ШПРИЦЫ С ОТВОДИМОЙ ИГЛОЙ

FIELD: medicine. SUBSTANCE: invention relates to medical equipment, specifically to syringes. Syringe can have a plunger body and a plunger seal, both independently in a sliding engagement inside the cylinder cavity for movement along a common longitudinal axis, and a needle fixed in the plunger body and extending through the plunger seal, needle has an inlet opening making a fluid connection with an internal needle canal; the cylinder has a reservoir for receiving a medical fluid; the reservoir extends between the plunger seal and the bottom; the bottom is closed with a partition. EFFECT: syringes with withdrawn needle are opened. 20 cl, 5 dwg, 1 tbl РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 722 312 C2 (51) МПК A61M 5/32 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A61M 5/32 (2020.02) (21)(22) Заявка: 2018126191, 15.12.2016 (24) Дата начала отсчета срока действия патента: Дата регистрации: 28.05.2020 15.12.2015 US 62/267,351 (43) Дата публикации заявки: 20.01.2020 Бюл. № 2 (45) Опубликовано: 28.05.2020 Бюл. № 16 (56) Список документов, цитированных в отчете о поиске: CA 2891102 A1, 26.06.2014. US 4031892 A, 28.06.1977. CA 2412409 A1, 20.05.2004. US 2008287881 A1, 20.11.2008. (85) Дата начала рассмотрения заявки PCT на национальной фазе: 16.07.2018 2 7 2 2 3 1 2 (73) Патентообладатель(и): ИИНДЖЕК ТЕКНОЛОДЖИЗ ИНК./ЛЕ ТЕКНОЛОЖИ ИИНДЖЕК ИНК. (CA) Приоритет(ы): (30) Конвенционный приоритет: R U 15.12.2016 (72) Автор(ы): МОЛСОН, Кэтрин Райзенбург (CA), ДЖЭКСОН, Джеймс (CA), ФИЛЛИПС, Скотт (CA), КАММИНГЗ, Тимоти (CA) CA 2016/051481 (15.12.2016) C 2 C 2 (86) Заявка PCT: (87) Публикация заявки PCT: R U 2 7 2 2 3 1 2 WO 2017/100926 (22.06.2017) Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, стр. 3, ООО "Юридическая фирма Городисский и Партнеры" (54) ШПРИЦЫ С ОТВОДИМОЙ ИГЛОЙ (57) Реферат: Изобретение относится к медицинской технике, а именно к шприцам. Шприц может иметь тело плунжера и уплотнение ...

ШПРИЦ ДЛЯ УДЕРЖИВАНИЯ ВАКУУМА В СОСТОЯНИИ ХРАНЕНИЯ

VERBESSERTE MEDIZINISCHE SPRITZEN

Auto-destruct, pre-loaded syringe

MODULE FOR A DEVICE FOR THE INJECTION OF DRUGS

MULTI-CHAMBER AMPUL FOR SPENDING A FROM SEVERAL SUBSTANCES OF EXISTING MIXTURE

PARENTERAL DRUG STORAGE DEVICE WITH CLOSURE PIERCING COUPLING MEMBER

DEVICE AND METHOD FOR STORING AND MIXING A BONE CEMENT

REAGENT PREPARATION AND DISPENSING DEVICE

A reagent preparation and dispensing device includes a body having a reaction chamber for a reagent and a solution reservoir for a solution. The solution reservoir is isolated from the reaction chamber. A plunger is movably coupled with the body. Movement of the plunger from a starting position to a seated position pushes the solution into the reaction chamber. A dispensing path extends from the reaction chamber out of the body. The dispensing path is configured to dispense a reagent mixture formed from the solution and the reagent. A vent path extends from the reaction chamber, the vent path vents reaction chamber gas displaced by the addition of the solution to the reaction chamber throughout movement of the plunger from the starting position to the seated position.

MULTIPLE DOSE VIAL AND METHOD

A vial for storing multiple doses of a substance to be dispensed into one or more syringes or other delivery devices. The vial has a body, a variable- volume storage chamber within the body for storing multiple doses of the substance therein, and a one-way valve connectable in fluid communication with a syringe or other delivery device. The one-way valve is moveable relative to the body between first and second positions (i) one of which permits the valve to open so that substance from the variable-volume storage chamber can flow therethrough and into the syringe or other delivery device connected in fluid communication therewith, and (ii) one of which prevents the valve from opening.

MEHRKAMMER-SPRITZAMPULLE.

Mischbehälter für die Aufnahme miteinander reaktionsfähiger Substanzen zur Herstellung gebrauchsfertiger Dentalpräparate

PROCEDURE FOR THE PRODUCTION A TO USE WITH A SUBKUTANNADEL CERTAIN ONE, WITH MEDICINES FILLED AMPUL.

Karpulenaufnahmevorrichtung for an administering apparatus and method for mounting a carpule in a Karpulenaufnahmevorrichtung.

Die Erfindung betrifft eine Karpulenaufnahmevorrichtung für ein Verabreichungsgerät mit einem ersten Gehäuse (1), einer länglichen Karpule (2) mit einem distalen und einem proximalen Ende, welche eine Längsachse und eine axiale Richtung definieren, einem Karpulenhalter (3) mit einem distalen und einem proximalen Ende (3b), wobei in dem Karpulenhalter (3) die Karpule (2) aufgenommen ist und der Karpulenhalter (3) zumindest teilweise in dem ersten Gehäuse (1) aufgenommen ist, einem elastischen Mittel, welches zwischen dem distalen Ende der Karpule und der Innenseite des distalen Endes des Karpulenhalters vorgesehen ist, einem Halteelement (5), welches proximal von dem proximalen Ende der Karpule angeordnet ist, wobei das Halteelement (5) zusammen mit der Karpule (2) relativ zu dem ersten Gehäuse (1) oder relativ zu dem Karpulenhalter (3) axial entlang der Längsachse der Karpule (2) in distaler Richtung zur Kompression des elastischen Mittels bis zu einer festlegbaren Position verschiebbar ...

SYRINGES WITH RETRACTABLE NEEDLE

LARGE CAPACITY SYRINGE

SYRINGE IN TWO COMPARTMENTS, TO THROW AFTER USE

TANK OF DRUG HAS PARENTERAL ADMINISTRATION

Improvements with the devices allowing to carry out or stop the communication between two enclosures

A mixing apparatus and method thereof

MULTI-CHAMBER SEQUENTIAL DOSE DISPENSING SYRINGE

A valve assembly is disclosed which partitions a syringe into proximal and distal chambers to provide a multi-chamber, sequentially dispensing syringe apparatus. The valve assembly has a valved stopper, an impact sensor which opens the valve upon impact between the valve assembly and internal distal end of the syringe and a gas separator which separates liquid from from gas disposed in the proximal chamber to assure gas is not delivered therefrom. The valve assembly is in fluid communicating with an associated syringe plunger and is displaced thereby. The valve assembly may be made from two parts. One part, a valved stopper, may be molded from rubber based material used in syringe plunger stoppers. The second part, the valve actuator, may be injection molded.

Parenteral apparatus

A unitary closure and delivery means for dispensing solutions for parenteral administration from containers having an open end with a constricted neck, comprising an outwardly directed portion extending from the constricted neck and an inwardly directed portion held in inwardly displaceable, sealable relation within said constricted neck. The outwardly directed portion is channeled with an axially directed bore. The inwardly directed portion has at least one axial bisecting division which extends to and communicates with the bore. The opposing surfaces of the division are normally separated, but when mated by compressive engagement of the divided parts while held within the neck form a liquid impermeable seal. When the unit is urged inwardly from the neck into the body of the container, the surfaces of the bisecting division separate to form a patent path of communication with the interior of the container and its contents.

ПРЕДВАРИТЕЛЬНО ЗАПОЛНЕННАЯ БОТУЛИНИЧЕСКИМ ТОКСИНОМ ШПРИЦЕВАЯ СИСТЕМА

Устройство для инъекции

VORGEFÜLLTE INJEKTIONSVORRICHTUNG FÜR EINMALVERWENDUNG

A pre-filled syringe including an oxygen absorber

Medicament delivery device

A medicament delivery device 100 for delivery of medicament through a cannula 132 from a cartridge 10. Device 100 comprises a first container 11 for storing a first substance, a second container 12 for storing a second substance and a valve for closing a distal end of the second container 12. Second container 12 is arranged coaxially with respect to the first container 11. A mixing element 304 is provided for causing displacement of the second substance into the first container 11 through the valve in a mixing stroke. A release element 202 is provided for holding the mixing element 304 in an initial position and is operable to release the mixing element 304 to initiate the mixing stroke. A needle shroud 400 is provided for shrouding the cannula, where removing the needle shroud 400 from the cannula 132 causes the release element 202 to operate. Mixing element 304 may comprise a stopper 56 driven by a mixing spring 302 in the mixing stroke. Release element 202 may be further moveable in ...

PARENTERAL DRUG STORAGE DEVICE WITH CLOSURE PIERCING COUPLING MEMBER

PLASTIC SYRINGE

VORGEFÜLLTE INJECTION DEVICE FOR A MARK USE

APPLIZIERVORRICHTUNG FOR A FLUID SUBSTANCE

A TWO-COMPARTMENT SYRINGE ASSEMBLY AND A METHOD OF PRODUCING A TWO-COMPARTMENT SYRINGE ASSEMBLY

PLASTIC SYRINGE

PLASTIC SYRINGE

Device and method for storing and mixing a bone cement

DEVICE AND METHOD FOR STORING AND MIXING A BONE CEMENT The invention relates to a device for mixing a polymethyl methacrylate bone cement formed of two starting components (1, 2) and for storing the starting components (1, 2) of the bone cement, said device having a tubular cartridge (3, 4) with a cylindrical interior, wherein a powder (1) is contained as first starting component in a front part of the interior of the cartridge (3, 4) and a container (9) containing a monomer liquid (2) as second starting component is arranged in a rear part of the interior of the cartridge (3, 4), wherein a discharge piston (6) is arranged between the container (9) and the powder (1), and wherein a conveying piston (5) is arranged on the side of the container (9) opposite the discharge piston (6), wherein the discharge piston (6) and the conveying piston (5) are arranged in the interior of the cartridge (3, 4) movably in the longitudinal direction, wherein a conduit means (22) is provided, which connects ...

Syringe for mixing two components and for retaining a vacuum in a storage condition

The present disclosure relates to a syringe for mixing two substances which have been retained separately inside the syringe, for instance in a storage condition.In particular the present disclosure relates to a syringe for 1) retaining a dry composition in a vacuum, and 2)mixing the dry composition with an aqueous medium to form a flowable substance. One embodiment relates to a syringe for retaining and mixing first and second substances comprising: a barrel comprising a sealable and/or closable distal outlet and a vacuum chamber for holding a first substance, a plunger incorporating a reservoir chamber for holding a second substance and configured to be axially displaced through a proximal end of the barrel, a membrane separating the vacuum chamber and the reservoir chamber, and a pointed member, such as one or more needles, for penetrating the membrane.

Pre-filled injection device with cartridge, having multiple chambers

An injection device (100) including a tubular body (3) within which a cartridge is inserted (10) equipped with a bottom (14) and a back chamber (8) containing one first substance (SI). The device (100) also has a front chamber (9) containing one second substance (S2) intended to be mixed inside the tubular body (3) with the first substance (SI) to reconstitute the injectable substance (S). The device (100) is characterized in that the cartridge (10) has a flexible body (13) suitable for tearing as a result of the increase of pressure inside the cartridge (10) in order to put in communication the back chamber (8) with the front chamber (9) and to allow the reconstitution of the injectable solution (S).

DISPOSABLE INJECTION DEVICE DESIGNED TO BE PRE-FILLED

L'invention concerne un dispositif d'injection comprenant un corps de seringue (1) délimitant une chambre destinée à être remplie de liquide, et un organe (25) de distribution du liquide comportant un embout d'obturation de ladite chambre prolongé d'une embase portant une aiguille d'injection protégée par un capuchon de protection (35), ledit organe de distribution étant mobile axialement entre une position d'obturation de la chambre et une position d'injection du liquide. Selon l'invention, l'organe de distribution (25) comprend un tronçon (31) intermédiaire entre l'embase et l'embout d'obturation, et le corps de seringue (1) comprend une bague (6) délimitant deux compartiments superposés (18,19) aptes à loger chacun ledit tronçon intermédiaire. De plus, le capuchon de protection (35) et ce tronçon intermédiaire (31) présentent des profils complémentaires (34,38) en forme de came aptes à permettre d'engendrer un déplacement axial de l'organe de distribution (25) vers sa position d'injection ...

SELF-ADMIXING DISPOSABLE HYPODERMIC NEEDLE

A self-admixing disposable hypodermic needle (admixing needle) includes a reservoir containing an additive, such as a buffering agent, to facilitate homogeneous mixing of the additive with an injection fluid, such as Lidocaine, contained in a cartridge held within a mechanically conjoined syringe. The admixing needle establishes a fluid communication pathway for hypodermically delivering the injection mixture to a patient preceding a potentially painful dental or medical procedure. Prior to removal, a delivery needle cap is pushed toward the syringe to dispense the additive into the cartridge. The delivery needle is then placed within the patient's tissues and the syringe is operated to force the injection mixture from the cartridge. Mixing surfaces on the male body (reservoir plunger) and the female body (reservoir) and other mechanical features homogeneously combine the injection fluid with the additive as the injection mixture travels through the admixing needle during the hypodermic ...

MEDICAMENT DELIVERY DEVICE AND METHODS FOR DELIVERING DRUGS TO INFANTS AND CHILDREN

A method of delivering epinephrine includes placing a distal end surface of a medical injector into contact with a target location of a patient. The medical injector includes a housing, an energy storage member, and a medicament container containing a dose of epinephrine effective for administration to the patient experiencing anaphylaxis and having a weight of less than 15 kg. The medicament container is coupled to a needle. The medical injector is actuated such that the energy storage member produces a force to move the needle from a first needle position to a second needle position. A distal tip of the needle extends from the distal end surface by a distance of between 7 millimeters and 8 millimeters when the needle is in the second needle position. A portion of the force is exerted to expel the dose of epinephrine when the needle is in the second position.

SURGICAL METHODS EMPLOYING PURIFIED AMPHIPHILIC PEPTIDE COMPOSITIONS

Compositions, methods and delivery devices (e.g., pre-filled syringes) for controlling bleeding during surgical procedures are provided, wherein the compositions are characterized as having an aqueous formulation that is capable of adopting a gelled state upon contact with bodily fluids and/or blood of a patient (i.e., physiological conditions).

INDICATOR

An auto-injector for delivering a liquid medicament comprises: a collapsible container for containing the liquid medicament(26); an openable closure; and an elongate indication member (21) located at least partially within the rigid outer container(22) and arranged to move longitudinally towards the distal end of the collapsible container when the openable closure is opened, in which longitudinal movement of the elongate indication member (21) produces visual, and/or audio and/or tactile feedback relating to injection progress to a user of the auto-injector.

PRELIMINARILY FILLED MUCH CHAMBER INJECTION DEVICE WITH CARTRIDGE

TANK OF DRUG HAS PARENTERAL ADMINISTRATION

Administration assembly for a medicament delivery device

本發明關於一種用於藥物輸送裝置的施用組合體。該施用組合體包含：修長管狀輸送構件遮蔽件(7)；匣保持器(11)，具有匣阻擋凸部(11b)，該匣阻擋凸部被建構用於防止藥物匣(31)朝近側運動，直到藥物匣受到朝近側的力為止；針組合體(13)，包括雙刃針，該雙刃針具有近側延伸針部(13a)和遠側延伸針部(13b)，其中該針組合體(13)被建構用於被組合於該匣保持器(11)，使得該遠側延伸針部(13b)延伸進入該匣保持器(11)；和施用機構，包括柱塞桿(27)，該柱塞桿被建構用於朝近側偏壓。其中該輸送構件遮蔽件(7)被建構用於相對於該匣保持器(11)朝遠側方向線性位移；且其中該輸送構件遮蔽件(7)被建構用於當該輸送構件遮蔽件朝該遠側方向運動時，啟動了該施用機構，造成該施用機構朝該近側方向運動該匣保持器(11)，且接下來以大於臨界值的力將該匣保持器(11)內側的該柱塞桿(27)朝該近側方向運動。

STORING AND MIXING RECEPTACLE

A storing and mixing receptacle including a container forming a first chamber at its lower end for initially storing a first ingredient, a first piston for separating the first chamber from a second chamber, a second piston movable in the second chamber and adapted to transfer a second ingredient from the latter chamber to the first chamber where the ingredients will be mixed. After removal of a closure means from the lower end of the container, the first piston will be actuated to expel the mixture from the receptacle in the form of a ready product such as a dental preparation ready for use.

SYSTEMS AND APPROACHES FOR STERILIZING A DRUG DELIVERY DEVICE

A drug delivery sterilization system includes a housing defining at least one receptacle, a container assembly having first and second ends, an elongated portion extending therebetween, and an electron beam or x-ray generator disposed near the housing. The container assembly includes a container having a container contact region at the second end and an inner volume to contain a medicament, a seal member having a seal member contact region to form a sealing interface with the container contact region, and a coupling device adapted to sealingly couple the seal member to the container. The container assembly is at least partially disposed in the receptacle such that the second end of the container is exposed through the housing. The electron beam or x-ray generator generates a sterilizing beam that penetrates the seal member to sterilize the sealing interface.

Dispenser for a liquid product

Es wird eine Appliziervorrichtung vorgeschlagen, umfassend einen Trägerkörper (12), der mit einer Applikationseinrichtung (14) versehen ist und der an der der Applikationseinrichtung (14) abgewandten Seite eine zylindrischen Zapfen (18) aufweist, der von einem Querkanal (26) durchgriffen ist, von dem ein Axialkanal (28) abzweigt, der zu der Applikationseinrichtung (14) führt, wobei auf dem zylindrischen Zapfen (18) eine Vorratseinrichtung (30) für eine fließfähige Substanz verschiebbar angeordnet ist. Die Vorratseinrichtung (30) hat eine ringförmige Dichtlippe (38), die an der Innenseite angeordnet ist und dichtend mit dem zylindrischen Zapfen (18) zusammenwirkt. Eine Aktivierung der Appliziervorrichtung erfolgt durch ein Verschieben der Vorratseinrichtung (30) auf dem zylindrischen Zapfen (18) in Richtung der Applikationseinrichtung (14). Die Vorratseinrichtung (30) weist einen zumindest bereichsweise elastisch verformbaren Aufnahmeabschnitt (34, 52, 62, 72, 82, 112) auf, so dass, wenn ...

CARTRIDGE FOR DISPENSING A MATERIAL

Patent RU2018103401A3

ВУ“? 2018103401`” АЗ Дата публикации: 11.09.2019 Форма № 18 ИЗ,ПМ-2011 Федеральная служба по интеллектуальной собственности Федеральное государственное бюджетное учреждение ж 5 «Федеральный институт промышленной собственности» (ФИПС) ОТЧЕТ О ПОИСКЕ 1. . ИДЕНТИФИКАЦИЯ ЗАЯВКИ Регистрационный номер Дата подачи 2018103401/14(004949) 30.06.2016 РСТ/ЕР2016/065260 30.06.2016 Приоритет установлен по дате: [ ] подачи заявки [ ] поступления дополнительных материалов от к ранее поданной заявке № [ ] приоритета по первоначальной заявке № из которой данная заявка выделена [ ] подачи первоначальной заявки № из которой данная заявка выделена [ ] подачи ранее поданной заявки № [Х] подачи первой(ых) заявки(ок) в государстве-участнике Парижской конвенции (31) Номер первой(ых) заявки(ок) (32) Дата подачи первой(ых) заявки(ок) (33) Код страны 1. 15175189.8 03.07.2015 ЕР* Название изобретения (полезной модели): [Х] - как заявлено; [ ] - уточненное (см. Примечания) ШПРИЦ ДЛЯ УДЕРЖИВАНИЯ ВАКУУМА В СОСТОЯНИИ ХРАНЕНИЯ Заявитель: ФЕРРОСАН МЕДИКАЛ ДИВАЙСИЗ А/С, ОК 2. ЕДИНСТВО ИЗОБРЕТЕНИЯ [Х] соблюдено [ ] не соблюдено. Пояснения: см. Примечания 3. ФОРМУЛА ИЗОБРЕТЕНИЯ: [Х] приняты во внимание все пункты (см. Примечания) [ ] приняты во внимание следующие пункты: [ ] принята во внимание измененная формула изобретения (см. Примечания) 4. КЛАССИФИКАЦИЯ ОБЪЕКТА ИЗОБРЕТЕНИЯ (ПОЛЕЗНОЙ МОДЕЛИ) (Указываются индексы МПК и индикатор текущей версии) А6б1М 5/20 (2006.01) 5. ОБЛАСТЬ ПОИСКА 5.1 Проверенный минимум документации РСТ (указывается индексами МПК) Аб1М 5/20 5.2 Другая проверенная документация в той мере, в какой она включена в поисковые подборки: 5.3 Электронные базы данных, использованные при поиске (название базы, и если, возможно, поисковые термины): СТРО, СМГРА, РЕРАТБЗ пес, РУУРТ, Е-ГлЬгагу, ЕАРАТБУ, Езрасепе, Соозе, }]-Р]а(Рав, РАТЕМТЗСОРЕ, Ра еагсй, КОРТО, ИЗРТО, Уапаех 6. ДОКУМЕНТЫ, ОТНОСЯЩИЕСЯ К ПРЕДМЕТУ ПОИСКА Кате- Наименование документа с указанием (где необходимо) частей, Относится к ...

Injection syringe

Syringe cartridge

Disclosed is a method for filling a cartridge which can be subsequently capped and closed. This is done by filling to a discrete level and then applying a closure. A displacement dome is provided at the lower portion of the syringe cartridge closure to first displace a predetermined amount of air or gas and then to displace a minor amount of fluid upon closure to seal the cartridge, and insure zero head space. The entirety of the process of filling is done in a vented environment, and the closure applied at ambient. The invention also provides an apparatus which includes a syringe cartridge having its open lower portion closed by a plunger piston. The upper portion is closed by a syringe cartridge closure having a leur tip cap. Means are optionally provided interiorly of the tip cap to retain a hollow needle, which is held in position by a leur tip, the latter being vented and provided with a seal for the needle. The piston plunger at the lower portion of the cartridge can be advanced, ...

Drug delivery apparatus

Indicator

VORGEFÜLLTE INJECTION DEVICE FOR A MARK USE

Mischbehälter for the admission of reacting with one another substances for the production of ready for use Dentalpräparaten in the form of paste

Dual compartment mixing and dispensing device

DUAL COMPARTMENT MIXING AND DISPENSING DEVICE

The present invention is directed to a dual compartment, mixing and dispensing device (10) suitable for the containment of two separate pharmaceutical components that mixable, upon breaking of a seal (18) that separates the compartments (11, 12), to provide an instantly mixed dose of medication. The medication can be administered to a patient through an aperture (15) located at one end of the device. The device is characterized as two compartments connected by a flexible, sealed orifice (18), wherein the two components are separated. Flexing of the device at the orifice breaks the seal (18a) and allows mixing of the components to prepare the dose. Thereafter, an end- portion of the device can be opened for oral administration of the dose.

MULTI-OUTLET MEDICAL DISPENSING DEVICE

SYSTEM AND METHOD FOR SAFETY SYRINGE

A system for serially injecting liquids includes a syringe body, proximal and distal stopper members disposed in the syringe body, a first liquid in a distal chamber, a second liquid in a proximal chamber, a plunger member, and a needle hub assembly coupled to a distal needle interface of the syringe body. The plunger member includes a needle retention feature disposed in a plunger interior, an energy-storage member disposed in the plunger interior, and an energy-storage member latching member disposed in the plunger interior. The needle assembly includes a needle having a needle proximal end feature, a hub, and a needle latching member configured to couple the needle to the hub. Manipulating the plunger member to insert the proximal stopper member distally relative to the syringe body initially expels the first liquid, then the second liquid. The needle is at least partially retractable into plunger interior.

SYRINGE FOR MIXING TWO COMPONENTS AND FOR RETAINING A VACUUM IN A STORAGE CONDITION

The present disclosure relates to a syringe for mixing two substances which have been retained separately inside the syringe, for instance in a storage condition.In particular the present disclosure relates to a syringe for 1) retaining a dry composition in a vacuum, and 2)mixing the dry composition with an aqueous medium to form a flowable substance. One embodiment relates to a syringe for retaining and mixing first and second substances comprising: a barrel comprising a sealable and/or closable distal outlet and a vacuum chamber for holding a first substance, a plunger incorporating a reservoir chamber for holding a second substance and configured to be axially displaced through a proximal end of the barrel, a membrane separating the vacuum chamber and the reservoir chamber, and a pointed member, such as one or more needles, for penetrating the membrane.

DEVICE AND METHOD FOR STORING AND MIXING A BONE CEMENT

The invention relates to a device for mixing a polymethyl methacrylate bone cement formed of two starting components (1, 2) and for storing the starting components (1, 2) of the bone cement, said device having a tubular cartridge (3, 4) with a cylindrical interior, wherein a powder (1) is contained as first starting component in a front part of the interior of the cartridge (3, 4) and a container (9) containing a monomer liquid (2) as second starting component is arranged in a rear part of the interior of the cartridge (3, 4), wherein a discharge piston (6) is arranged between the container (9) and the powder (1), and wherein a conveying piston (5) is arranged on the side of the container (9) opposite the discharge piston (6), wherein the discharge piston (6) and the conveying piston (5) are arranged in the interior of the cartridge (3, 4) movably in the longitudinal direction, wherein a conduit means (22) is provided, which connects the front part and the rear part of the interior of the ...

REAGENT PREPARATION AND DISPENSING DEVICE

... ²A reagent preparation and dispensing device includes a body having a reaction ²chamber for a reagent and a solution reservoir for a solution. The solution ²reservoir is isolated from the reaction chamber. A plunger is movably coupled ²with the body. Movement of the plunger from a starting position to a seated ²position pushes the solution into the reaction chamber. A dispensing path ²extends from the reaction chamber out of the body. The dispensing path is ²configured to dispense a reagent mixture formed from the solution and the ²reagent. A vent path extends from the reaction chamber, the vent path vents ²reaction chamber gas displaced by the addition of the solution to the reaction ²²chamber throughout movement of the plunger from the starting position to the ²seated position.² ...

DISPOSABLE INJECTION DEVICE DESIGNED TO BE PRE-FILLED

L'invention concerne un dispositif d'injection comprenant un corps de seringue (1, 13) délimitant une chambre destinée à être remplie d'un liquide, et un organe (17) de distribution du liquide comportant un embout (17a) d'obturation de la chambre prolongé d'un raccord conique mâle (17c) à verrouillage, et apte à se déplacer axialement entre une position d'obturation de ladite chambre et une position d'injection du liquide. Selon l'invention, l'organe de distribution (17) comprend un tronçon intermédiaire (20) ménagé entre l'embout d'obturation (17a) et le raccord conique mâle (17c). De plus, le corps de seringue (1, 13) comprend une bague (3), d'une part, délimitant deux compartiments superposés de formes conjuguées du tronçon intermédiaire (20) de l'organe de distribution (17), séparés par un col (9) apte à autoriser un déplacement axial dudit tronçon intermédiaire, et d'autre part, comportant un collier (12) s'étendant dans le prolongement du compartiment supérieur (8) de façon à loger ...

DUAL COMPARTMENT MIXING AND DISPENSING DEVICE

The present invention is directed to a dual compartment, mixing and dispensing device (10) suitable for the containment of two separate pharmaceutical components that mixable, upon breaking of a seal (18) that separates the compartments (11, 12), to provide an instantly mixed dose of medication. The medication can be administered to a patient through an aperture (15) located at one end of the device. The device is characterized as two compartments connected by a flexible, sealed orifice (18), wherein the two components are separated. Flexing of the device at the orifice breaks the seal (18a) and allows mixing of the components to prepare the dose. Thereafter, an end- portion of the device can be opened for oral administration of the dose.

PLASTIC SYRINGE

A prefilled disposable plastic syringe (1) comprising an open ended barrel (2) h aving a needle fitting (6) disposed at one end and being sealed at the other end by a moveable stopper (4) wherein said nee dle fitting end of the barrel (2) is sealed by a frangible closure (7) which is integral with the needle fitting (6), said closur e being adapted to co-operate with a hyperdermic needle support (21) shaped to fit onto said needle fitting (6) such that applica tion of a downward force on said hyperdermic needle support (21) onto said needle fitting (6) causes said closure (7) to separate fr om the needle fitting and move at least some way into the body of the syringe (1) and thereby reveal the contents of the syringe (1) f or injection.

Bulb improved for hypodermic injections

HYPODERMIC DEVICES

A pre-filled syringe including an oxygen absorber

BENEFICIAL AGENT DISPENSER

A dispensing device for use with a beneficial agent has a dispensing package, a dispenser disposed on an end portion of the dispensing package, and an actuator movably disposed along at least a portion of the package between a pre-dispensing state and a dispensing state. One arrangement also provides a beneficial agent dispenser having a dispensing port, an elongate portion and a plunger that is movably disposed relative to a tubular wall of the elongate portion during a dispensing stroke to partially penetrate a separable barrier and expel the beneficial agent through the dispensing port.

Applicator for applying a liquid to a location on a body

An applicator for administering a liquid to a selected location of a patient includes a main body having an interior cavity and a flexible outer wall. A frangible ampoule is configured to contain the liquid and configured to be positioned within the interior cavity of the main body. A hypodermic tube having a proximal end attached to the main body and a distal end. An applicator tip attached to the distal end of the hypodermic tube to dispense the liquid.

Multichamber ampoule for dispensing a mixture consisting of multiple substances

Mehrkammerampulle mit Verschluss- und Ausgabevorrichtung zum Aufbewahren mehrerer Substanzen und Ausgeben eines aus den mehreren Substanzen bestehenden Gemisches, aufweisend einen Mehrstopfenverschluss (140) mit mehreren Stopfen zum wahlweisen Verschliessen und Öffnen mehrerer Austrittsöffnungen der Mehrkammerampulle und einen Adapter (130) zum Mischen der Substanzen und Ausgeben des Gemisches, wobei der Mehrstopfenverschluss (140) und der Adapter (130) unter Ausbildung einer aus der Mehrkammerampulle herausnehmbaren Baueinheit drehbar miteinander verbunden sind.

PLASTIC SYRINGE

ШПРИЦЫ С ОТВОДИМОЙ ИГЛОЙ

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2018 126 191 A (51) МПК A61M 5/32 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2018126191, 15.12.2016 (71) Заявитель(и): ИИНДЖЕК ТЕКНОЛОДЖИЗ ИНК./ЛЕ ТЕКНОЛОЖИ ИИНДЖЕК ИНК. (CA) Приоритет(ы): (30) Конвенционный приоритет: 15.12.2015 US 62/267,351 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 16.07.2018 R U (43) Дата публикации заявки: 20.01.2020 Бюл. № 2 (72) Автор(ы): МОЛСОН, Кэтрин Райзенбург (CA), ДЖЭКСОН, Джеймс (CA), ФИЛЛИПС, Скотт (CA), КАММИНГЗ, Тимоти (CA) (86) Заявка PCT: (87) Публикация заявки PCT: WO 2017/100926 (22.06.2017) A Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, стр. 3, ООО "Юридическая фирма Городисский и Партнеры" R U (57) Формула изобретения 1. Шприц, имеющий тело плунжера и уплотнение плунжера, оба независимо в скользящем зацеплении внутри полости цилиндра для движения вдоль общей продольной оси, и иглу, закрепленную в теле плунжера и проходящую через уплотнение плунжера, игла имеет впускное отверстие, позволяющее сообщение по текучей среде с внутренним каналом иглы, цилиндр имеющий резервуар для приема медицинской текучей среды, причем резервуар проходит между уплотнением плунжера и дном, дно закрыто перегородкой, причем для выполнения инъекции, тело плунжера перемещается с возможностью скольжения вдоль зазора проникновения в направлении уплотнения плунжера, во время этого движения игла прокалывает перегородку и выступает из дна, без выполнения инъекции медицинской текучей среды, до тех пор, пока тело плунжера не войдет в зацепление с уплотнением плунжера, после чего тело плунжера и уплотнение плунжера совместно перемещают для того, чтобы выполнить инъекцию медицинской текучей среды, пока уплотнение плунжера не достигнет дна. 2. Шприц по п. 1, в котором впускное отверстие иглы представляет собой латеральное отверстие, причем латеральное отверстие становится открытым для медицинской текучей среды в резервуаре, ...

ПУЗЫРЕК ДЛЯ МНОЖЕСТВА ДОЗ И СПОСОБ

... 1. Удхмдв ввоибшидпу сккхвкдхвнмдв иок ссвсптссшидпуипмпивпиизп ппчнв иоп ппчнвпэ вппокзоеоивикхнпчк аввпокоивикхпчквшидпу сснсвсптс2. Уп п 1, вкоквсвпсплптввпспн ишидпу чн вкх3. Упп. 1, вккхскхпо4. У п п 1, в к окввсээк овнсзск кпспптвчн кпднкмдок пэпвптвчн кпднккпдок5. Уп п 4, вкокввсск пэээкввксскифскмн6. Уп п 5, вкв пмм ои (i) ээкопутсвновоквоски(ii) скопушидвновоквоск7. Уп п 1, вкокввсэкиск пээкяпоск кпднокпдок8. Уп п 1, вкуввспипуу кяппи нииэ д н к х вв пэвсвпудгипврпову9. Уп п 8, вкпипууяпуп пмм оижгипннииэ10. Уп п 1, дсс рнпповоок пэсвсвпкншидпу11. Уп п 10, вксясЛ12. Уп п 1, вкоксвновпкпп13. Уп п 12, дввсп ксоквновпкпп14. Уп п 13, вкпикф15. Уп п 1, вк (i) вппокввкспу чпспокопвоп пэ(ii) ввп окрспуд пвпквоп16. Уп п 15, вкокввсскиэквксск чозп пээкяпоск кпднокпдок пвпппупсппэкоск аввпэкрспдпвпэкоск17. Уп п 16, вкпувксэкппсквэк18. Уп п 16, дсс рнпповоок пэсвсвпкшидпу пэпшидпувкпвноппквп19. Уп п 18, вксопу ввксэквпп20. У п п 18, в к ск ст чпссушидпуввксскипквноппквп21. Уп п 18, вксясЛ22 ...

An improved syringe

LARGE CAPACITY SYRINGE

... 1437595 Injection syringe SURVIVAL TECHNOLOGY INC 29 May 1974 [27 Sept 1973] 23742/74 Heading A5R A combination cartridge and cannula unit comprises a cylindrical cartridge body 30 having a rear open end and a necked portion 31 at the forward end nearest a cannula (87), a chamber for medicament 110 between a plunger 40 slidably carried in body 30 and a stopper 90 mounted in portion 31, a cap 70, fitting over a ring 96 and secured to a flange 34 of portion 31, said cap having a cylindrical sleeve extending forwardly and coaxial with the axis of body 30, a cylindrical needle support 100 extending from the rearward side of a cannula mounting member 83 and slidably fitting within sleeve 76, a needle 102 fixed to the rearward end of support 100 which support has an annular recess 106 engaging an annular head 78 on cap 70 to space the needle from the stopper, the cannula (87) having a hub (88) with an outer sleeve 85 of a cannula hub mounting portion and a cannula sheath 120 to maintain the sterility ...

Drug delivery device with sterile fluid flowpath and related method of assembly

Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing and a container disposed therein. The container may include a reservoir containing a drug and a movable stopper. A first seal member may be connected to the container at a distal end of the reservoir. A first removable membrane may cover an exterior surface of the first seal member to maintain sterility of that surface prior to operation of the device. A fluid pathway assembly may be configured to establish fluid communication with the reservoir during operation of the device. A second seal member may be connected to a first end of the fluid pathway assembly. A second removable membrane may cover an exterior surface of the second seal member to maintain sterility of that surface prior to operation of the device.

Syringe assembly, cap, and puncture needle

A syringe assembly (10) is provided with the following: an outer cylinder (12) having a cylinder tip (20); a puncture needle (14) that protrudes from the cylinder tip (20); and a cap (16) that seals the tip of a needle hole (28), the cap being detachably attached to the outer cylinder (12). The cap (16) has a storage opening (38) that stores the puncture needle (14), a bottom wall (36) into which the puncture needle (14) penetrates, and a stopper (48) that defines the depth to which the puncture needle (14) penetrates the bottom wall (36). With the cap (16) being attached to the outer cylinder (12), a length (L1) measured from the farthest base end position of the contact region between the cap (16) and the puncture needle (14), to the farthest base end position of an edge face (30), is 1-3 mm.

Auto-injector with indicator

An auto-injector for delivering a liquid medicament comprises: a collapsible container for containing the liquid medicament(26); an openable closure; and an elongate indication member (21) located at least partially within the rigid outer container(22) and arranged to move longitudinally towards the distal end of the collapsible container when the openable closure is opened, in which longitudinal movement of the elongate indication member (21) produces visual, and/or audio and/or tactile feedback relating to injection progress to a user of the auto-injector.

Multi-chamber sequential dose dispensing syringe

A valve assembly is disclosed which partitions a syringe into proximal and distal chambers to provide a multi-chamber, sequentially dispensing syringe apparatus. The valve assembly has a valved stopper, an impact sensor which opens the valve upon impact between the valve assembly and internal distal end of the syringe and a gas separator which separates liquid from from gas disposed in the proximal chamber to assure gas is not delivered therefrom. The valve assembly is in fluid communicating with an associated syringe plunger and is displaced thereby. The valve assembly may be made from two parts. One part, a valved stopper, may be molded from rubber based material used in syringe plunger stoppers. The second part, the valve actuator, may be injection molded.

A pre-filled syringe including an oxygen absorber

The invention provides a syringe or autoinjector for dispensing a drug comprising a rigid syringe body containing the drug, an oxygen absorbing material, a separating element between the drug and oxygen absorbing material to prevent the drug from contacting the oxygen absorbing material but which allows oxygen to pass from the drug to the oxygen absorbing material, and an oxygen impermeable container enclosing both the drug and the oxygen absorbing material, wherein the oxygen impermeable container partially or fully forms the rigid syringe body or is held within the rigid syringe body.

Surgical methods employing purified amphiphilic peptide compositions

Compositions, methods and delivery devices (e.g., pre-filled syringes) for controlling bleeding during surgical procedures are provided, wherein the compositions are characterized as having an aqueous formulation that is capable of adopting a gelled state upon contact with bodily fluids and/or blood of a patient (i.e., physiological conditions).

Syringe for mixing two components and for retaining a vacuum in a storage condition

The present disclosure relates to a syringe for mixing two substances which have been retained separately inside the syringe, for instance in a storage condition.In particular the present disclosure relates to a syringe for 1) retaining a dry composition in a vacuum, and 2)mixing the dry composition with an aqueous medium to form a flowable substance. One embodiment relates to a syringe for retaining and mixing first and second substances comprising: a barrel comprising a sealable and/or closable distal outlet and a vacuum chamber for holding a first substance, a plunger incorporating a reservoir chamber for holding a second substance and configured to be axially displaced through a proximal end of the barrel, a membrane separating the vacuum chamber and the reservoir chamber, and a pointed member, such as one or more needles, for penetrating the membrane.

MULTI-CHAMBER SEQUENTIAL DOSE DISPENSING SYRINGE

STORING AND MIXING RECEPTACLE

BONE CEMENT APPLICATOR WITH CLOSURE SYSTEM DRIVEN BY BONE CEMENT DOUGH

The invention relates to a bone cement applicator for mixing and applying a bone cement, with which the starting components (1, 2) of the bone cement is mixable in a closed cartridge (3, 4) to form a bone cement dough (44), wherein the cartridge (3, 4) has a multi-part closure system comprising a discharge opening, wherein at least two parts (7, 8) of the closure system are movable relative to one another, driven by a movement of the mixed bone cement dough (44), and the discharge opening is opened the movement of the at least two parts (7, 8) of the closure system relative to one another, and wherein the movement of the mixed bone cement dough (44) is drivable by a pressure on the bone cement dough (44). The invention also relates to methods for mixing the starting components (1, 2).

BONE CEMENT APPLICATOR WITH CLOSURE SYSTEM DRIVEN BY BONE CEMENT DOUGH

The invention relates to a bone cement applicator for mixing and applying a bone cement, with which the starting components (1, 2) of the bone cement is mixable in a closed cartridge (3, 4) to form a bone cement dough (44), wherein the cartridge (3, 4) has a multi-part closure system comprising a discharge opening, wherein at least two parts (7, 8) of the closure system are movable relative to one another, driven by a movement of the mixed bone cement dough (44), and the discharge opening is opened the movement of the at least two parts (7, 8) of the closure system relative to one another, and wherein the movement of the mixed bone cement dough (44) is drivable by a pressure on the bone cement dough (44). The invention also relates to methods for mixing the starting components (1, 2).

LARGE CAPACITY SYRINGE

REAGENT PREPARATION AND DISPENSING DEVICE

A reagent preparation and dispensing device includes a body having a reaction chamber for a reagent and a solution reservoir for a solution. The solution reservoir is isolated from the reaction chamber. A plunger is movably coupled with the body. Movement of the plunger from a starting position to a seated position pushes the solution into the reaction chamber. A dispensing path extends from the reaction chamber out of the body. The dispensing path is configured to dispense a reagent mixture formed from the solution and the reagent. A vent path extends from the reaction chamber, the vent path vents reaction chamber gas displaced by the addition of the solution to the reaction chamber throughout movement of the plunger from the starting position to the seated position.

PLASTIC SYRINGE

SET OF SYRINGE WITH CLOSING VALVE

Conjunto de jeringa que comprende un cilindro con una porcion exterior que incluye un pasaje de salida, un émbolo instalado de modo deslizable en el cilindro y un dispositivo de válvula para controlar la transferencia de material a través del pasaje de salida, incluyendo el dispositivo de válvula una porcion de válvula movil a lo largo del cilindro entre una primera porcion dentro del pasaje de salida que bloquea la transferencia de material por él y una segunda posicion que admite la transferencia de material a través del pasaje de salida; y un dispositivo de accionamiento de válvula instalado en el cilindro para el movimiento relativo a una posicion neutral a fin de desplazar la porcion de válvula entre las posiciones primera y segunda.

SURGICAL METHODS EMPLOYING PURIFIED AMPHIPHILIC PEPTIDE COMPOSITIONS

SURGICAL METHODS EMPLOYING PURIFIED AMPHIPHILIC PEPTIDE COMPOSITIONS Compositions, methods and delivery devices (e.g., pre-filled syringes) for controlling bleeding during surgical procedures are provided, wherein the compositions are characterized as having an aqueous formulation that is capable of adopting a gelled state upon contact with bodily fluids and/or blood of a patient (i.e., physiological conditions). [No Figure] ...

Drug delivery device with retaining member

A drug delivery device is provided for delivering a drug to a target tissue site. The drug delivery device comprises a body comprising a proximal end and a distal end and a chamber disposed therebetween. An upper portion is disposed about the proximal end of the body. A retaining member is disposed within a wall of the body and engageable with the chamber and a plunger is configured for disposal within the upper portion and the chamber. The upper portion is movable about the proximal end of the body to open the chamber such that the plunger is disposed within a passageway defined within the chamber, and movement of the plunger in a distal direction pushes the retaining member such that the drug moves out of the body. Methods are also disclosed.

Container for lyophilic biologically active substances

PREFILLED SYRINGE

The prefilled syringe according to the present disclosure includes: a liquid medicine; a barrel including a cylindrical barrel body section that contains the liquid medicine, and a nozzle section that is provided on a distal end side of the barrel body section and configured to discharge the liquid medicine, the barrel being provided with a proximal end opening on a proximal end section of the barrel body section; a cap configured to seal a distal end opening provided on a distal end section of the nozzle section; a gasket configured to slide on an inner circumferential surface of the barrel body section; a syringe plunger configured to be mounted to the gasket and has an insertion section that can be inserted into the barrel body section; and an RFID tag mounted on the insertion section and including an antenna for communication and a memory. 1. A prefilled syringe comprising:a liquid medicine;a barrel including a barrel body section that is cylindrical and that contains the liquid medicine, and a nozzle section that is provided on a distal end side of the barrel body section and configured to discharge the liquid medicine, the barrel being provided with a proximal end opening on a proximal end section of the barrel body section;a cap configured to seal a distal end opening provided on a distal end section of the nozzle section;a gasket configured to slide on an inner circumferential surface of the barrel body section;a syringe plunger configured to be attached to the gasket and has an insertion section insertable into the barrel body section; andan RFID tag attached on the insertion section of the syringe plunger, the RFID tag including an antenna for communication and a memory.2. The prefilled syringe according to claim 1 ,wherein the syringe plunger includes a mounting member mountable to the gasket, and a pressing member mountable to the mounting member; andthe insertion section is provided on the mounting member.3. The prefilled syringe according to claim 2 , ...

SURGICAL METHODS EMPLOYING PURIFIED AMPHIPHILIC PEPTIDE COMPOSITIONS

Compositions, methods and delivery devices (e.g., pre-filled syringes) for controlling bleeding during surgical procedures are provided, wherein the compositions are characterized as having an aqueous formulation that is capable of adopting a gelled state upon contact with bodily fluids and/or blood of a patient (i.e., physiological conditions).

TWO-COMPONENT-MIXING PREFILLED SYRINGE KIT

In a two-component-mixing prefilled syringe kit for preparing an injection solution by mixing a drug component in a syringe barrel and a liquid component in a container, when the injection needle pierced on the seal member of the container outlet is pulled out after preparation of the injection solution, a leak to the outside of the remaining liquid in the container is effectively prevented. 1. A two-component-mixing prefilled syringe kit , comprising;a syringe barrel in which an injection needle is attached to one end, a plunger is slidably inserted from an opening of the other end, and a solid component or a liquid component constituting an injection solution is filled inside;a container in which an outlet is sealed with a seal member that can be pierced by the injection needle, and a liquid component constituting the injection solution is filled inside;a holding member for holding at least one of the syringe barrel or the container so as to be movable along the barrel axis direction of the syringe barrel with the tip of the injection needle facing the outlet of the container;wherein, it is characterized that a space-forming body which forms a space facing the surface of the seal member with a space sealed from the outside is arranged so as to be in close contact with the surface of the seal member, and the space-forming body is formed of a material which can be pierced by the injection needle at a portion facing the tip of the injection needle along the barrel axis direction of the syringe barrel.2. The two-component-mixing prefilled syringe kit as defined in claim 1 , wherein;a volume of a space surrounded by the surface of the seal member and the space-forming body is in the range of 0.001 ml to 0.03 ml.3. The two-component-mixing prefilled syringe kit as defined in claim 1 , further comprising:a needle cap which is formed of a material that can be pierced by the injection needle to cover the injection needle from the tip side, and fixed at base end side to a ...

MEDICAMENT DELIVERY DEVICE AND METHODS FOR DELIVERING DRUGS TO INFANTS AND CHILDREN

A method of delivering epinephrine includes placing a distal end surface of a medical injector into contact with a target location of a patient. The medical injector includes a housing, an energy storage member, and a medicament container containing a dose of epinephrine effective for administration to the patient experiencing anaphylaxis and having a weight of less than 15 kg. The medicament container is coupled to a needle. The medical injector is actuated such that the energy storage member produces a force to move the needle from a first needle position to a second needle position. A distal tip of the needle extends from the distal end surface by a distance of between 7 millimeters and 8 millimeters when the needle is in the second needle position. A portion of the force is exerted to expel the dose of epinephrine when the needle is in the second position. 1. A method , comprising:placing a distal end surface of a medical injector into contact with a target location of a patient, the medical injector including a housing, an energy storage member and a medicament container containing a dose of epinephrine effective for administration to the patient experiencing anaphylaxis and having a weight of less than 15 kg, the medicament container coupled to a needle; andactuating the medical injector after the placing such that the energy storage member produces a force to move the needle from a first needle position to a second needle position, a distal tip of the needle extending from the distal end surface by a distance of between 7 millimeters and 8 millimeters when the needle is in the second needle position, a portion of the force exerted to expel the dose of epinephrine from the medicament container when the needle is in the second position.2. The method of claim 1 , wherein the dose of epinephrine contains between about 0.06 mg epinephrine and about 0.150 mg epinephrine.3. The method of claim 1 , wherein the dose of epinephrine contains about 0.1 mg epinephrine.4. ...

Multiple Dose Vial and Method

A vial for storing multiple doses of a substance to be dispensed into one or more syringes or other delivery devices. The vial has a body, a storage chamber within the body for storing multiple doses of the substance therein, a sterile filter configured to sterilize air or other gas flowing into the storage chamber through the filter, and a one-way valve connectable in fluid communication with a syringe or other delivery device. The one-way valve is moveable relative to the body between first and second positions (i) one of which permits the valve to open so that substance from the storage chamber can flow therethrough and into the syringe or other delivery device connected in fluid communication therewith, and (ii) one of which prevents the valve from opening.

SYSTEMS AND METHODS FOR SUBMUCOSAL TISSUE SEPARATION

The present disclosure relates to the field of medical devices generally and specifically, to endoscopic systems and methods for resection of malignant and pre-malignant lesions within the gastrointestinal (GI) tract. In particular, the present disclosure relates to systems and methods for delivering injectable compositions between tissue layers (e.g., between the muscularis and submucosa layers) to elevate and stabilize the lesion for fast and efficient resection. 1. A system , comprising:a delivery device comprising a proximal portion, distal portion and lumen extending therebetween;a first injectable composition disposed within the distal portion of the delivery device; anda second injectable composition disposed within the proximal portion of the delivery device;wherein a viscosity of the first injectable composition is less than a viscosity of the second injectable composition;wherein the first and second injectable compositions are separated by a barrier member; andwherein the system is configured to sequentially deliver the first and second injectable compositions.2. The system of claim 1 , wherein the barrier member is configured to rupture above a threshold level of force.3. The system of claim 1 , wherein the barrier member includes a biocompatible or biodegradable material.4. The system of claim 1 , wherein the second injectable composition comprises a hydrophilic polymer selected from the group consisting of acrylate-based polymers claim 1 , polyurethane-based polymers claim 1 , polynorbornene-based polymer and polylactide-based polymers.5. The system of claim 4 , wherein the hydrophilic polymer further comprises a polysaccharide.6. The system of claim 5 , wherein the polysaccharide is a xanthan gum.7. The system of claim 1 , wherein the delivery device includes a sharpened distal end.8. The system of claim 1 , wherein the delivery device is configured to be delivered through a working channel of an endoscope.9. A system claim 1 , comprising:a delivery ...

SYSTEMS AND APPROACHES FOR STERILIZING A DRUG DELIVERY DEVICE

An on-body injector system includes a drug container assembly including a container, a seal member, and a sealing interface between the seal member and the container. The container includes an opening and the seal member at least partially covers the opening in the container. A fluid pathway assembly is coupled to the drug container assembly and includes a needle that is movable between a storage position, in which a point of the needle is spaced from the seal member, and a delivery position, in which the point of the needle is disposed at least partially through the seal member. A radiation generator is configured to emit rays of radiation to sterilize and/or disinfect the sealing interface. A barrier is disposed adjacent to the sealing interface and has an opening. At least a portion of the drug container assembly is positioned adjacent to the opening in the barrier. 1. An on-body injector system comprising:a drug container assembly including a container, a seal member, and a sealing interface between the seal member and the container, the container having an opening and the seal member at least partially covering the opening in the container;a fluid pathway assembly coupled to the drug container assembly and including a needle, the needle being movable between a storage position, in which a point of the needle is spaced from the seal member, and a delivery position, in which the point of the needle is disposed at least partially through the seal member;a radiation generator configured to emit rays of radiation to sterilize and/or disinfect the sealing interface;a barrier disposed adjacent to the sealing interface and having an opening; andwherein at least a portion of the drug container assembly is positioned adjacent to the opening in the barrier.2. The on-body injector system of claim 1 , wherein the barrier includes a wall and the opening is formed in the wall.3. The on-body injector system of claim 2 , wherein at least a portion of the container and the ...

Mixing apparatus and method thereof

An apparatus for mixing a fluid material and a solid material comprises (a) a barrel; (b) a plunger displaceable within the barrel; (c) a slider disposed within the barrel between the fluid and solid materials. The slider, when reciprocatively displaced within the barrel, is permeable by the fluid material and the solved solid material under a pressure differential between the fluid and solid materials. The pressure differential is multiply exerted to the slider by the plunger such that a homogeneous mixture is obtained.

BENEFICIAL AGENT DISPENSER

A dispensing device for use with a beneficial agent has a dispensing package, a dispenser disposed on an end portion of the dispensing package, and an actuator movably disposed along at least a portion of the package between a pre-dispensing state and a dispensing state. One arrangement also provides a beneficial agent dispenser having a dispensing port, an elongate portion and a plunger that is movably disposed relative to a tubular wall of the elongate portion during a dispensing stroke to partially penetrate a separable barrier and expel the beneficial agent through the dispensing port. 1. A dispensing device for delivering a beneficial agent comprising:an elongated frame comprising two walls substantially parallel to each other comprising tracks;a dispensing package at least partially disposed in the elongated frame, comprising a flexible wall, and containing the beneficial agent;a fluid transport device communicable with the dispensing package;{'claim-text': ['a proximal end comprising a follower configured to guide the proximal end in the tracks; and', 'a distal end configured to operate the actuation stem along the elongated frame; and'], '#text': 'an actuation stem moveably disposed in the elongated frame comprising:'}wherein when the actuation stem is advanced into the elongated frame, the follower moves in the track causing the proximal end to compress the dispensing package, collapsing the flexible wall, and expelling the beneficial agent through the fluid transport device.2. A dispensing device according to claim 1 , wherein the actuation stem further comprises a roller disposed at the proximal end.3. A dispensing device according to claim 1 , wherein the flexible wall of the dispensing package is tubular.4. A dispensing device according to claim 1 , wherein the flexible wall of the dispensing package comprises a first wall and a second wall claim 1 , wherein at least the first wall is preformed to create a cavity for containing the beneficial agent ...

Systems and approaches for sterilizing a drug delivery device

A shielding member for use in sterilizing drug container assemblies includes a housing. The housing includes a first shielding portion and a second shielding portion. The first shielding portion includes a first and second surfaces and a plurality of first bore portions extending between. The second shielding portion having a first and second surfaces and a plurality of second bore portions corresponding to and aligned with the plurality of first bore portions. The first and second bore portions cooperate to form a plurality of receptacles including a plurality of openings in the first surface of the first shielding portion of the housing. The receptacles are sized and configured to receive drug container assemblies, each comprising a container with a container contact region and a seal member disposed adjacent the container contact region to seal the contents of the container at a sealing interface, such that each drug container assembly is exposed out of the housing through one of the openings.

Drug delivery device with retaining member

A drug delivery device is provided for delivering a drug to a target tissue site. The drug delivery device comprises a body comprising a proximal end and a distal end and a chamber disposed therebetween. An upper portion is disposed about the proximal end of the body. A retaining member is disposed within a wall of the body and engageable with the chamber and a plunger is configured for disposal within the upper portion and the chamber. The upper portion is movable about the proximal end of the body to open the chamber such that the plunger is disposed within a passageway defined within the chamber, and movement of the plunger in a distal direction pushes the retaining member such that the drug moves out of the body. Methods are also disclosed.

DRUG DELIVERY DEVICE WITH RETAINING MEMBER

A drug delivery device is provided for delivering a drug to a target tissue site. The drug delivery device comprises a body comprising a proximal end and a distal end and a chamber disposed therebetween. An upper portion is disposed about the proximal end of the body. A retaining member is disposed within a wall of the body and engageable with the chamber and a plunger is configured for disposal within the upper portion and the chamber. The upper portion is movable about the proximal end of the body to open the chamber such that the plunger is disposed within a passageway defined within the chamber, and movement of the plunger in a distal direction pushes the retaining member such that the drug moves out of the body. Methods are also disclosed. 112-. (canceled)13. A drug delivery device for delivering a drug to a target tissue site , the drug delivery device comprising:a body comprising a proximal end and a distal end and a chamber comprising a passageway disposed therebetween, and an external surface comprising a first guide and a second guide;a retaining member disposed within a wall defined by the external surface of the body and engageable with the chamber; andan internal plunger comprising a handle, and configured for disposal within the body, wherein the plunger handle is configured for slidable engagement with the first guide and the second guide and movement of the plunger handle moves the plunger through the passageway of the body and engages with the retaining member such that the drug is dispensed from the delivery device.14. A drug delivery device according to claim 13 , wherein (i) the retaining member comprises a first channel and a second channel; (ii) a needle engages the distal end of the body; or (iii) a needle engages the distal end of the body and the drug is dispensed from the needle as the plunger moves through the body15. A drug delivery device according to claim 14 , wherein the retaining member is rotatable relative to the body and is ...

DELIVERY METHOD FOR PREPARATION AND ADMINISTRATION OF PHARMACEUTICAL COMPOSITIONS

Carpule systems and methods of making and using the same are disclosed. In one embodiment, a carpule system includes a carpule having a carpule body that defines a first chamber and a second chamber. A divider can be disposed between the first and second chambers for isolating a first material in the first chamber from a second material in the second chamber. The carpule system may also include a carpule mixing device that displaces a portion of the divider for mixing the first and second materials to form a mixture and a carpule syringe that dispenses an amount of the mixture. The amount of the mixture being dispensed is measured via an audible sound and/or a tactile sensation provided by the carpule syringe. Systems and methods herein advantageously obviate the need for mixing powdered material via multiple syringes, reduce waste and cost, and improve the accuracy of administering pharmaceutical compositions. 1. A carpule system comprising: a carpule body defining a first chamber and a second chamber; and', 'a divider disposed between the first chamber and the second chamber, wherein the divider is configured to isolate a first material in the first chamber from a second material in the second chamber;, 'a carpule comprisinga carpule mixing device configured to receive the carpule and displace a portion of the divider for mixing the first material with the second material to form a mixture; anda carpule syringe configured to receive the carpule and dispense an amount of the mixture, wherein the amount of the mixture is measurable via an audible sound and/or a tactile sensation provided by the carpule syringe.2. The system of claim 1 , wherein the mixture is disposed in a sealed mixing chamber having a volume that corresponds to volumes of the first and second chambers.3. The system of claim 1 , wherein the carpule mixing device is configured to pneumatically and/or mechanically rupture the divider and to agitate the carpule.4. The system of claim 1 , wherein the ...

SYRINGE CARPULE FOR STORING, TRANSPORTING AND IN SITU MIXING OF LOCAL ANESTHETIC AND BUFFER, AND FOR DELIVERY OF BUFFERED ANESTHETIC SOLUTION AND A PIERCING-MIXING UNIT THEREFORE

A syringe carpule for storing, transporting and in situ mixing of a local anesthetic, such as lidocaine, and a buffer, such as sodium bicarbonate, and delivery of buffered anesthetic solution comprises a hollow tubular body received within the frame of a carpule syringe, at least one axially movable plunger within the body and configured to be engaged and moved by a rod of the carpule syringe, a seal pierced by a rear portion of a needle coupled to the carpule syringe, a first chamber within the body filled with anesthetic solution during storing and transport, a second chamber defined within the body filled with buffering solution during storing and transport; and a breachable separating member between the first and second chamber configured to be removed by a piercing-mixing unit for in situ mixing of the buffering and the anesthetic solutions allowing for delivery of a buffered anesthetic solution. 1. A syringe carpule for storing , transporting , in situ mixing and delivery of a mixed buffered anesthetic solution , comprisingA hollow tubular body configured to be received within the frame of a carpule syringe;At least one axially movable plunger within the tubular body and configured to be engaged and moved by a rod of the carpule syringe;A seal configured to be pierced by a rear portion of a needle coupled to the carpule syringe;A first chamber defined within the hollow tubular body filled with one of an anesthetic solution or a buffering solution during storing and transport;A second chamber defined within the hollow tubular body filled with the other of an anesthetic solution or a buffering solution during storing and transport; andA breachable separating member between the first chamber and the second chamber, wherein the separating member is configured to be breached for in situ mixing of the buffering solution and the anesthetic solution prior to delivery of material to allow for delivery of a buffered anesthetic solution.2. The syringe carpule for storing ...

Applicator for applying a liquid to a location on a body

An applicator for administering a liquid to a selected location of a patient includes a main body having an interior cavity and a flexible outer wall. A frangible ampoule is configured to contain the liquid and configured to be positioned within the interior cavity of the main body. A hypodermic tube having a proximal end attached to the main body and a distal end. An applicator tip attached to the distal end of the hypodermic tube to dispense the liquid.

SURGICAL METHODS EMPLOYING PURIFIED AMPHIPHILIC PEPTIDE COMPOSITIONS

Compositions, methods and delivery devices (e.g., pre-filled syringes) for controlling bleeding during surgical procedures are provided, wherein the compositions are characterized as having an aqueous formulation that is capable of adopting a gelled state upon contact with bodily fluids and/or blood of a patient (i.e., physiological conditions). 171-. (canceled)72. A pre-filled syringe for use in a surgical procedure comprising:a barrel comprising a 0.1-10% peptide solution, wherein the peptide has an amino acid sequence that consists of alternating hydrophilic and hydrophobic amino acids; and wherein the peptide solution is characterized by an ability to transition between two states: an ungelled state adopted when one or more particular ions is substantially absent, and a gelled state adopted when the one or more ions is present at or above a threshold level, wherein the one or more ions is or becomes present in the location; and, a non-metal nozzle; wherein said barrel and non-metal nozzle are capable of forming a secure connection in a liquid-tight manner.7388-. (canceled)89. A liquid composition comprising a peptide , wherein the peptide has an amino acid sequence that consists of alternating hydrophilic and hydrophobic amino acids , for use in a surgical procedure performed at an internal site in a subject's body , which composition is characterized by an ability to transition between two states:an ungelled state adopted when one or more particular ions is substantially absent; anda gelled state adopted when the one or more ions is present at or above a threshold level, wherein the one or more ions is or becomes present in the site when the composition is applied thereto.90. A surgical procedure comprises steps of:(a) making an incision in a body to access a site including a damaged portion of an internal organ or tissue to remove, repair, or replace some or all of the damaged portion during the first period of time;{'claim-ref': {'@idref': 'CLM-00091', 'claim ...

CARTRIDGE HOLD-UP VOLUME REDUCTION

Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed. 1. A drug delivery system , comprising:a cartridge configured to hold a liquid drug;a cartridge stopper positioned in a first portion of the cartridge and including a fluid path pocket;a needle insertion guide positioned adjacent to the cartridge stopper, wherein the needle insertion guide has an opening aligned with the fluid path pocket; anda plunger positioned in a second portion of the cartridge and operable to advance through the cartridge in a direction of the cartridge stopper.2. The drug delivery system of claim 1 , wherein the cartridge stopper is formed from plastic or rubber.3. The drug delivery system of claim 1 , wherein the cartridge stopper is cylindrically-shaped.4. The drug delivery system of claim 1 , wherein the cartridge stopper has a shape operable to fit within a transition region of a neck component of the cartridge claim 1 , and the cartridge stopper is operable to form a seal for the liquid drug.5. The drug delivery system of claim 1 , wherein the needle insertion guide is formed from metal claim 1 , plastic claim 1 , or rubber.6. The drug delivery system of ...

SYRINGE ASSEMBLY, CAP, AND PUNCTURE NEEDLE

A syringe assembly includes a barrel having a barrel tip portion, a puncture needle projecting from the barrel tip portion, and a cap that is detachably mountable to the barrel so as to seal a distal end of a needle hole. The cap has a receiving hole that receives the puncture needle, a bottom wall portion into which the puncture needle is inserted, and a stopper portion that defines an insertion length of the puncture needle relative to the bottom wall portion. In a state in which the cap is mounted to the barrel, the length from the most proximal position of a contact region between the cap and the puncture needle to the most proximal position of an edge surface is 1 to 3 mm. 1. A syringe assembly comprising: a cylindrical barrel body that has an opening at a proximal end thereof, and', 'a barrel tip portion that is disposed at a distal end of the barrel body;, 'a barrel including{'b': '30', 'a puncture needle having an edge surface ( ) and a needle hole, and being held by the barrel tip portion so as to project from the barrel tip portion, the puncture needle having a lubricant-covered region on at least a part of an outer surface thereof; and'}a cap that is detachably mountable to the barrel so as to seal a distal end of the needle hole, a receiving hole configured to receive the puncture needle,', 'a bottom wall portion that is disposed adjacent to a distal end side of the receiving hole and into which the puncture needle is insertable, and', 'a stopper portion that defines an insertion length of the puncture needle relative to the bottom wall portion by abutting against the barrel, and, 'wherein the cap includeswherein, in a state in which the cap is mounted to the barrel, a length from a most proximal position of a contact region between the cap and the puncture needle to a most proximal position of the edge surface is in a range of 1 to 3 mm.2. The syringe assembly according to claim 1 , wherein a length of the edge surface along an axial direction of the ...

CARTRIDGE HOLD-UP VOLUME REDUCTION

Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed. 1. A drug delivery system , comprising:a cartridge configured to hold a liquid drug;a cartridge stopper positioned in a first portion of the cartridge having a first diameter;a needle guide component positioned within the cartridge stopper;a needle positioned within a central opening of the needle guide; anda plunger positioned in a second portion of the cartridge having a second diameter, the second diameter larger than the first diameter, the plunger having a fluid path pocket facing and aligned with the central opening of the needle guide component.2. The drug delivery system of claim 1 , wherein the needle guide component is formed from a metal.3. The drug delivery system of claim 1 , wherein the cartridge stopper is formed from plastic or rubber.4. The drug delivery system of claim 1 , wherein the cartridge stopper is cylindrically-shaped.5. The drug delivery system of claim 4 , wherein the cartridge stopper has a diameter approximately matching the first diameter claim 4 , the cartridge stopper configured to form a seal for the liquid drug.6. The drug delivery system of claim 5 , ...

Botulinum toxin prefilled syringe system

The present invention relates a botulinum toxin prefilled syringe system with desirable injection force characteristics, in particular low gliding force and low break loose force, comprising a syringe barrel of glass containing a liquid botulinum toxin composition, a plunger stopper and a closure device such as a tip cap or a needle shield. In addition, the present invention relates to a kit comprising the botulinum toxin prefilled syringe system, and optionally instructions for use, and to the use of the botulinum toxin prefilled syringe system in therapeutic and cosmetic applications.

Systems and approaches for sterilizing a drug delivery device

A shielding member for use in sterilizing drug container assemblies includes a housing. The housing includes a first shielding portion and a second shielding portion. The first shielding portion includes a first and second surfaces and a plurality of first bore portions extending between. The second shielding portion having a first and second surfaces and a plurality of second bore portions corresponding to and aligned with the plurality of first bore portions. The first and second bore portions cooperate to form a plurality of receptacles including a plurality of openings in the first surface of the first shielding portion of the housing. The receptacles are sized and configured to receive drug container assemblies, each comprising a container with a container contact region and a seal member disposed adjacent the container contact region to seal the contents of the container at a sealing interface, such that each drug container assembly is exposed out of the housing through one of the openings.

DRUG DELIVERY DEVICE WITH RETAINING MEMBER

A drug delivery device is provided for delivering a drug to a target tissue site. The drug delivery device comprises a body comprising a proximal end and a distal end and a chamber disposed therebetween. An upper portion is disposed about the proximal end of the body. A retaining member is disposed within a wall of the body and engageable with the chamber and a plunger is configured for disposal within the upper portion and the chamber. The upper portion is movable about the proximal end of the body to open the chamber such that the plunger is disposed within a passageway defined within the chamber, and movement of the plunger in a distal direction pushes the retaining member such that the drug moves out of the body. Methods are also disclosed. 112-. (canceled)13. A drug delivery device for delivering a drug to a target tissue site , the drug delivery device comprising:a body comprising a proximal end and a distal end and a chamber comprising a passageway disposed therebetween, and an external surface comprising a first guide and a second guide;a retaining member disposed within a wall defined by the external surface of the body and engageable with the chamber; andan internal plunger comprising a handle, and configured for disposal within the body, wherein the plunger handle is configured for slidable engagement with the first guide and the second guide and movement of the plunger handle moves the plunger through the passageway of the body and engages with the retaining member such that the drug is dispensed from the delivery device.14. A drug delivery device according to claim 13 , wherein (i) the retaining member comprises a first channel and a second channel; (ii) a needle engages the distal end of the body; or (iii) a needle engages the distal end of the body and the drug is dispensed from the needle as the plunger moves through the body15. A drug delivery device according to claim 14 , wherein the retaining member is rotatable relative to the body and is ...

ASEPTIC CARTRIDGE AND DISPENSER ARRANGEMENT

A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments, and a fitment. The first compartment contains at least a first constintuent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir. 1. A cartridge for use with a beneficial agent delivery device having a fillable reservoir , said cartridge comprising: a first compartment containing at least a first constituent of the beneficial agent;', 'at least a second compartment containing at least a second constituent of the beneficial agent; and', 'a fitment disposed on said package for interfacing said package to the fillable reservoir., 'a reconstitution, unit dose package, comprising2. The cartridge of wherein the cartridge is adapted to communicate with a delivery portion of the delivery device that comprises one of a needle claim 1 , a connector and a nozzle.3. The cartridge of wherein the delivery portion comprises a needle claim 1 , and wherein said fitment seals around the needle to minimize fluidic dead-space.4. The cartridge of further comprising a rupturable barrier between said first compartment and said fitment.5. The cartridge of wherein said first compartment is segregated from said second compartment by a rupturable barrier.6. The cartridge of wherein at least a portion of said package comprises a flexible wall.7. The cartridge of wherein at least a portion of said flexible wall comprises a foil.8. The cartridge of wherein at least a portion of said flexible wall is preformed to define at least a portion of said first and second compartments.9. The cartridge of wherein at least a portion of said flexible wall comprises a peelable foil layer.10. The cartridge of wherein at least a portion of said peelable foil layer is preformed.11 ...

BENEFICIAL AGENT DISPENSER

A dispensing device for use with a beneficial agent has a dispensing package, a dispenser disposed on an end portion of the dispensing package, and an actuator movably disposed along at least a portion of the package between a pre-dispensing state and a dispensing state. One arrangement also provides a beneficial agent dispenser having a dispensing port, an elongate portion and a plunger that is movably disposed relative to a tubular wall of the elongate portion during a dispensing stroke to partially penetrate a separable barrier and expel the beneficial agent through the dispensing port. 145-. (canceled)46. A dispensing device for use with a beneficial agent , comprising: an elongate, at least partially flexible member comprising a sealed, pre-formed tubular compartment and at least one separable barrier enclosing one end of said tubular compartment, wherein said tubular compartment includes at least a first compartment; and', 'one of a beneficial agent or a constituent of a beneficial agent contained in said tubular compartment;, 'a dispensing package, comprisinga dispenser disposed on a dispensing end portion of said dispensing package; anda pressure chamber enclosing at least a portion of said tubular compartment and configured such that elevated pressure in said pressure chamber results in expulsion of said beneficial agent or constituent of a beneficial agent from at least said tubular compartment.47. The dispensing device according to wherein said separable barrier is formed along a tubular wall of said tubular compartment by pinching said one end of said tubular compartment and thereafter sealing across said one end.48. The dispensing device according to wherein said separable barrier defines a distal end of said tubular compartment.49. The dispensing device according to wherein said separable barrier defines a proximal end of said first compartment.50. The dispensing device according to wherein said first compartment stores a first constituent of the ...

A Pharmaceutical Component-Mixing Delivery Assembly

There is described a pharmaceutical component-mixing delivery assembly comprising: a first cartridge and a second cartridge; the first and second cartridges being dimensioned so that they are movable relative to one another such that the first cartridge is slidable within the second cartridge from a pre-mixed position to a post-mixed position; the first cartridge comprising a body provided with an outlet end, the first cartridge being fitted with plunger and containing a first pharmaceutical component; the second cartridge comprising a body provided with an inlet end and an outlet end, the second cartridge containing a second pharmaceutical component; and wherein the first and second cartridges are separated by a non-invasive valve component. 1. A pharmaceutical component-mixing delivery assembly comprising:a first cartridge and a second cartridge;the first and second cartridges being dimensioned so that they are movable relative to one another such that the first cartridge is slidable within the second cartridge from a pre-mixed position to a post-mixed position;the first cartridge comprising a body provided with an outlet end, the first cartridge being fitted with plunger and containing a first pharmaceutical component;the second cartridge comprising a body provided with an inlet end and an outlet end, the second cartridge containing a second pharmaceutical component; andwherein the first and second cartridges are separated by a non-invasive valve component and the non-invasive valve component is generally elongated, the length of non-invasive valve component being chosen so that, as the mixing chamber expands longitudinally, the pharmaceutical components never come into contact with the non-aseptic walls of the second cartridge thus maintaining sterility at all times.2. A pharmaceutical component-mixing delivery assembly according to wherein the non-invasive valve component is provided with a terminal rib to improve the seal formed between the non-invasive valve ...

Device for extracting a fluid from an ampoule

A device for extracting a fluid from an ampoule, comprising a plunger body () arranged for enclosing an ampoule (), and a syringe body () movable relative to the plunger body (). The syringe body () comprises a piston member () and an outer tubular casing () concentrically arranged around the piston member (). The piston member () comprises an insertion end (), receivable within the plunger body () and arranged for insertion in the ampoule (), an ejection end () attached to the outer tubular casing (), and a lumen () extending between the insertion end () and the ejection end (). The plunger body () and the syringe body () form an actuating arrangement of the device () arranged to move the piston member () through the ampoule () during operation and forcing a fluid from the ampoule () through the lumen (). 1. A device for extracting a fluid from an ampoule , comprisinga plunger body arranged for enclosing an ampoule, and a syringe body, the plunger body being movable relative to the syringe body, the syringe body having a piston member and an outer tubular casing arranged concentrically around the piston member,wherein the piston member comprises an insertion end receivable within the plunger body and arranged for insertion in the ampoule, an ejection end attached to the outer tubular casing, and a lumen extending between the insertion end and the ejection end,wherein the plunger body and the syringe body form an actuating arrangement of the device arranged to move the piston member through the ampoule during operation and forcing a fluid from the ampoule through the lumen.2. The device according to claim 1 , wherein the device further comprises a container part with an attachment portion connectable to the ejection end of the piston member.3. The device according to claim 2 , wherein the container part comprises an aperture opposite to the attachment portion.4. The device according to claim 1 , wherein the device further comprises a sealing member having a first ...

MEDICAMENT DELIVERY DEVICE

A medicament delivery device is provided. The medicament delivery device may include, among other features, a cartridge holder mounted in a housing and configured to receive a cartridge containing a medicament. The device may also include an outer cap detachably connected to the housing, and a coupling mechanism configured to connect the outer cap to an injection needle holder to which an injection needle is fixed. The coupling mechanism may include a rotatable member configured to be connected to an injection needle holder. The coupling mechanism may also be threadedly engaged with, and rotatable to, the outer cap. The configuration of the device may allow for quicker and more efficient delivery of medicament. 1. A medicament delivery device comprising:a cartridge holder mounted in a housing and configured to receive a cartridge containing a medicament, the housing comprising a longitudinal axis;an outer cap detachably connected to the housing; anda coupling mechanism configured to connect the outer cap to an injection needle holder to which an injection needle is fixed, the injection needle comprising a proximal end and a distal end;wherein the coupling mechanism comprises a rotatable member which is configured to be connected to an injection needle holder and which is threadedly engaged with the outer cap and is rotatable relative to the outer cap, and wherein the coupling mechanism is configured such that pulling the outer cap away from the cartridge holder in a first axial direction along the longitudinal axis causes rotational movement of the rotatable member and thereby of an injection needle holder connected thereto, about the longitudinal axis and translational movement of the rotatable member and thereby a connected injection needle holder relative to the housing in a second axial direction opposed to the first axial direction such that the injection needle holder moves from a storage position in which, when the cartridge is received in the cartridge ...

DRUG DELIVERY DEVICE WITH STERILE FLUID FLOWPATH AND RELATED METHOD OF ASSEMBLY

Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing and a container disposed therein. The container may include a reservoir containing a drug and a movable stopper. A first seal member may be connected to the container at a distal end of the reservoir. A first removable membrane may cover an exterior surface of the first seal member to maintain sterility of that surface prior to operation of the device. A fluid pathway assembly may be configured to establish fluid communication with the reservoir during operation of the device. A second seal member may be connected to a first end of the fluid pathway assembly. A second removable membrane may cover an exterior surface of the second seal member to maintain sterility of that surface prior to operation of the device. 1. A drug delivery device comprising:a housing defining an interior space;a container disposed in the interior space and including a reservoir containing a drug and a stopper, the stopper being movable through the reservoir from a proximal end of the reservoir toward a distal end of the reservoir to expel the drug from the reservoir during operation of the drug delivery device;a first seal member connected to the container at the distal end of the reservoir;a first removable membrane covering an exterior surface of the first seal member to maintain sterility of the exterior surface of the first seal member prior to operation of the drug delivery device;a fluid pathway assembly configured to establish fluid communication with the reservoir during operation of the drug delivery device and having a first end, a second end, and a fluid passage extending between the first end and the second end;a second seal member connected to the first end of the fluid pathway assembly; anda second removable membrane covering an exterior surface of the second seal member to maintain sterility of the exterior surface of the second seal member prior to operation of ...

INJECTION OR INFUSION DEVICE COMPRISING AN IMPROVED RELEASE LINER

An injection device configured for attachment to the skin of a patient using an adhesive layer includes a release liner covering the adhesive layer thereby preventing skin attachment. The release liner comprises a sheet of material where a first surface contacts the adhesive layer, and an aperture defining a passage for a film connected to a first sterile barrier film located within the injection device. An end of the film is connected to a second surface of the sheet of material that is opposite to the first surface, and the release liner is covered by a strengthening sheet connected to the second surface and covering the aperture and the end of the film. 2. The injection device according to claim 1 , wherein the release liner further comprises a second aperture for a hollow needle claim 1 , wherein an end of the hollow needle is configured to be moved from a first position within the injection device to a second position outside the injection device claim 1 , and wherein the second aperture is covered by a removable second sterile barrier film attached to the strengthening sheet.3. The injection device according to claim 2 , wherein the first sterile barrier film forms a removable sterile barrier within the injection device covering a passage on an inside of the injection device.4. The injection device according to claim 3 , wherein the passage on the inside of the injection device is a part of a sterile compartment enclosing a fluid path comprising a fluid path needle configured to be moved within the injection device through the passage into a septum of a cartridge claim 3 , wherein the first sterile barrier film maintains the sterile compartment in a sterile condition when covering the passage.5. The injection device according to claim 4 , wherein the first sterile barrier film forms a removable sterile barrier within the injection device covering the septum of the cartridge and maintains a surface of the septum in a sterile condition.6. The injection device ...

INJECTION OR INFUSION DEVICE COMPRISING AN IMPROVED HOUSING AND RELEASE LINER FOR REMOVING STERILE BARRIER FILMS USING THE RELEASE LINER

An injection device configured for attachment to the skin of a patient includes a housing and a skin adhesive layer attached to an external surface of the housing for attaching the injection device to the skin of a patient. A release liner covering the skin adhesive layer prevents the injection device from attaching to the skin. A film with one end connected to a surface inside of the housing forms a removable sterile barrier and the other end connected to an external surface of the release liner without contacting the skin adhesive layer. The housing, skin adhesive layer and release liner each include a notch defining a passage for the film so that the second end of the film can extend from the interior to the exterior of the housing. 1. An injection device configured for attachment to skin of a patient , comprisinga housing;a skin adhesive layer coupled to an outside surface of the housing configured for attaching the injection device to the skin of the patient,a release liner covering the skin adhesive layer thereby preventing skin attachment of the injection device,a first film comprising a first end and a second end, wherein the first end is coupled to an internal surface of the housing and forms a removable sterile barrier, and wherein the second end is coupled to an exterior surface of the release liner without contacting the skin adhesive layer,wherein each of the housing, the skin adhesive layer and the release liner comprises a notch, wherein the notches define a passage extending between an interior of the housing to an exterior of the housing, and wherein the second end of the first film extends through the passage to the exterior of the housing.2. The injection device according to claim 1 , wherein at least one of the notches comprises a U-shaped aperture defining a notch opening configured to receive the first film.3. The injection device according to claim 2 , further comprising a second film claim 2 , the second film comprising a first end and a ...

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Multi-stage delivery system

A multi-stage drug delivery system having a cartridge and multiple plungers positioned in the cartridge and spaced apart from one another is provided. A first plunger, a second plunger, and the cartridge form a first chamber storing a first drug. The second plunger and the cartridge form a second chamber storing a second drug. A cannula pierces the first plunger to access the first drug. As the first plunger is driven toward the second plunger, the first drug is expelled from the first chamber for delivery to a patient through the cannula. After expelling the first liquid drug, the cannula can pierce the second plunger to access the second drug. As the first and second plungers are together driven toward a closed end of the cartridge, the second liquid drug is expelled from the second chamber for delivery to the patient through the cannula.

Cartridge hold-up volume reduction

Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed.

Multi-stage delivery system

A multi-stage drug delivery system having a cartridge and multiple plungers positioned in the cartridge and spaced apart from one another is provided. A first plunger, a second plunger, and the cartridge form a first chamber storing a first drug. The second plunger and the cartridge form a second chamber storing a second drug. A cannula pierces the first plunger to access the first drug. As the first plunger is driven toward the second plunger, the first drug is expelled from the first chamber for delivery to a patient through the cannula. After expelling the first liquid drug, the cannula can pierce the second plunger to access the second drug. As the first and second plungers are together driven toward a closed end of the cartridge, the second liquid drug is expelled from the second chamber for delivery to the patient through the cannula.

표시기

액상 약제을 전달하기 위한 자동 주사기로서, 액상 약제를 수용하기 위한 접이식 용기(26); 개방 가능한 클로저; 및 상기 강성 외부 용기(22) 내부에 적어도 일부가 위치하고, 상기 개방가능한 클로저가 개방될 경우 상기 접이식 용기의 원위 말단 쪽으로 종방향으로 이동하도록 배치되는 연장 표시 부재로서, 상기 연장 표시 부재의 종방향 이동이 상기 자동 주사기의 사용자에게 주입 과정에 대해 시각, 및/또는 청각 및/또는 촉각 피드백을 생성하는 연장 표시 부재를 더 포함한다.

用于药剂输送装置的给药组件

本公开涉及一种用于药剂输送装置的给药组件，包括：细长的管状输送构件护盖(7)；药筒保持架(11)，配置为由输送构件护盖(7)接收并配置为容纳药筒(31)，该药筒保持架(11)具有在径向上为柔性的并且径向向内延伸的药筒阻挡突起(11b)，该药筒阻挡突起(11b)配置为在受到大于阈值的指向近侧的力之前阻止药筒(31)向近侧移动；针头组件(13)，该针头组件(13)包括具有向近侧延伸的针头部分(13a)和向远侧延伸的针头部分(13b)的双刃针头，其中该针头组件(13)配置为与药筒保持架(11)组装在一起，从而使向远侧延伸的针头部分(13b)延伸到药筒保持架(11)中；以及给药机构，该给药机构包括配置为向近侧偏置的柱塞杆(27)，其中所述输送构件护盖(7)配置为相对于药筒保持架(11)向远侧方向直线位移，并且其中输送构件护盖(7)配置为在向远侧方向移动时激活给药机构，使得给药机构向近侧方向移动药筒保持架(11)，并随后以大于阈值的力在药筒保持架(11)内向近侧方向移动柱塞杆(27)。

Surgical method using purified amphipathic peptide composition

Arrangement for storing, transporting and administering a liquid

An arrangement for storing, transporting and administering a liquid, such as a medical liquid, comprises a syringe barrel. The proximal end of the syringe barrel is closed with a proximal closure element. At the distal end, there is a distal closure element. The two closure elements are connected to one another in a clip-like fashion via a connection element. At least one predetermined breaking point is provided between the two closure elements and the connection element. Thus, a tamper-evident closure for a syringe is formed.

Syringe for holding vacuum in storage state

FIELD: medicine. SUBSTANCE: present invention refers to medical equipment, namely to syringes for retention and mixing of the first and second substances. Syringe comprises a cylinder comprising a sealed and/or closable distal outlet and a vacuum chamber for holding the first substance in a vacuum, plunger, comprising chamber-reservoir for accommodation of second substance and made with possibility of axial displacement through proximal end of cylinder, a membrane separating the vacuum chamber and the reservoir chamber, and a pointed element, such as one or more needles, for piercing the membrane. Said syringe is made so that vacuum in vacuum chamber causes axial displacement of plunger from first position to a predetermined second position in cylinder, and said axial displacement of the plunger causes a membrane puncture with a pointed element and creates a fluid passage between the reservoir chamber and the vacuum chamber, wherein the vacuum in the vacuum chamber sucks the second substance into the vacuum chamber, thereby transferring the contents of the reservoir chamber into the vacuum chamber without displacing the plunger from said preset second position. EFFECT: disclosed is a syringe for holding vacuum in a storage state. 22 cl, 3 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 717 356 C2 (51) МПК A61M 5/20 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A61M 5/20 (2020.01) (21)(22) Заявка: 2018103401, 30.06.2016 (24) Дата начала отсчета срока действия патента: Дата регистрации: (73) Патентообладатель(и): ФЕРРОСАН МЕДИКАЛ ДИВАЙСИЗ А/С (DK) 23.03.2020 03.07.2015 EP 15175189.8 (43) Дата публикации заявки: 06.08.2019 Бюл. № 22 (56) Список документов, цитированных в отчете о поиске: US 3405712 A, 15.10.1968. US 2006052747 A1, 09.03.2006. US 2012201726 A1, 09.08.2012. RU 2003129514 A, 10.04.2005. (45) Опубликовано: 23.03.2020 Бюл. № 9 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 05.02.2018 ...

Drug delivery device with sterile fluid flowpath and related method of assembly

Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing and a container disposed therein. The container may include a reservoir containing a drug and a movable stopper. A first seal member may be connected to the container at a distal end of the reservoir. A first removable membrane may cover an exterior surface of the first seal member to maintain sterility of that surface prior to operation of the device. A fluid pathway assembly may be configured to establish fluid communication with the reservoir during operation of the device. A second seal member may be connected to a first end of the fluid pathway assembly. A second removable membrane may cover an exterior surface of the second seal member to maintain sterility of that surface prior to operation of the device.

Systems and approaches for sterilizing a drug delivery device

A shielding member for use in sterilizing drug container assemblies includes a housing. The housing includes a first shielding portion and a second shielding portion. The first shielding portion includes a first and second surfaces and a plurality of first bore portions extending between. The second shielding portion having a first and second surfaces and a plurality of second bore portions corresponding to and aligned with the plurality of first bore portions. The first and second bore portions cooperate to form a plurality of receptacles including a plurality of openings in the first surface of the first shielding portion of the housing. The receptacles are sized and configured to receive drug container assemblies, each comprising a container with a container contact region and a seal member disposed adjacent the container contact region to seal the contents of the container at a sealing interface, such that each drug container assembly is exposed out of the housing through one of the openings.

System and approaches for sterilizing a drug delivery device

A drug delivery sterilization system includes a housing defining at least one receptacle, a container assembly having first and second ends, an elongated portion extending therebetween, and an electron beam or x-ray generator disposed near the housing. The container assembly includes a container having a container contact region at the second end and an inner volume to contain a medicament, a seal member having a seal member contact region to form a sealing interface with the container contact region, and a coupling device adapted to sealingly couple the seal member to the container. The container assembly is at least partially disposed in the receptacle such that the second end of the container is exposed through the housing. The electron beam or x-ray generator generates a sterilizing beam that penetrates the seal member to sterilize the sealing interface.

Dual medicament carpule for dental syringes

A carpule for a dental syringe provides an internal piston disposed between a front septum and a rear plunger. The internal piston is hollow and includes a thin membrane front. The internal piston is designed to offer minimum resistance to movement in the carpule body to allow for aspiration and for easy dispensing. The internal piston divides the carpule into two anesthetic chambers, allowing an anesthetic without a vasoconstrictor and an anesthetic with a vasoconstrictor to be dispensed sequentially in a single injection and without causing undue trauma to the patient.

Drug delivery device

本申请涉及一种药物递送设备(100)，其用于通过套管(134)将药物从药筒(10)递送到注射部位中。该药筒具有带出口(15)的药物腔室(14)和用于关闭出口(15)的密封元件(16)。该设备具有用于接收药筒(10)的壳体(102)和驱动机构(200)，该驱动机构(200)在驱动机构(200)被激活后将药物从该设备中排出。该设备具有包括轮毂(166)和弹簧器件(184)的连接装置(199)，所述弹簧器件用于在操作构件(190)操作时驱动轮毂(166)和药筒(10)之间的相对移动。该操作构件将连接装置(199)从未连接配置切换到连接配置，其中轮毂(166)与药筒(10)协作以打开出口(15)。当连接时，流体可以在腔室(14)和套管(134)之间流动。

SINGLE USE INJECTION DEVICE FOR PRE-FILLED

Multiple septum cartridge for medication dispensing device

一种用于药物配送装置，其包括多个隔膜的药筒。该药筒包括一主体和一可沿轴向移动的柱塞，该柱塞以液密形式与主体的内表面相接合。第一隔膜在近端位置覆盖着通向主体内腔的配送孔。第二隔膜覆盖着通向该内腔的加注孔。该第一隔膜用来与配送导管相接合，该导管大体上垂直于该轴线方向，以便在该装置的配送操作期间与该内腔流体地连通。该第二隔膜用来与加注导管相接合，以便在药筒加注期间与该内腔流体地连通。

Indicating device

Изобретение относится к медицинской технике, а именно к автоматическому инъекционному устройству для доставки жидкого лекарственного средства. Устройство содержит: жесткую внешнюю емкость; сжимаемую емкость для размещения в ней жидкого лекарственного средства, расположенную внутри жесткой внешней емкости и имеющую проксимальный конец и дистальный конец; открываемый закрывающий элемент, соединенный с дистальным концом сжимаемой емкости для удержания жидкого лекарственного средства внутри сжимаемой емкости; средства инъекции, соединенные с открываемым закрывающим элементом для доставки жидкого лекарственного средства из сжимаемой емкости, и средства создания давления, расположенные внутри жесткой внешней емкости и обеспечивающие усилие, действующее на проксимальный конец сжимаемой емкости и толкающее проксимальный конец сжимаемой емкости по направлению к дистальному концу сжимаемой емкости, что приводит к оказанию давления на жидкое лекарственное средство, содержащееся в сжимаемой емкости, таким образом, что обеспечена возможность поддержки жидкого лекарственного средства под давлением во время хранения и доставки жидкого лекарственного средства через средства инъекции после открытия открываемого закрывающего элемента. Причем автоматическое инъекционное устройство дополнительно содержит: удлиненный индикаторный элемент, расположенный по меньшей мере частично внутри жесткой внешней емкости и выполненный с возможностью перемещения в продольном направлении к дистальному концу сжимаемой емкости после открытия открываемого закрывающего элемента. Причем перед инъекцией конец удлиненного индикаторного элемента выступает за проксимальный конец жесткой внешней емкости. При этом перемещение удлиненного индикаторного элемента в продольном направлении приводит к получению визуального, звукового и/или тактильного ответных сигналов, что информирует пользователя автоматического инъекционного устройства о степени продвижения процесса инъекции после его начала. 22 з.п. ф-лы, 9 ил. ...

Injecting device for liquid medicine by unit connection

A liquid medicine injection device of the present invention comprises: a liquid medicine cartridge having a liquid medicine cartridge body provided with a liquid medicine cartridge chamber having a liquid medicine stored therein, a liquid medicine cartridge rear coupling part provided at the rear end of the liquid medicine cartridge body, a liquid medicine cartridge front coupling part provided at the front end of the liquid medicine cartridge body to correspond to the liquid medicine cartridge rear coupling part, and a liquid medicine cartridge rear shielding film and a liquid medicine cartridge front shielding film provided at the rear end and the front end of the liquid medicine cartridge body, respectively, to shield the liquid medicine cartridge chamber; a piston which enters from the liquid medicine cartridge rear coupling part into the liquid medicine cartridge chamber to extrude the liquid medicine toward the liquid medicine cartridge front coupling part; and a needle connected to the liquid medicine cartridge to inject, into the body, the liquid medicine extruded from the liquid medicine cartridge, wherein one or multiple liquid medicine cartridges may be disposed between the piston and the needle, and the multiple liquid medicine cartridges, which are disposed between the piston and the needle, are connected to enable liquid medicines to flow together by a method of coupling the liquid medicine cartridge rear coupling part and the liquid medicine cartridge front coupling part.

Prefilled syringe formulation with needle with syringe cap

Bone cement applicator with the closed system driven by bone cement dough

本发明涉及一种用于混合和施加骨水泥的骨水泥施加器，骨水泥的起始组分(1，2)可以在封闭的料筒(3，4)中混合成骨水泥料团(44)，料筒(3，4)具有由多个部件构成的、包括排出口的封闭系统，封闭系统的至少两个部件(7，8)可以通过混合的骨水泥料团(44)的运动驱动地彼此相对地运动，通过封闭系统的至少两个部件(7，8)的这种彼此相对的运动使排出口打开，混合的骨水泥料团(44)的运动可以通过在骨水泥料团(44)上的压力驱动。本发明还涉及一种用于混合起始组分(1，2)的方法。

Multi-chamber, sequential dose dispensing syringe

A valve assembly is disclosed which effectively partitions a syringe into proximal and distal chambers to provide a multi-chamber, sequentially dispensing syringe apparatus. The valve assembly may be effectively used with a variety of standard, currently available commercial syringes and pre-filled syringes. Incorporated in the valve assembly is a valved stopper having a valve (which may be a slit valve), an impact sensor which opens the valve upon impact between the valve assembly and internal distal end of the syringe and a gas separator which separates liquid from gas disposed in the proximal chamber to assure gas is not delivered therefrom. The valve assembly is displaced as a plunger of the syringe is displaced via communication through fluid in the proximal chamber of the syringe. The actuator has a latching feature which latches the valve to an open state after being opened by the impact sensor. The gas separator has a proximally disposed orifice which facilitates priming. The valve assembly may be made from two parts. One part, a valved stopper, may be molded from the same rubber based material used in syringe plunger stoppers. The second part, the valve actuator, may be injection molded as a single part. A synthetic resinous material which is compatible with manufacture of living hinges my be used for the second part. Multiple valve assemblies may be used in a single syringe barrel.

Medicament delivery device and methods for delivering drugs to infants and children

A method of delivering epinephrine includes placing a distal end surface of a medical injector into contact with a target location of a patient. The medical injector includes a housing, an energy storage member, and a medicament container containing a dose of epinephrine effective for administration to the patient experiencing anaphylaxis and having a weight of less than 15 kg. The medicament container is coupled to a needle. The medical injector is actuated such that the energy storage member produces a force to move the needle from a first needle position to a second needle position. A distal tip of the needle extends from the distal end surface by a distance of between 7 millimeters and 8 millimeters when the needle is in the second needle position. A portion of the force is exerted to expel the dose of epinephrine when the needle is in the second position.

Administration assembly for a medicament delivery device

本發明關於一種用於藥物輸送裝置的施用組合體。該施用組合體包含：修長管狀輸送構件遮蔽件(7)；匣保持器(11)，具有匣阻擋凸部(11b)，該匣阻擋凸部被建構用於防止藥物匣(31)朝近側運動，直到藥物匣受到朝近側的力為止；針組合體(13)，包括雙刃針，該雙刃針具有近側延伸針部(13a)和遠側延伸針部(13b)，其中該針組合體(13)被建構用於被組合於該匣保持器(11)，使得該遠側延伸針部(13b)延伸進入該匣保持器(11)；和施用機構，包括柱塞桿(27)，該柱塞桿被建構用於朝近側偏壓。其中該輸送構件遮蔽件(7)被建構用於相對於該匣保持器(11)朝遠側方向線性位移；且其中該輸送構件遮蔽件(7)被建構用於當該輸送構件遮蔽件朝該遠側方向運動時，啟動了該施用機構，造成該施用機構朝該近側方向運動該匣保持器(11)，且接下來以大於臨界值的力將該匣保持器(11)內側的該柱塞桿(27)朝該近側方向運動。

Medicament delivery device and methods for delivering drugs to infants and children

A method of delivering epinephrine includes placing a distal end surface of a medical injector into contact with a target location of a patient. The medical injector includes a housing, an energy storage member, and a medicament container containing a dose of epinephrine effective for administration to the patient experiencing anaphylaxis and having a weight of less than 15 kg. The medicament container is coupled to a needle. The medical injector is actuated such that the energy storage member produces a force to move the needle from a first needle position to a second needle position. A distal tip of the needle extends from the distal end surface by a distance of between 7 millimeters and 8 millimeters when the needle is in the second needle position. A portion of the force is exerted to expel the dose of epinephrine when the needle is in the second position.

Applicator for applying a liquid to a location on a body

An applicator (10) for administering a liquid to a selected location of a patient includes a main body (12) having an interior cavity (17) and a flexible outer wall (14). A frangible ampoule (18) is configured to contain the liquid (20) and configured to be positioned within the interior cavity (17) of the main body (12). A hypodermic tube (42) has a proximal end (40) attached to the main body (12) and a distal end (43). An applicator tip (44) is attached to the distal end (43) of the hypodermic tube (42) to dispense the liquid (20).

Drug delivery device with sterile fluid flowpath and related method of assembly.

Se dan a conocer dispositivos de administración de fármacos y métodos relacionados de ensamblaje. El dispositivo de administración de fármacos puede incluir una carcasa y un recipiente dispuesto en la misma. El recipiente puede incluir un dispositivo que contiene un fármaco y un tapón móvil. Un primer elemento de sellado puede conectarse al recipiente en un extremo distal del depósito. Una primera membrana retirable puede cubrir una superficie exterior del primer elemento de sellado para mantener la esterilidad de esa superficie antes del funcionamiento del dispositivo. Un conjunto de trayectoria del fluido puede configurarse para establecer la comunicación del fluido con el depósito durante el funcionamiento del dispositivo. Un segundo elemento de sellado puede conectarse a un primer extremo del conjunto de trayectoria del fluido. Una segunda membrana retirable puede cubrir una superficie exterior del segundo elemento de sellado para mantener la esterilidad de esa superficie antes del funcionamiento del dispositivo.

PRE-FILLED, EASILY READY TO USE INJECTION SYRINGE

Syringe for mixing two components and for maintaining vacuum under storage conditions

本发明涉及一种用于混合两种物质的注射器，所述两种物质已经例如在储存条件下分开地保留在注射器内。具体地说，本发明涉及一种注射器，其用于1)将干组分保留在真空中，以及2)将干组分与水性介质混合以形成可流动物质。一个实施方式涉及用于保留和混合第一和第二物质的注射器，其包括：包括可密封和/或可封闭的远侧出口和用于容纳第一物质的真空腔室的圆筒，结合有用于容纳第二物质的储存腔室并且构形成轴向地移动通过圆筒的近端的柱塞，分隔真空腔室和储存腔室的隔膜，以及用于刺穿隔膜的尖锐构件，诸如一个或多个针。

Apparatus and method for storing and mixing a bone cement

Vorrichtung zum Mischen eines Polymethylmethacrylat-Knochenzements aus zwei Ausgangskomponenten (1, 2) und zum Lagern der Ausgangskomponenten (1, 2) des Knochenzements aufweisend eine rohrförmige Kartusche (3, 4, 46, 50) mit einem zylindrischen Innenraum, wobei in einem vorderen Teil des Innenraums der Kartusche (3, 4, 46, 50) ein Pulver (1) als erste Ausgangskomponente enthalten ist und in einem hinteren Teil des Innenraums der Kartusche (3, 4, 46, 50) ein Behälter (9) enthaltend eine Monomerflüssigkeit (2) als zweite Ausgangskomponente angeordnet ist, wobei zwischen dem Behälter (9) und dem Pulver (1) ein Austragskolben (6) angeordnet ist und wobei auf der dem Austragskolben (6) gegenüberliegenden Seite des Behälters (9) ein Förderkolben (5) angeordnet ist, wobei der Austragskolben (6) und der Förderkolben (5) in Längsrichtung beweglich im Innenraum der Kartusche (3, 4, 46, 50) angeordnet sind, wobei ein Leitungsmittel (22) vorgesehen ist, das den vorderen Teil und den hinteren Teil des Innenraums der Kartusche (3, 4) miteinander für die Monomerflüssigkeit (2) und für Gase durchlässig verbindet und das für das Pulver (1) undurchlässig ist. Apparatus for mixing a polymethyl methacrylate bone cement from two starting components (1, 2) and for supporting the starting components (1, 2) of the bone cement comprising a tubular cartridge (3, 4, 46, 50) with a cylindrical interior, wherein in a front part in the interior of the cartridge (3, 4, 46, 50) a powder (1) is contained as a first starting component and in a rear part of the interior of the cartridge (3, 4, 46, 50) a container (9) containing a monomer liquid ( 2) is arranged as a second output component, wherein between the container (9) and the powder (1) a discharge piston (6) is arranged and wherein on the discharge piston (6) opposite side of the container (9) arranged a delivery piston (5) is, wherein the discharge piston (6) and the delivery piston (5) are arranged longitudinally movable in the interior of ...

Pre-filled syringe preparation with needle, which is equipped with syringe cap

Pre-filled syringe preparation with needle, which is equipped with syringe cap

막힘을 일으키지 않고서 간편하게 공업적 제조를 할 수 있는 고농도 항체 함유 침 부착 프리필드 시린지 제제를 제공하는 것. 단백질 용액을 봉입한 침 부착 프리필드 시린지 제제로서, 당해 침에 수증기 투과성이 낮은 소재로 형성된 캡을 구비하는 것을 특징으로 하는 프리필드 시린지 제제. To provide a needle-attached prefilled syringe formulation containing a high concentration of antibody that can be easily industrially manufactured without clogging. A prefilled syringe formulation with a needle encapsulated with a protein solution, the prefilled syringe formulation comprising a cap made of a material having low water vapor permeability to the needle.

Pre-filled syringe preparation with needle with syringe cap

提供不產生Clogging，可於工業上簡便地製造的含有高濃度抗體之附針預填充注射器製劑。 一種預填充注射器製劑，其係封入有蛋白質溶液之附針預填充注射器製劑，其特徵為於該針係具備以水蒸氣透過性低之素材所形成的蓋。

Syringe system pre-filled with botulinus toxin

Настоящее изобретение относится к медицинской технике, а именно к предварительно заполненной ботулиническим токсином шприцевой системе с требуемыми характеристиками усилия при инъекции, в частности с низким усилием для перемещения поршня и низким усилием для приведения поршня в действие, включающей в себя стеклянный цилиндр шприца, содержащий жидкую композицию ботулинического токсина, уплотнитель и закрывающее устройство, такое как колпачок наконечника или колпачок иглы. Кроме того, настоящее изобретение относится к комплекту, содержащему предварительно заполненную ботулиническим токсином шприцевую систему и, при необходимости, инструкции по применению, а также к использованию предварительно заполненной ботулиническим токсином шприцевой системы в терапевтических и косметических целях. 3 н. и 12 з.п. ф-лы, 5 ил., 4 табл. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 745 739 C2 (51) МПК A61M 5/315 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A61M 5/315 (2021.01) (21)(22) Заявка: 2018133772, 20.06.2017 (24) Дата начала отсчета срока действия патента: (73) Патентообладатель(и): МЕРЦ ФАРМА ГМБХ ЭНД КО. КГАА (DE) Дата регистрации: 31.03.2021 22.06.2016 EP 16001404.9 (43) Дата публикации заявки: 22.07.2020 Бюл. № 21 (45) Опубликовано: 31.03.2021 Бюл. № 10 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 22.01.2019 2 7 4 5 7 3 9 (56) Список документов, цитированных в отчете о поиске: EP 2910265 A1, 26.08.2015. WO 2013178647 A1, 05.12.2013. WO 2016039816 A1, 17.03.2016. Приоритет(ы): (30) Конвенционный приоритет: R U 20.06.2017 (72) Автор(ы): ФОГТ Маркус (DE) EP 2017/065050 (20.06.2017) C 2 C 2 (86) Заявка PCT: (87) Публикация заявки PCT: R U 2 7 4 5 7 3 9 WO 2017/220553 (28.12.2017) Адрес для переписки: 190000, Санкт-Петербург, БОКС-1125 (54) ПРЕДВАРИТЕЛЬНО ЗАПОЛНЕННАЯ БОТУЛИНИЧЕСКИМ ТОКСИНОМ ШПРИЦЕВАЯ СИСТЕМА (57) Реферат: Настоящее изобретение относится к как колпачок наконечника или колпачок иглы. ...

Syringe for mixing two components and for retaining a vacuum in a storage condition

A syringe for mixing two substances which have been retained separately inside the syringe is described, for instance in a storage condition. The syringe is used for 1) retaining a dry composition in a vacuum, and 2) mixing the dry composition with an aqueous medium to form a flowable substance. One embodiment, a syringe for retaining and mixing first and second substances comprises a barrel comprising a sealable and/or closable distal outlet and a vacuum chamber for holding a first substance, a plunger incorporating a reservoir chamber for holding a second substance and configured to be axially displaced through a proximal end of the barrel, a membrane separating the vacuum chamber and the reservoir chamber, and a pointed member, such as one or more needles, for penetrating the membrane, wherein the syringe is configured such that the membrane and the pointed member are axially slidable in relation to each other.

Method for producing a cartridge

A method for producing a cartridge is proposed, wherein a fluid is filled into an opening of a container and a closure part is inserted into the container, thereby moving a movable piston arranged within the container.

Automatic injection syringe with a body forming an ampoule

The present invention relates to an automatic injection syringe of the type comprising a syringe body 11, a needle 12 connected to its needle holder 14 by way of a needle guide 13, and a propulsion device 16, the said syringe having a rest position in which the needle 12 is housed inside the body 11, and an active position in which the said needle protrudes outside the body 11, the said syringe being characterised in that a substance to be injected 17 is housed inside the said body between two leakproof plungers 15, 20 and is in direct contact with the wall of the said body. Such a syringe has the advantage of not including any ampoule, and this reduces its manufacturing cost and facilitates its production, while at the same time guaranteeing total sterility of the assembly.

Advanced ampoule for hypodermic injections

System and approaches for sterilizing a drug delivery device

Patent FR1038330A

Patent FR2245382A1

Disposable two-compartment syringe

DISPOSABLE TWO-COMPARTMENT SYRINGE Abstract of the Disclosure A prefilled, readily activated disposable syringe wherein a fluid medicament is sealed in a syringe barrel by means of a puncturable sealing element. The syringe barrel also accommodates a slidable piercing member which includes a piercing tubular member held out of contact with the punc-turable sealing element until it is desired to intermix a second fluid material with the first. The slidable piercing member has a removable cap disposed thereon for sterile thumb contact and engagement means between the slidable member and the sealing element so that the slidable piercing member pos-itively engages and pierces through the puncturable sealing element when it is desired to activate the syringe A stop-pered vial containing the second fluid is also pierced by the piercing tubular member and upon movement of the vial toward the punctured sealing element quick and efficient mixing of the two fluid materials is effected as well as administration of the combined materials.

Injection cartridge and injection apparatus comprising the same

본 발명은 약물 주입 카트리지 및 이를 포함하는 약물 주입기로, 바늘부(10)와 카트리지(20) 사이에 밀림방지부(100)를 형성하여 카트리지(20)에 가해지는 압력에 의해 고무막이 팽창되는 것을 방지하여 약물이 누수 되지 않아 약물 주입 정밀도가 향상될 수 있다. The present invention is a drug injection cartridge and a drug injector including the same, by forming the anti-skid part 100 between the needle part 10 and the cartridge 20 so that the rubber film is expanded by the pressure applied to the cartridge 20 By preventing the drug from leaking, the precision of drug injection can be improved.

Hypodermic devices

A cartridge for use in a medication dispensing device

본 발명은 다중 격벽을 포함하는 약품 분배 장치용 카트리지에 관한 것이다. 카트리지는 본체와, 본체의 내부 표면과 유체 기밀식으로 결합하는 축방향 이동가능한 격벽을 포함한다. 제1 격벽은 기단 위치에서 본체의 내부 중공부로 개방되는 분배 포트를 덮는다. 제2 격벽은 내부 중공부로 개방되는 충전 포트를 덮는다. 제1 격벽은 장치의 분배 작동 중에 내부 중공부와 유체 연통하기 위하여 축방향에 대체로 수직하게 이동하는 분배 도관에 의해 결합되도록 배열된다. 제2 격벽은 카트리지의 충전 중에 내부 중공부와 유체 연통하기 위하여 충전 도관에 의해 결합되도록 배열된다. 약품 분배 장치, 카트리지, 격벽, 충전 포트, 분배 포트 The present invention relates to a cartridge for a drug delivery device including multiple partitions. The cartridge includes a body and an axially movable partition that fluidly engages the interior surface of the body. The first partition wall covers the dispensing port which opens to the inner hollow of the body at the proximal position. The second partition wall covers the filling port which opens to the inner hollow part. The first partition is arranged to be joined by a dispensing conduit that moves generally perpendicular to the axial direction in fluid communication with the inner hollow during dispensing operation of the device. The second partition is arranged to be joined by the filling conduit to be in fluid communication with the inner hollow during filling of the cartridge. Chemical dispenser, cartridge, bulkhead, filling port, dispensing port

Administration Assembly for a Medicament Delivery Device

The present disclosure relates to a administration assembly for a medicament delivery device, comprising: an elongated tubular delivery member cover (7), a cartridge holder (11) configured to be received by the delivery member cover (7) and configured to accommodate a medicament cartridge (31), the cartridge holder (11) having a radially flexible and radially inwards extending cartridge blocking protrusion (11b) configured to prevent the medicament cartridge (31) from moving proximally until being subjected to a proximally directed force larger than a threshold value, a needle assembly (13) comprising a double-edged needle having a proximally extending needle portion (13a) and a distally extending needle portion (13b), wherein the needle assembly (13) is configured to be assembled with the cartridge holder (11) so that the distally extending needle portion (13b) extends into the cartridge holder (11), and an administration mechanism including a plunger rod (27) configured to be proximally biased, wherein the delivery member cover (7) is configured to be linearly displaced in the distal direction relative to the cartridge holder (11), and wherein the delivery member cover (7) is configured to activate the administration mechanism when moved in the distal direction, causing the administration mechanism to move the cartridge holder (11) in the proximal direction and to subsequently move the plunger rod (27) in the proximal direction inside the cartridge holder (11) with a force larger than the threshold value.

Device for extracting a fluid from an ampoule

A device for extracting a fluid from an ampoule, comprising a plunger body (2) arranged for enclosing an ampoule (3) and a syringe body (4) movable relative to the plunger body (2). The syringe body (4) comprises a piston member (6) and an outer tubular casing (8) concentrically arranged around the piston member (6). The piston member (6) comprises an insertion end (10), receivable within the plunger body (2) and arranged for insertion in the ampoule (3), an ejection end (12) attached to the outer tubular casing (8), and a lumen (14) extending between the insertion end (10) and the ejection end (12). The plunger body (2) and the syringe body (4) form an actuating arrangement of the device (1) arranged to move the piston member (6) through the ampoule (3) during operation and forcing a fluid from the ampoule (3) through the lumen (14).

Botulinum toxin prefilled syringe system

本发明涉及一种具有所期望注射力特征，特别是低滑动力和低松脱力的肉毒杆菌毒素预填充式注射器系统，其包括一容纳有液态肉毒杆菌毒素组合物的玻璃注射器套筒、一柱塞挡止器以及一封闭装置(例如一尖端盖或一针罩)。此外，本发明涉及一种套组，其包括所述肉毒杆菌毒素预填充式注射器系统并且任选地包括使用说明书，以及涉及一种肉毒杆菌预填充式注射器系统在治疗和美容应用中的用途。

Ampule-container medical syringe and methods

A medical syringe has a plunger bore (1 and 2) that is flexible. A hermetically-sealed glass ampule (3) containing a drug in the form of a liquid referred to generally as a sterile preparation (4) is placed in the plunger bore (1 and 2). When the plunger (1) is pulled outwardly a select distance to expose the flexible plunger bore (2), the glass ampule (3) is broken by hand-squeezing the plunger bore (2) against it. Liquid preparation (4) from the glass ampule (3) is directed through a check-valved orifice (16) at a tip of a resilient piston section (21) of the plunger (1). At the check-valved orifice (16), the preparation (4) enters into a syringe bore (6). There the preparation (4) can be injected through a conventional luer (38-40) and hypodermic needle (37) by the standard practice of depressing the plunger (1) into the syringe (7). Variations are provided for storing ampules of preparation either in or separately from the syringe. Embodiments are described for various adaptations. Use methods are described.

Medicament delivery device

A medicament delivery device is provided. The medicament delivery device may include, among other features, a cartridge holder mounted in a housing and configured to receive a cartridge containing a medicament. The device may also include an outer cap detachably connected to the housing, and a coupling mechanism configured to connect the outer cap to an injection needle holder to which an injection needle is fixed. The coupling mechanism may include a rotatable member configured to be connected to an injection needle holder. The coupling mechanism may also be threadedly engaged with, and rotatable to, the outer cap. The configuration of the device may allow for quicker and more efficient delivery of medicament.

Medicament injection device

A medicament injection device comprising: a main body configured to receive a medicament cartridge, a needle sleeve axially movable with respect to the main body, a needle holder holding a needle, and a displacement element coupled to the needle holder and disengageably coupled to the needle sleeve; wherein, upon axial displacement of the needle sleeve by a predefined distance in a proximal direction, the needle carrier and needle are displaced axially in a proximal direction.

HYPODERMIC SYRINGE

a. Seringue comprenant une ampoule et une aiguille hypodermique. b. L'ampoule est fabriquée suivant une technique de moulage par injection et soufflage et la seringue utilise différentes formes d'obturateurs hermétiques destinés à assurer la stérilité du médicament c. Seringues à jeter. at. Syringe comprising an ampoule and a hypodermic needle. b. The ampoule is made using an injection blow molding technique and the syringe uses different forms of hermetic seals to ensure sterility of the drug c. Disposable syringes.

Botulinum toxin prefilled syringe system

The present invention relates a botulinum toxin prefilled syringe system with desirable injection force characteristics, in particular low gliding force and low break loose force, comprising a syringe barrel of glass containing a liquid botulinum toxin composition, a plunger stopper and a closure device such as a tip cap or a needle shield. In addition, the present invention relates to a kit comprising the botulinum toxin prefilled syringe system, and optionally instructions for use, and to the use of the botulinum toxin prefilled syringe system in therapeutic and cosmetic applications

Large capacity syringe

Device and method for storing and mixing bone cement

One aspect relates to a device for mixing a polymethyl methacrylate bone cement formed of two starting components and for storing the starting components of the bone cement. The device has a tubular cartridge with a cylindrical interior. A powder is contained in a front of the cartridge and a container containing a monomer liquid is arranged in a rear of the cartridge. A discharge piston is arranged between the container and the powder, and a conveying piston is on the side of the container opposite the discharge piston. The discharge piston and the conveying piston are arranged in the interior of the cartridge movably in the longitudinal direction. A conduit is provided that connects the front part and the rear part of the interior of the cartridge to one another in a manner permeable for the monomer liquid and for gases and which is impermeable for the powder.

Multi-outlet medical dispensing device

Ingestible device with delivery member detachment

公开一种适于吞咽到患者的胃肠道内腔中的可摄取装置，所述内腔具有内腔壁。可摄取装置(100、200)包括：胶囊(110、120)；递送构件(130)，所述递送构件被成形为穿透内腔壁的组织，并且具有组织穿透端和尾端，所述递送构件(130)包括治疗有效载荷；相对于所述递送构件(130)附接在所述尾端处的压头(150)；和致动器(140)，所述致动器联接到所述压头(150)并且具有第一配置和第二配置，所述递送构件(130)在所述致动器(140)处于所述第一配置时由所述压头(150)保持在所述胶囊(110、120)内，其中所述递送构件(130)被配置成通过致动器(140)从第一配置移动到第二配置从所述胶囊(110、120)推进并进入到内腔壁中，使得递送构件(130)沿着预定义轨迹移动。所述压头(150)被配置成在致动器(140)移动到所述第二配置中时相对于所述预定义轨迹倾斜以从所述压头(150)脱离递送构件(130)的至少一部分，使得所述递送构件(130)的脱离部分保持在内腔壁内以释放治疗有效载荷。

Capsule needle

一种胶囊针，由胶囊针盖、胶囊和胶囊盖组成，其特点在于：胶囊一端设有针头，另一端标有容量。胶囊针盖盖在胶囊前半端，胶囊盖盖在胶囊后半段，胶囊针盖和胶囊盖将胶囊包在其中。所诉胶囊盖，设有不同颜色，代表胶囊的容量不同，方便患者识别胶囊的容量。

Prefilled two compartment syringe

Bone cement applicator with bony cement driven closure system

Die Erfindung betrifft einen Knochenzementapplikator zum Mischen und Applizieren eines Knochenzements, bei dem die Ausgangskomponenten (1, 2) des Knochenzements in einer geschlossenen Kartusche (3, 4) zu einem Knochenzementteig (44) mischbar sind, wobei die Kartusche (3, 4) ein mehrteiliges Verschlusssystem umfassend eine Austragsöffnung aufweist, wobei zumindest zwei Teile (7, 8) des Verschlusssystems angetrieben durch eine Bewegung des gemischten Knochenzementteigs (44) gegeneinander bewegbar sind und sich durch diese Bewegung der zumindest zwei Teile (7, 8) des Verschlusssystems gegeneinander die Austragsöffnung öffnet, und wobei die Bewegung des gemischten Knochenzementteigs (44) durch einen Druck auf den Knochenzementteig (44) anzutreiben ist.Die Erfindung betrifft auch Verfahren zur Vermischung der Ausgangskomponenten (1, 2).

SYRINGE