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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 29702. Отображено 100.
26-01-2012 дата публикации

Oral compositions for treating tooth sensitivity and methods of use and manufacture thereof

Номер: US20120020899A1
Автор: Lynette Zaidel, Michael Precipe, Suman K. Chopra
Принадлежит: Colgate Palmolive Co

The invention encompasses oral care compositions comprising one or more active component and one or more adhesive polymers, which cause the active component to adhere to the tooth surface. In certain embodiments the active agent is an occlusion agent. The invention also encompasses methods of treating the teeth or a teeth surface with an active agent. In certain embodiments, the invention encompasses treating the teeth with an occlusion agent to prevent or alleviate tooth sensitivity.

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Номер записи: 1
26-01-2012 дата публикации

Densensitizing dentifrice exhibiting dental tissue antibacterial agent uptake

Номер: US20120020900A1
Автор: Guofeng Xu, Ravi Subramanyam
Принадлежит: Colgate Palmolive Co

An oral composition exhibiting increased uptake by dental tissue of antibacterial compounds contained therein and eliminating or substantially reducing the discomfort and pain associated with dentinal hypersensitivity. The composition includes an orally acceptable vehicle for such composition, an effective therapeutic amount of an antibacterial compound, a mixture of anionic surfactant and amphoteric surfactant, the mixture having 0.1 wt. % to 2.0 wt. % anionic surfactant and 0.8 wt. % to 2.0 wt. % amphoteric surfactant, and a potassium ion releasable compound.

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Номер записи: 2
26-01-2012 дата публикации

Dual action dentifrice compositions to prevent hypersensitivity and promote remineralization

Номер: US20120021031A1
Автор: Lynette Zaidel, Michael Prencipe, Suman K. Chopra
Принадлежит: Colgate Palmolive Co

The invention encompasses combinations of bioactive glass composition and potassium salts that are useful in conjunction with delivery agent such as, for example, toothpastes, mouthwashes, and oral gels. In certain embodiments, the compositions of the invention form a rapid and continuous reaction with body fluids (e.g., saliva) to promote the immediate and long-tem release of Ca and P ions to produce a stable crystalline layer deposited onto and into the dentin tubules for the immediate and long term reduction of dentin hypersensitivity and tooth surface remineralization.

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Номер записи: 3
02-02-2012 дата публикации

Method and Composition for Reducing Exhaled Carbon Dioxide Emissions

Номер: US20120027827A1
Автор: Michael Lefenfeld, Tuhin Ganguly
Принадлежит: Individual

A method and composition for reducing the amount of carbon dioxide exhaled by a user by placing a composition comprising a delivery vehicle and a carbon dioxide sequestering agent into a user's mouth and allowing the carbon dioxide sequestering agent to react with the carbon dioxide present in the user's breath thereby reducing the amount of carbon dioxide exhaled by the user.

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Номер записи: 4
09-02-2012 дата публикации

Dentifrice composition and method of use

Номер: US20120034282A1
Автор: Evangelia Arvanitidou, Joe Vazquez, Mary Horchos, Qing Claire He, Thomas Boyd, Ying Yang
Принадлежит: Colgate Palmolive Co

An exfoliating dentifrice composition is described that contains a plurality of granules and an orally acceptable vehicle. The granules include at least one polymeric binding agent. The composition includes at least one abrasive agent having an average particle diameter of 0.01 mm to 4 mm. Also included are methods of exfoliating an oral cavity soft tissue by use of the composition.

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Номер записи: 5
22-03-2012 дата публикации

Prophylaxis Paste Holder Dispenser with Multiple Prophylaxis Pastes

Номер: US20120067748A1
Автор: Jeanette Gail Vargo, Michael Schmitz, Michael Turner, Peter Jung, Rachel Barton
Принадлежит: Individual

A dental prophylaxis paste holder dispenser comprises a first prophylaxis paste and a second prophylaxis paste. The first prophylaxis paste has a first material. The second prophylaxis paste has a second material. The first material has a first material property and the second material has a second material property. The first material property differs from the second material property.

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Номер записи: 6
22-03-2012 дата публикации

Color changing consumer products

Номер: US20120070478A1
Автор: Guisheng Pan, Harsh M. Trivedi, Nora Lin, Thomas Boyd, Wei Wang
Принадлежит: Colgate Palmolive Co

The invention relates to personal care products containing multilayer films with decorative layers and may impart a noticeable color change. The invention is applicable in products including type toothpaste, soaps, and other products until diluted with water (or saliva).

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Номер записи: 7
05-04-2012 дата публикации

Oral Care Compositions With Improved Flavor

Номер: US20120082628A1
Автор: Cathy Renee Schinaman, Christine Marie Cahen, John Christian Haught, Koti Tatachar Sreekishna, Wenzhu Zhao, Yakang Lin
Принадлежит: Procter and Gamble Co

Oral care compositions having improved taste, said compositions comprising: a carrier material; from about 0.001 to about 10%, by weight of the composition, of an oral care component selected from metal salts, antimicrobial agents, bad breath reduction agents, bleaching agents, surfactants, or a combination thereof; and from about 0.0001 to about 1%, by weight of the composition, of a TRPA1 agonist selected from vanillin esters; benzoate esters; hydroxybenzoate derivatives; methoxy benzoate derivatives; hydroxybutanedioate derivatives; benzamidobenzoate derivatives; methylpropanoate derivatives; phenyl acetate derivatives; hex-3-enoate derivatives; 2-(furan-2-ylmethylsulfanyl)-3-methylpyrazine; phenylmethoxymethylbenzene; (2R)-2-azaniumyl-3-[(2R)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3E)-2-hydroxy-4,8-dimethylnona-3,7-dienal; (2R)-2-azaniumyl-3-[(2S)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3Z)-3-butylidene-2-benzofuran-1-one; 3-methyl-N-(3-methylbutyl)butan-1-imine; 2-(furan-2-ylmethyldisulfanylmethyl)furan; and combinations thereof. Uses thereof and methods of improving the taste of an oral care composition.

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Номер записи: 8
05-04-2012 дата публикации

Oral Care Compositions With Improved Sweetness

Номер: US20120082630A1
Автор: Eva Schneiderman, John Christian Haught, Lowell Alan Sanker, Robert Leslie Swaine, Jr.
Принадлежит: Procter and Gamble Co

The present invention is directed to improved sweetener compositions and oral care compositions, especially those in the form of a toothpaste or oral/dental rinse, comprising the same. The sweetener composition comprises a combination of saccharin, sucralose and a rebaudioside, or sweeteners of similar sucrose equivalence and type, preferably in a ratio of about 1:about 1:about 2. The sweetener composition of the invention was found to significantly improve the taste profile, long lasting freshness and clean feel of oral care compositions and to deliver an in-use sweetness that was more natural and pleasant than artificial sweeteners alone.

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Номер записи: 9
19-04-2012 дата публикации

Oral care compositions comprising a polymeric dye

Номер: US20120093905A1
Автор: Andrew Joiner, Carole Jane Philpotts, Jinfang Wang, Qingsheng Tao, Sheng Meng, Stephen Norman Batchelor
Принадлежит: Conopco Inc

An oral care composition comprising a dye polymer, for modifying the colour of teeth.

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Номер записи: 10
19-04-2012 дата публикации

Organic Compounds Having Cooling Properties

Номер: US20120095042A1
Автор: Stefan Michael Furrer
Принадлежит: Givaudan SA

Provided are compounds of formula (I) wherein m is 0, 1 or 2; R I is a mono- or bicyclic heterocyclic ring system including one, two or three heteroatoms selected from nitrogen, sulphur and oxygen; R 2 is selected from hydrogen, methyl and ethyl; I) R 3 is hydrogen, methyl, or ethyl; and R 4 and R 5 are independently selected from ethyl and isopropyl; and R 3 , R 4 and R 5 together have at least 6 carbon atoms: or II) any two or all of R 3 , R 4 and R 5 form together with the carbon atom to which they are attached 3-para-menthyl, bornyl, or adamantyl; having cooling properties, their use as cooling agent and compositions including them.

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Номер записи: 11
03-05-2012 дата публикации

Abnormality detection system, abnormality detection method, and recording medium

Номер: US20120109582A1
Автор: Michiko Nakaya, Tsuyoshi Moriya, Yasutoshi Umehara, Yuki Kataoka
Принадлежит: Tokyo Electron Ltd

Disclosed is an abnormality detection system that accurately detects abnormalities that arise in a device. The abnormality detection system 100, which detects abnormalities that arise in a plasma processing device 2, is provided with: a plurality of ultrasonic sensors 41, which detects acoustic emissions (AE), which cause abnormalities to arise; a distributor 65, which distributes each output signal from the ultrasonic sensors 41 into a first signal and a second signal; a trigger 52, which samples the first signal at, for example, 10 kHz, and generates a trigger signal when predetermined characteristics are detected; a trigger generation time counter 54, which receives trigger signals and determines the time of trigger generation; a data logger board 55, which creates sampling data from sampling the second signal at, for example, 1 MHz; and a PC 50, which analyzes abnormalities arising in the plasma processing device 2 by means of performing a waveform analysis of data from the sampling data, said data corresponding to a set time period using the time of trigger generation determined by the trigger generation time counter 54 as a benchmark.

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Номер записи: 12
24-05-2012 дата публикации

Oral care composition

Номер: US20120128599A1
Автор: Andre Michelle Morgan, Davide Miksa, Evangelia S. Arvanitidou, Gregory Szewczyk, Laurence Du-Thumm, Lyndsay Schaeffer-Korbylo, Michael Prencipe
Принадлежит: Colgate Palmolive Co

Disclosed are oral care compositions and the use of such oral care compositions for treating conditions caused by biofilm formation. Also disclosed are methods for inhibiting biofilm formation and/or degrading biofilm. The oral care composition includes a sesquiterpenoid and an antimicrobial agent, in which the sesquiterpenoid and the antimicrobial agent are present in an amount effective to inhibit and/or degrade a biofilm in the oral cavity.

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Номер записи: 13
24-05-2012 дата публикации

Novel derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids and their uses as cooling compounds

Номер: US20120129827A1
Автор: Arkadiusz Kazimierski
Принадлежит: International Flavors and Fragrances Inc

The present invention relates to novel derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids represented by Formula I: wherein n is an integer of 1 or 2; R 1 , R 2 , R 3 , and R 4 are each independently selected from the group consisting of hydrogen and methyl; X is selected from the group consisting of oxygen and nitrogen; and R 5 is hydrogen or a C 1 -C 7 linear or branched acyclic hydrocarbon group, or R 5 together with X form a 3- to 8-membered heterocyclic hydrocarbon group, and their uses as cooling compounds.

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Номер записи: 14
24-05-2012 дата публикации

Tingling and salivating compositions

Номер: US20120129953A1
Автор: Anh Le, Catherine Maurel
Принадлежит: FIRMENICH SA

A sensate composition comprises a salivating component, a tingling component and a flavor, the salivating component being formed of at least a mixture of citric, malic and succinic acid, or of their salts, and the tingling component being formed of an ingredient selected from the group consisting of Jambu oleoresin, spilanthol, any extract containing either or both, and their mixtures. The sensate composition allows the preparation of consumer products having improved salivating properties.

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Номер записи: 15
31-05-2012 дата публикации

Application and Uses of PRG4 and Therapeutic Modulation Thereof

Номер: US20120134925A1
Автор: Benjamin Sullivan, David Sullivan, Edward R. Truitt, Nicole Barbara Justis Truitt, Tannin Schmidt
Принадлежит: Lubris Llc, Schepens Eye Research Institute Inc

The present invention relates to the uses of the protein PRG4 and therapeutic modulation thereof. In particular, the present invention relates compositions and methods utilizing PRG4 and therapeutic modulation thereof, including, use as a surgical lubricant, use in a treatment for prevention or reduction of post-surgical adhesions, use in a treatment for oral ulcerations, use as an athletic lubricating patch, use as a dermal filler, use in a treatment for dry mouth, use in a drug delivery method or composition, and use in nursing lubrication.

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Номер записи: 16
28-06-2012 дата публикации

Method of using apparatus for preventing plaque, preventing cativies and keeping teeth clean

Номер: US20120164082A1
Автор: Grace Yum Zimmermann, Kent Zimmermann
Принадлежит: Individual

A method for using an apparatus to gently clean an adult's or a child's teeth, gums, mouth, cheek surfaces and tongue with a liquid-filled cotton swab containing a proprietary solution that uses a natural sugar, in this case xylitol, that may prevent plaque from sticking to the user's teeth. Application of the xylitol solution may also kill bacteria and help prevent cavities from forming. The swab may be particularly useful for people that may have difficulty in brushing or flossing, such as victims of stroke or paralysis, people who cannot fully open their mouths, wearers of orthodontia, children, and babies.

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Номер записи: 17
12-07-2012 дата публикации

Toothpaste tablet

Номер: US20120175273A1
Автор: Allison J. LeGendre, David Wood, Scott Jacobs
Принадлежит: Archtek Inc

A toothpaste tablet having a tablet binder in an amount sufficient to form a tablet, a surfactant in amount sufficient to reduce surface tension and increase the rate of dissolution of the tablet in contact with saliva, a cranberry extract in an amount sufficient to reduce micro-adhesion of bacteria, an abrasive in an amount sufficient to mechanically remove debris from a tooth surface and debride plaque, and an artificial sweetener in an amount sufficient to adjust the flavor of the tablet when chewed by a user.

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Номер записи: 18
12-07-2012 дата публикации

Oral disinfectant, and food additive comprising the disinfectant

Номер: US20120177624A1
Автор: Ayako Horigome, Koji Yamauchi, Kouichirou Shin
Принадлежит: Morinaga Milk Industry Co Ltd

Disclosed is a disinfectant which is safe, has few adverse side-effects, can be ingested together with a food or beverage by adding the disinfectant to the food or beverage, shows a bactericidal effect in the oral cavity, and has no problem even when ingested on a daily basis over a long period. Also disclosed is a food additive comprising the disinfectant. Specifically, disclosed is an oral disinfectant for the disinfection of an oral bacterium, which comprises lactoperoxidase, glucose oxidase, glucose and a pH-adjusting component.

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Номер записи: 19
26-07-2012 дата публикации

Tooth whitening strips

Номер: US20120189680A1
Автор: Douglas Craig Scott, Paul Albert Sagel, Robert Eugene Barron, Robert Woodrow Gerlach, Stephen Francis Mcclanahan
Принадлежит: Individual

A tooth whitening product is provided. The tooth whitening product includes film formed from a water hydratable polymer and a plasticizer. The film has a first side and a second side and a tooth whitening agent applied as coating to one side of the film.

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Номер записи: 20
16-08-2012 дата публикации

Low water stannous fluoride plus zinc citrate dentifrice with improved stability, rheology, and efficacy

Номер: US20120207686A1
Автор: Linh Fruge, Michael Prencipe, Steven Wade Fisher
Принадлежит: Colgate Palmolive Co

A dentifrice composition having a low water phase comprising effective amounts of polyphosphate and ionic active ingredients.

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Номер записи: 21
06-09-2012 дата публикации

System And Method For Packet Profiling

Номер: US20120227109A1
Автор: Jeffrey D. DIMURO
Принадлежит: JPMorgan Chase Bank NA

Systems and methods for packet profiling are disclosed. According to one embodiment, a method for profiling incoming data packets for an organization includes the steps of (1) receiving, at an interface for a transport provider, a data packet; (2) using a computer processor, analyzing the data packet; (3) using the computer processor, based on the analysis, marking the data packet; and (4) transmitting the data packet to the organization.

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Номер записи: 22
13-09-2012 дата публикации

Novel Polymorphs of Rebaudioside C and Methods for Making and Using the Same

Номер: US20120230922A1
Автор: F. Raymond Salemme, Robert A. Daines
Принадлежит: Linguagen Corp

Embodiments of this invention encompass a method for producing and purifying rebaudioside C. In particular, this invention relates to a method for purifying rebaudioside C compositions to obtain a substantially pure rebaudioside C product using one or more crystallization steps. Resulting polymorphic forms of rebaudioside C, substantially pure rebaudioside C compositions and their uses are disclosed.

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Номер записи: 23
20-09-2012 дата публикации

Anti-bacterial oral care composition and method for producing the same

Номер: US20120237457A1
Автор: Ho-Yi Tsai, Shu-Cheng CHEN
Принадлежит: VA&G BIOSCIENCE Inc

An anti-bacterial oral care composition and method for producing the same are disclosed. The composition comprises chitosan, organic acid, bioflavonoids and xylitol that are mixed together and can effectively inhibit the growth of bacteria in oral cavity, such as 99.9% of staphylococcus aureus, 99.9% of streptococcus mutans, 99.9% of candida albicans, thus reducing the occurrence of decayed tooth. Furthermore, no chemical preservative and anti-bacterial agent are added in the composition, reducing the damage to the oral mucosa and the health of the user.

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Номер записи: 24
27-09-2012 дата публикации

Process for the preparation of aromatized chewing foams for cosmetic products

Номер: US20120244201A1
Автор: Claudia Letmathe, Dirk Schwannecke, Gabriele Rohé, Hartwig Kempkes, Jens Hepperle, Meike Niesten, Sebastian Dörr, Steffen Hofacker, Thorsten KRÄMER, Thorsten Rische
Принадлежит: BAYER MATERIALSCIENCE AG

The invention relates to a process for the preparation of novel aromatized chewing foams for the oral care sector based on polyurethane-polyureas and aromatizing compositions.

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Номер записи: 25
11-10-2012 дата публикации

Oral care compositions for use with an oral light device

Номер: US20120258053A1
Автор: Madhusudan Patel, Mahmoud Hassan, Rosa Paredes, Thomas Boyd
Принадлежит: Colgate Palmolive Co

Generally regarded as safe (GRAS) dyes can be used as photosensitizing dyes in oral compositions to provide anti-bacterial and anti-inflammatory efficacy. Embodiments include oral care compositions including photosensitizing dyes, methods of making the compositions, methods of using the compositions, and kits containing the compositions and light emitting devices.

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Номер записи: 26
25-10-2012 дата публикации

Composition, use, and preservation method

Номер: US20120269739A1
Автор: Geraldine Lerebour, Maria Dalko, Sylvie Cupferman
Принадлежит: LOreal SA

The invention relates to a cosmetic, pharmaceutical, dermatological, nutraceutical or oral cosmetic composition having, as main preserving system, a mild preserving system formed from compounds with a broad antimicrobial spectrum, which have only one pKa, the said pKa being greater than or equal to 10, the said mild preserving system being present in a content strictly greater than or equal to 1% by weight relative to the weight of the said composition. The invention also relates to the use, in a cosmetic, dermatological or pharmaceutical composition, of at least one compound of formula (I), as a preserving agent:

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Номер записи: 27
25-10-2012 дата публикации

Lipid depot formulations

Номер: US20120269772A1
Автор: Fredrik Joabsson, Fredrik Tiberg, Ian Harwigsson, Krister Thuresson, Markus Johansson, Markus Johnsson
Принадлежит: CAMURUS AB

The present invention relates to pre-formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The preformulations are suitable for generating parenteral, non-parenteral and topical depot compositions for sustained release of active agents. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.

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Номер записи: 28
15-11-2012 дата публикации

Fluoride free and anionic surfactant free dentifrice having a high micro efficacy

Номер: US20120288453A1
Автор: Barbara Hepler, Kimdra Smith-Webster, Linh Fruge, Michael Collins
Принадлежит: Individual

An oral care composition and method are described in which the composition is free of an anionic surfactant and a fluoride source.

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Номер записи: 29
29-11-2012 дата публикации

Peroxide-stabilized abrasive tooth whitening compositions, process for preparing and method of use

Номер: US20120301522A1
Автор: David Rees, David Vaughan Palmer, Robert J. Corring, William E. Prosise
Принадлежит: ISP Investments LLC

Disclosed herein is a water-based, peroxide-stabilized, abrasive tooth whitening composition comprising: (i) a peroxide-polymer complex comprising (a) a peroxide component or a peroxide generating component; and (b) a vinyl lactam based polymer; (ii) coated abrasive particles; and one or more orally acceptable carriers. This application also provides methods for whitening the tooth surfaces by contacting with the compositions. Additionally disclosed is a process for preparing the compositions.

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Номер записи: 30
06-12-2012 дата публикации

Composition for cleaning teeth comprising natural glass and related methods

Номер: US20120308626A1
Автор: BO Wang
Принадлежит: Imerys Filtration Minerals Inc

A composition for cleaning teeth may include natural glass, wherein the natural glass has a top particle size (d 90 ) less than 50 μm and a median particle size (d 50 ) less than 30 μm, and wherein the natural glass ranges from 0.1 percent to 20 percent by weight of the composition. A natural glass composition may have a top particle size (d 90 ) less than 50 μm, a median particle size (d 50 ) less than 30 μm, and exhibit an RDA value less than 220. The composition for cleaning teeth may include a toothpaste base.

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Номер записи: 31
13-12-2012 дата публикации

Compositions for oral use and methods for treating the oral mucosa, lips, and perioral regions

Номер: US20120315223A1
Автор: Jose E. Ramirez
Принадлежит: Individual

Compositions containing polymetal complexes useful in treating disorders of the oral mucosa, lips, and perioral regions are described.

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Номер записи: 32
20-12-2012 дата публикации

Inhibition of biofilm formation by 1,2,3,4,6-penta-o-galloyl-d-glucopyranose

Номер: US20120321566A1
Автор: Fang-Rong Chang, Hung-Wei Yang, Mei-Hui Lin, Mu-Yi Hua, Shih-Tung Liu
Принадлежит: Chang Gung University CGU

Disclosed herein are an anti-biofilm composition and a method to inhibit or prevent cell adhesion and/or biofilm formation by a microorganism, in which use of 1,2,3,4,6-penta-O-galloyl-D-glucopyranose (PGG) is involved therein.

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Номер записи: 33
20-12-2012 дата публикации

Liquid cleaning and/or cleansing composition

Номер: US20120321567A1
Автор: Aicha Dkidak, Denis Alfred Gonzales, Martin Ian James
Принадлежит: Procter and Gamble Co

The present invention relates to a liquid, cleaning and/or cleansing composition comprising biodegradable abrasive cleaning particles.

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Номер записи: 34
20-12-2012 дата публикации

Process for producing (3s)-i-menthyl 3-hydroxybutyrate and sensate composition

Номер: US20120321773A1
Автор: Kazuma HOJO, Kenya Ishida, Takashi Aida
Принадлежит: Takasago International Corp

Disclosed is a cooling component or sensate component which does not have undesirable stimulus feeling, bitterness and the like and is excellent in the persistence of refresh-feeling and cool-feeling, a sensate composition which comprises the same, and various products that comprise said sensate composition. Also disclosed is a cooling agent comprising (3S)-l-menthyl 3-hydroxybutyrate represented by the following formula (I)

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Номер записи: 35
17-01-2013 дата публикации

Oral care composition

Номер: US20130017238A1
Автор: Andre Morgan, Michael Prencipe, Sarita Mello, Venda Porter
Принадлежит: Colgate Palmolive Co

Disclosed are oral care compositions, for example dentifrice compositions, comprising an orally acceptable vehicle, metal oxide particles having an average particle size of no greater than a dentin tubule and a polymeric adherent material for adhering the metal oxide particles in the dentin tubule. The metal oxide particles have a median particle size of 5 microns or less, and may comprise zinc oxide.

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Номер записи: 36
28-02-2013 дата публикации

Adhesive slow-release formulations for the local administration of curcumin

Номер: US20130052145A1
Автор: Andreas Obwaller
Принадлежит: Orphanidis Pharma Research GmbH

Through the combined use of solvents with polyacrylic acid, it is possible to produce curcumin formulations that are stable in liquid form, while having both mucoadhesive and slow-release properties and ensure a solubility of the active ingredient of up to 15% (w/v).

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Номер записи: 37
07-03-2013 дата публикации

Aldehyde-removing composition

Номер: US20130058887A1
Автор: Haruhiko Yamaguchi, Miho Hosoya, Toru Nakayama
Принадлежит: Tohoku University NUC

An object of the present invention is to provide a composition for removing aldehyde. Specifically, the present invention relates to an aldehyde-removing composition comprising a microorganism belonging to the genus Gluconobacter having aldehyde-degrading activity, or extracts thereof or disrupted cells thereof, wherein the microorganism belonging to the genus Gluconobacter has higher aldehyde-degrading activity than aldehyde-generating activity.

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Номер записи: 38
14-03-2013 дата публикации

Oral care compositions resistant to microbial growth

Номер: US20130064779A1
Автор: Enzo Toshio Utima, Erico Vieira Prat, Fernanda Cristina Geraldo Correa, Katrin Chaves Da Costa, Michael Prencipe, Odete Tieko Yamane, Richard Scott Robinson, Sandra Pereira Ramos
Принадлежит: Colgate Palmolive Co

Described herein are compositions which prevent the growth of bacteria resistant to high salt concentrations, methods of preparing the same, and methods of using the same.

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Номер записи: 39
21-03-2013 дата публикации

HIGH-PURITY STEVIOL GLYCOSIDES

Номер: US20130071339A1
Автор: MARKOSYAN Avetik
Принадлежит:

Methods of preparing highly purified steviol glycosides, particularly Rebaudioside D, are described. The methods include purification from the extraction stage of the Bertoni plant, purification of steviol glycoside mixtures, Rebaudioside D and Rebaudioside A from a commercial Stevia extract, and purification of Rebaudioside D from remaining solutions obtained after isolation and purification of Rebaudioside A and a high purity mixture of steviol glycosides. The methods are useful for producing high purity Rebaudioside D, Rebaudioside A, and steviol glycoside mixtures. The high purity steviol glycosides are useful as non-caloric sweeteners in edible and chewable compositions such as any beverages, confectioneries, bakery products, cookies, and chewing gums. 1. A method for purifying steviol glycosides , comprising the steps of:a. providing a solution of steviol glycosides;b. passing the solution of steviol glycosides through a multi-column system including a plurality of columns packed with an adsorbent resin, to obtain at least one column having adsorbed steviol glycosides;c. removing impurities from the multi-column system; andd. eluting the adsorbed steviol glycosides from the at least one column, to obtain an eluted solution comprising steviol glycosides.2. The method of claim 1 , wherein impurities are removed by eluting the multi-column system with a washing solution.3. The method of claim 2 , wherein the washing solution comprises an aqueous alcohol solution having a water to alcohol ratio ranging from about 99.9:0.1 to about 60:40.4. The method of claim 1 , wherein the adsorbed steviol glycosides are eluted with an aqueous alcohol solution having a water to alcohol ratio ranging from about 60:40 to about 0.1:99.9.5. The method of claim 1 , wherein at least two columns of the plurality of columns are connected in series.6. The method of claim 1 , wherein at least two columns of the plurality of columns are connected in parallel.7. The method of claim 1 , ...

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Номер записи: 40
21-03-2013 дата публикации

Breath freshening confectionery products and methods of making and using same

Номер: US20130071454A1
Автор: Barbara Z. Stawski, Gordon N. McGrew, James C. Clark, Michael S. Haas, Miguel Perez, Philip M. Soukup, Thomas M. Mindak
Принадлежит: Wm Wrigley Jr Co

A confectionery product comprises a first side and a second side generally opposite to the first side; the second side comprising an abrasive surface that is suitable for scrubbing the top surface of a tongue within the oral cavity. In preferred embodiments the first side is smooth, and may be domed shaped and generally fit the roof of the mouth. The abrasive surface may be provided by 1) a formed, uneven surface, 2) by including abrasive particles in the composition making up the second surface, or 3) a combination of a formed, uneven surface and abrasive particles. The confectionery product is preferably a hard confectionery, but may also be a chewing gum product. A preferred confectionery product comprises a second side with a width and a length, the smallest of which is at least 1.6 times the product thickness. Preferred pressed tablets are made from a compressible composition and have at least one abrasive surface suitable for cleaning the surface of a human tongue in an oral cavity and have a hardness of between about 18 Kp and about 35 Kp.

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Номер записи: 41
21-03-2013 дата публикации

SOLID CORE COACERVATED CAPSULES

Номер: US20130071455A1
Автор: Dardelle Gregory
Принадлежит: FIRMENICH SA

Coacervated capsules that have from 10 to 99% by weight of the capsule of a core comprising a mixture of (I) a fatty component of (i) hydrogenated oil or (ii) hydrogenated fat or (iii) cocoa butter or (iv) a mixture thereof and (II) a material to be encapsulated comprising a flavor and/or fragrance material, the mixture having a Tm of between about 30° C. and about 40° C. such that it is a solid at 20° C., wherein the weight ratio of fatty component to material to be encapsulated is from to 10:90 to 70:30, and from 90 to 1% by weight of the capsule of a coating layer of a protein, and optionally a non-protein polymer. Also, methods of manufacture and use of such capsules and food and oral care compositions containing such capsules. 1. A coacervated capsule comprising:(a) from 10 to 99% by weight of the capsule of a core comprising a mixture of (I) a fatty component comprising (i) hydrogenated oil or (ii) hydrogenated fat or (iii) cocoa butter or (iv) a mixture thereof, and (II) a material to be encapsulated comprising a flavor and/or fragrance material, the mixture having a Tm of between about 30° C. and about 40° C. such that it is a solid at 20° C., wherein the weight ratio of fatty component to material to be encapsulated is from to 10:90 to 70:30, and(b) from 90 to 1% by weight of the capsule of a coating layer comprising essentially a protein, and optionally a non-protein polymer.2. The capsule according to claim 1 , wherein the flavor or a fragrance is a hydrophobic liquid.3. The capsule according to claim 1 , wherein the protein is gelatine.4. The capsule according to claim 1 , wherein the non-protein polymer is gum Arabic.58.-. (canceled)9. A food composition that includes coacervated capsules as claimed in in a flavor effective amount therein.10. An oral care composition that includes coacervated capsules as claimed in in a flavor effective amount therein.11. A body care claim 1 , skin care or home care product that includes coacervated capsules as claimed ...

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Номер записи: 42
21-03-2013 дата публикации

ENCAPSULATION OF INGREDIENTS IN LACTOSE MATRIX TO FORM ACTIVE ENCAPSULATES

Номер: US20130071456A1
Автор: Boyd Thomas, Collins Michael, Fruge Linh, Hepler Barbara
Принадлежит: Colgate-Palmolive Company

An oral care composition and method are described in which the composition includes lactose matrix encapsulates entrained in a carrier. The encapsulates may further comprise oral care and/or personal care ingredients. 1. An encapsulate composition comprising:at least one oral care and/or personal care ingredient encapsulated in a matrix comprising:a lactose monohydrate; anda microcrystalline cellulose, wherein the lactose monohydrate is present in an amount of 50% to 75% by weight.2. The encapsulate of claim 1 , wherein the encapsulate further comprises a coloring agent.3. The encapsulate of claim 2 , wherein the coloring agent comprises at least one coloring agent chosen from titanium dioxide claim 2 , a dye claim 2 , a pigment claim 2 , a colorant claim 2 , or an opacifying agent.4. The encapsulate of claim 1 , wherein the at least one oral care and/or personal care ingredient comprises at least one ingredient chosen from of zinc citrate claim 1 , stannous fluoride claim 1 , cetylpyridinium chloride claim 1 , and L-arginine.5. (canceled)6. The encapsulate of claim 1 , wherein the microcrystalline cellulose is present in an amount of 25% to 40% by weight.7. The encapsulate of claim 3 , wherein the titanium dioxide is present in an amount of 0.1% to 2% by weight.8. The encapsulate of claim 1 , wherein the at least one oral care and/or personal care ingredient is present in an amount of 0.1% to 50% by weight.9. The encapsulate of claim 1 , wherein the encapsulate has a size of 0.5 mm to 5 mm in diameter.10. The encapsulate of claim 1 , wherein the encapsulate contains a combination of lactose monohydrate and microcrystalline cellulose such that when used in an oral care composition claim 1 , the encapsulate is capable of dissolving in the oral cavity during the use of the oral care composition to release an ingredient to the oral cavity.11. A composition comprising the encapsulate composition of and a carrier.12. The composition of claim 10 , wherein the carrier is ...

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Номер записи: 43
28-03-2013 дата публикации

ADHESIVE DENTAL BLEACHING COMPOSITIONS CONTAINING POLYVINYLPYRROLIDONE

Номер: US20130078195A1
Автор: Chen Tianming
Принадлежит: ULTRADENT PRODUCTS, INC.

A dental bleaching composition comprises a dental bleaching agent and a polyvinylpyrrolidone thickening agent. The bleaching composition may include water, flavoring agents, a basic substance and desensitizing agents, as desired. Polyvinylpyrrolidone avoids acid etching and chelation of teeth that were problematic in bleaches using carbomer as a thickener. A delivery system for delivering the bleaching composition comprises the aforementioned dental bleaching composition in combination with a moisture-resistant barrier layer such as a dental tray or a flexible strip of material. 1. An adhesive one-part dental bleaching composition for bleaching a person's teeth , comprising:a dental bleaching agent selected from the group consisting of hydrogen peroxide, carbamide peroxide, sodium perborate, sodium percarbonate, and combinations thereof;water in an amount of at least 0.1% by weight of said dental bleaching composition; andpolyvinylpyrrolidone included in an amount of at least about 10% by weight so that said dental bleaching composition is highly viscous and adhesive when applied to a person's teeth.2. An adhesive one-part dental bleaching composition as in claim 1 , said polyvinylpyrrolidone comprising at least about 25% by weight of the dental bleaching composition.3. An adhesive one-part dental bleaching composition as in claim 1 , said polyvinylpyrrolidone having a molecular weight in a range of about 90 claim 1 ,000 to about 1 claim 1 ,500 claim 1 ,000.4. An adhesive one-part dental bleaching composition as in claim 1 , said polyvinylpyrrolidone having a molecular weight in a range of about 1 claim 1 ,000 claim 1 ,000 to about 1 claim 1 ,500 claim 1 ,000.5. An adhesive one-part dental bleaching composition as in claim 1 , wherein said tooth adhesion agent is included in an amount that exceeds an amount of said dental bleaching agent in the dental bleaching composition.6. An adhesive one-part dental bleaching composition as in claim 1 , said water having a ...

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Номер записи: 44
28-03-2013 дата публикации

DENTAL STERILIZING WATER, METHOD FOR PRODUCING THE WATER, AND DEVICE FOR PRODUCING THE WATER

Номер: US20130078196A1
Автор: NOGUCHI Munenori
Принадлежит: PERFECT PERIO CO., LTD.

This aims to produce dental sterilizing water having not only a sterilizing action but also an action to break a bio-film. Provided is a sterilizing water producing device () comprising a stock solution tank () for storing a stock solution (), a stroke pump () connected in communication to the stock solution tank, an electrolytic bath () connected in communication to the stroke pump, a discharge pipe () connected in communication to the electrolytic bath, and a dilution water tank () reserving dilution water (). The dilution water tank () is so positioned relative to the tip position of the discharge pipe () that the tip of the discharge pipe () may be lower than the water level of the dilution water () reserved in the dilution water tank (). The stock solution () is prepared by selecting any of the methods shown at (a-1) to (d). 131-. (canceled)32. A method for producing dental sterilizing water comprising preparing an aqueous stock solution containing sodium chloride and carbon dioxide; and electrolyzing the aqueous stock solution so that the effective chlorine concentration is from 50 to 700 ppm , the pH is from 6.3 to 8 , and hypochlorous acid and sodium hydrogen carbonate are produced.33. The method for producing dental sterilizing water according to claim 32 , wherein the aqueous stock solution is prepared by forcing water to pass through a reverse osmosis membrane; adding sodium chloride to the passed water; and either blowing carbon dioxide gas into the water or adding dry ice to the water before claim 32 , after claim 32 , or simultaneously with claim 32 , the step of adding sodium chloride to the water.34. The method for producing dental sterilizing water according to claim 32 , wherein the aqueous stock solution is prepared by adding sodium chloride to purified or distilled water; and either blowing carbon dioxide gas into the water or adding dry ice to the water before claim 32 , after claim 32 , or simultaneously with claim 32 , the step of adding ...

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Номер записи: 45
28-03-2013 дата публикации

Therapeutic oral composition

Номер: US20130078197A1
Автор: Evangelia Arvanitidou, Sarita V. Mello
Принадлежит: Colgate Palmolive Co

Disclosed are therapeutic oral compositions useful in the treatment of a variety of oral disorders, in which the composition can provide blockage of dentinal tubes, while at the same time provide antibacterial and anti-caries efficacy. The compositions include arginine in free or salt form, a mucoadhesive polymer, and at least one component selected from pyrophosphates, zinc salts, potassium salts, strontium salts, and mixtures thereof.

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Номер записи: 46
28-03-2013 дата публикации

NOVEL USE

Номер: US20130078198A1
Автор: Aitken Gail Cameron, Churchley David Raymond
Принадлежит: Glaxo Group Limited

This invention relates to the use of sodium dodecylbenzene sulphonate (SDDBS) for helping to prevent or remove surface deposited stains from natural teeth and dental prostheses and oral care compositions comprising SDDBS for such use. 1. An oral care composition comprising sodium dodecylbenzene sulphonate (SDDBS) for use in combating stain from a dental surface.2. A composition according to further comprising a source of zinc ions.3. A composition according to wherein the source of zinc ions is selected from zinc chloride claim 2 , zinc citrate claim 2 , zinc acetate claim 2 , zinc sulphate claim 2 , zinc gluconate claim 2 , zinc salicylate claim 2 , zinc lactate claim 2 , zinc malate claim 2 , zinc maleate claim 2 , zinc tartrate claim 2 , zinc carbonate claim 2 , zinc zinc phosphate claim 2 , zinc oxide or zinc sulphate.4. A composition according to wherein the source of zinc ions is zinc chloride.5. A composition according to further comprising 4-isopropyl-3-methylphenol (IPMP).6. A composition according to which is a mouthwash or a toothpaste.7. A composition according to which is a mouthwash.8. (canceled)9. A method for combating stain from a dental surface claim 1 , said method comprising applying an oral care composition comprising an effective amount of SDDBS to the dental surface. This invention relates to the use of sodium dodecylbenzene sulphonate (SDDBS) for combating (ie helping to prevent or remove) surface deposited stains from natural teeth and dental prostheses and oral care compositions comprising SDDBS for such use. Suitable compositions include mouthwash and dentifrice compositions.Several factors contribute to tooth discoloration but the three main factors are believed to be: i) formation of plaque and tartar matrices on the tooth surface which then entraps stains, ii) ingestion of certain drugs during tooth formation, and iii) discoloration due to oral cavity traumatization following which blood break-down products seep into the mineralized ...

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Номер записи: 47
04-04-2013 дата публикации

ORAL CARE COMPOSITIONS

Номер: US20130084253A1
Автор: Brading Melanie Gayle, Golding Stephen, Green Alison Katharine, Littlewood David Thomas, Scott Ann Elizabeth
Принадлежит:

The invention provides an oral care composition (preferably a dentifrice) comprising one or more curcumin compounds and a source of zinc ions. The incorporation of a source of zinc ions into the composition suppresses the degradation and/or discoloration of the curcumin compound(s) in the composition. 1. An oral care composition comprising one or more curcumin compounds and a source of zinc ions.2. An oral care composition according to claim 1 , in which the curcumin compound is a mixture of tetrahydrocurcumin claim 1 , tetrahydrodemethoxycurcumin and tetrahydrobis-demethoxycurcumin.3. An oral care composition according to claim 1 , in which the source of zinc ions is zinc citrate.4. An oral care composition according to claim 1 , which is in the form of a dentifrice and which comprises abrasive cleaning agent claim 1 , water claim 1 , humectant claim 1 , binder or thickening agent claim 1 , and surfactant.5. The use of a source of zinc ions for suppressing the degradation and/or discoloration of curcumin compound(s) in an oral care composition. The present invention is concerned with oral care compositions. More particularly, the present invention is concerned with oral care compositions containing curcumin compounds.Curcumin compounds have antioxidant properties and may be used in oral care compositions to exert beneficial physiological effects, such as prevention or amelioration of gingivitis or periodontitis. GB 2317339 discloses oral compositions for prevention and treatment of dental caries, periodontal diseases and other diseases of the oral cavity. The compositions include a curcuminoid and a fluoride ion source, in combination with oral care actives and carrier materials. SU 1,132,945 discloses incorporating extracts of turmeric or ginger into toothpaste compositions for improved anti-inflammatory effect on tissues of the oral cavity and treatment of certain diseases of the mucous membranes of the oral cavity and marginal periodontitis.However, the ...

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Номер записи: 48
04-04-2013 дата публикации

Low Calorie Composite Sweetener As Sugar Alternative And Methods For Producing The Same

Номер: US20130084317A1
Автор: Avetik Markosyan, Siddhartha Purkayastha
Принадлежит: PureCircle Sdn Bhd

The invention provides a process for producing a low calorie composite sweetener as a sugar alternative. The invention further provides a low calorie composite sweetener that can be used in many products. The low calorie composite sweetener is useful as non-caloric sweeteners in edible and chewable compositions such as any beverages, confectionaries, bakeries, cookies, chewing gums, and alike.

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Номер записи: 49
11-04-2013 дата публикации

ORAL CARE COMPOSITIONS AND METHODS

Номер: US20130089506A1
Автор: Brown James R., Trivedi Harsh M., Vazquez Joe, Wang Wei
Принадлежит: Colgate-Palmolive Company

Disclosed are oral care compositions and the use of such oral care compositions for inhibiting co-aggregation of oral bacteria and inhibiting bacterial growth. Also disclosed are methods for inhibiting co-aggregation of oral bacteria and inhibiting bacterial growth. The oral care composition includes cranberry extract non-dialyzable material, in which the cranberry extract non-dialyzable material is present in an amount effective to inhibit co-aggregation of oral bacteria and/or inhibit bacterial growth. 1) An oral care composition comprising cranberry extract non-dialyzable material and an orally acceptable vehicle , wherein the cranberry extract non-dialyzable material is present in a concentration of 0.08-1.33 mg/ml , and wherein the composition does not contain a component that deactivates the cranberry extract non-dialyzable material.2) An oral care according to claim 1 , wherein the cranberry extract non-dialyzable material is present in the composition in a concentration of about 0.3% w/w.3) An oral care composition according to claim 1 , wherein the orally acceptable vehicle is selected from one or more of the group consisting of water claim 1 , alcohol claim 1 , a humectant claim 1 , and combinations thereof.4) An oral care composition according to claim 3 , wherein the alcohol is ethanol.5) An oral care composition according to claim 4 , wherein the alcohol is present in a concentration of about 6% w/w.6) An oral care composition according to claim 3 , wherein the humectant is selected from the group consisting of one or more of sorbitol claim 3 , glycerine claim 3 , and mixtures thereof.7) An oral care composition according to claim 6 , wherein the humectant is present in a concentration of about 10% w/w.8) An oral care composition according to claim 1 , wherein the composition is a mouthrinse.9) An oral care composition according to claim 1 , wherein the composition further comprises one or more agents selected from the group consisting of an anti-plaque ...

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Номер записи: 50
11-04-2013 дата публикации

AGENT FOR REDUCING ACETALDEHYDE IN ORAL CAVITY

Номер: US20130089535A1
Автор: Koyama Takahumi, Yamashiro Kan
Принадлежит: AMANO ENZYME INC.

Disclosed herein is a novel enzymatic agent effective in reducing acetaldehyde in the oral cavity. It has been found that an aldehyde dehydrogenase derived from a microorganism belonging to the genus and a threonine aldolase derived from are effective in reducing low concentrations of acetaldehyde. Therefore, an agent for reducing acetaldehyde in the oral cavity is provided, which contains these enzymes as active ingredients. 1. An agent for reducing acetaldehyde in an oral cavity , comprising an aldehyde dehydrogenase or a threonine aldolase.2Saccharomyces.. The agent for reducing acetaldehyde in an oral cavity according to claim 1 , wherein the aldehyde dehydrogenase is derived from a microorganism belonging to the genus3SaccharomycesSaccharomyces cerevisiae.. The agent for reducing acetaldehyde in an oral cavity according to claim 2 , wherein the microorganism belonging to the genus is4Escherichia coli.. The agent for reducing acetaldehyde in an oral cavity according to claim 1 , wherein the threonine aldolase is derived from5. The agent for reducing acetaldehyde in an oral cavity according to claim 1 , which exhibits degradation activity against acetaldehyde at a substrate concentration of 1 μM to 1 mM.6. The agent for reducing acetaldehyde in an oral cavity according to claim 1 , which exhibits degradation activity against acetaldehyde at a substrate concentration of 1 μM to 100 μM.7. An oral composition comprising the agent for reducing acetaldehyde in an oral cavity according to .8. A method for reducing acetaldehyde in saliva claim 7 , comprising allowing the oral composition according to to act on saliva.9. The method according to claim 8 , which is effective in reducing oral odor.10. The method according to claim 8 , which is effective in preventing cancer whose cause or one of causes is acetaldehyde. The present invention relates to an agent for reducing acetaldehyde in the oral cavity. More specifically, the present invention relates to an agent that ...

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Номер записи: 51
11-04-2013 дата публикации

Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses

Номер: US20130090391A1
Автор: Maurice Gerard Lynch, Michael SESTRICK, Thomas Ruszkay, Zheng Tan
Принадлежит: FMC Corp

Methods of making a high gel strength, water-dispersible, stabilizing colloidal microcrystalline cellulose composition are disclosed. This stabilizer composition is useful in many food and non-food applications.

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Номер записи: 52
18-04-2013 дата публикации

NON-AQUEOUS ORAL CARE COMPOSITIONS

Номер: US20130095045A1
Автор: GROVES Brian Joseph, WATERFIELD Philip Christopher
Принадлежит:

The invention provides a non-aqueous oral care composition with a liquid continuous phase comprising a thickening agent, a humectant, and one or more liquid polyethylene glycols having a melting point below 25° C., in which the liquid continuous phase is structured with crystals of one or more solid polyethylene glycols having a melting point of 25° C. or above. The rheological behaviour of the composition of the invention corresponds well with the characteristic rheological behaviour of typical aqueous dentifrice formulations. 1. A non-aqueous oral care composition with a liquid continuous phase comprising a thickening agent , a humectant , and one or more liquid polyethylene glycols having a melting point below 25° C. , in which the liquid continuous phase is structured with crystals of one or more solid polyethylene glycols having a melting point of 25° C. or above.2. A composition according to claim 1 , in which the carboxyvinyl polymer has a molecular weight of at least 750 claim 1 ,000 g/mol.3. A composition according to claim 1 , in which the carboxyvinyl polymer is selected from homopolymers of acrylic acid cross-linked with allyl ethers of sucrose or pentaerythritol; and homopolymers of acrylic acid cross-linked with divinyl glycol.4. A composition according to claim 1 , in which the humectant is one or more organic polyols having 3 or more hydroxyl groups in the molecule.5. A composition according to claim 1 , in which the solid polyethylene glycol has a melting point ranging from 35 to 65° C.6. A composition according to claim 1 , in which the solid polyethylene glycol has the general formula H(OCHCH)OH claim 1 , where n is the number of repeating oxyethylene units claim 1 , and the average value of n ranges from 60 to 75.7. A composition according to claim 1 , in which the liquid polyethylene glycol has a melting point ranging from −15 to 8° C.8. A composition according to claim 1 , in which the liquid polyethylene glycol has the general formula H(OCHCH) ...

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Номер записи: 53
18-04-2013 дата публикации

Topical vitamin d and ubiquinol oral supplement compositions

Номер: US20130095155A1
Автор: Dale G. Brown, William A. Mchale
Принадлежит: Premier Dental Products Co

A topical vitamin D and UBIQUINOL supplement composition useful in treating oral inflammation and reducing oxidative stress comprising: a supplement mixture of vitamin D and UBIQUINOL in an aqueous-free emulsion containing: spilanthes extract, stabilizing compositions for UBIQUINOL and trans-oral mucosal absorption facilitators for the supplement mixture; where the emulsion forms a mucoadhesive gel in the presence of saliva, that effects passive diffusion through the oral mucosa of the supplement mixture and spilanthes extract regulating: in vivo availability and immune response of the supplement mixture, and maintaining adequate levels of circulating vitamin D and of adjunctively administered UBIQUINOL, while minimizing the risk of hypercalcemia.

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Номер записи: 54
18-04-2013 дата публикации

FLAVOR RELEASE FROM MULTILAYER FILM DURING BRUSHING

Номер: US20130095159A1
Автор: Boyd Thomas, Gu Ben, Lin Nora, Wang Wei
Принадлежит: Colgate-Palmolive Company

Oral care compositions which provide enhanced flavour release, and which comprise a multilayer film and an orally acceptable carrier. The carrier contains a first flavour and the film has a centre layer containing a second flavour disposed between two outer surface layers. The first and second flavours may be identical or different. Each layer for the film may comprise a film forming polymer, e.g. hydroxypropylmethyl cellulose. The outer layers may comprise a release modulating agent, e.g. polyvinyl acetate or hydroxyethyl cellulose. The carrier may be a dentifrice or mouthwash. 1. An oral care composition having enhanced flavor release comprisingan orally acceptable carrier containing a first flavor; anda multilayer film, the multilayer film including a center layer disposed between two outer surface layers;wherein said center layer contains a second flavor.2. The composition of claim 1 , wherein each layer comprises a film forming polymer.3. The composition of claim 2 , wherein the film forming polymer is selected from hydroxypropylmethyl cellulose claim 2 , methyl cellulose claim 2 , hydroxypropyl cellulose and mixtures of copolymers thereof.4. The composition of claim 2 , wherein the film forming polymer comprises from about 25% to about 75% by weight of the multilayer film.5. The composition of claim 1 , wherein at least one of said outer surface layers further comprise a release modulating agent.6. The composition of claim 5 , wherein the release modulating agent is polyvinyl acetate or hydroxyethyl cellulose.7. The composition of claim 5 , wherein the release modulating agent comprises from about 5% to about 30% by weight of the multilayer film.8. The composition of claim 1 , wherein the orally acceptable carrier is a dentifrice or a mouthwash.9. The composition of claim 1 , wherein the thickness of each outer surface layer is from about 0.1 mils to about 4 mils.10. The composition of claim 9 , wherein the thickness of each outer surface layer is from about 0 ...

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Номер записи: 55
25-04-2013 дата публикации

Composition for treating and/or preventing periodontal disease

Номер: US20130101529A1
Автор: KAWABE Mitsuo, Tsuchida Kotarou, TSUCHIDA Yuuzou, Watanabe Kunitomo
Принадлежит:

A method for preventing periodontal disease, which comprises administering an effective amount of a composition to a method for preventing periodontal disease comprising administering an effective amount of a composition to a part in an oral cavity before a periodontal disease-related bacteria, a decayed teeth-related bacteria, and/or spp. is/are abnormally proliferated in the oral cavity, wherein said composition comprises a extract and malic acid. 1. A method for preventing periodontal disease comprising:{'i': 'Candida', 'administering an effective amount of a composition to a part in an oral cavity before a periodontal disease-related bacteria, a decayed teeth-related bacteria, and/or spp. is/are abnormally proliferated in the oral cavity,'}{'i': 'Sasa', '(a) wherein said composition comprises a extract and malic acid,'}{'i': 'Sasa', '(b) wherein said extract is prepared by extracting raw leaves or dried leaves with water,'}{'i': 'Sasa', '(c) wherein said extract is contained in a concentration as expressed in terms of the solid content ranging from 2 to 25% by mass, and'}(d) wherein said malic acid is contained in a concentration of from 0.01 to 5% by mass.2. The method according to claim 1 , wherein the composition is administered in an amount of 0.01 to 0.1 g/1 kg of body weight claim 1 , at a frequency of 1 to 5 times a day.3. The method according to claim 1 , wherein the composition is administered in an amount of 0.1 to 1 g claim 1 , at a frequency of 1 to 5 times a day.4. The method according to claim 1 , wherein said malic acid is contained in a concentration of from 0.02 to 3% by mass.5. The method according to claim 2 , wherein said malic acid is contained in a concentration of from 0.02 to 3% by mass.6. The method according to claim 1 , wherein said composition further comprises an oily component and a creaming agent claim 1 ,said oily component is at least one member selected from the group consisting of squalane, tallow, lard, horse fat, lanolin, ...

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Номер записи: 56
25-04-2013 дата публикации

MULTILAYER FILMS FOR DELIVERY OF FLAVOR

Номер: US20130101652A1
Автор: Boyd Thomas, Gu Ben, Leigh Leonora
Принадлежит:

An oral care composition having enhanced flavor release comprising an orally acceptable carrier containing a first flavor and a multilayer film for extended or delayed flavor release, the multilayer film including at least a center layer containing a second flavor, the center layer positioned between two outer surface layers, each surface layer including a release modulating agent, the first and second flavor being the same or different. The film is adapted to adhere to an oral cavity surface and the outer surface layers may comprise a mucoadhesive polymer, e.g. carboxy polymethylene, polycarbophil or polyvinyl pyrrolidone, and a film forming polymer, eg. hydroxypropylmethyl cellulose (HPMC). Suitable release modulating agents include HPMC and polyvinyl acetate. The carrier may be a toothpaste or mouthwash. 2. The composition of claim 1 , wherein said second flavor is released from said multilayer film at a rate effective to deliver said second flavor to the oral cavity after said multilayer film adheres to an oral cavity surface.3. The composition of claim 2 , wherein said multilayer film further comprises an active material.4. The composition of claim 2 , wherein the outer surface layers comprise the same materials.5. The composition of claim 2 , wherein the release modulating agent is selected from polyvinyl acetate; hydroxypropylmethyl cellulose; and hydroxyethyl cellulose and the release modulating agent is present in an amount from about 5% to about 30% by weight of the multilayer film.6. (canceled)7. The composition of claim 4 , wherein said outer surface layers and said center layer comprise a film forming polymer.8. The composition of claim 7 , wherein the film forming polymer is selected from hydroxypropylmethyl cellulose claim 7 , methyl cellulose claim 7 , hydroxypropyl cellulose and a combination of two or more thereof.9. The composition of claim 8 , wherein the release modulating agent is selected from polyvinyl acetate; hydroxypropylmethyl cellulose; ...

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Номер записи: 57
02-05-2013 дата публикации

Chemical Treatments for the Disruption of Dental Plaque Biofilms and Related Methods

Номер: US20130108560A1
Автор: Ed Maliski, Eric Allen, Robert Davidson
Принадлежит: Ed Maliski, Eric Allen, Robert Davidson

A thin film composition for oral administration that adheres to and dissolves in a mouth of a user, wherein the thin film is a single layered water-soluble solid comprising at least one D-amino acid contained in a plurality of hydrophobic carriers dispersed throughout the thin film. The hydrophobic carriers comprise oil and the composition further comprises a phospholipid, an emulsifier, and a water soluble polymer. The preferred D-amino acids are D-leucine, D-tryptophan, D-methionine, and D-tyrosine. A method of reducing dental plaque in a subject entails placing the thin film composition contemplated herein into a mouth of the subject.

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Номер записи: 58
02-05-2013 дата публикации

Antibacterial and antifungal peptides

Номер: US20130108575A1
Автор: Chris Kaplan, Daniel K. Yarbrough, Jee-Hyun Sim, Jian He, Maxwell Anderson, Randal H. Eckert
Принадлежит: C3 Jian Inc

This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.

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Номер записи: 59
02-05-2013 дата публикации

ABRASIVE CONFECTIONARY PRODUCTS

Номер: US20130108677A1
Автор: Harpaz Shimon
Принадлежит: BREEZY INDUSTRIES LTD.

There is provided a consumable abrasive confectionery product for the reduction of oral malodor and for treatment of other oral cavity conditions, comprising substantially uniformly dispersed abrasive particles configured to at least partially erode deposits in the oral cavity, wherein the abrasive quality of the confectionery product is substantially constant as the confectionery product is consumed and wherein the use of the product does not induce a gag reflex. 1. A consumable abrasive confectionery product adapted to reduce oral malodor comprising substantially uniformly dispersed abrasive particles configured to at least partially erode , scrub , loosen and/or abrade deposits in the oral cavity , wherein the abrasive quality of the confectionery product is substantially constant as the confectionery product is consumed.2. The confectionery product according to claim 1 , wherein the abrasive quality is in the range of about 10-20 gr/cm.3. The confectionery product according to claim 1 , wherein the abrasive quality is in the range of about 13-18 gr/cm.4. The confectionery product according to claim 1 , wherein the density of the particles is in the range of about 0.1-2 gr/ml.5. The confectionery product according to claim 1 , wherein the confectionery product further comprises a stick partially disposed in the confectionery product claim 1 , wherein the stick is a safety stick claim 1 , a tooth pick claim 1 , or both.6. The confectionery product according to claim 1 , wherein the oral cavity comprises tongue claim 1 , cheek claim 1 , palate claim 1 , teeth claim 1 , gum claim 1 , and combinations thereof.7. The confectionery product according to wherein the particles are structured to at least partially erode claim 6 , scrub claim 6 , loosen and/or abrade deposits on the inner grooves and/or on dorsal region of the tongue.8. The confectionery product according to claim 1 , wherein the particles are selected from granules claim 1 , capsules claim 1 , or both.9. ...

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Номер записи: 60
02-05-2013 дата публикации

HYPOCHLORITE DENTURE COMPOSITIONS AND METHODS OF USE

Номер: US20130109608A1
Автор: Rumberger Evan, Smith William L.
Принадлежит: The Clorox Company

A solid composition including calcium and/or magnesium hypochlorite, a builder (e.g., one or more of carbonate, bicarbonate, sesquicarbonate), an acid, a water-soluble polymer, at least one anionic surfactant, and optionally, a hydrotrope. The composition does not include any potassium hypochlorite, sodium hypochlorite, lithium hypochlorite, N-halogenated compounds, peroxides, persulfates, hydantoins, isocyanurates, or carboxylic acids that also have hydroxyl, amino, amido, imino, or imido groups. Upon dissolution of the composition in water, the calcium and/or magnesium hypochlorite and acid react to form hypochlorous acid. The use of hypochlorous acid, rather than direct use of an alkaline or alkaline earth hypochlorite results in a composition that is typically acidic rather than basic, and that results in improved cleaning. The composition is particularly suited tor cleaning and disinfecting dentures. 1. A solid , one-layered composition comprising:i. a hypochlorite selected from the group consisting of calcium hypochlorite, magnesium, hypochlorite and mixtures thereof;ii. a builder selected from the group consisting of carbonate, bicarbonate, sesquicarbonate and mixtures thereof;iii. at least 30% by weight of an acid selected from the group consisting of a carboxylic acid, a dicarboxylic acid, a sulfonic acid, an acid sulfate, an acid phosphate, and mixtures thereof;iv. a water-soluble polymer selected from the group consisting of a polycarboxylate, a sulfonated caxboxylate, a polysulfonate, a polyvinylpyrrolidone, a polypyridinium salt, a polyquaternary ammonium salt, and mixtures thereof; andwherein the composition does not contain potassium hypochlorite, sodium hypochlorite, lithium, hypochlorite, N-halogenated compounds, peroxides, persulfates, hydantoins, isocyanurates, carboxylic acids that also have hydroxyl, amino, amido, imino, or imido groups;wherein the composition contains only one layer.2. The composition of claim 1 , wherein the hypochlorite is ...

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Номер записи: 61
09-05-2013 дата публикации

DEBRIDEMENT PASTE

Номер: US20130115248A1
Автор: Haugen Håvard J., Lyngstadaas S. Petter
Принадлежит: CORTICALIS AS

The present invention relates to a new and inventive composition for implant cleaning and/or debridement of hard surfaces in the oral cavity, which comprises optimally activated nanoparticles of TiO, having a mean particle diameter (D) of about 10-100 nm at a concentration between 0.5-500 g/L, and HO, at a concentration of at the most 7.5% by volume, said composition being antibacterial, without causing microbial resistance, and anti-inflammatory, and wherein said composition further comprises solid microparticles, having a mean particle diameter (D) of about 100-200 μm at a concentration between 0.5-300 g/L, for improved mechanical debridement and/or cleaning of rough surfaces in the oral cavity and/or on an implant. 1. An antimicrobial and/or anti-inflammatory composition for implant cleaning and/or debridement of a hard surface in the oral cavity , which comprises{'sub': 2', '50, 'a. nanoparticles of TiO, having a mean particle diameter (D) of 10-100 nm at a concentration between 0.5-500 g/L,'}{'sub': 2', '2, 'b. HOat a concentration of at the most 7.5% by volume, and'}{'sub': '50', 'c. solid microparticles having a mean particle diameter (D) of 100-200 μm at a concentration between about 0.5-300 g/L.'}2. An antimicrobial and/or anti-inflammatory composition according to claim 1 , wherein said nanoparticles of TiOare selected from the group consisting of particles having a mean particle diameter (D) of 20-30 nm.3. An antimicrobial and/or anti-inflammatory composition according to claim 1 , wherein said nanoparticles of TiOare present at a concentration of about 10-300 g/L.4. An antimicrobial and/or anti-inflammatory composition according to claim 1 , wherein said nanoparticles of TiOare crystalline.5. An antimicrobial and/or anti-inflammatory composition according to claim 1 , wherein said solid microparticles are selected from the group consisting of particles having a mean particle diameter (D) of 120-180 μm.6. An antimicrobial and/or anti-inflammatory ...

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Номер записи: 62
16-05-2013 дата публикации

Selection and Use of Lactic Acid Bacteria for Reducing Dental Caries and Bacteria Causing Dental Caries

Номер: US20130121932A1
Автор: Connolly Eamonn, Mollstam Bo
Принадлежит:

New strains of that have been selected for their capability of improved reduction the number of in the mouth of mammals through inhibiting activity in combination with better binding to the oral mucins and dental plaque, thereby preventing, reducing or treating dental caries, and products derived from said strains, including agents for treatment or prophylaxis of caries for administration to humans. 1Lactobacillus reuteri. A biologically pure culture of strain FJ1 “Prodentis” (ATCC PTA-5289).2Lactobacillus reuteri. A biologically pure culture of strain FJ3 (ATCC PTA-5290).3LactobacillusStreptococcus mutans. A biologically pure culture of selected for its ability of reducing the number of in the mouth for prophylaxis or treatment of dental caries in mammals using a selection assay of inhibiting activity in combination with good binding to oral mucins.4Lactobacillus reuteri. A product for inhibiting the growth of dental caries bacteria , comprising cells of at least one strain of selected have inhibitory activity against cariogenic bacteria in combination with good binding to oral mucins.5Lactobacillus reuteriLactobacillus reuteri. The product according to claim 4 , wherein the at least one strain is selected from the group consisting of: strain FJ1 “Prodentis” (ATCC PTA-5289) claim 4 , and strain FJ3 (ATCC PTA-5290).6. The product according to claim 4 , wherein the product is a food product.7. The product according to claim 6 , wherein the food product is selected from the group consisting of yogurt claim 6 , jelly claim 6 , pudding claim 6 , chewing gum claim 6 , lozenge claim 6 , candy claim 6 , chocolate claim 6 , biscuit claim 6 , cookie claim 6 , cheese claim 6 , juice and tea8. The product according to claim 6 , wherein the food product is a milk-containing product.9. The product according to claim 8 , wherein the food product is yogurt.10. The product according to claim 4 , wherein the product is a dental treatment product.11. The product according to claim 10 ...

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Номер записи: 63
23-05-2013 дата публикации

ORAL CARE COMPOSITIONS

Номер: US20130129642A1
Автор: Joiner Andrew, Philpotts Carole Jane
Принадлежит:

The invention provides an oral care composition suitable for delivering a temporary whitening effect to the surface of teeth, the composition comprising: a continuous phase comprising water or polyhydric alcohol or a mixture thereof; a tooth surface whitening agent which is dispersed in the continuous phase, and a deposition aid for the tooth surface whitening agent; characterised in that the tooth surface whitening agent is a lake dye formed by fixing a dye onto a particulate inorganic substrate, in which the dye used to form the lake dye is a triarylmethane dye having a blue to green-blue colour with a hue angle in the CIELAB system ranging from 180 to 270 degrees, and in which the amount of lake dye is at least 0.015% by total weight lake dye based on the total weight of the composition. 1. An oral care composition suitable for delivering a temporary whitening effect to the surface of teeth , the composition comprising:a continuous phase comprising water or polyhydric alcohol or a mixture thereof;a tooth surface whitening agent which is dispersed in the continuous phase, anda deposition aid for the tooth surface whitening agent;characterised in that the tooth surface whitening agent is a lake dye formed by fixing a dye onto a particulate inorganic substrate, in which the dye used to form the lake dye is a triarylmethane dye having a blue to green-blue colour with a hue angle in the CIELAB system ranging from 180 to 270 degrees, and in which the amount of lake dye is at least 0.015% by total weight lake dye based on the total weight of the composition.2. An oral care composition according to claim 1 , in which the dye used to form the lake dye has a hue angle in the CIELAB system ranging from 180 to 200 degrees.3. An oral care composition according to claim 1 , in which the particulate inorganic substrate onto which the dye is fixed is hydrated alumina.4. An oral care composition according to claim 1 , in which the deposition aid is a poly(carboxylic acid) polymer ...

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Номер записи: 64
23-05-2013 дата публикации

ORAL CARE COMPOSITIONS

Номер: US20130129643A1
Автор: Boyd Thomas, Mirajkar Yelloji-Rao K., Prencipe Michael, Xu Guofeng, Yang Ying
Принадлежит: Colgate-Palmolive Company

An oral care composition for treating or preventing calculus comprising an anticalculus agent and an antibacterial agent comprising a biphenol compound obtainable from wherein the composition is free of phosphate-containing anticalculus agents. 2. The oral care composition of claim 1 , wherein the anticalculus agent consists essentially of a zinc ion source.3. The oral care composition of claim 1 , wherein the zinc ion source comprises zinc oxide.4Magnolia. The oral care composition of claim 1 , wherein the antibacterial agent is selected from magnolol claim 1 , honokiol claim 1 , tetrahydromagnolol claim 1 , tetrahydrohonokiol claim 1 , propylmagnolol claim 1 , propylhonokiol claim 1 , isopropylmagnolol claim 1 , isopropylhonokiol claim 1 , butylmagnolol claim 1 , and butylhonokiol.5Magnolia. The oral care composition of claim 1 , wherein the antibacterial agent comprises magnolol.6. The oral care composition according to claim 1 , wherein the composition further comprises sodium sulphate and sodium lauryl sulphate.7. The oral care composition according to claim 1 , wherein the composition comprises at least 1.6% by weight of sodium lauryl sulphate.8. The oral care composition according to claim 1 , wherein the oral care composition is a dentifrice.9. A method for treating or preventing calculus formation in the oral cavity claim 1 , which comprises contacting the oral cavity with the oral care composition of .10Magnolia. A method of preventing inhibition of oral uptake of a antibacterial agent from an oral care composition of comprising formulating the oral care composition without phosphate-containing anticalculus agents or polyphosphate-containing anticalculus agents. The present invention relates to oral care compositions and methods employing such compositions for use in treating or preventing calculus formation.Dental plaque is a soft deposit which forms on the surfaces of teeth. Dental plaque is generally believed to be formed as a byproduct of bacterial ...

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Номер записи: 65
30-05-2013 дата публикации

P-MENTHANE-3,8-DIOL ISOMER MIXTURE, COMPOSITION COMPRISING THE SAME, AND PRODUCTS COMPRISING THE MIXTURE OR COMPOSITION

Номер: US20130136704A1
Автор: Ishida Kenya, Komatsuki Yasuhiro, SHIROYAMA Kenichiro
Принадлежит: TAKASAGO INTERNATIONAL CORPORATION

An object of the present invention is to provide a novel technology for preventing crystal precipitation of p-menthane-3,8-diol, and stable products utilizing this technology. Provided is a p-menthane-3,8-diol isomer mixture, wherein the mass ratio of cis isomers:trans isomers in terms of the relative configuration at Positions 3 and 4 is 55:45 to 45:55. Also provided are stable products and the like containing the p-menthane-3,8-diol isomer mixture. 1. A p-menthane-3 ,8-diol isomer mixture , wherein the mass ratio of cis isomers:trans isomers in terms of the relative configuration at Positions 3 and 4 is 55:45 to 45:55.2. A composition obtained by mixing the p-menthane-3 claim 1 ,8-diol isomer mixture according to with an organic solvent.3. The composition according to claim 2 , whereinthe organic solvent is one or more selected from monoalcohols, polyols, ester oils, hydrocarbons, and silicone oils.4. The composition according to claim 2 , whereinthe mass ratio of the p-menthane-3,8-diol isomer mixture to the organic solvent is 90:10 to 30:70.5. The composition according to claim 2 , whereinthe organic solvent is a monoalcohol or polyol having 2 to 20 carbon atoms.6. An insect pest repellent composition claim 1 , comprising the p-menthane-3 claim 1 ,8-diol isomer mixture according to .7. The insect pest repellent composition according to claim 6 , further comprising at least one component selected from N claim 6 ,N-diethyl-m-toluamide claim 6 , 3-(N-n-butyl-N-acetyl)aminopropionic acid ethyl ester claim 6 , and 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinecarboxylate.8. A sensory stimulant composition claim 1 , comprising the p-menthane-3 claim 1 ,8-diol isomer mixture according to in combination with at least one component selected from menthol claim 1 , isopulegol claim 1 , menthone claim 1 , camphor claim 1 , pulegol claim 1 , cineol claim 1 , mint oil claim 1 , 3-menthoxypropane-1 claim 1 ,2-diol claim 1 , N-alkyl-p-menthane-3-carboxamide claim 1 , 3-menthoxy ...

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Номер записи: 66
06-06-2013 дата публикации

ORAL CARE PRODUCT AND METHODS OF USE AND MANUFACTURE THEREOF

Номер: US20130142736A1
Автор: Kohli Rajnish, Robinson Richard Scott, Sullivan Richard J.
Принадлежит: Colgatge-Palmolive Company

Described herein, are compositions comprising an effective amount of a basic amino acid in free or salt form, and a water soluble strontium salt; and methods of making and using the same. 1. An oral care composition comprisinga. an effective amount of a basic amino acid, in free or salt form; andb. an effective amount of a water soluble strontium salt.2. The oral care composition according to wherein the basic amino acid is arginine claim 1 , or a salt thereof.3. The oral care composition of claim 1 , wherein the water soluble strontium salt is selected from strontium acetate; strontium chloride; strontium nitrate; strontium lactate; strontium bromide; and a combination of two or more thereof.4. The oral care composition of further comprising a fluoride ion source.5. The oral care composition according to wherein the fluoride ion source is selected from sodium monofluorophosphate; stannous fluoride; sodium fluoride; potassium fluoride; sodium fluorosilicate; ammonium fluorosilicate; amine fluoride; ammonium fluoride; and a combination of two or more thereof.6. The oral care composition of in the form of a dentifrice.7. The oral care composition of in the form of a mouth rinse.8. The oral care composition of claim 1 , further comprising a potassium ion source.9. The oral care composition of claim 8 , wherein said potassium ion source is selected from potassium nitrate and potassium chloride.10. The oral care composition of claim 1 , further comprising a strontium-glass complex.11. The oral care composition of claim 10 , wherein the strontium-glass complex comprises strontium sodium phosphosilicate.13. A method for promoting systemic health comprising applying an effective amount of the oral composition of to a surface of the oral cavity of a subject in need thereof.14. An oral care composition according to claim 1 , for use in:a. reducing or inhibiting formation of dental caries,b. reducing, repairing or inhibiting early enamel lesions,c. reducing or inhibiting ...

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Номер записи: 67
13-06-2013 дата публикации

Personal care and medicinal products incorporating orgnosulfur groups

Номер: US20130149256A1
Автор: Ott David Michael
Принадлежит:

Personal care products useful for the maintenance of personal appearance and good health and minor treatments that do not require professional health care, as well as products that provide a combination of anti-microbial, anti-oxidant, anti-inflammatory, and anti-aging properties and are suitable for use without a prescription. The products utilize a biomembrane permeable organosulfur compound that can redox cycle between thiol, disulfide, and thiosulfinate forms in response to oxidants and antioxidants inside and outside of cells. Example products include an anti-microbial toothpaste with anti-plaque properties, an anti-inflammatory skin lotion with antioxidant, antimicrobial, and deodorant properties, and an anti-toxin skin lotion with anti-arsenicosis properties. 119-. (canceled)20allium. An anti-plaque oral care dentifrice composition comprising a membrane permeable related compound selected from the group consisting of allyl mercaptan , n-propyl mercaptan , diallyl disulfide , di-n-propyl disulfide. n-propyl allyl disulfide and combinations thereof , mixed with an orally acceptable carrier suitable for application to the teeth.221allium. The composition of claim where said membrane permeable related compound is allyl mercaptan.231allium. The composition of claim where said membrane permeable related compound is diallyl disulfide.24. The composition of where said diallyl disulfide is the diallyl disulfide of garlic oil.251allium. The composition of claim where said membrane permeable related compound is di-n-propyl disulfide.26. The composition of where said di-n-propyl disulfide is the di-n-propyl disulfide of onion oil.27allium. A method of making an anti-plaque oral care dentifrice composition comprising mixing a membrane permeable related compound selected from the group consisting of allyl mercaptan claim 25 , n-propyl mercaptan claim 25 , diallyl disulfide claim 25 , di-n-propyl disulfide. n-propyl allyl disulfide and combinations thereof claim 25 , with ...

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Номер записи: 68
13-06-2013 дата публикации

ANTIMICROBIAL COMPOSITIONS

Номер: US20130149257A1
Автор: Giori Andrea, Mombelli Giacomo, Togni Stefano
Принадлежит: INDENA S.P.A.

The present invention relates to the use as an antimicrobial of tamarind seed polysaccharide (TSP) and to antimicrobial compositions which contain it as active ingredient. Antimicrobial compositions containing TSP are particularly useful for topical administration in the treatment and/or prevention of microbial infections of the skin and mucosa. 1. Method of preventing or treating microbial infection comprising:administering and effecting amount of Tamarind seed polysaccharide to a patient in need thereof.2. Method according to claim 1 , wherein the infection is caused by a bacterium claim 1 , a yeast claim 1 , a virus or a fungus.3. Method according to claim 2 , wherein the infection is a bacterial infection.4. Method according to wherein said microbial infections are microbial infections of skin or mucosa.5. Method according to for topical administration.6. Method according to for treating mucositis and stomatitis.7. An antimicrobial pharmaceutical and/or dermocosmetic composition containing tamarind seed polysaccharide as active ingredient mixed with one or more acceptable excipients.8. A composition according to claim 7 , for topical administration.9. A composition according to claim 7 , in the form of cream claim 7 , ointment claim 7 , gel claim 7 , gum claim 7 , toothpaste claim 7 , mouthwash or shampoo.10. A composition according to claim 7 , comprising at least a further active ingredient selected from the group consisting of antimicrobial agents claim 7 , anti-inflammatory agents and wound-healing agents.11Helichrysum italicum, EchinaceaAesculus hippocastanum, Zanthoxylum bungeanum. A composition according to claim 7 , further comprising an extract of spp. claim 7 , or mixtures thereof.12. A composition according to claim 7 , wherein the tamarind seed polysaccharide quantity ranges from 0.1% to 5% by weight.13. (canceled)14. A method of preventing and/or treating a patient having a microbial infection comprising administering a therapeutically effective ...

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Номер записи: 69
13-06-2013 дата публикации

RAPIDLY DISSOLVING COMESTIBLE SOLID

Номер: US20130149258A1
Автор: Carroll Thomas J., Kumiega Steven M.
Принадлежит: THE HERSHEY COMPANY

A rapidly dissolving comestible solid is disclosed that includes a fondant formed from a super saturated solution having a bulk sweetener, a hydrocolloid, a texturizing agent, and water. Other ingredients may also be added, and in embodiments in which the solid is provided as a breath freshener, flavoring agents, cooling agents and/or other ingredients useful in conventional breath freshening products may be used. A method for making the comestible solid is also disclosed. 1. A rapidly dissolving comestible solid comprising a fondant formed of a bulk sweetener , a texturizing agent and , optionally , a hydrocolloid , wherein the fondant has a crystalline structure that does not exhibit cold flow at room temperature.2. The comestible solid of claim 1 , wherein the fondant is a super saturated solution that has a pre-cooking composition of about 68% to about 75% by weight bulk sweetener claim 1 , about 15% to about 25% by weight texturizing agent claim 1 , up to about 3.0% by weight hydrocolloid claim 1 , and up to about 10% by weight water.3. The comestible solid of claim 1 , further comprising flavoring agents claim 1 , sensates claim 1 , or combinations thereof.4. The comestible solid of claim 1 , wherein the comestible solid has a post-processing moisture content of about 3% to about 6% by weight.5. The comestible solid of claim 1 , wherein the comestible solid has a post-processing water activity in the range of about 0.40 to about 0.67.6. The comestible solid of claim 1 , wherein the comestible solid has a post-processing water activity in the range of about 0.50 to about 0.60.7. The comestible solid of claim 1 , wherein the bulk sweetener comprises xylitol.8. The comestible solid of claim 1 , wherein the hydrocolloid comprises a cellulose derivative.9. The comestible solid of claim 1 , wherein the texturizing agent comprises maltitol syrup.10. The comestible solid of claim 1 , wherein the bulk sweetener comprises xylitol claim 1 , the texturizing agent ...

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Номер записи: 70
13-06-2013 дата публикации

Emulsions containing saccharide siloxane copolymer emulsifiers and methods for their preparation and use

Номер: US20130149260A1
Автор: Cindy Delvalle, Cinecttina Scavuzzo, Eric Jude Joffre, Isabelle Van Reeth, Simon Toth
Принадлежит: Dow Corning Corp

An emulsion contains a saccharide siloxane copolymer as an emulsifier. The emulsion is useful in formulating personal care products.

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Номер записи: 71
13-06-2013 дата публикации

EMULSIONS CONTAINING SACCHARIDE SILOXANE COPOLYMER EMULSIFIERS AND METHODS FOR THEIR PREPARATION AND USE

Номер: US20130149261A1
Автор: Delvalle Cindy, Joffre Eric Jude, Scavuzzo Conecttina, Toth Simon, Van Reeth Isabelle
Принадлежит: Dow Corning Corporation

A saccharide siloxane copolymer is useful as an emulsifier. Emulsions prepared with the saccharide siloxane copolymer are useful in personal care products. 2. The method of claim 1 , where each subscript j is independently an integer with a value ranging from 0 to 500 and each subscript k is independently an integer with a value ranging from 0 to 500.3. The method of claim 1 , where each Rand each Rare independently an alkyl group of 1 to 12 carbon atoms.4. The method of claim 1 , where the oil is added before and/or during step i).5. The method of claim 1 , where the oil is added during and/or after step ii).6. The method of claim 1 , further comprising iv) removing the solvent.7. The method of claim 1 , where step i) is performed by reacting ingredients comprising:(A) an amino-functional polyorganosiloxane, and(B) a sugar lactone.9. The method of claim 8 , where ingredient (A) is selected from trimethylsiloxy-terminated poly(dimethylsiloxane/methyl(aminoethylaminoisobutyl)siloxane) claim 8 , trimethylsiloxy-terminated poly(dimethylsiloxane/methyl(aminopropyl)siloxane) claim 8 , trimethylsiloxy-terminated poly(dimethylsiloxane/methyl(aminoethylaminopropyl)siloxane) claim 8 , and combinations thereof.11. The method of claim 10 , where ingredient (B) is selected from butyrolactone claim 10 , epsilon caprolactone and delta gluconolactone.12. The method of claim 1 , where step i) is performed by reacting ingredients comprising:(A) an epoxy-functional polyorganosiloxane, and(B) an n-alkyl glucamine.14. The method of claim 12 , where the n-alkyl glucamine is n-methyl glucamine.15. The method of claim 12 , further comprising preparing the epoxy functional polyorganosiloxane by hydrosilylation of ingredients comprising an alkenyl functional epoxy containing compound and a polyorganohydrogensiloxane.16. The method of claim 15 , where the alkenyl functional epoxy containing compound is allyl glycidyl ether claim 15 , dodecyl glycidyl ether claim 15 , tetradecyl glycidyl ...

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Номер записи: 72
13-06-2013 дата публикации

COMPOSITIONS USEFUL FOR TOOTH WHITENING

Номер: US20130149262A1
Автор: Narasimhan Saroja, Sharma Deepak
Принадлежит: McNeil-PPC, Inc.

The present invention provides tooth whitening compositions in the form of a liquid crystal or a microemulsion that includes a tooth whitening agent in an amount effective to whiten teeth, a hydrophilic phase including water, a hydrophobic phase including at least one oil, at least one anionic, nonionic, amphoteric or zwitterionic surfactant, and a water soluble co-solvent having a Hildebrand solubility parameter above 12 (cal/cm), as well as methods for whitening teeth including applying the liquid crystal or microemulsion composition to the teeth for a period of time and under conditions effective to whiten the teeth. 2. The method according to wherein the oil has a Hildebrand solubility parameter value ranging from about 5 to about 12 (cal/cm).3. The method according to wherein the composition comprises from about 1% to about 50% of the whitening agent by weight of the composition claim 2 , and wherein the amount of hydrophilic phase ranges from about 1% to about 80% by weight of the composition claim 2 , the amount of the hydrophobic phase ranges from about 1% to less than 50% by weight of the composition claim 2 , and the hydrophilic phase is in predominant weight proportion relative to the hydrophobic phase.4. The method according to wherein the oil is selected from the group consisting of olive oil claim 3 , coconut oil claim 3 , linseed oil claim 3 , corn oil claim 3 , mineral oil claim 3 , clove oil claim 3 , isopropyl myristate and isopropyl palmitate.5. The method according to wherein the co-solvent is selected from the group consisting of monohydric alcohols claim 4 , polyhydric alcohols claim 4 , sugars and polyols.6. The method according to wherein the co-solvent is selected from the group consisting of ethanol claim 4 , propanol claim 4 , propylene glycol claim 4 , butylene glycol claim 4 , ethylene glycol claim 4 , glycerine claim 4 , glucose claim 4 , fructose claim 4 , mannose claim 4 , mannitol claim 4 , malitol claim 4 , lactitol and inositol.7. ...

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Номер записи: 73
27-06-2013 дата публикации

FUSION PEPTIDES COMPRISING MULTI-FUNCTIONAL PEPTIDIC SOLUBILITY TAGS FOR EFFICIENT PRODUCTION, PROCESSING AND SURFACE APPLICATIONS

Номер: US20130164353A1
Автор: Fahnestock Stephen R., FOSSER KARI A., GRUBER TANJA MARIA, ROUVIERE PIERRE E.
Принадлежит: E I DU PONT DE NEMOURS AND COMPANY

Compositions and methods using fusion peptides comprising multi-functional solubility tags are provided. The multi-functional peptidic solubility tags facilitates more efficient fusion peptide production, easier downstream processing of the fusion peptide, and may be used to provide functional surface properties when coupled to a target material. 2. The method of wherein at least one condition from said first set of conditions is altered to promote or enhance deposition of the soluble fusion peptide to the surface of said first target material in contacting step (e).3. The method of wherein said at least one condition is altered prior to claim 2 , or concomitantly with claim 2 , contacting step (e).4. The method of wherein the at least one condition is altered during or after contacting step (e) to promote or enhance deposition of the soluble fusion peptide on the surface of the first target material.5. The method of wherein the at least one condition that is altered is a change in pH claim 2 , a change in salt composition claim 2 , a change in salt concentration claim 2 , a change in temperature claim 2 , an addition of an insolubilization agent claim 2 , an addition of a denaturing agent claim 2 , an addition of an oxidizing agent claim 2 , an increase in fusion peptide concentration claim 2 , and any combination thereof.6. The method of wherein pH is increased.7. The method of wherein pH is decreased.8. The method of wherein pH is altered by at least one pH unit.9. The method of wherein the aqueous medium in step (d) comprises a suitable pH whereby the insoluble fusion peptide becomes soluble.10. The method of wherein the aqueous medium comprises a higher pH relative to the pH wherein the fusion peptide is insoluble.11. The method of wherein the aqueous medium comprises a lower pH relative to a pH wherein the fusion peptide is insoluble.12. The method of or wherein the second portion of the fusion peptide is characterized by a binding functionality claim 9 , an ...

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Номер записи: 74
27-06-2013 дата публикации

COMPOSITE PARTICLE ACTIVE AND METHOD FOR MAKING THE SAME

Номер: US20130164359A1
Автор: Deng Yan, Ding Guanjun, Li Xiaoke
Принадлежит:

Composite particle actives suitable for use in oral care compositions are described. The composite particle actives have a core and a coating whereby the coating interacts with phosphate ions to produce calcium and phosphate reaction products that are suitable to adhere to tooth enamel and/or dentin in order to improve characteristics of teeth. 1. A composite particle active comprising:a) a first component core for improving an oral care characteristic; andb) a second component coating that interacts with phosphate ions to produce a calcium phosphate in situ reaction product that adheres to tooth enamel, dentin or both and that is a precursor for hydroxyapatite formation.2. The composite particle active according to wherein the first component core comprises silica claim 1 , titanium dioxide claim 1 , zinc oxide claim 1 , mica claim 1 , calcium carbonate claim 1 , barium sulfate claim 1 , or a mixture thereof claim 1 , and the second component coating comprises elemental calcium claim 1 , and optionally claim 1 , potassium claim 1 , sodium claim 1 , aluminum claim 1 , magnesium or a mixture thereof.3. The composite particle active according to or wherein at least 5% of the first component core is coated with second component coating.4. The composite particle active according to any of the preceding claims wherein the composite particle active has a diameter of less than 50 microns.5. The composite particle active according to any of the preceding claims wherein the core of the composite particle active makes up from 3 to 98% by weight of the composite particle active.6. The composite particle active according to any of to wherein the first component core comprises at least 50% by weight titanium dioxide and the second component coating comprises at least 50% by weight calcium element.7. The composite particle active according to any of the preceding claims wherein the second component coating comprises calcium phosphate claim 1 , calcium gluconate claim 1 , calcium ...

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Номер записи: 75
04-07-2013 дата публикации

Oral care compositions for benefiting teeth

Номер: US20130171221A1
Автор: Guanjun Ding, Xiaoke Li, Yan Deng
Принадлежит: Conopco Inc

Oral care compositions with composite particle actives are described. The composite particle actives have a core and a coating whereby the coating interacts with phosphate ions to produce calcium and phosphate reaction products that are suitable to adhere to tooth enamel and/or dentin in order to improve the characteristics of teeth.

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Номер записи: 76
18-07-2013 дата публикации

COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND METHODS OF MAKING SAME

Номер: US20130183252A1
Автор: Arellano Melissa, Brady Thomas, Brust Paul, Ching Brett Weylan, Darmohusodo Vincent, Karanewsky Donald S., Li Qing, Li Xiaodong, Ling Jing, Patron Andrew, Priest Chad, Pronin Alexey, Selchau Victor, Servant Guy, Tachdjian Catherine, Xu Hong, Zhang Lan, Zhao Wen
Принадлежит: Senomyx, Inc.

The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals. 2. The compound of claim 1 , wherein X is selected from the group consisting of hydrogen claim 1 , heteroalkyl claim 1 , substituted heteroalkyl claim 1 , heteroaryl claim 1 , substituted heteroaryl claim 1 , heteroarylalkyl claim 1 , substituted heteroarylalkyl claim 1 , CN claim 1 , S(O)R claim 1 , CONRR claim 1 , —COR claim 1 , SONRR claim 1 , NRSOR claim 1 , NRSONRR claim 1 , B(OR)(OR) claim 1 , P(O)(OR)(OR) claim 1 , and P(O)(R)(OR).7. A composition comprising one or more compounds of claim 1 , or a salt claim 1 , hydrate claim 1 , solvate or N oxide thereof claim 1 , and one or more pharmaceutically acceptable carriers.8. The composition of claim 7 , which is a food claim 7 , beverage or medicament for human consumption.9. A coffee or coffee flavored food or beverage or medicament composition that comprises at least one compound of or a salt claim 1 , hydrate claim 1 , solvate or N oxide thereof.10. The composition of claim 9 , which is an instant coffee claim 9 , ground coffee claim 9 , or brewed coffee.11. The composition of claim 9 , which is an instant coffee.12. A food claim 1 , beverage claim 1 , or medicament composition having a bitter taste wherein said bitter taste is alleviated or eliminated by the addition of an effective amount of a compound of or a salt claim 1 , hydrate claim 1 , ...

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Номер записи: 77
18-07-2013 дата публикации

Dual Component Oral Composition For Enhancing Remineralization of Teeth

Номер: US20130183253A1
Автор: Kimberlee U. Martin, Thomas Ray O'Brien
Принадлежит: Individual

An dual oral composition is provided having a first peroxide-containing component and a second bicarbonate-containing component having exceptional anti-plaque and anti-bacterial action with re-mineralization properties.

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Номер записи: 78
25-07-2013 дата публикации

Acrylate Copolymer Thickeners

Номер: US20130189198A1
Автор: Tamareselvy Krishnan
Принадлежит: LUBRIZOL ADVANCED MATERIALS, INC.

Disclosed are surfactant compositions containing at least one crosslinked acrylic copolymer. The crosslinked acrylic copolymer is polymerized in the presence of at least two different classes of crosslinking monomers. The crosslinked acrylic copolymers provide desirable rheological, clarity, and aesthetic properties in aqueous surfactant containing compositions. 1. A surfactant composition comprising:i) at least one surfactant selected from anionic, zwitterionic or amphoteric, cationic, or non-ionic surfactant, and combinations thereof;ii) a crosslinked acrylic copolymer polymerized from a monomer composition comprising:a) from about 10% to about 80% by weight of a first monomeric component selected from one or more ethylenically mono-unsaturated monomers containing at least one carboxylic acid group;{'sub': 1', '5', '1', '5, 'b) from about 90% to about 15% by weight of a second ethylenically mono-unsaturated monomeric component selected from at least one linear or branched Cto Calkyl ester of (meth)acrylic acid, at least one Cto Chydroxyalkyl ester of (meth)acrylic acid, and mixtures thereof;'}c) from about 0.01% to about 5% by weight of crosslinking component selected from a first polyunsaturated crosslinking monomer and a second polyunsaturated crosslinking monomer, wherein said first crosslinking monomer is selected from at least one polyfunctional acrylate having at least two polymerizable ethylenically unsaturated double bonds and said second crosslinking monomer is selected from at least one polyalkenyl polyether having at least two polymerizable ethylenically unsaturated double bonds; and optionallyd) from about 1% to about 35% by weight of at least one other ethylenically mono-unsaturated monomer component different from monomeric components a) and b), wherein all monomer weight percentages are based on the weight of the total monomer composition.2. A surfactant composition of claim 1 , wherein said first crosslinking monomer is selected from the ...

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Номер записи: 79
25-07-2013 дата публикации

ANTIMICROBIAL DENTAL CARE PREPARATION

Номер: US20130189199A1
Автор: Geistlich Peter, Pfirrmann Rolf W.
Принадлежит: Geistlich Pharma AG

A dental care preparation in a form of a toothpaste or tooth gel dentifrice includes an antimicrobial amount of at least one antimicrobial N-methylol transfer agent, and at least one of a fluoride compound or a source of fluoride ions. 1. A dental care preparation in a form of a toothpaste or tooth gel dentifrice comprising an antimicrobial amount of at least one antimicrobial N-methylol transfer agent , and at least one of a fluoride compound or a source of fluoride ions.2. The dental care preparation of claim 1 , wherein at least a portion of said N-methylol transfer agent is dissolved in said preparation.3. The dental care preparation of claim 1 , wherein at least a portion of said N-methylol transfer agent is dispersed in said preparation as at least one of a microcrystalline claim 1 , a crystalline claim 1 , or a powder form.4. The dental care preparation of claim 2 , wherein at least a portion of said N-methylol transfer agent is further dispersed in said preparation as at least one of a microcrystalline claim 2 , a crystalline claim 2 , or a powder form.5. The dental care preparation of claim 1 , wherein said N-methylol transfer agent is taurolidine claim 1 , taurultam claim 1 , 1183B (cyclo-taurolidine) claim 1 , N-methylol taurinamide claim 1 , an N-methylol-containing and N-methylol transferring derivative thereof claim 1 , or any combination thereof.6. The dental care preparation of wherein said N-methylol transfer agent is taurolidine claim 1 , taurultam or a mixture thereof.7. The dental care preparation of wherein at least a portion of said agent is in microcrystalline claim 1 , crystalline or powder form.8. The dental care preparation of wherein the microcrystalline claim 7 , crystalline or powder form agent functions as an abrasive in said preparation.9. The dental care preparation of claim 1 , comprising about 0.01-10% by weight said N/methylol transfer agent.10. The dental care preparation of claim 1 , comprising about 0.1-5% by weight said N/ ...

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Номер записи: 80
25-07-2013 дата публикации

MULTI-PURPOSED DENTIFRICE

Номер: US20130189201A1
Автор: Buelo Adonis, Cirigliano Anthony, Major Elizabeth, XU Yun
Принадлежит: CHURCH & DWIGHT CO., INC.

The present invention is directed towards anhydrous, single-part multi-purposed dentifrice and methods for removing plague, whitening and remineralizing teeth. 1. A substantially anhydrous single-part dentifrice comprising:a) re-mineralization component comprising a calcium salt, a phosphate salt, or a calcium phosphate salt;b) a teeth whitening component comprising an oxygen generating compound;c) at least one alkaline metal bicarbonate; andd) a substantially anhydrous and orally acceptable carrier.2. The dentifrice of claim 1 , containing up to about 50 wt. % alkaline metal bicarbonate.3. The dentifrice of claim 1 , wherein the substantially anhydrous carrier comprises a liquid humectant comprising an ethylene oxide/propylene oxide block copolymer.5. The dentifrice of claim 1 , wherein said calcium salt comprises calcium sulfate.6. The dentifrice of claim 1 , wherein said oxygen generating compound comprises peroxides claim 1 , metal chlorites claim 1 , persulfates and combinations thereof.7. The dentifrice of claim 6 , wherein said peroxides comprise alkali metal percarbonates.8. The dentifrice of claim 1 , further including at least one surfactant.9. The dentifrice of claim 4 , further including a flavoring agent.10. The dentifrice of claim 1 , in the form of a toothpaste or gel. This application is related to U.S. Provisional Patent Application Ser. No. 61/389,400 filed Oct. 4, 2010 and takes priority therefrom.The present invention relates to multi-purposed dentifrice products.Dental caries, i.e., tooth decay, is a leading cause of tooth damage in humans. Dental caries begins with lesions of so-called “white spots”, which are demineralized areas below the surface of intact dental enamel. Such subsurface lesions are formed before a cavity is detectable. If unchecked, surface enamel above a subsurface lesion eventually collapses, leading to cavitations and subsequent loss of tooth structure.The primary component of the enamel and dentin in teeth is calcium ...

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Номер записи: 81
25-07-2013 дата публикации

Oral composition

Номер: US20130189202A1
Автор: Takanori Tsugane, Yoki Saeki
Принадлежит: Individual

In the conventional methods for suppressing dental caries using antibacterial agents, enzyme inhibitors or antibiotics, exocellular polysaccharides in oral biofilm prevent the permeation of antibacterial agents, enzyme inhibitors, antibiotics, or the like, and it is thus difficult to render intended suppressive effects on dental caries. Further, use of antibacterial agents or the like involves a high risk of resistant bacteria emergence, and thus it is not preferable. Thus, there remains a need for the development of a safer and more effective method for suppressing dental caries by regulating biofilm formation caused by dental caries causative bacteria instead of controlling the dental caries causative bacteria. A composition which regulates a quorum sensing according to the present invention can provide the inhibition of the tooth decay biofilm formation.

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Номер записи: 82
25-07-2013 дата публикации

DENTINAL TUBULE SEALANT AND METHOD FOR PRODUCING THE SAME

Номер: US20130189337A1
Автор: HASHIMOTO Tadashi, ISHIHARA Shumei, Oshita Mizuko
Принадлежит: KURARAY NORITAKE DENTAL INC.

A dentinal tubule sealant comprises poorly-soluble calcium phosphate particles (A), a phosphorus-free calcium compound (B), and water (C), wherein the particles (A) are at least one member selected from the group consisting of dicalcium phosphate anhydrous [CaHPO] particles, α-tricalcium phosphate [α-Ca(PO)] particles, β-tricalcium phosphate [β-Ca(PO)] particles, amorphous calcium phosphate [Ca(PO).nHO] particles, calcium pyrophosphate [CaPO] particles, calcium pyrophosphate dihydrate [CaPO.2HO] particles, octacalcium phosphate pentahydrate [CaH(PO).5HO] particles, and dicalcium phosphate dihydrate [CaHPO.2HO] particles, and the dentinal tubule sealant contains 30 to 76% by weight of the particles (A), 0.001 to 4% by weight of the compound (B), and 23 to 69% by weight of the water (C). Thus, there is provided a dentinal tubule sealant capable of sealing dentinal tubules of an exposed dentin and also remineralizing the surrounding dentin after the sealing. 1. A dentinal tubule sealant , comprising:from 30 to 76% by weight of poorly-soluble calcium phosphate particles;from 0.001 to 4% by weight of a phosphorus-free calcium compound; andfrom 23 to 69% of water,{'sub': 4', '3', '4', '2', '3', '4', '2', '3', '4', '2', '2', '2', '2', '7', '2', '2', '7', '2', '8', '2', '4', '6', '2', '4', '2, 'wherein the poorly-soluble calcium phosphate particles are at least one member selected from the group consisting of a dicalcium phosphate anhydrous [CaHPO] particle, an α-tricalcium phosphate [α-Ca(PO)] particle, a β-tricalcium phosphate [β-Ca(PO)] particle, an amorphous calcium phosphate [Ca(PO).nHO] particle, a calcium pyrophosphate [CaPO] particle, a calcium pyrophosphate dihydrate [CaPO.2HO] particle, an octacalcium phosphate pentahydrate [CaH(PO).5HO] particle, and a dicalcium phosphate dihydrate [CaHPO.2HO] particle.'}2. The dentinal tubule sealant according to claim 1 ,{'sub': 2', '2', '3', '2', '2', '3', '2', '2', '2', '6', '10', '6', '3', '6', '5', '7', '2', '2', '3', '2', ...

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Номер записи: 83
01-08-2013 дата публикации

COLOR CHANGE OF CHALCONE-CONTAINING ORAL CARE FORMULATIONS

Номер: US20130195772A1
Автор: Du-Thumm Laurence, Schaeffer-Korbylo Lyndsay, Szewczyk Gregory
Принадлежит: Colgate-Palmolive Company

Oral care compositions and methods are described in which the composition includes a chalcone color change component, which may be phenyl-3-methoxy-4-hydroxystyryl ketone. The color change component is induced to change colors by addition of saliva and/or by a change in pH of the composition. The composition and methods provide benefits including providing visual cues to the user. 1. An oral care composition comprising a chalcone color change component that is able to change color by addition of saliva and/or by a change in pH of the composition.2. The oral care composition of claim 1 , wherein the color change component comprises phenyl-3-methoxy-4-hydroxystyryl ketone (CHAK4).3. The oral care composition of claim 1 , wherein the oral care composition is a mouthwash.4. The oral care composition of claim 2 , wherein the CHAK4 is present in an amount from 0.01% to 10% by weight of the composition.5. The oral care composition of claim 4 , wherein the CHAK4 is present in an amount from 0.01% to 0.05%.6. The oral care composition of claim 1 , wherein the pH of the composition is in the range of from 2 to 12.7. The oral care composition of claim 6 , wherein the pH of the composition is in the range of from 3.5 to 5.8. A mouthwash comprising a phenyl-3-methoxy-4-hydroxystyryl ketone in an amount from 0.01% to 10% by weight of the mouthwash.9. A method of making an oral care composition comprising a color change component comprising adding phenyl-3-methoxy-4-hydroxystyryl ketone (CHAK4) to an orally acceptable carrier.10. The method of claim 9 , wherein the CHAK4 is added in an amount from 0.01% to 10% by weight of the composition.11. The method of claim 9 , further comprising adjusting the pH to be within the range of from 3.5 to 5.0.12. A method of providing oral health benefits to an oral surface comprising contacting the oral surface according to with the oral care composition. This application claims priority to U.S. Provisional Patent Application No. 61/293,079, ...

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Номер записи: 84
01-08-2013 дата публикации

COMPOSITIONS

Номер: US20130195773A1
Автор: Kindel Günter, Krammer Gerhard, Siegel Sven
Принадлежит: SYMRISE AG

Compositions, comprising menthofuran and selected menthol compounds which feature improved flavour and odour properties, are provided and, in addition, the production of compositions, specifically, of emulsions with an improved storage stability. 2. The composition of claim 1 , additionally comprising claim 1 , as component (b) menthol compounds selected from the group consisting of menthol methyl ether claim 1 , menthone glyceryl acetal (FEMA GRAS 3807) claim 1 , menthone glyceryl ketal (FEMA GRAS 3808) claim 1 , menthyl lactate (FEMA GRAS 3748) claim 1 , menthol ethylene glycol carbonate (FEMA GRAS 3805) claim 1 , menthol propylene glycol carbonate (FEMA GRAS 3806) claim 1 , menthyl-N-ethyloxamat claim 1 , monomethyl succinate (FEMA GRAS 3810) claim 1 , monomenthyl glutamate (FEMA GRAS 4006) claim 1 , menthoxy-1 claim 1 ,2-propanediol (FEMA GRAS 3784) claim 1 , menthoxy-2-methyl-1 claim 1 ,2-propandiol (FEMA GRAS 3849) and the menthan carboxylic acid esters and amides WS-3 claim 1 , WS-4 claim 1 , WS-5 claim 1 , WS-12 claim 1 , WS-14 and WS-30 and the mixtures thereof.3. The composition of claim 1 , additionally comprising a cosmetic additive (component c) claim 1 , which is selected from the group consisting of surfactants claim 1 , oil bodies claim 1 , emulsifiers claim 1 , pearlizing waxes claim 1 , consistency factors claim 1 , thickeners claim 1 , superfatting agents claim 1 , stabilizers claim 1 , polymers claim 1 , silicon compounds claim 1 , fats claim 1 , waxes claim 1 , lecithins claim 1 , phospholipids claim 1 , UV protection factors claim 1 , moisturizers claim 1 , biogenic agents claim 1 , antioxidants claim 1 , deodorants claim 1 , antiperspirants claim 1 , anti-dandruff agents claim 1 , film formers claim 1 , swelling agents claim 1 , insect repellants claim 1 , self-tanning agents claim 1 , tyrosine inhibitors (depigmenting agents) claim 1 , hydrotropes claim 1 , solubilizers claim 1 , preservatives claim 1 , perfume oils and dyes and the mixtures ...

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Номер записи: 85
01-08-2013 дата публикации

Processes Of Making Oral Compositions Containing Gel Networks

Номер: US20130195774A1
Автор: Deckner George Endel, Leblanc Michael Jude
Принадлежит: The Procter & Gamble Company

The present invention is directed towards a process for making oral compositions comprising gel networks. The gel networks are formed from a fatty amphiphile dispersion and swelling surfactant. The fatty amphiphile dispersion comprises one or more fatty amphiphiles, one or more dispersing surfactants, and one or more solvents. A gel network is formed when the fatty amphiphile dispersion is combined with the swelling surfactant. A method of preparing the fatty amphiphile dispersion and oral composition is included. 1. A process for preparing a dentifrice composition comprising: i) one or more fatty amphiphiles selected from the group consisting of cetyl alcohol and stearyl alcohol and combinations thereof;', 'ii) one or more dispersing surfactants selected from the group consisting of cetyl hydroxyl ethyl cellulose, inulin laryl carbamide, buylated polyvinylpyrrolidone, and combination thereof;', 'iii) one or more solvents; and', 'iv) optionally, a suppressing material,', 'by heating and mixing the fatty amphiphile dispersion,, 'a) preparing a fatty amphiphile dispersion comprisingb) providing one or more swelling surfactants; andc) providing oral carrier materials,d) mixing said fatty amphiphile dispersion, swelling surfactants, and oral carrier materials to form a gel network in the dentifrice.2. The process for preparing a dentifrice composition according to whereini) the one or more fatty amphiphiles is present in an amount of from about 15% to about 60% by weight of the fatty amphiphile dispersion;ii) the one or more dispersing surfactants is present in an amount of from about 0.05% to about 5% by weight of the fatty amphiphile dispersion;iii) the one or more solvents is present in an amount of from about 35% to about 80% by weight of the fatty amphiphile dispersion; andiv) the suppressing material is present in an amount of from about 0% to about 10% by weight of the fatty amphiphile dispersion.3. A process for preparing an oral composition comprising the steps ...

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Номер записи: 86
01-08-2013 дата публикации

ABRASIVE SYSTEM FOR ORAL CARE COMPOSITIONS

Номер: US20130195942A1
Автор: Ibrahim Sayed, Prencipe Michael
Принадлежит: Colgate-Palmolive Company

Oral compositions comprising a first and a second abrasive are provided. The first abrasive preferably has an Einlehner hardness of greater than about 5 mg loss per 100,000 revolutions, and the second abrasive preferably has an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. A ratio of the first abrasive to the second abrasive ranges from about 1:1.6 to about 1.6:1, and the first and second abrasives are preferably present in the oral composition at an amount of about 13% to about 21% by weight, respectively. The pellicle cleaning ratio of the oral composition is greater than 100 and the radioactive dentin abrasiveness is preferably less than 200, and in certain embodiments, preferably less than about 175. Methods of using the oral compositions are also provided. 2. The composition according to claim 1 , wherein the radioactive dentin abrasion is less than about 175.3. The composition according to claim 1 , wherein the first abrasive has an oil of absorption of less than about 90 cm/100 g and the second abrasive has an oil of absorption of greater than about 90 cm/100 g.4. The composition according to claim 1 , wherein the first abrasive has a mean particle size of less than about 11 μm and the second abrasive has a mean particle size of greater than about 8 μm.5. The composition according to claim 1 , wherein the ratio of the first abrasive to the second abrasive is about 1:1.6. The composition according to claim 5 , wherein the first abrasive is present in an amount of about 17% by weight and the second abrasive is present in an amount of about 17% by weight in the oral composition.7. The composition according to claim 1 , wherein a total amount of the first and second abrasives in the oral composition is greater than about 30% by weight of the composition.8. The composition according to claim 1 , wherein the first abrasive is present in an amount of about 13% to about 21% by weight and the second abrasive is present in an amount of about ...

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Номер записи: 87
08-08-2013 дата публикации

ORAL CARE COMPOSITIONS

Номер: US20130202539A1
Автор: "DAgostino Eleanor Margaret", Hedges Nicholas David, Nandi Asish, Petkov Jordan Todorov
Принадлежит:

The invention provides an oral care composition obtainable by: (i) preparing an oil-in-water emulsion by dispersing an oil phase into an aqueous continuous phase, the aqueous continuous phase comprising an oil-in-water emulsifier which is selected from one or more hydrophobins, so that emulsified particles of oil phase are formed which are emulsified with the one or more hydrophobins; and (ii) combining the emulsion so obtained with an oral care base formulation which is suitable for treating the surfaces of the oral cavity. Compositions of the invention demonstrate enhanced deposition of oil phase components onto oral cavity surfaces such as tooth enamel and tooth dentine, and in particular onto damaged surfaces such as scratched and demineralised enamel. 1. An oral care composition obtainable by:(i) preparing an oil-in-water emulsion by dispersing an oil phase into an aqueous continuous phase, the aqueous continuous phase comprising an oil-in-water emulsifier which is selected from one or more hydrophobins, so that emulsified particles of oil phase are formed which are emulsified with the one or more hydrophobins; andii) combining the emulsion so obtained with an oral care base formulation which is suitable for treating the surfaces of the oral cavity.2. An oral care composition according to claim 1 , where the hydrophobin is a Class II hydrophobin.3. An oral care composition according to claim 2 , where the Class II hydrophobin is HFBI claim 2 , HFBII claim 2 , or a mixture thereof.4. An oral care composition according to claim 1 , in which the oil phase comprises (i) a mixture of medium chain saturated fatty acids ranging from caproic to lauric (Cto C) claim 1 , in their triglyceride form claim 1 , and (ii) one or more long chain unsaturated fatty acid (Cto C) monoglycerides.5. An oral care composition according to claim 1 , in which the aqueous continuous phase (into which the oil phase is dispersed) comprises less than 0.01% anionic surfactant (by total weight ...

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Номер записи: 88
15-08-2013 дата публикации

ORAL CARE COMPOSITION COMPRISING DISSOLVED TIN AND FLUORIDE

Номер: US20130209375A1
Автор: Matur Turan, Moya Argilagos Dally, Scheffel Cornelia
Принадлежит: GABA INTERNATIONAL HOLDING AG

An oral care composition comprising a liquid phase containing 30% to 90%, preferably 30% to 80% by weight, based on the liquid phase, of water; dissolved tin; 200 to 2000 ppm fluoride ions, based on the oral composition; and 5 to 60% by weight, based on the oral care composition, of a Csugar alcohol; characterised in that the content of dissolved tin [Sn] in the liquid phase is at least 750 ppm, preferably at least 1000 ppm, based on the composition; that 60 mol % or more, preferably 75 mol % or more of the content of dissolved tin [Sn] is in the formal oxidation state +II; and that the composition comprises an organic acid and ammonium cations of the Formula (I): R—NHR—[(CH)—NH+R]—R(I), wherein R is a saturated or unsaturated straight-chain hydrocarbon residue of 10 to 20 carbon atoms, v is an integer from 0 to 1, u is an integer from 2 to 3 and R, Rand Rare independently selected from hydrogen and —CHCHOH. The composition is preferably a mouthrinse. These compositions are tested in the treatment or prevention of erosive tooth demineralisation caused by food acids. 1. An oral care composition comprisinga liquid phase containing 30% to 90%, by weight, based on the liquid phase, of water;dissolved tin;200 to 2000 ppm fluoride ions, based on the oral composition; and{'sub': '(3-5)', '5 to 60% by weight, based on the oral care composition, of a Csugar alcohol;'}wherein the content of dissolved tin [Sn] in the liquid phase is at least 750 ppm, based on the composition;wherein 60 mol % or more, of the content of dissolved tin [Sn] is in the formal oxidation state +II; and {'br': None, 'sub': a', 'a', '2', 'u', 'b', 'v', 'c, 'sup': '+', 'R—NH+R—R[(CH)—NHR]R—R\u2003\u2003(I)'}, 'wherein the composition comprises an organic acid and ammonium cations of the formula (I){'sub': a', 'b', 'c', '2', '2, 'wherein R is a saturated or unsaturated straight-chain hydrocarbon residue of 10 to 20 carbon atoms, v is an integer from 0 to 1, u is an integer from 2 to 3 and R, Rand Rare ...

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Номер записи: 89
15-08-2013 дата публикации

Oral care compositions

Номер: US20130209376A1
Автор: Robert J. Corring, William E. Prosise
Принадлежит: IPS Investments Inc

Oral care compositions containing an oral care ingredient and a thickening agent, wherein the thickening agent comprises a strongly swellable, lightly to moderately crosslinked polyvinyl pyrrolidone. The polyvinyl pyrrolidone thickening agent is characterized by an aqueous gel volume of about 15 to 150 ml/g and a Brookfield viscosity of at least 10,000 cps for a 5% aqueous solution at 25° C.

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Номер записи: 90
15-08-2013 дата публикации

APPLICATIONS OF PARTIALLY AND FULLY SULFATED HYALURONAN

Номер: US20130209531A1
Автор: KENNEDY Thomas P., Oottamasathien Siam, Prestwich Glenn D.
Принадлежит: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Described herein is the use of partially and fully sulfated hyaluronan or the pharmaceutically acceptable salt or ester thereof for therapeutic and cosmetic applications as well as the treatment of a number of systemic, dermatological, periodontal, ophthalmic, and urological inflammatory diseases. 1. A method for reducing or preventing inflammation in a subject comprising administering to the subject an effective amount of a partially or fully sulfated hyaluronan or the pharmaceutically acceptable salt or ester thereof , or a combination thereof.2. The method of claim 1 , wherein at least one primary C-6 hydroxyl proton of the N-acetyl-glucosamine residue is substituted with a sulfate group.3. The method of claim 1 , wherein at least 1% of the primary C-6 hydroxyl protons of the N-acetyl-glucosamine residue of hyaluronan are substituted with a sulfate group.4. The method of claim 1 , wherein from 1% to 100% of the primary C-6 hydroxyl protons of the N-acetyl-glucosamine residue of hyaluronan are substituted with a sulfate group.5. The method of claim 1 , wherein at least one C-2 hydroxyl proton or C-3 hydroxyl proton of a uronic acid residue or at least one C-4 hydroxyl proton of an N-acetyl-glucosamine residue is substituted with a sulfate group.6. The method of claim 1 , wherein at least one C-2 hydroxyl proton and C-3 hydroxyl proton of a uronic acid residue and at least one C-4 hydroxyl proton of an N-acetyl-glucosamine residue is substituted with a sulfate group.7. The method of claim 1 , wherein the compound has a degree of sulfation from 0.1 to 4.0 per disaccharide unit.8. The method of claim 1 , wherein the partially or fully sulfated hyaluronan has an average molecular size of less than 10 kDa.9. The method of claim 1 , wherein the partially or fully sulfated hyaluronan has an average molecular size from 0.5 kDa to 10 kDa.10. The method of claim 1 , wherein the hyaluronan is not derived from an animal source.11. The method of claim 1 , wherein the ...

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Номер записи: 91
22-08-2013 дата публикации

Dentifrice Composition with Reduced Astringency

Номер: US20130216485A1
Автор: Campbell Thomas S., Fisher Steven W., Prencipe Michael
Принадлежит: Colgate-Palmolive Company

A dentifrice composition containing, in combination, an orally acceptable vehicle; a halogenated diphenyl ether; a soluble zinc salt; and a chelating agent to reduce astringency. 1. A dentifrice composition comprising:a. an orally acceptable vehicle;b. a halogenated diphenyl ether;c. a soluble zinc salt; andd. a chelating agent, wherein the chelating agent is at least one chelating agent chosen from polyvinyl phosphonates, and phytates, wherein the chelating agent is present in an amount up to 1% based on the weight of the composition.218-. (canceled)19. The composition of claim 1 , wherein the chelating agent comprises dodecasodium phytate or sodium phytate.20. The composition of claim 19 , wherein the soluble zinc salt is present in an amount of 0.5 to 2.5 wt % based on the weight of the composition.2120. The composition of claim 19 , wherein the soluble zinc salt comprises at least one zinc salt chosen from zinc citrate claim 19 , zinc acetate claim 19 , zinc lactate claim 19 , zinc chloride claim 19 , and zinc gluconate.2221. The composition of claim 19 , wherein the soluble zinc salt comprises zinc citrate.23. The composition of claim 21 , whereinthe chelating agent is present in an amount of 0.1 to 1 wt % based on the weight of the composition.24. The composition of claim 23 , wherein the halogenated diphenyl ether is triclosan.25. The composition of claim 24 , wherein the dentifrice composition further comprises stannous fluoride and a methyl vinyl ether/maleic anhydride copolymer having a molecular weight ranging from 30 claim 24 ,000 to 1 claim 24 ,000 claim 24 ,000 g/mole.26. A method for the treatment and prevention of bacterial plaque accumulation comprising: administering to the oral cavity a dentifrice composition according to . Zinc ions are known to be effective anti-microbial agents. These ions provide anti-gingivitis and anti-plaque benefits and may also improve breath and reduce sensitivity. In particular, zinc has been shown to have anti-plaque, ...

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Номер записи: 92
22-08-2013 дата публикации

SYNTHESIS OF CYCLOHEXANE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS

Номер: US20130216486A1
Автор: Bunke Gregory Mark, Haught John Christian, Yelm Kenneth Edward
Принадлежит: The Procter & Gamble Company

The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect. Preparation schemes for neoisomers of other menthyl derivatives which are useful as coolants, including esters, ethers, carboxy esters and other N-substituted carboxamides are also provided. 2. The process of wherein the reaction is conducted in the presence of potassium phosphate and the copper catalyst is a copper halide.3. The process of wherein the copper halide is copper (I) iodide.4. The process of wherein the primary menthane carboxamide is prepared by reacting a menthane acid chloride with ammonia under aqueous conditions.5. The process of wherein the menthane carboxamide is prepared by hydrolysis of a corresponding menthane nitrile.6. The process of wherein the stereochemistry of the starting menthane carboxamide is maintained through the coupling reaction with aryl halide to produce the N-substituted menthane carboxamide.7. The process of wherein (1S claim 6 ,2S claim 6 ,5R)-menthane carboxamide is reacted with aryl halide to produce neoisomers having 1S claim 6 ,2S claim 6 ,5R configuration of N-aryl substituted menthane carboxamide.8. A process for ...

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Номер записи: 93
22-08-2013 дата публикации

Induction of a physiological dispersion response in bacterial cells in a biofilm

Номер: US20130216637A1
Автор: David G. Davies
Принадлежит: Research Foundation of State University of New York

The present invention is directed to a compound which induces a physiological dispersion response in bacterial cells in a biofilm. The present invention is also directed to compositions containing this compound, methods of isolating the compound, and uses thereof.

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Номер записи: 94
29-08-2013 дата публикации

Liquid non-stick toothpaste

Номер: US20130224124A1
Автор: Douglas Bonnie Carol
Принадлежит:

My tooth cream will not stick, this is what makes it different from other tooth pastes. It can be dispensed in any type container, but it is different in that this toothpaste contains NO thickeners, no carrageenan, no cellulose gum, no glycerin and no SLS (sodium lanyl sulfates). My tooth créme can contain colorings, flavorings, preservatives, xylitol, sweetenings, fluoride . . . infinity. 1. A toothpaste (cream, wash, etc.) that is non-stick, will not stick to any surface, including but not limited, hair, clothing, sinks, floors, towels, rugs, walls . . . to infinity. The important aspect of my invention is the formula has a reduction or near elimination of the standard toothpaste formula—of certain additives that make toothpaste stiff, cement-like and sticky. My formula reduces or eliminates thickness—carrageenan, cellulose gum, glycerin, in any amount and various degrees, enough of a reduction in these elements to render the tooth “paste” liquid.The toothpaste of this invention is a toothpaste that has a reduction or near elimination of certain additives that make standard toothpaste stiff, cement-like and sticky. The toothpaste formula reduces or eliminates carrageenan, cellulose gum, glycerin, in any amount and various degrees, enough of a reduction in these elements to render the tooth “paste” liquid.My formula will be in liquid form, with/without abrasives, with/without SLS, can include colorings, flavorings, preservatives, sorbital, water, xylitol, sweeteners, fluoride, etc.This new “toothpaste” formula will be sanitary—multiple users will not need to touch the dispenser with their toothbrush because the formula will need to be dispersed in a pump-like dispenser similar to that used with soft soap. There will be no spreading of germs.Due to the softer, more liquid form of this toothpaste, this will not stick to sinks, floors, clothing, hair , etc . . . etc . . . there will be no messy, daily cleanup from the sticky, cement like quality of regular toothpaste. ...

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Номер записи: 95
29-08-2013 дата публикации

Alcohol-free slightly-alcoholic oral care composition and a process for preparing same

Номер: US20130224125A1
Автор: Narayanan S. Kolazi, Robert J. Corring, William E. Prosise
Принадлежит: Individual

An aqueous, heat and cold stable, non-alcoholic or slightly-alcoholic microemulsion based antimicrobial mouthwash composition with improved antimicrobial efficacy. The composition comprises a unique water-soluble matrix composite, at least one water-immiscible or water-insoluble antimicrobial agent, and optionally, a preservative or preservative system, a weak carboxylic acid, a coloring agent and other additives. Examples of antimicrobial agents include menthol, thymol, eucalyptol and/or methyl salicylate. A process for preparing the oral care composition is also disclosed.

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Номер записи: 96
29-08-2013 дата публикации

Oral Care Product and Methods of Use and Manufacture Thereof

Номер: US20130224126A1
Автор: Arvanitidou Evangelia S., Cuiule Christine, Dillon Rensl, Lewus Catherine, Mello Sarita, Nesta Jason, Smith-Webster Kimdra, Szewczyk Gregory
Принадлежит: Colgate-Palmolive Company

This invention relates to a mouthwash comprising an aqueous solution of an effective amount of a basic amino acid, in free or salt form together with an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, phenoxyethanol, and combinations thereof; as well as to methods of using and of making such compositions. 1. A mouthwash comprising an aqueous solution ofa. an effective amount of a basic amino acid, in free or salt form;b. an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, phenoxyethanol, and combinations thereof.2. The mouthwash of wherein the basic amino acid is arginine or a salt thereof.3. The mouthwash of wherein the basic amino acid is present in an amount corresponding to 0.01 to 2 wt. % of the total composition weight claim 1 , the weight of the basic amino acid being calculated as free base form.4. The mouthwash of wherein the preservatives are present claim 1 , separately or in combination claim 1 , in amounts as follows:a. MIT: 0.0005-0.03 wt. %b. benzyl alcohol: 0.05-0.25 wt. %c. phenoxyethanol: 0.1-0.7 wt. %.5. A mouthwash according to further comprising a pyrophosphate.6. A mouthwash according to further comprising a synthetic anionic polymeric polycarboxylate.7. A mouthwash according to further comprising a fluoride ion source.8. A mouthwash according to wherein the mouthwash is ethanol-free.9. A mouthwash according to further comprising one or more of humectants claim 1 , flavorings claim 1 , and surfactants.10. A mouthwash according to wherein the preservative comprises an amount effective to provide microbial control.11. A method to improve oral health comprising applying an effective amount of the mouthwash of any of the preceding claims to the oral cavity of a subject in need thereof toa. reduce or inhibit formation of dental caries,b. reduce, repair or inhibit early enamel lesions,c. reduce or inhibit demineralization and promote remineralization of the ...

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Номер записи: 97
29-08-2013 дата публикации

Oral Care Composition Comprising Arginine and Calcium Carbonate

Номер: US20130224270A1
Автор: Robinson Richard, SIMON Eric
Принадлежит: Colgate-Palmolive Company

This invention relates to oral care compositions comprising a basic amino acid or salt thereof, and an abrasive system comprising natural calcium carbonate and precipitated calcium carbonate; and to methods of using and of making these compositions. 2. The composition according to having precipitated calcium carbonate (PCC) having an average particle size of 1-5 microns.3. (canceled)4. The composition according to claim 1 , further comprising an effective amount of a fluoride source.5. The composition according to claim 1 , wherein the basic amino acid in free or salt form is arginine bicarbonate.6. The composition according to claim 1 , wherein the basic amino acid is present in an amount corresponding to 1% to 15% of the total composition weight claim 1 , the weight of the basic amino acid being calculated as free base form.7. (canceled)8. The composition according to wherein the ratio of natural calcium carbonate to precipitated calcium carbonate is from 1:2 to 1:3.9. The composition according to claim 1 , wherein the natural calcium carbonate is present in an amount of 5%-20% by weight of the composition and the precipitated calcium carbonate is present in an amount of 10% to 35% by weight of the composition.10. (canceled)11. The composition according to claim 9 , wherein the natural calcium carbonate is present in an amount of about 10% and the precipitated calcium carbonate is present in an amount of about 25% by weight of the composition.12. The composition according to claim 1 , further comprising an anionic surfactant.13. The composition according to claim 1 , further comprising an antibacterial agent.14. The composition according to claim 1 , further comprising an anionic polymer.15. The composition according to claim 1 , in the form of a toothpaste further comprising one or more of water claim 1 , abrasives claim 1 , surfactants claim 1 , foaming agents claim 1 , vitamins claim 1 , polymers claim 1 , enzymes claim 1 , humectants claim 1 , thickeners claim ...

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Номер записи: 98
29-08-2013 дата публикации

Oral Compositions Containing Microaggregates

Номер: US20130224271A1
Автор: Guofeng Xu, Lin Fei, Steven Miller, Ying Yang
Принадлежит: Colgate Palmolive Co

The invention relates to a composite and oral care compositions for use in the mouth to retard the accumulation of dental plaque and/or calculus. The composite is a microaggregate comprising polymer coated, surfactant stabilized particles of a substantially insoluble metal, metal salt or metal oxide, for example zinc oxide. Also methods for retarding the accumulation of dental plaque and/or calculus are provided.

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Номер записи: 99
29-08-2013 дата публикации

MICROBEADS FOR DENTAL USE

Номер: US20130224690A1
Автор: Karlinsey Robert L.
Принадлежит:

A method for decreasing dental hypersensitivity, including sizing a plurality of non-functionalized microbeads to be between 0.01 μm to 3 μm in diameter, suspending the plurality of non-functionalized microbeads in a fluid matrix to define a dental delivery composition, introducing the dental delivery composition into an oral cavity, introducing respective non-functionalized microbeads into a dental tubule, adhering respective functionalized microbeads each other and to the dental tubule to define an aggregate, and occluding the dental tubule with the aggregate. 1. A dental system , comprising:a dental matrix fluid; anda plurality of generally spherical non-functionalized metal oxide microbeads suspended in the dental matrix fluid;wherein each respective microbead is between about 0.01 micron and about 3 microns in diameter,2. The dental system of wherein the dental matrix fluid includes fluoride.3. The dental system of wherein the microbeads are silica.4. The dental system of wherein the microbeads are selected from the group including titania claim 1 , alumina claim 1 , silica claim 1 , and combinations thereof.5. A method for decreasing dental hypersensitivity claim 1 , comprising:a) selecting a plurality of non-functionalized microbeads;b) introducing the plurality of non-functionalized microbeads into the oral cavity;c) positioning respective non-functionalized microbeads into dental tubules; andd) occluding dental tubules with non-functionalized microbeads.6. The method of wherein the microbeads are generally composed of silica.7. The method of wherein each respective microbead is between 0.01 μm to 3 μm in diameter.8. The method of claim 5 , wherein the plurality of microbead is suspended in a dental vehicle claim 5 , wherein the dental vehicle is selected from the group comprising varnishes claim 5 , dentifrices claim 5 , mouthwashes claim 5 , and combinations thereof.9. A method for decreasing dental hypersensitivity claim 5 , comprising:{'b': '82', 'a) ...

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Номер записи: 100