 , and an elongated wire extending from the side portion claim 46 , wherein a bend in the elongated wire signals to an operator when to stop advancing the tubular elongated member. This application is a continuation application of U.S. application Ser. No. 12/657,422, filed on Jan. ...

THERAPEUTIC INTERVENTION METHODS, DEVICES, AND SYSTEMS

Described herein are devices, systems, and methods used to assess an organ or organ system and determine a course of treatment for said organ, organ system, and/or patient. 1. A method of treating a patient , the method comprising:obtaining, in a processor, a plurality of measurements that are related to the patient;determining, via the processor, an organ demand score and an organ capacity score from the plurality of measurements;calculating, via the processor, a demand-capacity ratio using at least one of a clinical points ratio calculation, a logistic ratio calculation, a logistic additive ratio calculation, clinical index product ratio calculation, a logistic product ratio calculation, or a combination thereof;causing, via the processor, information to be displayed on a display screen that is indicative that the patient has organ failure and needs intervention when the demand-capacity ratio is in a target range; andproviding for, via the processor, an administration of organ support to the patient.2. The method of claim 1 , wherein the calculating is performed by dividing the organ demand score by the organ capacity score to provide the demand-capacity ratio.3. The method of claim 1 , wherein at least the obtaining claim 1 , determining claim 1 , and calculating steps can be repeated to provide a dynamic demand-capacity ratio.4. The method of claim 3 , wherein the steps are repeated at intervals of time.5. The method of claim 3 , wherein the dynamic demand-capacity ratio can be used to determine a change in therapy needed.6. The method of claim 1 , wherein the plurality of measurements includes at least one of a heart rate claim 1 , a blood pressure claim 1 , a cardiac output claim 1 , a urine sample claim 1 , a blood sample claim 1 , a liquid input value claim 1 , a sequential organ failure assessment score for the patient claim 1 , an INR value claim 1 , a pOvalue claim 1 , a COremoval value claim 1 , a FeV1 test value claim 1 , a pH value or a combination ...

MEDICAL GUIDEWIRE

A guidewire system may include a guidewire having a relatively stiff proximal section and a relatively flexible distal section joined by a transition region, and a TAVI device slidably disposed on the guidewire. The guidewire may include an expandable element disposed about the transition region. The expandable element may be configured to expand from a collapsed configuration to an expanded configuration. The guidewire may include an expandable element disposed at the distal end. The distal section may be pre-configured to form more than one distal loop. A method of protecting an apex of a left ventricle during a TAVI procedure may include inserting a guidewire into the left ventricle, positioning a transition region adjacent the apex, expanding an expandable element such that the expandable element spans the apex, advancing a TAVI device distally over the guidewire to an aortic valve, and performing a TAVI procedure at the aortic valve. 1. A guidewire system , comprising:a guidewire having a proximal end, a distal end, and a length extending therebetween;wherein the guidewire includes a relatively stiff proximal section and a relatively flexible distal section joined by a transition region; anda TAVI device slidably disposed on the guidewire;wherein the guidewire includes an expandable element disposed about the transition region in a first position;wherein the expandable element is configured to expand from a collapsed configuration to an expanded configuration.2. The guidewire system of claim 1 , wherein the expandable element includes an inflatable balloon.3. The guidewire system of claim 2 , wherein the guidewire includes a lumen extending through the proximal section to an inflation port opening into the inflatable balloon.4. The guidewire system of claim 2 , wherein the inflatable balloon includes a generally wide claim 2 , flat cross-section.5. The guidewire system of claim 4 , wherein the inflatable balloon includes a thin middle section extending ...

Antimicrobial compositions and uses thereof

In some aspects, provided herein are antimicrobial compositions comprising partially esterified polygalacturonic acid and certain fatty acids (e.g., caprylic acid). In some embodiments, the antimicrobial composition may be administered (e.g., topically or orally) to a subject, such as a human patient to treat an infection (e.g., an infection comprising a biofilm). In some aspects, improved catheters are provided.

Drug Delivery Medical Device

Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until implantable device is deployed a an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents. 1. (canceled)2. A medical device comprising:a balloon; anda coating on at least a portion of the balloon, the coating including a polymer and a crystalline macrolide drug present on an exterior surface of the coating,wherein actuation of the balloon releases at least 3% of the drug to a treatment site.3. The medical device of claim 2 , wherein the coating further includes a cationic binding agent.4. The medical device of claim 2 , wherein the binding agent comprises at least one of: Polyarginine claim 2 , Polyarginine 9-L-pArg claim 2 , DEAE-Dextran (Diethylaminoethyl cellulose-Dextran) claim 2 , DMAB (Didodecyldimethylammonium bromide) claim 2 , PEI (Polyethyleneimine) claim 2 , TAB (Tetradodecylammonium bromide) claim 2 , and DMTAB (Dimethylditetradecylammonium bromide).5. The medical device of claim 3 , wherein an average molecular weight of the binding agent or a size of the active agent in the coating is controlled.6. The medical device of claim 3 , wherein a ratio of the active agent to the binding agent is 1:1 claim 3 , 1:2 claim 3 , 1:3 claim 3 , 1:4 claim 3 , 1:5 claim 3 , 1:10 claim 3 , 1:20 claim 3 , 2:1 ...

Treatment Method Using Catheter Assembly and Catheter Assembly

A catheter assembly includes an outer catheter that includes a tubular outer catheter body and an outer catheter hub, and an inner catheter that includes an inner catheter body and an inner catheter hub. The inner catheter body is positionable in the outer catheter body, and the outer catheter hub is connectable to the inner catheter hub. The inner catheter body includes a shaft extending from the inner catheter hub, and a tubular body disposed at the distal end of the shaft and possessing an inner catheter lumen. When the outer catheter hub is connected to the inner catheter hub, a portion of the tubular body is distal of the distal-most end of the outer catheter body, a portion of the tubular body is distal of the proximal-most end of the outer catheter body, and a proximal end portion of the tubular body is in the outer catheter lumen. 1. A catheter assembly comprising:an outer catheter that includes a tubular outer catheter body and an outer catheter hub, the tubular outer catheter body possessing a distal-most end and a proximal-most end, the outer catheter hub possessing a proximal end, and the outer catheter hub being disposed at a proximal end of the outer catheter body;an inner catheter that includes an inner catheter body and an inner catheter hub, the inner catheter body possessing a distal-most end and a proximal end, the inner catheter body being configured to be positioned in the outer catheter body, the inner catheter hub being disposed at a proximal end of the inner catheter body, the inner catheter hub possessing an inner catheter hub lumen, the outer catheter hub being connectable to the inner catheter hub;the inner catheter body including a shaft extending from the inner catheter hub to a distal end of the shaft, and a tubular body disposed at the distal end of the shaft and possessing an inner catheter lumen which opens to outside the tubular body at both a distal portion and a proximal portion of the tubular body such that a guide wire is ...

EMBOLIC PROTECTION ACCESS SYSTEM

Methods and devices are provided for protecting the cerebrovascular circulation from embolic debris released during an index procedure. An embolic protection filter is delivered in a reduced profile configuration via an access catheter, and positioned in the aorta spanning the ostia to the three great vessels leading to the cerebral circulation. An index procedure catheter is thereafter advanced through the same access catheter to conduct the index procedure. The index procedure may be a transcatheter aortic valve replacement. 1. An embolic protection access system , comprising:a self expendable frame having a proximal end and a distal end;a filter membrane supported by the tubular body;a bare metal leading segment extending distally beyond the filter membrane; anda tubular control wire extending proximally from the tubular frame.2. An embolic protection access system as in claim 1 , wherein the proximal end resides on a plane that extends at a non-normal angle to a longitudinal axis of the frame.3. An embolic protection access system as in claim 1 , wherein the proximal end includes a plurality of eyelets.4. An embolic protection access system as in claim 3 , wherein an eyelet is formed by an apex at the junction of two struts of a wire filament.5. An embolic protection access system as in claim 3 , further comprising a suture extending through the eyelets and configured to collapse the proximal end of the filter upon proximal retraction of the suture.6. An embolic protection access system as in claim 5 , wherein the control wire comprises a central lumen claim 5 , and the suture extends axially through the central lumen.7. An embolic protection access system as in claim 1 , further comprising a tubular delivery catheter claim 1 , and the frame is carried in a reduced cross-sectional configuration within the delivery catheter.8. An embolic protection access system as in claim 7 , wherein the delivery catheter has an outer diameter of about 13.5 F.9. A method of ...