УСТРОЙСТВО ДЛЯ ЛЕЧЕНИЯ ИНДИВИДУУМА СО СНИЖЕННОЙ ФУНКЦИЕЙ СЕРДЦА, ОСТАНОВКОЙ СЕРДЦА, ОСТАНОВКОЙ КРОВООБРАЩЕНИЯ ИЛИ АПОПЛЕКСИЧЕСКИМ УДАРОМ

... 1. Устройство для лечения индивидуума с остановкой сердца или кровообращения или с апоплексическим ударом, содержащее применяемое на индивидууме (Р) средство (ВЕ) взятия крови для взятия по меньшей мере части крови у индивидуума, блок (ВА) анализа, опосредованно или непосредственно связанный со средством взятия крови, для определения и предоставления по меньшей мере одной характеристики крови в виде результата (ВАЕ) анализа крови, исполнительный блок (КЕ), который опосредованно или непосредственно связан с применяемым на индивидууме средством (BR) обратной подачи и выполненный с возможностью передачи вещества индивидууму через средство (BR) обратной подачи, отличающееся тем, что исполнительный блок (КЕ) содержит по меньшей мере один блок (R) резервуара, который создает запас по меньшей мере двух веществ (S, S, …), что предусмотрен скомбинированный с блоком (R) резервуара блок (D) дозирования, который по меньшей мере с учетом результата (ВАЕ) анализа крови, определенного блоком (ВА) анализа ...

КАТЕТЕРНОЕ УСТРОЙСТВО И СПОСОБ СОЗДАНИЯ ОТРИЦАТЕЛЬНОГО ДАВЛЕНИЯ В МОЧЕВОМ ПУЗЫРЕ ПАЦИЕНТА

BEATMUNGSSYSTEM

IMPLANTIERBARES INFUSIONSGERÄT MIT VORSCHIEBBARER UND ZURÜCKZIEHBARER NADEL

Fluid delivery system

A fluid delivery system 100 comprising a fluid source 130, a pump 120 arranged to deliver fluid from the fluid source 130 to a patient 140, a sensor 150 configured to measure a physiological parameter associated with the patient during fluid delivery, and a controller 170 configured to control operation of the pump 120. The controller 170 receives from the sensor 150 a plurality of measurements of the physiological parameter, generating curve data that is dependent on the plurality of measurements of the physiological parameter. The curve data is compared with predetermined curve data and a control signal 180 generated based on said comparison. The control signal 180 is output to the pump 120 to control the delivery of fluid from the fluid source 130 to the patient 140. The fluid to be delivered may be saline, delivered for the treatment of shock, and the physiological parameter may be cardiac output. The controller 170 may be configured to predict a fluid responsiveness of the patient, ...

DEVICE FOR THE ADMINISTRATION OF CO

IMPLANTIERBARES INFUSION EQUIPMENT WITH EXTENDABLE AND RETRACTABLE NEEDLE

PROCEDURE AND DEVICE AS THE MEASUREMENT AND A CHECK OF THE HORMONE MIRROR IN AN ANIMAL CIRCULATION SYSTEM.

Apparatus for controlled delivery of opioid and other medications

A method, system and apparatus for administering various medicaments including those for treating pain and substance dependency are disclosed. The apparatus is a unit for heat activation of a morphine opiate liquid concentrate mixed with a carrier substance to produce inhaled gas. The method includes inhaling the heat activated gaseous vapor concentrate for pain relief, to treat substance dependency or administration of other medicaments. The system includes a heat vaporization unit with security, control and communication capability to provide effective patient care and ensure safety.

Systems and methods for shunting fluid

Abstract Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system and for opening auxiliary fluid pathways through a shunt system are also disclosed ...

URETERAL AND BLADDER CATHETERS AND METHODS FOR INDUCING NEGATIVE PRESSURE TO INCREASE RENAL PERFUSION

Ureteral catheters and assemblies are provided including: a drainage lumen including a proximal portion configured to be positioned in at least a portion of a patient's urethra and a distal portion configured to be positioned in a patient's ureter and/or kidney, the distal portion including a coiled retention portion including at least a first coil having a first diameter and a second coil having a second diameter, the first diameter being less than the second diameter; or wherein the retention portion extends radially outwardly from a portion of the distal end of the drainage lumen portion, the retention portion including a proximal end having a first diameter, a distal end having a second diameter, and a wall and/or surface extending therebetween, the retention portion having a second diameter is greater than the first diameter when deployed; or wherein the retention portion includes a plurality of drainage tubes. 13 132 21 130 121212 1181F 118 1210 124 140t ...

Methods of regional citrate anticoagulation dialysis

A method of performing regional citrate anticoagulant dialysis of a patient's blood includes flowing blood from and back to the patient through an extracorporeal circuit including a dialyzer having semi-pelmeable dialysis membranes and a dialysate chamber surrounding the membranes. The method further includes flowing a dialysate containing calcium and citrate through the dialysate chamber of the dialyzer and introducing citrate into the patient's blood upstream of the dialyzer, whereby the patient's blood is dialyzed. The method can further include predicting the concentration of systemic ionized calcium in the blood of the patient at any point in the dialysis treatment or post-dialysis, such as by a mathematical model. The method can further include statistically correcting the preliminary predicted postdialysis concentration of systemic ionized calcium in the patient's blood to provide a final predicted post-dialysis systemic ionized calcium concentration.

NMR methods for monitoring blood clot formation

The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.

Transdermal drug delivery patch system, method of making same and method of using same

Ureteral and bladder catheters and methods for inducing negative pressure to increase renal perfusion

Ureteral catheters and assemblies provided including: a drainage lumen including a proximal portion configured to be positioned in at least a portion of a patient's urethra and a distal portion configured to be positioned in a patient's ureter and/or kidney, the distal portion including a coiled retention portion including at least a first coil having a first diameter and a second coil having a second diameter, the first diameter being less than the second diameter; or wherein the retention portion extends radially outwardly from a portion of the distal end of the drainage lumen portion, the retention portion including a proximal end having a first diameter, a distal end having a second diameter, and a wall and/or surface extending there between, the retention portion having a second diameter is greater than the first diameter when deployed; or wherein the retention portion includes a plurality of drainage tubes.

SYSTEMS AND METHODS FOR SHUNTING FLUID

METHODS AND APPARATUS FOR EXTRACTING AND ANALYZING A BODILY FLUID

IMPLANTABLE FLUID EXTRACTION SYSTEM

A fluid extraction implantable system shaped and sized to be implanted in a patient, including: a fluid extraction chamber having a flat and thin shape connected to a draining tube and including at least one external flat surface, wherein the at least one external flat surface is configured to be attached to a tissue surface when a negative pressure is applied on the draining tube, wherein the chamber extracts fluids from the tissue by applying the negative pressure through the flat surface on the attached tissue surface.

METHOD AND APPARATUS FOR DETECTION OF MULTIPLE ANALYTES

An apparatus (10) for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end (11) configured to maintain fluid communication with a bodily fluid in a patient and at least one pump (203) intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer (140) positioned to analyze at least a portion of the sample and measure the presence of two or more analytes . Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample. Disclosed are further means for separating plasma and serum and a spectroscopic analyzer ...

IMPLANTABLE SENSOR METHOD AND SYSTEM

Systems and methods for non-vascular sensor implantation and for measuring physiological parameters in areas of a body where the physiological parameters are heterogeneous. An implant unit is implanted in an area of a body and a foreign body capsule is allowed to form around the implant unit area. A sensor may be directed into a body cavity such as, for example, the peritoneal space, subcutaneous tissues, the foreign body capsule, or other area. A subcutaneous area of the body may be tunneled for sensor placement. Spatially separated sensing elements may be used for detecting individual amounts of the physiological parameter. An overall amount of the physiological parameter may be determined by calculating a statistical measurement of the individual sensed amounts in the area. Another embodiment of the invention, a multi- analyte measuring device, may include a substrate having an electrode array on one side and an integrated circuit on another side.

CARDIAC ASSIST DEVICE

A cardiac pump and an assist system is provided that increases blood ejection from a compromised heart. An implantable cardiac pump acting as an assist device provided includes an attachment system and locating features that enable a minimally invasive procedure to implant and deploy one or more aortic blood pumps in a patient. The insertable cardiac pump is replaceable without resort to a conventional open surgical procedure. Monitoring of cardiac pump operation allows for replacement in advance of chamber failure. The dynamics of blood- contacting interface of the cardiac assist device mimic the dynamics of the blood-contacting interface of a naturally occurring left ventricle, thereby minimizing flow-related device- associated pathologic disturbances of intravascular clotting mechanisms. A process of operating a cardiac assist device includes cyclically inflating and deflating one or more inflatable cardiac pumping chambers with timing and parameters as to pressure, deflection, and speed ...

METHOD AND APPARATUS FOR DETECTION OF MULTIPLE ANALYTES

An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and at least one pump intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer positioned to analyze at least a portion of the sample and measure the presence of two or more analytes. Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample. Disclosed are further means for separating plasma and serum and a spectroscopic analyzer.

SYSTEMS AND METHODS FOR SHUNTING FLUID

Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRl)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRl, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system and for opening auxiliary fluid pathways through a shunt system are also disclosed herein ...

DEVICES, SYSTEMS AND METHODS FOR LOCATING AND INTERACTING WITH MEDICAMENT DELIVERY SYSTEMS

In some embodiments, a method includes establishing a communications link between a computing device and an adapter. The adapter is configured to receive at least a portion of a medicament delivery device. A wireless signal is received to maintain the communications link. A relative position between the computing device and the adapter is determined. An alarm is produced when the wireless signal is not received within a time period. The alarm is based on the relative position between the computing device and the adapter ...

FEEDBACK CONTROLLED DRUG DELIVERY SYSTEM

A feedback controlled drug delivery system includes automated blood sampling and analysis and dosing of the patient. Automated sampling is performed by direct analysis of patient blood, such as for measurement of its coagulation state. A novel manifold includes a fluid input port, a patient port adapted to output fluid and to receive a blood sample from the patient, and a fluid pathway connecting the fluid port and the patient port. A sample line is connected to the fluid pathway to provide the sample to an analyzer. In one aspect of this invention, the sample is forced through the sample line by isolating the patient port, such as by a valve, and non-drug fluid is forced into the manifold causing the blood to cross through the sample line. In another embodiment, an integrated assembly includes an integrated peristaltic pump, valve assembly, selectively movable actuator and integrated waste container. In one aspect, the peristaltic pump permits retraction of the rollers away from the inner ...

Einrichtung zum Anästhesieren von Lebewesen mit elektrischen Strömen

ASPIRATORY

Medical system, method and apparatus employing mems

SELF CALIBRATING BLOOD CHAMBER

IMPLANTABLE INFUSION DEVICE WITH NEEDLE THAT CAN ADVANCE AND RETRACT

sistema para tratamento personalizado imediato de um paciente em uma emergência médica

DEVICE FOR DETERMINING THE CONCENTRATION OF A BLOOD CONSTITUENT IN A TUBE LINE

The invention relates to a device for determining the concentration of a blood constituent in a tube line, in particular in the tube line of an extracorporeal blood circuit of an extracorporeal blood treating device. The invention further relates to a method for detecting a tube line, in particular a tube line of an extracorporeal blood circuit of an extracorporeal blood treating device, in a clamping unit of a device for determining the concentration of a blood constituent in the tube line. The device according to the invention for determining the concentration of a blood constituent in a tube line of an extracorporeal blood circuit is characterized by a clamping unit (12) that has an actuating mechanism (18) which is designed such that a first and second receiving element (15, 16) can be moved relative to each other from a first position that releases the tube line into a second position that clamps the tube line by applying a clamping force, said actuating mechanism being driven by an ...

MEASUREMENT DEVICE, DEVICE FOR DETERMINING DIALYSIS COMPLETION CONDITION, AND DEVICE FOR DISPLAYING PROGRESS OF DIALYSIS

The measurement device (10): is provided with an analysis unit (101) that holds a liquid pool (B) of blood or serum, an irradiation unit (105) that irradiates excitation light on a fluorescent substance contained in the liquid pool (B), and a light-receiving unit (106) that receives fluorescent light from the fluorescent substance; and estimates, from the fluorescence intensity, the amount of the fluorescent substance contained in the blood or serum after artificial dialysis.

METHOD AND APPARATUS FOR THE ADMINISTRATION OF CO

The present invention relates to a method and apparatus for the administration of carbon monoxide (CO) to a patient. It allows the safe and effective use of carbon monoxide as a medicament.

METHOD AND APPARATUS FOR DETECTION OF A BUBBLE IN A LIQUID

Dans le cadre de ce procédé, on introduit un liquide dans une enceinte de mesure, lequel liquide est en contact avec un capteur permettant de mesurer la concentration d'un gaz particulier dans ledit liquide. Il est procédé à une première mesure de la concentration en gaz sous une première pression régnant dans l'enceinte de mesure, à la suite de quoi, on fait varier la pression régnant dans l'enceinte de mesure. Il est alors procédé à une seconde mesure de la concentration en gaz sous une seconde pression régnant dans l'enceinte de mesure. On obtient un résultat escompté de la seconde mesure, lequel résultat repose sur la première mesure, dans l'hypothèse où il n'y a pas de bulles dans l'enceinte de mesure lors de l'une ou de l'autre des mesures. On compare le résultat réel issu de la seconde mesure au résultat escompté.

Apparatus and methods for delivery of therapeutic agents to mucous or serous membrane

A method, apparatus, and system are provided for mucous membrane therapy. The method includes receiving at least one body signal from a patient; detecting a condition of the patient based on the body signal; and administering the therapy to at least one of a mucous membrane or a serous membrane of the patient. A medical device system configured to implement the method is provided. A computer-readable storage device for storing instructions that, when executed by a processor, perform the method is also provided.

IMPLANTABLE FLUID EXTRACTION SYSTEM

A fluid extraction implantable system shaped and sized to be implanted in a patient, including: a fluid extraction chamber having a flat and thin shape connected to a draining tube and including at least one external flat surface, wherein the at least one external flat surface is configured to be attached to a tissue surface when a negative pressure is applied on the draining tube, wherein the chamber extracts fluids from the tissue by applying the negative pressure through the flat surface on the attached tissue surface.

SYSTEM FOR MONITORING DOSE PATTERN AND PATIENT RESPONSE

A method for tracking dose pattern and patient response may include determining, based at least on one or more dose events at a pump configured to deliver a medication to a patient, a dose pattern for delivering the medication to the patient. One or more vital signs associated with the patient may be received from a patient monitor. A presence of one or more anomalies may be determined based at least on the dose pattern at the pump and the one or more vital signs of the patient. An electronic alert may be sent to a mobile device in response to determining the presence of the one or more anomalies. Related methods and articles of manufacture, including apparatuses and computer program products, are also disclosed.

BREATHING DEVICES AND RELATED SYSTEMS AND METHODS

Breathing devices deliver at least one treatment to a subject and include at least two components comprising at least one of a ventilation unit for supplying a gas to the subject, a humidification unit for humidifying a gas supplied to the subject, a nebulizer unit for supplying a medication to the subject, a suction unit for suctioning a portion of an airway of the subject, and a cough assist unit for simulating a cough within the subject. Methods of providing a treatment to a subject may be provided with a breathing device.

METHOD SYSTEM AND DEVICE FOR ASSESSING INSULIN SENSITIVITY

A method and a system for determining insulin sensitivity (IS) is described. In one aspect the method and the system can be implemented by receiving a first parameter corresponding to an insulin dose in a subcutaneous tissue; applying a first kinetic model to obtain a plasma insulin concentration based on the first parameter; receiving a second parameter corresponding to a plasma glucose concentration; determining the insulin sensitivity (IS) based on the plasma insulin concentration and the second parameter.

Drug device configured for wireless communication

This invention relates to an ingestible drug delivery device configured for wireless communication with other ingestible drug delivery devices.

УСТРОЙСТВО ДЛЯ ЛЕЧЕНИЯ ИНДИВИДУУМА СО СНИЖЕННОЙ ФУНКЦИЕЙ СЕРДЦА, ОСТАНОВКОЙ СЕРДЦА, ОСТАНОВКОЙ КРОВООБРАЩЕНИЯ ИЛИ АПОПЛЕКСИЧЕСКИМ УДАРОМ

Группа изобретений относится к медицине. Устройство содержит применяемое на индивидууме средство взятия крови, блок анализа, связанный со средством для взятия крови, для определения и предоставления характеристик крови в виде результата анализа крови, исполнительный блок, связанный с применяемым на индивидууме средством обратной подачи и выполненный с возможностью передачи вещества индивидууму через средство обратной подачи. При этом исполнительный блок содержит блок резервуара, который создает запас веществ. С блоком резервуара предусмотрен блок дозирования, который с учетом результатов анализа крови выбирает вещества или изготавливает смесь веществ. Устройство также содержит блок оценки и контроля, выполненный с возможностью осуществления обмена информацией с блоком анализа и блоком дозирования и генерации управляющих сигналов для управления блоком дозирования. При осуществлении способа у индивидуума берут кровь, которую подвергают анализу. Затем с учетом результата анализа крови и критериев ...

СПОСОБ ОПРЕДЕЛЕНИЯ КОЭФФИЦИЕНТА СНИЖЕНИЯ ИЛИ ЗНАЧЕНИЯ Kt/V ПРИ ПРОВЕДЕНИИ ЗАМЕСТИТЕЛЬНОЙ ПОЧЕЧНОЙ ТЕРАПИИ И УСТРОЙСТВО ДЛЯ РЕАЛИЗАЦИИ ЭТОГО СПОСОБА

Группа изобретений относится к медицине и используется для мониторинга эффективности заместительной почечной терапии. Мониторинг осуществляется на основании значений коэффициента снижения RR или показателя Kt/V. Выполняют измерение концентрации по меньшей мере одного продукта жизнедеятельности с использованием спектрофотометрии в используемой для заместительной терапии отводимой жидкости. Отводимая жидкость циркулирует по замкнутому контуру относительно поступающей через устройство по замещению функции почек крови до тех пор, пока спектрофотометрический показатель отводимой жидкости не достигнет постоянной величины Аво. Коэффициент RR или показатель Kt/V определяют по уравнениям RR=1-Ав(t)/Аво или Kt/V=-ln(Ав(t)/Аво), где Aв(t) - спектрофотометрический показатель используемой для заместительной почечной терапии отводимой жидкости в момент времени t проведения начатой после рециркуляции отводимой жидкости процедуры заместительной терапии, K - эффективный клиренс продукта жизнедеятельности ...

МОЧЕТОЧНИКОВЫЙ КАТЕТЕР И МОЧЕПУЗЫРНЫЙ КАТЕТЕР И СПОСОБЫ СОЗДАНИЯ ОТРИЦАТЕЛЬНОГО ДАВЛЕНИЯ ДЛЯ УВЕЛИЧЕНИЯ ПОЧЕЧНОЙ ПЕРФУЗИИ

Device for real-time measurement of electrolytes, especially sodium ion concentration, in blood of patient undergoing operation comprises sensor for blood component connected to processor for signals produced

Device for real-time measurement of electrolytes in the blood of a patient undergoing an operation comprises a sensor (7) for a blood component which is connected to a processor (8) for the signals produced by the sensor. An Independent claim is included for a device for introducing a liquid (1) into a body cavity (2) comprising a catheter (4) with a control device (5) operated by a processor connected to a measuring device as described above.

Vorrichtung zur Bestimmung der Konzentration eines Bestandteils von Blut in einer Schlauchleitung und Verfahren zur Erkennung einer Schlauchleitung in einer Einspanneinheit

Die Erfindung betrifft eine Vorrichtung zur Bestimmung der Konzentration eines Bestandteils von Blut in einer Schlauchleitung, insbesondere in der Schlauchleitung eines extrakorporalen Blutkreislaufs einer extrakorporalen Blutbehandlungsvorrichtung. Darüber hinaus betrifft die Erfindung ein Verfahren zur Erkennung einer Schlauchleitung, insbesondere einer Schlauchleitung eines extrakorporalen Blutkreislaufs einer extrakorporalen Blutbehandlungsvorrichtung, in einer Einspanneinheit einer Vorrichtung zur Bestimmung der Konzentration eines Blutbestandteils in der Schlauchleitung. Die erfindungsgemäße Vorrichtung zur Bestimmung der Konzentration eines Bestandteils von Blut in einer Schlauchleitung eines extrakorporalen Blutkreislaufs zeichnet sich durch eine Einspanneinheit 12 aus, die einen Betätigungsmechanismus 18 aufweist, der derart ausgebildet ist, dass unter Aufbringung einer Spannkraft ein erstes und zweites Aufnahmeelement 15, 16 aus einer ersten die Schlauchleitung freigebenden Stellung ...

System zur Erfassung eines Zustands einer Dialysatorvorrichtung, und hierfür verwendbare Sensorvorrichtung

Ein System zum Erfassen oder Messen von Informationen bezüglich eines Zustands, z.B. einer Dialysance, bzw. zur Identifizierung einer Dialysatorvorrichtung (100) oder einer Membranfiltereinrichtung (190) der Dialysatorvorrichtung (100) während des Betriebs der Dialysatorvorrichtung (100) in einer Dialysebehandlung eines Patienten (10), umfassend: eine Dialysatorvorrichtung (100) mit einem einen Innenvolumenbereich (120) umschließenden Gehäuse (110) und einer im Wesentlichen in dem Innenvolumenbereich (120) angeordneten Membranfiltereinrichtung (190), wobei das Gehäuse (110) für ein Signal, wie etwa ein Strahlungssignal, zumindest bereichsweise durchlässig ist, und eine Sensorvorrichtung (200), die mit dem Gehäuse (110) der Dialysatorvorrichtung (100) lösbar operativ verbindbar ist und die eine Signalempfangseinrichtung (210, 212, 220, 222, 224) umfasst, die dazu ausgebildet ist, mindestens ein Signal, wie etwa ein Strahlungssignal, von dem Gehäuse oder aus dem Innenvolumenbereich (120) ...

Überwachungssystem für herzchirurgische Operationen mit kardiopulmonalem Bypass

Mechanism to treating or Anaesthesieren of an organism with electric currents

Implantable infusion device with advanceable and retractable needle

TRANSDERMAL DRUG DELIVERY PATCH SYSTEM, METHOD OF MAKING SAME AND METHOD OF USING SAME

Positive airway pressure system with integrated oxygen

A device and a system that delivers continuous positive airway pressure in conjunction with oxygen delivery is disclosed. The system is portable so that patients may be mobile and conveniently travel. Several means are disclosed for integrating oxygen production into a positive airway pressure (PAP) device, including oxygen production machinery entirely integrated into the PAP housing, oxygen production machinery that mates with a PAP device but which may operate independently, and where portions of the oxygen production machinery are located in the PAP housing and other portions (for example, the compressor) are located in a separate module, such as, for example, an AC-to-DC power conversion module.

Combination pressure therapy for treatment of serum lipid levels, steroid levels, and steroidogenesis

Methods of regional citrate anticoagulation dialysis

A method of performing regional citrate anticoagulant dialysis of a patient's blood includes flowing blood from and back to the patient through an extracorporeal circuit including a dialyzer having semi-pelmeable dialysis membranes and a dialysate chamber surrounding the membranes. The method further includes flowing a dialysate containing calcium and citrate through the dialysate chamber of the dialyzer and introducing citrate into the patient's blood upstream of the dialyzer, whereby the patient's blood is dialyzed. The method can further include predicting the concentration of systemic ionized calcium in the blood of the patient at any point in the dialysis treatment or post-dialysis, such as by a mathematical model. The method can further include statistically correcting the preliminary predicted postdialysis concentration of systemic ionized calcium in the patient's blood to provide a final predicted post-dialysis systemic ionized calcium concentration.

System for analyzing vascular refill during short-pulse ultrafiltration in hemodialysis

A method includes: receiving measurements of a blood-related parameter corresponding to a patient undergoing hemodialysis; estimating a value of one or more hemodialysis treatment related parameters by applying a vascular refill model based on the received measurements of the blood-related parameter, wherein the one or more hemodialysis treatment-related parameters are indicative of an effect of vascular refill on the patient caused by the hemodialysis; determining, based on the one or more estimated values of the one or more hemodialysis treatment-related parameters, a hemodialysis treatment-related operation; and facilitating performance of the treatment-related operation. The vascular refill model is a two-compartment model based on a first compartment corresponding to blood plasma in the patient's body, a second compartment based on interstitial fluid in the patient's body, and a semi-permeable membrane separating the first compartment and the second compartment.

METHODS AND APPARATUS FOR EXTRACTING AND ANALYZING A BODILY FLUID

A method of extracting and analyzing bodily fluids from a patient at the point of care for the patient is provided. The method comprises establishing fluid communication between an analyte detection system 334, 1700 and a bodily fluid in the patient. A portion of the bodily fluid is drawn from the patient. The drawn portion is separated into a first component of the bodily fluid, while the analyte detection system 334, 1700 remains in fluid communication with the patient. The analyte detection system 334, 1700 analyzes the first component to measure a concentration of an analyte.

METHOD AND APPARATUS FOR THE ADMINISTRATION OF CO

The present invention relates to a method and apparatus for the administration of carbon monoxide (CO) to a patient. It allows the safe and effective use of carbon monoxide as a medicament.

SLEEP GUIDANCE SYSTEM AND RELATED METHODS

A sleep efficiency monitor and methods for pacing and leading a sleeper through an optimal sleep pattern. Embodiments of the present invention include a physiological characteristic monitor (14) for monitoring the sleep stages of a sleeper, a sensory stimulus generator (16) for generating stimulus to affect the sleep stages of a sleeper, and a processor (12) for determining what sleep stage the sleeper is in and what sensory stimulus is needed to cause the sleeper to move to another sleep stage. A personalized sleep profile may also be established for the sleeper and sleep guided in accordance with the profile parameters to optimize a sleep session.

METHOD FOR DELIVERY OF BREATHING GAS TO A PATIENT AND SYSTEM FOR PERFORMING SAME

A method for controlling the delivery of a breathing gas to a patient. The method comprises: delivering a flow of breathing gas to a patient, the breathing gas having a breathing gas flowrate and a fraction of inspired oxygen; measuring an oxygen saturation level of the patient; determining a respiratory rate of the patient; automatically adjusting the fraction of inspired oxygen of the breathing gas based on the measured oxygen saturation level of the patient and a breathing gas flowrate set-point; and automatically adjusting the breathing gas flowrate set-point based on the determined respiratory rate of the patient.

SYSTEMS, CATHETERS, AND METHODS FOR TREATING ALONG THE CENTRAL NERVOUS SYSTEM

Systems, catheters, and methods for accessing and treating along the central nervous system are disclosed. An example method may manage inflammation of the patient to treat a condition of the patient by processing values related to one or more physiological parameters of a patent, identifying when an inflammation condition of the patient has reached a treatment condition based on the processed values, and automatically providing an indication that the inflammation condition has reached the treatment condition. An example indication may include actuation of a treatment protocol. The example method may be performed with an inflammation management system.

A METHOD FOR ASSESSING A PATIENT'S FLUID STATUS AND/OR SENSITIVITY TO FLUID REMOVAL, CONTROLLER, AND DEVICES

The present invention relates to a method for assessing a patient's sensitivity to fluid removal from his vascular system or to fluid replacement or addition regarding to his hydration state, the method comprising the step of determining a value reflecting the distribution of fluid between at least two distribution spaces of the body of the patient or changes thereof from measured or calculated values, and assessing whether the value fulfils at least one criterion. It also relates to a controller, an apparatus, a device, a digital storage means, a computer program product, and a computer program.

MONITORING DEVICE FOR MANGEMENT OF INSULIN DELIVERY

A monitoring system and method is presented for use with diabetic treatment management. The monitoring system comprises a control unit, and a communication interface, which configured and operable to permit access to stored raw log data, which have been obtained over a certain time and being time spaced data points of glucose measurements, meals consumed and insulin delivery. The control unit comprises an unsupervised learning controller configured and operable to receive and process said raw log data, to determine an informative data piece from residual log data portion of said raw log data and select said informative data piece for retrospective analysis to calculate at least one global insulin pump setting of basal rate, correction factor (CF), carbohydrate ratio (CR) and insulin activity curve parameters.

METHODS OF REGIONAL CITRATE ANTICOAGULATION DIALYSIS

A method of performing regional citrate anticoagulant dialysis of a patient's blood includes flowing blood from and back to the patient through an extracorporeal circuit including a dialyzer having semi-pelmeable dialysis membranes and a dialysate chamber surrounding the membranes. The method further includes flowing a dialysate containing calcium and citrate through the dialysate chamber of the dialyzer and introducing citrate into the patient's blood upstream of the dialyzer, whereby the patient's blood is dialyzed. The method can further include predicting the concentration of systemic ionized calcium in the blood of the patient at any point in the dialysis treatment or post-dialysis, such as by a mathematical model. The method can further include statistically correcting the preliminary predicted postdialysis concentration of systemic ionized calcium in the patient's blood to provide a final predicted post-dialysis systemic ionized calcium concentration.

ANTI-CLOTTING APPARATUS AND METHODS FOR FLUID HANDLING SYSTEM

A method for maintaining clear passageways in an extracorporeal blood flow system. The method comprises intermittently providing one or more anti-clotting agents to a passageway of the extracorporeal blood flow system. Also disclosed is an extracorporeal blood flow system. The system comprises a passageway, and a device operatively connected to provide one or more anti-clotting agents to a least a portion of said passageway. The anti-clotting agents can be ultrasound or detergent ...

SKIN INTERFACE DEVICE FOR CARDIAC ASSIST DEVICE

A skin interface device ("SID") for a cardiac assist device, including a SID cap having a first housing, an annular sleeve, and a first annular winding disposed over said annular sleeve. The SID further includes a SID base having a second housing formed to include a tubular portion, a cylindrical member disposed in said tubular portion, and a second annular winding disposed around said cylindrical member. The SID cap is configured to be rotationally attached to said SID base. When the SID cap is attached to the SID base, the second annular winding is disposed within the first annular winding, and the relative positions of the first annular winding and the second annular winding are fixed both laterally and vertically.

AN APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT.

It is disclosed an apparatus for extracorporeal blood treatment (1) having a control unit (15) connected to an ultrafiltration device (20) and to a fluid preparation section (30) of fresh dialysis liquid. The control unit (15) is configured to receive measured values of the change of blood volume, the amount of ultrafiltration volume, and conductivity or to the concentration for at least one substance in the blood (BV%mes(t); UFmes(t), WLmes(t); Cbmes(t)); the control unit (15) is also configured to receive prescription values for the same parameters and to control ultrafiltration and adjust conductivity in the fresh dialysis liquid based on the difference between said measured values and said prescription values.

SELF CALIBRATING BLOOD CHAMBER

An optical blood monitoring system and corresponding method avoid the need to obtain a precise intensity value of the light impinging upon the measured blood layer during the analysis. The system is operated to determine at least two optical measurements through blood layers of different thickness but otherwise substantially identical systems. Due to the equivalence of the systems, the two measurements can be compared so that the bulk extinction coefficient of the blood can be calculated based only on the known blood layer thicknesses and the two measurements. Reliable measurements of various blood parameters can thereby be determined without certain calibration steps.

METHOD FOR EVALUATING LIQUID STNOGO STATUS OF A PATIENT AND/OR SENSITIVITY TO REMOVAL OF LIQUID STI, CONTROLLER AND DEVICE

Computer controlled dosage system

DEVICE FOR ADJUSTING AN AMOUNT OF NICOTINE INHALED BY A USER AND COMMUNICATING PORTABLE TERMINAL

A METHOD FOR ASSESSING A PATIENT'S FLUID STATUS AND/OR SENSITIVITY TO FLUID REMOVAL, CONTROLLER, AND DEVICES

Method for determining concentration; a dialyser

The present invention relates to a method for determining the concentration of an ion, atom or molecule bound in a complex. A reliable determination of the concentration of the ion, atom or molecule to be determined is possible in accordance with the invention in that the complexing of the ion, atom or molecule is prevented at least during the determination of the concentration by the addition or withdrawal of a substance. The present intervention further relates to a dialyser having a haemo-dialyser and/or a haemo-filter and having an extra-corporal blood circulation with which means for the adding of citrate to the blood are connected upstream of the haemo-dialyser and/or of the haemo-filter and means for the adding of a substitution solution containing ions to the blood are connected downstream of the haemo-dialyser and/or of the haemo-filter, and having a dialysate line which has means for the detection of an ion concentration in the dialysate downstream of the haemo-dialyser and/or ...

Pneumatic or hydraulic cardiac assist devices

The embodiments relate to cardiac assist devices that comprise a jacket that wraps the exterior of the heart, where the jacket comprises one or more pneumatic or hydraulic bladders. The pneumatic or hydraulic bladders are linked to a pump, and the pump fills the bladders with fluid and withdraws the fluid in a cycle to match beats of the heart to assist contraction and pumping of the heart in systole or to assist expansion and filling of the heart in diastole.

Drug device configured for wireless communication

This invention relates to an ingestible drug delivery device configured for wireless communication with other ingestible drug delivery devices.

Anti-Clotting Apparatus and Methods for Fluid Handling System

A method for maintaining clear passageways in an extracorporeal blood flow system. The method comprises intermittently providing one or more anti-clotting agents to a passageway of the extracorporeal blood flow system. Also disclosed is an extracorporeal blood flow system. The system comprises a passageway, and a device operatively connected to provide one or more anti-clotting agents to a least a portion of said passageway.

HEMOGLOBIN DISPLAY AND PATIENT TREATMENT

The present disclosure describes embodiments of a patient monitoring system and methods that include the measure and display of hemoglobin statistics. In an embodiment, total hemoglobin trending is displayed over a period of time. Statistics can include frequency domain analysis, which may be unique for each patient monitored. The total hemoglobin trending and/or statistics can further be used to help control the treatment of a patient, such as being used to control IV administration.

Detecting, assessing and managing a risk of death in epilepsy

A method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy is provided. The method includes receiving cardiac data and determining a cardiac index based upon the cardiac data. The method includes determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. Also presented is a second method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy comprising receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively. The second method includes determining an increased risk of death related to epilepsy if indices are extreme values, issuing a warning ...

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT II

An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysis fluid circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for determining or receiving a proposed value (prop.value; Cprop.value) of a sodium concentration for the dialysis fluid in the dialysis supply line (8) and to determine a set value (fsetvalue; Cse tvalue) for the sodium concentration in the dialysis fluid as a function of the proposed value (prop.value; Cprop.value). For at least an interval of proposed values for the sodium concentration, the control unit (12) is configured to determine the set value so that the set value is different from the proposed value (prop.value; cprop.value) and so that distinct set values are determined from distinct proposed values. The set value is biased towards a predetermined pivot value that represents e.g. the average ...

METHOD AND SYSTEM FOR AUTOMATING OXYGEN MONITORING AND DOSING IN REAL TIME FOR PATIENT ON OXYGEN THERAPY

This system and method for automating oxygen monitoring and dosing in real time for a patient on oxygen therapy is disclosed. The system includes a flow regulator coupled to an oxygen source for operably controlling a flow rate of oxygen from the oxygen source to the patient; a wearable device configured to be worn by the patient for measuring physiological parameters of the patient to monitor a physiological status of the patient; and a controller in wireless communication with the wearable device and the flow regulator for receiving the measured physiological parameters from the wearable device, and controlling operations of the flow regulator to regulate the flow rate of oxygen from the oxygen source for providing a desired amount of oxygen to the patient based on the physiological status of the patient.

APPARATUS FOR EXTRACTING AND ANALYZING A BODILY FLUID

RESPIRATORY THERAPY FILTER DETECTION SYSTEM AND METHOD

УСТРОЙСТВО УПРАВЛЕНИЯ СНОМ И СПОСОБЫ УПРАВЛЕНИЯ СНОМ

Изобретение относится к области медицины. Способы управления типом сна спящего заключаются в осуществлении мониторинга физиологических характеристик спящего, указывающих на текущую стадию сна спящего, генерировании сенсорного стимула для навязывания спящему ритма сна и изменении сенсорного стимула для перевода спящего в стадию сна, отличную от текущей стадии сна. Устройства для настройки типа сна содержит монитор физиологической характеристики, генератор сенсорного стимула, процессор, функционально связанный с монитором физиологической характеристики и генератором сенсорного стимула. Процессор предназначен для приема входящего сигнала от монитора физиологической характеристики и обеспечения выходного сигнала для генератора сенсорного стимула. Применение данной группы изобретений позволяет достигнуть эффективного сна и более продуктивного использования времени сна. 5 н. и 79 з.п. ф-лы, 4 ил.

УПРАВЛЯЮЩЕЕ УСТРОЙСТВО ДЛЯ УПРАВЛЕНИЯ ВВЕДЕНИЕМ ПРОПОФОЛА ДЛЯ ПАЦИЕНТА

Изобретение относится к медицине, а именно к управляющему устройству для управления введением пропофола для пациента. Предложены управляющее устройство для реализации способа, устройство содержит интерфейс человек-машина, насос инфузии, который содержит контроллер для вычисления рекомендуемой скорости инфузии для введения пропофола пациенту, монитор глубины анестезии. Предусмотрены также: блок целевой установки для установки целевой величины биспектрального показателя (BIS), модельный блок для определения чувствительности пациента к пропофолу с помощью PK/PD модели учитывающей (BIS). Причем оценка чувствительности пациента к анестетику основана на PK/PD модели, которая содержит 3+1 PK/PD модель, отделение Х удаления и отделение S датчика BIS. Причем 3+1 PK/PD модель основана на центральном отделении А, содержащем концентрацию Ср пропофола в крови, отделение CRD быстрого равновесия, отделение CSD медленного равновесия, отделение Е действия, содержащее концентрацию Се отделения действия пропофола ...

УСТРОЙСТВО ДЛЯ ВЗАИМОДЕЙСТВИЯ С КОЖЕЙ ДЛЯ УСТРОЙСТВА СТИМУЛЯЦИИ СЕРДЕЧНОЙ ДЕЯТЕЛЬНОСТИ

СПОСОБ ОПРЕДЕЛЕНИЯ КОЭФФИЦИЕНТА СНИЖЕНИЯ ИЛИ ЗНАЧЕНИЯ Kt/V ПРИ ПРОВЕДЕНИИ ЗАМЕСТИТЕЛЬНОЙ ПОЧЕЧНОЙ ТЕРАПИИ И УСТРОЙСТВО ДЛЯ РЕАЛИЗАЦИИ ЭТОГО СПОСОБА

... 1. Способ определения коэффициента снижения или значения Kt/V при проведении заместительной почечной терапии, в котором осуществляется измерение концентрации, по меньшей мере, одного продукта жизнедеятельности с использованием спектрофотометрии непосредственно в отводимой жидкости, используемой для заместительной почечной терапии, характеризующийся тем, что ! отводимая жидкость, используемая для заместительной почечной терапии, циркулирует по замкнутому контуру относительно крови, поступающей через устройство по замещению функции почек, до тех пор, пока спектрофотометрический показатель отводимой жидкости, используемой для заместительной почечной терапии, не достигнет (практически) постоянной величины ABO, а также ! коэффициент снижения (RR), по меньшей мере, одного продукта жизнедеятельности определяется по уравнению ! RR=1-AB(t)/ABO, ! или показатель Kt/V определяется по уравнению ! Kt/V=-ln(AB(t)/ABO), ! где AB(t) - спектрофотометрический показатель отводимой жидкости, используемой для ...

Armbanduhr mit Meßfunktion

Armbanduhr, umfassend ein Gehäuse (10), eine Zeitmeßvorrichtung (32), eine Probenmeßvorrichtung (34) zum ampereometrischen Vermessen eines Teststreifens (24), der mindestens ein mit einer zu untersuchenden Flüssigkeit benetzbares Testfeld hat und eine mit der Zeitmeßvorrichtung (32) und der Probenmeßvorrichtung (34) verbundene Anzeigevorrichtung (14), dadurch gekennzeichnet, daß an dem Gehäuse (10gsteil (38) angeordnet ist, das parallel zu einer Gehäuseaußenfläche (28) gerichtet ist und zusammen mit dieser einen Aufnahmeschacht (40) zum Halten eines Teststreifens (24) in einer vorgegebenen Position begrenzt, und daß in der genannten Gehäuseaußenfläche (28) mindestens zwei mit der Probenmeßvorrichtung (34) verbundene und zum Kontaktieren von Elektroden (52) des Teststreifens (24) bestimmte Meßkontaktelemente (50) so angeordnet sind, daß ihre freien Enden in den Aufnahmeschacht (40) ragen.

Aspirators

A valve assembly 50 comprising a three-way connector 51 operatively interconnecting: an inlet 58, an outlet 56 and a vent 66, the inlet 58 being operatively connectable, in use, to an aspirator tube; the outlet 56 being operatively connectable, in use, to a syringe 82; and the vent 66 comprising a one-way valve 70 permitting, in use, the flow of a fluid out of the three-way connector 51, wherein the inlet 58 comprises a receptacle 60 containing a porous or perforated element 62 which, when dry, permits the flow of gasses into the three-way connector 51, but which when wetted by a liquid, inhibits or prevents the flow of liquid into the three-way connector 51.

PROCEDURE AND DEVICE FOR THE PROOF OF A GAS BUBBLE IN A LIQUID

PROCEDURE FOR THE PROOF OF SEVERAL ANALYTEN

SENSOR UNIT AND PROCEDURE FOR THE MEASUREMENT OF A BLOOD-RELEVANT PARAMETER AND SYSTEM WITH SUCH A SENSOR UNIT

Patient-controlled analgesia with patient monitoring system

Implantable infusion device with advanceable and retractable needle

An infusion device for a drug delivery system comprises an infusion needle (1) having a tip end (2) and a drive unit (D) coupled to the infusion needle and arranged for advancing the tip end of the infusion needle to penetrate any fibrosis when the infusion device is implanted in a patient's body. The infusion needle and drive unit are designed for implantation in a patient's body. Other components of the drug delivery system may be part of the implantable infusion device or, alternatively, be for extracorporal use cooperating with the implanted infusion device. Preferably, the infusion needle can be advanced and retracted with each infusion cycle. Furthermore, upon each advancement and/or retraction, the needle may be moved laterally so as to vary the injection site. Needle (1 ) and drive unit (D) are preferably disposed within a body (15), with the infusion needle being arranged for penetrating a self-sealing penetration membrane (18).

Implantable sensor method and system

NMR methods for monitoring blood clot formation

The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.

Breathing devices and related systems and methods

Breathing devices deliver at least one treatment to a subject and include at least two components comprising at least one of a ventilation unit for supplying a gas to the subject, a humidification unit for humidifying a gas supplied to the subject, a nebulizer unit for supplying a medication to the subject, a suction unit for suctioning a portion of an airway of the subject, and a cough assist unit for simulating a cough within the subject. Methods of providing a treatment to a subject may be provided with a breathing device.

Self calibrating blood chamber

An optical blood monitoring system and corresponding method avoid the need to obtain a precise intensity value of the light impinging upon the measured blood layer during the analysis. The system is operated to determine at least two optical measurements through blood layers of different thickness but otherwise substantially identical systems. Due to the equivalence of the systems, the two measurements can be compared so that the bulk extinction coefficient of the blood can be calculated based only on the known blood layer thicknesses and the two measurements. Reliable measurements of various blood parameters can thereby be determined without certain calibration steps.

Determination of gases dissolved in blood in the extracorporeal blood flow

The invention relates to a blood treatment device having an extracorporeal blood flow, which measures the concentration of a gas in the gas supernatant of the drip chamber of the extracorporeal blood flow by means of a gas sensor. The blood treatment device comprises an analysis unit which calculates the partial pressure of the gas in the blood from the values measured in the gas supernatant of the drip chamber.

Devices and methods for respiratory variation monitoring by measurement of respiratory volumes, motion and variability

This invention is directed to devices and methods for assessing a patient. The devices have at least one impedance measuring element functionally connected to a programmable element, programmed to analyze an impedance measurement, and to provide an assessment of at least one respiratory parameter of the patient. Preferably the device includes electronics which aid in calibration, signal acquisition, conditioning, and filtering.

Medical device for glucose monitoring or regulation

A medical device comprising a pressure generating means adapted to displace a liquid, a sensor adapted to measure a flow resistance, and an implantable member comprising an analyte responsive porous membrane which reversibly changes its porosity subject to changes in analyte concentration occurring in the solution surrounding the implantable member. The analyte may in particular be glucose. The medical device may also be used for drug administration.

Apparatus and method for medication delivery using single input-single output (siso) model predictive control

A method includes receiving measurements from a sensor associated with a patient at a portable medication delivery device. The method also includes controlling delivery of medication to the patient at the portable medication delivery device using a single input, single output (SISO) model predictive control technique. The SISO model predictive control technique includes predicting a characteristic of the patient using the measurements and a model associated with the patient. The SISO model predictive control technique also includes determining whether the characteristic of the patient is predicted to fall outside of a desired range. In addition, the SISO model predictive control technique includes, if the characteristic of the patient is predicted to fall outside of the desired range, determining an amount of medication to deliver to the patient and delivering the determined amount of medication to the patient.

Blood Flow Monitoring

The present invention relates to a method of utilizing photoplethysmography obtained from a central site and a non-central site to detect a low blood flow or low blood volume condition. Also disclosed are apparatuses and systems designed to acquire and process physiological information based on photoplethysmograpy signal information from dual sites.

Device and Methods for Applying Therapeutic Protocols to Organs of the Cardiopulmonary System

The invention is a device for the introduction of a fluid into a human's airway. The air so introduced has a carefully modulated envelope of pressure vs. time, this envelope generally consisting of sequences of pressurized air packets of controlled frequency and pressures. The device produces these packets by means of pressurized air occluded by a shutter action which “chops” and interrupts the fluid stream. The vibrations induced by the device within human organs have been shown to have beneficial effects on various bodily systems, such as increase in heart rate variability, increase in absorbed oxygen, decrease in absorbed CO2, and the like.

Automated Therapy System and Method

An automated therapy system having an infusion catheter; a sensor adapted to sense a patient parameter; and a controller communicating with the sensor and programmed to control flow output from the infusion catheter into a patient based on the patient parameter without removing fluid from the patient. The invention also includes a method of controlling infusion of a fluid to a patient. The method includes the following steps: monitoring a patient parameter with a sensor to generate a sensor signal; providing the sensor signal to a controller; and adjusting fluid flow to the patient based on the sensor signal without removing fluid from the patient.

Determination and application of glucose sensor reliability indicator and/or metric

Disclosed are a system and method for determining a metric and/or indicator of a reliability of a blood glucose sensor in providing glucose measurements. In one aspect, the metric and/or indicator may be computed based, at least in part, on an observed trend associated with signals generated by the blood glucose sensor.

Device, system and method for meal detection for interfacing with and controlling auxiliary devices associated therewith

The present invention relates to a device, system and method for detecting meal event in a subject and in particular to such a device, system and method for communicating and controlling auxiliary devices and/or systems associated therewith.

Adhesive and peripheral systems and methods for medical devices

Fill stations and base stations are provided for personal pump systems. The fill stations may be opened and closed to accept a reservoir and to allow fluid to be introduced into the reservoir for use with personal pump systems. The fill stations may hold the reservoir at a tilt relative to an underlying surface and may discourage overfilling of the reservoir. The filling stations may also include viewing windows having fluid lines marked thereon for indicating volume of fluid within the reservoir.

Adaptable oxygen regulator system and method with an electronic control device

A system and method for an adaptable oxygen regulator with an electronic control device is disclosed. In one embodiment, an oxygen regulator system includes an electronic control device which includes a non-volatile memory for storing a first reference point. The electronic control device also includes a pressure sensor configured for generating pressure data of the pressurized aircraft cabin. The electronic control device further includes a logical control unit for generating a control signal by processing the first reference point and the pressure data. Further, the electronic control unit includes a rotary actuator for generating a rotary displacement based on the control signal. Moreover, the oxygen regulator system includes a demand dilution oxygen regulator coupled to the electronic control unit and configured to control the supply of oxygen and the flow of dilution air from the pressurized aircraft cabin based on the control signal.

Injection device with puncture function, method for controlling injection device with puncture function, chemical solution administration device, and method for controlling chemical solution administration device

An injection device with a puncture function includes, in a single casing, a cylindrical cartridge in which insulin is enclosed, a cartridge holder to which the cartridge is inserted, a needle inserted at a front end of the cartridge, a reciprocation unit for reciprocating the cartridge toward the needle, and an extrusion member for extruding the insulin from a rear end of the cartridge toward the needle, and the motion speed and the motion amount of the reciprocation unit are made variable.

Method and apparatus for machine error detection by combining multiple sensor inputs

One of the most significant safety concerns in the automation of extracorporeal blood treatments such as dialysis is the risk of blood leakage. Extracorporeal blood treatment systems draw blood at such a high rate that a loss of integrity in the blood circuit can be serious. There are a number of mechanisms for detecting and preventing leaks, but none is perfect. This tends to limit the use of such equipment in unsupervised settings, such as the home will be limited. Some leak detection schemes can be made sensitive enough to detect the barest of leaks, but when this is done, they result in too many false positives. The invention combines information from multiple inputs to enhance sensitivity in leak detection and reduce the problem of false positives.

Patch-sized fluid delivery systems and methods

A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

Adhesive and peripheral systems and methods for medical devices

A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.

Use of Multiple Spontaneous Breath Types To Promote Patient Ventilator Synchrony

The present disclosure combines the advantages of a hybrid mode of ventilation with an automatic determination of an appropriate spontaneous breath type in response to one or more patient based criteria. Specifically, when the ventilator is delivering a spontaneous breath type, a determination may be made as to whether predetermined ventilatory criteria have been met. Based on the determination the ventilator may deliver one of any number of spontaneous breath types.

Shrouded Sensor Clip Assembly and Blood Chamber for an Optical Blood Monitoring System

An optical blood monitoring system includes a sensor clip assembly and a blood chamber. The blood chamber has an internal flow cavity for extracorporeal blood flow and viewing lenses to enable the sensor clip assembly to monitor the blood when it is mounted on the blood chamber. The sensor clip assembly includes an annular shroud surrounding the LED emitters and another annular shroud surrounding the photodetectors, both for the purpose of blocking ambient light and limiting light piping. The blood chamber includes separate, distinct shroud mating surfaces to engage the shrouds on the sensor clip assembly.

Bodily fluid composition analyzer with disposable cassette

Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.

Systems and Methods for Diagnosing and Treating Sleep Disorders

A method for diagnosing and treating sleep disorders with a sleep therapy auto-titrator for in-home use by the patient includes the step of collecting, recording and analyzing sleep data in real time with the auto-titrator. Corrective action is provided in real time to the patient to mitigate sleep events based upon the collected sleep data. The collected sleep data is transmitted, via a global computer information system, to a remote server for storage. The stored sleep data is analyzed by a computer programmed with an algorithm to monitor therapy effectiveness daily and for identifying one or more therapy intervention recommendations. An alert is provided to at least one of the patient or a sleep therapy professional associated with the patient communicating the one or more intervention recommendations.

Microfluidic device and method of use

A microfluidic device and sensing method that utilize a resonating tube configured to have sufficient sensitivity to be capable of sensing the volume of a gas present as bubbles in a liquid or the flow rate and/or density of a gas or gas mixture flowing through the tube. The tube has a freestanding tube portion supported above a surface of a substrate so as to be capable of vibrating in a plane normal to the surface of the substrate. As a gas-containing fluid flows through an internal passage of the tube, a drive signal vibrates the freestanding tube portion at a resonant frequency thereof. Coriolis-induced deflections of the freestanding tube portion are sensed relative to the substrate to produce an output corresponding to the sensed deflections, and the drive signal and/or the output are assessed to determine the volume, density and/or flow rate of the gas of the gas-containing fluid.

Advanced analyte sensor calibration and error detection

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Infusion Pump Systems and Methods

Some embodiments an infusion pump system can be used to determine a user's total insulin load (TIL) that provides an accurate indication of the insulin previously delivered to the user's body which has not yet acted. In particular embodiments, the TIL can account for both the bolus deliveries and the basal deliveries that have occurred over a period of time. Such information may be useful, for example, when the infusion pump is operated in conjunction with a continuous glucose monitoring device.

Integrated delivery device for continuous glucose sensor

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

Activity Sensing Techniques for an Infusion Pump System

Some embodiments of a wearable infusion pump system can include a pump device having a drive system to dispense a medicine to a user, an activity sensor that detects a possible change in an activity level of the user, and a controller to activate the drive system to dispense the medicine to the user. The controller device can query the user to indicate whether a detected activity level of the user represents an actual change in the activity level of the user. The controller device can alter the medicine dispensing schedule based on the user indicated changes in activity level.

Optical sensing systems and methods

An optical glucose sensor may include an optical fiber and a glucose-permeable membrane having a hollow interior and being coupled to the optical fiber's distal end. The membrane's hollow interior provides a compartment to house a competitive glucose binding affinity assay. The assay may include a glucose analog that may be labeled with a dye, and a glucose receptor that may be labeled with a fluorophore. The optical fiber may include a compound parabolic concentrator tip, and the compartment may additionally house a reflector disposed so as to face the optical fiber's tip. A fluorophore-labeled assay may be interrogated by an optical interrogating system including a light source and a filter substrate having one or more coatings to effect, e.g., an excitation filter and/or an emission filter. The interrogating system may be manufactured as a stacked planar integrated optical system and diced into smaller units.

Portable infusion pump and media player

Some embodiments of a portable infusion pump system can be configured to deliver medicine (e.g., insulin or the like) to a user and to deliver media content to a user. The media content can include, for example, MP3 music and other audio/video data stored in a memory device in the portable system. Thus, in particular embodiments, the portable infusion pump system can serve a dual purpose of providing medication and entertainment for the user from a compact and unobtrusive device.

System and Method for Monitoring Time Intervals During Blood Parameter Monitoring

A system and method for monitoring at least one blood parameter of the blood of different patients, comprising a plurality of access devices for establishing at least one means of access to the blood of each patient through the skin, a plurality of removal devices for removing a quantity of blood from each patient in order to obtain at least one blood sample, at least one blood analysis device for analysing the blood sample with respect to predeterminable blood parameters and for generating individual blood parameter data sets, a calculation device which can be used jointly for a plurality of blood parameter data sets of different patients for calculating data sets of drug parameters of the drugs to be administered to the respective patient on the basis of the individual blood parameter data sets, and a plurality of supply devices for supplying the respective drug having the calculated drug parameters.

Method of monitoring safety in medication delivery for diabetes management

Glucose sensor signals and medication delivery control signals are monitored and these signals are modified for compatibility and safety purposes. In one application, output control signals from a controller directed to a delivery device are modified as a function of an actual amount of insulin delivered to the user. The safety layer method allows for an increased level of safety in an integrated delivery management (“IDM”) system and permits the development of separate hardware and software upgrades for components of the IDM system while assuring that compatibility between components will continue and safety is increased.

Ventilator component module

A ventilator comprising a ventilator component module. The component module includes a receiver for receiving a communication from a medical entity, a transmitter for transmitting ventilator information to the medical entity, a processor, memory, a touch screen, and a scanner configured for scanning identifiers.

Anesthetic Inhalation Aid Device and Attachment Used for the Same

An inhalation mask, an artificial nose unit, an anesthetic gas concentration detector, an extension tube, an anesthesia attachment, and an elastic bag are in communicative connection in sequence. The elastic bag has a mixing chamber formed therein and has an anesthetic inlet, an air inlet, and an outlet port each formed at the boundary to the exterior. The anesthesia attachment includes a hollow structure and an evaporation injector syringe. The outlet port of the elastic bag is in communicative connection with the hollow structure through its opening, and the evaporation injector syringe tightly mates with the interior of another opening. The anesthetic introduced into the mixing chamber is vaporized and then mixed with air introduced from the air inlet into mixed gas. The mixed gas is supplied from the outlet port to the inhalation mask by compressing the elastic bag or other procedures.

Method and Apparatus for Controlled Reoxygenation

A method and apparatus for performing coronary perfusion and cardiac reoxygenation that enables accurate control of oxygen levels in blood used for the coronary circulation. Deoxygenated blood and oxygenated blood are collected and oxygen levels are measured by sensors. The deoxygenated and oxygenated blood is then mixed and the mixed blood is measured by another sensor. The sensors provide data used to provide real-time oxygen level measurement and adjustment for blood supplied for coronary circulation.

Oxygen regulation with at least two spo2 monitors and automatic recognition of a signal having a higher rating

A process and a device for oxygen regulation of a patient having at least two SPO 2 monitors and a control for automatic recognition of which measurements are more reliable. The measurement from one or more of the two SPO 2 is used to control the oxygen concentration delivered to a patient based on a comparison of the measurements from the at least two SPO 2 monitors.

Fluid injection and safety system

Various medical systems and methods are described, including a medical monitoring system. The medical monitoring system can have a fluid system configured to receive bodily fluid and optically analyze said fluid to determine analyte concentration. The fluid system can have a removable portion. The removable portion can have an opening with a port. The system can also have a container configured to contain anticoagulant. The container can have a portion configured to mate with the port of the removable portion. The container can be further configured to not fit into a conventional luer fitting. An anti-coagulant insertion apparatus is also described. The apparatus can have a syringe, a dock with a port, and an adapter configured to connect the syringe to the port. The dock can also have a tab configured to move with the port.

Handheld Diabetes Manager With A User Interface For Displaying A Status Of An External Medical Device

A handheld diabetes manager has a graphical user interface for displaying status of an external medical device and includes a port configured to receive a test strip and a blood glucose measurement module. The diabetes manager includes a communications module that selectively communicates via a wireless data link with an external medical device to receive status data pertaining to the operation of the external medical device, and a user interface module in data communication with the blood glucose measurement module and the communications module. The graphical user interface includes a status screen that presents data pertaining to a glucose measure determined by the blood glucose measurement module concurrently with the status data received from the external medical device, such that the status data of the external medical device is presented on the status screen only when the communication module is in data communication with the external medical device.

Apparatus, system, and method for modulating consolidation of memory during sleep

Devices, systems and methods to modify memory and/or cognitive function by delivering a sensory stimulus paired with learned material at opportune physiological periods during sleep. For example, described herein are systems, methods and devices to enhance a user's cognitive function in such areas as memorization and learning. A machine (e.g., a system or device) may be used to identify opportune periods of the sleep cycle and to deliver a stimulus during specific phases of the sleep cycle to facilitate or interrupt memory consolidation. In some variations the machine records ambient sensory inputs during awake acquisition or reinforcement/relearning and replays all or an extracted form of the ambient sensory stimuli a specified portion of the user's sleep.

Modularized respiratory treatment apparatus

A modularized respiratory treatment apparatus provides various respiratory pressure treatments. The apparatus may be formed by discrete connectable modules such as a flow generator module, alarm module and/or humidifier module. Each module may include its own external casing or housing to independently retain or enclose the respective components that serve the function of the module. Different modules may be adapted with different components and functionalities and may be readily coupled using standardized gas and electrical connection configurations that have flow and communication paths that extend through the modules. When coupled, operation of the respiratory treatment apparatus may be controlled by detection of different modules, such as the alarm module that generates visual and/or audible alarms based on detected conditions, so as to selectively enable or disable different respiratory treatments. The discrete modules of the medical treatment apparatus may include tamper resistant locking mechanisms to impede unauthorized separation of some modules.

Sensing systems and methods

A fluidic media detection system for detecting a presence of fluidic media includes a first housing portion adapted to be carried by a user; a second housing portion configured to be selectively operatively engaged with and disengaged from the first housing portion, the second housing portion for supporting a reservoir having an interior volume for containing fluidic media; a fluid conduit supported by one of the first housing portion and the second housing portion for providing fluid communication between the reservoir and the user when the first housing portion and the second housing portion are operatively engaged; and at least one interactive element, positioned near a portion of the fluid conduit, that interacts with the fluidic media when the fluidic media is present in the fluid conduit.

Smart power strip

A power strip includes a controller that controls the transfer of electricity to one or more outlet electrical connectors based at least in part on a set of rules and certain status information. Some embodiments provide for apparatuses and methods of controlling the transfer of electricity to one or more outlet electrical connectors of a power strip based on various status information, such as cost, personal preferences, time information, power consumption.

Hypersaturation index

Embodiments of the present disclosure provide a hypersaturation index for measuring a patient's absorption of oxygen in the blood stream after a patient has reached 100% oxygen saturation. This hypersaturation index provides an indication of the partial pressure of oxygen of a patient. In an embodiment of the present invention, a hypersaturation index is calculated based on the absorption ratio of two different wavelengths of energy at a measuring site. In an embodiment of the invention, a maximum hypersaturation index threshold is determined such that an alarm is triggered when the hypersaturation index reaches or exceeds the threshold. In another embodiment, an alarm is triggered when the hypersaturation index reaches or falls below its starting point when it was first calculated.

Multimodal dialysis system

A dialysis device for operation in multiple modes and for maintaining a known gradient of potassium ion or other electrolyte between the blood of a patient and a dialysate fluid is described. The dialysis device is capable of being used for hemodialysis or peritoneal dialysis, and the dialysis device is capable of operation with a dialysate purification unit outside of a clinical setting or with a supply of water that can be supplied in a clinical setting. The dialysis device has a composition sensor containing a potassium-sensitive electrode for measuring a potassium ion concentration in one or more of the patient's blood and the dialysate fluid and an infusate pump operated to adjust a potassium ion concentration in the dialysate fluid based at least in part on data from the composition sensor.

Drug Delivery System And Method For Conscious Sedation/Analgesia

Inhalant anesthetics are developed with a number of properties including rapid onset and recovery, controllability, and, ideally, a broad safety profile. The efficacy of these agents is measured by their ability to create anesthesia within the framework of the other desirable properties. The instant invention focuses on the dosage level where analgesia occurs but amnesia or lack of consciousness does not. In addition to identifying the dosage level where pain is sharply reduced or eliminated but awareness remains, a delivery system for safe and effective delivery of the agent is described.

Modular external infusion device

A modular external infusion device that controls the rate a fluid is infused into an individual's body, which includes a first module and a second module. More particularly, the first module may be a pumping module that delivers a fluid, such as a medication, to a patient while the second module may be a programming module that allows a user to select pump flow commands. The second module is removably attachable to the first module.

Method and apparatus to attain and maintain target end tidal gas concentrations

In a first aspect, the invention relates to an apparatus for inducing or maintaining a target end tidal concentration of a gas in a subject comprising a breathing circuit, a source of gas flow into the circuit, means for controlling the rate of the source of gas flow into the circuit and means for controlling the concentration of gases in the source gas flow independently from each other. In another aspect, the invention relates to a method of preparing an apparatus for inducing or maintaining a target end tidal concentration of a gas X in a subject comprising selecting a rate of a source gas flow into a breathing circuit, selecting the concentration of at least one constituent gas of a component gas making up the source gas to a level corresponding to the end tidal concentration of the gas X, whereby the apparatus is adapted to administer a source gas having a first gas composition.

Method for transmitting data in a blood glucose system and corresponding blood glucose system

The present invention relates to a method for wireless transmission of data between components of a blood glucose system ( 1 , I 1 ) including a master controller ( 2, 2 ′) having a receiver ( 10 ) and a transmitter ( 9 ), and at least one slave device ( 3 ) having a receiver ( 19 ) and a transmitter ( 18 ). The slave device ( 3 ) is normally operated in a power saving mode and its receiver ( 19 ) is only activated intermittently at a receiver activation frequency for a predetermined listening period. The controller ( 2, 21 ) transmits a communication initiation data frame to the slave device ( 3 ) via a preamble signal transmitted for a preamble period. Upon receipt of the communication initiation data frame, the slave device ( 3 ) is switched to a communication mode in which it transmits a response to the controller ( 2, 21 ), and the slave device ( 3 ) is switched from the communication mode to the power saving mode.

Tracking ventilator information for reporting a ventilator-associated event

A method for tracking ventilator information for clinical process improvement or reporting of a ventilator-associated event. The method includes receiving rules for reporting a ventilator-associated event; configuring threshold values corresponding to the rules; comparing ventilator information obtained during patient care with the rules and the threshold values; and generating an output of the comparison of said ventilator information with the rules and the threshold values.

Childbirth labor coach with paced breathing

A system ( 10 ) configured to prompt a subject ( 12 ) to consciously alter one or more breathing parameters during childbirth. The system includes a pressure generator ( 14 ) that generates a pressurized flow of breathable gas for delivery to an airway of the subject during childbirth and a processor ( 22 ) that controls the pressure generator to adjust one or more gas parameters of the gas in the pressurized flow of breathable gas to provide breathing cues to the subject in accordance with a breathing regime associated with labor contractions, wherein the breathing cues prompt the subject to consciously alter one or more breathing parameters of respiration.

Patch-sized fluid delivery systems and methods

A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

Ventilator-initiated prompt regarding detection of fluctuations in compliance

This disclosure describes systems and methods for monitoring and evaluating ventilatory data to provide useful notifications and/or recommendations. Indeed, many clinicians may not easily identify or recognize data patterns and correlations indicative of certain patient conditions or the effectiveness of ventilatory treatment. Further, clinicians may not readily determine appropriate adjustments that may address certain patient conditions or the effectiveness of ventilatory treatment. Specifically, clinicians may not readily detect or recognize the occurrence of fluctuations in compliance during various types of ventilation. According to embodiments, a ventilator may be configured to monitor and evaluate diverse ventilatory parameters to detect an occurrence of and potential causes for fluctuations in compliance and may subsequently issue suitable notifications and/or recommendations. The suitable notifications and/or recommendations may further be provided in a hierarchical format such that the clinician may selectively access information regarding the fluctuation in compliance and/or potential causes for the fluctuation in compliance.

Integrated insulin delivery system with continuous glucose sensor

Systems and methods for integrating a continuous glucose sensor 12 , including a receiver 14 , a medicament delivery device 16 , a controller module, and optionally a single point glucose monitor 18 are provided. Integration may be manual, semi-automated and/or fully automated.

Fluid handling cassette

A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.

Safeguarding measures for a closed-loop insulin infusion system

Processor-implemented methods of controlling an insulin infusion device for a user are provided here. A first method obtains a current insulin on board (IOB) value that estimates active insulin in the user, and compensates a calculated insulin infusion rate in response to the obtained IOB value. A second method supervises the operation of a glucose sensor by obtaining and processing insulin-delivered data and glucose sensor data for the user. An alert is generated if the second method determines that a current glucose sensor value has deviated from a predicted sensor glucose value by at least a threshold amount.

Usability features for integrated insulin delivery system

Various systems and methods for improving the usability of continuous glucose monitors and drug delivery pumps are described.

Advanced analyte sensor calibration and error detection

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Clot evacuation and visualization devices and methods of use

An integrated clot evacuation device having visualization for use in neurosurgical applications, particularly for the evacuation of clots formed as a result of intracranial hemorrhage (ICH). The device may further include an integrated camera and light for visualizing the interior of the brain and the clot itself. Further, the device is configured to evacuate clots through aspiration and irrigation.

AR/VR/XR ASSISTANCE

A reality system includes a display aimed at a retina, the display providing 3D images with different depth view points; a glass to selectably turn on or off view of an outside environment in front of the person's eye; a processor coupled to the camera and to the glass to selectably switch between augmented reality and virtual reality; and a wireless transceiver coupled to the transceiver to communicate with a remote processor. 1. A reality system comprising:a display lens removably contacting an eye;a processor coupled to a cameras and to the display lens, the processor providing visual assistance to the person by running code for panorama stitching, the processor further providing augmented vision including automated object recognition and facial recognition with limited information processing by determining a position and shape of an object based on edge locations in time-correlated images from two cameras, and determining motion from successive pairs of images after subjecting the images to edge detection or thresholding and then scaling, cropping or centering the recognized object or face to aid the person; anda wireless transceiver coupled to the transceiver to communicate with a remote processor.2. The system of claim 1 , wherein the remote processor is in a mobile phone claim 1 , and wherein the processor selectably switches between augmented reality and virtual reality claim 1 , the processor includingcode to perform motion tracking and understanding an environment with points or planes using accelerometer sensor and estimating light or color in the environment using one video camera without a depth sensor in a mobile phone;code to capture images from a plurality of angles of the environment;code to acquire sensor data from sensors and optimize features extracted from each image and sensor data, where a feature conveys data unique to the image at a specific pixel location, comprising: a learning machine that determines content to be presented based on ...

SYSTEMS AND METHODS USING ESTIMATED GLOMERULAR FILTRATION RATES OF THE KIDNEYS IN THE NON-STEADY STATE

A system and method of determining the estimated glomerular filtration rate of the kidneys of a patient. The system and method obtains patient medical data, determines constants based on the patient medical data and using exactly one of the MDRD equation or the Cockroft-Gault equation, and determines the estimated glomerular filtration rate based on a relationship of measured creatinine levels and the determined constants. The estimated glomerular filtration rate is used to determine the dose of a medication of a type filtered by the kidneys, determine a temporal correlation of the introduction of a drug into a patient with changes in kidney function, determine the administration rate for dosing intravenous fluids, determine the efficacy of a medical treatment, and determine kidney function after transplantation or injury. 2. The computer-implemented method of claim 1 , wherein determining the dose further comprises:determining a standard dose of medicine for the patient based on one or more medical data; anddetermining an adjustment to the standard dose of medicine based at least in part on the estimated glomerular filtration rate of the kidney, andwherein the dose is the standard dose modified by the adjustment to the standard dose.3. The computer-implemented method of claim 1 , wherein determining the dose further comprises:determining a preferred blood concentration of the medicine for the patient; anddetermining the dose of medicine needed to attain the preferred blood concentration of the medicine in the patient.4. The computer-implemented method of claim 1 , wherein determining the dose further comprises:determining a preferred blood concentration of metabolites of the medicine for the patient; anddetermining the dose of medicine to needed attain the preferred blood concentration of metabolites of the medicine in the patient.5. The computer-implemented method of claim 1 , wherein determining the dose further comprises:determining a preferred range of blood ...

DRUG DELIVERY DEVICE

A system and method provide for enhanced reliability and safety of programming and/or operating a medical device, such as an infusion pump. 120-. (canceled)21. A method of providing closed loop therapy to a patient with an ambulatory infusion pump system , comprising:storing at least one acceptable operation parameter for closed loop delivery of medicament with an ambulatory infusion pump, the at least one acceptable operation parameter related to a timing of automatic delivery of a bolus of medicament;receiving glucose level data of a user from a continuous glucose monitor system;comparing the glucose level data of the user to a high glucose threshold;determining, based on the comparison of the glucose level data of the user to the target glucose level, that an automatic bolus delivery of medicament is needed to lower the user's glucose level below the high glucose threshold;determining whether automatic delivery of the bolus delivery of medicament is permissible based on the at least one acceptable operation parameter related to a timing of automatic delivery of a bolus of medicament; andpreventing an ambulatory infusion pump from automatically delivering the bolus delivery of medicament if it is determined that the bolus delivery of medicament is not permissible based on the at least one acceptable operation parameter related to a timing of delivery of a bolus of medicament.22. The method of claim 21 , further comprising enabling the ambulatory infusion pump to deliver the bolus delivery of medicament if it is determined that the bolus delivery of medicament is permissible based on the at least one acceptable operation parameter related to a timing of delivery of a bolus of medicament.23. The method of claim 21 , wherein the device that determines that the bolus delivery of medicament is needed to lower the user's glucose level below the high glucose threshold is a remote control device of the ambulatory infusion pump system.24. The method of claim 21 , wherein ...

SENSING CATHETERS

A catheter system may include a catheter lumen, first and second electrodes, and a sensor in communication with the first and second electrodes. The sensor may be configured to detect at least one of: a bulk volume of blood within a blood vessel and extravasation of a drug from the blood vessel into soft tissue adjacent the blood vessel. Other catheter systems may include a catheter lumen and a sensing chip coupled to the catheter lumen. The sensing chip may be configured to detect at least one of: a bulk volume of blood within a blood vessel and extravasation of a drug from the blood vessel into soft tissue adjacent the blood vessel. 1. A catheter system comprising: [ a proximal end;', 'a distal end;', 'an inner lumen surface; and', 'an outer lumen surface; and, 'a catheter lumen comprising, 'a first electrode coupled to the catheter lumen; and', 'a second electrode coupled to the catheter lumen; and, 'a catheter, the catheter comprisinga drug sensor in communication with the first and second electrodes coupled to the catheter lumen, at least a portion of the first and second electrodes are embedded within a soft tissue of the patient adjacent the blood vessel,', 'the first and second electrodes are in communication with each other through the soft tissue of the patient between the first and second electrodes, and', 'the drug sensor detects whether extravasation of a drug has occurred from the blood vessel into the soft tissue of the patient by sensing a characteristic associated with the soft tissue of the patient, the characteristic comprising at least one of inductance, impedance, and capacitance., 'wherein when the distal end of the catheter lumen is inserted into a blood vessel of a patient2. The catheter system of claim 1 , further comprising:a first attachment feature configured to electrically couple the drug sensor to the first electrode; anda second attachment feature configured to electrically couple the drug sensor to the second electrode.3. The ...

METHODS OF INCORPORATING CGM DATA INTO DIABETES THERAPY

Disclosed herein are apparatuses and methods incorporating an infusion pump and a CGM that can include software that automatically populates a blood glucose section of a bolus calculator with a most recent valid CGM value. The software can additionally be programmed to automatically populate the bolus calculator with a single CGM reading only when one or more predefined conditions are met that aid in mitigating the risk of inaccurate and/or invalid single CGM readings. 1. An ambulatory infusion pump system , comprising:a pump mechanism configured to facilitate delivery of insulin to a user;a user interface;a communications device adapted to receive glucose levels from a continuous glucose monitor; automatically calculate insulin doses with a closed loop delivery algorithm based on glucose levels received from the continuous glucose monitor;', 'deliver the calculated insulin doses to the user with the pump mechanism;', 'display a bolus programming feature for programming a bolus delivery of insulin to the user;', 'determine whether the closed loop delivery algorithm supports an auto-population feature;', 'determine whether the bolus programming feature was manually accessed by the user;', 'determine whether the glucose levels received from the continuous glucose monitor are valid; and', 'activate the auto-population feature to automatically populate a blood glucose field in the bolus programming feature with a most recent glucose level received from the continuous glucose monitor only if the closed loop delivery algorithm supports the auto-population feature, the bolus programming feature was manually accessed by the user and the glucose levels received from the continuous glucose monitor are valid., 'a processor functionally linked to the pump mechanism, the user interface and the communications device, the processor configured to2. The system of claim 1 , wherein determining whether the glucose levels received from the continuous glucose monitor are valid includes ...

Sustained variable negative pressure wound treatment and method of controlling same

Disclosed herein are systems and methods for providing reduced or negative pressure, and more particularly cyclical reduced pressure, to treat a wound. The system can include a wound dressing, a fluid collection container, a suction source, filters, and conduits. In addition, the system can include a control device and sensors. The sensors may be configured to monitor certain physiological conditions of a patient such as temperature, pressure, blood flow, blood oxygen saturation, pulse, cardiac cycle, and the like. Application of cyclical reduced pressure between two or more values below atmospheric pressure may be synchronized with the physiological conditions monitored by the sensors. Certain embodiments of the system utilize an air reservoir and one or more valves and pressure sensors or gauges to allow for rapid cycling of the level of reduced pressure within the wound dressing between two or more reduced pressure values.

Portable Lung Assist Device

The present invention relates to a portable lung assist device. In one embodiment, the portable lung assist device comprises an integrated oxygenator, blood pump, and cannula. In one embodiment, the portable lung assist device of the present invention does not require an oxygen tank, but instead can provide oxygen to a subject's blood from ambient air. In one embodiment, at least a portion of the portable lung assist device, for example the cannula can be implantable. In one embodiment, the cannula of the device of the present invention can be inserted in to the subject's pulmonary artery. A method for providing portable lung assistance is also described. 1. A portable lung assist device , comprising:an oxygenator, having a first chamber and a second chamber, the first chamber having an inlet and an outlet, the second chamber having an inlet and an outlet, and a membrane separating the first chamber and the second chamber;a means for supplying a sweep gas to the inlet of the first chamber of the oxygenator;a cannula, having a first lumen and a second lumen; anda pump;wherein the first lumen is connected to the pump, the pump is connected to the inlet of the second chamber of the oxygenator via a third lumen, and the second lumen is connected to the outlet of the second chamber of the oxygenator;wherein when the first lumen and second lumen are also connected to a blood vessel of a subject, blood can flow from the subject through the first lumen, through the pump, through the third lumen, through the second chamber of the oxygenator, and through the second lumen back into the subject; andwherein the subject's blood can be oxygenated via transfer of oxygen across the membrane in the oxygenator.2. The device of claim 1 , wherein the sweep gas is air.3. The device of claim 1 , wherein at least a portion of the cannula is surgically implantable.4. The device of claim 1 , wherein the means for supplying a sweep gas to the oxygenator is a fan.5. The device of claim 1 , ...

Method and device to monitor patients with kidney disease

A medical monitoring device for monitoring electrical signals from the body of a subject is described. The medical monitoring device monitors electrical signals originating from a cardiac cycle of the subject and associates each cardiac cycle with a time index. The medical monitoring device applies a forward computational procedure to generate a risk score indicative of hyperkalemia, hypokalemia or arrhythmia of the subject. The medical monitoring device can adjust the forward computational procedure based upon clinical data obtained from the subject.

BASAL RATE TESTING USING FREQUENT BLOOD GLUCOSE INPUT

An apparatus comprising a user interface configured to generate an electrical signal to start a basal insulin rate test when prompted by a user, an input configured to receive sampled blood glucose data of a patient that is obtained during a specified time duration, including a time duration during delivery of insulin according to a specified basal insulin rate pattern, and a controller communicatively coupled to the input and the user interface. The controller includes an insulin calculation module configured for determining at least one of an amount of basal insulin over-delivered and an amount of basal insulin under-delivered during the basal insulin rate test in trying to meet a target blood glucose baseline. Other devices and methods are disclosed. 1. An apparatus comprising:a user interface configured to generate an electrical signal to start a basal insulin rate test when prompted by a user;an input configured to receive sampled blood glucose data of a patient that is obtained during a specified time duration, including a time duration when insulin is delivered according to a specified basal insulin rate pattern; anda controller communicatively coupled to the input and the user interface, the controller including an insulin calculation module, wherein the insulin calculation module is configured to determine at least one of an amount of basal insulin over-delivered and an amount of basal insulin under-delivered during the basal insulin rate test in trying to meet a target blood glucose baseline.2. The apparatus of claim 1 , wherein the insulin calculation module is configured to determine the over-delivered amount and the under-delivered amount using a correction factor of the patient and a variance of a blood glucose level from the target blood glucose baseline.3. The apparatus of claim 2 , wherein the insulin calculation module is configured to determine the over-delivered amount and the under-delivered amount using an adjusted correction factor of the ...

SYSTEMS AND METHODS FOR MODEL-BASED OPTIMIZATION OF MECHANICAL VENTILATION

A mechanical ventilator () is connected with a ventilated patient () to provide ventilation in accordance with ventilator settings of the mechanical ventilator. Physiological values (variables) are acquired for the ventilated patient using physiological sensors (). A ventilated patient cardiopulmonary (CP) model () is fitted to the acquired physiological variables values to generate a fitted ventilated patient CP model by fine-tuning its parameters (). Updated ventilator settings are determined by adjusting model ventilator settings of the fitted ventilated patient CP model to minimize a cost function (). The updated ventilator settings may be displayed on a display component () as recommended ventilator settings for the ventilated patient, or the ventilator settings of the mechanical ventilator may be automatically changed to the updated ventilator settings so as to automatically control the mechanical ventilator. 1. A medical ventilator system comprising:a mechanical ventilator connected with a ventilated patient to provide ventilation to the ventilated patient in accordance with ventilator settings;physiological sensors configured to acquire measured values for the ventilated patient of monitored physiological variables;a cardiopulmonary modeling component comprising a microprocessor programmed to generate computed values for the ventilated patient of unmonitored physiological parameters based on the measured values for the ventilated patient of the monitored physiological variables and the ventilator settings,wherein the CP modeling component is programmed to generate the computed values for the ventilated patient of the unmonitored physiological parameters by operations includingfitting a ventilated patient CP model to the ventilated patient by fitting predictions of the ventilated patient CP model for the monitored physiological variables to the measured values for the ventilated patient of the monitored physiological variables in order to generate a fitted ...

MEDICINE INJECTION AND DISEASE MANAGEMENT SYSTEMS, DEVICES, AND METHODS

One or more embodiments of the present disclosure may include an insulin delivery system that includes an insulin delivery device, a user interface that includes multiple user-selectable icons or buttons each representing different meal characteristics, memory to store one or more user-specific dosage parameter, and a processor in communication with the memory and adapted to receive blood glucose data. The processor may also be adapted to determine initial meal characteristics associated with each of the user-selectable icons or buttons based on at least one of the user-specific dosage parameters. The processor may also be adapted to update the meal characteristics associated with each of the user-selectable icons or buttons based upon the blood glucose data. 1. An insulin delivery system comprising:an insulin delivery pen;a glucose monitor or sensor; a user interface adapted to display a correction dosage recommendation and dosage recommendations for a plurality of different meal characteristics;', 'memory to store one or more user-specific dosage parameter; and', 'a processor in communication with the memory and adapted to receive blood glucose data from the glucose monitor or sensor, the processor being adapted to determine recommended doses based on the one or more user-specific dosage parameters and the received blood glucose data., 'a cap for the insulin delivery pen, the cap comprising2. (canceled)3. The insulin delivery system of claim 1 , wherein the glucose monitor or sensor is a flash glucose monitor comprising a flash near field communication circuit claim 1 , wherein the cap further comprises a system near field communication circuit in communication with the processor claim 1 , wherein the processor is adapted to receive the blood glucose data via near field communications (NFC) when the system near field communication circuit and the flash near field communication circuit are brought within an NFC communication distance.4. (canceled)5. The insulin ...

SYSTEMS, DEVICES, AND METHODS FOR TREATING VESTIBULAR CONDITIONS

Apparatus and methods are described herein that provide a vibratory device that can apply a vibratory signal to a portion of a head of a user such that the vibratory signal can be conducted via bone to a vestibular system of the user and cause a portion of the vestibular system to move in a manner equivalent to that of a therapeutically effective vibratory signal applied to an area overlaying a mastoid bone of the user. The vibratory device can be associated with frequencies less than 200 Hz. The vibratory device can be effective at treating a physiological condition associated with the vestibular system. 1. A method , comprising:applying, via a vibratory device positioned over an area of a head of a user, a vibratory signal to the area of the head of the user such that the vibratory signal can be conducted via bone to a vestibular system of the user, the vibratory signal configured to cause a portion of the vestibular system to move in a manner equivalent to that of a vibratory signal (1) applied to an area overlaying a mastoid bone of the user and having (2) a frequency less than 200 Hz and a force level greater than 87 dB re 1 dyne and less than or equal to 100 dB re 1 dyne; andtreating, in response to applying the vibratory signal to the area of the head of the user, a physiological condition associated with the vestibular system.2. The method of claim 1 , wherein the vibratory device has a resonant frequency claim 1 , the method further comprising:supplying an electrical signal to the vibratory device to cause the vibratory device to vibrate to generate the vibratory signal that is applied to the area of the head of the user, the electrical signal having a signal frequency;measuring, using a sensor, information including at least one of: a current of the electrical signal, a voltage change of the electrical signal across the vibratory device, a magnetic field generated near the vibratory device, and an acceleration of the vibratory device; andadjusting the ...

SUSTAINED VARIABLE NEGATIVE PRESSURE WOUND TREATMENT AND METHOD OF CONTROLLING SAME

Disclosed herein are systems and methods for providing reduced or negative pressure, and more particularly cyclical reduced pressure, to treat a wound. The system can include a wound dressing, a fluid collection container, a suction source, filters, and conduits. In addition, the system can include a control device and sensors. The sensors may be configured to monitor certain physiological conditions of a patient such as temperature, pressure, blood flow, blood oxygen saturation, pulse, cardiac cycle, and the like. Application of cyclical reduced pressure between two or more values below atmospheric pressure may be synchronized with the physiological conditions monitored by the sensors. Certain embodiments of the system utilize an air reservoir and one or more valves and pressure sensors or gauges to allow for rapid cycling of the level of reduced pressure within the wound dressing between two or more reduced pressure values. 115.-. (canceled)16. A method of operating a negative pressure wound therapy apparatus , the method comprising:applying, via a fluid flow path, reduced pressure from a suction source to a wound dressing placed over a wound;monitoring a temperature at the wound using a sensor positioned at least partly in the wound or the wound dressing or positioned adjacent to the wound dressing; andadjusting the reduced pressure from the suction source by cycling the reduced pressure from the suction source between two different negative pressure values according at least to the temperature at the wound.17. The method of claim 16 , wherein said adjusting comprises adjusting a frequency of the reduced pressure from the suction source according at least to the temperature at the wound.18. The method of claim 16 , wherein said adjusting comprises adjusting the reduced pressure from the suction source in response to determining that the temperature at the wound satisfies a threshold.19. The method of claim 16 , wherein said adjusting comprises adjusting the ...

STORAGE CASE WITH THE CAPABILITY OF COMMUNICATION AND MEDICAL DATA ACQUISITION

The invention relates to a medical data acquisition communication device (), comprising a housing (′) and electronics () arranged within the housing (′), the electronics comprising a power supply (); a processor unit (); a memory unit (); at least one short-range communication device (); at least one long-range communication device (); and a user interface () including at least one trigger signal generating element (). 1100. A medical data acquisition communication device () , comprising:{'b': '100', 'a housing (′); and'}{'b': 110', '100, 'claim-text': [{'b': '111', 'a power supply ();'}, {'b': '115', 'a processor unit ();'}, {'b': '116', 'a memory unit ();'}, {'b': '117', 'at least one short-range communication device ();'}, {'b': '119', 'at least one long-range communication device (); and'}, {'b': 120', '123, 'a user interface () including at least one trigger signal generating element (); wherein the long range communication device is'}], 'electronics () arranged within the housing (′), the electronics comprising'}(i) configured for wired communication, or{'b': '118', '(ii) configured for GPRS-based GSM communication and further comprises a SIM card ().'}2100100300400510520530. The communication device () according to claim 1 , wherein the housing (′) is configured to receive at least one further item selected from the group comprising medical measuring devices (′) claim 1 , drug delivery devices (′) claim 1 , lancets () claim 1 , injection needles () claim 1 , and blood glucose test strips ().3100300300400400. The communication device () according to claim 2 , wherein the medical measuring device (′) is a blood glucose meter () and the drug delivery device (′) is an insulin pen ().4100100300400. The communication device () according to claim 1 , wherein said communication device () is adapted to be used in cooperation with commercially available medical measuring devices (′) and/or drug delivery devices (′) without any modification of said devices.5100123. The ...

WIRE HEATED TUBE WITH TEMPERATURE CONTROL SYSTEM, TUBE TYPE DETECTION, AND ACTIVE OVER TEMPERATURE PROTECTION FOR HUMIDIFIER FOR RESPIRATORY APPARATUS

A PAP system for delivering breathable gas to a patient includes a flow generator to generate a supply of breathable gas to be delivered to the patient; a humidifier including a heating plate to vaporize water and deliver water vapor to humidify the supply of breathable gas; a heated tube configured to heat and deliver the humidified supply of breathable gas to the patient; a power supply configured to supply power to the heating plate and the heated tube; and a controller configured to control the power supply to prevent overheating of the heating plate and the heated tube. 1. A control system for a heated conduit for use in a respiratory apparatus , the control system comprising:a power supply to provide power to the heated conduit;an over-temperature control circuit to prevent the overheating of the heated conduit;a heating control circuit configured to control heating to obtain a predetermined temperature;a sensing circuit including a sensing resistor configured to indicate the temperature of a sensor positioned in the heated conduit; anda bias generator circuit configured to provide a first source voltage to the sensing circuit so that the temperature of the heated conduit is continuously monitored.2. A control system according to claim 1 , wherein the over-temperature control circuit comprises a first transistor switch that is turned on when the temperature is below the predetermined temperature and is turned off when the temperature is at or above the predetermined temperature.3. A control system according to claim 2 , wherein the predetermined temperature is between the range of about 30° C. and about 45° C.4. A control system according to claim 2 , wherein the over-temperature control circuit further comprises a first comparator that controls the switching of the first transistor switch by comparing a reference voltage representing the predetermined temperature to a voltage determined from a first amplifier of the sensing circuit.5. A control system ...

FIELD UPDATE OF AN AMBULATORY INFUSION PUMP SYSTEM

Portable or ambulatory infusion devices and systems capable of remotely updating an ambulatory fluid delivery device include safety protocols that verify the status of the ambulatory fluid delivery device before and after a field update of software. Methods of accomplishing the same field update of software are also described. 1. An ambulatory fluid delivery device , comprising:a user interface that a user operates to input directions and data that determine the dosing of a medicament to a patient;a liquid drug repository that contains the medicament;a pump fluidly connected to the liquid drug repository;an electrical controller configured to direct the pump to release the medicament; and data regarding administered doses of the medicament;', 'one or more device history logs of the fluid delivery device;', 'an operating system of fluid delivery device;', 'user profile information;', 'identifying information regarding the fluid delivery device; and', 'safety protocols for the fluid delivery device; and, 'a digital storage component, operably connected to the electrical controller, configured to store'} receive software updates sent from a qualified source;', 'verify the appropriateness of the software updates for the fluid delivery device based upon the identifying information and device history logs;', 'automatically install the software updates;', 'update the device history logs; and', 'perform tests conforming to the safety protocols after installation of the software., 'a signal processing component that sends and receives electrical data to and from the controller, wherein the fluid delivery device is configured to'}2. The ambulatory fluid delivery device of claim 1 , wherein software updates are received after the user requests the software update.3. The ambulatory fluid delivery device of claim 1 , wherein the software updates are automatically received by the ambulatory fluid delivery device.4. The ambulatory fluid delivery device of claim 1 , wherein the ...

Methods for generating and delivering droplets to the pulmonary system using a droplet delivery device

A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.

SYSTEMS, DEVICES AND METHODS FOR MANAGING GLUCOSE LEVELS

Systems, devices and methods for the management of glucose levels in the body of patient featuring user interface input mechanisms configured to provide haptic feedback to the user are provided. 1. A glucose management device , comprising:a processor; anda user interface controlled by the processor, the user interface comprising a user input mechanism configured for tactile contact and movement by a user for entering values of one or more parameters for controlling the glucose management device;wherein the user input mechanism is configured to provide a haptic feedback response to the user as the entered value of a selected parameter approaches a predefined limit.2. The glucose management device of claim 1 , wherein the haptic feedback response comprises a damping of movement of the user input mechanism wherein the extent of damping increases the closer the entered value approaches the predefined limit.3. The glucose management device of claim 2 , wherein the haptic feedback response further comprises locking the user input mechanism against further movement upon the entered value of the selected parameter exceeding the predefined limit.4. The glucose management device of claim 2 , wherein the user input mechanism is movable in at least two directions wherein movement in a first direction increases the value of the selected parameter and movement in a second direction decreases the value of the selected parameter.5. The glucose management system of claim 4 , wherein the user input mechanism is rotatable about an axis and the movement of the user input mechanism is rotational.6. The glucose management system of claim 5 , wherein the user input mechanism is further moveable in a linear direction transverse to the axis of rotation.7. The glucose management device of claim 1 , wherein the user input mechanism is a toggle button.8. The glucose management device of claim 1 , wherein the user interface comprises a display for displaying the values of the one or more ...

Infusion pump assembly

An infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw.

PERFORMANCE MONITORING OF REGIONAL CITRATE ANTICOAGULATION

A monitoring device operates to monitor regional citrate anticoagulation (RCA) in a blood treatment system which is configured to administrate citrate to an extracorporeal blood circuit () upstream of a dialyzer () during a treatment session. At consecutive time steps during the treatment session, the monitoring device obtains a current measurement value of systemic ionized calcium (iCa) or systemic total calcium (Ca), operates a predefined algorithm on the current measurement value to generate a current computation value that represents ionized calcium (iCa, iCa) in blood at a selected location (loc2, loc3) downstream or upstream of the dialyzer () in the extracorporeal blood circuit (), and presents and/or evaluates the current computation value for assessment of the regional citrate anticoagulation. The need for conventional blood sampling and blood analysis upstream and/or downstream of the dialyzer, e.g. during CRRT, is thereby reduced significantly. 127-. (canceled)28: A monitoring device for a blood treatment system , the blood treatment system comprising an extracorporeal blood circuit which comprises a blood withdrawal line and a blood return line for connection to a vascular system of a subject and a dialyzer intermediate the blood withdrawal and blood return lines , wherein the blood treatment system is configured for regional citrate anticoagulation by administration of citrate to the extracorporeal blood circuit upstream of the dialyzer during a treatment session , said monitoring device comprising:a memory; and obtain a current measurement value of systemic ionized calcium or systemic total calcium,', 'operate a predefined algorithm on the current measurement value to generate a current computation value that represents ionized calcium in blood at a selected location downstream or upstream of the dialyzer in the extracorporeal blood circuit, and', 'display, via a display device, the current computation value, and/or determine an assessment of the ...

FEEDBACK PREDICTIVE CONTROL APPROACH FOR PROCESSES WITH TIME DELAY IN THE MANIPULATED VARIABLE

This invention relates to a feedback predictive controller, systems comprising and methods employing the same. Preferably the feedback predictive controller and/or systems comprising the feedback predictive controller are part of an automatic insulin delivery system. The methods described herein can be used to control blood glucose concentration in a patient with diabetes. Preferably, the insulin delivery system is an artificial pancreas. 1. A method of using an insulin delivery system comprising steps of:determining an amount of insulin to administer using a feedback predictive control, wherein the feedback predictive control is stored on a machine readable non-transitory media; wherein the feedback predictive control comprises a first model and a second model; wherein the first model is a predictive model; and wherein the second model is a noise model, which models unmeasured disturbances and bias;providing a predictive input and a measured input to the first model;using the predictive input and measured input to provide a parametrized first model to provide an output, wherein the output is provided to the second model and to a PID controller, wherein the PID controller controls an insulin flow rate;providing feedback to the PID controller from the second model;administering insulin using the insulin delivery system based on the output and the feedback, wherein the administration of insulin is adjusted to nullify the effect of any disturbances on blood glucose concentration based on a predicted blood glucose value.2. The method of wherein the measured input is provided by an automatic monitoring system.3. The method of wherein the predictive input is provided manually by a user.4. The method of wherein the insulin delivery system is a wearable device claim 1 , an artificial pancreas claim 1 , or a combination thereof.5. The method of wherein the automatic monitoring system comprises one or more sensors comprising at least one of the following a soft sensor claim 2 ...

METHOD FOR CALIBRATING THE LEVEL OF OXYGEN IN RESPIRATORY GAS RELATED TO THE LEVEL OF OXYGEN IN THE BLOOD CIRCULATION OF AN INDIVIDUAL

The present invention relates to a method for calibrating, or adjusting, the level of oxygen in respiratory gas related to the level of oxygen in the blood circulation of the individual, comprising providing a level of oxygen in the gas flow passing into, or out, of the respiratory system of the individual and producing a corresponding first output, providing a level of oxygen in the blood circulation of the individual and producing a corresponding second output, providing a computer for receiving and storing at least two measurements, each measurement being the concurrent output of said first output and said second output within a data structure, in which the two stored outputs are mutually related, in data storage means associated with the computer, the at least two measurements being conducted at respective levels of oxygen in the gas flow passing into the respiratory system, and calibrating the level of oxygen in the gas value in response to a delay between the level of oxygen in the blood circulation of the individual and the level of oxygen in the gas flow passing into, or out, of the respiratory system of the individual. 1. A method for calibrating the level of oxygen in respiratory gas related to the level of oxygen in the blood circulation of an individual , comprising:providing a level of oxygen in the gas flow passing into, or out, of the respiratory system of the individual and producing a corresponding first output,providing a level of oxygen in the blood circulation of the individual and producing a corresponding second output,providing a computer for receiving and storing at least two measurements, each measurement being the concurrent output of said first output and said second output within a data structure, in which the two stored outputs are mutually related, in a data storage means associated with the computer, the at least two measurements being conducted at respective levels of oxygen in the gas flow passing into the respiratory system, ...

GI-ENDOCRINE DRUG DELIVERY DEVICE AND METHOD OF USE

Shown are a device, system and method that improve the diabetes care of a patient that has undergone gastric surgery. The device provides continuously or intermediate monitoring at various intervals before and after meals of several sensors to perceive, among other things, the blood glucose level, EKG/heart rate and volume of meals a patient has consumed. Readings are sent to a control unit that receives input from at least one of: a meal sensor, glucose monitor, and EKG sensor to control a drug delivery unit that doses a prescribed agent at a specific quantity and time based on the readings to provide proper diabetes care for the patient. Components of the system such as the meal sensor glucose monitor, EKG sensor, control unit and drug delivery device may be implanted subcutaneously in the patient or outside the patient and may communicate with each other either wirelessly or may be directly wired together. 1. A gastric drug delivery device for improving diabetes patient care , comprising:a meal sensor apparatus having a base; the base defining a chamber;a pressure transducer disposed within the meal sensor apparatus, and the pressure transducer in fluid communication with the chamber;a gastric band bladder in fluid communication with the chamber, and wherein deflection of the band bladder causes a pressure differential in the chamber that is readable by the transducer.2. The gastric drug delivery device of claim 1 , further including a control unit that receives information from the transducer and determines a volume food consumed based on corresponding waveforms of the pressure differential read by the pressure transducer.3. The gastric drug delivery device of wherein the control unit further includes a memory to record at least one of a frequency of meals claim 2 , and a volume of meals.4. The gastric drug delivery device of wherein information from the transducer to the control unit is sent either by wireless connection or wire connection.5. The gastric drug ...

System for Providing Continuous Systolic Blood Pressure Measurement to Maintain Permissive Hypotension

A system for maintaining permissive hypotension in a patient includes monitoring of blood perfusion and pressure, combining blood perfusion and pressure data to determine systolic blood pressure, monitoring for detection of systolic blood pressure below a critical threshold value, and providing an alert to perfusion options to maintain permissive hypotension. The system may be adapted to adjust the critical threshold value for systolic blood pressure as treatment progresses. 1. A system for monitoring systolic blood pressure of a patient , comprising:a blood perfusion monitoring means;a pressure monitoring means;a means for combining blood perfusion data collected by the blood perfusion monitoring means and pressure data collected by the pressure monitoring means to determine systolic blood pressure, comparing the collected data to data stored in memory, and an alerting means for alerting a caregiver as to perfusion options to maintain permissive hypotension in the patient, based on the intermittent determination of current systolic blood pressure and by monitoring for detection of systolic blood pressure below a critical threshold value.2. The system of which is capable of finding current systolic blood pressure in addition to monitoring for a reduction in systolic blood pressure below a critical threshold followed by finding the new current systolic blood pressure as treatment ensues.3. The system of claim 1 , where the blood pressure monitoring components consists of a mechanically inflating cuff or mechanically induced pressure band around any part of an extremity capable of producing small incremental step wise increases or decreases in pressure around any part of an extremity.3. The system of where the perfusion monitoring component used in conjunction with the pressure producing component in is chosen among a pulse plethysmography sensor claim 1 , a piezoelectric sensor claim 1 , applanation tonometry claim 1 , Doppler signal claim 1 , light spectroscopy ...

Method and Apparatus for Measuring Glucose in Body Fluids Using Sub-Dermal Body Tissue Impedance Measurements

A method and an apparatus for measuring glucose level in the body fluid of a subject, typically blood glucose level, by measuring impedance of a body tissue, with two pairs of electrodes, two electrodes for injecting current into a body tissue and two electrodes for detecting the ensuing voltage of the body tissue. The body tissue is typically a sub-dermal or sub-cutaneous tissue. The measured impedance of the body tissue is used to correlate with directly determined glucose levels to determine the glucose level from the measured impedance. It is thus possible to determine body fluid glucose levels in a reliable and reproducible manner. 1. A method for measuring or monitoring blood glucose level in a subject , the method comprising:injecting an electrical current into a body tissue of the subject;detecting a voltage caused by the current flowing through the body tissue;measuring the impedance of the body tissue; and,calculating the blood glucose level in the subject as a function of the measured impedance.2. The method of claim 1 , wherein the electrical current is injected by a pair of injection electrodes.3. The method of claim 2 , wherein the voltage is detected by a pair of sensing electrodes.4. The method of claim 3 , wherein the injection electrodes and the sensing electrodes are inserted into the sub-dermal or subcutaneous body tissue of the subject.5. The method of claim 3 , wherein the sub-dermal body tissue is muscle claim 3 , fat or blood vessels.6. The method of claim 3 , wherein the injection electrodes and the sensing electrodes are in a 4-point arrangement.7. The method of claim 3 , wherein said electrical current is provided at a frequency of less than 10 MHz8. The method of claim 7 , wherein the electrical current is provided at a frequency of 1 MHz to 10 MHz.9. The method of claim 7 , wherein the electrical current is an alternating current.10. The method of claim 3 , wherein the blood glucose level is calculated by a microprocessor programmed to ...

INFUSION OF INSULIN INTO A PATIENT AND DIABETES MELLITUS MEDICAL METHODS BASED ON THE PATIENTS MONITORED ANALYTE CONCENTRATION

Medical data provided by a physiological parameter sensor is used for management of the patient's medical condition. Analytes that may be monitored and managed include, but are not limited to, acetyl choline, amylase, bilirubin, cholesterol, chorionic gonadotropin, creatine kinase (e.g., CK-MB), creatine, glucose, glutamine, growth hormones, hormones, ketones, lactate, oxygen, peroxide, prostate-specific antigen, prothrombin, thyroid stimulating hormone, and troponin. 1. A medical method of treating a patient having diabetes mellitus through the measurement of the patient's bodily fluids and the infusion of a medication into the patient in response thereto , the method comprising:applying blood of the patient to a test strip and inserting the test strip into a port of an insulin infusion pump;measuring a content of a blood analyte in the blood with the insulin infusion pump;measuring a content of an interstitial analyte with a sensor in communication with the insulin infusion pump;consulting with a physician to analyze the blood glucose concentration and the interstitial analyte concentration and outputting, from the insulin infusion pump, information relating to the blood glucose concentration and the interstitial analyte concentration directly to a printer;modifying a basal insulin delivery profile in the insulin infusion pump; andadministering insulin into the body of the patient in accordance with the modified basal insulin delivery profile.2. The medical method of treatment of claim 1 , wherein the blood analyte is selected from the group comprising: acetyl choline claim 1 , amylase claim 1 , bilirubin claim 1 , cholesterol claim 1 , chorionic gonadotropin claim 1 , creatine kinase (e.g. claim 1 , CK-MB) claim 1 , creatine claim 1 , glutamine claim 1 , growth hormones claim 1 , ketones claim 1 , lactate claim 1 , oxygen claim 1 , peroxide claim 1 , prostate-specific antigen claim 1 , prothrombin claim 1 , thyroid stimulating hormone claim 1 , and troponin.3. ...

INFUSION PUMP ASSEMBLY

An infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw. 1. An infusion pump device for delivering infusible fluid to a user , the device comprising:a reusable pump portion comprising a motor assembly;a disposable portion in removable relation to the reusable pump portion, the disposable portion comprising a plunger rod, the plunger rod connected to the plunger and extending away from the plunger to a distal end, the plunger rod having a threaded portion; andprocessing logic for executing one or more processes in the reusable pump portion,wherein when the disposable portion is attached to the reusable pump portion the plunger rod is engaged with the motor assembly, andwherein the plunger rod is displaceable by the motor assembly, andwherein the processing logic configured to monitor a displacement of the plunger rod to determine if the plunger rod was displaced an expected displacement in response to displacement by the motor assembly; andwherein if the plunger rod was not displaced the expected displacement, initiating an alarm sequence on the infusion pump device.2. The device in further comprising a battery assembly configured to power the ...

Methods And Devices For Central Photoplethysmographic Monitoring

Provided according to embodiments of the present invention are methods of monitoring individuals that include securing a photoplethysmography probe to at least one of a pre-auricular region and a post-auricular region of the individual and obtaining photoplethysmography signals from the photoplethysmography probe. Photoplethysmography probes and helmets related to such methods are also described herein. 1. A method of monitoring an individual comprisingsecuring a photoplethysmography probe to a post-auricular region of the individual;obtaining photoplethysmography signals from the photoplethysmography probe; andprocessing the photoplethysmography signals with a processing module.2. The method of claim 1 , wherein the processed photoplethysmography signals are analyzed to determine at least one of a blood flow and a blood oxygen saturation of the individual.3. The method of claim 1 , wherein the photoplethysmography probe is embedded into a helmet.4. The method of claim 1 , wherein processing the photoplethysmography signals comprises separating the photoplethysmography signals into an isolated AC component signal stream and an isolated DC component signal stream.5. The method of claim 4 , wherein at least one of the isolated AC component signal stream and the isolated DC component signal stream are analyzed to monitor the individual.6. The method of claim 1 , wherein the photoplethysmography probe is a reflectance probe.7. The method of claim 1 , wherein the photoplethysmography probe comprisesa wiring harness, and a probe base structure comprising an LED and a photodetector on the wiring harness,wherein the wiring harness is configured to secure around a user's ear and the probe base structure is at a proximal end of the wiring harness and configured to secure to a post-auricular region of the user.8. The method of claim 1 , wherein the photoplethysmography probe obtains photoplethysmography signals from the post-auricular artery. This application is a continuation ...

METHOD AND SYSTEM FOR PROVIDING AN INTEGRATED ANALYTE SENSOR INSERTION DEVICE AND DATA PROCESSING UNIT

Method and apparatus for providing an integrated analyte sensor and data processing unit assembly is provided. 118-. (canceled)19. An apparatus , comprising:an introducer including a lower portion having a sharp distal end configured for piercing through a skin layer;an analyte sensor; anda guard segment for the analyte sensor and the introducer.20. The apparatus of claim 19 , wherein the guard segment is configured to substantially cover the lower portion of the introducer and a lower portion of the analyte sensor.21. The apparatus of claim 20 , wherein the lower portion of the analyte sensor is disposed within the lower portion of the introducer.22. The apparatus of claim 19 , wherein the guard segment is configured to maintain the lower portion of the introducer and the analyte sensor in a substantially sterile environment.23. The apparatus of claim 19 , wherein the guard segment is configured to be removed from the lower portion of the introducer prior to placement of the sharp distal end and a portion of the analyte sensor through the skin layer.24. The apparatus of claim 19 , further comprising a data processing unit claim 19 , wherein the data processing unit includes an aperture through which the introducer and the analyte sensor pass.25. The apparatus of claim 24 , wherein the aperture comprises a self-sealing aperture.26. The apparatus of claim 24 , wherein the guard segment comprises a proximal end and a distal end claim 24 , wherein the proximal end of the guard segment is adjacent to a bottom surface of the data processing unit.27. The apparatus of claim 26 , wherein the distal end of the guard segment covers the sharp distal end of the introducer.28. The apparatus of claim 26 , further comprising an adhesive patch claim 26 , wherein the adhesive patch includes an opening through which the introducer and the analyte sensor pass.29. The apparatus of claim 28 , wherein the opening of the adhesive patch and the aperture of the data processing unit are ...

Advanced analyte sensor calibration and error detection

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

System and method for sleep disorders: screening, testing and management

The present invention provides a system and/or platform that can efficiently monitor/manage patients with sleep disorders. In one embodiment, the system and platform can train and/or certify (or help in training/certifying) service providers/professionals. In one embodiment, the system and platform is integrated with a software or an information system to manage data related to patients. In one embodiment, the system and platform utilizes home sleep test which is more convenient and acceptable. In one embodiment, the system/platform provides the information and knowledge related to a subject's conditions.

Method and apparatus for mitigating acute reoxygenation injury during percutaneous coronary intervention

A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes. The system combines a catheter-based sub-system which allows for simultaneous balloon dilation of a coronary artery and infusion of a carefully controlled perfusate during percutaneous coronary intervention. The system allows for modulation of levels of oxygen at the time of percutaneous intervention. In addition, catheters and systems are provided for administration of fluids with modified oxygen content during an intervention that incorporate upstream flow control members to compartmentalize the perfusion of the target coronary artery and the remainder of the heart.

Medical device having capacitive coupling communication and energy harvesting

Provided is a wearable, self-contained drug infusion or medical device capable of communicating with a host controller or other external devices via a personal area network (PAN). The medical device utilizes a PAN transceiver for communication with other devices in contact with a user's body, such as a physiological sensor or host controller, by propagating a current across the user's body via capacitive coupling. The wearable nature of the medical device and the low power requirements of the PAN communication system enable the medical device to utilize alternative energy harvesting techniques for powering the device. The medical device preferably utilizes thermal, kinetic and other energy harvesting techniques for capturing energy from the user and the environment during normal use of the medical device. A system power distribution unit is provided for managing the harvested energy and selectively supplying power to the medical device during system operation.

SYSTEM AND METHOD FOR CONFIGURING A RULE SET FOR MEDICAL EVENT MANAGEMENT AND RESPONSES

A system and method to configure a rule set used in connection with a medical monitoring system for monitoring patients and patient care equipment, especially medication delivery pumps, based on a variety of conditions and parameters associated with monitored biometric information and equipment information and for providing user-defined responses to those conditions and parameters. 1. A method for implementing a medical system algorithm by an authorized medical caregiver , the steps of the method comprising:providing a context free grammar to define the medical system algorithm, the grammar comprising non-terminal parameter symbols and terminal parameter symbols that are configured to be satisfied by a plurality of non-terminal medical system parameters and terminal medical system parameters, respectively, the grammar further comprising non-terminal condition symbols and terminal condition symbols that are configured to be satisfied by a plurality of nonterminal medical system conditions and terminal medical system conditions, respectively, the grammar further comprising a response symbol that is configured to be satisfied by a plurality of medical system responses;receiving a first parameter selection comprising at least of one of the non-terminal parameters or at least one of the terminal parameters, defined by the grammar;receiving a respective first medical system condition selection corresponding to the at least one of the non-terminal parameter symbol or terminal parameter symbol for the selected first parameter selection defined by the grammar;receiving a medical system response selection;generating the medical system algorithm from the first parameter selection, the first medical system condition selection, and the medical system response selection; andstoring the generated medical system algorithm for later use by an automated medical device.2. The method of wherein the first parameter selection comprises at least one of the non-terminal parameter symbols ...

Infusion Pump Apparatus, Method and System

An infusion pump system is disclosed. The infusion pump system includes an infusion pump and a controller device in wireless communication with the infusion pump, wherein the controller including instructions for controlling the infusion pump, wherein the instructions may be synchronized with a secure web portal. 1. An infusion pump system comprising:an infusion pump; anda controller device in wireless communication with the infusion pump,wherein the controller in communication with a secure web portal,wherein the secure web portal may contact the controller, andwherein if an acknowledgement of the secure web portal contact is not made on the controller the secure web portal contacts an emergency contact.2. The infusion pump system of wherein the controller device instructs the infusion pump claim 1 , and wherein the controller device synchronizes the instructions with the secure web portal.3. The infusion pump system of wherein the infusion pump and the controller device are paired using near field communication.4. The infusion pump system of further comprising a continuous glucose monitor system comprising a transmitter wherein the transmitter in wireless communication with the controller device.5. The infusion pump system of further comprising a blood glucose meter wherein the blood glucose meter in wireless communication with the controller device.6. The infusion pump system of further comprising wireless communication wherein the wireless communication is radio frequency communication.7. The infusion pump system of wherein the controller further comprising at least one accelerometer.8. A medical device system comprising:a first medical device; anda second medical device in wireless communication with the first medical device,wherein the controller in communication with the secure web portal,wherein the secure web portal may contact the controller, andwherein if an acknowledgement of the secure web portal contact is not made on the controller the secure web ...

ADAPTIVE SYSTEM FOR BLOOD FLUID REMOVAL

Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session. 1. A method carried out by a blood fluid removal system , comprising:storing a second data in a most effective to date data set; wherein the second data is data regarding system parameters employed in a first blood fluid removal session of a patient; and wherein a first data is data regarding the patient, the first data including one or more of a physiological parameter and time since last blood fluid removal session prior to the first blood fluid removal session of the patient; wherein at least one physiological parameter is measured in a dialysate;storing the second data in a least effective to date data set;determining whether at least one physiological parameter in a third data is closer to a target value than the first data; and replacing the data in the most effective to date data set with a fourth data if the third data is closer to the target value than the first data;wherein the third data is data regarding the patient, the data including one or more of a physiological parameter and time since last blood fluid removal session prior to a second blood fluid removal session of the patient; wherein at least one physiological parameter is measured in a dialysate; and wherein the fourth data is data regarding system parameters employed in the second blood fluid removal session of the patient;determining whether at least one physiological parameter in the third data is further from a target value than the first data; and replacing the data ...

Systems and methods for performing medical procedures involving accessing the lymphatic system

System and methods are provided for harvesting one or more organs, e.g., a lung from a donor body. In one embodiment, a distal end of a tubular member is introduced into the donor body's vasculature via a percutaneous access site, and the tubular member is manipulated until the distal end of the tubular member is disposed within the thoracic duct. Fluid is removed from the thoracic duct through the tubular member to a location exterior to the patient's body, and one or more organs are removed from the donor body. Optionally, one or more parameters within the thoracic duct or other parameters of the donor body may be monitored and fluid removal may be adjusted to reduce fluid accumulation within the one or more organs.

Systems and methods for optimization of plasma collection volumes

A plasmapheresis system and a method for operating a plasmapheresis system are provided by which the volume/weight of anticoagulated plasma that is collected is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume/weight of raw plasma within a plasma product having the maximum volume permitted by the FDA nomogram. In a plasmapheresis procedure having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the donor's increasing hematocrit, thus resulting in a greater total volume of plasma product to be collected during the plasmapheresis procedure.

Patch-Sized Fluid Delivery Systems and Methods

A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device. 1. A method for delivering an infusion medium to a user , the method comprising:providing a first housing portion and a second housing portion;providing the first housing portion and the second housing portion with connection structure to allow the first housing portion and the second housing portion to be selectively engaged with each other for operation and disengaged from each other to allow disposal of the first housing portion without disposing of the second housing portion;providing a pumping assembly;providing a first exit valve in the pumping assembly wherein the first exit valve inhibits fluid flow from a reservoir to a pump exit;providing a dispensing assembly downstream from the pumping assembly, and in fluid communication with the reservoir by a flow line;providing an exit assembly downstream from the dispensing assembly, the exit assembly in fluid communication with the pump exit: andmaintaining the infusion medium in the first housing portion so as to not contact the second housing portion.3. A method according to claim 1 , wherein the one-way valve comprises a duckbill valve structure.4. A method according to claim 1 , further comprising connecting ...

Infusion Unit

Improvements in an infusion unit are disclosed. The infusion unit is a portable pump that can be used with patient that have wrist access or decubital PICC/MID-LINES without the risk of line accidently getting pulled. The infusion unit is in the shape of a conveniently shell that has an appearance of an arm cast. There are no hoses that extend beyond the body of the infusion unit and any vein penetration is completely covered under the body of the infusion unit. The secure enclosed unit prevents unauthorized tampering and entry into the unit. The medication dosing can be remotely monitored, fusion resumed, changed by nursing and the patient. The infusion unit has a wireless connection to a network to adjust medication and monitor vital signs, namely heart rate, O2 level and blood pressure that can be monitored and recorded for review.

OPEN-LOOP INSULIN DELIVERY BASAL PARAMETERS BASED ON INSULIN DELIVERY RECORDS

Disclosed are techniques and a device operable to determine a total amount of insulin delivered to the user over a predetermined time period. The total amount of insulin includes a total basal dosage delivered in basal dosages and a total bolus dosage delivered in bolus dosages over the predetermined time period. A proportion of the total amount of insulin delivered to the user provided via the total basal dosage amount over the predetermined time period is calculated. In response determining the proportion of the total amount of insulin attributed to the total basal dosage amount of insulin exceeds a threshold, an average basal dosage to be delivered within a subsequent time period that is approximately equal to the threshold may be determined. An instruction may be generated and output to deliver a modified basal dosage that substantially maintains the average basal dosage over the subsequent time period. 1. A device , comprising:a processor operable to execute programming code and applications;a memory coupled to the processor and operable to store programming code, an artificial pancreas application and data; anda wireless communication device operable to wirelessly communicate with a paired device and communicatively coupled to the processor; determine a total amount of insulin delivered to a user over a predetermined time period, wherein the total amount of insulin is a sum of a total basal dosage amount of insulin delivered in basal dosages over the predetermined time period and a total bolus dosage amount of insulin delivered in bolus dosages over the predetermined time period;', 'determine a proportion of the total amount of insulin delivered to the user provided via the total basal dosage amount over the predetermined time period;', 'determine whether the proportion of the total amount of insulin attributed to the total basal dosage amount of insulin exceeds a threshold;', 'in response to determining the threshold is exceeded, determine an average basal ...

CLOSED-LOOP CONTROL BASED ON PREDICTED TRAJECTORIES

Disclosed herein are techniques for closed-loop control based on predicted trajectories. The techniques may involve predicting a trajectory of a glucose level of a patient based on past observations of the glucose level. The techniques may further involve determining a cost expression based on the predicted trajectory. The cost expression may be based on a duration of time that the trajectory is predicted to extend outside of a target glucose concentration range. Additionally, the techniques may involve affecting, based on the cost expression, at least one future command to at least one infusion pump so as to shorten the duration of time that the trajectory is predicted to extend outside of the target glucose concentration range. 1. A processor-implemented method comprising:predicting a trajectory of a glucose level of a patient based on past observations of the glucose level;determining a cost expression based on the predicted trajectory, wherein the cost expression is based on a duration of time that the trajectory is predicted to extend outside of a target glucose concentration range;affecting, based on the cost expression, at least one future command to at least one infusion pump so as to shorten the duration of time that the trajectory is predicted to extend outside of the target glucose concentration range.2. The method of claim 1 , wherein the at least one infusion pump comprises an insulin infusion pump.3. The method of claim 1 , wherein the at least one infusion pump comprises a glucagon infusion pump.4. The method of claim 1 , wherein the cost expression is defined to cover a set duration in the future.5. The method of claim 1 , wherein the predicting claim 1 , the determining claim 1 , and the affecting are performed on command intervals.6. A system comprising:one or more processors; and predicting a trajectory of a glucose level of a patient based on past observations of the glucose level;', 'determining a cost expression based on the predicted ...

INFUSION PUMP SYSTEM

Infusion pump system and associated methods The invention provides a fluid delivery system (), comprising: an outlet tube (); a pump () for pumping liquid along a fluid path () including the outlet tube; a closed sensing tube () branched from the fluid path which, in use, is filled with gas; and a sensor () configured to sense movement of a liquid front within the sensing tube and, responsive to sensing of said movement, determine that a partial or total occlusion has occurred within the outlet tube. 1. A fluid delivery system , comprising:an outlet tube;a pump for pumping liquid along a fluid path including the outlet tube;a closed sensing tube branched from the fluid path which, in use, is filled with gas; anda sensor configured to sense movement of a liquid front within the sensing tube and, responsive to sensing of said movement, determine that a partial or total occlusion has occurred within the outlet tube.2. The fluid delivery system according to claim 1 , wherein a bore of the sensing tube has a diameter such that only a single liquid front can exist within the sensing tube.3. The fluid delivery system according to claim 1 , further comprising a replaceable cartridge.4. The fluid delivery system according to claim 3 , wherein the replaceable cartridge further comprises a reservoir claim 3 , and wherein the pump is for pumping liquid from the reservoir along the fluid path.5. The fluid delivery system according to claim 3 , wherein the replaceable cartridge further comprises the sensing tube.6. The fluid delivery system according to claim 5 , wherein the replaceable cartridge comprises an optically transparent window allowing viewing of the sensing tube.7. The fluid delivery system according to claim 3 , wherein the sensor is located outside the replaceable cartridge.8. The fluid delivery system according to claim 1 , wherein the sensor is configured to transmit optical light towards the sensing tube claim 1 , and to detect light which is scattered off the ...

FIELD UPDATE OF AN AMBULATORY INFUSION PUMP SYSTEM

Portable or ambulatory infusion devices and systems capable of remotely updating an ambulatory fluid delivery device include safety protocols that verify the status of the ambulatory fluid delivery device before and after a field update of software. Methods of accomplishing the same field update of software are also described. 120-. (canceled)21. A method for remotely downloading software for operating an ambulatory infusion pump , the method comprising:receiving a notification that a software download is available for software for operating an ambulatory infusion pump from a source of the software downloadreceiving verification information from the source of the software download;verifying that a source of the software download is a qualified source based on the verification information;confirming a compatibility of the software download with the ambulatory infusion pump;receiving the software download from the qualified source; anddownloading the software for operating the ambulatory infusion pump only if the source of the software download is a qualified source and if the ambulatory infusion pump is compatible with the software download.22. The method of claim 21 , wherein receiving verification information from the source of the software download includes receiving a unique identifier for the source of the software download.23. The method of claim 22 , wherein the unique identifier for the source of the software download includes a password.24. The method of claim 22 , wherein the unique identifier for the source of the software download includes a certificate.25. The method of claim 21 , further comprising conducting one or more interactive verification tests prior to installing the software download.26. The method of claim 25 , wherein the one or more interactive verification tests include tests to verify proximity to the source of the software download claim 25 , the willingness of the user to initiate the software download claim 25 , or both.27. The method ...

Field update of an ambulatory infusion pump system

Portable or ambulatory infusion devices and systems capable of remotely updating an ambulatory fluid delivery device include safety protocols that verify the status of the ambulatory fluid delivery device before and after a field update of software. Methods of accomplishing the same field update of software are also described.

SENSOR FOR DETERMINING CONCENTRATION OF GAS

An optical sensor unit () for measuring a concentration of a gas is provided, comprising at least one sensing layer () adapted to be irradiated with a predetermined radiation; at least one gas-permeable layer () adjacent to one side of the at least one sensing layer () and adapted to pass gas which concentration is to be measured through the gas-permeable layer () towards the sensing layer (); a removable protective layer () covering at least the gas-permeable layer () and adapted to be removed before use of the optical sensor unit (), wherein the optical sensor unit () is adapted to measure an optical response of the at least one sensing layer (), which optical response depends on the concentration of the gas. 1. Optical sensor unit for measuring a concentration of a gas , comprising:at least one sensing layer adapted to be irradiated with a predetermined radiation;at least one gas-permeable layer adjacent to one side of the at least one sensing layer and adapted to pass gas which concentration is to be measured through the gas-permeable layer towards the sensing layer;a removable protective layer covering at least the gas-permeable layer and adapted to be removed before use of the optical sensor unit, wherein the optical sensor unit is adapted to measure an optical response of the at least one sensing layer, which optical response depends on the concentration of the gas.2. Optical sensor unit of claim 1 , further comprising a contact medium interposed at least between the gas-permeable layer and the removable protective layer claim 1 , the contact medium being a gel or a liquid claim 1 , wherein the contact medium is adapted to control the water content of the at least one gas-permeable layer and/or the at least one sensing layer.3. Optical sensor unit according to claim 1 , further comprising a second gas-permeable layer interposed between the contact medium and the removable protective layer.4. Optical sensor unit according to claim 1 , further comprising a ...

Digital Medical Intern System

Media, methods, and systems provide a platform for monitoring patient health and recommending treatment in a protocolized manner. The protocol is customizable to fit patient and physician needs and the platform is capable of alerting medical staff when treatment is needed, precluding traditional practices of intensive-monitoring. 120-. (canceled)21. A computer system including a non-transitory computer-readable medium having stored thereon instructions executable by a processing system to cause the processing system to perform functions to automatically manage bloodpressure and heartrate of a patient , the functions comprising:receiving heath data representing patient vital statistics acquired from the patient over time; from the patient vital statistics, automatically determining an epinephrine condition of the patient and automatically implement an epinephrine treatment action if the epinephrine condition is indicative of an epinephrine insufficiency;', 'if the epinephrine condition is not indicative of an epinephrine insufficiency, from the patient vital statistics, automatically determining a presence of a possible pulmonary embolism and automatically implement a pulmonary embolism treatment action if a possible pulmonary embolism is determined;', 'if a possible pulmonary embolism is not determined, from the patient vital statistics, automatically determining a metabolic acidosis condition and automatically implement a metabolic acidosis treatment action if metabolic acidosis is determined by the metabolic acidosis condition;', 'if metabolic acidosis is not determined by the metabolic acidosis condition, sequentially and automatically controlling delivery of drugs to the patient that are known to affect at least one of bloodpressure and heartrate; and', 'if, after controlling drugs delivered to the patient that are known to affect at least one of bloodpressure and heartrate, the one of bloodpressure or heartrate of the patient is not below the threshold, ...