ИГОЛЬЧАТАЯ КАНЮЛЯ, СПОСОБ ИЗГОТОВЛЕНИЯ ИГОЛЬЧАТОЙКАНЮЛИ И ИСПОЛЬЗОВАНИЕ ИГОЛЬЧАТОЙ КАНЮЛИ

Изобретение относится к медицинской технике, а именно к игольчатым канюлям для инъекции жидкого лекарственного препарата в тело человека. Комплект иглы для инъекции содержит игольчатую канюлю и втулку. Канюля выполнена с полостью, проходящей через нее от прокалывающего кожу дистального конца до противоположного проксимального конца вдоль продольной оси указанной игольчатой канюли. Продольная полость выполнена цилиндрической и имеет по существу один и тот же постоянный внутренний диаметр по всей длине указанной игольчатой канюли. Канюля имеет первый удлиненный участок, выполненный снаружи сужающимся на конус, по меньшей мере, на части длины до прокалывающего кожу дистального конца, и имеет второй удлиненный участок игольчатой канюли с наружным диаметром, равным или больше, чем наибольший диаметр первого удлиненного участка. Втулка имеет основание и кольцевую гильзу, проходящую от основания. Кольцевая гильза имеет средство для закрепления, выполненное с возможностью отсоединения указанной ...

УСТРОЙСТВО ДЛЯ СУБРЕТИНАЛЬНОГО ВВЕДЕНИЯ ТЕРАПЕВТИЧЕСКОГО СРЕДСТВА ИЗОГНУТОЙ ИГЛОЙ

Группа изобретений относится к медицине. Устройство включает в себя корпус, канюлю и иглу. Канюля является гибкой и продолжается в дистальном направлении из корпуса. Игла выполнена с возможностью скольжения в канюле. Игла содержит острый дистальный наконечник и изогнутый участок. Игла выполнена с возможностью поступательного перемещения относительно канюли между проксимальным положением и дистальным положением. Дистальный наконечник выполнен с возможностью расположения внутри канюли, когда игла находится в проксимальном положении. Дистальный наконечник выполнен с возможностью расположения снаружи канюли, когда игла находится в дистальном положении. Игла упруго отклоняется для продолжения по кривой на протяжении изогнутого участка. Применение данной группы изобретений позволит расширить арсенал технических средств. 3 н. и 16 з.п. ф-лы, 11 ил.

УСТРОЙСТВО ДЛЯ СУБРЕТИНАЛЬНОГО ВВЕДЕНИЯ ТЕРАПЕВТИЧЕСКОГО СРЕДСТВА ИЗОГНУТОЙ ИГЛОЙ

ПРЕДВАРИТЕЛЬНО ЗАПОЛНЕННЫЙ ПЛАСТИКОВЫЙ ШПРИЦ, СОДЕРЖАЩИЙ АНТАГОНИСТ VEGF

ЭМУЛЬСИИ ИЛИ МИКРОЭМУЛЬСИИ ДЛЯ ПРИМЕНЕНИЯ В ЭНДОСКОПИЧЕСКОЙ РЕЗЕКЦИИ СЛИЗИСТОЙ И/ИЛИ ЭНДОСКОПИЧЕСКОЙ ПОДСЛИЗИСТОЙ ДИССЕКЦИИ

Beidseitig beschichtete Spritzennadel

A hypodermic needle

Syringes

Variable pitch flexible needle

Syringe with integrally formed piercing member and luer slip.

Syringe with integrally formed piercing member and luer slip.

Syringe with integrally formed piercing member and luer slip.

SYRINGE

PLASTIC NEEDLE AND DEVICES WITH THIS

SAFETY PROTECTION FOR MEDICAL NEEDLES

INJEKTIONSNADEL AND LIQUID FLÜSSIGKEITSEINFÜHRENDES INSTRUMENT

INJEKTIONSNADEL

INJEKTIONSNADEL

INJECTION DEVICE AND DRIVE SYSTEM FOR IT

NEEDLE CANNULA

Low-drag septum for a catheter system

A peripheral intravenous catheter assembly may include a low-drag septum. The septum may include a body having a distal end and a proximal end, which may be sealed. The septum may include a slot disposed within an outer surface of the body and oriented along a longitudinal axis of the body. The slot may include a distal end spaced apart from the distal end of the body, and a proximal end spaced apart from the proximal end of the body. An introducer needle may extend through the slot.

Method for inserting a medical device flexible conduit into a user's target site

... - 16 METHOD FOR INSERTING A MEDICAL DEVICE FLEXIBLE CONDUIT INTO A USER'S TARGET SITE A method for inserting a medical device flexible conduit into a user's target 10 site includes adhering a medical device to a user with the medical device including a medical device flexible conduit and an insertion mechanism. Moreover, the medical device flexible conduit has an elongated Nitinol strip with a distal end, a proximal end, a longitudinal axis running from the distal end to the proximal end, a sharp head extending from the distal end, and a channel etched therein. In addition, the channel 15 is dispositioned along the longitudinal axis. The medical device flexible conduit also includes a flexible tube at least partially jacketing the elongated Nitinol strip between the distal end and the proximal end, the channel and flexible tube defining a conduit. The insertion mechanism is configured to insert a portion of the flexible conduit including the sharp head into a user's target site such that ...

Syringe needle assembly and medication injection device

To prevent a coating agent applied to the surface of a needle tube from infiltrating the space between a needle hub and the needle tube, a syringe needle assembly and medication injection device are equipped with a needle tube (5) that has a needle tip (5a) capable of puncturing a living body and is covered with a coating agent on the surface of the tip end at the needle tip (5a), and a needle hub (6) that holds the needle tube (5) in a such a way that the needle tip (5a) of needle tube (5) is projected. Furthermore, the needle hub (6) has a through hole (21) through which the needle tube (5) passes, and a discharge hole (23) that extends from the through hole (21) to the outer surface of the needle hub (6), and discharges any coating agent that infiltrates the inside of the through hole (21).

DEVICE FOR STAINING AN INTERIOR EYE STRUCTURE

NEEDLE WITH LATERAL APERTURE

Bruiseless cannula

A needle device (6) comprising a housing which can be mounted to an injection device (1). The housing comprises a first housing element (13) provided towards a proximal end of said needle device (6) and a second housing element (15) provided towards a distal end of said needle device (6). A cutting element (14) having a sharp proximal end is arranged at a proximal end of said first housing element (13). A cannula having a blunt proximal end (11) is fitted to the second housing element (15) and an opening for the cannula (11) is provided at the proximal end of the first housing element (13). The first housing element (13) and the second housing (15) element are moveable relative to each other between an extended position where the proximal end of the cannula (11) does not extend beyond the proximal end of the cutting element (14) and a compressed position where the cannula (11) extends through the opening of the first housing element (13) and past the proximal end of the cutting element ...

Vascular access device and guiding portion

According to various embodiments, a method and system to obtain access to a blood vessel underneath a skin layer that may preserve lifespan of the blood vessel and reduce executional skill variability may be provided. The method includes placing a guiding portion between the blood vessel and the skin layer; and configuring the guiding portion to receive and guide a needle to reach the same location of the blood vessel repeatedly and consistently; and forming a resultant scarred track between the blood vessel and the skin layer as the guiding portion is resorbed over time. The system includes a vascular access device configurable to first possess strength to penetrate through a tissue layer, subsequently possess flexibility to conform to the surrounding tissue beneath the tissue layer; and a guiding portion which may be resorbable, wherein the inlet includes a larger diameter compared to the outlet.

Coating agent and medical instrument surface treated with coating agent

The present invention provides a coating agent that has improved durability and a medical instrument (for example, a needle) that has been coated with said coating agent. This coating agent includes a hydroxyl-group-containing polyorganosiloxane (1) represented by general formula (1), a polydiorganosiloxane (2) represented by general formula (2), and an amino-group-containing polyorganosiloxane (3) represented by general formula (3). The mass ratio of the polydiorganosiloxane (2) to the amino-group-containing polyorganosiloxane (3) is 0.7-3.0. The hydroxyl-group-containing polyorganosiloxane (1) is included in a proportion of 2.4-5.5 mass% with respect to the total mass of the hydroxyl-group-containing polyorganosiloxane (1), the polydiorganosiloxane (2), and the amino-group-containing polyorganosiloxane (3).

Flow elements for use with flexible spinal needles, needle assemblies and methods for manufacture and use thereof

SURGICAL NEEDLE COATINGS AND METHODS

The present invention provides novel medical devices for use in surgical procedures and methods for manufacturing novel medical devices. In some embodiments, the novel medical devices can include surgical needles that are capable of being repeatedly passed through tissue using minimal force. More particularly, the surgical needles can be manufactured with one or more coatings that provide the surgical needles with both durability and lubricity for ease of repeated and successive passes through tissue. Novel methods for manufacturing the surgical needles and for providing and applying coatings to the surgical needles are also provided.

PEN NEEDLE ASSEMBLY WITH DIFFERENT GAUGE NEEDLE CANNULAS

A pen needle assembly is provided herein which includes: a hub having a body with a transverse wall; an arrangement, disposed on the hub proximally of the transverse wall, for mounting the hub onto an injector; a first needle cannula extending distally from the transverse wall, the first needle cannula terminating at a distal end, formed for insertion into a patient, with a first lumen extending proximally from the distal end, the first needle cannula being of a first gauge; and, a second needle cannula extending proximally from the transverse wall, the second needle cannula extending from a distal end and terminating at a proximal end with a second lumen extending distally from the proximal end. The first and second lumens are in communication. Further, the second needle cannula is of a second gauge, the second gauge defining a larger external cross-section than the first gauge. Advantageously, with the subject invention, two needle cannulas may be arranged in series of different gauges ...

METHOD AND APPARATUS FOR INDICATING OR COVERING A PERCUTANEOUS PUNCTURE SITE

Systems and methods are disclosed for identifying and deploying a protective cover about a percutaneous puncture site formed by a hypodermic needle (110). In the preferred embodiment, a marking agent or puncture site covering (102), the latter of which preferably takes the form of a bandage, is releasably secured upon either the needle hub of the hypodermic needle or on a sliding member or sleeve axially moveable along the length of said needle that forms a marking or detaches therefrom once compressed about the puncture site.

DEVICE FOR VENIPUNCTURE

SYRINGE PROTECTING DEVICE

A syringe protective device is provided with an outer cylinder body 4, an inner cylinder body 1, and a spring 3. When the spring 3 is released from a compressed state, the inner cylinder body 1 moves backward relative to the outer cylinder body 4 such that a syringe needle 202 is received within the outer cylinder body 4. The syringe protective device is provided with an unlockable pre-lock mechanism which affixes the inner cylinder body 1 to the outer cylinder body 4 while the spring 3 is maintained compressed in the front-rear direction. The pre-lock mechanism is configured so that the inner cylinder body 1 before being moved will be affixed to the outer cylinder body 4 by engaging the protrusion 22 of a ring body 2 with the engagement section of a through-groove section 42.

SYRINGE PROTECTING DEVICE

A syringe protecting device equipped with an outer cylinder (4), an inner cylinder (1) and a spring (3), wherein, when the spring (3) is released from its compressed state, the inner cylinder (1) is moved rearward with respect to the outer cylinder (4) so that a syringe needle (202) is stored inside the outer cylinder (4), and the syringe protecting device further equipped with a releasable pre-locking mechanism for fixing the inner cylinder (1) to the outer cylinder (4) while maintaining the spring (3) in the compressed state in the front-rear direction, wherein, the pre-locking mechanism fixes the inner cylinder (1) before movement to the outer cylinder (4) by engaging the protruding sections (22) of the ring (2) with the engaging sections of the through groove sections (42).

INJECTION DEVICE

The invention relates to a needle delivery device comprising a device body; one or more skin pinching members attached to the device body, the skin pinching members being moveable to pinch a longitudinal fold of skin of a patient. The device also comprises a drive mechanism configured to drive a needle out of the device body and along a needle path into the longitudinal fold of skin pinched between the pinching members, and subsequently withdraw the needle, the needle path extending substantially parallel to the surface of the patient.

COMPONENTS WITH HIGH API LOADING

Components with relatively high loading of active pharmaceutical ingredients are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent and a supporting material such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt% versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, Gl mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present ...

SELF-RIGHTING SYSTEMS AND RELATED COMPONENTS AND METHODS

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting ...

A SYRINGE

A SYRINGE

... ²²²A syringe (1) comprises a barrel (2) for containing a substance to be ²injected, a needle carrier (12) for carrying a needle (10), and a plunger (3) ²which is adapted to be movable in the barrel 2 to expel the substance to be ²injected from the needle (10). The plunger (3) has a first part (3a), a second ²part (3b) and a resilient member (6) therebetween, the first (3a) and second ²(3b) parts being adapted to be releasably locked together to hold the ²resilient member (6) in a compressed state. In use, the first part 3a of the ²plunger (3) and the needle carrier (12) are adapted to engage one another ²following expulsion of the substance, and the second part (3b) of the plunger ²(3) is adapted to be unlocked from the first part (3a) following said ²engagement, allowing the resilient member (6) to expand to propel the needle ²carrier (12) into the barrel (2).² ...

INTEGRATED CONDUIT INSERTION MEDICAL DEVICE

A medical device includes a medical device flexible conduit that has an elongated Nitinol strip with a distal end, a proximal end, a longitudinal axis running from the distal end to the proximal end, a sharp head extending from the distal end, and a channel etched therein. Moreover, the channel is dispositioned along the longitudinal axis. The medical device flexible conduit also has a flexible tube at least partially jacketing the elongated Nitinol strip between the distal end and the proximal end, with the channel and the flexible tube defining a conduit. The medical device also includes an insertion mechanism configured to insert a portion of the flexible conduit, including the sharp head, into a user's target site such that the conduit provides fluid communication to the target site.

DISPOSABLE NEEDLE AND HUB ASSEMBLY

DEVICES AND METHODS FOR INSTALLATION AND REMOVAL OF A NEEDLE TIP OF A NEEDLE

The present disclosure provides medical devices, particularly medical grade needles with removable tips, as well as methods of needle tip installation and removal, and devices therefor. Needle tip installation and removal devices may include needle tip installation and removal tools and kits, including hand held and manipulated tools that facilitate the installation and removal of needle tips, particularly on vascular access port needles. Such installation and removal devices may provide more expedient hook up of the access port for the therapy. Also, the installation and removal of the needle tips may be conducted in a more sterile manner.

EMULSIONS OR MICROEMULSIONS FOR USE IN ENDOSCOPIC MUCOSAL RESECTIONING AND/OR ENDOSCOPIC SUBMUCOSAL DISSECTION

The invention provides a pharmaceutical composition in form of emulsion or microemulsion for use in an endoscopic procedure, preferably said endoscopic procedure comprising the administration of said pharmaceutical composition to a human with the aim of improving and facilitating the resection of the lesion by raising the area where the lesion is located. The invention herein disclosed provides a method for performing an endoscopic procedure, said method preferably comprising the administration of a pharmaceutical composition in form of emulsion or microemulsion to a human. The invention herein disclosed also provides a kit for use in an endoscopic procedure, said kit comprising a pharmaceutical composition in form of emulsion or microemulsion, an endoscopic injection needle, a syringe and instructions for use thereof.

PIERCING MEMBER FOR CONTAINER ACCESS DEVICE

A device for transferring fluids includes a piercing member having a distal end and a proximal end and defines a longitudinal fluid channel. An opening is positioned at the distal end of the piercing member with the opening in fluid communication with the longitudinal fluid channel. Further, a sleeve having a proximal end and a distal end includes an extended position where the sleeve surrounds the piercing member and a retracted position where the sleeve is retracted from the distal end of the piercing member. The sleeve defines an opening at the distal end of the sleeve with a gap defined between the retractable sleeve and the piercing member.

LUBRICATED PEN NEEDLE

A pen needle (531) includes a hub (511) and a needle (513) fixedly connected to the hub (511). An outer cover (501) receives the hub (511). A lubricant reservoir (503) is disposed in the outer cover (501) such that a portion of the needle (513) is disposed in the lubricant reservoir (503) when the hub (511) is received by the outer cover (501). Lubrication of the needle (513) facilitates multiple injections.

METHOD AND RELATED DEVICES FOR MIXING TWO INJECTABLE COMPOSITIONS PRIOR TO INJECTION

This invention relates to a method for mixing a first injectable liquid pharmaceutical composition and a second injectable composition within an injection device, said injection device including: a generally cylindrical shell in which a cartridge is lodged or a generally cylindrical barrel, at one first end of the generally cylindrical barrel or the generally cylindrical shell, a plunger, the plunger being mounted on the barrel or shell, at a second end opposite the first end of the generally cylindrical barrel or the generally cylindrical shell, is provided a needle assembly support member, on which may be mounted a needle assembly, said needle assembly comprising means to be mounted on the needle support member, and further comprising: - at least one hollow cannula for transportation of liquid from the barrel or cartridge to the body of the patient; - and at least one hub surrounding part of the cannula and attached to cannula; said hub possibly including a hollow part; characterized ...

NEEDLE CANNULA CONTAINING MEDICAMENT

A method and system of delivering a first medicament to a first injection depth and a second medicament to a second injection depth using a single dispense interface. A medicated module (202, 500) is attachable to a drug delivery device (100), where the drug delivery device includes a drug reservoir (230) holding a first medicament (232). The medicated module includes a needle cannula (206, 400, 502) having a sidewall (314, 416), at least one micro-hole (308, 310, 312, 406, 410, 412, 414, 504, 506) in the sidewall of the needle cannula, and a flexible membrane (316) sealably fixed to an inner surface (318) of the needle cannula. The flexible membrane holds a second medicament (320, 420) between the flexible membrane and a portion of the sidewall having the at least one micro-hole. The first and second medicaments can be delivered to two, axially separate injection depths.

MEHRKAMMER-SPRITZAMPULLE.

Verfahren zur Herstellung scharfkantiger Metallgegenstände und nach dem Verfahren hergestellte Injektionsnadel

Surgical instrument i.e. injection needle, for patient, has instrument section insertable into patient body and provided with ultrasonic reflective coating on part of its outer surface, where section is formed in shape of shaft or cannula

The instrument (10) has an instrument section (18) insertable into a patient body and provided with an ultrasonic reflective coating (36') on a part of its outer surface. The section is formed in shape of a hollow shaft (20) or cannula, and has diameter in a range of o.5 mm to 5 mm. The coating is made of an electrically insulating material e.g. ceramic such as non-oxide ceramic, silicon carbide, boron nitride or mixed-oxide ceramic. The coating is comprised of yttrium, aluminum, boron, nitrogen, silicon, oxygen, silicon, carbon, diamond or zirconium.

УСТРОЙСТВО ЗАЩИТЫ ИГЛЫ

Изобретение относится к устройству защиты иглы для медицинских устройств, которое включает- основную часть, содержащую проходящий через неё канал, направленный в аксиальном направлении, для размещения в нём иглы; два противостоящих зажима, выходящих из основной части преимущественно в аксиальном направлении, каждый из которых содержит головную часть в области свободного конца, по меньшей мере одна из головных частей образует фиксирующее плечо для крепления устройства защиты иглы в корпусе медицинского устройства; эластичный элемент, окружающий зажимы в области между основной частью и головными частями. Конструкция эластичного элемента и зажимов позволяет раздвигать зажимы в стороны, противодействуя возвращающей силе эластичного элемента, что, в свою очередь, позволяет игле, находящейся в канале, полностью проходить через устройство защиты иглы. Также изобретение относится к игле для медицинского устройства и устройству внутривенного катетера, включающему иглу и устройство защиты иглы.

устройство защиты иглы для медицинских устройств и внутривенный катетер

Изобретение касается устройства защиты иглы для медицинских устройств, которое включает: - основную часть, которая содержит проходящий через нее канал, направленный в аксиальном направлении, для размещения в нем иглы; - два противоположных зажима, которые выходят из основной части преимущественно в аксиальном направлении, каждый из которых содержит главную часть в области свободного конца; по меньшей мере одна из главных частей образует фиксирующее плечо для крепления устройства защиты иглы в корпусе медицинского устройства, - эластичный элемент, который окружает зажимы в области между основной частью и главными частями. Конструкция эластичного элемента и зажимов позволяет раздвигать зажимы в стороны, противодействуя поворачивающей силе эластичного элемента, который в свою очередь позволяет игле, которая находится в канале, полностью проходить через устройство защиты иглы. Также изобретение относится к игле для медицинского устройства и устройству внутривенного катетера, который включает ...

液体注射针和液体注射装置

... 本发明涉及一种液体注射针(10)，该液体注射针(10)包括用于注射液体(8)的空心针部分(2)和该针部(2)固定于其上的支撑部分(3)。针部(2)包括贯穿所述支撑部分(3)内部的锚固部分(22)和从支撑部分(3)处延伸用于在活体上形成小孔的刺入部分(21)。刺入部分(21)具有大于或等于0.1mm并且小于或等于0.25mm的远侧面外径，以及大于远侧面外径的近侧面外径。 ...

INJECTION NEEDLE

Medical kit comprising an agent and an agent for treating a spinal disc

METHOD TO PRODUCE A CHARACTERISTIC IN A CANNULA.

DEVICE FOR DETERMINING THE CONCENTRATION OF A LEAST ONE SUBSTANCE IN LIVING TISSUE

DISPOSITIVO PARA DETERMINAR LA CONCENTRACION DE UNA SUSTANCIA QUE SE ENCUENTRA EN UN TEJIDO ORGANICO, COMO LA CONCENTRACION DE GLUCOSA, Y COMPRENDIDO POR UNA AGUJA SUBCUTANEA INTRODUCIBLE EN EL TEJIDO, HABIENDO UNA UNIDAD DE BOMBEO Y SUCCION PARA HACER LLEGAR UN LIQUIDO DE PERFUSION Y EVACUARLO DESPUES DE EQUILIBRARLO CON EL TEJIDO, DETERMINANDOSE EL GRADO DE INTERACCION DEL LIQUIDO DE PERFUSION CON EL TEJIDO A BASE DE PARAMETROS INDICATIVOS ENDOGENOS O EXOGENOS DEL LIQUIDO, Y UNA UNIDAD ANALIZADORA PROVISTO DE MEDIDORES DE CONCENTRACION DE LA SUSTANCIA Y DE LOS PARAMETROS INDICATIVOS, LA AGUJA SUBCUTANEA ES DE UN SOLO CONDUCTO DE FLUJO REVERSIBLE ACOPLABLE A LA ENTRADA DE LA UNIDAD ANALIZADORA, PRESENTANDO LA AGUJA UNA ABERTURA AL LADO DE SU PUNTA EN LA FORMA DE UNA HENDIJA EN SU PARED, ESTANDO LA SALIDA DE LA UNIDAD ANALIZADORA CONECTADA A LA UNIDAD DE BOMBEO Y SUCCION A TRAVES DE UNA VALVULA DE VARIOS PASOS, ESTANDO LA UNIDAD DE BOMBEO Y SUCCION CONECTADA POR UNO DE LOS PASOS C ON LA ...

dispositivo de segurança de agulha

APPARATUS FOR SUBRETINAL ADMINISTRATION OF THERAPEUTIC AGENT VIA A CURVED NEEDLE

AUTOMATIC EQUIPMENT FOR INJECTION

CANNULA WITH CONTROLLED DEPTH OF INSERTION

A cannula (24) for administration of a medicine to a target location (26) includes a tube 40 ()with at least one nodule (50) disposed along the circumferential surface (46) and spaced at a defined distance (54) from the distal end (42) of the tube (40). An arrangement (20) for delivery of a medicine to a target location (26) includes the cannula (24) and a pump (22) fluidly coupled to the cannula (24). The distal end (42) of the cannula (24) may be inserted into a target location (26) until the nodule (50) reaches a surface (46) that limits a depth of penetration before delivery of the medication.

GELS WITH PREDETERMINED CONDUCTIVITY USED IN IRREVERSIBLE ELECTROPORATION OF TISSUE

Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.

CANNULA FOR USE WITH A MEDICAL SYRINGE

A blunt needle plastic cannula for a syringe has a central axial passage terminating in a tip opening axially through one end thereof. Different axial sections along the cannula have respective differential resistances to movement relative to a membrane upon insertion of the cannula into the membrane. The opposite end of the cannula may have a Luer fit or Luer lock or may have integrally formed therewith an adapter for releasably connecting the adapter and cannula to the distal end of the barrel of the syringe.A syringe plunger and the adapter have connective structure whereby the adapter and cannual can be withdrawn into the interior of the barrel. The opposite ends of the barrel are sealed by portions of the plunger.

METHOD OF MAKING A NEEDLE AND A NEEDLE

A method is provided for forming a feature on a needle. In particular, a hollow, metal cannula has a first end, a second end and a substantially constant outer diameter extending over at least a portion of its length. An annular metal sleeve is provided that has a proximal shoulder and a distal shoulder. The length of the annular sleeve is less than the length of the constant diameter portion of the cannula. The sleeve has an inner diameter approximately equal to or less than the outer diameter of the constant diameter portion of the cannula. Two edges extend axially along the length of the sleeve, from the proximal shoulder to the distal shoulder, thereby defining a slit. The sleeve is positioned on the cannula at the constant outer diameter portion in an interference fit. An additional mechanical junction may be provided to secure the sleeve to the cannula. For example, the sleeve may be welded to the cannula using a laser welder at at least one edge of the sleeve near one of either the ...

AMPOULE HAVING AMPOULE HOLDER

The invention relates to an ampoule (40), comprising a cylindrical housing (48) having an outside diameter and a closure (41, 43, 44,), which closes a front of the housing (40), wherein the closure (41, 43, 44) protrudes radially over the outside diameter.

System including a tapered entry into an injection needle

An injection system comprising a tube having an inner diameter and an injection needle including a leading edge at one end thereof. A tapered surface is formed between a portion of the tube and the leading edge of the needle. The tapered surface provides a smooth transition surface from the tube to the needle, preventing the needle assembly from plugging when suspended particle materials are used in the injection system and allowing for easy and thorough cleaning of the needle for reuse and/or sterilization.

Spring cannulae

Disclosed herein are embodiments of spring cannulae, including one or more holes in the sidewall of the cannula. Some disclosed cannulae include a wire, helically wound to form coils, and at least one hole in the cannula that interrupts one or more of the coils. Some embodiments further include a fused region of the coils through which the hole passes. Some embodiments include a ring attached to ends of the interrupted coils, where the hole is surrounded by the ring. Some embodiments include a sheath that is attached to a radial surface of the interrupted coils, where the hole passes radially though the sheath.

Laminated sprinkler hypodermic needle

A laminated sprinkler needle for introduction of liquids into an animal and extraction of fluids from an animal comprising a substrate, a micromachined photoresist layer, and a microporous layer is described. The structure is of simple construction and fabrication and provides much higher flow rates than standard hollow cannula.

INTRAVENOUS THERAPY SYSTEM FOR BLOOD VESSEL ACCESS VIA A CURVED NEEDLE AND CURVED CATHETER

An intravenous therapy system may include a curved needle; and a curved catheter formed around the outside surface of the curved needle; wherein, upon insertion of a first length of the curved needle and curved catheter into a patient's body, a curvature angle of the curved needle and curved catheter causes the curved needle and curved catheter to intersect axially with a blood vessel in the patient's body.

DEVICES, SYSTEMS, AND METHODS FOR PROVIDING SURGICAL ACCESS AND FACILITATING CLOSURE OF SURGICAL ACCESS OPENINGS

A suture passer includes a handle, an elongated sleeve defining a distal end, an inner shaft slidably disposed within the elongated sleeve, and an end effector assembly disposed at a distal end of the inner shaft. The end effector assembly includes first and second arms, at least one which is movable relative to the other between a spaced-apart position and an approximated position for retaining a portion of a suture therebetween. The inner shaft and elongated sleeve are relatively movable between a first condition, wherein the first and second arms are disposed in the approximated position and the distal end of the elongated sleeve is exposed, a second condition, wherein the first and second arms are disposed in the approximated position and the distal end of the elongated sleeve is shielded, and a third condition, wherein the first and second arms are disposed in the spaced-apart position.

APPARATUS FOR SUBRETINAL ADMINISTRATION OF THERAPEUTIC AGENT VIA A CURVED NEEDLE

An apparatus includes a body, a cannula, and a needle. The cannula is flexible and extends distally from the body. The needle is slidably disposed in the cannula. The needle includes a sharp distal tip and a curved portion. The needle is configured to translate relative to the cannula between a proximal position and a distal position. The distal tip is configured to be positioned inside the cannula when the needle is in the proximal position. The distal tip is configured to be positioned outside the cannula when the needle is in the distal position. The needle is resiliently biased to extend along a curve through the curved portion.

AMPOULE WITH AMPOULE HOLDER

Measuring injection device

Die Erfindung betrifft eine messende Injektionsvorrichtung (1), insbesondere zur Injektion einer Insulinlösung und zum gleichzeitigen Messen eines Glucosewertes sowie ein Injektionssystem mit einer eine Messeinrichtung (23) aufweisenden Injektionsvorrichtung (1). Durch geschickte Ausbildung der Injektionsvorrichtung (1) lässt sich die Bedienbarkeit eines Gesamtsystems verbessern.

Injection device with sensor

An automatic injection device, especially for injection of insulin in the treatment of diabetes. The core of the invention is a sensor cannula. When this cannula punctures the skin the body fluid brings about an electrochemical influence on the sensor coating. Embodiments of the sensor cannula are proposed as active and passive components. A photometric sensor cannula is also described. The signal detected by the sensor cannula is fed to a computer for evaluation. The computer in turns controls a metering unit that releases the calculated dose for injection to a syringe barrel from a storage container. The invention is advantageous because the insulin injection can also be adjusted to suit the individual's lifestyle, measurement of the glucose concentration and injection of the required insulin dose are done via a single puncture and all other functions are essentially automatic. ...

NEEDLE SAFETY DEVICE AND ASSEMBLY

Safety IV catheter assemblies (IVCs) are disclosed herein comprising a needle hub with a needle (202) having a needle tip and a needle diameter, a catheter hub (102) with a catheter tube (112), and a tip protector or needle guard (44, 204) made from a first material comprising a proximal wall comprising an opening defining a bore (207) and two arms (206, 208) extending distally of the proximal wall, wherein at least one of the arms (206, 208) comprises an angled end section (214), and wherein an insert (404) made from a second material comprising an opening is aligned with the opening (207) of the proximal wall of the tip protector or needle guard (44, 204).

ИНЪЕКЦИОННОЕ УСТРОЙСТВО

Изобретение относится к медицинской технике, а именно к инъекционным устройствам для введения лекарственного средства. Устройство содержит: держатель картриджа, выполненный с возможностью размещения картриджа для лекарственных средств, полую инъекционную иглу, содержащую проксимальный конец, выполненный с возможностью прокалывания мембраны картриджа для установления сообщения по текучей среде между картриджем и иглой, колпачок, выполненный с возможностью расположения поверх держателя картриджа таким образом, чтобы закрывать иглу. При этом в исходном состоянии картридж расположен внутри держателя картриджа с мембраной, удаленной в осевом направлении от проксимального конца иглы, при этом колпачок приспособлен для перемещения иглы относительно мембраны для ее прокалывания при перемещении колпачка относительно держателя картриджа, причем одно или более боковых отверстий расположены в держателе картриджа, при этом колпачок содержит один или более внутренних продольных ребер, выполненных с возможностью ...

САМОУСТАНАВЛИВАЮЩИЕСЯ СИСТЕМЫ И СОПУТСТВУЮЩИЕ КОМПОНЕНТЫ И СПОСОБЫ

ПОКРЫТИЯ ДЛЯ ХИРУРГИЧЕСКИХ ИГЛ И СПОСОБЫ ИХ НАНЕСЕНИЯ

... 1. Хирургическая игла, содержащая:удлиненное тело, имеющее проникающий в ткань конец и конец для закрепления нити;нижнее покрытие, нанесенное на внешнюю поверхность удлиненного тела; иверхнее покрытие, которое отличается от нижнего покрытия, причем верхнее покрытие содержит силикон с высокими смазывающими свойствами, нанесенный на нижнее покрытие;причем нижнее покрытие связано с верхним покрытием.2. Хирургическая игла по п.1, в которой нижнее покрытие увеличивает долговечность верхнего покрытия.3. Хирургическая игла по п.1, в которой усилие, требуемое для проведения проникающего в ткань конца удлиненного тела через ткань, остается по существу постоянным после проведения проникающего в ткань конца через ткань по меньшей мере приблизительно тридцать раз.4. Хирургическая игла по п.1, в которой удлиненное тело выполнено из вольфрам-рениевого сплава.5. Хирургическая игла по п.4, дополнительно содержащая грунтовочное покрытие, нанесенное между внешней поверхностью удлиненного тела и нижним покрытием ...

НЕПОВРЕЖДАЮЩАЯ КАНЮЛЯ

... 1. Устройство (6) иглы для аппарата (100) для инъекций, содержащее:- корпус, который может быть установлен на аппарат (1) для инъекций, причем указанный корпус, содержит первый элемент (13) корпуса указанного устройства (6) иглы в направлении проксимального конца и второй элемент (15) корпуса в направлении дистального конца указанного устройства (6) иглы;- режущий элемент (14), расположенный на проксимальном конце указанного первого элемента корпуса (13), причем указанный режущий элемент (14) имеет острый проксимальный конец;- канюлю (11), установленную на втором элементе (15) корпуса, причем указанная канюля (11) имеет тупой проксимальный конец; и- отверстие для указанной канюли (11), предусмотренное на проксимальном конце первого элемента (13) корпуса;где первый элемент (13) корпуса и второй элемент (15) корпуса могут перемещаться относительно друг друга между выдвинутым положением и сжатым положением, при этом проксимальный конец канюли (11) не проходит за проксимальный конец режущего ...

Устройство для инъекции

Kanülenträger mit flexibler Kanüle

The invention relates to a cannula support which is connected to or which can be connected to a device for administering an injectable product. The cannula support comprises a) a housing (1, 2) with a through-channel (7) for the product, b) a piercing needle (3) which protrudes from a lower side of the housing (1, 2) in such a way that it can be inserted into tissue, c) and a flexible cannula (4) which surrounds the piercing needle and is connected to the through-channel (7) in order to convey the product between the piercing needle (3) and the cannula (4), d) wherein the flexible cannula (4) gives way in such a manner that it is expanded by the fluidic pressure of the product which is built up during administration.

VERFAHREN ZUR HERSTELLUNG VON EINEM MERKMAL AUF EINE KANÜLE

A syringe

Ophthalmic Injection device

An injection device comprising a valve disposed in a flow path between a reservoir 6 and a cannula 10, wherein the valve is normally closed when a force is applied to a plunger 7, and a valve actuation mechanism 14 to open a flow path through the valve, where progressive actuation of the valve actuation mechanism increases the flow rate of injection. The valve and its actuation mechanism may comprise a deformable valve seat 11, an elastomeric tube between two opposing surfaces, or sliding magnetic elements. The reservoir may comprise an insertable cartridge. There may be an elastically deformable tissue interface secured to the end of the cannula. The device can be used for controlled injections to subconjunctival, suprachoroidal or subretinal spaces of the eye.

VENIPUNCTURE DEVICE

... 1286789 Venipuncture device D W EDWARDS 19 April 1971 [24 July 1970] 24438/ 71 Heading A5R A venipuncture device for use in withdrawing a blood sample comprises a cannula 10 having a point 14 at an open end and a longitudinally-extending slot 22 extending from or spaced from the point 14, and a sleeve 44 which slides on the cannula 10 selectively to cover or expose the slot 22, the sleeve 44 forming a seal against the cannula 10. Sleeve 44 may also seal against the patient's skin 32 by means of a base 46 disposed at an oblique angle to the axis of the sleeve 44. The base 46 is preferably made of transparent material to facilitate positioning of the cannula over a vein 36, and may carry adhesive to improve the seal against the skin. In the embodiment shown, point 14 is at one side of the cannula 10 and the slot 22 is in the opposite side of the cannula 10, extending axially from the end opening. In a further embodiment, Fig. 5-7 (not shown) an additional axially-extending slot (24) is provided ...

Ophthalmic Injection device

NEEDLE TIP PROTECTION FOR SUBKUTANINJEKTIONEN

FLEXIBLE KANÜLE FROM A NITINOLSTREIFEN COVERED WITH A FLEXIBLE HOSE FOR MEDICAL APPLICATIONS

NEEDLE SAFETY DEVICE

AUTOMATIC INJECTION DEVICE AND - CARTRIDGE WITH NEEDLE.

DEVICE FOR THE DETERMINATION OF THE CONCENTRATION OF AT LEAST A IN ORGANIC FABRIC AVAILABLE SUBSTANCE.

NADELKANÜLE

Single-use syringe

METHOD AND APPARATUS FOR LOADING RADIOACTIVE NEEDLES

Injection needle

Retrobulbar needle and methods of use

A syringe and needle assembly includes a needle that extends through the barrel of the syringe and is attached to a proximal portion of the syringe. The distal end of the needle extends through a sleeve attached to the distal end of the syringe. The proximal end of the needle includes a spring which biases the needle proximally, so that the distal tip of the needle is normally retracted within the sleeve. The assembly can be used for injections in portions of a patient's body including delicate tissues that could be damaged if contacted by the needle tip

Medical device for glucose monitoring or regulation

A medical device comprising a pressure generating means adapted to displace a liquid, a sensor adapted to measure a flow resistance, and an implantable member comprising an analyte responsive porous membrane which reversibly changes its porosity subject to changes in analyte concentration occurring in the solution surrounding the implantable member. The analyte may in particular be glucose. The medical device may also be used for drug administration.

Medicated Module with Premix Medicament

A medicated module ( 4 ) for an injection system to co-deliver at least two medicaments ( 1, 2 ) is disclosed where a primary delivery device ( 7 ) contains a first drug agent and accepts a medicated module ( 4 ) containing a single dose of a secondary premix medicament ( 2 ) containing the first drug agent and at least a second drug agent, where both the primary medicament ( 1 ) and the secondary premix medicament ( 2 ) are delivered through a single hollow needle ( 3, 16, 21, 31 ).

Drug Delivery Device with Retractable Needle

Drug delivery device, comprising a needle, which a distal end and a proximal end comprises an inner surface forming a channel, an outer surface, a first salient located on the outer surface.

Seal Structures For Wet/Dry Automatic Injectors

An automatic injection device including a housing, a chamber with a first compartment and a second compartment, and a seal structure between the compartments. The seal structure is initially in a sealing condition that seals the first compartment from the second compartment, where the seal includes a plug and an outer sealing member. The plug is slidably movable within the outer sealing member to convert the seal structure from the sealing condition to a mixing condition by opening a path between the first compartment and the second compartment. The automatic injection device also includes a needle assembly and an activation assembly. Activation of the activation assembly causes (1) pressurization of the first compartment, (2) the seal structure to convert from the sealing condition to the mixing condition, and (3) the first and second medicament components to be mixed and forced through the needle assembly.

Medicated module with bypass and needle guard

A medicated module attachable to a drug delivery device comprises a connecting body configured for attachment to the drug delivery device. A first needle is fixed within the connecting body and a movable needle hub is operatively coupled to the connecting body. A needle guard is operatively coupled to the connecting body and a biasing member is positioned between the connecting body and needle guard. A second needle is fixed within the needle hub. A first cavity within the connecting body defines a reservoir containing at least one dose of a medicament. The reservoir configured for fluid communication with the first and the second needle. The reservoir comprises a bypass configured to allow medicament from the drug delivery device to bypass the reservoir and exit the second needle.

Integrated lancing device

A lancing device is provided that has a housing with a length greater than a width. Electronics are positioned in an interior of the housing. A test strip aperture is in the housing and is adapted to receive a body fluid test strip. A lancet aperture is positioned in line with the test strip aperture.

Drug delivery system, drug delivery device, needle assembly and method for priming

A drug delivery system comprises a drug delivery device which comprises a housing and a cartridge. The drug delivery device has a proximal end and a distal end. The drug delivery system further comprises a needle assembly which is attachable to the drug delivery device. The needle assembly and the drug delivery device are configured such that the cartridge is moved in the proximal direction with respect to the housing when the needle assembly is attached to the drug delivery device.

Safety Syringe Having A Manually Activated Retractable Needle

A retractable needle assembly includes a housing having a sidewall defining a hollow bore, and an elongate plunger, the distal end of the plunger forming a reservoir within the hollow bore for containing a fluid therein. The plunger is adapted for slideable movement within the hollow bore. The assembly includes a hub disposed within the hollow bore and at least partially supporting a cannula therewith, and a needle retraction member engaged with the hub for manually selectable advancement with respect to a portion of the housing. The needle retraction member may be advanced from an initial position in which at least a portion of the needle is disposed outside the housing, to a retracted position in which the needle is fully surrounded by the housing. The elongate plunger may be advanced about the hub for extracting the fluid into the reservoir or expelling the fluid from the reservoir.

Device and method for delivery of two or more drug agents

A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.

Rasping cannula

A rasping cannula uses a variety of cutting surfaces to augment fat and tissue extraction in cosmetic surgical procedures. In one aspect, a cannula may have a number of holes with curved cutting edges. In another aspect, the tip of a cannula may be curved. In this manner, lateral movement of the cannula excises tissue such as fat for faster, more effective removal.

Medicated module with dual safety guards

A medicated module for an injection system to co-deliver at least two medicaments is disclosed, where a drug delivery device containing a primary medicament accepts a medicated module containing a single dose of a second medicament and where both medicaments are delivered through a single hollow needle. The medicated module comprises two housings removably connected to each other, where each housing contains a sterile needle and needle needle guard assembly that locks out after the needle is inserted in an injection site.

HYPODERMIC NEEDLE ASSEMBLY HAVING A TRANSITION HUB FOR ENHANCING FLUID DYNAMICS AND MICROSPHERE INJECTABILITY

A hypodermic needle assembly and a method of delivering a microsphere drug. A hypodermic needle assembly includes an injection needle; an injection device; and a hub defining a cavity including a transition portion having a first end and a second end between the first end and an inlet of the injection needle and having a gradually decreasing diameter from the first end to the second end, wherein the hub is coupled between the injection needle and the injection device such that the first end is in fluidic communication with an outlet of the injection device and the second end is in fluidic communication with the inlet of the injection needle, wherein the diameter of the cavity at the first end is larger than an outlet diameter of the injection device, and wherein the diameter at the second end is substantially the same as an inlet diameter of the injection needle. 1. A hypodermic needle assembly comprising:an injection needle defining a passageway through the injection needle, the passageway having an inlet;an injection device defining a passageway through the injection device, the passageway having an outlet; anda hub defining a cavity in the hub, the cavity including a transition portion having a first end and a second end between the first end and the inlet of the passageway of the injection needle and having a gradually decreasing diameter from the first end to the second end, wherein the hub is coupled between the injection needle and the injection device such that the first end of the transition portion is in fluidic communication with the outlet of the passageway of the injection device and the second end of the transition portion is in fluidic communication with the inlet of the passageway of the injection needle,wherein the diameter of the cavity at the first end is larger than a diameter of the outlet of the passageway of the injection device, andwherein the diameter of the cavity at the second end is substantially the same as a diameter of the inlet of the ...

MEDICATED MODULE WITH LOCKABLE NEEDLE GUARD

A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament and where both medicaments are delivered through a single hollow needle. The medicated module is configured so that it will first deliver both the primary and secondary medicaments and then, if needed, a dose(s) of additional primary medicament. The module also contains a needle guard that locks the first dose delivery, but can be manually overridden by a user to perform a second or subsequent injection of primary medicament. 14. A medicated module attachable to a drug delivery device , wherein the drug delivery device comprises a primary reservoir of medicament and wherein the medicated module () comprises a second medicament , the medicated module further comprising:a. a reservoir containing the second medicament;b. a cavity containing the reservoir and a first and a second needle cannula, the first and second needle cannulae being configured to allow fluid communication with the reservoir,c. a needle guard to provide protection against at least one needle cannula arranged in a portion of the medicated module and configured to move in an axial direction during application to an injection site;d. a guard lock for at least temporarily disabling axial movement of the needle guard; ande. a release mechanism operably connected to the guard lock for unlocking the guard lock such that axial movement of the needle guard is enabled.2. The medicated module of claim 1 , where the release mechanism comprises a button accessible to a user to move the button to unlock the guard lock to enable axial movement of the needle guard.3. The medicated module of claim 1 , where the guard lock comprises a rotating sleeve operably connected to the needle guard.4. The medicated module of claim 1 , where the guard lock prevents the needle guard from moving ...

NEEDLE ASSEMBLY FOR MIXING OF SUBSTANCES

In one aspect of the invention, a needle assembly is provided, including: a body having a proximal end, a distal end, and a channel located therebetween, the body being configured to be mounted to an injector; a needle fixed to the body, the needle having proximal and distal ends, the distal end extending distally from the distal end of the body and being formed for insertion into a patient, the proximal end of the needle being in communication with the channel; and, a filter disposed in the channel proximally of the proximal end of the needle. Advantageously, a needle assembly is provided which permits mixing of at least two substances in preparation for injection, without modification to the associated injector. 1. A needle assembly comprising:a body having a proximal end, a distal end, and a channel located therebetween, said body being configured to be mounted to an injector;a needle fixed to said body, said needle having proximal and distal ends, said distal end extending distally from said distal end of said body and being formed for insertion into a patient, said proximal end of said needle being in communication with said channel; and,a filter disposed in the channel proximally of the proximal end of the needle.2. The needle assembly of claim 1 , further comprising a second filter disposed proximally of said filter in said channel.3. The needle assembly of claim 2 , wherein said second filter is more porous than said filter.4. The needle assembly of claim 1 , further comprising a shield to cover the distal end of the needle.5. The needle assembly of claim 1 , further comprising one or more mounting features to removably attach said body to an injector.6. The needle assembly of claim 5 , wherein the mounting features include one or more selected from the group consisting of: a luer arrangement claim 5 , a threaded arrangement claim 5 , and combinations thereof.7. The needle assembly of claim 1 , further comprising a second needle fixed to said body claim 1 , ...

SAFETY NEEDLE ASSEMBLY WITH CORRECT MEDICATION CONNECTION

An adapter is placed between the needle and a conventional fluid store, or medical line. The end of the adapter that connects to the needle assembly is formed to have a configuration that is complementary to that of the hub of the needle assembly, so that the adapter and the needle hub may be readily mated to each other. The other end of the adapter is formed to have another configuration, for example a conventional luer, that is readily connectable to a conventional fluid store, such as a syringe that has a conventional luer. The adapter is formed by inter-fitting two elements to effect an integral locking mechanism to prevent the uncoupling of the fluid store and the adapter, once they are securely coupled. 1. A needle hub comprising a one piece elongate cylindrical portion with an open end having an opening defined by a circumferential wall and a closed end , the open end forming a hub receptacle end having a particular formation that prevents the hub receptacle end from mating with a conventional luer end of a medical device , said particular formation including two protrusions formed at opposite sides of the hub receptacle end at a particular distance from the opening of the open end so that the protrusions are threadedly matable with an internal thread formed at an inner circumferential wall of a shroud having a complementary configuration to said particular formation , the hub receptacle end with the protrusions not matable with an internally threaded conventional luer end , said particular formation further including the circumferential wall of the elongate cylindrical portion being dimensioned to provide a given cross section for the opening at the hub receptacle end that prevents a conventional male receptacle end from being fittingly accepted into the opening.2. Needle hub of claim 1 , further having a needle extending from the closed end.3. Needle hub of claim 1 , wherein the shroud fits about a non-conventional receptacle end of a core claim 1 , and ...

SET FOR MEDICAL TREATMENT CONTAINING HOLDER FOR CANNULAS

Set for medical treatment by means of a pen-type holder containing a medical in solution for subkutan injection by means of a disposeable needle or cannula assembly engageable on one end of the pen. The set comprises at least one tubular holder () in which new or used cannulas can be inserted and stored the holder having firm fastening means () to be detachably adapted to the medical pen or other similar holders (). 110131013. Set for medical treatment by means of a pen-type holder containing a medical in solution for subkutan injection by means of a disposeable needle assembly or cannula engageable on one end of the pen , characterized in that the set comprises at least one tubular holder () in which cannulas can be inserted and stored , the holder having firm fastening means () to be detachable adapted to the medical pen or other similar holders () , the fastening means being formed as a clip () arranged to springy encircle the medical pen or other holders.2181917. Set according to claim 1 , characterized in that the holder is manufactured of two united tubular bodies ( claim 1 , ) to form a twin holder ().32101716. Set according to - claim 1 , characterized in that at the holder ( claim 1 , ) a tablet holder () for medicin in tablet form is arranged.4320212223. Set according to any of - claims 1 , characterized in that the holder () by means of a partition wall () is divided into two separate rooms ( claims 1 , ).541015. Set according to any of - claims 1 , characterized in that the holder () is provided with a pocket clip ().651210. Set according any of - claims 1 , characterized in that the cannula holder is provided with a score () so that the number of cannulas stored in the holder () can be read. The present invention relates to a set for medical treatment by means of a pen-type holder containing a medical in solution for subkutan injection by means of a disposable needle assembly or cannula engageable to one end of the pen.Diabetics depending of insulin and ...

Package for Delivering Microdoses of Medicament

A primary package for simultaneously dispensing microdoses of from 5 to 500 microliters of one medicament contained in a medicated module and another medicament contained in an attached injection system is disclosed, where the primary package contains a single dose of medicament contained within a reservoir cavity sealed with closure caps that secure top and bottom septa.

MULTI-CARTRIDGE FLUID DELIVERY DEVICE

A fluid delivery device for administering a first medicament and a second medicament includes a first fluid reservoir configured to contain the first medicament and a second fluid reservoir configured to contain the second medicament. The fluid delivery device may include one or more basal drive mechanisms to provide a basal delivery of one or more of the first and second medicaments. The fluid delivery device may further include one or more bolus drive mechanisms to provide a bolus delivery of one or more of the first and second medicaments. 1. A fluid delivery device for administering a first medicament and a second medicament comprising:a housing,a first reservoir within the housing and configured to contain the first medicament,a second reservoir within the housing and configured to contain the second medicament,and a needle having a first end configured for fluid communication with the first reservoir and a second end configured to extend exteriorly from the housing.2. The fluid delivery device of claim 1 , further comprising a basal drive mechanism for providing a basal delivery of the first medicament.3. The fluid delivery device of claim 2 , wherein the basal drive mechanism provides a basal delivery of the second medicament.4. The fluid delivery device of claim 2 , wherein the basal drive mechanism is a first basal drive mechanism and further comprising a second basal drive mechanism for providing a basal delivery of the second medicament.5. The fluid delivery device of claim 4 , wherein the first and second basal drive mechanisms each include a coil spring claim 4 , a basal drive piston claim 4 , and a hydraulic fluid reservoir.6. The fluid delivery device of claim 5 , further comprising a first pump chamber in fluid communication with the hydraulic fluid reservoir of the first basal drive mechanism via a first flow restrictor and a second pump chamber in fluid communication with the hydraulic fluid reservoir of the second basal drive mechanism via a ...

Medicated Module Having a Double Needle Guard

A medicated module () is attachable to a drug delivery device (). The medicated module () includes a housing () having a proximal end and a distal end, the proximal end has a connector () configured for attachment to a drug delivery device (). The distal end contains a shuttle (). A first needle () is fixed in the housing () and a second needle () is fixed in the shuttle (). The medicated module () also includes a reservoir () in the housing () comprising a medicament (). Further, the medicated module () includes a guard assembly () positioned in the housing () and configured to move in an axial direction during application to an injection site. Preferably, the medicated module () is locked out after at least two injections of the medicament () contained in the drug delivery device (). 1100. A medicated module attachable to a drug delivery device , wherein the drug delivery device comprises a primary reservoir of a first medicament and wherein the medicated module () comprises a second medicament , the medicated module comprising:a reservoir comprising the second medicament,a housing having a proximal end and a distal end, where the housing is being configured for attachment to the drug delivery device;a first needle fixed in the housing,a second needle fixed in a shuttle, wherein the shuttle is configured for axial movement relative to the housing,a trigger member configured to be axially moveable with respect to the housing, wherein the trigger member is configured to mechanically cooperate with the shuttle for moving the shuttle with respect to the housing,wherein a movement of the shuttle in axial direction opens fluid communication between the reservoir of the medicated module and at least one of the first and the second needle.2. The medicated module of claim 1 , wherein the reservoir of the medicated module is positioned within the housing by a first biasing member and a second biasing member.3. The medicated module of claim 2 , wherein the shuttle is ...

NEEDLE ASSEMBLY WITH RELEASE MECHANISM

A needle assembly comprises a body configured for attachment to a drug delivery device. The body defines a cavity. A septum is positioned within the cavity and a stopper positioned within the cavity such that the cavity, septum, and stopper define a reservoir. A double ended needle is positioned in the stopper and septum, the needle comprising a proximal end and a distal end. A release mechanism is positioned near a distal end of the body. A biasing element is positioned to drive the stopper. During a dose dispensing step, the release mechanism drives the proximal end of the needle out of the septum so that the proximal end resides in said reservoir. The biasing element may also drive the stopper proximally. 114-. (canceled)15. A needle assembly attachable to a drug delivery device , the needle assembly comprising:a main body, said main body defining a medicament cavity;a septum positioned within said cavity of said main body;a stopper positioned within said cavity such that said main body cavity, said septum and said stopper define a reservoir;a double ended needle positioned in said stopper and said septum, said double ended needle comprising a proximal end and a distal end;a release mechanism; anda biasing element positioned to drive said stopper;wherein, said release mechanism is configured to drive said proximal end of said needle out of said septum so that said proximal end resides in said reservoir, and said biasing element is configured to drive said stopper proximally.16. The needle assembly of claim 15 , further comprising a medicament contained within said reservoir of said needle assembly.17. The needle assembly of claim 16 , wherein said main body comprises a sealable opening and wherein the medicament is placeable into said reservoir by way of said sealable opening.18. The needle assembly of claim 16 , wherein said medicament comprises a GLP-1 claim 16 , a GLP-1 analog or a premix of insulin and a GLP.19. The needle assembly according to claim 15 , ...

Intravenous catheter set

The invention includes a barrel, a needle assembly, a catheter, a stopper and a vacuum generator. The needle assembly is disposed in the barrel and has a needle, a needle hub and a needle piston. The needle piston is fastened onto the needle hub. The catheter is axially connected onto the needle hub and passed through by the needle. The stopper is operably disposed at the first end of the barrel and normally stops the needle hub from moving. The vacuum generator has a plunger and a vacuum piston mounted on an end thereof. The vacuum piston is slidably received in the barrel and normally abuts against the needle piston, and the plunger protrudes from the second end of the barrel. The needle assembly will be pulled and retracted in the barrel when the plunger is pulled outward and the stopper releases the needle hub.

Medical Injection Device

The present invention relates to medicament injection devices (). A cartridge () with a septum and a needle unit () having front and rear needles () are configured for relative movement from a state where the septum is sealed to a state where the septum is pierced by the rear needle (). The injection device () may include a needle shield () and be configured for piercing the septum by the rear needle () when the front needle () is operated relative to the needle shield (). The injection device () may also include a damping mechanism configured for limiting the speed of movement of the cartridge relative to the needle unit. The injection device () may also include an indicator generating a signal when a piston driver has travelled the complete stroke length, wherein the indicator has a deflection element that is deflected prior to or during movement of the cartridge relative to the housing. 1. An injection device comprising:a medicament cartridge having an a cartridge septum adapted to be pierced by a needle for establishing fluid communication with the cartridge interior and having a slideably arranged piston which is driveable towards the cartridge septum,a piston driver capable of driving the piston towards the cartridge septum,a needle unit having a front needle for penetrating the skin of a subject user and a rear needle for piercing the cartridge septum, the front needle and rear needle being adapted for fluid communication, the cartridge and the rear needle being configured for relative movement from a first state where the cartridge septum is sealed to a second state where the cartridge septum is pierced by the rear needle,a needle shield associated with the needle unit, the needle shield and the front needle being configured for relative movement from a shielded state where the front needle is shielded into an unshielded state where the front needle protrudes from the needle shield, anda holding mechanism associated with to the needle unit and the cartridge ...

Neural injection system and related methods

A novel neural injection system and related methods are herein disclosed. Various embodiments of an embodiment of a neural injection system of the present invention provide for at least one benefit of enhanced injection characteristics, increased operational efficiency, reduced cost per unit, reduced incidence of injury through intraneural/intravascular injection, reduced incidence of injury through pricking/piercing, and/or the like.

Needle Cannula Containing Medicament

A method and system of delivering a first medicament to a first injection depth and a second medicament to a second injection depth using a single dispense interface. An example medicated module is attachable to a drug delivery device, where the drug delivery device includes a drug reservoir holding a first medicament. The medicated module includes a needle cannula having a sidewall, at least one micro-hole in the sidewall of the needle cannula, and a flexible membrane sealably fixed to an inner surface of the needle cannula. The flexible membrane holds a second medicament between the flexible membrane and a portion of the sidewall having the at least one micro-hole. The first and second medicaments can be delivered to two, axially separate injection depths. 1202500. A medicated module attachable to a drug delivery device , the drug delivery device having a drug reservoir holding a first medicament , the medicated module ( , ) comprising:a needle cannula having a sidewall;at least one micro-hole in the sidewall of the needle cannula;a flexible membrane sealably fixed to an inner surface of the needle cannula, wherein the flexible membrane holds a second medicament between the flexible membrane and a portion of the sidewall having the at least one micro-hole.2. The medicated module of claim 1 , wherein the second medicament is in direct fluid communication with the at least one micro-hole.3. The medicated module of claim 2 , wherein each micro-hole has a diameter of the at least one micro-hole is between 0.03 and 0.08 millimeters (mm).4. The medicated module of claim 1 , wherein claim 1 , after attachment to the drug delivery device claim 1 , the needle cannula is in fluid communication with the drug reservoir claim 1 ,wherein, during dispense, the first medicament flows through the needle cannula toward an output at a distal end of the needle cannula and compresses the flexible membrane against the sidewall, andwherein the flexible membrane forces the second ...

METHOD AND SYSTEM FOR PREVENTING LEAKAGE OF A MEDICAMENT

A system to prevent leakage of a medicament in a medicated module is disclosed. The medicated module includes a medicated needle that holds a medicament. The medicated needle includes an engagement needle portion and an output needle portion in fluid communication with each other. The medicated module further includes a first seal and a second seal. A proximal end of the engagement needle portion partially pierces the first seal, and a distal end of the output needle portion partially pierces the second seal. 114-. (canceled)15. A medicated module attachable to a drug delivery device , the medicated module comprising:a needle, wherein the needle holds a medicament, and wherein the needle includes an engagement needle portion and an output needle portion in fluid communication with each other;a first seal; anda second seal,wherein a proximal end of the engagement needle portion partially pierces the first seal, and wherein a distal end of the output needle portion partially pierces the second seal.16. The medicated module of claim 15 , wherein the first seal and the second seal each provide a fluid-tight seal that prevents leakage of the medicament.17. The medicated module of claim 15 , further comprising a needle cover claim 15 , wherein the needle cover comprises the second seal.18. The medicated module of claim 17 , wherein the second seal is positioned at a base of the needle cover.19. The medicated module of claim 15 , wherein during attachment of the medicated module to the drug delivery device claim 15 , a distal end of the drug delivery device forces the first seal in a distal direction claim 15 , wherein the engagement needle portion fully pierces the first seal.20. The medicated module of claim 17 , wherein the needle cover may be removed by a user claim 17 , and wherein claim 17 , after the needle cover is removed claim 17 , the second seal is removed from the distal end of the output needle portion.21. The medicated module of claim 15 , further comprising ...

Flush Syringe Having Compressible Plunger

An I.V. flush syringe assembly includes a barrel having an inside surface defining a chamber for retaining fluid, an open proximal end and a distal end with a passageway therethrough in fluid communication with the chamber. An elongate plunger having a proximal end, a distal end and a stopper is slidably positioned in fluid-tight engagement with the inside surface of the barrel for drawing fluid into and out of the chamber by movement of the stopper relative to the barrel. The plunger includes anti-reflux structure for minimizing stopper deflection when fluid has been delivered from the chamber and the stopper is being forced against the distal end of the chamber.

MEDICATED MODULE FOR A DRUG DELIVERY DEVICE

A method and system for dispensing a non-user settable dose of one medicament and a user-settable dose of a primary medicament. The system may include a medicated module attachable to a drug delivery device, the drug delivery device having a drug reservoir holding a first medicament. The medicated module includes a first needle, a second needle, a collapsible feature holding a second medicament, a biasing feature operably connected to the collapsible feature, and a valve system having a closed position and an open position. During dispense, the valve system transitions from the closed position to the open position, and the biasing feature compresses the collapsible feature to force the second medicament to flow from the collapsible feature to the second needle. 114-. (canceled)15. A medicated module attachable to a drug delivery device , the drug delivery device having a drug reservoir holding a first medicament , the medicated module comprising:a first needle;a second needle;a collapsible feature, wherein the collapsible feature holds a second medicament;a biasing feature operably connected to the collapsible feature; anda valve system comprising a flow channel, wherein the valve system has a closed position and an open position, wherein the valve system is in fluid communication with the first needle, wherein the valve system is in fluid communication with the collapsible feature, and wherein the flow channel is in fluid communication with the second needle,wherein, when the valve system is in the closed position, the valve system prevents fluid communication between (i) the second needle and the collapsible feature and (ii) the second needle and the first needle,wherein, during dispense the valve system transitions from the closed position to the open position, andwherein, when the valve system is in the open position, (i) the flow channel is in fluid communication with the collapsible feature and the first needle, and (ii) the biasing feature compresses the ...

DEVICE FOR THE RAPID INJECTION OF LOCAL ANESTHESIA THROUGH A PLEURALITY OF NEEDLES

This device is a compressible chamber designed to inject a liquid medication through a plurality of needles. It is a self-contained, rapidly deployed device that replaces a classic syringe. It consists of a shallow chamber that is closed on one end and sealed on the other with a sliding elastomeric seal. A rigid ring slides up into the chamber that has multiple small double-ended needles mounted through the periphery of the ring perpendicularly so as to be able to perforate the seal of the chamber with the proximal end and simultaneously penetrate the subcutaneous tissues with the distal end thus allowing medication to flow from the chamber into the tissues when pressure is applied to the top of the chamber. The needles are also imbedded in, or juxtapose to a ring of compressible dye-containing material that serves to conceal the needles and provide demarcation of the area injected. 1. A device for the injection of local medicine comprising:a chamber that is closed on the proximal end, open on the distal end and sealed by an elastomeric seal, where said chamber contains a liquid to be injected, with a base structure containing a plurality of needles and a compressible ring.240. A device according to further comprising having pressure placed on the top of the chamber forcing the base ring up inside of the chamber forcing the needles to penetrate the foam ring and force the moveable sealing ring into the chamber thus displacing the liquid through the needles.3. A device according to further comprising having said liquid injected into skin.4. A device according to further comprising having the foam strip contain a skin-marking dye.5. A device according to further comprising said the chamber and base having mating surfaces that would rotation before the liquid is injected.6. A device according to further comprising having said chamber be collapsible.7. A device according to further comprising having said liquid be liquid anesthesia.8. A device according to further ...

INLINE LIQUID DRUG MEDICAL DEVICE HAVING ROTARY FLOW CONTROL MEMBER

Inline liquid drug medical devices for use with a source of physiological fluid and a medicinal vessel for liquid drug reconstitution and administration purposes. The inline liquid drug medical devices include a housing having a longitudinal device axis, a rotary flow control member and a vial adapter for transposing the flow control member from an initial first flow control position for liquid drug reconstitution purposes to a second flow control position for liquid drug administration purposes. The inline liquid drug medical devices include a syringe port and a drug dispensing port co-axial with the device axis. The rotary flow control member is rotatable about an axis of rotation co-axial with the syringe port and the drug dispensing port. 1. An inline liquid drug medical device for use with a source of physiological solution and a medicinal vessel for reconstitution and administration of a liquid drug , the inline liquid drug medical device having a longitudinal device axis , and comprising:a) a housing including a first port for fluid connection with the source of physiological solution, and an integrally formed port manifold having a peripheral port manifold surface and a drug dispensing port for liquid drug administration, said first port and said drug dispensing port being co-axial with the device axis;b) a rotary flow control member having a second port and rotatable on said port manifold about an axis of rotation co-axial with the device axis, said first port and said drug dispensing port from an initial first flow control position for establishing flow communication between said first port and said second port for liquid drug reconstitution purposes to a subsequent second flow control position for establishing flow communication between said first port and said drug dispensing port for liquid drug administration purposes; andc) a manually rotatable vial adapter for snap fitting onto the medicinal vessel and including an elongated upright stem for initial ...

Medicament Delivery Device

Medicament delivery device comprising a housing () and container holder () accommodating a multi-chamber medicament container wherein said housing and said medicament container holder are interactively connected to and movable relative each other; a mixing guard mechanism interactively connected to the body for driving the medicament container holder within the housing achieving a reconstitution, wherein the mixing guard mechanism comprises a guard member (), a force member (), a guard member locking means () whereby, when the reconstitution is achieved, the medicament container holder and the guard member are movable in relation to said housing from a pre-mix position to a mixed position wherein said medicament container holder has been displaced distally in relation to said housing, at which mixed position said guard member locking means is activated, whereby said guard member is forced in the proximal direction by said force member for covering the delivery member (). 111-. (canceled)13. The medicament delivery device of claim 12 , wherein the first engagement members comprise resiliently movable hooking arms claim 12 , the second engagement members comprise a ledge claim 12 , and a proximal end surface of the housing is arranged to move the hooking arms out of engagement with the ledge when moved in contact with the hooking arms.14. The medicament delivery device of claim 12 , wherein the mixing guard mechanism comprises a first connection device interactively connecting the housing and the medicament container holder for allowing the medicament container holder to be displaced within the housing.15. The medicament delivery device of claim 14 , wherein the first connection device comprises cooperating threads on the housing and the medicament container.16. The medicament delivery device of claim 12 , further comprising a second guard member locking device interactively connected to the medicament container holder and to the guard member and configured to be ...

Medicated Module with Automatic Reservoir Engagement

A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle. The medicated module does not require the user to manually engage a reservoir containing the secondary medicament. Instead, a rotating housing automatically activates the reservoir when the needle guard is retracted. The needle guard prevents accidental needle sticks after an injection, and locks after dose delivery. 1. A medicated module attachable to a drug delivery device , comprising ,a) an outer housing having an inner surface, a proximal end and a distal end, where the proximal end has an upper hub having a connector configured for attachment to a drug delivery device;b) a bypass housing within the outer housing;c) a reservoir within the bypass housing comprising a single dose of a medicament;d) a lower hub holding a lower needle and an upper needle hub holding an upper needle;e) a needle guard having an inner wall and is slidably connected to the inner surface of the outer housing to prevent rotation of the needle guard when moved axially; and i. rotation of the rotating housing; and', 'ii. engagement of the lower needle with the reservoir to establish fluid communication with the medicament., 'f) a rotating housing having an internal surface and an external surface, where the external surface is engaged with the inner wall of the needle guard such that axially movement of the needle guard in the proximal direction causes,'}2. The medicated module of where the inner wall of the needle guard is in threaded engagement with the external surface of the rotating housing and the internal surface of the rotating housing is in threaded engagement with the lower and upper hubs such that the rotation of the rotating housing causes the upper hub to move distally and the ...

Hypodermic Needle With Multiple Dispersement Openings

A needle used for injecting viscous materials into a patient is provided. The needle would attach to a syringe. The needle end, although pointed, is blocked or stopped so that no fluid may exit. Along the barrel of the needle is a plurality of openings through which the viscous material or other medicament would be discharged into the patient. These openings may be circular, elliptical, square, rectangular or other geometric shapes. Certain sizes of the apertures and distance from one aperture to another are disclosed.

Therapeutic Material Delivery System for Tissue Voids and Cannulated Implants

Described herein is a novel drug delivery assembly having particular applicability to the field of orthopedic and surgical medicine. The devices and assemblies described herein enable the efficient application and retention of potentially expensive therapeutic materials to very specific locations, particularly those associated with voids in bone and tissue. One particularly unique aspect of the present invention involves the introduction of constructs which promote the retention of therapeutic material in the target area of application for beneficial use, for example by forming a proximal barrier that prevents leakage of the therapeutic material out of the target area. Additionally, the present invention provides unique devices and methods for surgical introduction of such constructs. The present invention finds particular application in connection with introduction of stem and progenitor cells, bioactive molecules and bone scaffold materials in conjunction with bone voids and with the use of cannulated implants, such as bone screws (also surgical screws) and pins. The present invention also has beneficial use in the delivery of cancer drugs, antimicrobials, bone cements and other therapeutic materials. 1. An assembly for delivering therapeutic material into a void in a tissue or implanted prosthetic device , said void accessed by means of a proximal opening , said assembly comprising:a. a flowable plug in a reservoir having distal and proximal ends and a linear axis extending therebetween;b. one or more fluid cannulated flow tubes having distal and proximal ends, wherein the proximal ends comprise an attachment point to a therapeutic fluid reservoir and the distal end comprises a therapeutic fluid discharge point; i. a plug reservoir cannula having proximal and distal ends and an axial bore extending therebetween, said bore comprising, in part, said plug reservoir, and wherein said proximal end comprises one or more flowable plug discharge ports serving as a path ...

Needle Assembly for the Delivery of at Least Two Medicaments

Various embodiments of needle assemblies for use with a drug delivery device to deliver two or more medicaments are provided. Additionally, various embodiments of methods for delivering two or medicaments are provided. In one embodiment, a needle assembly comprises an injection needle, a proximal housing member, a distal housing member, and a medicament transfer element. The proximal housing member contains a first medicament and is configured to attach to a drug delivery device containing a second medicament. The distal housing member is movably engaged with the proximal housing member such that relative axial movement between the proximal and distal housing members causes the first medicament to be delivered. Upon activation of the drug delivery device (e.g., activation of a dose button of the drug delivery device) the second medicament is transferred, via the medicament transfer feature, from the drug delivery device to the injection needle of the needle assembly such that the second medicament can be delivered.

THERAPEUTIC METHODS FOR SOLID DELIVERY

A fluid-delivery device includes an array of needles. The needle can deposit a hollow and/or porous tube into a tissue of a subject, and the porous tube can contain one or more fluid agents. The hollow and/or porous tube can control the rate at which the agents diffuse into the tissue. The device can simultaneously deliver a plurality of porous tubes along parallel axes in a tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue; based on the evaluation, candidate agents or subjects can be selected or deselected for clinical trials or therapy. 1. A drug-delivery device for constrained solid delivery of one or more fluid agents to a tissue , comprising:i) one or more needles each configured to receive a porous tube; andii) one or more porous tubes each configured to contain at least one fluid agent.2. The drug-delivery device of claim 1 , wherein at least one of said one or more porous tubes is biocompatible claim 1 , permeable claim 1 , and/or scissile.3. The drug-delivery device of claim 1 , wherein at least one of said one or more porous tubes comprises polysulfone claim 1 , polyamine claim 1 , polyamide claim 1 , polycarbonate claim 1 , polycarbamate claim 1 , polyurethane claim 1 , polyester claim 1 , polyether claim 1 , polyolefin claim 1 , polyaromatic claim 1 , polylactic acid claim 1 , a cross-linked polymer claim 1 , or a combination or co-polymer of any of the foregoing.4. The drug-delivery device of claim 1 , wherein at least one of said one or more porous tubes comprises polysulfone.5. The drug-delivery device of claim 1 , further comprising an actuator configured to push said one or more porous tubes from said one or more needles upon activation.6. The drug-delivery device of claim 5 , wherein said actuator is a plunger.7. The drug-delivery device of claim 1 , wherein each of said one or more needles is not permeable to said one or more fluid agents.8. The drug-delivery device of claim ...

MULTI-NEEDLE INJECTION DEVICE

A medical device and a method of treating stress urinary incontinence are provided. The device includes a cannula with a plurality of apertures. A plurality of needles is disposed within a lumen of the cannula. A handle includes a housing and a shifter mechanism to translate the plurality of needles from a first position in which the needles are disposed within the lumen of the cannula, to a second position in which a distal portion of each needle extends out of the lumen through respective apertures. The handle also includes a slot including a transversal track defining a potential range of rotational motion of the shifter mechanism with respect to the housing, and a plurality of longitudinal tracks defining a potential range of translational motion of the shifter mechanism with respect to the housing. The shifter mechanism may also rotate the cannula with respect to the handle. 1. A medical device comprising: a distal end portion;', 'a proximal end portion;', 'a lumen defined therethrough; and', 'a plurality of apertures disposed through the distal end portion to provide communication with the lumen;, 'an elongate cannula comprising a distal portion disposed in alignment with the plurality of apertures; and', 'a proximal end portion;, 'a plurality of injection needles disposed within the lumen, each comprising a housing configured to enclose a fluid volume;', 'a shifter mechanism coupled to the proximal end portion of the cannula and the proximal end portion of each of the plurality of needles, the shifter mechanism translatable with respect to the housing to translate the plurality of needles from a first position to a second position, the shifter mechanism rotatable with respect to the handle to rotate the cannula with respect to the handle;', 'a slot defined in the housing configured to receive a portion of the shifter mechanism therethrough, the slot comprising a transversal track and a plurality of longitudinal tracks, wherein the transversal track defines a ...

METHOD AND APPARATUS FOR PENETRATING TISSUE

A tissue penetrating system has a housing member. A plurality of penetrating members are positioned in the housing member. A tissue stabilizing member is coupled to the housing. A penetrating member sensor is coupled to the plurality of penetrating members. The penetrating member sensor is configured to provide information relative to a depth of penetration of a penetrating member through a skin surface. 1. A medicament delivery system , comprising:a housing member;one or more penetrating members positioned in the cartridge;a controllable driver configured to be coupled to the one or more penetrating members;a processor configured to be coupled to each of a penetrating member and the controllable driver, the processor customizing a user profile in response to user input information, the processor providing for localization of an injection of a medicament;a database that stores information for each user profile.2. The system of claim 1 , further comprising:a cartridge positionable in the housing member.3. The system of claim 1 , wherein the user profile is used to determine at least one of an amount of medicament delivered claim 1 , when a medicament is delivered claim 1 , and a phase of penetrating member movement for medicament deliver.4. The system of claim 1 , wherein the processor and controllable driver provide for targeted delivery of the medicament.5. The system of claim 1 , wherein the processor and controllable driver provide for an ability to accurately deliver medicament to a specific depth within a skin or tissue layer to minimize wastage of medicament.6. The system of claim 1 , wherein the processor and controllable driver provide for the ability to deliver a medicament to a precise depth.7. The system of claim 1 , further comprising:a feedback loop coupled to the processor and controllable driver.8. The system of claim 7 , wherein the feedback loop in operation provides for accurate control of medicament delivery.9. The system of claim 1 , further ...

Hand-held device for piercing a human or animal skin, and needle module

A hand-held device for piercing a human or animal skin, comprises a housing, a drive device, which is arranged in the housing and is suitable for repeatedly providing a feed motion. The device also comprises a piercing device, which is formed in the housing with a needle and is coupled directly or, via a coupling device, indirectly to the drive device in such a way that the feed motion provided by the drive device can be introduced onto the piercing device. There is a housing opening, relative to which the needle moves forwards and backwards during operation, and a piercing depth adjuster, which is coupled to the piercing device in such a way that the piercing depth adjuster is displaceable relative to the tip of the needle and is entrained with the needle as the needle moves forwards/backwards during operation.

TISSUE RESECTION DEVICE AND METHOD

Among other things, embodiments of devices (and parts thereof) are disclosed that can be used in treating Barrett's esophagus. Embodiments may have a suction cavity or window portion having elongated planar floor and ramped end surfaces with suction holes on one or both end surfaces. Examples include one or more fluid injection needles and parts for controlling fluid injection rate based on the rate of needle withdrawal. Embodiments can include one or more injection needles and receiving holes, with the ability to allow injectate to flow into tissue before withdrawing the needle(s), and/or lockout mechanism to prevent resection of tissue by a cutting mechanism prior to injection of fluid. Methods for treatment are also disclosed, and can include inserting a needle completely through tissue, and injecting fluid into tissue while withdrawing the needle back through the tissue, and/or injecting fluid into tissue while moving the needle forward through tissue. 1. A device for treating Barrett's esophagus , comprising:a shaft having a working end with a window portion for accepting mucosal tissue of a patient's esophagus, a suction lumen extending from a first proximal opening to the working end, and a guiding lumen extending from a second proximal opening to the working end, wherein the window portion includes a floor surface, oblique proximal and distal surfaces and side surfaces, a plurality of needles extending from or through the floor surface and a plurality of suction openings through the floor surface and connected to the suction lumen;a cutting mechanism passing through the shaft, the cutting mechanism including a cutting blade, a handle and a force transmitting portion, the force transmitting portion being movable through the shaft by operation of the handle, the cutting blade being movable through the window portion;a fluid injection system including a distal needle tip, a syringe, and a conduit connecting the syringe and the needle tip, wherein the syringe ...

MEDICAMENT RESERVOIR FOR A MEDICATED MODULE

A reservoir assembly for a medicated module includes a primary cavity for holding a medicament, a sump region, and a flexible element. The flexible element is configured to allow for fluid communication between the primary cavity and the sump region during a filling process for the reservoir. Further, the flexible element is configured to prevent fluid communication between the primary cavity and the sump region after the filling process. 116-. (canceled)17. A reservoir assembly for a medicated module , the reservoir comprising:a primary cavity for holding a medicament wherein the primary cavity is located along a central axis of the medicated module; a sump region, wherein the sump region comprises one or more cavities arranged around the primary cavity;a flexible element, wherein the flexible element is configured to allow for fluid communication between the primary cavity and the sump region during a pressure filling process for the reservoir assembly, and wherein the flexible element is configured to prevent fluid communication between the primary cavity and the sump region after the filling process, when the pressure is removed.18. The reservoir assembly of claim 17 , wherein the flexible element at least partially defines a vent path between the primary cavity and the sump region when the flexible element is deflected.19. The reservoir assembly of claim 18 , wherein the vent path allows air to flow from the primary cavity to the sump region during the filling process.20. The reservoir assembly of claim 17 , wherein the flexible element comprises a flexible primary-cavity bung.21. The reservoir assembly of claim 17 , wherein the flexible element comprises a vent valve.22. The reservoir assembly of claim 21 , further comprising at least one vent-valve channel between the primary cavity and the vent valve.23. The reservoir assembly of claim 17 , wherein the sump region comprises a sump-region vent channel.24. The reservoir assembly of claim 17 , further ...

Needle Assembly

A needle assembly has a needle hub that has a body to which are formed two plates at opposite sides thereof in a parallel relationship. The plates have respective upper edges and lower edges that lie substantially along respective planes, so that the needle hub may be stably placed onto a surface by means of the respective edges. A partition is formed orthogonally proximate to the front ends of the parallel plates. The partition and the parallel plates together provide upper and lower three point stable supports for the needle hub. A notch at the partition provides a guided line of sight to the tip of the needle for the user. The connector at the proximal portion of the needle hub has a non-conventional configuration that allows it to mate only with a counterpart special connector of a fluid conveying device that has a complementary non-conventional configuration. 1. A needle assembly , comprising:a hub extending along a longitudinal axis having an open proximal end and a closed distal end;a needle having a distal tip and an aperture at or proximate to the tip, the needle having a proximal end connected to the closed end of the hub to establish a through passage between the aperture of the needle and the open end of the hub;wherein the hub includes a proximal portion including the proximal end, the proximal portion having a non-conventional configuration that prevents it from coupling with a counterpart conventional connector having a conventional configuration but enables it to mate with a special connector having a counterpart configuration complementary to the non-conventional configuration; andwherein the hub further includes a distal portion having two plates positioned at opposite sides thereat in parallel to each other and a partition positioned orthogonal to and separating the two plates from the needle, the respective top edges and the respective bottom edges of the two plates being in correspondingly substantial co-planar alignment.2. Needle assembly of ...

INJECTION NEDDLE ASSEMBLY AND MEDICINE INJECTION DEVICE

A needle tube having a needle tip for puncturing skin; a needle hub; and a fluid-draining portion for enabling draining of a medicine. The needle hub includes: a retention part (first member) for retaining the needle tube; an insertion part into which the output portion of a syringe is inserted; and a flange-like skin contact portion that is disposed in a manner so as to cover an area surrounding the needle tube and makes contact with and/or faces the skin when a living body is punctured with the needle tube. The fluid-draining portion is disposed in the skin contact portion of the needle hub and enables a user to drain the medicine that has spilled when removing air and is held in the skin contact portion. 1. An injection needle assembly , comprising:a needle tube having a needle tip for puncturing the skin;a needle hub including: a front end part that retains the needle tube and from which the needle tip of the needle tube protrudes; an insertion part into which an output portion of a syringe is inserted; and a flange-like skin contact portion that is disposed so as to surround the front end part and that makes contact with and/or faces the skin when a living body is punctured with the needle tube; anda fluid-draining portion that is disposed in the skin contact portion of the needle hub and enables draining of a medicine staying in the skin contact portion.2. The injection needle assembly according to claim 1 , whereinthe fluid-draining portion is formed by coating the skin contact portion with a lubricant.3. The injection needle assembly according to claim 1 , whereina fluid-draining concave portion that is recessed toward the insertion part of the needle hub is formed in the fluid-draining portion, wherein the fluid-draining concave portion includes a sloped surface inclined upward from a bottom of the concave portion toward an edge of the skin contact portion.4. The injection needle assembly according to claim 3 , whereinthe concave portion is curved.5. The ...

Medicated module with automatic reservoir engagement and lock mechanism

A module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a module containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle. The module does not require the user to manually engage a reservoir containing the secondary medicament. Instead, a biasing member automatically activates the reservoir when the needle guard is retracted. The needle guard prevents accidental needle sticks before and after an injection, and locks after dose delivery. Restraining features are present on the module to prevent the needle guard from moving relative to the device, in a trigger locked position.

Needle Hub and Valve for Needle Hub

The invention is related to an apparatus comprising: a valve body comprising two inlet openings, one outlet opening and a central space connecting the inlet openings and the outlet opening, and a spherical element movably contained inside the central space configured for translatory movement and configured to seal either the first inlet opening or the second inlet opening, wherein each of the inlet openings are configured for fluid communication with a first reservoir and with a second reservoir and wherein the outlet opening is configured for fluid connection with a septum. This apparatus solves the object to make the exchange of used parts including the valve construction less complex. A further object of the invention is to make the exchange easier to handle. The invention is also related to a medical device comprising a dispense interface and an apparatus of the afore-mentioned type. 19-. (canceled)10. An apparatus comprising:a valve body comprising two inlet openings, one outlet opening and a central space connecting the inlet openings and the outlet opening, anda spherical element movably contained inside the central space configured for translatory movement and configured to seal either the first inlet opening or the second inlet opening,wherein each of the inlet openings are configured for fluid communication with a first reservoir and with a second reservoir andwherein the outlet opening is configured for fluid connection with a septum.11. The apparatus of claim 10 , wherein the spherical element is configured to be pressed against the first inlet opening claim 10 , while a pressure of a fluid in the second inlet opening is larger than the pressure of a fluid in the first inlet opening.12. The apparatus of claim 10 , wherein the spherical element comprises a core material and an outer material claim 10 , wherein the core material is harder than the outer material.13. A dispense interface configured for fluid communication with a first reservoir and a second ...

LOCK OUT MEMBER WITH DIFFERENT CROSS SECTIONS

An apparatus is presented comprising a lock out member configured to be implemented into a medical device, in particular a dispense interface, attachable to a second medical device, in particular a main body, wherein said lock out member is configured to prevent a second attachment of said medical device to said second medical device, wherein said lock out member has at least a first area with a first cross-sectional area, wherein said lock out member has at least a second area having a second cross-sectional area smaller than the first cross-sectional area, such that an electric resistance is defined between opposite ends of the lockout member and wherein said lock out member, at least in the second area, is made of a conductive material. 115-. (canceled)16. An apparatus , comprising:a lock out member configured to be implemented into a medical device, in particular a dispense interface, attachable to a second medical device, in particular a main body,wherein said lock out member is configured to prevent a second attachment of said medical device to said second medical device,wherein said lock out member has at least a first area with a first cross-sectional area andwherein said lock out member has at least a second area having a second cross-sectional area smaller than the first cross-sectional area,such that an electric resistance is defined between opposite ends of the lockout member, andwherein said lock out member, at least in the at least one second area, is made of a conductive material.1715. Apparatus according to claim , wherein said apparatus further comprises means configured to be conductively attached to a device , capable of measuring the resistance of at least said second area of said lock out member.1815. Apparatus according to claim , wherein said second cross section is at most 30% , in particular 20% , preferably 10% , of said first cross section.1915. Apparatus according to claim , wherein said lock out member is substantially made of metal.2015 ...

MEDICATED MODULE WITH LOCK FEATURE

A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle. The medicated module is initially in a locked state until attached to a drug delivery where interaction of the cartridge holder with the module bypass housing changes the module to a triggerable state. The medicated module does not require the user to manually engage a reservoir containing the secondary medicament. Instead, a biasing member automatically activates the reservoir when the needle guard is retracted when the module is in the triggerable state. The needle guard prevents accidental needle sticks before and after an injection, and locks after removal from the injection site. 128-. (canceled)29. A medicated module attachable to a drug delivery device , comprising ,an outer housing having a proximal end, a distal end, and an inner surface, where the proximal end has an upper hub and a connector configured for attachment to a drug delivery device;a bypass housing comprising an outer surface and a step down edge at a proximal end, wherein the bypass housing is located inside the outer housing and is configured to move both rotationally and axially relative thereto;a reservoir within the bypass housing comprising a medicament;a needle guard having inner and outer walls, wherein the inner wall is configured to engage the bypass housing to cause movement of the bypass housing, and wherein the needle guard outer wall is slidably engaged with the inner surface of the outer housing to prevent the needle guard from rotating during linear movement relative to the outer housing; anda biasing member engaged between the needle guard and a lower hub located at the distal end of the bypass housing, configured to bias the needle guard into an extended or guarded position; ...

MEDICAMENT INJECTION DEVICE

A medicament injection device includes a main body configured to receive a medicament cartridge sealed by a first penetrable barrier, a cap assembly including a button cap and a carrier unit, the button cap being rotatable with respect to the carrier unit and wherein the button cap is prevented from being displaced axially in a proximal direction unless the button is rotated into alignment with respect to the carrier unit, a needle carrier releasably coupled to the carrier unit, the needle carrier carrying a needle having a proximal end and a distal end, the needle carrier being releasably coupled to the push button. Subsequent to rotational alignment of the button cap with respect to the carrier unit, the button cap is axially displaceable in the proximal direction. Axial displacement of the button cap in the proximal direction causes the needle carrier to be displaced axially in the proximal direction. 1. A medicament injection device comprising:a main body configured to receive a medicament cartridge sealed by a first penetrable barrier;a cap assembly comprising a button cap and a carrier unit, wherein the button cap is dimensioned to fit over the carrier unit, the button cap being rotatable with respect to the carrier unit, and wherein the button cap is prevented from being displaced axially in a proximal direction unless the button cap is rotated into alignment with respect to the carrier unit; anda needle carrier carrying a needle having a proximal end and a distal end,wherein subsequent to rotational alignment of the button cap with respect to the carrier unit, the button cap is axially displaceable in the proximal direction,wherein an axial displacement of the button cap in the proximal direction causes the needle carrier to be displaced axially in the proximal direction, andwherein subsequent to the axial displacement of the button cap in the proximal direction, the button cap is separable from the main body and from the needle in a distal direction.2. The ...

INTEGRATED PAINLESS BONE MARROW BIOPSY DEVICE

An apparatus and method for performing painless bone marrow biopsy that requires only a single procedural pass to the biopsy bone site is disclosed. The biopsy device combines dermatotomy, anesthesia and marrow specimen extraction functionality and inherently aligns the bone drilling site with the site of anesthetic delivery by incorporating a transport channel that may be used for anesthetic delivery, into the biopsy needle used for bone access and bone marrow sample retrieval. The biopsy device also discloses a right angle drill interface and multiple side-access ports for aspiration and anesthetic syringe attachments. A novel syringe/plunger system comprising vacuum tube fitted plungers for quick transfer of marrow specimen sample without requiring a second non-sterile assistant is also disclosed. 1. A device comprising:a needle assembly comprising:a hollow tubular sleeve having a hollow opening therethrough,a stylet mounted in the hollow opening of the hollow tubular sleeve and having a first conduit therethrough, andone or more side openings,a liquid pressure generator in fluid communication with the first conduit and configured to apply pressure to liquid in the first conduit,wherein when a container containing a liquid anesthetic agent is in fluid communication with the first conduit and the liquid pressure generator applies pressure to the liquid anesthetic agent, the liquid anesthetic agent is forced through the first conduit and out through one or more end-openings of the stylet, andwherein when the device is inserted in bone marrow so that side openings are exposed to the bone marrow and a suction generator applies suction to a second conduit extending at least partway through the needle assembly, at least a portion of the bone marrow is withdrawn into the device through the side openings.2. The device of claim 1 , wherein the first conduit and second conduit are different conduits.3. The device of claim 1 , wherein the stylet includes a removable distal ...

CIPROFLOXACIN OTIC COMPOSITION AND KITS AND METHOD FOR USING SAME

Disclosed herein are otic product kits for administration of a sterilized formulation. In some embodiments, the otic product kit comprises: an aseptic container containing the sterilized formulation; a syring; and an administration needle connectable to the syringe, wherein the sterilized formulation comprising: from about 5.5 wt % to about 6.5 wt % multiparticulate ciprofloxacin; from about 15 wt % to about 17 wt % poloxamer 407; and water. Also disclosed herein are methods of preparing and administrating the sterilized formulation. In some embodiments, the method comprising (1) transferring the sterilized otic formulation from an aseptic container to a syringe through a preparation needle; (2) replacing the preparation needle with an administration needle; and (3) injecting the sterilized otic formulation from the syringe through the administration needle into the ear of a patient. 1. An otic product kit for administration of a sterlized formulation , comprising:an aseptic container containing the sterilized formulation;a syring; andan administration needle connectable to the syringe, wherein the sterilized formulation comprising: from about 5.5 wt % to about 6.5 wt % multiparticulate ciprofloxacin; from about 15 wt % to about 17 wt % poloxamer 407; and water.2. The otic product kit of claim 1 , wherein the aseptic container is sealed with a cap.3. The otic product kit of claim 2 , wherein the cap comprises a metal frame having a top wall and a side wall.4. The otic product kit of claim 3 , wherein the metal frame is made of aluminum.5. The otic product kit of claim 4 , wherein the cap further comprises a septum secured against the aseptic container by the aluminum frame.6. The otic product kit of claim 1 , wherein the administration needle is from 20 gauge to 24 gauge.7. The otic product kit of claim 1 , wherein the administration needle is flexible.8. The otic product kit of claim 1 , wherein the administration needle has a blunt tip.9. The otic product kit of ...

Fluid dispenser

A fluid dispensing device is provided for dispensing a measured amount of fluid into a living organism. The device includes a rigid fluid reservoir closed by a septum for use in a fluid dispensing device for dispensing a measured amount of fluid into a living organism, wherein the device has a main housing enclosing the operative components of the device, the said fluid reservoir located within the main housing, an injection assembly including a needle, and a trigger mechanism. The needle has a first end adapted to piercing the septum and pushing the septum into the reservoir so that the septum acts as a piston, expelling the fluid through the needle, and a second end adapted to injecting the fluid into the living organism.

Dual Syringe with Funnel Feeding Kit

The present invention is directed to multi-liquid loading and delivery kits comprising a first storage vessel for a first active component, a second storage vessel for a second active component, at least two transfer syringes, at least two vial adaptors, at least two cannulas with a through lumen and a multi-liquid delivery device. The delivery device has dual hollow cartridges, each with at least one throughbore at one end and plunger access at the opposing end, a kick stand, a removable dual feed funnel, a spray or drip manifold and at least one spray or drip tip assembly. 1. A multi-liquid loading and delivery kit comprising:a) A first storage vessel for a first active component;b) A second storage vessel for a second active component;c) At least two transfer syringes;d) At least two vial adaptors;e) At least two cannulas with a through lumen; and a. dual hollow cartridges, each with at least one throughbore at one end and plunger access at the opposing end;', 'b. a kick stand;', 'c. a removable dual feed funnel;', 'd. a spray manifold; and', 'e. at least one spray or drip tip assembly., 'f) a multi-liquid delivery device comprising'}2. The kit according to claim 1 , wherein each cannula is flexible and is provided with blunt non-traumatic end tip.3. The kit according to claim 1 , wherein the spray tip assembly comprises a spray cartridge with a dual path opening claim 1 , an interior mixing region claim 1 , an atomizing insert and flexible spray outlet cover.4. The kit according to claim 1 , wherein the drip tip assembly comprises a drip cartridge with a dual path opening in fluid communication via channels with a flexible drip outlet.5. The kit according to claim 1 , wherein the spray tip assembly is directly attached to the manifold.6. The kit according to or claim 1 , wherein the spray tip assembly is connected via a multi-lumen claim 1 , flexible tube to the spray manifold.7. The kit according to claim 1 , wherein the first and second active components are ...

Applicator for Dispensing a Medical Substance and Methods Associated Therewith

An applicator 270 includes a stem 174 having an axially-formed slot delivery passage 200. A slot 350 is formed transaxially through the stem 174 and is in communication with the slot delivery passage 200. An extended side wall 350b is formed on one side of the slot 350. A flat surface 354, which is formed in the stem 174, is spaced and extends angularly away from an opposite side of the slot 176 and from the extended side wall 350b to provide for direct and lateral dispensing of a cream 280 onto a tissue 242 of a patient.

Injection Needle Having Shield Activated Valve

The present invention relates to a needle assembly having a build-in valve (). The needle assembly is build up from a hub () carrying a needle cannula () and a telescopically movable shield () which axially covers the distal tip () of the needle cannula () be-tween injections. The valve () is operated by the shield () and is arranged such that it is closed when the distal tip () of the needle cannula () is covered by the shield () and is opened when the telescopically movable shield () has been retracted a specific distance (X) proximally to the distal tip () of the distal cannula part (). 1. A needle assembly having a build-in valve , comprising:{'b': '20', 'a hub carrying means for connecting the hub () to an injection device,'}a proximal cannula part for penetrating into a reservoir containing a liquid drug,a distal cannula part having a distal tip for penetrating the skin of an object, a first position wherein the shield axially covers the distal tip of the distal cannula part, and', 'a second position wherein the shield is axially retracted proximally to the distal tip of the distal cannula part,, 'a telescopically movable shield which is movable relatively to the hub betweena valve positioned between the proximal cannula part and the distal cannula part and which valve is closed when the telescopically movable shield is in the first position and open when the telescopically movable shield is in the second position.2. A needle assembly according to claim 1 , wherein the needle assembly is multiple usable.3. A needle assembly according to claim 1 , wherein the valve is opened when the telescopically movable shield has been retracted a specific distance proximally to the distal tip of the distal cannula part.4. A needle assembly according to claim 1 , wherein the distal cannula part and the proximal cannula part are separate cannulae.5. A needle assembly according to claim 4 , wherein the distal part and the proximal part are connected by a flexible tube.6. A ...

NEEDLE AND MANUFACTURING METHOD THEREOF

The present invention suppresses the formation of a pocket in a wall of a puncture route when a dull needle is moved forward along the puncture route. In order to achieve such aim, the invention provides a needle to be inserted into a puncture route extending from skin to a blood vessel under the skin to puncture the blood vessel, wherein: the needle is formed in a tubular shape and has an inclined end face at a tip of the needle, the inclined end face being inclined relative to an axis of the needle, a tip end of the inclined end face defining an unsharp edge; the needle has a flexibility of needle elastic modulus nE=1-900 Nmm as defined by an equation to be set forth below; a material of the needle is a resin; and the needle is manufactured by injection molding using a ring-shaped gate. 1. A needle to be inserted into a puncture route extending from skin to a blood vessel under the skin to puncture the blood vessel , wherein:the needle is formed in a tubular shape and has an inclined end face at a tip of the needle, the inclined end face being inclined relative to an axis of the needle, a tip end of the inclined end face defining an unsharp edge;the needle has a flexibility of needle elastic modulus nE=1-900 Nmm, as defined by an equation to be set forth below;a material of the needle is a resin; andthe needle is manufactured by injection molding using a ring-shaped gate, wherein{'sub': 2', '1', '2', '1, 'claim-text': [{'sub': '1', 'Mis a bending moment under a bending strain of 0.0005 in a three-point bending test;'}, {'sub': '2', 'Mis a bending moment under a bending strain of 0.0025 in the three-point bending test;'}, {'sub': '1', 'εis a bending strain of 0.0005; and'}, {'sub': '2', 'εis a bending strain of 0.0025.'}], 'the needle elastic modulus nE=(M−M)/(ε−ε), where2. A needle to be inserted into a puncture route extending from skin to a blood vessel under the skin to puncture the blood vessel , wherein:the needle is formed in a tubular shape and has an ...

MIXING PEN NEEDLE

An injection device is provided with dual medicament chambers and a mixing pen needle assembly, whereby predetermined dosages of two medicaments can be provided to a mixing reservoir in the pen needle assembly and delivered simultaneously with the injection device. 1. A medication pen comprising:a pen body having a distal end and a proximal end, and having a first medication compartment and a second medication compartment;first and second dosing mechanisms and first and second dosage plungers engaged in the respective first and second medication compartments;a movable housing received on the distal end of the pen body adapted to be received in first and second positions on the pen body;a pen needle assembly received on the distal end of the movable housing, said pen needle assembly comprising a patient end needle, a filler needle, and a collapsible mixing reservoir intermediate and accessed by said patient end needle and said filler needle;wherein the movable housing is movable between a first position in which the filler needle is in fluid communication with the first medication compartment and a second position in which the filler needle is in fluid communication with the second medication compartment; andwherein collapsing the mixing reservoir forces medication in the mixing reservoir through the patient end needle during an injection.2. The medication pen according to claim 1 , wherein each medication compartment comprises a medication cartridge and each dosage plunger engages a respective medication cartridge.3. The medication pen according to claim 1 , further comprising a check valve on the filler needle preventing backflow from the mixing reservoir into the first and second medication compartments.4. The medication pen according to claim 1 , wherein the first and second dosing mechanisms comprise first and second rotatable knobs protruding from the proximal end of the pen body.5. The medication pen according to claim 1 , wherein the movable housing is ...

METHOD AND APPARATUS FOR INJECTING A NEUROTOXIN INTO A LOCALIZED AREA

A syringe assembly for administration of a neurotoxin, the syringe assembly comprising: a syringe comprising: a clear syringe barrel with dosage markings completely encircling the clear syringe barrel; and a plunger having a plunger body and a clear inverted plunger tip; and a needle assembly comprising a needle and a sealing hub for removably attaching the needle assembly to the syringe, wherein the needle is approximately 0.15 inches to approximately 0.3 inches in length and has a gauge of approximately 27 gauge to approximately 35 gauge. 110.-. (canceled)11. A method for injecting a neurotoxin into a body of a patient , the method comprising: [ a clear syringe barrel with dosage markings completely encircling the clear syringe barrel; and', 'a plunger having a plunger body and a clear inverted plunger tip; and, 'a syringe comprising, 'a needle assembly comprising a needle and a sealing hub for removably attaching the needle assembly to the syringe;, 'providing a syringe assembly comprisingattaching a first needle assembly to the syringe assembly;passing the needle into a container of neurotoxin and drawing the neurotoxin into the syringe assembly;removing the first needle assembly from the syringe assembly;attaching a second needle assembly to the syringe assembly, wherein the needle of the second needle assembly is shorter and narrower than the needle of the first needle assembly; anddelivering the neurotoxin into the body of a patient.12. The method according to wherein the syringe is a 1.0 cc syringe.13. The method according to wherein the dosage markings are cc markings.14. The method according to wherein the dosage markings are unit markings.15. The method according to wherein the plunger body is clear.16. The method according to wherein the plunger body is opaque.17. The method according to wherein the needle is 0.25 inches in length.18. The method according to wherein the needle is 33 gauge.19. The method according to wherein a marker is disposed between ...

Injection Device

Described is an injection device (1) for administering a drug, the injection device (1) comprising a cartridge holder (2) adapted to receive a drug cartridge (3), a hollow injection needle (6) having a proximal tip (6.2) adapted to pierce a septum (4) of the cartridge (3) so as to establish a fluid communication between the cartridge (3) and the needle (6), and a cap (7) arrangeable over the cartridge holder (2) in a manner to cover the needle (6). In an initial state the cartridge (3) is arranged within the cartridge holder (2) with the septum (4) axially spaced from the proximal tip (6.2) of the needle (6). The cap (7) is adapted to move the needle (6) relative to the septum (4) for piercing it on movement of the cap (7) relative to the cartridge holder (2).

SURFACE HARDENED INJECTION NEEDLE AND METHOD OF PRODUCING SUCH

A medical injection needle () having a metallic needle body () comprising an axially extending wall (), a first end portion (), a second end portion (), and a flow path () providing for fluid communication between the first end portion () and the second end portion () along the axially extending wall (), wherein at least a portion of the metallic needle body () comprises a hardened surface layer () in which carbon atoms and nitrogen atoms are deposited. 2. A medical injection needle according to claim 1 , wherein the hardened surface layer has a radial extent (r claim 1 , r) which does not exceed 25 μm.3. A medical injection needle according to claim 1 , wherein the hardened surface layer has a radial extent (r claim 1 , r) which does not exceed 10 μm.4. A medical injection needle according to claim 1 , wherein the hardened surface layer comprises an inner layer in which predominantly carbon atoms are deposited and an outer layer in which predominantly nitrogen atoms are deposited.5. A medical injection needle according to claim 1 , wherein the at least a portion of the metallic needle body comprises the first end portion.6. A medical injection needle according to claim 1 , wherein the first end portion comprises a sharpened tip.7. A medical injection needle according to claim 1 , wherein the metallic needle body comprises a radially outwardly oriented surface and a radially inwardly oriented surface claim 1 , andwherein the hardened surface layer is present along at least a portion of at least one of the radially outwardly oriented surface and the radially inwardly oriented surface.8. A medical injection needle according to claim 7 , wherein the axially extending wall is tubular and has a thickness (t) in the range 25 μm to 50 μm.9. A medical injection needle according to claim 7 , wherein a first hardened surface layer is present along at least a portion of the radially outwardly oriented surface and a second hardened surface layer is present along at least a ...

CANNULA, AN INJECTION OR INFUSION DEVICE AND METHODS OF USING THE CANNULA OR THE INJECTION OR INFUSION DEVICE

The present invention provides a cannula () with a distal end () and a proximal end (), comprising a sidewall () defining a lumen () for receiving a fluid () from a feeding device (), wherein the sidewall () comprises a plurality of openings () for supplying the fluid () into a target tissue () of a patient. Each opening () is in fluid communication with the lumen () of the cannula (). Furthermore, an injection or infusion device () is provided, comprising said cannula () and a feeding device () for supplying the fluid () to the cannula (), wherein the cannula () is attached or is configured to be attachable to the feeding device (). Corresponding methods are also provided, using said cannula and/or said injection or infusion device (). 1300311312. A cannula () with a distal end () and a proximal end () , comprising:{'b': 301', '302', '800', '400', '500, 'a sidewall () defining a lumen () for receiving a fluid () from a feeding device (, ),'}{'b': 301', '303', '800', '700', '304', '302', '300, 'the sidewall () comprising a plurality of openings () for supplying the fluid () into a target tissue () of a patient, wherein each opening () is in fluid communication with the lumen () of the cannula ().'}25. The cannula according to any one of to or the injection or infusion device according to any one of to , wherein the fluid is a pharmaceutical composition comprising RNA.26. A method for delivering RNA to cells of a subject , comprising administering to the subject a fluid comprising the RNA using the cannula according to any one of to or or the injection or infusion device according to any one of to .27. A method for expressing RNA in cells of a target organ or tissue comprising introducing into the target organ or tissue a fluid comprising the RNA using the cannula according to any one of to or or the injection or infusion device according to any one of to .28. The method of claim 27 , wherein the RNA once introduced into the target organ or tissue is taken up by ...

AGENTS AND DEVICES FOR AFFECTING NERVE FUNCTION

Agents and devices for affecting nerve function are described. In some variations, a combination of agents, e.g., a cardiac glycoside, an ACE inhibitor, and an NSAID are delivered to affect nerve function. The agent may be delivered locally in a site-specific manner to a targeted nerve or portion of a nerve. For example, the agent may be delivered locally to the renal nerves to impair their function and treat hypertension. One variation of a delivery device includes one or more needle housings supported by a balloon. A delivery needle is slidably disposed within a needle lumen of each needle housing. 1. A method for treating hypertension in a patient , the method comprising:delivering a cardiac glycoside locally to a portion of a renal nerve in an amount that affects function of the renal nerve and lowers blood pressure of the patient.2. The method of claim 1 , wherein the amount of the cardiac glycoside delivered reduces nerve conductance in the portion of the renal nerve.3. The method of claim 1 , wherein the amount of the cardiac glycoside delivered induces death of nerve cells in the portion of the renal nerve and prevents regrowth of nerve cells.4. The method of claim 1 , wherein the amount of the cardiac glycoside delivered affects nerve function by inducing neuro-muscular block claim 1 , sensory nerve block claim 1 , or clinical nerve block.5. The method of claim 1 , wherein the amount of the cardiac glycoside delivered is approximately 0.05-1 mg/kg.6. The method of claim 1 , wherein the volume of the cardiac glycoside delivered is approximately 0.05-5 ml per administration.7. The method of claim 1 , wherein the portion of the renal nerve constitutes the axonal segment.8. The method of claim 1 , wherein the portion of the renal nerve constitutes receptors that receive signals from cells that can activate nerves.9. A method for treating hypertension in a patient claim 1 , the method comprising:locally delivering a nerve affecting composition to a portion of a ...

APPARATUS FOR TREATING A TENNIS ELBOW BY MEANS OF PERCUTANEOUS INTERVENTION, AS WELL AS A HOLDER FOR USE WITH SUCH AN APPARATUS

An apparatus for treating a tennis elbow by percutaneous intervention, includes: 11. Apparatus () for treating a tennis elbow by means of percutaneous intervention , comprising:{'b': 2', '4, 'a body () having an actuating means () for operating the apparatus,'}{'b': 6', '2, 'a fixing part () arranged to fixably position the apparatus body () with respect to its surroundings,'}{'b': 8', '2', '4, 'a positioning device () connected to the body (), comprising a positioning part moveable upon actuation of the actuating means (),'}{'b': 10', '8', '10', '11', '12', '11', '12', '16', '10', '13', '14', '11', '12', '14', '12, 'a holder () releasably connected to the positioning part of the positioning device (), wherein the holder () comprises a top part () for the releasable connection to the positioning part and a bottom part () defining a support surface for being supported on an elbow tendon region of a person to be treated, the support surface during use at least partially extending along the elbow tendon region, the top part () and the bottom part () being spaced-apart and being connected by one or more connecting members (), wherein the holder () comprises a holder part () with a number of penetration means () arranged thereon in a pattern, wherein the top part () and the bottom part () are spaced-apart at such a distance that, before penetration of the elbow tendon, the penetration tips of the penetration means () are covered by the bottom part (),'}{'b': 13', '16', '4', '12', '16', '13', '14, 'the holder part () being moveable along the connecting members () upon actuation of the actuating means (), in the direction of the bottom part (), wherein the connecting members () act as guidance members for the holder part (), such that the penetration means () are controllably moved towards the elbow tendon region for penetration of the elbow tendon.'}212101514. Apparatus according to claim 1 , wherein the bottom part () of the holder () comprises a number of through- ...

FLUID DELIVERY DEVICE AND METHOD

A fluid delivery injector comprises a syringe defining a barrel; a plunger and a hollow needle provided within the barrel adapted for linear movement parallel to a longitudinal axis with a distal tip of the needle contained within the syringe. A fluid retention reservoir is defined at least in the barrel and is in fluid communication with the needle when pressure is applied to the fluid in the reservoir and to the plunger for moving the needle out of the barrel. A spring may be provided for retracting the needle when pressure is released from the plunger. 1. A fluid delivery injector comprising: a barrel with a peripheral wall having a longitudinal axis and a distal end wall;', 'a plunger movable with the barrel parallel to the longitudinal axis towards and away from the end wall;', 'at least one hollow needle anchored at its proximal end to the plunger and extending parallel to the axis towards the end wall with the needle contained within the barrel;', 'a fluid retention reservoir defined in at least the barrel;', 'the fluid retention reservoir in fluid communication with inlet port of the needle when a volume confining pressure is applied to the fluid;, 'a syringe havingwhereby the needle is projected beyond the end wall of the barrel only when pressure is applied to the plunger in the direction of the distal end wall.2. The fluid delivery injector as defined in claim 1 , wherein an energy storage device is provided within the syringe for retaining the plunger in a default position spaced from the end wall with the at least one hollow needle contained within the barrel and for returning the needle to the default position once the pressure is released from the plunger.3. The fluid delivery injector as defined in claim 1 , wherein the peripheral wall of the barrel is a collapsible energy storing material.4. The fluid delivery injector as defined in claim 1 , wherein the end wall is provided with a peirceable septum for sealingly engaging the needle.5. The fluid ...

SURGICAL NEEDLE COATINGS AND METHODS

The present invention provides novel medical devices for use in surgical procedures and methods for manufacturing novel medical devices. In some embodiments, the novel medical devices can include surgical needles that are capable of being repeatedly passed through tissue using minimal force. More particularly, the surgical needles can be manufactured with one or more coatings that provide the surgical needles with both durability and lubricity for ease of repeated and successive passes through tissue. Novel methods for manufacturing the surgical needles and for providing and applying coatings to the surgical needles are also provided. 1. A surgical needle , comprising:an elongate body having a tissue-penetrating tip at a distal end thereof and a suture attachment portion at a proximal end thereof; andan outer-most coating disposed on at least a portion of the elongate body, the outer coating comprising a hydroxyl-terminated polydimethylsiloxane;wherein the surgical needle is configured to have a substantially constant tissue-penetrating force after at least thirty passes of the tissue-penetrating tip of the elongate body through tissue.2. The surgical needle of claim 1 , wherein the elongate body has a refractory alloy surface.3. The surgical needle of claim 2 , wherein the refractory alloy is a tungsten-rhenium alloy.4. The surgical needle of claim 1 , further comprising a base coating at least partially disposed on a surface of the elongate body claim 1 , wherein the outer-most coating is disposed on the base coating.5. The surgical needle of claim 4 , wherein the base coating is formed from a base coating composition comprising a vinyl-functionalized organopolysiloxane.6. The surgical needle of claim 1 , further comprising claim 1 ,a primer coating disposed at least partially on a surface of the elongate body; anda base coating applied to at least a portion of the primer coating;wherein the outer-most coating is disposed on the base coating.7. The surgical needle ...

Pre-filled plastic syringe containing a VEGF antagonist

The present invention relates to a pre-filled syringe containing a VEGF antagonist and comprising a plastic barrel which is silicone-free, kits comprising this syringe and the use of the syringe for the administration of a VEGF antagonist in the treatment of ocular diseases. 1. Pre-filled syringe containing a liquid formulation of a VEGF antagonist and comprising a syringe barrel , wherein the syringe barrel is made of plastic and is silicone-free.2. Pre-filled syringe according to claim 1 , wherein the VEGF antagonist is an anti-VEGF antibody or an antigen-binding fragment of such antibody or a VEGF receptor fusion protein.3. Pre-filled syringe according to claim 2 , wherein the anti-VEGF antibody is ranibizumab or aflibercept.4. Pre-filled syringe according to claim 1 , wherein the antagonist concentration is 1 to 100 mg/ml.5. Pre-filled syringe according to claim 1 , containing less than 50 particles per ml of the liquid formulation having a diameter of 10 μm or greater.6. Pre-filled syringe according to claim 1 , containing less than 5 particles per ml of the liquid formulation having a diameter of 25 μm or greater.7. Pre-filled syringe according to claim 1 , having a slide force of less than or equal to 10N.8. Pre-filled syringe according to claim 1 , further comprising a silicone-free stopper.9. Pre-filled syringe according to claim 1 , wherein the syringe barrel is made of cycloolefin polymer or cycloolefin copolymer.10. Pre-filled syringe according to claim 1 , wherein the syringe barrel comprises an internal coating other than a silicone coating.11. Pre-filled syringe according to claim 1 , comprising a staked needle.12. Kit comprising one or more pre-filled syringes of .13. A method of administering the liquid formulation of the VEGF antagonist of the pre-filled syringe of to a patient having an ocular disease.14. The method of claim 13 , wherein the ocular disease is selected from the group consisting of age-related macular degeneration (AMD) claim 13 , ...

FLUID TRANSFER DEVICES

A fluid transfer device may include a fluid transfer tip that has a tapered friction fitting for a corresponding hub and an additional means for gripping a hub in a locked position when connected to the fluid transfer tip by the friction fitting. A disconnecting member is provided with a resilient bias that causes it to engage the gripping means and thereby assist in holding the hub in the locked position. The disconnecting member is moveable relative to the fluid transfer tip and against the resilient bias so as to release engagement of the gripping means, move the hub out of the locked position provided by the gripping means and release the hub from the friction fitting. 162.-. (canceled)63. A fluid transfer device or fluid transferring connection comprising:a male connector tip, the male connector tip being tapered to form a friction fit when inserted in a corresponding female hub;a female hub connected, in use, to the male connector tip at least by the friction fit;a disconnecting member moveable relative to the male connector tip between a first position and a second position spaced from the first position towards a distal end of the male connector tip; andmeans for gripping the female hub when connected to the tip in use;wherein the female hub comprises a tapered internal surface and an outer thread;wherein the gripping means is configured to grip the outer thread; andwherein the disconnecting member is arranged to release the gripping means from the outer thread when moving between the first and second positions.64. A fluid transfer device or fluid transferring connection according to claim 63 , wherein the gripping means operates automatically when the male connector tip is connected to the female hub.65. A fluid transfer device or fluid transferring connection according to claim 63 , wherein the disconnecting member is provided with a resilient bias.66. A fluid transfer device or fluid transferring connection according to claim 63 , wherein the gripping ...

PEN NEEDLE TIP

A needle tip assembly for a pre-loaded syringe or a pen needle injection device, the needle tip assembly including a body comprising a double-ended needle and being installable and removable from the pre-loaded syringe or pen needle injection device. A needle cap is configured to cover a skin puncturing end of the double-ended needle and is removable to exposed the skin puncturing end. An outer safety member has a first portion that surrounds the body and a second portion that surrounds the skin puncturing end. 1. A needle tip assembly for a pre-loaded syringe or a pen needle injection device , the needle tip assembly comprising:a body comprising a double-ended needle and being installable and removable from the pre-loaded syringe or pen needle injection device;a needle cap configured to cover a skin puncturing end of the double-ended needle and being removable to exposed the skin puncturing end; andan outer safety member having a first portion that surrounds the body and a second portion that surrounds the skin puncturing end, a first mode where the needle cap and the outer safety member are in an installed condition and the outer safety member is in an unlocked position;', 'a second mode where the needle cap is removed and the skin puncturing end is caused to penetrate a skin surface; and', the outer safety member is moved axially to a locked position; and', 'the outer safety member is in a locked position and is located in an axial position different from the unlocked position., 'a third mode where the needle cap is not reinstalled and one of], 'wherein the needle tip assembly has the following modes of operation2. The assembly of claim 1 , wherein claim 1 , in the third mode claim 1 , the outer safety member is locked to the body via ring member.3. The assembly of claim 1 , wherein claim 1 , in the third mode claim 1 , the body is installed on the pre-loaded syringe or pen needle injection device.4. The assembly of claim 1 , wherein claim 1 , in the third mode ...

Syringe assembly

A syringe assembly which has a barrel for containing one or more medicaments and a stopper disposed in the barrel defining and separating a first volume and a second volume within the syringe assembly. The stopper includes a permanent seal fluidly sealing the stopper to the barrel about the entire perimeter of the stopper intermediate the first volume and second volume, and a channel bypassing the permanent seal, the channel having a first opening in fluid communication with the second volume and a second opening selectively sealed from the first volume by a resilient seal. The resilient seal is moveable between a sealing configuration and an open configuration to selectively seal the channel from the first volume and is moveable from the sealing configuration to the open configuration upon fluid pressure in the first volume or second volume exceeding a first pressure threshold.

Hypodermic Interface Assembly

A hypodermic interface assembly is disclosed. The hypodermic interface assembly includes a hub, a cannula, and a cannula carrier. The cannula carrier is non-removably-connected to the cannula. The cannula carrier is controllably separable from the hub. 1. A hypodermic interface assembly comprising:a hub;a cannula; and wherein the cannula carrier is non-removably connected to the cannula, and', 'wherein the cannula carrier is controllably separable from the hub., 'a cannula carrier,'}2. The hypodermic interface assembly of claim 1 , further comprising an adhesive connecting the cannula to the cannula carrier.3. The hypodermic interface assembly of claim 2 , wherein the cannula carrier includes an adhesive-depositing passage claim 2 , and wherein the adhesive is deposited into the adhesive-depositing passage of the cannula carrier.4. The hypodermic interface assembly of claim 1 , wherein the cannula carrier includes at least one leg portion.5. The hypodermic interface assembly of claim 4 , wherein at least one leg portion of the cannula carrier includes a barb portion claim 4 , and wherein the hub includes a groove that is sized to receive the barb portion of the at least one leg portion.6. The hypodermic interface assembly of claim 1 , wherein the cannula is disposed within:a hub passage extending through the hub; anda cannula carrier passage extending through the cannula carrier.7. The hypodermic interface assembly of claim 6 , wherein an outer surface of the cannula is secured to an inner surface that defines the hub passage.8. The hypodermic interface assembly of claim 6 , wherein a first portion of an outer surface of the cannula is arranged in a spaced-apart relationship with respect to a first inner surface portion that defines a first cannula carrier passage portion of the cannula carrier passage of the cannula carrier claim 6 , wherein a second portion of the outer surface of the cannula is disposed adjacent a second inner surface portion that defines a ...

Hypodermic Interface Assembly

A hypodermic interface assembly includes a cannula and a hub. The hub is defined by a first portion and a second portion. The second portion of the hub is breakably-connected to the first portion of the hub. The cannula is joined to the second portion of the hub. The second portion of the hub is defined by an outer head surface portion having a first geometry. The second portion of the hub also includes an outer neck or groove surface portion having a second geometry. The first geometry of the outer head surface portion is greater than the second geometry of the outer neck or groove surface portion. 1. A hypodermic interface assembly comprising:a cannula; and wherein the second portion of the hub is breakably-connected to the first portion of the hub,', 'wherein the cannula is joined to the second portion of the hub,', 'wherein the second portion of the hub is defined by an outer head surface portion having a first geometry,', 'wherein the second portion of the hub is defined by an outer neck surface portion having a second geometry,', 'wherein the first geometry of the outer head surface portion is greater than the second geometry of the outer neck or groove surface portion., 'a hub defined by a first portion and a second portion,'}2. The hypodermic interface assembly of claim 1 , wherein the outer neck surface portion defines a substantially cylindrical neck portion.3. The hypodermic interface assembly of claim 1 , wherein the outer neck surface portion defines a substantially conical neck portion.4. The hypodermic interface assembly of claim 1 , wherein the outer neck surface portion defines a first surface portion that contributes to forming a V-shaped groove.5. The hypodermic interface assembly of claim 1 , wherein the cannula is disposed within a hub passage extending through the first portion and the second portion of the hub claim 1 , wherein the hub passage includes:a first hub passage portion extending through the first portion of the hub; anda second hub ...

Dispensing outlet, dispensing system, method of using a dispensing system, injection mold and method of producing a dispensing outlet

A dispensing outlet includes a housing with a first end of the housing having a first outlet and a second end of the housing having a mixing or reception space. The mixing or reception space is configured to receive a further component, and a pre-determined breaking point is formed between the first outlet and the mixing or reception space.

GEL DELIVERY CATHETERS, SYSTEMS, AND METHODS

An injection catheter system is disclosed. The system includes a catheter defining a first pressure transfer lumen adapted to retain a pressure transfer material, an actuator at a proximal end of the catheter adapted to deliver a pressure from a proximal end to a distal end of the first pressure transfer lumen via the pressure transfer material, a distal section defining at least a first internal chamber adapted to retain a therapeutic gel component, at least a first plunger retained in the first internal chamber, and an injection port for delivering a therapeutic gel component into a treatment location from the first internal chamber when the actuator is used to deliver a pressure via the pressure transfer material to move the first plunger to deliver a therapeutic gel component through the injection port. 1. An injection catheter system comprising:(a) a catheter defining at least a first pressure transfer lumen adapted to retain a pressure transfer fluid;(b) an actuator at a proximal end of the catheter adapted to deliver a pressure transfer fluid into a proximal end of the first pressure transfer lumen;(c) a distal section at a distal end of the catheter defining at least a first internal chamber adapted to retain a therapeutic gel component;(d) at least a first plunger retained in the first internal chamber, a proximal end of the plunger being in fluid communication with the first pressure transfer lumen and adapted to move within the first internal chamber; and(e) an injection port for injecting a therapeutic gel component into a treatment location from the first internal chamber when the actuator is used to deliver a pressure transfer fluid into the first pressure transfer lumen to move the first plunger to deliver a therapeutic gel component through the injection port.2. The injection catheter system of claim 1 , wherein the distal section further defines a second internal chamber adapted to retain a second therapeutic gel component.3. The injection catheter ...

SYRINGE

A syringe includes a syringe barrel including: a liquid drug discharge portion on a distal end of the barrel, an opening on a proximal end of the barrel, and a body portion for storing a liquid drug; a gasket located in the syringe barrel; and a plunger including: a shaft inserted in the syringe barrel from the opening, and a pressing portion located on a proximal end of the shaft, the pressing portion being pushable by a thumb to slide the gasket toward the liquid drug discharge portion. The syringe barrel further includes a brim-shaped finger hooking portion, and a sleeve-shaped gripping portion. 1. A syringe comprising: a liquid drug discharge portion on a distal end of the barrel,', 'an opening on a proximal end of the barrel, and', 'a body portion for storing a liquid drug;, 'a syringe barrel includinga gasket located in the syringe barrel; and a shaft inserted in the syringe barrel from the opening, and', 'a pressing portion located on a proximal end of the shaft, the pressing portion being pushable by a thumb to slide the gasket toward the liquid drug discharge portion,, 'a plunger including a brim-shaped finger hooking portion protruding from an outer circumferential surface of the syringe barrel so as to extend in a first direction, which is a radial direction approximately perpendicular to a central axis of the syringe barrel, the finger hooking portion being configured to be hooked with a finger, and', 'a sleeve-shaped gripping portion that is located between a distal end of the finger hooking portion and a proximal end of the liquid drug discharge portion and is configured to be held with at least a middle finger, a fourth finger, and a fifth finger., 'wherein the syringe barrel further includes2. The syringe according to claim 1 , wherein the gripping portion has an overall length of at least 70 mm along the central axis and an outer circumferential surface length of 40 to 95 mm.3. The syringe according to claim 1 , wherein:the syringe barrel includes ...

BLUNT CANNULA NEEDLE DEVICE

A needle device has a needle assembly including a hub having one end fitted with a blunt cannula. The blunt cannula has a base section, a central section and a shaft having a distal apertured end. The needle of the needle assembly extends through an internal passage of the blunt cannula and is sealingly fitted to a portion of the internal passage. The hub of the needle assembly has another end connectable to a syringe. When the device is connected to a syringe, a fluid communication path is established between the apertured end of the shaft and the interior of the syringe via the lumen of the needle. The shaft of the blunt cannula is usable to pierce the seal of a fluid store while maintaining the needle in an unused state for subsequent patient use. The distal end of the shaft may be protected by an end cap. 1. A medical device comprising: a base section adapted to couple to a needle hub;', 'a central section distally adjacent to the base section having an internal central passage;', 'a shaft extending distally from the central section, the shaft having an internal shaft passage in alignment with the central passage along a longitudinal axis to form a longitudinal passage along the blunt cannula; and, 'a blunt cannula having'}a needle assembly having a needle extending from a needle hub;wherein the longitudinal passage is configured to sealingly receive the needle from the needle assembly so that a seal fit is formed between the needle and the longitudinal passage at at least a portion thereof when the needle assembly and the blunt cannula are coupled to each other; andwherein the needle assembly with the blunt cannula coupled thereto is adapted to be attached to a syringe for use with a fluid store.2. The device of claim 1 ,wherein the shaft of the blunt cannula comprises an apertured end; andwherein the needle comprises a sharp distal end;whereby the apertured end is positioned distally from the sharp distal end when the needle is appropriately positioned within ...

MEDICAL ACCESS PORTS, TRANSFER DEVICES AND METHODS OF USE THEREOF

A medical system, comprising an implantable access port including an implantable access port body and at least one implantable access port needle; wherein the at least one needle is concealable inside the access port body in a concealed position and is exposable outside the access port body in an exposed position; wherein the at least one needle is arranged within the access port body to penetrate outwardly through skin of a subject from within the subject when the access port is implanted in the subject; a transfer device coupled to the at least one needle of the access port, the transfer device configured to transfer a fluid to and/or from the access port; and wherein the transfer device is configured to form a closed system with the access port, wherein the transfer device includes a fluid flow passage configured to transfer the fluid to and/or from the access port. 1. A medical system , comprising: wherein the at least one needle is concealable inside the access port body in a concealed position and is exposable outside the access port body in an exposed position;', 'wherein the at least one needle is arranged within the access port body to penetrate outwardly through skin of the subject from within the subject when the access port is implanted in the subject;, 'an implantable access port configured to be implanted into a subject, the access port including an implantable access port body and at least one implantable access port needle;'} 'wherein the transfer device is configured to form a closed treatment system with the access port, wherein the transfer device includes a fluid flow passage configured to transfer the fluid to and/or from the access port.', 'a transfer device coupled to the at least one needle of the access port, the transfer device configured to transfer a fluid to and/or from the access port; and'}2. The medical system of claim 1 , wherein:the transfer device is configured to inhibit transfer of environmental contaminants into the treatment ...

INJECTION NEEDLE ASSEMBLY AND DRUG INJECTION DEVICE

An injection needle assembly includes a needle tube, a needle hub configured to hold the needle tube, a protector, a biasing member, and a restriction mechanism. The restriction mechanism is configured such that, after the protector has moved from the first position to the second position and has further returned from the second position to the first position, the restriction member restricts the protector from moving from the first position to the second position again. At least a portion of the biasing member is disposed on a needle tip side of the restriction mechanism in the axial direction. 1. An injection needle assembly comprising:a needle tube having a needle tip configured to puncture a living body;a needle hub holding the needle tube;a protector movable between a first position at which the needle tip of the needle tube is covered and a second position at which the needle tip of the needle tube is exposed;a biasing member configured to bias the protector toward the needle tip of the needle tube along an axial direction of the needle tube; anda restriction mechanism configured such that, after the protector has moved from the first position to the second position and has further returned from the second position to the first position, the restriction member restricts the protector from moving from the first position to the second position again,wherein at least a portion of the biasing member is disposed on a needle tip side of the restriction mechanism in the axial direction.2. The injection needle assembly according to claim 1 , wherein:one of the needle hub or the protector comprises a slide groove,the other of the needle hub or the protector comprises a slide protrusion slidably inserted into the slide groove, andthe restriction mechanism comprises the slide protrusion and a return restriction portion provided at the slide groove to contact the slide protrusion.3. The injection needle assembly according to claim 1 , wherein:the protector comprises a ...

INJECTION NEEDLE ASSEMBLY AND MEDICINE INJECTION APPARATUS

An injection needle assembly includes a needle tube, a needle hub holding the needle tube, a protector, a biasing member, a sliding groove, and a sliding protrusion. The protector is movable between a first position at which the needle tip of the needle tube is covered and a second position at which the needle tip of the needle tube is exposed. The sliding groove is located at one of the needle hub or the protector. The sliding protrusion is located at the other of the needle hub or the protector and is slidably disposed in the sliding groove, 1. An injection needle assembly comprising:a needle tube having a needle tip configured to puncture a living body;a needle hub holding the needle tube;a protector movable between a first position at which the needle tip of the needle tube is covered and a second position at which the needle tip of the needle tube is exposed;a biasing member configured to bias the protector toward the needle tip of the needle tube along an axial direction of the needle tube;a sliding groove that is located at one of the needle hub or the protector; anda sliding protrusion that is located at the other of the needle hub or the protector and is slidably disposed in the sliding groove, a first sliding portion that extends along the axial direction of the needle tube,', 'an inclined portion that communicates with the first sliding portion and is inclined with respect to the axial direction of the needle tube and the circumferential direction of the needle tube, and', 'a second sliding portion that communicates with the inclined portion and extends along the axial direction of the needle tube., 'wherein the sliding groove comprises2. The injection needle assembly according to claim 1 ,wherein a groove depth of the first sliding portion is less than a groove depth of the second sliding portion.3. The injection needle assembly according to claim 1 ,wherein the biasing member is disposed on a needle tip side of the sliding groove in the axial direction. ...

SYRINGE ASSEMBLY, SYRINGE ASSEMBLY PACKAGING, AND PREFILLED SYRINGE

A syringe assembly includes: a barrel with a puncture needle; and a cap that is mounted on the barrel and in which a tip of the puncture needle is located. The cap includes: a seal cap that is made of an elastic material and that is water vapor permeable for autoclave sterilization; and a cylindrical cover member made of a thermoplastic plastic material that is harder than the seal cap. The cylindrical cover member and the seal cap are configured such that a force of engagement between the cylindrical cover member and the seal cap is increased by autoclave sterilization. 1. A syringe assembly comprising: a barrel body portion,', 'a nozzle portion disposed at a distal end of the barrel body portion, and', 'a puncture needle including a puncture needle tip at a distal end of the puncture needle and having a proximal end fixed in the nozzle portion; and, 'a barrel comprising a seal cap that includes a closed distal end portion, an open proximal end portion, a hollow portion including a puncture needle storage portion storing the puncture needle, an insertion-allowing portion into which the puncture needle tip of the puncture needle stored in the puncture needle storage portion is insertable, and a seal portion in contact with the nozzle portion to seal the puncture needle storage portion, and', 'a cylindrical cover member mounted at an outer side of the seal cap;, 'a cap mounted to the barrel and sealing the puncture needle tip, the cap comprisingwherein the seal cap is made of an elastic material and is permeable to water vapor permeable for high-pressure steam sterilization, and the cylindrical cover member is made of a thermoplastic material harder than the seal cap; andwherein the seal cap and cylindrical cover member are configured such that a force of engagement between the cylindrical cover member and the seal cap is increased by autoclave sterilization of the syringe assembly.2. The syringe assembly according to claim 1 , wherein the seal cap and cylindrical ...

IMAGE-GUIDED LUMBAR PUNCTURE ASPIRATION AND INJECTOR SYSTEM AND METHOD

An image-guided lumbar puncture aspiration and injector system. The system includes an auto-injection device having a housing, at least one syringe having a fluid, a controller, a processor, a memory, and a display. An imaging device is communicatively coupled to the auto-injection device and captures images of a lumbar puncture area of a patient to be displayed on the display of the auto-injection device, helping identify a location for a lumbar puncture procedure. A needle assembly is coupled to the at least one syringe of the auto-injection device. An outer needle is adapted to be inserted into a location of the lumbar puncture area identified by the imaging device, and an inner needle is adapted to be inserted into the dura of the patient. The outer sheath needle protects the inner needle from contaminants. The controller operates the auto-injection device based on a programmed infusion and aspiration profile. 1. An image-guided aspiration and injector system , comprising:an auto-injection device having a housing, at least one syringe carried by the housing and having a fluid, and a controller disposed within the housing,;an imaging device coupled to the auto-injection device and adapted to capture at least one image of a lumbar puncture area of a patient; anda needle assembly coupled to the at least one syringe of the auto-injection device, the needle assembly including an outer needle adapted to be inserted into a location of the lumbar puncture area of the patient identified by the imaging device, and an inner needle disposed within the outer needle and adapted to be inserted into a dura of the patient,wherein the controller is configured to retrieve an infusion and aspiration profile, the infusion and aspiration profile comprising an infusion and aspiration protocol for the at least one syringe, the controller configured to operate the auto-injection device based on the infusion and aspiration protocol.2. The system of claim 1 , wherein the lumbar puncture ...

METHOD FOR PENETRATING TISSUE

A tissue penetrating system has a housing member. A plurality of penetrating members are positioned in the housing member. A tissue stabilizing member is coupled to the housing. A penetrating member sensor is coupled to the plurality of penetrating members. The penetrating member sensor is configured to provide information relative to a depth of penetration of a penetrating member through a skin surface. 1. A method for injecting an agent to a tissue site , comprising:measuring an amount of elastic tenting of skin of the body part when a penetrating member depresses the skin in a direction inward below a surface of the skin to determine elasticity of the skin;storing in a processor the amount of elastic tenting of the skin;selecting a driver profile from a set of alternative driver profiles stored in the processor that includes elastic tenting of the skin and a depth setting using stored tenting information in the processor, which is dependent on a value of the measured amount of elastic tenting and influences the injection of the agent;settling at the depth setting for a certain period of dwell time before starting to withdraw from the withdrawal site;injecting an agent;wherein the dwell time is related to the amount of elastic tenting of the skin depressed by the penetrating member trying to puncture the surface of the skin and variance in skin deformation.2. The method of claim 1 , wherein selecting a setting includes determining at least one of the penetrating member position and acceleration.3. A method for injecting an agent to a tissue site claim 1 , comprising:measuring an amount of elastic tenting of skin of the body part when a penetrating member depresses the skin during a number of agent injections, the elastic skin tenting being in a direction inward below a surface of the skin;storing in a processor the amount of elastic tenting of the skin;selecting a driver profile from a set of alternative driver profiles stored in the processor that includes ...

SKIN TREATMENT SYSTEMS AND METHODS USING NEEDLES

A device for treating the skin comprises a handpiece assembly having a distal end and a proximal end and a tip on the distal end of the handpiece assembly. The handpiece assembly includes a fluid delivery conduit, a waste conduit and/or an energy delivery conduit. Further, the tip is configured to contact the skin. The tip comprises a peripheral lip and a plurality of needles generally positioned within the peripheral lip. The tip also comprises at least one opening in fluid communication with a fluid delivery conduit, at least one opening in fluid communication with a waste conduit and/or an energy contact point in electrical communication with an energy contact point and energy conduit in the main body portion. The plurality of needles may be movable with respect to the peripheral lip through the use of a pneumatic or other force. 1 'a working end that includes a plurality of needles configured to engage and penetrate the skin and positioned on a plane parallel to a peripheral lip on the working end of the skin treatment device;', 'placing the working end of a skin treatment device against a portion of the skin of the patient wherein the skin treatment device comprisescausing the plurality of needles to penetrate the skin; andremoving the working end of the skin treatment device from the portion of skin.. A method for treating the skin of a patient, the method comprising: This application is a continuation application of U.S. patent application Ser. No. 14/211,089, filed Mar. 14, 2014, which claims the priority benefit under 35 U.S.C. § 119(e) of U.S. Provisional Application No. 61/788,420, filed Mar. 15, 2013, the entireties of both of which are hereby incorporated by reference herein.This application relates generally to skin treatment, and more specifically, to apparatuses, systems and methods for treating a person's skin using one or more needles and/or other penetrating members.Abrasion of the outer layer or epidermis of the skin is desirable to smooth or ...

NEEDLE STORAGE MAGAZINE ASSEMBLY

A magazine assembly () that stores a plurality of needles () configured to engage a medication pen () via an adapter () for medication delivery, the magazine assembly () comprising a magazine housing () enclosing a plurality of hub chambers () each enclosing one of a plurality of needle hubs (), a connector () in each of the plurality of hub chambers (), each connector () engages one of the plurality of needle hubs (), and a plurality of enclosures () each sealing the plurality of hub chambers (), wherein a selected enclosure of the plurality of enclosures () is removed to expose a selected needle hub () of the plurality of needle hubs (), the adapter () attaches to the medication pen () to engage the selected needle hub () while disengaging the selected needle hub () from the hub chamber (), and the selected needle hub () is removed from the magazine housing () to prepare the medication pen () for medication delivery. 1. A pen needle assembly configured to engage a medication pen for medication delivery , the pen needle assembly comprising:a needle hub having a fluid passage;an adapter having a proximal end configured for coupling to the medication pen, and a distal end configured for coupling to the needle hub;an adapter septum disposed between the proximal end and the distal end of the adapter; andan adapter cannula fixed to the adapter, whereinwhen the needle hub is not engaged to the adapter, the adapter septum is closed, and when the needle hub is engaged to the adapter, the adapter septum is open to provide fluid communication between the needle hub and the adapter.2. The assembly of claim 1 , wherein said adapter cannula pierces said adapter septum when said needle hub is coupled to said adapter.3. The assembly of claim 1 , wherein the adapter cannula has a distal end for providing fluid communication with the needle hub.4. The assembly of claim 1 , wherein said adapter cannula has a distal end configured to pierce said adapter septum when said needle hub is ...

MOTORIZED DRUG DELIVERY DEVICE WITH NEEDLES AND ROLLER

A delivery device () includes a roller () rotatably mounted on an axle (), a reservoir (), and one or more hollow needles () positioned in the roller () in fluid communication with the reservoir (). As the roller () rotates about the longitudinal axis () of the axle (), a piston () pushes contents of the reservoir () through the needles (). An actuator () is operatively connected to the piston () for increasing a pushing force of the piston (). 110. A delivery device () comprising:{'b': 12', '14, 'a roller () rotatably mounted on an axle ();'}{'b': '40', 'a reservoir ();'}{'b': 16', '12', '40', '12', '14', '40', '16, 'at least one hollow needle () positioned in said roller () and in fluid communication with said reservoir (), wherein as said roller () rotates about a longitudinal axis of said axle (), contents of said reservoir () pass through said at least one hollow needle (); and'}{'b': 30', '12', '12', '30', '12', '14', '30', '40', '16, 'a piston () arranged with respect to said roller () such that there is relative sliding motion between said roller () and said piston () as said roller () rotates about the longitudinal axis of said axle (), said relative sliding motion causing said piston () to push contents of said reservoir () through said at least one needle ();'}{'b': 36', '30', '30', '40', '16, 'characterised by an actuator () operatively connected to said piston () for increasing a pushing force of said piston () that pushes the contents of said reservoir () through said at least one needle ().'}210361430143630. The delivery device () according to claim 1 , wherein said actuator () comprises a motor coupled to said axle () for rotating said axle claim 1 , and said piston () is threadedly coupled to said axle () claim 1 , such that increased torque supplied by said actuator () to rotate said axle increases the pushing force of said piston ().310361439. The delivery device () according to claim 1 , wherein said actuator () is coupled to said axle () via a ...

MODIFIED VERESS NEEDLE FOR TENSION PNEUMOTHORAX DECOMPRESSION

Disclosed are devices and methods for treating tension pneumothorax. A needle assembly may include an outer cannula defining a lumen and having a distal end portion with a sharp bevel, and an inner cannula slidably-disposed through the lumen of the outer cannula. The inner cannula moves between an extended and retracted position and includes a blunt distal end portion configured to extend beyond the sharp bevel of the outer cannula when the inner cannula is in the extended position. The blunt distal end portion can retract within the lumen of the outer cannula when the inner cannula is in the retracted position, thereby exposing the sharp bevel. The needle assembly further includes a bias disposed inside the housing and coupled to the inner cannula. A proximal end portion of the inner cannula is configured to extend through the housing when the inner cannula is in the retracted position. 1. A needle assembly , comprising:an outer cannula defining a lumen and having a proximal end portion and a distal end portion, the distal end portion comprising a sharp bevel facilitating insertion of the needle assembly into a subject;an inner cannula slidably disposed coaxially in the lumen of the outer cannula and being movable relative to the outer cannula between an extended position and a retracted position, the inner cannula defining a respective lumen and having a blunt distal end portion and a proximal portion, the blunt distal end portion extending beyond the sharp bevel of the outer cannula whenever the inner cannula is in the extended position and being at least partially retracted within the lumen of the outer cannula whenever the inner cannula is in the retracted position;a bias coupled to the inner cannula and outer cannula in a manner favoring automatic positioning of the inner cannula at the extended position unless the blunt distal end portion is experiencing a sufficient force to move the inner cannula automatically to the retracted position; anda visual ...

INJECTION NEEDLE ASSEMBLY AND DRUG INJECTION DEVICE

An injection needle assembly includes an injection needle, a fitting portion, and a hub. The fitting portion is formed into a cylindrical shape and has one end serving as a fitting opening. The fitting portion includes a female taper shape in which an inner diameter of a cylindrical hole of the fitting portion becomes smaller toward an inner side. The hub includes the fitting portion for holding the injection needle. The injection needle assembly is used such that the female taper shape of the fitting portion is fitted to a drug discharge tube, which has a male taper shape in which an outer diameter of a cylinder becomes smaller toward a tip. When the male taper shape of the drug discharge tube has a taper ratio of N/100, the female taper shape of the fitting portion is formed to have a taper ratio of M/100, where M>N. 1. An injection needle assembly comprising:an injection needle;a fitting portion formed into a cylindrical shape and comprising a fitting opening at one end, the fitting portion having a female taper shape in which an inner diameter of a cylindrical hole of the fitting portion becomes smaller from the fitting opening toward an inner side of the fitting portion; anda hub comprising the fitting portion and configured to hold the injection needle,wherein the female taper shape of the fitting portion is configured to be fitted to a drug discharge tube having a male taper shape in which an outer diameter of a cylinder becomes smaller toward a tip,wherein, when the male taper shape of the drug discharge tube has a taper ratio of N/100, the female taper shape of the fitting portion comprises a taper ratio of M/100, where M>N.2. The injection needle assembly according to claim 1 , wherein the fitting portion is formed such that M is determined based on N=6.3. The injection needle assembly according to claim 1 , wherein the fitting portion is formed within a range of M=1.5 N to 10 N.4. The injection needle assembly according to claim 1 , whereinthe fitting ...

Harvesting cannula

A harvesting cannula, including a plurality of ports configured and positioned to improve performance as compared to existing harvesting devices, according to various embodiments, is described herein.

PUNCTURE INJECTION INSTRUMENT

A puncture injection instrument including a hollow needle body including a substrate having a first surface and a second surface opposite to the first surface, the hollow needle body having one or more projections which are formed on the first surface and each have a through hole penetrating from a distal end of the projection to the second surface of the substrate, and one or more probes positioned outside a region where the one or more projections are formed. The one or more probes include an ultrasound probe or an optical coherence tomography probe. 1. A puncture injection instrument , comprising:a hollow needle body including a substrate having a first surface and a second surface opposite to the first surface, the hollow needle body having at least one projection which is formed on the first surface and has a through hole penetrating from a distal end of the projection to the second surface of the substrate; andat least one probe positioned outside a region where the at least one projection is formed,wherein the at least one probe comprises an ultrasound probe or an optical coherence tomography probe.2. The puncture injection instrument of claim 1 , further comprising:a holder configured to support the hollow needle body and including a medicine injection channel through which a medicine is supplied and injected through the through hole of the projection from the second surface of the substrate,wherein the holder is configured to support the at least one probe.3. The puncture injection instrument of claim 1 , wherein the at least one probe comprises an ultrasound probe which has a frequency range in which a center frequency is higher than 15 MHz and lower than 80 MHz.4. The puncture injection instrument of claim 2 , wherein the at least one probe comprises an ultrasound probe which has a frequency range in which a center frequency is higher than 15 MHz and lower than 80 MHz.5. The puncture injection instrument of claim 1 , wherein the at least one probe ...

DELIVERY DEVICES FOR NASOPHARYNGEAL MUCOSA TARGETS

A system for delivering a therapeutic agent to nasopharyngeal mucosa tissue has a shaft, a porous pad of compliant material coupled to the shaft near the distal end, and a drug reservoir. The porous pad is configured to expand from a contracted configuration to an expanded configuration. The expanded configuration is adapted to engage and conform to the mucosa tissue in a nasal cavity, and the contracted configuration has a size suitable for introduction into the nasal cavity. The drug reservoir holds a therapeutic agent and is at least partially covered by the porous pad. The drug reservoir is configured to release a fixed volume of the therapeutic agent into the porous pad within a period of less than about 120 minutes, and has a wall with a plurality of channels fluidly coupled with the porous pad. 1. A system for delivering a therapeutic agent to nasopharyngeal mucosa tissue , said system comprising:a shaft having a proximal end and a distal end;a porous pad of compliant material coupled to the shaft near the distal end, wherein the porous pad is configured to expand from a contracted configuration to an expanded configuration, the expanded configuration being adapted to engage and conform to the mucosa tissue in a nasal cavity, and the contracted configuration having a size suitable for introduction into the nasal cavity; anda drug reservoir holding a therapeutic agent, the drug reservoir being at least partially covered by the porous pad, the drug reservoir having a wall with a plurality of channels fluidly coupled with the porous pad.2. The system of claim 1 , wherein the drug reservoir is configured to release a fixed volume of the therapeutic agent into the porous pad within a period of less than about 120 minutes.3. The system of claim 1 , wherein the elongate central member comprises an elongate shaft.4. The system of claim 3 , wherein the elongate shaft comprises a central lumen extending therethrough.5. The system of claim 3 , wherein the elongate shaft ...

Nail Plate Growth Guide Surgical Implantation Kit

A surgical kit for the repair of a nail bed includes implantable nail plate guides adapted to guide the regrowth of a fingernail over a nail bed, drapes, a suture needle with absorbable suture, a suture needle with non-absorbable suture, wound dressings, and all instruments required to perform the procedure. The instruments preferably include an elevator, a needle driver, a clamp, a tweezers, and a scissors. The kit also includes anesthesia, a syringe, and needles for loading and then administering the anesthesia to the finger. The kit may include a tourniquet, antiseptic, and an antiinfective. Therefore, the kit assembles together several nail plate guides, the instruments for implanting a selected one of the nail plate guides onto the nail bed over a patient, the pre-implantation surgical preparation materials, and the post-implantation wound care materials. 1. A surgical kit for the repair of a nail bed on a human digit to aid in regrowth of a nail on the digit , comprises:a) a plurality of pre-formed nail plate guides of various sizes;b) at least one surgical drape;c) a local anesthetic;d) a syringe and at least one hollow needle for loading the anesthetic and then administering the anesthetic to numb the human digit;e) an elevator instrument having a flat, blunt end adapted to separate a broken nail on the digit from the nail bed;f) a plurality of suture needles with suture; 'wherein all elements of the kit are assembled together in a container.', 'g) wound dressings,'}2. The surgical kit of claim 1 , wherein the plurality of nail plate guides are frangibly coupled together on a plastic armature.3. The surgical kit of claim 1 , wherein the plurality of suture needles with suture includes claim 1 ,at least one suture needle with absorbable suture, andat least one suture needle with non-absorbable suture.4. The surgical kit of claim 1 , further comprising:an elastic tourniquet for the human digit.5. The surgical kit of claim 4 , further comprising:a clamp to ...

RUBBER STOPPER FOR DRUG CONTAINER, DRUG-ACCOMMODATING DRUG CONTAINER, AND DRUG CONTAINER SET

A rubber stopper includes: a main body; and a cylindrical container insertion portion extending downward from a lower surface of the main body and configured to fit into a neck portion of a drug container. The main body includes a peripheral edge portion that is disposed on a radially outer side of the container insertion portion and that is configured to abut on an upper surface of an opening portion of the drug container when attached to the drug container. The container insertion portion includes: an outer surface portion that is configured to annularly contact an inner surface of the neck portion, an upper inner surface portion that forms a columnar gap portion, and at least one inclined surface extending obliquely downward toward the outer surface portion of the container insertion portion. 1. A rubber stopper configured to be attached to a drug container that comprises a cylindrical body portion comprising a closed lower end and accommodating a drug therein , and a cylindrical neck portion extending upward from an upper end of the body portion and comprising an opening portion formed at an upper end thereof , an inner diameter of the neck portion being smaller than an inner diameter of the body portion and being substantially constant , the rubber stopper comprising:a main body; anda cylindrical container insertion portion extending downward from a lower surface of the main body and configured to fit into the neck portion of the drug container,wherein the main body comprises a peripheral edge portion that is disposed on a radially outer side of the container insertion portion and that is configured to abut on an upper surface of the opening portion when attached to the drug container, an outer surface portion that is configured to annularly contact an inner surface of the neck portion of the drug container in a liquid tight manner when the rubber stopper is attached to the drug container,', 'an upper inner surface portion that forms a columnar gap portion ...

Compact Medication Reconstitution Device and Method

A container usable for lyophilization, storage, and reconstitution of medication having only two parts, one of which is a plug component having a flow path terminating in a side outlet port and a second of which is a barrel component. The barrel component has a spiral mixing channel near its distal end in which powder medication is stored and upon reconstitution, yields a gradient concentration. The inner wall of the barrel includes a longitudinal diluent groove. To connect the plug outlet port with the longitudinal diluent groove, the plug or barrel has a 360° distribution groove encircling the plug and connecting to the plug outlet port. Regardless of what rotational orientation the plug has to the barrel, the diluent will always reach the mixing channel. 1. A reconstitution container device for reconstituting a dried medication , the reconstitution container device comprising: a wall with an inner surface within which forms a cavity; and', 'a distal end comprising an ejection connector port;, 'a barrel component comprising a fixed input end configured for receiving a diluent;', 'a fixed output end connected with the ejection connector port; and', 'an elongated mixing channel wall extending and providing an indirect, winding flow path for the diluent between the input end and the ejection connector port, the mixing channel configured for slowing a flow of the diluent and increasing a mixing time for the diluent and the dried medication; and, 'a mixing channel positioned within the cavity of the barrel component and configured for containing the dried medication, the mixing channel comprising a diluent connector port; and', 'a plug body having a proximal end, a distal end, a side having an outer surface, and an interconnecting lateral diluent channel with a plug outlet port, the plug outlet port opening at the side of the plug body in fluid communication with the input end of the mixing channel when the plug component is engaged with the barrel component., 'a plug ...

MECHANISM FOR SEQUENTIAL DOSE DELIVERY

The present invention provides a drug delivery device () for sequential administration of substances, comprising a first variable volume reservoir () holding a first substance and comprising a first outlet ( ) and a first displaceable wall (), a second variable volume reservoir () holding a second substance and comprising a second outlet ( ) and a second displaceable wall (), a first wall actuation structure () activatable to move the first displaceable wall () and thereby expel a dose of the first substance through the first outlet ( ), a second wall actuation structure () activatable to move the second displaceable wall () and thereby expel a dose of the second substance through the second outlet ( ), and a drive structure () for activating the first wall actuation structure () and the second wall actuation structure (). The drive structure () performs a predetermined movement during one sequential administration of the first substance and the second substance, the predetermined movement comprising a first part movement followed by a second part movement, and is configured to activate the first wall actuation structure () during the first part movement and to activate the second wall actuation structure () during the second part movement. 1. A drug delivery device for sequential administration of substances , comprising:a first variable volume reservoir holding a first substance and comprising a first outlet and a first displaceable wall,a second variable volume reservoir holding a second substance and comprising a second outlet and a second displaceable wall,a first wall actuation structure activatable to move the first displaceable wall and thereby expel a dose of the first substance through the first outlet,a second wall actuation structure activatable to move the second displaceable wall and thereby expel a dose of the second substance through the second outlet, anda drive structure for activating the first wall actuation structure and the second wall ...

MULTI-SITE INJECTION SYSTEM

A multi-site injection system includes a plurality of medicament delivering needles/microprotrusions, a needle/microprotrusion support, a supply of medicament, and a mechanism for providing the medicament to the plurality of needles/microprotrusions in order to effect delivery into a stratum corneum of a user. 150-. (canceled)51. A multi-site injection system comprising:a guide plate having a plurality of openings therethrough;a needle plate having a plurality of needles projecting therefrom, each needle being aligned with a corresponding opening in said guide plate, said needle plate being movable from a first position with the needles positioned behind a top surface of said guide plate to a second position with the needles projecting from the top surface through the openings; anda plunger base for moving said needle plate from the first to the second position.52. The system according to wherein said plunger bore includes a reservoir for medicament and needles include lumen therethrough in communication with said reservoir for delivery of the medicament into a stratum corneum of a users skin.53. The system according to wherein the needles and opening are arranged in a symmetric radial pattern.54. The system according to wherein the needles and opening are arranged in an asymmetric radial pattern.55. A multi-site injection system comprising:a handle;a syringe supported by said handle and including a plunger for dispensing a fluid medicament from said syringe;a manifold attached to one end of said handle and in fluid communication with said syringe;a plurality of needles, protruding from said manifold, for delivery of said fluid medicament from said manifold and into a stratum corneum of a user.56. The system according to wherein said manifold is disposed perpendicular to said handle.57. The system according to wherein said manifold comprises a plurality of concentric conduits interconnected with radial conduits.58. The system according to wherein the concentric ...

DEVICE AND METHOD FOR DELIVERY OF TWO OR MORE DRUG AGENTS

A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed. 116-. (canceled)17. A drug delivery device comprising:a motor configured to advance a stopper in a cartridge of medicament, the motor comprising a rotatable output shaft and a pinion attached to the output shaft;a controller; anda motion detection system configured to provide positional feedback to the controller, wherein the motion detection system comprises an optical encoder and at least one element operatively coupled to the pinion of the motor and configured to rotate with the pinion such that the at least one element passes through the optical encoder.18. A drug delivery device according to claim 17 , wherein the optical encoder is configured to send electrical pulses to the controller as the at least one element passes through the optical encoder.19. A drug delivery device according to claim 17 , wherein the at least one element is a plurality of elements symmetrically spaced around a cylindrical axis of the pinion.20. A drug delivery device according to claim 17 , wherein the controller is configured to monitor rotation of the output shaft and to detect a ...

DUAL-CHAMBER DELIVERY DEVICE

A drug delivery device configured to provide a dose of first medicament followed by a dose of second medicament is disclosed. The device includes a main exterior body and an interior body. The device further includes a dual-chamber reservoir with (i) a first chamber holding a first medicament and (ii) a second chamber holding a second medicament. The device also includes a needle and a plunger. After activation of the device, the plunger is configured to (i) move the dual-chamber reservoir a given distance in a distal direction with respect to the interior body so that a distal end of the needle extends out of the interior body and (ii) after moving the dual-chamber reservoir the given distance, move in the distal direction with respect to the dual-chamber reservoir so as to eject from the needle the first medicament followed by the second medicament. 121-. (canceled)22. A drug delivery device comprising:a main exterior body;an interior body axially moveable with respect to the main exterior body;a dual-chamber reservoir arranged in the interior body and axially moveable with respect to the interior body, the dual-chamber reservoir comprising (i) a first chamber holding a first medicament and (ii) a second chamber holding a second medicament;a needle in fluid communication with the dual-chamber reservoir; anda plunger,wherein axial movement of the interior body in a proximal direction with respect to the main exterior body activates the drug delivery device, andwherein, after activation of the drug delivery device, the plunger is configured to (i) move the dual-chamber reservoir a given distance in a proximal direction with respect to the interior body so that a proximal end of the needle extends out of the interior body and (ii) after moving the dual-chamber reservoir the given distance, move in the proximal direction with respect to the dual-chamber reservoir so as to eject from the needle the first medicament followed by the second medicament.23. The drug ...

Medical Device Assembly

Medical device assemblies having a connection mechanism for securely connecting a hub to fluid storage containers in a luer slip relationship are described. An exemplary medical device includes a hub forming a cavity, a second indicating element disposed within the cavity that engages the hub. Additional features of the medical device include a second indicating element contoured to form a line contact with the hub. In a specific configuration, the hub includes a first indicating element attached to the hub and extending proximally into the cavity having a protrusion. In a more specific configuration, the medical device includes a fluid storage container that has an indication system for visually indicating optimal fluid-tight engagement of the hub and the fluid storage container. 1. A medical device for use with a fluid storage container comprising:a hub including a sidewall having an inside surface defining a cavity, an open proximal end, and a distal end having an opening therethrough in fluid communication with the cavity;a first indicating element having a distal end attached to the distal end of the hub and a free proximal end extending into the cavity, the first indicating element forming a peripheral recess with the sidewall of the hub; anda second indicating element disposed in the cavity of the hub including an open proximal end, an open distal end and a body extending from the open proximal end to the open distal end, the body having an outside surface and an inside surface, the outside surface of the body of the second indicating element includes one or more lips disposed along one or more points along a length of the outside surface of the body that prevents the body of the second indicating element from entering the recess until a pre-determined distally-directed force is applied to the second indicating element.2. The medical device of claim 1 , wherein the one or more lips comprise a protruding point extending outward radially from the outside ...

SUSTAINED RELEASE TREPOSTINIL-COMPOUND MICROPARTICLE COMPOSITIONS

Provided herein are new compositions comprising novel microparticles that are configured to provide a long acting release of one or more treprostinil compounds when administered to mammalian subjects. The microparticles of the invention are biocompatible and typically injectable through a needle or other injection system. The invention also provides methods of using such compositions, such as in the treatment of pulmonary arterial hypertension. 1. A pharmaceutically acceptable composition comprising an effective amount of biocompatible , injectable , sustained-release treprostinil compound particles , at least about 90% of the particles having a maximum diameter of between about 10 μm and about 200 μm; at least 65% of the particles having a maximum particle diameter within 35% of the average particle diameter of the particles; and the particles releasing an effective amount of treprostinil over a treatment period of at least one day when administered to patients.2. The composition of claim 1 , wherein less than about 10% of particles of the composition have a maximum diameter that is more than 50% greater than the average diameter of particles in the composition.3. The composition of claim 2 , wherein the treprostinil compound is selected from the group comprising a) treprostinil; b) an analog or derivative of treprostinil; c) a prodrug claim 2 , hydrate claim 2 , solvate claim 2 , polymorph claim 2 , or salt of either of a) or b); or d) a mixture of any or all of (a) claim 2 , (b) claim 2 , or (c).4. The composition of claim 3 , wherein the composition does not comprise a carrier.5. The composition of claim 3 , wherein the particles of the composition comprise a carrier claim 3 , and the drug load of the particles is between 1-80%.6. The composition of claim 5 , wherein the carrier is a non-resorbable carrier.7. The composition of claim 5 , wherein the carrier is a resorbable carrier.8. The composition of claim 7 , wherein the particles comprise a resorbable ...

SYSTEMS FOR INHIBITING HETEROTOPIC OSSIFICATION

Systems for treating a targeted volume of muscle tissue to inhibit heterotopic ossification (HO) employ a delivery device including a reservoir containing a neuromuscular inhibitor and an injector assembly. The injector assembly can include an arrangement of needles and an injector operable to pass the neuromuscular inhibitor from the reservoir through the needles. The injector assembly can be configured to eject predetermined aliquots of a therapeutic dose of the neuromuscular inhibitor. The injector assembly can be shaped to compliment a targeted volume of muscle tissue within a larger volume of muscle tissue. The delivery of the aliquots can result in a therapeutic distribution of the therapeutic dose of neuromuscular inhibitor within the targeted volume of muscle tissue that is sufficient to prevent formation of an HO lesion but insufficient to induce paralysis of the larger volume of muscle tissue. 1. A system for treating a targeted volume of muscle tissue to inhibit heterotopic ossification (HO) , the system comprising:a delivery device comprising a needle and a reservoir containing a neuromuscular inhibitor, wherein the needle is sized for intramuscular injection of the neuromuscular inhibitor and wherein the delivery device is configured to eject predetermined aliquots of a therapeutic dose of the neuromuscular inhibitor through the needle; and the first opening is positioned such that when the needle is inserted into the first opening, a distal end of the needle is positioned at a first delivery location suitable for delivery of a first aliquot of the predetermined aliquots;', 'the second opening is positioned such that when the needle is inserted into the second opening, the distal end of the needle is positioned at a second delivery location suitable for delivery of a second aliquot of the predetermined aliquots; and', 'a spacing of the first delivery location and second delivery location in conjunction with a respective volume of each one of the first ...

APPARATUS AND METHODS FOR OCULAR INJECTION

An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location. 118-. (canceled)19. An apparatus , comprising:a medicament container, the medicament container including triamcinolone;a housing configured to receive a portion of the medicament container;a hub configured to be coupled to the medicament container and defining a passageway through which a puncture member is disposed, the hub being fixedly coupled to the puncture member such that the hub moves with the puncture member when the puncture member is moved relative to an eye, a distal end surface of the hub having a convex surface and being configured to contact a target surface of the eye when the triamcinolone is conveyed through the puncture member; andan actuation rod at least partially disposed within the medicament container,the medicament container, the actuation rod, and the puncture member collectively configured such that (1) a portion of the actuation rod moves within the medicament container in response to a force on the actuation rod when a distal end portion of the puncture member is disposed within a suprachoroidal space of the eye, and (2) movement of a distal end portion of the actuation rod within ...

Multi-Cartridge Fluid Delivery Device

A fluid delivery device for administering a first medicament and a second medicament includes a first fluid reservoir configured to contain the first medicament and a second fluid reservoir configured to contain the second medicament. The fluid delivery device may include one or more basal drive mechanisms to provide a basal delivery of one or more of the first and second medicaments. The fluid delivery device may further include one or more bolus drive mechanisms to provide a bolus delivery of one or more of the first and second medicaments.