31-05-2018 дата публикации
Номер: US20180148476A1
Принадлежит:
The present invention provides peptides and compositions that are useful for the treatment of gastrointestinal disorders or for colon cleansing. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms. 1. A peptide or a pharmaceutically acceptable salt thereof , wherein the peptide comprises the amino acid sequence{'sub': 1', '2', '3', '4', '5', '6', '7', '8', '9', '10', '11', '12', '13', '14', '15', '16', '17', '18', '19', '20', '21, 'XaaXaaXaaXaaXaaXaaXaaXaaXaaXaaXaaXaaXaaXaaAlaXaaXaaGlyXaaXaaXaa(SEQ ID NO: 1), or a pharmaceutically acceptable salt thereof; wherein'}{'sub': '1', 'Xaais BE or is absent;'}{'sub': '2', 'Xaais BK, Asn or is absent;'}{'sub': '3', 'Xaais Asn, Ser or is absent;'}{'sub': '4', 'Xaais Ser or is absent;'}{'sub': '5', 'Xaais Ser, Asn, Ile, BE or is absent;'}{'sub': '6', 'Xaais Tyr, Asp, 4-fluorophenylalanine ((4-F)Phe), BK or is absent;'}{'sub': '7', 'Xaais Cys, cystathionine (Cth), allylglycine (Ag), Hag, or Asp;'}{'sub': '8', 'Xaais Cys, cystathionine (Cth), penicillamine (Pen), or allylglycine (Ag);'}{'sub': '9', 'Xaais Glu, Asp, Ser, Thr, or Gln;'}{'sub': '10', 'Xaais Leu, cyclohexylalanine (Cha), Phe, or 4-fluorophenylalanine ((4-F)Phe);'}{'sub': '11', 'Xaais Cys, Ag, or penicillamine (Pen);'}{'sub': '12', 'Xaais Cys, allylglycine (Ag), Hag, Cth, Dpr, or Val;'}{'sub': '13', 'Xaais Asn or Leu;'}{'sub': '14', 'Xaais Pro, Val, sarcosine (Sar), Leu, or Hydroxyproline (OH-Pro);'}{'sub': '16', 'Xaais Cys, Ag, Pen or Cth;'}{'sub': '17', 'Xaais Tyr, Thr, cyclohexylalanine (Cha), 4-fluorophenylalanine ((4-F)Phe), Phe, Ser, or Ala;'}{'sub': '19', 'Xaais Cys, Ag or Pen;'}{'sub': '20', 'Xaais Tyr, Leu, 4-fluorophenylalanine ((4-F)Phe), cyclohexylalanine (Cha), D-Tyr,'}N-Methyl Tyr (Nme-Tyr) or is absent;{'sub': '21', 'Xaais absent or Asn;'}wherein at least one Xaa is ...
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