ЭЛЕКТРОННОЕ СТИМУЛИРУЮЩЕЕ УСТРОЙСТВО

Vorrichtung zum Stimulieren des Gehirns einer Person

Vorrichtung zum Stimulieren des Gehirns (3B) einer Person (2), Folgendes umfassend: (a) einen Detektor (10) zum Erfassen eines induzierten oder eines vom Gehirn (3B) erzeugten spontanen physiologischen Signals; (b) eine Steuereinheit (12), die an den Detektor (10) angeschlossen ist, um das erfasste physiologische Signal mit einem Kriterium zu vergleichen, um eine optimale Einstellung eines variablen Signalparameters zu bestimmen; (c) einen Signalgeber (8) zum Anlegen eines elektrischen Stimulationssignals (ESS) an die Person (2), wobei mindestens ein Signalparameter des Stimulationssignals (ESS) durch schrittweises Annähern auf einen Optimalwert ermittelt und in einem für die Person angelegten Speicher oder Speicherbereich abgelegt wird.

Vorrichtung zur Behandlung eines lebenden Körpers zur Verringerung der Belastung des Herzens

Apparatus and electrode for transcranial electrotherapy

Implanted stimulation device for pain relief with insertion means having pain locating electrodes

A self-contained percutaneous stimulating device 10 comprises for neuromodulation in the management of chronic pain comprises a stimulating element with one or more pairs of electrodes 12, and an integral control unit 14 with may be battery powered or inductively powered. The device is in the form of a closed cylinder having a diameter of less than 1.2 to 1.5mm and is no more than 70mm in length to allow implantation through a needle 16 aided by an insertion wire 18. The needle 16 and wire 18 may be connected to a further external signal source 20 passing a locating current via leads 22, 34 to accurately position the device 10 at the site of the pain. The stimulating needle and the insertion wire are subsequently withdrawn to leave the device is in place. An x-ray opaque draw-string 36, 38 may aid later removal of the device.

Facial stimulation apparatus

Facial stimulation apparatus

The invention relates to facial stimulation apparatus configured to be worn on the a user's head, and which uses the ear (14) as an anatomical reference to ensure correct and repeatable placement of skin electrodes (16a, 16b) over the human facial nerves (12a-e) to facilitate Electrical Muscle Stimulation (EMS). Use of the ear as an anatomical reference ensures repeatable positioning of the electrode in contact with a sinate predetermined localised region of the face corresponding to the insertion of the facial nerve truck (10) overlying the sylomastoid foramen. The apparatus overcomes problems inherent in known devices and, in particular, requires no anatomical knowledge on the part of the end user for its safe and most effective placement.

Stimulation apparatus

Electrophysiological Catheter Systems

DEVICE FOR TRANSKUTANEN THE STIMULATION OF A NERVE OF THE HUMAN BODY

TRANS SEPTALE KARDIALE ELECTRODE LINE

SYSTEMS AND PROCEDURES FOR THE BILATERAL STIMULATION OF LINKING AND RIGHT BRANCHES THE DORSALEN GENITAL NERVES FOR THE TREATMENT OF MALFUNCTIONS, LIKE E.G. URINARY INCONTINENCE

SYSTEMS FOR HEATINDUCED RENALE NEURO MODULATION

PORTABLE ARRANGEMENTS AND SYSTEMS FOR THE FUNCTIONAL OR THERAPEUTIC NEUROMUSCULAR STIMULATION

EQUIPMENT FOR THE IMPLANTATION OF AN ELECTRICAL STIMULATION SYSTEM AND ELECTRICAL STIMULATION LINE OF THE TYPE OF PADDLE

THERAPEUTIC SIGNALS DIRECT TRANSFERRING EXTERNAL ACTIVATION NEURO IMPLANT

DEVICE FOR THE TREATMENT OF A LIVING BODY FOR THE DECREASE OF THE LOAD OF THE HEART

MODULAR STIMULATION POWER MAINS

GERÄT ZUR PUNKTUAL-STIMULATION

The invention relates to a device for the punctual stimulation of endings, located in the region of the ears, of nerves leading to brain stem nuclei, said device (1) having a battery-powered therapeutic current generator (3), which is arranged in a housing (2) to be worn in the ear region and is provided with an electronic circuit that forms a low-frequency therapeutic current, and said device also having at least one flexible line (5) proceeding from the therapeutic current generator (3) for connecting to an electrode to be positioned at a nerve ending and having a base electrode (7), which is likewise connected to the therapeutic current generator and by means of which the therapeutic circuit leading across the former electrode is closed, wherein the device (1), at least by means of an external part of said device (1), can be adapted to the shape of the body point of patient intended for the positioning of the device due to a mechanically pliable structure.

GERÄT ZUR PUNKTUAL-STIMULATION

The invention relates to a device for the punctual stimulation of the nerve endings located in the region of the ears, said device having a battery-powered therapeutic current generator (3) arranged in a housing (4) which is to be worn in the region of the ear, and said generator supplying a low frequency therapeutic current. The therapeutic current generator (3) has a plurality of output channels (9a, 9b, 9c), wherein each output channel is associated with its own stimulation electrode (6a, 6b, 6c), and these output channels are connected to a micro-computer circuit (10) on the input side. Each output channel (9a, 9b, 9c) contains an amplifier (15a, 15b, 15c), controlled by a digital-analogue converter (12) and designed for bipolar output signals. A control signal is preferably fed to the amplifiers (15a, 15b, 15c), said signal causing current strength and stimulation voltage behaviour in the output circuit of the respective amplifier (15a, 15b, 15c), said behaviour adapting to the resistance ...

AUTOMATIC INJECTION MECHANISM.

EQUIPMENT FOR THE TREATMENT OF NEUROVEGETATIVE DISTURBANCES.

SYSTEM FOR THE CHANGE OF THERAPY PARAMETERS

SYSTEM AND ELECTRODE TO THE PERCUTANEOUS ELECTRICAL THERAPY

Subcutaneous direct current nerve conduction block

The present disclosure relates to subcutaneous direct current (DC) nerve conduction block. A subcutaneous electrode can be implanted under a subject's skin between the subject's skin and a neural structure within the subject's body. The subcutaneous electrode can be coupled to a current generator. A DC can be configured by the current generator and delivered through the subcutaneous electrode to block conduction in the neural structure. The subcutaneous electrode eliminates an effect of an impedance of the subject's skin on the DC. The DC can be returned to the current generator by a return electrode.

Cannula

Abstract The present invention relates to a cannula (1), comprising a cannula body with a cannula tube (11) and a body part (10) 5 attached to the proximal end of the cannula tube (11), a control clip (30) having a mounting body (31) with at least one control element (35, 36), said control clip (30) being attachable laterally on the body part to form a first configuration (I). In addition, the present invention relates to a cannula body, a .0 contact clip (20) and a control clip (30) of a cannula (1) according to the invention. Figure 3 35 31 36 39 29 Fig. 3 30 35 2131 3639 32 22 18 19 Fig.4 ...

System and method for nerve stimulation

A system and method for stimulating a nerve, wherein the system includes a first waveform generator adapted to generate a first waveform having a frequency capable of stimulating a predetermined nerve of the mammal, a second waveform generator adapted to generate a carrier waveform having a frequency capable of passing through tissue of the mammal, a modulation device electrically coupled to the first and second waveform generators and adapted to modulate the first and carrier waveforms to create a modulated waveform, and an electrode electrically coupled to the modulation device and positioned substantially adjacent to skin of the mammal, and adapted to apply the modulated waveform thereto.

Regulation of blood pressure by coded nerve signals

Audiological transmission system

Systems, methods and devices for a skull/brain interface

Facial stimulation apparatus

The invention relates to facial stimulation apparatus configured to be worn on the a user's head, and which uses the ear (14) as an anatomical reference to ensure correct and repeatable placement of skin electrodes (16a, 16b) over the human facial nerves (12a-e) to facilitate Electrical Muscle Stimulation (EMS). Use of the ear as an anatomical reference ensures repeatable positioning of the electrode in contact with a single predetermined localised region of the face corresponding to the insertion of the facial nerve truck (10) overlying the sylomastoid foramen. The apparatus overcomes problems inherent in known devices and, in particular, requires no anatomical knowledge on the part of the end user for its safe and most effective placement.

Method and apparatus for the detection of aberrant neural-electric activity

Embodiments provide an apparatus and method for detection of aberrant neural-electric activity (ANEA) in the brain causing an epileptic seizure or other neurologic condition. One embodiment provides an apparatus for detection of ANEA comprising an introducer having at least one lumen. The introducer is introduced into brain tissue through an opening in the skull. A reference electrode is positioned at an introducer distal portion. A plurality of electrode members are advanceable within the at least one lumen with each member having an insulated portion and an exposed distal portion. The members have a non-deployed state in the introducer and a deployed state when outwardly advanced out of the introducer. In the deployed state, the members are substantially orthogonal to each other with the exposed distal portions defining a detection volume capable of determining an electric field vector produced by the ANEA and the direction of a foci of the ANEA.

Surgical access system and related methods

A surgical access system comprising a tissue dilation assembly and a tissue retraction assembly, both of which may be equipped with one or more electrodes for use in detecting the existence of (and optionally the distance and/or direction to) neural structures. A retractor assembly for creating an operative corridor to a spinal surgical target site is disclosed, comprising: a retractor body and a plurality retractor blades extending generally perpendicularly to the retractor body, the retractor body being operable to separate the at plurality of retractor blades relative to each; and a supplemental retractor blade assembly attachable to at least two of the plurality of retractor blades, the supplemental retractor blade assembly comprising an elongated supplemental retractor blade and a crossbar connector, the crossbar connector configured to be attached to said at least two retractor blades while engaging the supplemental retractor blade.

System for transmitting electrical current to a bodily tissue

In some embodiments, an apparatus includes a substantially rigid base and a flexible substrate. The substantially rigid base has a first protrusion and a second protrusion, and is configured to be coupled to an electronic device. The flexible substrate has a first surface and a second surface, and includes an electrical circuit configured to electronically couple the electronic device to at least one of an electrode a battery, or an antenna. The flexible substrate is coupled to the base such that a first portion of the second surface is in contact with the first protrusion. A second portion of the second surface is non-parallel to the first portion.

Pain management with stimulation subthreshold to paresthesia

Devices, systems and methods are provided for treating pain while minimizing or eliminating possible complications and undesired side effects, particularly the sensation of paresthesia. This is achieved by stimulating in proximity to a dorsal root ganglion with stimulation energy in a manner that will affect pain sensations without generating substantial sensations of paresthesia. In some embodiments, such neurostimulation takes advantage of anatomical features and functions particular to the dorsal root ganglion.

Systems and methods for recovery of motor control via stimulation to a substituted site to an affected area

A method of treating a living organism to achieve a heart load reduction, and apparatus for carrying out the method

Electro-nerve stimulator system and methods

Device and method for positioning an electrode in a body cavity

Electrical sensing/stimulation apparatuses for positioning at least one electrode within body tissue are provided. An electrical sensing/stimulation apparatus may comprise an elongate lead body having at least one internal lumen, at least one sensing/stimulation electrode, a deployable/retractable displacement member that moves or biases at least one electrode towards a prescribed direction by the user, a tissue attachment mechanism for affixing the distal segment of the device to body tissue, and an atraumatic distal lead body termination. In a retracted configuration, the attachment mechanism is positioned substantially within the distal segment of the lead body, and in the deployed configuration, the attachment mechanism extends from the axis of the lead body to engage body tissue.

Portable assemblies, systems, and methods for providing functional or therapeutic neurostimulation

Neurostimulation assemblies, systems, and methods make possible the providing of short-term therapy or diagnostic testing by providing electrical connections between muscles and/or nerves inside the body and stimulus generators and/or recording instruments mounted on the surface of the skin or carried outside the body. Neurostimulation assemblies, systems, and methods may include a carrier and an electronics pod, the electronics pod including stimulation generation circuitry and user interface components. A power source and/or flash memory may be incorporated in neurostimulation assembly and/or the return electrode. The assemblies, systems, and methods are adapted to provide coordinated neurostimulation to multiple regions of the body.

Devices and methods for stimulating nerves

A device for stimulating nerves adjacent the vagina includes a nerve stimulating element coupled to a body. The nerve stimulating element is positioned and designed to stimulate the vesical, Frankenhauser' s and/or inferior hypogastric plexuses. The device may reside in the vaginal fornices.

Multichannel clip device and methods of use

A multichannel clip device and methods of use that facilitate connection of multiple electrical components of a first device and a second device for testing and/or verification are provided herein. Such multichannel clip devices can include a spring-loaded clip having multiple electrical contacts for coupling with a contact portion of a first device and which are connected to a proximal connector through a flexible stimulation cable. The contacts can be included within a neurostimulation lead connector and the proximal connector adapted to couple with standard connectors on a clinician programmer, each contact being coupled to a corresponding contact of the proximal connector to define multiple separate channels. Such clip devices allow clinicians to test and/or verify multiple neurostimulation lead electrodes with a clinician programmers without requiring separate connection of each electrodes to a probe or test device and further allows for repeated sequencing or multi-plexing of neurostimulation ...

DEVICES AND METHODS FOR STIMULATING NERVES

A device for stimulating nerves adjacent the vagina includes a nerve stimulating element coupled to a body. The nerve stimulating element is positioned and designed to stimulate the vesical, Frankenhauser' s and/or inferior hnogastric plexuses. The device may reside in the vaginal fomices.

Apparatus and method for transcranial electrotherapy

Pulse generator system for promoting desynchronized firing of recruited neural populations

An Implantable Pulse Generator (IPG) is disclosed that is capable of sensing a degree to which recruited neurons in a patient's tissue are firing synchronously, and of modifying a stimulation program to promote desynchronicity and to reduce paresthesia. An evoked compound action potential (ECAP) of the recruited neurons is sensed as a measure of synchronicity by at least one non-active electrode. An ECAP algorithm operable in the IPG assesses the shape of the ECAP and determines one or more ECAP shape parameters that indicate whether the recruited neurons are firing synchronously or desynchronously. If the shape parameters indicate significant synchronicity, the ECAP algorithm can adjust the stimulation program to promote desynchronous firing.

SYSTEMS AND METHODS RELATED TO THE TREATMENT OF BACK PAIN

The present invention reduces pain and improves function long-term in persons with back pain using electrical stimulation in the back. This approach involves an electrical stimulation device including at least one electrode adapted for insertion within an animal body with back pain and at least one pulse generator operatively coupled with the at least one electrode, wherein the pulse generator delivers electrical stimulation activating at least one muscle in a back of the animal body for pain relief. 2q/n/2q1Q ...

Devices for therapeutic nasal neuromodulation and associated methods and systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

TELEOPERATION OF A FREELY ROAMING ANIMAL THROUGH BRAIN STIMULATION

Electronic components, including a transceiver (220) for two-way wireless communications, are carried by a freely roaming animal (190) such as a rat. Electrodes are implanted in the brain of the animal to provide cues and rewards to the animal to achieved desired behaviors, including controlling the direction and speed of movement of the animal, and training the animal to recognize odors. Network interface components (265) allow a network of the animals to work together. Sensors (225, 230, 235, 245, 255, 260) carried by the animal provide information to a remote base station regarding, e.g., heading and location. Chemical or gas sensors, along with a video camera and a microphone provide information regarding an environment of the animal. The animal can search for people buried in rubble piles, and detect explosives, chemicals or other dangerous materials. A vehicle (500) for deploying the animal is also provided.

METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT

The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as "neuroplasticity". The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity ...

PAIN MANAGEMENT WITH STIMULATION SUBTHRESHOLD TO PARASTHESIA

Devices, systems and methods are provided for treating pain while minimizing or eliminating possible complications and undesired side effects, particularly the sensation of paresthesia. This is achieved by stimulating in proximity to a dorsal root ganglion with stimulation energy in a manner that will affect pain sensations without generating substantial sensations of paresthesia. In some embodiments, such neurostimulation takes advantage of anatomical features and functions particular to the dorsal root ganglion.

USE OF STIMULATION PULSE SHAPE TO CONTROL NEURAL RECRUITMENT ORDER AND CLINICAL EFFECT

An electrical tissue stimulation system, and programmer for providing therapy to a patient are provided. Electrodes are placed adjacent tissue (e.g., spinal cord tissue) of the patient, electrical stimulation energy is delivered from the electrodes to the tissue in accordance with a defined waveform, and a pulse shape of the defined waveform is modified, thereby changing the characteristics of the electrical stimulation energy delivered from the electrode(s) to the tissue. The pulse shape may be modified by selecting one of a plurality of different pulse shape types or by adjusting a time constant of the pulse shape.

DEVICE FOR STIMULATING LIVING TISSUE BY MICROELECTRODES, AND REMOVABLE MODULE AND USE THEREOF

L'invention concerne un dispositif de stimulation d'un tissu vivant, comprenant une matrice (1) de microélectrodes (11) de stimulation, disposées selon une configuration déterminée côte à côte et sélectionnables pour l'application d'un signal électrique de stimulation par l'une des microélectrodes. Suivant l'invention, il est prévu une surface supplémentaire (3) conductrice d'application contre le tissu vivant, au voisinage d'une pluralité déterminée de sections (210) d'application locale de microélectrodes (11), des moyens (32) de liaison étant prévus pour assurer une liaison électrique entre les zones (31), la surface conductrice supplémentaire (3) étant reliée en outre à un accès (33) et étant formée pour assurer une stimulation focale à partir d'une microélectrode (11).

APPARATUS FOR DETECTING BIOELECTRIC SIGNALS

An apparatus for detecting bioelectric signals according to the present invention, comprises: a detecting electrode, a reference electrode, a stimulating signal generating circuit, a micro-current amplifying circuit, a signal processing circuit and an output device. The detecting apparatus applies a stimulating voltage in the range of 0.5-3.0 V to a reference acupoint on human or animal body via the reference electrode, and detects simutaneously the response current in the range 10-11 - 10-4 A at different acupoints on the body with the detecting electrode at a certain pressure to acupoints, then the time response of the current is processed by the signal processing circuit to obtain the useful information for diagnosing diseases and verifying the therapeutic effects.

PATIENT MONITORING APPARATUS

PATIENT MONITORING APPARATUS A method of monitoring the depth of anaesthesia of a patient, comprising stimulating contractions in the oesophagus of the patient, for example using an inflatable oesophageal balloon, obtaining signals inductive of the oesophageal contractions using a sensor, and deriving from the signals an output indicative of the rate of occurrence of signals having a magnitude greater than a preset threshold value, and apparatus for carrying out the method. An alternative aspect comprises assigning a score value to each of a plurality of different bodily functions of a patient, for example heart rate, blood pressure, degree of sweating, and formation of tears, the said score values being indicative of a depth of anaesthesia or sedation, summing the score values, and producing an output from the summed score values indicative of the amount of anaesthetic to be fed to the patient.

EXTERNALLY ACTIVATED NEURO-IMPLANT SYSTEM

We present here, an externally activated neuro-implant which dir ectly transmits terapeutic signals. It is an implantable device carrying out neurostimulation. It basicly consists of two coils. There are no electronic components in the internal part of system. The passive coil, that is implanted under the skin, is connected with the electrod in the epudural space of the spinal cord. The active coil is placed on the skin overlying the passive coil. Thrapeutic signals produced by the transmitter outside the body are directly transmitted by inductive coupling acroos the skin of the patient.

SYSTEM AND METHOD FOR URODYNAMIC EVALUATION UTILIZING MICRO-ELECTRONIC MECHANICAL SYSTEM

An implantable urodynamic system (100) is provided one embodiment of which includes a power source (102), at least one sensor (102) for sensing at least one physiological property, a data transmission device (109) for transmitting data representing the at least one sensed physiological property to an exterior of the patient's bladder, and a collapsible housing (110) containing the power source and the at least one sensor therein. The collapsible housing has a collapsed configuration sized for insertion through the patient's urethra and into the patient's bladder, and an expanded configuration sized to remain within the bladder, but be unable to pass from the bladder into the urethra.

COUPLING PERCUTANEOUS DEVICES TO A PATIENT

Apparatuses and methods for supporting couplers for therapy administration and/or monitoring, and associated methods of manufacturing coupler supports. The apparatus can include a support member configured to rest on a body of a recipient proximate to a coupling area. The support member can include a first coupler location configured to removably carry a first coupler proximate to a first coupling position of the body (22) of the recipient. A second coupler location of the support member is configured to removably carry a second coupler proximate to a second coupling position of the body (22) of the recipient. The first and second coupler locations can be arranged to guide the practitioner to connect the couplers properly to the body. For example, the first coupler location can be positioned closer than the second coupler location to the first coupling position. Accordingly, practitioners can be more likely to connect the first and second couplers to the correct coupling position on the ...

DEVICE FOR THE DESYNCHRONIZATION OF NEURONAL BRAIN ACTIVITY

The invention relates to a device for desynchronizing neuronal brain activity. According to the invention, the activity in at least two partial zones of a brain area or at least two functionally related brain areas is reset by means of two electrodes, surprisingly resulting in desynchronization in the targeted population of neurons of the patient and the symptoms being repressed. The inventive device comprises at least two stimulation electrodes (2) which are triggered by a control mechanism so as to cause synchronization in the local environment thereof. Preferably, the stimuli of the N electrodes are essentially out of phase by 1/N.

METHOD OF ROUTING ELECTRICAL CURRENT TO BODILY TISSUES VIA IMPLANTED PASSIVE CONDUCTORS

The invention provides an implant for electrically stimulating a target body tissue in a subject. The implant provides a conductive pathway for a portion of electrical current flowing between surface electrodes positioned on the subject's skin and transmits that current to the target body tissue. The implant has an electrical conductor of sufficient length to extend from subcutaneous tissue located below a surface cathodic electrode to the target body tissue. The conductor has a pick-up end which forms an electrical termination having a sufficient surface area to allow a sufficient portion of the electrical current to flow through the conductor, in preference to flowing through body tissue between the surface electrodes, such that the target body tissue is stimulated. The conductor also has a stimulating end which forms an electrical termination for delivering the current to the target body tissue. A system and method incorporating the implant are also provided.

METHOD AND APPARATUS FOR GUIDING MOVEMENT OF A FREELY ROAMING ANIMAL THROUGH BRAIN STIMULATION

Movement of a freely roaming animal (190), such as a rat, is guided using electric stimulation of the animal's brain. Cues are provided to the animal to move forward by stimulating a reward center of the brain. Cues are provided to the animal to change its direction by stimulating portions of the animal's brain that control right and left movements, such as a cortical representation of whiskers of the animal. Multi-channel, remotely controlled equipment (140, 145, 150, 350) may be carried by the animal to enable independent energizing of electrodes attached to different regions of the animal's brain. A transmitter carried by the animal may report back data to allow monitoring. A component may be carried by the animal for carrying out a mission, such as for search and rescue or surveillance. Groups of animals may be controlled in real- time by coordinating their movements and tracking their locations.

DEVICES AND METHODS FOR TISSUE REMOVAL

Methods and apparatus are provided for selective surgical removal of tissue, e.g., for enlargement of diseased spinal structures, such as impinged lateral recesses and pathologically narrowed neural foramen. In one variation, tissue may be ablated, resected, removed, or otherwise remodeled by standard small endoscopic tools delivered into the epidural space through an epidural needle. Once the sharp tip of the needle is in the epidural space, it is converted to a blunt tipped instrument for further safe advancement. A nerve stimulator optionally may be provided to reduce a risk of inadvertent neural abrasion. Additionally, safe epidural placement of the working barrier and epidural tissue modification tools may be further improved with the- use of electrical nerve- stimulation- capabilities within the invention that, when combined with neural stimulation monitors, provide neural localization capabilities to the surgeon.

TREATMENT OF DERMAL GLANDS BY THE APPLICATION OF NON-THERMAL ENERGY

Described herein are methods and apparatuses for reducing or eliminating skin glands (e.g., sebaceous, eccrine and apocrine) with an electric treatment. Also described herein are methods for treating and/or preventing a disorder of a skin gland. For example, described herein are methods of treating sebaceous hyperplasia.

METHODS, DEVICES AND SYSTEMS FOR INDUCING COLLAGEN REGENERATION

A microneedling system may reciprocate a plurality of microneedles disposed on a handpiece into the skin of a patient. The microneedles and/or electrode plates may deliver RF energy to the patient for inducing collagen coagulation and regeneration. An interrogative modality such as ultrasound may combined into the microneedling handpiece or used as a separate instrument to interrogate the skin and identify or measure the thicknesses of constituent layers. The data obtained from the interrogative modality may be displayed and can be used to automatically adjust operating parameters of the microneedling device, including the penetration depth of the needles, the pulse duration, and/or the power level of the RF energy to optimize the treatment for the specific patient and/or condition being treated. The microneedling system may recall the skin measurements for distinct sectors of the skin which are expected to have different properties.

SPINAL TISSUE ABLATION APPARATUS, SYSTEM, AND METHOD

Flexible apparatus for ablating unhealthy spinal tissue. A housing includes a distal end and a proximal end. Multiple thermocouples mounted on the housing measure spinal tissue temperatures at locations between the proximal end and the distal end. A sensor measures spinal tissue impedance. The measured spinal tissue impedance corresponds to various physical state data of the spinal tissue. The spinal tissue impedance and the spinal tissue temperatures are displayed to the surgeon, enabling the surgeon to determine with certainty the location of the unhealthy spinal tissue, and to exercise control over the ablation apparatus. Nerve stimulation by IMP/STM switch system to detect nerve responses before and after treatment.

UNIPOLAR CANNULA

Monopolar cannula for anaesthesia, with a metal cannula tube (10), with an attachment (12) made of an electrically insulating plastic mounted at the proximal end of the cannula tube (10), with a connector piece arranged on the attachment (12) for the purpose of introducing a liquid into the cannula tube (10), and with a stimulation cable (24) which, with an electrically conducting wire, electrically contacts the cannula tube (10) in the region of the attachment (12), wherein the stimulation cable (24) can be laterally secured on the attachment (12) by a securing part (26) made of an electrically insulating plastic, wherein the securing part (26) has an electrically conductive contact part (38) connected to the wire, and wherein the contact part (38) engages in a recess (16) of the attachment (12) and contacts the cannula tube (10) when the securing part (26) is secured on the attachment (12).

DEVICES, SYSTEMS, AND METHODS FOR TREATMENT OF HEART FAILURE BY SPLANCHNIC NERVE ABLATION

Apparatuses and methods for treating a heart failure patient by ablating a nerve of the thoracic splanchnic sympathetic nervous system to increase venous capacitance and reduce pulmonary blood pressure. A method comprising: inserting a catheter into a vein adjacent the nerve, applying stimulation energy and observing hemodynamic effects, applying ablation energy and observing hemodynamic effects, applying stimulation energy after the ablation and observing hemodynamic effects and monitoring for presence of the lung in the ablation zone. An alternative method comprising: inserting a catheter into a vein adjacent the nerve, detecting that lung tissue is a safe distance from an ablation zone, and delivering ablation energy to the target nerve when lung tissue is a safe distance from the ablation zone.

TACTILE INPUT SYSTEM

The present invention relates to systems and methods for management of brain and body functions and sensory perception. For example, the present invention provides systems and methods of sensory substitution and sensory enhancement (augmentation) using tactile stimulators implanted under the skin.

NEURAL STIMULATION SYSTEM AND METHOD RESPONSIVE TO COLLATERAL NEURAL ACTIVITY

A neural stimulation system responsive to collateral neural activity that may arise in association with a neural stimulation procedure includes a stimulation interface configured to deliver stimulation signals to a target neural population, a monitoring interface positioned to receive signals corresponding to a neural activity within the target neural population, a stimulus unit coupled to deliver stimulation singals to the stimulation interface, and a sensing unit coupled to the monitoring device and the stimulus unit. The neural stimulation procedure may be directed toward rehabilitating, restoring, and/or enhancing one or more neural functions by facilitating and/or effectuating a neuroplastic change or reorganization; and/or affecting a neurological condition that exists on a continuous or essentially continuous basis absent the stimulation procedure. The sensing unit determines whether evidence of an collateral neural activity exists, whereupon the stimulus unit attempts to abate the ...

SYSTEM AND METHOD FOR VARYING CHARACTERISTICS OF ELECTRICAL THERAPY

A system and method for providing electrical nerve stimulation therapy to a recipient. A system in accordance with one embodiment to the invention can include electrode means (such as a percutaneous electrode) coupleable to a recipient. The system can further included signal generating means for applying an electrical signal to the electrode means. The signal generating means can include frequency varying means for applying the electrical signal to the electrode means at a plurality of frequencies.

AUDIOLOGICAL TRANSMISSION SYSTEM

The invention relates to an audiological transmission system (1) which is adapted to be worn on, in or behind the human ear and which comprises a hou sing (2), an electric amplifier (3), a loudspeaker (4) and an output channel (5) for outputting acoustic signals to the ear. The aim of the invention is to increase the functionality of such a transmission system. For this purpo se, the transmission system (1) comprises a device (6) for the transcutaneou s stimulation of a nerve of the human body, said device having at least one stimulation electrode (7) and at least one reference electrode (8) for trans cutaneous nerve stimulation.

RESUSCITATION DEVICE AND METHOD FOR RESUSCITATION

The invention relates to a resuscitation device for humans. The resuscitation device is designed to provide resuscitating stimulation of the respiratory area of the human brain stem, preferably from a location distant from said respiratory area. The invention further relates to a method for providing a rescuscitating treatment to a human. Parameters are measured by a number of sensor means and processed by a processing means for providing a response by a number of stimulation means. The stimulation means are electrical, mechanical or chemical stimulation means.

SYSTEM AND METHOD FOR SELECTIVELY STIMULATING DIFFERENT BODYPARTS

TREATMENTS FOR ANY AND ALL MENTAL/BRAIN NEURON/SPINAL CORD ILLNESS

Treatments for Any and all Mental Illness We could try Ritalin, GABA and St. John's Wort, GSM (gamma-secretase modulators), Magnolia Bark (for infections and scarring as well) - as well for methane fr om livestock. Parkinson's We are looking (placing in the brain) at 1. warmer (to even out and/or flash to use intensity to pacify and smooth out calming; pacing and leading a steady buzz the nerves a nd chatter between misfiring neurons) micro chip electrode, and/or 2. acoustic to the skull (for vibrations) and/or 3. we can use DTI to and Neural Links to trace the patter ns of the brain's activation process as each differing misfires are triggered, and thus anticipate the triggers and their expected spreading activation area of the brain and in addition 4. we can use electrodes (electro shock increase intensity and frequency - possibly for dr ug addicts and obesity, and OCD) and short circuit by pre-empting shakes/tremors (aimed at) caused by misfiring areas of the brains' neurons and literally ...

CONDUCTIVE TIP CATHETER

A conductive tip catheter includes a flexible tubular member defining a lumen that extends between a proximal end and a distal end. The conductive tip catheter also includes an electrically conductive metallic coil at least partially located within the lumen of the flexible tubular member. The electrically conductive metallic coil includes a first region located at a distal end of the metallic coil having a first pitch, a second region proximal to the first region having a second pitch that is greater than the first pitch, and a third region proximal to the second region having a third pitch that is different from the first pitch and the second pitch. A conductive tip is located at the distal end of the flexible tubular member, and the conductive tip defines a tip lumen in fluid communication with the lumen.

EQUIPMENT FOR ELECTRICAL THERAPIES

The present invention concerns an apparatus for electrical therapies comprising at least one electrocatheter (10, 210, 310, 410), or an electroneedle, and at least one power supply device (20, 120A, 320A) capable of electrically supplying the electrocatheter or electroneedle with at least one current suitable for carrying out at least one therapy, characterised in that it comprises at least one system (90) for testing whether at least one desired point of application of the electrocatheter or electroneedle (10, 210, 310, 410) has been reached in the body of a patient, the testing system comprising at least one device for emitting an electric testing current (20, 120A, 320B) with which to electrically supply the electrocatheter (10, 210, 310, 410) or electroneedle before the start of the therapy, and at least one reading device, capable of providing at least one reading (60) of at least one response generated in the patient (66) by the electrostimulation with the electrocatheter (10, 210 ...

SYSTEM FOR STIMULATING BONE GROWTH, TISSUE HEALING AND/OR PAIN CONTROL, AND METHOD OF USE

A system for use in stimulating bone growth, tissue healing, and/or pain control is described. The system includes a screw, a battery, a controller, and means for connecting the battery such that current is routed from the battery through the screw and thence to a target area of interest requiring treatment. The screw includes an elongate shaft having a length extending between opposite ends. The shaft has an insulating coating extending along at least a portion of the length. The thickness of the insulating coating at various portions of the shaft is modulated to optimally direct current to a target area of interest requiring treatment. The controller adjusts the duty cycle of the current flow over the treatment period ...

DERMATOME STIMULATION DEVICES AND METHODS

A nerve stimulation device includes a first waveform generator adapted to generate a first waveform having a first frequency capable of stimulating nerves within a dermatome, a second waveform generator adapted to generate a first carrier waveform having a second frequency capable of passing through tissue of a mammal, and a third waveform generator adapted to generate a second carrier waveform having a third frequency different than the second frequency and being capable of passing through the tissue of the mammal. The device includes a modulator electrically coupled to the first, second and third waveform generators and adapted to modulate the first waveform, the first carrier waveform, and the second carrier waveform to generate a modulated signal package capable of stimulating the nerves at different depths within the dermatome. The device also has an electrode electrically coupled to the modulator for applying the modulated waveform to the dermatomic region.

PERCUTANEOUS TIBIAL NERVE STIMULATOR

A tibial nerve stimulation device including a percutaneous electrode for inserting adjacent a stimulation site of a patient and a neurostimulator unit attachable to a transcutaneous electrode configured to be applied to skin adjacent the stimulation site. The neurostimulator unit includes a pulse generator electrically coupled to the percutaneous needle electrode and transcutaneous electrode and a microcontroller in communication with the pulse generator for monitoring a number of available treatment credits and activating the pulse generator, each available treatment credit corresponding to a treatment session and the pulse generator operable to be activated for performing the treatment session when the number of available treatment credits is at least one. A computer system is operable to communicate with the microcontroller of the neurostimulator unit for receiving a treatment credit request and transmitting the number of treatment credits purchased to the microcontroller of the neurostimulator ...

ELECTROSTIMULATION IN TREATING CEREBROVASCULAR CONDITIONS

SYSTEMS AND METHODS FOR RECOVERY FROM MOTOR CONTROL VIA STIMULATION TO A SUBSTITUTED SITE TO AN AFFECTED AREA

A device and methods for treating a subject with dysphagia or other neurological disease, neurological disorder, neurological injury, neurological impairment or neurodegenerative disease that affects voluntary motor control of the hyoid, pharynx, larynx, or oropharyngeal area is disclosed. A device of the invention generally comprises a vibrotactile stimulator for applying at least one stimulus to the outside surface of a subject's neck; a connector for attaching the vibrotactile stimulator to an outside surface of the subject's neck, and a switch control communicatively connected to the vibrotactile stimulator to selectively engage a manual stimulation module and/or automatic stimulation module. Stimulation of an outside surface of the throat area of a subject by a device of the invention stimulates a swallowing reflex in the subject.

DEVICES, SYSTEMS AND METHODS FOR THE TREATMENT OF MEDICAL DISORDERS

The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.

HANDHELD EMG STIMULATOR DEVICE WITH ADJUSTABLE SHAFT LENGTH

A nerve stimulating device with an adjustable length is shown and described. The device includes a handle and an elongated shaft with a stimulating electrode. The stimulating electrode can be selectively positioned to a plurality of distances relative to the handle. The device allows nerves in nerve regions at multiple positions relative to the surface of the patient's body to be stimulated with a single device.

SYSTEMS AND METHODS FOR THE TREATMENT OF PAIN THROUGH NEURAL FIBER STIMULATION

Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith ...

SYSTEMS AND METHODS FOR THE TREATMENT OF PAIN THROUGH NEURAL FIBER STIMULATION

Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith ...

SYSTEMS AND METHODS FOR THE TREATMENT OF PAIN THROUGH NEURAL FIBER STIMULATION

Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith ...

SUB-EPIDERMAL ELECTRIC WARNING DEVICE

A sub-epidermal electric warning device has electrodes penetrating through the patient's epidermis and bipolar electric warning signals are transmitted to the sub-epidermal tissue by these electrodes. A device for surveillance of vital signs, analyte levels, or treatment parameters is using a sub-epidermal electric warning device for notifying the patient in situations requiring intervention.

SYSTEMS AND METHODS RELATED TO THE TREATMENT OF BACK PAIN

The present invention reduces pain and improves function long-term in persons with back pain using electrical stimulation in the back. This approach involves an electrical stimulation device including at least one electrode adapted for insertion within an animal body with back pain and at least one pulse generator operatively coupled with the at least one electrode, wherein the pulse generator delivers electrical stimulation activating at least one muscle in a back of the animal body for pain relief.

SYSTEM, METHOD, AND COMPUTER ALGORITHM FOR CHARACTERIZATION AND CLASSIFICATION OF ELECTROPHYSIOLOGICAL EVOKED POTENTIALS

An automated EP analysis apparatus for monitoring, detecting and identifying changes (adverse or recovering) to a physiological system generating the analyzed EPs, wherein the apparatus is adapted to characterize and classify EPs and create alerts of changes (adverse or recovering) to the physiological systems generating the EPs if the acquired EP waveforms change significantly in latency, amplitude or morphology.

CONTINUOUS ANESTHESIA NERVE CONDUCTION APPARATUS, SYSTEM AND METHOD THEREOF

The invention generally relates to a continuous anesthesia nerve conduction apparatus and method thereof, and more particularly to a method and system for use in administering a continuous flow or intermittent bolus of anesthetic agent to facilitate a continuous or prolonged nerve block. In one embodiment, the apparatus includes a sheath having a proximal end, a distal end and at least one lumen extending from the proximal end to the distal end. The sheath also includes an embedded conductive element for transmitting an electrical signal from a proximal portion of the sheath to a distal portion of the sheath. A cannula is arranged in the at least one lumen of the sheath and has a distal end protruding from a distal portion of the sheath. The cannula is electrically coupled to at least a portion of the embedded conductive element and is configured to provide nerve stimulation.

APPARATUS FOR THE ELECTRICAL STIMULATION OF SKIN RECEPTORS

A device and a method for relieving chronic and acute states of pain as well as itch, for affecting the motoractivity of dis- abled people; or for increasing the flow-through of blood in underlying tiss ue are dislosed. the device comprises a shapable elec- trode plate (1) through which extend a plurality of electrodes (2) fixed in the electrode plate (1) and terminating, at their respec- tive free ends, in an electrode tip portion (7) for skin penetration, (a) th e electrode tip portion (7) of each electrode (2) being surrounded, at a distance of about 0.l-2.0 mm from the electrode tip (8), by a stop means (9) which separates the electrode plate (1) from the skin portion (10), (b) the electrodes (2) cooperating with a collector electrode (6) of opposite electrical polarity to the electrodes (2), and (c) the electrodes (2) and the collector electrode (6) being electrically connected to a control unit (4) designed to activate the electrodes (2) consecutively, so that when pressure is appli ...

METHOD AND SYSTEM FOR NEURAL TISSUE MODIFICATION

A method and system for altering or modifying a function of neural tissue in a patient. An electromagnetic signal is applied to the neural tissue through an electrode. The electromagnetic signal has a frequency component above the physiological stimulation frequency range and an intensity sufficient to produce an alteration of the neural tissue and a waveform that produces nonlethal temperature elevation of the neural tissue during application of the electromagnetic signal to the neural tissue.

Injektionsnadel zur Verwendung mit einer Injektionsspritze

Device for the biological stimulation of tissues

An RF voltage generated by an RF oscillator (13) is amplitude-modulated with the output voltage of an AF oscillator (14). The amplitude-modulated output voltage of the RF oscillator is applied to outer electrodes (2 and 3) via an impedance-matching transformer (15) and conductors (6, 7). Two parts of a broken bone (9) are held together mechanically by screws (11, 12) in the interior of a body part (8). One screw (11) is attached to a metal layer via an insulator and electrically connected to said metal layer via a diode. The metal layer forms an inner electrode (4). The other screw (12) penetrates a metal plate which forms a further internal electrode (5) and is connected in an electrically direct fashion to the metal plate. The RF oscillation serves to transmit the AF energy of the AF oscillator (14) to the said screws (11, 12) via a capacitor formed by the one external electrode (2) and the one internal electrode (4) as well as a further capacitor formed by the other external electrode ...

Hybrid system for the treatment of pain uses drug administration and electrostimulation and comprises an electrocatheter with holes in its distal end for drug infusion

Pain-treatment system comprises an electrocatheter (8) terminating with a connector, a drug flow regulator (21), cabling (3) for the hydraulic and electrical connection between the electrocatheter and the apparatus used for drug administration and electrical stimulation, a drug-administration pump device (1), an electronic circuit with battery for generating a stimulating electrical signal and a ground electrode (7). The distal end (10) of the electrocatheter comprises holes for infusion of the drug.

METHOD OF INTRODUCING PHARMACEUTICAL PREPARATIONS AND NUCLEIC ACIDS IN SKELETAL MUSCLE

ЭЛЕКТРОСТИМУЛЯТОР И СПОСОБ ЭЛЕКТРОСТИМУЛЯЦИИ

Изобретение касается электростимулятора, включающего блок формирования сигнала, содержащий задающий генератор, источник питания, по крайней мере два электрода, один из которых внутриполостной, причем дополнительно включает блок регулировки частоты сигнала, блок регулировки амплитуды сигнала, блок переключения режимов и мостовой усилитель мощности, вход которого соединен с источником питания, блок формирования сигнала, выполненный в виде последовательно соединенных блока регулирования частоты сигнала, задающего генератора, одновибратора, двух инверторов, между которыми включены последовательно генератор пачек импульсов и сумматор, при этом мостовой усилитель мощности двумя входами параллельно подключен ко второму инвертору, а его выходы присоединены - первый через блок регулировки амплитуды сигнала к первому электроду, а второй через блок переключения режимов ко второму электроду. Также в изобретении описан способ электростимуляции с использованием такого электростимулятора.

СПОСОБ ВВЕДЕНИЯ ФАРМАЦЕВТИЧЕСКИХ ПРЕПАРАТОВ И НУКЛЕИНОВЫХ КИСЛОТ В СКЕЛЕТНУЮ МЫШЦУ

... 1. Способ введения фармацевтических препаратов и/или терапевтических веществ, включая нуклеиновые кислоты и молекулы белка, в организм млекопитающего in vivo, при котором осуществляют инъекцию молекул и стимуляцию доставки этих молекул электрическим током, отличающийся тем, что инъекцию производят в скелетную мышцу, электроды располагают вблизи места инъекции таким образом, чтобы текущий через электроды ток проходил через место инъекции, при этом напряженность электрического поля стимуляции составляет от 25 до 200 В/см. 2. Способ по п.1, отличающийся тем, что электрическая стимуляция представляет собой одиночный прямоугольный биполярный импульс. 3. Способ по п.2, отличающийся тем, что указанный биполярный импульс имеет длительность примерно от 50 до 5000 мкс. 4. Способ по п.1, отличающийся тем, что электрическая стимуляция представляет собой примерно от 2 до 30000 прямоугольных биполярных импульсов. 5. Способ по п.4, отличающийся тем, что указанные биполярные импульсы имеют общую длительность ...

Methods and apparatus for renal neuromodulation

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

Systems and methods for treatment of urinary dysfunction

Method and system for thermally-induced renal neuromodulation

Systems, devices, and methods for monitoring and analyzing research animal behavior before, during and after brain electrical stimulation

Described are systems, devices and methods for facilitating the delivery of stimulation to, and the monitoring and recording of physiological signals (e.g., electroencephalographic signals) from a research subject. Devices include a headmount that includes a cranial frame and a headstage, and a connection between the headmount and external equipment used for stimulation, monitoring, and/or recording that is robust physically and electrically to optimize stimulation, monitoring and recording even while the subject remains ambulatory. In some embodiments, a hinged headmount allows the configuration to be easily manipulated during attachment and any subsequent adjustment or reattachment procedures and permits easy access to any wires or other components implanted in the subject. In some embodiments, a flexible cable extends out from the headmount at an acute angle relative to a horizontal plane of the headmount, to optimize strain relief as the subject moves about while attached to any stimulation, monitoring and/or recording equipment.

Peripheral nerve blockade device

A continuous nerve block apparatus comprising: (a) a hollow needle including a conduit extending between a proximal end and a distal end, the distal end being beveled between ten and fifty degrees; and, (b) a connector operatively coupled to the hollow needle, the connector including at least a first through passage in fluid communication with the conduit of the hollow needle, the connector including a first orifice allowing fluid communication from an exterior of the connector to the first through passage, the connector also including at least one valve.

Means and Method to Invade Skin, Mucosa, and Underlying Tissues with Little or No Pain

A means and a method is disclosed to diminish or eliminate the pain associated with a sharp object penetrating the skin, during such procedures as an injection, biopsy, or deriving a blood sample. To this end, repeated tapping, pressing, or rubbing or vibrating is performed over the skin at or near the site of penetration of the sharp object in conjunction with applying electricity on the skin. The invention discloses a method of using a skin-puncturing means, with enhanced features, to provide local anesthesia at the site of penetration of a sharp object.

Electrical stimulation of the sympathetic nerve chain

The present invention provides a method of affecting physiological disorders by stimulating a specific location along the sympathetic nerve chain. Preferably, the present invention provides a method of affecting a variety of physiological disorders or pathological conditions by placing an electrode adjacent to or in communication with at least one ganglion along the sympathetic nerve chain and stimulating the at least one ganglion until the physiological disorder or pathological condition has been affected.

System for electrical stimulation of nerves

A system for treatment of gait disorders reflects, with electrical stimulation patterns fed to electrodes ( 1, 8 ) arranged at the patient, on the event of heel-strike and heel-off, the events being generated by a wireless heel switch ( 5 ). The pulse generator ( 4 ) also transfers the electrical energy needed to operate the heel switch ( 5 ) wirelessly. The event signal from the heel switch ( 5 ) is modulated in order to achieve a longer operating range.

Method and apparatus for therapies of the cardiovascular and cardiorenal system

A system and method for controlling respiration depth or respiration rate is provided. A bipolar pair of a plurality of electrodes is selected in a location for stimulating a phrenic nerve. Electrical stimulation is delivered through a medical electrical lead electrode proximate phrenic nerve tissue. Modulating respiration is elicited in response to electrical stimulation of the phrenic nerve.

Universal closed-loop electrical stimulation system

A universal closed-loop functional electrical stimulation system comprising at least one electrode assembly adapted to deliver an electrical stimulation signal to the central nervous system, peripheral nervous system, or muscles of a user, a sensor system adapted to detect a mechanical response to a muscle stimulation signal of at least one muscle associated with a muscle group stimulated through the nervous system or proximate to the electrode assembly. An electrical stimulation device operably coupled to at least one electrode assembly and the sensor system, the electrical stimulation device including a control system to automatically receive feedback from at least one characteristic of the muscle from the detected muscle response and adjust at least one parameter of the muscle stimulation signal in real-time and in response thereto and a programmed microprocessor for controlling said electrical stimulation and receiving input from said sensor system.

Electrical stimulation of the sympathetic nerve chain

The present invention provides a method of affecting physiological disorders by stimulating a specific location along the sympathetic nerve chain. Preferably, the present invention provides a method of affecting a variety of physiological disorders or pathological conditions by placing an electrode adjacent to or in communication with at least one ganglion along the sympathetic nerve chain and stimulating the at least one ganglion until the physiological disorder or pathological condition has been affected.

Renal neuromodulation methods and devices for treatment of polycystic kidney disease

Methods for treating polycystic kidney disease with therapeutic renal neuromodulation and associated systems and methods are disclosed herein. One aspect of the present technology is directed to methods that at least partially inhibit sympathetic neural activity in nerves proximate a renal artery of a kidney of a patient. One or more measurable physiological parameter corresponding to the polycystic kidney disease can thereby be reduced. Moreover, central sympathetic drive in the patient can be reduced in a manner that treats the patient for the polycystic kidney disease. Renal sympathetic nerve activity can be modulated along the afferent and/or efferent pathway. The modulation can be achieved, for example, using an intravascularly positioned catheter carrying a neuromodulation assembly, e.g., a neuromodulation assembly configured to cryotherapeutically cool the renal nerve or to deliver an energy field to the renal nerve.

Systems and methods for percutaneous electrical stimulation

Systems and methods according to the present invention relate to a substantially extracorporeal pulse generator system for electrical stimulation of one or more target nerve or their branches using one or more preferably percutaneous leads each having one or more electrodes implanted in, on, around, or near the target nerve. Improved systems include a patch assembly configured to be adhesively mounted to a patient's skin and an electrical stimulation assembly configured to be mechanically mounted to the patch assembly. A preferred patch assembly, in addition to provide mechanical mounting of the stimulation assembly, provides a power source for the stimulation assembly, and may further serve as a return electrode. Associated system components and methods of use are also provided.

System for providing targeted electrical stimulation to tissue

Provided is a system that may be used in delivering targeted electrical stimulation to tissue, such as animal bodily tissue. A system according to the present invention includes a longitudinal stimulation probe that includes a first electrode disposed at a distal tip and a second electrically conductive surface spaced proximally from the first electrode. Another system according to the present invention may include an improved user interface including an improved probe/handle interface including high visibility indication.

Devices and Systems for Carotid Body Ablation

Methods and endovascular catheters for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via transmural carotid body ablation.

Method and apparatus for transdermal stimulation over the palmar and plantar surfaces

Various methods and devices for providing transdermal electrical stimulation therapy to a patient are provided. In certain variations, a method may include positioning a stimulator electrode over a glabrous skin surface overlying a target nerve of a subject. Electrical stimulation may be delivered through or across the glabrous skin surface to the target nerve to stimulate the target nerve, while remaining safe and tolerable to the patient. Electrical stimulation may be delivered at frequencies that may be painful or intolerable when applied over non-glabrous surfaces of the body. Various applicators or devices for providing transdermal electrical stimulation therapy are also provided.

Stimulation Apparatus

An apparatus ( 1 ) for applying stimulation to a body has a distributed control system comprising a first CPU ( 7 ) in a main unit ( 24 ), a second CPU ( 30 ) in a display and control unit ( 2 ) and a further CPU 5 in each of one or more interface cards ( 3, 4 ). The second CPU ( 30 ) is configured to control the operation of the first CPU ( 7 ), whilst the first CPU ( 7 ) is configured to control and coordinate the operation of the CPUs ( 5 ) in each interface card ( 3, 4 ).

Methods and apparatus for renal neuromodulation

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

Remote Control Module For Instruments

A monitoring system may include a processor and display system for displaying results from the monitoring. A user may be in a sterile field away from the processor and display system and selected input devices. A controller may be physically connected to the monitoring system from the sterile field to allow the user to control the monitoring system. 1. A stimulation monitoring system positioned in a non-sterile field out of a sterile field to stimulate at least a portion of a patient within the sterile field , comprising:a stimulation system configured to generate a stimulation voltage;a stimulation instrument configured to be positioned within the sterile field near the patient;a controller conductively connected to the stimulation instrument and configured to be positioned within the sterile field near the patient;a conductor physically connected to the stimulation system and the controller;wherein the controller includes an input to control at least one operation of the stimulation system.2. The stimulation monitoring system of claim 1 , wherein the input includes at least one switch;wherein the at least one switch is configured to be operated by a user within the sterile field.3. The stimulation monitoring system of claim 2 , wherein the at least one switch includes a push button switch configured to be depressed with a digit by the user.4. The stimulation monitoring system of claim 3 , wherein the controller includes an external housing;wherein the push button switch includes a first portion configured to extend form the housing to be directly engaged by the digit and a second portion having a toggle switch fixed to a printed circuit board placed within the housing;wherein the toggle switch is configured to generate a signal that is transmitted to the stimulation system;wherein the stimulation system includes a processor configured to receive the signal to control at least one operation of the stimulation system.5. The stimulation monitoring system of claim 1 , ...

VAGAL NERVE STIMULATION FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS

Devices, systems and methods are disclosed for treating one or more symptoms of central nervous system disorders in a patient, such as anxiety disorders, fibromyalgia, traumatic brain injury, PTSD, and others. A method includes positioning a contact surface of a device in contact with an outer skin surface of patient and applying an electrical impulse transcutaneously from the device through the outer skin surface of the patient to a vagus nerve in the patient for about 90 seconds to about 3 minutes. The electrical impulse is sufficient to modify the vagus nerve such that the symptoms of the central nervous system disorder are reduced. For chronic treatment of such disorders, a stimulation protocol is provided that includes two or more doses administered per day for a period of time sufficient to relieve the symptoms. 1. A device for treating symptoms of a central nervous system disorder in a patient , the device comprising:one or more electrodes configured for contacting an outer skin surface of the patient; andan energy source coupled to the electrodes, wherein the energy source is configured to generate at least one electrical impulse and to transmit the at least one electrical impulse transcutaneously from the electrodes through the outer skin surface of the patient to a vagus nerve in the patient according to a stimulation protocol that includes at least two doses administered each day for a plurality of days, wherein the doses each have a duration of about ninety seconds to about 3 minutes; andwherein the electrical impulse is sufficient to modify the vagus nerve such that the symptoms of the central nervous system disorder are reduced.2. The device of claim 1 , wherein the energy source is wirelessly coupled to the one or more electrodes.3. The device of claim 1 , further comprising an electrical connector coupling the energy source to the one or more electrodes.4. The device of claim 1 , wherein the one or more electrodes are configured for attachment to the ...

METHODS AND APPARATUS FOR THERMALLY-INDUCED RENAL NEUROMODULATION

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy. 117-. (canceled)18. A method for treating a hypertensive human patient , the method comprising:intravascularly positioning a thermal apparatus carried by a renal denervation catheter at least proximate to renal nerves of the patient;delivering thermal energy via the thermal apparatus to modulate a function of the renal nerves via thermal effects; andintravascularly removing the renal denervation catheter from the patient after delivering the thermal energy to conclude the procedure.19. The method of wherein intravascularly positioning a thermal apparatus comprises intravascularly positioning the thermal apparatus within a renal artery of the patient proximate to the renal nerves.20. The method of wherein the renal denervation catheter comprises an expandable element at a distal region of the catheter claim 18 , and wherein the thermal apparatus is carried by the expandable element claim 18 , and wherein the method further comprises:transforming the expandable element from a low-profile delivery configuration to an expanded treatment configuration within a renal artery of the patient after intravascularly positioning the thermal apparatus at least proximate to renal nerves and before delivering ...

Auricular nerve field stimulation device

An auricular nerve field stimulation device may include a first plurality of electrodes arranged to contact a ventral aspect of an auricle, a second plurality of electrodes arranged to contact a dorsal aspect of the auricle, and electrical circuitry coupled to the electrodes and configured to selectively apply electrical stimulation signals to the electrodes to cause a first set of trans-auricular currents to flow through the auricle between the first plurality of electrodes and respective ones of the second plurality of electrodes paired therewith according to a first pairing, and to cause a second set of trans-auricular currents to flow through the auricle between the first plurality of electrodes and respective ones of the second plurality of electrodes paired therewith according to a second pairing different from the first pairing, the first and second sets of trans-auricular currents to stimulate at least one auricular nerve field within the auricle.

Devices, systems and methods for the treatment of medical disorders

The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.

Subcutaneous direct current nerve conduction block

The present disclosure relates to subcutaneous direct current (DC) nerve conduction block. A subcutaneous electrode can be implanted under a subject's skin between the subject's skin and a neural structure within the subject's body. The subcutaneous electrode can be coupled to a current generator. A DC can be configured by the current generator and delivered through the subcutaneous electrode to block conduction in the neural structure. The subcutaneous electrode eliminates an effect of an impedance of the subject's skin on the DC. The DC can be returned to the current generator by a return electrode.

BRAIN STIMULATION SYSTEM INCLUDING DIAGNOSTIC TOOL

A system for treating a patient comprises a stimulator for stimulating brain tissue, a controller for setting stimulation parameters and a diagnostic tool for measuring patient parameters and producing diagnostic data. The stimulation parameters comprise test stimulation parameters and treatment stimulation parameters. The stimulator delivers test stimulation energy to the brain tissue based on at least one test stimulation parameter and delivers treatment stimulation energy to the brain tissue based on at least one treatment stimulation parameter. One or more treatment stimulator parameters are determined based on the diagnostic data produced by the diagnostic tool The system is constructed and arranged to treat a neurological disease or a neurological disorder. Methods of treating a neurological disease or neurological disorder are also provided. 1a stimulator for stimulating brain tissue;a controller for setting stimulation parameters comprising at least one test stimulation parameter of the stimulator and at least one treatment stimulation parameter of the stimulator; anda diagnostic tool for measuring at least one patient parameter and producing diagnostic data representing the at least one measured patient parameter;wherein the stimulator is constructed and arranged to deliver test stimulation energy to the brain tissue based on the at least one test stimulation parameter and to deliver treatment stimulation energy to the brain tissue based on the at least one treatment stimulation parameter;wherein the at least one treatment stimulator parameter is determined based on the diagnostic data; andwherein the system is constructed and arranged to treat at least one of a neurological disease or a neurological disorder.. A system for treating a patient comprising: This application is a continuation of U.S. patent application Ser. No. 15/714,782, filed Sep. 25, 2017, which is a continuation of U.S. patent application Ser. No. 14/917,917, filed Apr. 8, 2016, now U.S. ...

SYSTEMS AND METHODS FOR TREATMENT OF PAIN FOLLOWING AMPUTATION AND SURGICAL TISSUE REMOVAL

Paind felt in a given region of the body can be treated by stimulating a peripheral nerve at a therapeutically effective distance from the region where pain is felt to generate a comfortable sensation (i.e., paresthesia) overlapping the regions of pain. Systems and methods to reduce pain in a painful region following surgical amputation of an extremity or limb may include stimulating a peripheral nerve innervating the painful region with an electrode inserted into tissue and spaced from the peripheral nerve. This method may be used to help alleviate postoperative pain in patients following amputation of an extremity or limb. 1. A method to alleviate pain following an amputation surgery , the method comprising:inserting a coiled wire lead with at least one electrode percutaneously into a body within a therapeutically effective distance from at least one nerve to be transected; andapplying electrical stimulation through the at least one electrode to the nerve to be transected, thereby activating nerve fibers that innervate the region of pain expected from the amputation surgery in advance of the amputation surgery and causing an area of tingling sensations in the body, said area of tingling sensations being compared with an area affected by the at least one nerve innervating the region of pain expected from the amputation surgery.2. The method of claim 1 , wherein the at least one electrode comprises a pair of electrodes formed on the lead claim 1 , wherein the pair of electrodes are spaced apart with an insulated portion of the lead positioned therebetween.3. The method of claim 1 , wherein the electrical stimulation is provided to the nerve to be transected after said nerve is transected during the amputation surgery.4. The method of claim 1 , wherein the electrical stimulation includes a first parameter selected from a group consisting of: frequency claim 1 , pulse duration claim 1 , amplitude claim 1 , duty cycle claim 1 , pattern of stimulus pulses claim 1 , ...

APPARATUS AND METHOD FOR POSITIONING, IMPLANTING AND USING A STIMULATION LEAD

An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath. 1. A system for testing , positioning , introducing and deploying a lead for percutaneous peripheral nerve stimulation , the system comprising:a delivery sheath having a distal opening and comprising a stimulation probe and an outer sheath having a distal opening;an inner deployment mechanism, selectively carried within the outer sheath, including an inner sheath and an open-coiled helical stimulation lead having a conductive distal anchor and an integrated electrode; andwherein the stimulation probe delivers test stimulation without deploying the distal anchor; and wherein the conductive distal anchor is released out of the delivery sheath when the inner deployment mechanism and outer sheath are moved in to a releasing position and subsequently retracted in concert.2. The system according to claim 1 , wherein the delivery sheath includes at least one bevel.3. The system according to claim 2 , wherein the distal opening includes a fully rounded edge to prevent sharp contact with any portion of the stimulation lead coming into contact with the rounded edge.4. The system according to claim 2 , wherein the distal opening includes an ovally rounded edge with a variable radius.5. The system according to claim 1 , wherein at least a portion of an outer surface of the delivery sheath is coated claim 1 , textured claim 1 , or marked to increase ...

INTEGRATED ELECTROMYOGRAPHIC CLINICIAN PROGRAMMER FOR USE WITH AN IMPLANTABLE NEUROSTIMULATOR

An integrated electromyography (EMG) and signal/stimulation generation clinician programmer may be coupled with an implantable temporary or permanent lead in a patient and at least one EMG sensing electrode minimally invasively positioned on a skin surface or within the patient. Generally, the integrated clinician programmer may comprise a portable housing, a signal/stimulation generator, and EMG signal processor, and a graphical user interface. The housing has an external surface and encloses circuitry at least partially disposed within the housing. The signal/stimulation generator may be disposed within the housing and configured to deliver test stimulation to a nerve tissue of the patient via the implantable lead. The EMG signal processor may be disposed within the housing and configured to record a stimulation-induced EMG motor response for each test stimulation via the at least one EMG sensing electrode. The graphical user interface at least partially comprises the external surface of the housing and has a touch screen display for direct user interaction or for use with a keyboard, mouse, or the like. 1. A clinician programmer coupleable with an implantable temporary or permanent lead , the clinician programmer comprising:a portable housing having an external surface and enclosing circuitry at least partially disposed within the housing;a lead connector disposed on the housing for electrical connection with the implantable lead;a foramen needle stimulation connector disposed on the housing for electrical connection to a foramen needle;a signal generator disposed within the housing and configured to deliver a test stimulation to a nerve tissue of the patient via the implantable lead;a graphical user interface at least partially comprising the external surface of the housing and configured to facilitate positioning and programming of the implantable lead based at least on an observed motor response or an EMG recording of an EMG motor response for each test ...

System to Estimate the Location of a Spinal Cord Physiological Midline

Techniques for determining the location of a physiological midline are disclosed. A first technique evaluates the response to stimulation of spinal electrodes at peripheral electrodes on different sides of the body. In this technique, a spinal electrode's position relative to a physiological midline is determined based on a relationship between responses to its stimulation observed on different sides of the body. A second technique evaluates the response of spinal electrodes to stimulation of peripheral electrodes on different sides of the body. In this technique, a spinal electrode's position relative to a physiological midline is determined based on the different responses that it observes to stimulation on different sides of the body. 1. A non-transitory computer-readable medium , comprising instructions to cause control circuitry to:send instructions to a stimulation device to provide electrical stimulation at a first grouping of one or more of a plurality of spinal electrodes on an implanted paddle lead, wherein the stimulation at the first grouping results in a first centroid of stimulation,receive data that is indicative of a response to the first centroid of stimulation at each of one or more corresponding pairs of peripheral electrodes, wherein each pair of peripheral electrodes comprises electrodes that are positionable on different sides of the patient's body, andcalculate, based on the received data, a measure of a relative position of the first centroid of stimulation to a physiological midline.2. The computer-readable medium of claim 1 , further comprising instructions to cause the control send instructions to the stimulation device to provide electrical stimulation at a second grouping of one or more spinal electrodes on the implanted paddle lead claim 1 , wherein stimulation of the second grouping results in a second centroid of stimulation that is closer to the physiological midline than the first centroid of stimulation.3. The computer-readable ...

SYSTEM AND METHOD FOR IMPROVING NERVE FINDING FOR PERIPHERAL NERVE STIMULATION

A method of identifying a location for applying a stimulation therapy to treat a patient includes stimulating a first body region of the patient transcutaneously via a stimulus generator. The body region contains a first portion of a nerve that has an elongate shape. In response to the stimulating, action potentials received from a second portion of the nerve are monitored over a period of time. The second portion of the nerve is in a second body region of the patient that is located remotely from the first body region. Based on the monitoring, an optimized location of the second portion of the nerve is determined for applying the stimulation therapy to treat the first body region. 1. A method of identifying a location for applying a stimulation therapy to treat a patient , the method comprising:stimulating a first body region of the patient transcutaneously via a stimulus generator, wherein the body region contains a first portion of a nerve that has an elongate shape;monitoring, in response to the stimulating, action potentials received from a second portion of the nerve over a period of time, wherein the second portion of the nerve is in a second body region of the patient that is located remotely from the first body region; anddetermining, based on the monitoring, an optimized location of the second portion of the nerve for applying the stimulation therapy to treat the first body region.2. The method of claim 1 , further comprising: engaging different fascicles of the second portion of the nerve as the first body region is being stimulated claim 1 , wherein a different action potential is received each time a different fascicle is engaged.3. The method of claim 2 , wherein the engaging is performed at least in part via a needle or a paddle lead claim 2 , each of which is configured to engage with the second portion of the nerve and receive the action potential arising therefrom.4. The method of claim 3 , further comprising:inserting a percutaneous lead through ...

Trial neurostimulation system with a lead adapter

A system adapted for neurostimulation of a patient, using a trial stimulator unit for generating stimulation pulses to targeted tissue in a patient through at least one neurostimulation lead. The trial stimulator unit has at least one receiving connection port adapted to receive at least one lead adapter. The lead adapter has a receiving portion, a sliding portion and a connection port. The receiving portion receives a proximal end of a stimulation lead. The sliding portion couples to the receiving portion. The connection port is adapted to connect to at least one receiving connection port. A case for enclosing the trial stimulator unit and the at least one lead adapter is provided.

Method, system, and apparatus for dermatological treatment

Embodiments of dermatological cell treatment are described generally herein. Other embodiments may be described and claimed.

Surgical Access System and Related Methods

A surgical access system comprising a tissue dilation assembly and a tissue retraction assembly, both of which may be equipped with one or more electrodes for use in detecting the existence of (and optionally the distance and/or direction to) neural structures.

SYSTEMS AND METHODS FOR THE TREATMENT OF PAIN THROUGH NEURAL FIBER STIMULATION

Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith. 1. An electrical stimulation system comprising:a single contact electrode insertable in-vivo a therapeutically effective distance from a target afferent nerve fiber;an electrical stimulator operatively coupled with the single contact electrode to provide electrical stimulation through the single contact electrode to the target afferent nerve fiber generating an action potential in the target afferent nerve fiber while avoiding generation of unwanted responses in non-target nerve fiber.2. The electrical stimulation system of claim 1 , wherein the therapeutically effective distance is greater that 1 mm from the target afferent nerve fiber.3. The electrical stimulation system of claim 1 , wherein the generation of unwanted responses in the non-target nerve comprises generation of action potentials in a small sensory nerve fiber.4. The electrical stimulation system of claim 1 , wherein the generation of unwanted responses in the non-target nerve fiber comprises generation of action ...

NEUROLOGICAL STIMULATOR METHOD WITH DETACHABLE LEAD CONNECTION ARRANGEMENT

A method may include, using an electrode lead(s) having a proximal end and a distal end and comprising spaced apart electrodes carried by the distal end, positioning the electrodes adjacent nerves in a patient; using a subcutaneous lead connector plug comprising a housing electrically connected to the proximal end of the electrode lead(s) and defining a lead connection port(s) and an anchor point(s), positioning the housing along with the proximal end of the electrode lead(s) inside the patient; connecting the anchor point(s) to tissue beneath the patient's skin and, using a first generator lead having a distal end and a proximal end, plugging the distal end of the first generator lead into the lead connector port(s); and connecting the proximal end of the first generator lead to a first neural stimulation generator, and operating the first neural stimulation generator to provide electrical stimulation to the nerves via the electrodes. 1. A neural stimulation method comprising:using at least one electrode lead having a proximal end and a distal end and comprising a plurality of spaced apart electrodes carried by the distal end, positioning the distal end of the at least one electrode lead so that the electrodes are adjacent at least one nerve in a patient;using a subcutaneous lead connector plug comprising a housing electrically connected to the proximal end of the at least one electrode lead and defining at least one lead connection port and at least one anchor point carried by the housing, positioning the housing along with the proximal end of the at least one electrode lead inside the patient beneath the patient's skin;connecting the at least one anchor point to tissue beneath the patient's skin;using a first generator lead having a distal end and a proximal end, plugging the distal end of the first generator lead into the at least one lead connector port to electrically connect the distal end of the second lead with the at least one lead connector port; ...

SYSTEM FOR TRANSMITTING ELECTRICAL CURRENT TO A BODILY TISSUE

In some embodiments, an apparatus includes a substantially rigid base and a flexible substrate. The substantially rigid base has a first protrusion and a second protrusion, and is configured to be coupled to an electronic device. The flexible substrate has a first surface and a second surface, and includes an electrical circuit configured to electronically couple the electronic device to at least one of an electrode a battery, or an antenna. The flexible substrate is coupled to the base such that a first portion of the second surface is in contact with the first protrusion. A second portion of the second surface is non-parallel to the first portion. 1. An apparatus , comprising:a rigid base having a protrusion, the base configured to be coupled to an electronic device; anda flexible substrate having a first surface and a second surface and including an electrical circuit configured to electronically couple the electronic device to an antenna, the antenna coupled directly to the flexible substrate, the flexible substrate coupled to the base such that a first portion of the second surface is in contact with the protrusion, a second portion of the second surface is non-parallel to the first portion.2. The apparatus of claim 1 , wherein at least a first portion of the flexible substrate is disposed within a first slot defined by the base claim 1 , at least a second portion of the flexible substrate is disposed within a second slot defined by the base claim 1 , the first slot different than the second slot.3. The apparatus of claim 1 , wherein the base defines a plurality of slots claim 1 , each slot of the plurality of slots configured to receive a portion of the flexible substrate.4. The apparatus of claim 1 , wherein:a first portion of the first surface of the flexible substrate includes at least a portion of the electrical circuit, the portion of the electrical circuit configured to be in electrical communication with an electrical contact disposed on a first portion ...

SUB-EPIDERMAL ELECTRIC WARNING DEVICE

A sub-epidermal electric warning device has electrodes penetrating through the patient's epidermis and bipolar electric warning signals are transmitted to the sub-epidermal tissue by these electrodes. A device for surveillance of vital signs, analyte levels, or treatment parameters is using a sub-epidermal electric warning device for notifying the patient in situations requiring intervention. 1. A sub-epidermal electric warning device , comprising:electrodes to penetrate through a patient's epidermis into sub-epidermal tissue; andcircuitry to transmit unipolar voltage pulses to the electrodes, the unipolar voltage pulses to create bipolar current pulses of alternating positive and negative polarity in the sub-epidermal tissue.2. The sub-epidermal warning device according to claim 1 , wherein:the electrodes are electrically connected to each other to have a same potential during a portion of the unipolar voltage pulses.3. The sub-epidermal warning device according to claim 2 , wherein:one of the electrodes is grounded, and another of the electrodes is electrically connected to a power source during another portion of the unipolar voltage pulses which is different than said portion of the unipolar voltage pulses.4. The sub-epidermal warning device according to claim 3 , wherein:the unipolar voltage pulses include a rising edge and a falling edge,when the unipolar voltage pulses are at the rising edge, the bipolar current pulses have a first polarity, andwhen the unipolar voltage pulses are at the falling edge, the bipolar current pulses transition to a second polarity that is opposite to the first polarity.5. The sub-epidermal warning device according to claim 1 , wherein:the unipolar voltage pulses include a rising edge and a falling edge,when the unipolar voltage pulses are at the rising edge, the bipolar current pulses have a first polarity, andwhen the unipolar voltage pulses are at the falling edge, the bipolar current pulses transition to a second polarity that ...

Article and Method for Treating Diabetic Peripheral Neuropathy

Articles and methods for non-invasively treating peripheral neuropathy via transcutaneous electrical stimulation of target nerve tissue are described. An exemplary article includes a support on which an electrode pair is positioned; a controller attached to the electrode pair via one or more leads; and a power supply connected to the controller. The article delivers electrical stimulation to the target nerve tissue via the electrode pair at a level sufficient to initiate vasodilation of vasculature within or adjacent the tissue. Meanwhile, the method includes positioning at least one electrode pair adjacent an area of skin overlying or in close proximity to the target nerve tissue and delivering electrical stimulation to the tissue via the electrode pair. The electrical stimulation is delivered at a level sufficient to initiate vasodilation of vasculature within or adjacent the tissue. An implantable system and method for treating peripheral neuropathy via percutaneous electrical stimulation are also described. 1. An article for transcutaneously applying electrical stimulation to target nerve tissue to treat a patient having peripheral neuropathy , the article comprising:a support on which at least one electrode pair is positioned;a pulse generator attached to the at least one electrode pair via one or more leads; anda power supply connected to the pulse generator, wherein the article is configured to deliver electrical field stimulation to the target nerve tissue via the at least one electrode pair at a level sufficient to initiate vasodilation of vasculature within or adjacent the target nerve tissue, wherein the vasculature is responsible for perfusing the target nerve tissue.2. The article of claim 1 , wherein the power supply is connected to the support.3. The article of claim 1 , wherein the support is a wrap claim 1 , a sock claim 1 , a glove claim 1 , or a finger cot.4. The article of claim 3 , wherein the wrap claim 3 , the sock claim 3 , the glove or the ...

RAPID DESTRUCTION OF MALIGNANT TUMORS BY EXCITOTOXICITY AND OSMOTIC-SHOCK MEDICAL TACTICS

A process, method, and devices thereof for the rapid destruction of cancer tumor(s) which are made up of thousands to millions of living malignant cancer cells. Such an approach seeks to kill said tumor(s) by causing apoptosis or excitotoxicity and/or osmotic-shock within a human or animal for medical treatment. 1. A system for the rapid destructions of a cancer comprising a tumor , said system comprising:an electronic device for shutting down an operational signal system associated with a tumor in a body, said electronic device providing signals that were reprogrammed from recorded signals of an intrinsic cellular electrical pattern associated with the same type of tumor as said tumor in said body.2. The system of further comprising:a reaction chamber that encloses said tumor in a water-tight sealed non-metallic compartment, wherein said reaction chamber is sealed during a cancer killing process with respect to said tumor; andat least one reactive material employed within said reaction chamber to destroy said tumor, wherein arterial blood vessels feeding said tumor are clamped during said medical procedure to prevent contamination of other body structures by said at least one reactive material used in said reaction chamber.3. The system of wherein said at least one reactive material comprises saturated calcium C++ compounds.4. The system of wherein said at least one reactive material comprises at least one of: de-ionized and/or ionized water claim 2 , and glutamate transporters that can accommodate excitotoxic reaction pathways.5. The system of wherein said at least one reactive material comprises saturated calcium C++ compounds and de-ionized water.6. The system of wherein said at least one reactive material comprises saturated calcium C++ compounds and ionized water.7. The system of wherein said at least one reactive material comprises saturated calcium C++ compounds and glutamate transporters that accommodate excitotoxic reaction pathways.8. The system of ...

TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION ELECTRODE NEEDLE AND TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION DEVICE

The present disclosure provides a TENS electrode needle and a TENS device. The TENS electrode needle includes: a needle handle having a first electrode and a second electrode for providing pulse current signals with different polarities are arranged; and at least one first needle body and at least one second needle body. Each of the first needle body and the second needle body includes a first end and a second end. The first end of the first needle body is electrically connected to the first electrode, and the first end of the second needle body is electrically connected to the second electrode, so as to form an electrical field between the second end of the first needle body and the second end of the second needle body. 1. A transcutaneous electrical nerve stimulation (TENS) electrode needle , comprising:a needle handle having a first electrode and a second electrode for providing pulse current signals with different polarities; andat least one first needle body and at least one second needle body;wherein each of the first needle body and the second needle body comprises a first end and a second end; andwherein the first end of the first needle body is electrically connected to the first electrode, and the first end of the second needle body is electrically connected to the second electrode, so as to form an electrical field between the second end of the first needle body and the second end of the second needle body.2. The TENS electrode needle according to claim 1 , wherein a length of the first needle body is greater than a length of the second needle body.3. The TENS electrode needle according to claim 2 , wherein:the second end of the first needle body is of a pointed shape for piercing into skin; andthe second end of the second needle body comprises an electrode ring attached onto a surface of the skin, and the first needle body is inserted through the electrode ring, so as to form the electrical field between the second end of the first needle body and the ...

TUMOR THERAPY

Described are a system and method that “reads” cancer tumors real time and custom delivers individualized bioelectric therapy to the patient. For example, the system reads a cancer tumor, and based upon this read, delivers to the subject “a confounding signal” to jam communication within that tumor. A cancer tumor may change its communication patterns and the therapy is designed to change with these patterns, attempting to always jam the relevant communication signaling pathway. The described system includes parameters not tied to communication jamming, which should also be customized to induce apoptosis to the cancer tumor. Such parameters include signals for starving a cancer tumor of blood supply and signals for changing the cancer tumor's surface proteins and/or charge so that the immune system attacks the cancer tumor. 1. A method of treating a subject having a cancer tumor , the method comprising:reading the cancer tumor real time; andcustom delivering individualized bioelectric therapy to the subject and the cancer tumor in response to the reading.2. The method according to claim 1 , wherein the individualized bioelectric therapy is delivered to the subject by a device comprising:a probe for determining a resident electrical signal found in the cancer tumor;a computer system comprising a processor for modifying each resident electrical signal to form at least one confounding electrical signal unique to each resident electrical signal, and data storage for all confounding electrical signals; anda probe for applying the confounding electrical signals to the cancer tumor.3. The method according to claim 1 , further comprising:re-reading the cancer tumor; anddelivering revised individualized bioelectric therapy to jam communication signaling within the cancer tumor based upon changes in communication patterns of the cancer tumor after the custom delivery of the individualized bioelectric therapy.4. The method according to claim 3 , wherein jamming of ...

REGULATION OF THALAMIC ACTIVITY FOR CONTROL OF AGGRESSION

War of aggression, the root cause of which exists in the mind, produces suffering to constituents and their leaders. Multiple sites in the human brain are associated with aggression; however, a universal site responsible for all aggressive actions has not been found. Electrical stimulation of the brain has changed aggressive behavior, and electrical stimulation in some instances can overcome voluntary behavior. Of the many methods to stimulate the brain remotely and modify aggressive behavior, stimulation of the senses of touch, sight and/or sound is advantageous since it bypasses the blood brain barrier and the electrical impedance of soft tissues and bone overlying the brain. Stimulation of the senses produces waves comprised of action potentials in the thalamus that can interfere or entrain existing action potential waves. The waves from stimulation have the potential to discriminate existing electrical activity of sites in the brain associated with aggressive behavior. 1. A method to decrease aggressive behavior in a human by remote stimulation of the senses in said human , causing interference of waves of thalamic action potentials.2. The method of where the sense is touch.3. The method of where the sense is sight.4. The method of where the sense is sound.5. A method to decrease aggressive behavior in a human by remote stimulation of the senses in said human claim 1 , causing entrainment of waves of thalamic action potentials.6. The method of where the sense is touch.7. The method of where the sense is sight.8. The method of where the sense is sound. NoneNoneWars of aggression trace the history of civilization, but war of aggression is not inevitable. According to archeologic findings, war has been a part of man's culture prior to the development of agriculture. Remains of mass burials associated with weapons and inflicted destruction of human bones are the best evidence that hunter-gatherer societies were involved with aggressive warfare.The establishment of ...

SYSTEMS AND METHODS TO PLACE ONE OR MORE LEADS IN TISSUE FOR PROVIDING FUNCTIONAL AND/OR THERAPEUTIC STIMULATION

Systems and methods make possible the placement of one or more electrode leads in a tissue region for providing functional and/or therapeutic stimulation to tissue. The systems and methods are adapted to provide the relief of pain. 1. A method to reduce and/or relieve pain in a painful region comprising:stimulating a peripheral nerve innervating the painful region via an electrode positioned near the peripheral nerve and outside of the painful region, wherein the stimulation comprises a frequency of between 1 and 300 Hz; andactivating the peripheral nerve to alleviate pain in the painful region without functional nerve stimulation at a motor point and without damaging the peripheral nerve.2. The method of claim 1 , wherein the frequency is between 4 and 20 Hz.3. The method of claim 1 , wherein the frequency is between 1 and 12 Hz.4. The method of claim 1 , wherein the frequency is 12 Hz.5. The method of claim 1 , wherein the frequency is 100 Hz.5. The method of claim 1 , wherein the stimulation comprises a pulse duration of between 1 and 200 μs.6. The method of claim 5 , wherein the pulse duration is between 5 and 100 μs.7. The method of claim 1 , wherein the stimulation comprises an intensity of between 0.1 and 40 mA.8. The method of claim 7 , wherein the intensity comprises 30 mA.9. The method of further comprising evoking paresthesia over at least a portion of the painful region.10. The method of claim 9 , wherein the paresthesia is evoked over all of the painful region.11. The method of claim 1 , wherein the stimulation comprises a pulse duration of between 5 and 100 μs claim 1 , the stimulation comprises an intensity of 30 mA and the frequency is 12 Hz.12. The method of further comprising evoking paresthesia over at least a portion of the painful region.13. A system to reduce and/or relieve pain in a painful region claim 11 , the system comprising:an electrode positioned near a peripheral nerve innervating the painful region and the electrode positioned outside ...

Applying Tumor Treating Fields (TTFields) Via Electrodes Embedded into Skull Implants

Tumors inside a person's head (e.g., brain tumors) can be treated using tumor treating fields (TTFields) by positioning capacitively coupled electrodes on opposite sides of the tumor, and applying an AC voltage between the electrodes. Unlike the conventional approach (in which all of the electrodes are positioned on the person's scalp) at least one of the electrodes is implemented using an implanted apparatus. The implanted apparatus includes a rigid substrate shaped and dimensioned to replace a section of the person's skull. At least one electrically conductive plate is affixed to the inner side of the rigid substrate, and a dielectric layer is disposed on the inner side of the conductive plate or plates. An electrically conductive lead is used to apply an AC voltage to the conductive plate or plates. 1. An apparatus comprising:a rigid substrate shaped and dimensioned to replace a section of a skull, the substrate having an inner side and an outer side;an electrically conductive plate having an inner side and an outer side, wherein the outer side of the plate is affixed to the inner side of the substrate;a dielectric layer disposed on the inner side of the plate; andan electrically conductive lead having an inner end and an outer end, wherein the inner end of the lead is disposed in electrical contact with the plate, wherein the lead passes through the substrate, and wherein the outer end of the lead is configured to accept an electrical signal from an external device.2. The apparatus of claim 1 , further comprising a temperature sensor positioned adjacent to the dielectric layer.3. The apparatus of claim 2 , further comprising at least one wire that passes through the substrate and terminates at the temperature sensor claim 2 , wherein the wire is configured to transmit an electrical signal from the temperature sensor to the external device.4. The apparatus of claim 3 , wherein the temperature sensor comprises a thermistor.5. The apparatus of claim 1 , wherein the ...

Systems, methods and devices for a skull/brain interface

Systems, methods and devices are disclosed for directing and focusing signals to the brain for neuromodulation and for directing and focusing signals or other energy from the brain for measurement, heat transfer and imaging. An aperture in the skull and/or a channel device implantable in the skull can be used to facilitate direction and focusing. Treatment and diagnosis of multiple neurological conditions may be facilitated with the disclosed systems, methods and devices.

System and method for reversing the effects of paralysis

A method and system for applying therapeutic stimulation to a patient stricken with paralysis or other condition. The inventive method includes the steps of: inserting an acupuncture needle against the spine of the patient and applying an electrical potential to the needle with a signal that mimics natural neural impulses in the body. The needle is located depending on the nature of the patient's condition. In the illustrative application, the needle is inserted against the ligamentum flavum of the patient's spine at L3. In the best mode, the patient's legs are moved during the application of the electrical potential. The inventive system is adapted to minimize a notch reaction and includes an electrode inserted into a tissue of the patient and a circuit for applying an electrical potential to the electrodes with a signal that mimics natural neural impulses in the body.

METHODS FOR IMPROVED TREATMENT OF OVERACTIVE BLADDER

Methods for providing therapy related to urological disorders. Particular embodiments of this technology relate to stimulation of lumbar spinal targets either alone or in combination with a sacral target or targets. In embodiments spinal roots are stimulated by partially or fully implanted stimulators to treat symptoms by producing bladder inhibition relative to that which occurs prior to stimulation. Embodiments also disclose improving nerve stimulation, including lumbar nerve root stimulation, using methods termed enhanced transcutaneous electrical stimulation (eTENS) since these enhance the inhibition or excitation of neural tissue. 1. A method for treating a patient suffering from symptoms of an overactive bladder comprising:implanting at least one stimulator adapted to be implanted in a patient;positioning said at least one stimulator adjacent to and configured to stimulate spinal nerve root targets L3 and L4;implanting a neurostimulator having at least one stimulation protocol configured to apply at least a first stimulation signal to the spinal nerve root targets; and,modulating patient bladder activity according to stimulation protocol parameters, in which the at least first stimulation signal includes a first signal selected to produce a desired modulation of bladder activity in the patient, whereby said overactive bladder is innervated.2. The method of wherein the step of modulating patient bladder activity includes selecting a first stimulation protocol having parameters to provide inhibition of bladder activity.3. The of in which the step of implanting the at least one stimulator includes the step of selecting the spinal root target responsive to assessment of patient data by a doctor or by an algorithm which indicates the spinal root target as producing therapeutic efficacy in the patient.4. The method of including the step of establishing an additional stimulator that is configured and located to stimulate a spinal nerve root target L2 to provide ...

Device and Implantation System for Electrical Stimulation of Biological Systems

The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements. 1. A method of implanting electrodes in a patient in order to treat gastroesophageal reflux disease , comprising:implanting a first electrode in an anterior proximal wall of an esophagus, wherein said first electrode is positioned axially along a length of said esophagus; andimplanting a second electrode proximate a right lateral wall of said esophagus, wherein said second electrode is positioned parallel and distal to said first electrode.2. The method of claim 1 , further comprising the steps of:connecting said first and second electrodes to a pulse stimulator configured to supply a stimulation pulse to said first and second electrodes; andoperating said first and second electrodes in combination to deliver electrical stimulation to at least partly normalize a function of a lower esophageal sphincter (LES) of said patient post-stimulation.3. The method of claim 2 , wherein said stimulation pulse has a pulse amplitude equal to or less than 15 mAmp.4. The method of claim 2 , wherein said pulse stimulator is configured to detect a LES pressure derived from an impedance sensor claim 2 , piezoelectric sensor claim 2 , or electrical activity based sensor.5. The method of claim 1 , wherein said second electrode is separated from said first electrode by a distance equal to or less than 1.5 cm.6. The method of claim 1 , wherein said first electrode and second electrode are each ...

LYMPHATIC SYSTEM NEUROMODULATION AND USES THEREOF

Methods are disclosed for preventing systemic infection or controlling metastases or providing a vaccine adjuvant in a subject, the methods comprising stimulating one or more peripheral nerves innervating one or more lymph nodes of the subject. 1. A method of inhibiting systemic infection by infectious pathogens or controlling metastases or providing a vaccine adjuvant in a subject , the method comprising stimulating one or more peripheral nerves innervating one or more lymph nodes of the subject.2. The method of claim 1 , wherein stimulation is applied in an amount and manner effective to reduce antigen flow through lymph nodes.3. The method of claim 1 , wherein stimulation constrains infectious pathogens from traveling through the lymphatic system leading to systemic infection claim 1 , wherein unconstrained travel leads to systemic infection.4. The method of claim 1 , comprising stimulating nerves innervating lymph nodes draining the site of an infection.5. The method of claim 1 , wherein nerve stimulation is applied after an injury to the skin of the subject claim 1 , such as a large or deeply penetrating injury.6. The method of claim 1 , wherein the infectious pathogens are bacteria.7. The method of claim 1 , wherein stimulating nerves innervating lymph nodes draining the site of a penetrating injury to the subject prevents bacteremia and sepsis.8. The method of claim 1 , wherein stimulation restricts tumor cells and micrometastases from traveling through the lymphatic system claim 1 , wherein unrestricted travel to recolonization of cancer cells in forming a secondary tumor.9. The method of claim 1 , comprising stimulating nerves innervating lymph nodes draining the site of a primary tumor.10. The method of claim 1 , wherein stimulation increases antibody production to an antigen present in a vaccine.11. The method of claim 1 , wherein femoral and sciatic nerves are stimulated in the popliteal fascia.12. The method of claim 1 , wherein electrical stimulation ...

Multi-functional electro-spoon needle therapeutic apparatus

Disclosed is a multi-functional electro-spoon needle therapeutic apparatus, which includes a top cover, locating pieces, a fixed lid, a rear cover, electro-spoon needles and an adjustment mechanism, wherein the locating pieces are respectively mounted on the top cover and the rear cover, and each locating piece is provided with a long groove; the fixed lid is respectively fixed on the top cover and the rear cover so as to respectively hold the locating pieces between the top cover and the fixed lid and between the rear cover and the fixed lid; the rear cover is arranged behind the top cover and connected to the top cover via the adjustment mechanism; and the electro-spoon needles are mounted in the long grooves of the locating pieces and can move along the long grooves. The apparatus has a simple structure, so a patient can perform acupuncture by himself.

PERCUTANEOUS TIBIAL NERVE STIMULATOR

A tibial nerve stimulation device including a percutaneous electrode for inserting adjacent a stimulation site of a patient and a neurostimulator unit attachable to a transcutaneous electrode configured to be applied to skin adjacent the stimulation site. The neurostimulator unit includes a pulse generator electrically coupled to the percutaneous needle electrode and transcutaneous electrode and a microcontroller in communication with the pulse generator for monitoring a number of available treatment credits and activating the pulse generator, each available treatment credit corresponding to a treatment session and the pulse generator operable to be activated for performing the treatment session when the number of available treatment credits is at least one. A computer system is operable to communicate with the microcontroller of the neurostimulator unit for receiving a treatment credit request and transmitting the number of treatment credits purchased to the microcontroller of the neurostimulator unit. 1. A nerve stimulation system comprising: a pulse generator for electrically coupling to a percutaneous needle electrode having a leading end for inserting adjacent a stimulation site of a patient and a transcutaneous electrode configured to be applied to skin adjacent the stimulation site of the patient, and', 'a microcontroller in communication with the pulse generator for monitoring a number of available treatment credits and activating the pulse generator, each available treatment credit corresponding to a treatment session and the pulse generator operable to be activated for performing the treatment session when the number of available treatment credits is at least one, the pulse generator generating current pulses during the treatment session that pass between the transcutaneous electrode and the percutaneous needle electrode for providing stimulation to the stimulation site; and, 'a neurostimulator unit includinga computer system operable to communicate with ...

Systems, devices, and methods for monitoring and analyzing research animal behavior before, during and after brain electrical stimulation

Described are systems, devices and methods for facilitating the delivery of stimulation to, and the monitoring and recording of physiological signals (e.g., electroencephalographic signals) from a research subject. Devices include a headmount that includes a cranial frame and a headstage, and a connection between the headmount and external equipment used for stimulation, monitoring, and/or recording that is robust physically and electrically to optimize stimulation, monitoring and recording even while the subject remains ambulatory. In some embodiments, a hinged headmount allows the configuration to be easily manipulated during attachment and any subsequent adjustment or reattachment procedures and permits easy access to any wires or other components implanted in the subject. In some embodiments, a flexible cable extends out from the headmount at an acute angle relative to a horizontal plane of the headmount, to optimize strain relief as the subject moves about while attached to any stimulation, monitoring and/or recording equipment.

SYSTEMS AND METHODS FOR PERIPHERAL NERVE STIMULATION TO TREAT TREMOR WITH DETACHABLE THERAPY AND MONITORING UNITS

A system and method for providing therapy to a patient can include a monitoring unit and a therapy unit. The monitoring unit can have a user interface and one or more sensors to measure patient data. The therapy unit can have a stimulator for generating electrical stimulation and a microcontroller for controlling the generation of the electrical stimulation based on the measured patient data. 129-. (canceled)30. A system for stimulating at least one nerve of a patient , the system comprising: 'a detachable therapy unit comprising:', 'a band comprising a first surface configured to contact skin of the patient, and comprising at least two skin electrodes, and a second surface opposite the first surface, the second surface comprising at least two receiving contacts and the band further comprising a first electrical circuit configured to be in electrical communication with both the at least two skin electrodes and the at least two receiving contacts; and'}a second electrical circuit;a stimulator configured to generate an electrical stimulation, the stimulator in electrical communication with the second electrical circuit;at least two therapy unit electrodes that are configured to receive the electrical stimulation from the stimulator, the at least two therapy unit electrodes configured to connect to the at least two receiving contacts, thereby forming an electrical pathway between the stimulator and the at least two skin electrodes;a controller configured to control the generation of the electrical stimulation by the stimulator; anda power source in electrical communication with the second electrical circuit;wherein the detachable therapy unit is configured to be reversibly attached to the band.31. The system of claim 30 , wherein the band further comprises one or more identifiers.32. The system of claim 31 , wherein the one or more identifiers are associated with stimulation parameters and/or usage life information.33. The system of claim 30 , further comprising a base ...

Device and method to selectively and reversibly modulate a nervous system structure to inhibit pain

The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neural- and non-neural tissue of the nervous structure, inhibiting pain while preserving other sensory and motor function, and proprioception.

EXTERNAL PULSE GENERATOR DEVICE AND AFFIXATION DEVICE FOR TRIAL NERVE STIMULATION AND METHODS OF USE

Systems and methods for providing a trial neurostimulation to a patient for assessing suitability of a permanently implanted neurostimulation are provided herein. In one aspect, a trial neurostimulation system includes an EPG affixation device that secures the EPG to the patient when connected to a lead extending through a percutaneous incision to a target tissue location, while allowing for ready removal of the EPG for charging or bathing. In another aspect, the system includes an EPG provided with a multi-purpose connector receptacle through which the the EPG can deliver neurostimulation therapy to an implanted lead or the EPG can be charged. In yet another aspect, the EPG can include a multi-purpose connector receptacle that is alternatingly connectable with a plurality of differing connector to facilitate differing types of therapies with one or more neurostimulation devices, ground patches or various other devices, such as charging or testing devices. 1. An external pulse generator comprising:a pulse generator electrically configured for generating neurostimulation pulses along a plurality of stimulation channels;a battery electrically coupled to the pulse generator;an outer housing enclosing the pulse generator and battery;a multi-pin connector electrically coupleable to the pulse generator through the external cable, wherein a plurality of pins of the multi-pin connector correspond to the plurality of stimulation channels; andan actuatable user interface feature disposed on the housing and configured to facilitate programming of the external pulse generator.2. The external pulse generator of claim 1 , further comprising:an external cable extending from the housing, wherein the external cable is permanently attached to the housing such that any electrical connections between the multi-pin connector and the pulse generator are permanently sealed.3. The external pulse generator of claim 2 , wherein the external cable is between 1 inch and 12 inches in length.4. ...

Random pulsed high frequency therapy

A method and apparatus for modifying a function of tissue can include the application of an electromagnetic signal output to tissue cells. The electromagnetic signal output can have a waveform with bursts of signal output amplitude that produces fields in the tissue during the burst on-time that can modify cell components. The on-time periods are followed by off-time periods of low signal output amplitude which produce lesser modification effects on cell components. The on-time periods have time durations that are non-predetermined and random. The rate of on-time bursts can be regular, and in one example periodic. In one example, the waveform has amplitudes during the on-time periods and durations of on-time periods that causes elevation of the temperature of tissue that exceeds the lethal temperature levels of 45 to 50° C. 1. An apparatus for altering a function of living tissue comprising:an electrode; anda signal generator coupled to the electrode to generate an electrical signal output to be applied to the living tissue through the electrode, the electrical signal output having an interrupted waveform having bursts of on-time periods of a high frequency carrier frequency component, the on-time periods having non-predictable and uncorrelated time durations, each of the on-time periods being followed by off-time periods, the amplitude of the electrical signal output during the off-time periods being low relative to the amplitude of the electrical signal output of the on-time period, and the bursts of the on-time periods commencing at a regular rate, such that the application of the electrical signal output to the living tissue for a sufficient treatment time will result in alteration of a function of the living tissue.2. The apparatus of claim 1 , wherein the waveform results in an average temperature in the living tissue that is below the lethal temperature range of about 45 to 50° C.3. The apparatus of claim 1 , wherein the waveform results in an average ...

COMMUNICATION SYSTEM AND METHODS FOR FULLY IMPLANTABLE MODULAR COCHLEAR IMPLANT SYSTEM

Cochlear implant systems can include a cochlear electrode, a stimulator in electrical communication with the cochlear electrode, and a signal processor in communication with the stimulator. The signal processor can include circuitry and a can surrounding and housing the circuitry. The signal processor can further include a first impedance between the circuitry and the can in order to reduce unintended electrical communication between the cochlear electrode and the circuitry of the signal processor. Other components can similarly include impedance between their respective cans and circuitry to prevent such undesired communication. Components can communicate with one another via bidirectional communication. Communication can include communication of signals and inverted signals to reduce net charge flow through the wearer's body. 1. A cochlear implant system comprising:a cochlear electrode;a stimulator in electrical communication with the cochlear electrode;a signal processor in communication with the stimulator, the signal processor including circuitry, a can surrounding and housing the circuitry, and a first impedance between the circuitry and the can to reduce unintended electrical communication between the cochlear electrode and the circuitry of the signal processor;an input source in communication with the signal processor; andan implantable battery and/or communication module, the implantable battery and/or communication module being configured to provide electrical power to the signal processor and including circuitry, a can surrounding and housing the circuitry, and a second impedance between the circuitry and the can to reduce unintended electrical communication between the cochlear electrode and the circuitry of the implantable battery and/or communication module; whereinthe signal processor is in communication with the implantable battery and/or communication module via a first lead.2. The implant system of claim 1 , wherein the signal processor is coupled ...

DEVICES AND METHODS FOR DELIVERY OF ELECTRICAL CURRENT FOR PAIN RELIEF

Device/system that provides pain relief by delivering stimulation that neither generates action potentials nor completely blocks neural transmission (in the peripheral nerve). The present teachings provide relief by modulating release of neurotransmitters in peripheral nerves to cause neuromodulation at the level of the peripheral nerve (modulation of neural signals in the peripheral nerve). The present teachings provide relief by modulating release of neurotransmitters in peripheral nerves to cause neuromodulation at the level of the peripheral nerve (modulation of neural signals in the peripheral nerve) to alter the frequency of physiologically generated neural transmission. 1. A method of treating pain comprising:delivering electric current altering transmission and/or production of action potentials in one nerve tissue selected from a nerve cell body, dendrites, axons, axon hillocks, and/or other nerve fibers without directly stimulating an action potential in the nerve tissue; andwherein the electric current causes at least one of: (a) changes to a frequency of one or more action potentials; (b) changes in probability of one or more action potentials occurring; (c) changes in excitability of at least one nerve; (d) changes to conduction velocity, shape, form, features, interpulse interval, period, rate, coefficient of variation, or duration of one or more action potentials and (e) changes to timing, spacing, or pattern of one or more action potentials or trains of action potentials.2. The method of claim 1 , wherein the electrical current does not cause a perception of parenthesis.3. The method of wherein the electrical current does not block or interrupt efferent signals and motor nerve signals.4. The method of wherein the electrical current alters action potentials in the neural targets via activation claim 1 , inactivation claim 1 , excitation claim 1 , or suppression of non-neural tissue.5. The method of wherein the non-neural tissue is a glial cell.6. The ...

Electrode Assembly for Spinal Cord Stimulation

An electrode assembly for stimulation of a spinal cord within a spinal canal, the spinal canal containing a dura mater, the assembly incorporating a base, a lateral arm extending from the base; a ventral series of electrodes attached to base and to the lateral arm; a dorsal series of electrodes attached to the base and to the lateral arm; ventral and dorsal matrices of electrical conductors respectively communicating electrically with the ventral and dorsal series of electrodes; and an electric pulse generator for electrifying the ventral and dorsal conductors, the generator being adapted for exclusively electrifying the ventral matrix of electrical conductors, and for alternatively exclusively electrifying the dorsal matrix of electrical conductors. 1: An electrode assembly for stimulation of a spinal cord within a spinal canal , the spinal canal containing a dura mater dorsally overlying the spinal cord , said assembly comprising:(a) a base having an anterior and posterior ends, having lateral and oppositely lateral sides, and having dorsal and ventral sides;(b) a lateral arm having anterior and posterior ends, having dorsal and ventral sides, and having proximal and distal ends, wherein said arm's proximal end is fixedly attached to the base's lateral side;(c) a ventral series of electrodes fixedly attached to a surface selected from the group consisting of the base's ventral side and the lateral arm's ventral side;(d) a dorsal series of electrodes fixedly attached to a surface selected from the group consisting of the base's dorsal side and the lateral arm's dorsal side;(e) ventral and dorsal matrices of electrical conductors, said matrices respectively communicating electrically with the ventral and dorsal series of electrodes; and(f) means for electrifying the ventral and dorsal matrices of electrical conductors, said means being adapted for, upon a rotation stopping contact by the distal end of the lateral arm against the dura mater, exclusively electrifying ...

Omnidirectional Deployable Multichannel Neural Electrode System

A neural probe system having a single guide tube that is inserted into neural tissue and from which a number of neural probes can be deployed is described. Each probe is deployable into tissue along a desired trajectory. This is done by supporting the electrode array on a spring tape-type carrier that maintains axial stiffness once the neural probe has deployed out a channel in the guide tube. That way, a target neural tissue is bounded by an increased number of neural probes while minimizing trauma to surrounding body tissue.

APPARATUS AND METHOD FOR POSITIONING, IMPLANTING AND USING A STIMULATION LEAD

An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath. 1. An introducer system comprising:an electrical stimulus generator;an open-coiled stimulation lead having a conductive distal anchor and a proximal end in communication with the stimulus generator;a needle assembly comprising a first needle comprising an outer sheath having an outer circumference and defining a bore wherein the outer circumference is not continuous, a second needle carried within the bore during positioning and testing of the open-coiled stimulation lead, and at least one test electrode positioned along the outer circumference and in electrically communication with the stimulus generator; anda third needle comprising a third needle sheath having a third needle outer circumference and defining a third needle bore wherein the open-coiled stimulation lead is carried within the third needle sheath, whereby the open-coiled stimulation lead and the third needle sheath replace the second needle in preparation for deployment of the open-coiled stimulation lead.2. The introducer system of claim 1 , wherein upon activation of a test mode of the stimulus generator claim 1 , the at least one test electrode delivers test stimulation at one or more desired positions.3. The introducer system of claim 2 , wherein the needle assembly is repeatedly repositionable to test stimulation without requiring the open-coiled stimulation lead and ...

METHODS FOR CATHETER-BASED RENAL NEUROMODULATION

Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, monopolar neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such monopolar neuromodulation is performed bilaterally. 125-. (canceled)26. A method for catheter-based renal neuromodulation , the method comprising:intravascularly positioning a catheter in a reduced profile delivery configuration within a renal artery of a human patient and adjacent to renal nerves that innervate a kidney of the patient;transforming an expandable electrode at a distal region of the catheter from the reduced profile delivery configuration to a treatment configuration,wherein the expandable electrode comprises a helical configuration, and wherein, in the treatment configuration, the expandable electrode is sized and shaped such that the helical electrode contacts an inner wall of the renal artery of the patient; anddelivering an electric field between the expandable electrode and a ground pad coupled to an exterior of the patient, thereby thermally inhibiting neural communication along the renal nerves,wherein delivering the electric field and thermally inhibiting neural communication along the renal nerves results in a therapeutically beneficial reduction in blood pressure of the patient.27. The method of wherein the helical member comprises a self-expanding material.28. The method of wherein the helical member comprises nitinol.29. The method of wherein the catheter further comprises an expandable element proximal of the expandable electrode claim 26 , and wherein the method further comprises expanding the expandable element into ...

NEUROSTIMULATOR INTERCONNECTION APPARATUS, SYSTEM, AND METHOD

In various examples, an apparatus includes a neurostimulation interconnection apparatus including an elongate lead body including a lead proximal end and a lead distal end. The lead proximal end includes a first connector portion. A stimulation device includes a header. The header includes a second connector portion including a shape complementary to a shape of the first connector portion. The first connector portion is mateably engageable with the second connector portion, wherein one of the first connector portion and the second connector portion includes a plurality of pins and the other of the first connector portion and the second connector portion includes a plurality of sockets. There are an equal number of sockets and pins, wherein, with the first connector portion mateably engaged with the second connector portion, the pins align and electrically couple with the sockets. 1. (canceled)2. A neurostimulation interconnection apparatus comprising:an elongate lead body including a lead proximal end and a lead distal end, the lead proximal end including a first connector portion; anda stimulation device including a header, the header including a second connector portion including a shape complementary to a shape of the first connector portion, the first connector portion being mateably engageable with the second connector portion, wherein at least one of the first connector portion and the second connector portion includes a substrate including a plurality of connectors disposed on the substrate, and the other of the first connector portion and the second connector portion includes a plurality of conductor tabs, there being an equal number of connectors and conductor tabs, wherein, with the first connector portion mateably engaged with the second connector portion, the connectors align and electrically couple with the conductor tabs.3. The neurostimulation interconnection apparatus of claim 2 , wherein the plurality of connectors includes a plurality of printed ...

SYSTEMS AND METHODS FOR PROVIDING AND COORDINATING VAGUS NERVE STIMULATION WITH AUDIO THERAPY

A method of providing vagus nerve stimulation to a user is provided. The method includes the step of prompting, via a first audio cue emitted by an earpiece worn by a user, the user to inhale at a first point in time. The method may further include the step of prompting, via a second audio cue emitted by the earpiece, the user to exhale at a second point in time. The method may further include the step of stimulating a vagus nerve of the user with a first electrical signal generated by the earpiece at the second point in time. The first electrical signal may be applied to a concha of an ear of the user. The first electrical signal may be applied to an ear canal of the user. The first electrical signal may be applied to a tragus of the user. 1. A method of providing vagus nerve stimulation to a user , comprising the steps of:prompting, via a first audio cue emitted by an earpiece worn by a user, the user to inhale at a first point in time;prompting, via a second audio cue emitted by the earpiece, the user to exhale at a second point in time; andstimulating a vagus nerve of the user with a first electrical signal generated by the earpiece at the second point in time.2. The method of claim 1 , further comprising the steps of:prompting, via a third audio cue emitted by the earpiece, the user to inhale at a third point in time;prompting, via a fourth audio cue emitted by the earpiece, the user to exhale at a fourth point in time; andstimulating the vagus nerve of the user with a second electrical signal generated by the earpiece at the fourth point in time.3. The method of claim 2 , wherein a time period between the third and fourth points in time is greater than a time period between the first and second points in time.4. The method of claim 1 , wherein the first audio cue is an inhalation recording and the second audio cue is an exhalation recording.5. The method of claim 1 , further comprising the step of measuring claim 1 , via a sensor claim 1 , a biometric property ...

METHOD OF TREATING OR ALLEVIATING A PATIENT WITH INCONTINENCE

Methods of treating or alleviating a patient with incontinence are disclosed. In one embodiment, a method comprises applying a transcutaneous electrical stimulation using an electrode to a limb of the patient and stimulating a nerve running through the limb and emanating from a sacral nerve of the patient through the transcutaneous electrical stimulation. The transcutaneous electrical stimulation causes a signal to propagate to a target nerve in the pelvic floor of the patient and results in a reduction of symptoms associated with incontinence. 1. A method of treating or alleviating a patient with incontinence comprising:applying a transcutaneous electrical stimulation using an electrode to a limb of the patient; andstimulating a nerve running through the limb and emanating from a sacral nerve of the patient through the transcutaneous electrical stimulation, wherein the transcutaneous electrical stimulation causes a signal to propagate to a target nerve in the pelvic floor of the patient and results in a reduction of symptoms associated with incontinence.2. The method of claim 1 , wherein the nerve emanating from the sacral nerve is a tibial nerve.3. The method of claim 1 , wherein the nerve emanating from the sacral nerve is a popliteal nerve.4. The method of claim 1 , wherein the transcutaneous electrical stimulation is pulsed.5. The method of claim 1 , wherein the incontinence is urinary incontinence.6. The method of claim 1 , wherein the incontinence is fecal incontinence.7. The method of claim 1 , further comprising detecting a muscle contraction via at least one sensor in response to the transcutaneous electrical stimulation applied to the limb.8. The method of claim 1 , wherein the nerve emanating from the sacral nerve runs through the limb of the patient.9. The method of claim 1 , wherein the transcutaneous electrical stimulation is applied to a popliteal fossa region of the patient.10. A method of treating a subject with urinary incontinence comprising: ...

Electrical acuptuncture eye treatment

A system and method for eye treatment. The system and method utilize an electro acupuncture stimulator. The electro acupuncture stimulator includes a positive lead and a negative lead. The system further includes a pair of first needles, a second needle and a diode. The pair of first needles are electrically connected to one of the positive lead and the negative lead. The diode is electrically connected to the other of the positive lead and the negative lead. The second needle is electrically connected to the diode.

METHODS AND DEVICES FOR PERFORMING ELECTRICAL STIMULATION TO TREAT VARIOUS CONDITIONS

In certain variations, systems and/or methods for electromagnetic induction therapy are provided. One or more ergonomic or body contoured applicators may be included. The applicators include one or more conductive coils configured to generate an electromagnetic or magnetic field focused on a target nerve, muscle or other body tissues positioned in proximity to the coil. One or more sensors may be utilized to detect stimulation and to provide feedback about the efficacy of the applied electromagnetic induction therapy. A controller may be adjustable to vary a current through a coil to adjust the magnetic field focused upon the target nerve, muscle or other body tissues based on the feedback provide by a sensor or by a patient. In certain systems or methods, pulsed magnetic fields may be intermittently applied to a target nerve, muscle or tissue without causing habituation. 1. (canceled)2. A method of treating dysmenorrhea or menstrual cramps , comprising:non-invasively positioning a first portion of a patient's body relative to an electrical stimulator such that a branch of a posterior tibial nerve within the first portion of the body is directly targeted by the electrical stimulator;passing a current through the electrical stimulator; anddelivering an electrical stimulus from the electrical stimulator to the branch of the posterior tibial nerve such that the branch directly receives the electrical stimulation to treat dysmenorrhea or menstrual cramps.3. The method of wherein non-invasively positioning comprises positioning an electrode patch in communication with the electrical stimulator upon a foot of the patient.4. The method of further comprising detecting a muscular response caused by an electrical conduction or stimulation of the branch of the posterior tibial nerve.5. The method of wherein delivering the electrical stimulus comprises activating the electrical stimulator for a duration of about 30 minutes per week to treat the patient.6. The method of further ...

METHOD, SYSTEM, AND APPARATUS FOR DERMATOLOGICAL TREATMENT

An apparatus for treating dermatological tissue, including at least two pins configured to be inserted in dermatological tissue to deliver electromagnetic energy to target dermatological tissue, and an electrical signal generator electrically coupled to the at least two pins, and creating a pulsed electrical signal across the at least two pins. 1. An apparatus for treating dermatological tissue , comprising:at least two pins configured to be inserted in dermatological tissue to deliver electromagnetic energy to target dermatological tissue; andan electrical signal generator electrically coupled to the at least two pins, and creating a pulsed electrical signal across the at least two pins.2. The apparatus of claim 1 , wherein the at least two pins have a voltage level between 20 Vrms and 250 Vrms.3. The apparatus of claim 1 , wherein the electrical signal generator repetitively creates an electrical signal across the at least two pins for 10 msec to 300 msec.4. The apparatus of claim 1 , wherein the pulsed electrical signal has at least one delay time.5. The apparatus of claim 1 , wherein the electrical signal generator repetitively creates an electrical signal across the at least two pins to thermally damage the dermatological tissue.6. The apparatus of claim 1 , wherein the at least two pins form a bipolar configuration.7. The apparatus of claim 1 , wherein the pulsed electrical signal is periodic pulsed wave across the at least two pins for a predetermined time interval claim 1 , each pulse having a width.8. The apparatus of claim 1 , wherein the electrical signal generator repetitively creates an electrical signal across the at least two pins to form an electric field of Alternating Current (A.C.) between the at least two pins.9. The apparatus of claim 1 , wherein the electrical signal generator creates an electrical signal across the at least two pins having a frequency from 0.1 MHz to 100 MHz.10. The apparatus of claim 1 , wherein the apparatus may improve at ...

PERSONALIZED NETWORK SEARCHING

Personalized network searching, in which a search query is received from a user, and a request is received to personalize a search result. Responsive to the search query and the request to personalize the search result, a personalized search result is generated by searching a personalized search object. Responsive to the search query, a general search result is generated by searching the general search object. The personalized search result and the general search result are provided to a client device, an advertisement is selected based at least in part upon the personalized search object, and the advertisement, the personalized search result, and the general search result are displayed. 120.-. (canceled)21. A system , comprising:a first device comprising at least one processor and memory;an input interface of the first device;an output interface of the first device; receive, from a user, a modification to a set of objects identified by the first device;', 'synchronize the modification with at least one other device or system;', 'receive, via the input interface, a query;', an object from the set of objects modified via the first device;', 'an object from a first index; or', 'an object from a second index., 'present, through the output interface, responsive to the query, a combined search results set generated via one or more search sub-processes, the combined search results set including at least two of], 'an application program executed by the at least one processor to22. The system of claim 21 , comprising:the first device to transmit the indication of the modification to the system; andthe at least one other device to receive the indication of the modification to the set of objects from the system.23. The system of claim 21 , comprising:the first device to transmit the indication of the modification to the system; andthe system to synchronize the set of objects stored on the system based on the indication of the modification, and further synchronize the set of ...

HIGH VOLTAGE CONNECTORS FOR PULSE GENERATORS

An electrode connectable to a pulse generator is disclosed. The electrode includes therapeutic terminals configured to deliver the pulse to a patient, first and second electrical pulse inlet holes, and a first pulse input terminal. The first pulse input terminal is in the first electrical pulse inlet hole and is spaced apart from an entrance to the first electrical pulse inlet hole by more than about 2.5 cm. Also, first pulse input terminal is connected with one or more of the therapeutic terminals. The electrode also includes a second pulse input terminal, where the second pulse input terminal is in the second electrical pulse inlet hole and is spaced apart from an entrance to the second electrical pulse inlet hole by a distance greater than about 2.5 cm. Also, the second pulse input terminal is electrically connected with one or more of the therapeutic terminals. 1. An electrode electrically connectable to a pulse generator , wherein the electrode is configured to deliver a pulse generated by the pulse generator to a patient , the electrode comprising:a plurality of therapeutic terminals configured to deliver the pulse to the patient;first and second electrical pulse inlet holes;a first pulse input terminal, wherein the first pulse input terminal is in the first electrical pulse inlet hole and is spaced apart from an entrance to the first electrical pulse inlet hole by a distance greater than about 2.5 cm, and wherein the first pulse input terminal is electrically connected with one or more of the therapeutic terminals; anda second pulse input terminal, wherein the second pulse input terminal is in the second electrical pulse inlet hole and is spaced apart from an entrance to the second electrical pulse inlet hole by a distance greater than about 2.5 cm, and wherein the second pulse input terminal is electrically connected with one or more of the therapeutic terminals.2. The electrode of claim 1 , further comprising a guard configured to maintain a user's hand a ...

Methods and Apparatus for Bilateral Renal Neuromodulation

Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney. 154-. (canceled)55. A method for treatment of a hypertensive human patient , the method comprising:intravascularly positioning a catheter within a first renal artery associated with a first kidney of the patient;ablating renal nerves along the first renal artery via first ultrasound energy from the catheter;intravascularly positioning the catheter within a second renal artery associated with a second kidney of the patient; andablating renal nerves along the second renal artery via second ultrasound energy from the catheter,wherein ablating renal nerves along the first renal artery and ablating renal nerves along the second renal artery results in a therapeutically beneficial reduction in blood pressure of the hypertensive patient.56. The method of claim 55 , further comprising removing the catheter from the patient after delivering the first and second ultrasound energy to conclude the procedure.57. The method of wherein the first ultrasound energy is the same as the second ultrasound energy.58. The method of wherein the first ultrasound energy and ...

ELECTRICAL STIMULATOR FOR PERIPHERAL STIMULATION

Neurostimulation assemblies, systems, and methods make possible the providing of short-term therapy or diagnostic testing by providing electrical connections between muscles and/or nerves inside the body and stimulus generators and/or recording instruments mounted on the surface of the skin or carried outside the body. The assembly affords maximum patient mobility and comfort through differentiated components having minimal profiles and connected by way of detachable and adjustable connections. 132-. (canceled)33. A lead connector for a percutaneous electrical stimulator system including a stimulation electrode with a proximal lead and a stimulator unit with a patient cable , the lead connector comprising:a body having at least one slot or channel, said channel sized to receive the lead;a contact element proximate to at least portion of the slot or channel to establish electrical contact with the lead; andwherein the contact element also establishes an electrical connection with the patient cable.34. The lead connector of wherein the contact element includes micro-structured barbs to engage the lead.35. The lead connector of including a breakaway mechanism to allow for selective disconnection of the body from the patient cable.36. The lead connector of wherein the breakaway mechanism includes a Velcro-style claim 35 , hook and loop attachment.37. The lead connector of wherein the breakaway mechanism includes a neodymium magnet.38. The lead connector of wherein the breakaway mechanism includes at least one of: a rare earth magnet claim 35 , a samarium cobalt magnet claim 35 , an alnico magnet claim 35 , a ceramic magnet claim 35 , and a ferrite magnet.39. The lead connector of further comprising an insulation displacement device proximate to the slot or channel claim 33 , said device engaging the lead to remove any electrical insulation therefrom as or after the lead is inserted into the slot or channel.40. The lead connector of wherein the contact element includes ...

Systems and Methods for Increasing A Delay in the Gastric Emptying Time for a Patient Using a Transcutaneous Electro-Dermal Patch

The disclosed wearable device modulates a patient's gastric emptying time and/or gastric retention time. The wearable device includes a microprocessor, electrical stimulator and at least one electrode configured to deliver electrical stimulation to the epidermis, through a range of 0.1 mm to 10 mm or a range of 0.1 mm to 20 mm of the dermis, of a T2 dermatome to a T12 dermatome or meridian of the patient, a C5 to a T1 dermatome across the hand and/or arm, and/or the upper chest regions. The device is adapted to provide electrical stimulation as per stimulation protocols and to communicate wirelessly with a companion control device configured to monitor and record appetite patterns of the patient. The control device is also configured to monitor, record, and modify stimulation parameters of the stimulation protocols. 1. An electrical dermal patch configured to cause a delay in emptying of a patient's stomach contents , comprising:a housing having a base surface, wherein said base surface is defined by a total base surface area;a controller positioned within the housing;at least one electrode having a base surface and attached to the base surface of said housing, wherein the base surface of the at least one electrode is adapted to be in electrical contact with said patient's epidermis and wherein at least one of the base surface of the at least one electrode and the base surface of the housing is adapted to be adhered to an epidermis of the patient; anda pulse generator positioned within the housing and in electrical communication with the controller and said at least one electrode, wherein the pulse generator is configured to generate a plurality of stimulation sessions, wherein each of said plurality of stimulation sessions comprises a plurality of electrical pulses and wherein each of said plurality of electrical pulses is defined by a plurality of stimulation parameters, said plurality of stimulation parameters being defined such that, after applying at least one ...

Methods for Renal Neuromodulation

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for extravascular delivery of pulsed electric fields to achieve such neuromodulation. 165-. (canceled)66. A method for reducing blood pressure in a human patient , the method comprising:implanting a neural stimulation system in the patient below the patient's skin, wherein the neural stimulation system includes an electric field generator electrically coupled to a ring-shaped electrode positioned adjacent to target nerves of the sympathetic nervous system; anddelivering generated electrical signals from the electric field generator to the target nerves via the ring-shaped electrode, thereby altering the naturally occurring neural signals propagating through the nerves,wherein delivering the generated electrical signals to the target nerves of the patient results in a therapeutically beneficial reduction in blood pressure of the patient.67. The method of wherein delivering generated electrical signals from the electric field generator to the target nerves via the ring-shaped electrode comprises delivering generated stimulation signals to the target nerves.68. The method of wherein delivering generated electrical signals from the electric field generator to the target nerves via the ring-shaped electrode comprises delivering at least two different levels of generated stimulation signals to the target nerves.69. The method of wherein delivering generated electrical signals from the electric field generator to the target nerves via the ring-shaped electrode comprises delivering ...

Personalized network searching

Personalized network searching, in which a search query is received from a user, and a request is received to personalize a search result. Responsive to the search query and the request to personalize the search result, a personalized search result is generated by searching a personalized search object. Responsive to the search query, a general search result is generated by searching the general search object. The personalized search result and the general search result are provided to a client device, an advertisement is selected based at least in part upon the personalized search object, and the advertisement, the personalized search result, and the general search result are displayed.

Methods and apparatus for supporting microneedles

Methods and apparatus for supporting microneedles are provided. The apparatus includes a plurality of pedestals extending away from a base and transversely spaced-apart from each other by inter-pedestal volumes. Each of the pedestals has a transversely extending contact surface. For each of the pedestals, one or more microneedles extend from the contact surface of the pedestal.

Electromyographic Lead Positioning and Stimulation Titration in a Nerve Stimulation System for Treatment of Overactive Bladder

The present invention provides improved methods for positioning of an implantable lead in a patient with an integrated EMG and stimulation clinician programmer. The integrated clinician programmer is coupled to the implantable lead, wherein the implantable lead comprises at least four electrodes, and to at least one EMG sensing electrode minimally invasively positioned on a skin surface or within the patient. The method comprises delivering a test stimulation at a stimulation amplitude level from the integrated clinician programmer to a nerve tissue of the patient with a principal electrode of the implantable lead. Test stimulations are delivered at a same stimulation amplitude level for a same period of time sequentially to each of the four electrodes of the implantable lead. A stimulation-induced EMG motor response is recorded with the integrated clinician programmer for each test stimulation on each electrode of the implantable lead via the at least one pair of EMG sensing electrodes so as to facilitate initial positioning of the implantable lead at a target stimulation region. 1. (canceled)2. A method for improved positioning of an implantable neurostimulation lead in a patient with a clinician programmer coupled to the implantable neurostimulation lead comprising a plurality of neurostimulation electrodes , wherein at least one EMG sensing electrode is minimally invasively positioned on a skin surface or within the patient , the method comprising:delivering a first test stimulation at a stimulation amplitude level from the clinician programmer to a nerve tissue of the patient with a principal neurostimulation electrode of the implantable neurostimulation lead, wherein the principal neurostimulation electrode is selected from the plurality of neurostimulation electrodes of the implantable neurostimulation lead;delivering one or more second test stimulations at the same stimulation amplitude level as the first test stimulation sequentially to each remaining ...

SYSTEMS AND METHODS FOR ELECTROSTIMULATION THERAPY

A system for electrostimulation therapy includes two or more electrodes of different metals or metal alloys. The electrodes can be optionally provided on a flexible non-conducting substrate with a binder, thereby acting as a bandage or patch. Alternatively, the electrodes can be in the form of a needle, such as acupuncture needle, bracelets, armbands, wristbands, necklaces, or jewelry pieces. A method for electrostimulation therapy includes the steps of attaching a first electrode to a user or soil of a plant at a first location and attaching at least one additional electrode to the user or the plant at other locations for a predetermined period. The electrodes are not connected to a voltage or current source. Because at least two electrodes are of different metals, they cause an electrical current to flow via at least a portion of the user or the soil of the plant. 1. A method for electrical stimulation therapy , the method comprising:attaching a first electrode to a user at a first location, wherein the first electrode is substantially of a first metal or a first metal alloy, and wherein the first electrode is not connected to any electrical device; andattaching a second electrode to the user at a second location, wherein the second electrode is substantially of a second metal or a second metal alloy, wherein the second electrode is not connected to any electrical device, wherein the first metal or the first metal alloy differs from the second metal or the second metal alloy, wherein the first location differs from the second location, and wherein the first electrode and the second electrode cause an electrical current to flow via at least a portion of the user.2. The method of claim 1 , further comprising:providing a first wearable element including the first electrode;providing a second wearable element including the second electrode;mounting the first wearable element to the user at the first location; andmounting the second wearable element to the user at the ...

SYSTEMS AND METHODS FOR ASSESSMENT OF PAIN AND OTHER PARAMETERS DURING TRIAL NEUROSTIMULATION

Techniques are provided for use with a trial neurostimulation device having a lead for implant within a patient. In one example, neurostimulation is delivered using the lead while an indication of patient pain is detected. Various functions of the trial device are then controlled in response to patient pain, such as by adjusting neurostimulation control parameters to improve pain reduction, recording diagnostic information representative of patient pain or transmitting such parameters to a separate external instrument for analysis. In this manner, patient pain is automatically detected to provide objective feedback as to the efficacy of trial neurostimulation. Various embodiments of flexible trial neurostimulation device patches are described herein, including patches that are adhesively mounted over the point of entry of the trial lead into the patient, thus providing a comfortable patch that hygienically isolates the point of entry of the lead. 1. A neurostimulation patch device for use with an implantable neurostimulation lead for implant within a patient , the patch device comprising:a body member having a bottom portion adapted to be detachably affixed to patient skin;a neurostimulation circuit within the body member and configured to output neurostimulation signals:a connector located within the body member and configured to electrically couple the neurostimulation circuit to the implantable lead, wherein the bottom portion of the body member defines an opening for passage of an end of the implantable lead for connection to the connector; andat least one sensor operative to sense physiological signals mounted within the body member.2. The neurostimulation patch device of further comprising a pain detection system operative to detect an indication of patient pain based on signals received from the at least one sensor.3. The neurostimulation patch device of wherein the at least one sensor comprises a galvanic skin response (GSR) sensor and wherein the pain ...

Needle tip to apply current, handpiece, and apparatus for treating skin

A needle tip for applying current is provided. The needle tip for applying current includes a needle fixing unit, and a plurality of needles disposed on one surface of the needle fixing unit, wherein each needle includes at least one active region which is formed, as an insulator is not coated on a partial area of the needle except for a distal end portion of the needle and electromagnetically conducted. The plurality of needles are connected to electrodes having alternately different polarities. When the plurality of needles include the plurality of active regions spaced apart from each other, the intensity of current applied to each of electrodes connected to the plurality of needles is adjusted, such that electric energy is transmitted between the plurality of active regions spaced apart from each other.

HIGH VOLTAGE CONNECTORS AND ELECTRODES FOR PULSE GENERATORS

A handheld, therapeutic electrode and connector that are compatible with high voltages from a pulse generator are disclosed. The electrode includes therapeutic terminals on a tip configured to deliver high voltage pulses safely to a patient. The electrode includes sleeves, bosses, wiring channels, and other features that maximize a minimum clearance distance (across non-conductive surfaces) and air clearance between conductive connectors themselves or the connectors and a user, thus preventing dangerous arcing. Internal surfaces and seams are taken into account. The connector and its mating outlet can include similar features to maximize clearance distance. Skirts, skirt holes, and finger stops are also employed, and they can be on either the connector or outlet, or the tip or handle of the electrode.

SYSTEM FOR ELECTRICAL STIMULATION OF NERVES

In a system for electrical stimulation of nerves of a living being a pulse generator is configured to provide a sequence of electrical and/or vibration pulses to at least one electrode and/or vibration generator that are maintained in close proximity to the nerve of interest with the use of means for securing the electrode to the skin or tissue of the living being.

Vagal nerve stimulation to reduce inflammation associated with an aneurysm

Devices, systems and methods are disclosed for reducing inflammation associated with an aneurysm in a patient. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in the vagus nerve. Vagus nerve stimulation is used to modulate the release of neurotransmitters in the brain and to reduce inflammation that may lead to the formation, growth, rupture or hemorrhage of an aneurysm.

Method and apparatus to perform structural and mechanical change to joint capsule, tendon, and ligament

A method of treating connective tissue by applying a DC current to the tissue in the absence of intentionally heating the tissue.

System and method for collecting biological data

A system for obtaining biological data from a subject animal, the system comprising at least one neural transducer embedded internally within the subject animal and arranged for interaction with nerves of the subject animal, at least one sensor arranged for sensing data of a parameter of the subject animal, and an external module mounted externally on the subject animal and connected by a wired connection to at least one of the at least one neural transducer or the at least one sensor. The wired connection comprises a sealed and ported through skin interface device.

Method of screening a patient for determining a therapy regimen

A method for screening a patient suffering from a urinary dysfunction for determining whether a patient is a viable candidate for therapy through the use of a neurostimulator. The neurostimulator is placed on the patient's skin and is operationally activated to transmit electrical or magnetic signals to a target nerve during therapy sessions held over an assessment time interval. During the therapy sessions, the patient provides therapeutic responses to the electrical or magnetic signals during the therapy sessions. Based upon the patient's therapeutic responses a determination is made to either implant the neurostimulator in the patient's body or to perform an alternative procedure.

Methods and Apparatus for Monopolar Renal Neuromodulation

Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, monopolar neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such monopolar neuromodulation is performed bilaterally.

NEEDLE SYSTEM

A needle system for penetrating to or passing thought an object or an organ comprising a semiconductor die, one or more needles, wherein the needles move relative to the die using one or more actuators. The actuators are controlled by a controller wherein the controller instruct the needle to penetrate into or to pass through and/or retract from the object or organ. The needle system is used among other treatments for drug delivery, blood extraction, blood analysis, glucose measurements, blood measurements, nerve system stimulus treatment, hair removal, skin lesions coloring or removal or tattoo painting or removal. 1. An apparatus for piercing an object comprising:(a) a semiconductor die;(b) one or more needles; and(c) one or more actuators,wherein the actuators and the needles are fabricated on the die, the actuators are attached both to the die substrate and to the needles, the actuators move the needles relative to the die plane, and the needles are configured to pierce the object.2. The apparatus of claim 1 , wherein said one or more needles are configured to slide over the die plane.3. The apparatus of claim 1 , wherein one or more said needles moves out of die plane.4. The apparatus of claim 1 , wherein said one or more actuators are thermal actuators.5. The apparatus of claim 1 , wherein said one or more actuators are piezoelectric actuators.6. The apparatus of claim 1 , wherein said one or more needles are used as ultrasound transducers to generate an image of the object.7. The apparatus of claim 1 , wherein said needle has mechanical support to hold the needle and to allow sliding only to a desired direction.8. A needle system comprising a controller and one or more apparatuses of .9. The needle system of claim 8 , wherein said object is a human organ and the needle system is used for hypodermal treatment.10. The needle system of claim 9 , wherein said needle system is further used for any one of or any combination of (1) drug delivery; (2) blood ...

SYSTEMS AND METHODS THAT PROVIDE ELECTRICAL STIMULATION TO A NERVE TO REDUCE A REFLEX THAT AFFECTS A BODILY FUNCTION

One aspect of the present disclosure relates to a system for electrical stimulation. A waveform generator can be configured to generate an electrical waveform. An electrode can be electrically coupled to the waveform generator and configured to deliver the electrical waveform to a nerve to reduce at least one reflex that affects a bodily function. 111-. (canceled)12. A method for affecting a bodily function in a subject , the method comprising the steps of:generating, by a waveform generator, an electrical waveform; anddelivering, by an electrode coupled to the waveform generator, the electrical waveform to a nerve comprising an afferent nerve fiber of the subject to stimulate the afferent nerve fiber to affect the bodily function.13. The method of claim 12 , wherein the electrode is a surface electrode or a subcutaneous electrode.14. The method of claim 12 , wherein the electrical waveform comprises a burst waveform.15. The method of claim 12 , wherein the electrical waveform stimulates the afferent nerve to reduce urethral reflexes that impede urine flow16. The method of claim 15 , wherein the bodily function comprises voiding the urinary bladder.17. The method of claim 16 , further comprising stimulating claim 16 , by a bladder driver claim 16 , a second nerve to activate the urinary bladder to facilitate the voiding when the urethral reflexes are reduced.1820-. (canceled) This application claims the benefit of U.S. Provisional Application No. 61/827,024, filed May 24, 2013, entitled “Surface Electrical Stimulation for Sensory Feedback to Improve Bladder Voiding in Neurological Disorders,” the entirety of which is hereby incorporated by reference for all purposes.This work was supported, at least in part, by grant number DK077089 and grant number EB004314 from the Department of Health and Human Services, National Institutes of Health. This work was also supported, at least in part, by grant number RR&D668 from the Department of Veterans Affairs. The United States ...

Methods for stimulating a dorsal root ganglion

Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.

METHODS AND APPARATUSES FOR REDUCING BLEEDING VIA COORDINATED TRIGEMINAL AND VAGAL NERVE STIMULATION

Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive. 1. A method of reducing bleed time in a subject by combined vagus nerve and trigeminal nerve stimulation , the method comprising:applying one or more of mechanical or electrical activation to the subject's trigeminal nerve and vagus nerve; andreducing bleed time of the bleeding by at least 20%.2. The method of claim 1 , wherein applying comprises non-invasively applying one or more of mechanical or electrical activation.3. The method of any of claim 1 , wherein the subject is human.4. The method of any of claim 1 , wherein applying comprises applying one or more of mechanical or electrical activation to one or more of an ophthalmic claim 1 , maxillary and/or mandibular branch of the subject's trigeminal nerve and applying stimulation to the auricular vagus nerve.5. The method of any of claim 1 , wherein reducing bleeding time comprises reducing bleeding time of one or more of an internal hemorrhage or an external hemorrhage.6. The method of any of claim 1 , wherein applying comprises applying electrical stimulation.7. The method of any of claim 1 , wherein applying comprises applying electrical stimulation to both the vagus nerve and the trigeminal nerve at between 1-50 Hz and between 0.5-15V having a pulse width of between 0.5 ms and 10 ms.8. The method of any of claim 1 , wherein applying comprises applying for between 1 minute and 45 minutes.9. A method of reducing or limiting blood loss in a hemorrhaging subject the method comprising:applying one or more of mechanical or electrical activation to the subject's trigeminal nerve;concurrently applying one or ...

NEURAL PROSTHESIS SYSTEM AND METHOD OF CONTROL

Multiple designs, systems, methods and processes for control using electrical signals recorded from clinically paralyzed muscles and nerves are presented. The discomplete neural prosthesis system and method for clinically paralyzed humans utilizes a controller. The controller is adapted to receive a volitional electrical signal generated by the human that is manifest below the lesion that causes the clinical paralysis. The controller uses at least the volitional electrical signal to generate a control signal that is output back to a plant to change the state of the plant, which in one aspect is one or more of the user's paralyzed muscles to achieve a functional result or to devices in the environment around the user that are adapted to receive commands from the controller. 121-. (canceled)22. A neural prosthesis system , comprising:an electrode configured to detect a volitional electrical potential generated within a human body below a lesion in the nervous system, wherein the volitional electrical potential indicates a user's desired action;a controller coupled to the electrode and configured to generate a control signal based on the detected volitional electrical potential; andan assistive device to receive the control signal and respond in a functional manner to perform the user's desired action based on the control signal.23. The neural prosthesis system of claim 22 , wherein the control signal is configured to cause the assistive device to make a functional movement.24. The neural prosthesis system of claim 22 , wherein the controller is further configured to generate the control signal based on a state of a single axis hinged joint of the human body and the detected volitional electrical potential claim 22 ,wherein the state of the human body comprises a set of variables that define a specific combination of characteristics of the single axis hinged joint.25. The neural prosthesis system of claim 22 , wherein the controller is configured to generate the ...

METHOD, SYSTEM, AND APPARATUS FOR DERMATOLOGICAL TREATMENT

Embodiments of dermatological cell treatment are described generally herein. Other embodiments may be described and claimed. 1. (canceled)2. (canceled)3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. (canceled)8. (canceled)9. (canceled)10. (canceled)11. (canceled)12. (canceled)13. (canceled)14. (canceled)15. (canceled)16. (canceled)17. (canceled)18. (canceled)19. (canceled)20. (canceled)21. A method of treating dermatological tissue , comprising:placing a user holdable device releasably couplable deployable needle assembly end surface on or near dermatological tissue to be treated, the holdable device including a proximal end and the releasably couplable deployable needle assembly, the releasably couplable deployable needle assembly mechanically separatably from the proximal end and including a plurality of needles extendable from the releasably couplable deployable needle assembly end surface, one of the proximal end and the releasably couplable deployable needle assembly including at least one electrical contact and the other including at least one electrical contact couplable to the one of the proximal end and the releasably couplable deployable needle assembly at least one electrical contact; andcommunicating electrical signals from the proximal end to releasably couplable deployable needle assembly via the electrical conductors.22. The method of claim 21 , further comprising energizing a motor coupled to a releasably couplable deployable needle assembly to cause a plurality of the extendable needles to extend a desired distance from the releasably couplable deployable needle assembly end surface.23. The method of claim 22 , further comprising energizing the plurality of extended needles via a signal generator electrically coupled to the proximal end.24. The method of claim 21 , wherein one of the least one electrical contacts includes a pin that is extendable in the same direction as the needles to maintain an electrical connection with the other of the ...

APPARATUS AND METHOD FOR POSITIONING, IMPLANTING AND USING A STIMULATION LEAD

An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath. 1. An introducer system for positioning , testing , and deploying a lead for percutaneous peripheral nerve stimulation , the system comprising:an electrical stimulus generator unit;a needle assembly including an outer sheath having an outer circumference and defining a lumen, an inner sheath carried completely within the lumen during positioning and testing of the system, and a plurality of test electrodes positioned along the outer circumference and connected to the stimulus generator unit;a self-anchoring open-coiled helical stimulation lead carried within the inner sheath and having a conductive distal anchor, said anchor comprising an integrated electrode, and a proximal end in communication with the stimulus generator unit,a deployment mechanism cooperating relative to the lead and the needle assembly to deploy the lead out of the needle assembly at a selected position identified by the test electrode during positioning and testing of the system; andwherein the self-anchoring lead remains confined within the needle assembly prior to deploying the system and the distal anchor remains deployed in tissue after deploying the system.2. The system of claim 1 , wherein the deployment mechanism is selected from a plunger and a spacer.3. The system of claim 1 , wherein two or more test electrodes are provided as an array spaced axially along ...

Immune system neuromodulation and associated systems and methods

Methods for treating a patient using therapeutic immune system neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including modulating nerves proximate a vessel or duct of an immune system organ using an intravascularly or intraluminally positioned therapeutic element. One or more measurable physiological parameters corresponding to an immune system disorder, a condition associated with sympathetic activity in an immune system organ, or a condition associated with central sympathetic activity in the patient can thereby be reduced.

Catheter device including flow sensing

Devices and methods are provided for performing an ablation procedure on tissue with flow monitoring using flow sensors. The devices include a catheter, and at least one flow sensor disposed on the catheter, and a component for applying the ablation procedure. An assessment module provides an indication of the efficacy of the ablation procedure based on the flow measurement from the flow sensor.

DEVICES FOR THERAPEUTIC NASAL NEUROMODULATION AND ASSOCIATED METHODS AND SYSTEMS

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis. 1103.-. (canceled)104. A method for treating a condition within a nasal cavity of a patient , the method comprising:advancing a cryotherapeutic applicator of a treatment device to a target site within a nasal cavity of a patient, wherein the target site is associated with one or more posterior nasal nerves; anddelivering, via the cryotherapeutic applicator, cryotherapeutic cooling to the target site at a level sufficient to therapeutically modulate one or more posterior nasal nerves innervating nasal mucosa, wherein the cooling is provided in targeted manner and avoids collateral damage to a lacrimal nerve to thereby avoid causing dry eye while treating the condition within the nasal cavity.105. The method of claim 104 , wherein delivery of the cryotherapeutic cooling to the target site interrupts at least one neural pathway innervating nasal mucosa.106. The method of claim 105 , wherein delivery of the cryotherapeutic cooling to the target site causes multiple points of interruption of neural branches associated with the one or more posterior nasal nerves to thereby decrease ...

Methods and Apparatus for Stimulation of Biological Tissue

In illustrative implementations of this invention, interferential stimulation is precisely directed to arbitrary regions in a brain. The target region is not limited to the area immediately beneath the electrodes, but may be any superficial, mid-depth or deep brain structure. Targeting is achieved by positioning the region of maximum envelope amplitude so that it is located at the targeted tissue. Leakage between current channels is greatly reduced by making at least one of the current channels anti-phasic: that is, the electrode pair of at least one of the current channels has a phase difference between the two electrodes that is substantially equal to 180 degrees. Pairs of stimulating electrodes are positioned side-by-side, rather than in a conventional crisscross pattern, and thus produce only one region of maximum envelope amplitude. Typically, current sources are used to drive the interferential currents. 1. A method comprising:(a) creating a first electric field between a first pair of electrodes and creating a second electric field between a second pair of electrodes, in such a way that the first and second electric fields constructively and destructively interfere with each other to create an amplitude-modulated waveform, which waveform has an envelope amplitude; and(b) controlling location of a spatial position at which the envelope amplitude of the waveform is greatest, in such a way that the spatial position is located in biological tissue.2. The method of claim 1 , wherein the first and second pairs of electrodes are positioned in such a way that:(a) the first pair of electrodes is positioned entirely on one side of a geometric plane;(b) the second pair of electrodes is positioned entirely on another side of the geometric plane; and(c) the geometric plane intersects the biological tissue.3. The method of claim 1 , wherein distance between electrodes in the first pair of electrodes is different than distance between electrodes in the second pair of ...

ELECTRO-ACUPUNCTURE (EA) SYSTEM HAVING A WEARABLE ELECTRO-ACUPUNCTURE NEUROSTIMULATOR FOR ENHANCED CLINICAL AND SCIENTIFIC OUTCOMES, AND A METHOD

An electro-acupuncture (EA) system and method for performing EA on a patient are provided. The EA system comprises a wearable neurostimulator device, at least a first pair of electrically-conductive acupuncture needles and a system controller. The wearable neurostimulator device comprises a casing, an EA circuit mechanically coupled to the casing, and an attachment device mechanically coupled to the casing and adapted to removably secure the wearable neurostimulator device to the patient. The first pair of electrically-conductive acupuncture needles is mechanically coupled to the casing and electrically coupled to the EA circuit. The system controller is in communication with the EA circuit of the wearable neurostimulator device via a communication link and controls the EA circuit to cause the EA circuit to output an output voltage selected by the system controller at a frequency selected by the system controller. 1. An electro-acupuncture (EA) system for performing EA on a patient , the EA system comprising:a wearable neurostimulator device comprising a casing, an EA circuit mechanically coupled to the casing, and an attachment device mechanically coupled to the casing and adapted to removably secure the wearable neurostimulator device to the patient;at least a first pair of electrically-conductive acupuncture needles electrically coupled to a first pair of output terminals of the EA circuit; anda system controller in communication with the EA circuit of the wearable neurostimulator device via a communication link, the system controller controlling the EA circuit by sending at least a first set of setting information to the EA circuit over the communication link to cause the EA circuit to output at least a first output voltage at a first frequency from the first pair of output terminals in accordance with the first set of setting information selected by the system controller.2. The EA system of claim 1 , wherein the system controller comprises a smartphone and ...

DEVICE AND METHOD FOR FRACTIONAL RF TREATMENT OF THE SKIN

A system and method for treating the skin by heating at least one discrete skin volume, comprising at least one treatment tip reversibly connectable to at least one applicator. The treatment tip comprises one or more electrodes, with the electrodes having one or more spaced apart protruding conducting elements. The protruding conducting elements are characterized by dimensions of height A and hypotenuse B, where the ratio A/B is in a predetermined range, and the protruding conducting elements penetrate the skin surface at discrete locations. The electrodes are configured to apply energy to skin volumes around the discrete locations so as to heat the skin volumes. The applicator comprises an energy generator configured to apply energy to the skin volumes by means of the electrodes and the spaced apart protruding conducting elements. 1. A system for treating the skin by heating at least one discrete skin volume , comprising:a. at least one treatment tip comprising N electrodes, N being an integer greater than or equal to 1; at least one said electrode having at least one spaced apart protruding conducting element; at least one said protruding conducting element is characterized by dimensions of height A and hypotenuse B, at least one said protruding conducting element is configured to penetrate the skin surface at at least one discrete location; at least one said electrode is configured to apply energy to said at least one discrete skin volume so as to heat said at least one discrete skin volume; and,b. an applicator comprising at least one energy generator configured to apply said energy to said at least one skin volume by means of said at least one electrode and said at least one spaced apart protruding conducting element; and,c. at least one delivery indicator;wherein the ratio A/B is in a predetermined range; further wherein said at least one delivery indicator is configured to indicate that said energy is currently being delivered via said applicator.2. The ...

SYSTEM FOR IMPROVING NEUROSTIMULATION TREATMENT COMPLIANCE WITH GAMIFICATION

Gamification for a pelvic disorder regimen has a processor for operating a control module configured to define a programmable treatment regimen. A neurostimulator is connected to the processor and the control module. The neurostimulator applies electrical or magnetic signals to the user according to the programmable treatment regimen which includes at least one treatment task to be performed by the user. A gramification module calculates and stores a set of scores of the user in performing at least one task defined in the programmable treatment program associated with one or more events defined in the programmable treatment program to provide a score assigned to each task performance. A user interface is connected to the control module and provides the user with information associated with the scores attained by the user. 1. A system for gamification of a pelvic disorder treatment regimen that includes the provision of neurostimulation comprising:at least a first processor configured for operating a control module, said control module configured to define a programmable treatment regimen for treatment of a user having a pelvic disorder;at least one neurostimulator coupled to said control module and said processor, said neurostimulator adapted to provide electrical or magnetic stimulation signals to said user in accordance with said programmable treatment regimen having at least one set of scheduled events requiring said user to perform at least one treatment task associated with a respective event of said at least one set of scheduled events, said neurostimulator further configured to communicate data or control signals to and from the at least one first processor;a gamification module configured for calculating and storing at least one score of said user in performance of said at least one treatment task associated with said respective event; and,at least one user interface module coupled to the control module, said user interface module being configured to provide ...

SYSTEMS AND METHODS FOR PROVIDING PERCUTANEOUS ELECTRICAL STIMULATION

Systems and methods according to the present invention relate to a novel peripheral nerve stimulation system for the treatment of pain, such as pain that exists after amputation. 1. A system comprising:a patch member having an adhesive disposed on a first side and a patch mounting structure disposed on a second side, opposite the first side, and an electrically conductive return electrode material disposed between the first side and the second side; a housing having oppositely disposed, substantially planar top and bottom surfaces, wherein the top surface is imperforate;', 'a device mounting structure on the bottom surface physically mated with the patch mounting structure;', 'electrical stimulation generation circuitry disposed at least partially within the housing;', 'one or more of a rechargeable battery, an inductive charging circuit adapted to receive an inductive charging signal, and a wireless communication module adapted to receive wireless communications to select or a stimulation pattern to be generated by the electrical stimulation circuitry;', 'an electrode electrically coupled to the electrical stimulation generation circuitry., 'an electrical stimulation device comprising2. A system according to claim 1 , wherein the top surface and the bottom surface of the housing are separated by a device thickness claim 1 , wherein the housing further comprises a perimeter edge extending from the bottom surface and a sloped interface edge connecting the top surface to the perimeter edge along a majority of the perimeter thereof wherein the height of the perimeter edge claim 1 , measured perpendicular to the top and bottom surfaces claim 1 , is less than the device thickness.3. A method of treating bodily pain of an animal comprising the steps of:providing a patch member having an adhesive disposed on a first side and a patch mounting structure disposed on a second side, opposite the first side, and an electrically conductive return electrode material disposed ...

SYSTEMS, METHODS AND DEVICES FOR A SKULL/BRAIN INTERFACE

Methods, devices, and systems induce neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Methods, devices, and systems identify where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces include diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain. 1. A system for facilitating the delivery of a form of neuromodulation to , or the detecting of signals from , one or more target regions of a subject's brain , the system comprising:a transcranial channel configured for transcranial implant and having a transcranial inner lumen adapted to conduct an ionic current to or from a first target region interior of the cranium; anda transparenchymal channel configured for brain implant and to be associated with the transcranial channel, the transparenchymal channel having a transparenchymal inner lumen adapted to conduct the ionic current to or from a second target region interior of the brain.2. The system of claim 1 , wherein the transcranial channel comprises:a transcranial channel proximal end designed to be oriented towards an outer layer of the skull;a transcranial channel distal end designed to be oriented towards the first target region; andan inner wall extending between the transcranial channel proximal end and the transcranial channel distal end and defining the transcranial inner lumen.3. The system of claim 2 , wherein the inner wall is formed of an ion permeable material.4. The system of wherein the transcranial channel further comprises an outer wall formed of a material that is not ion permeable.5. The system of claim 2 , wherein the transcranial ...