23-03-2017 дата публикации
Номер: US20170079911A1
Принадлежит:
A pharmaceutical composition comprising bisacodyl [4,4′-(pyridine-2-ylmethylene)bis(4,1-phenylene) diacetate], a solvent, a buffer, and a polymer, methods and apparatus for delivery to a patient. 1. A liquid suppository , comprising:bisacodyl,acrylates/C10-30 alkyl acrylate cross-polymer,optionally, a solvent,optionally, a pH adjuster,optionally, a buffer,optionally, a preservative,optionally, a chelating agent, andoptionally, a wetting agent.2. A liquid suppository , consisting essentially of:bisacodyl,acrylates/C10-30 alkyl acrylate cross-polymer,optionally, a solvent,optionally, a pH adjuster,optionally, a buffer,optionally, a preservative,optionally, a chelating agent, andoptionally, a wetting agent.3. The liquid suppository of claim 1 , wherein the bisacodyl is present in an amount of 0.1-0.5% by weight.4. The liquid suppository of claim 1 , wherein the acrylates/C10-30 alkyl acrylate cross-polymer is present in an amount of 0.11-0.15% by weight.5. The liquid suppository of claim 1 , further comprising the solvent claim 1 ,wherein the solvent is present in an amount of 95-99% by weight, andthe solvent comprises at least one member selected from the group consisting of water and glycerin.6. The liquid suppository of claim 1 , further comprising the pH adjuster claim 1 ,wherein the pH adjuster is present in an amount of 0.02-0.05% by weight.7. The liquid suppository of claim 1 , further comprising the buffer claim 1 ,wherein the buffer is present in an amount of 0.01-0.04% by weight.8. The liquid suppository of claim 1 , further comprising the preservative claim 1 ,wherein the preservative is present in an amount of 0.01-0.4% by weight, andthe preservative comprises at least one member selected from the group consisting of methyl paraben and propyl paraben.9. The liquid suppository of claim 1 , further comprising the chelating agent claim 1 ,wherein the chelating agent is present in an amount of 0.02-0.08% by weight.10. The liquid suppository of claim 1 , further ...
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