Oral care product and methods of use and manufacture thereof

This invention relates to a mouthwash comprising an aqueous solution of an effective amount of a basic amino acid, in free or salt form together with an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, phenoxyethanol, and combinations thereof; as well as to methods of using and of making such compositions.

Preservative System

Provided herein is a cost-effective and potent preservative system for a composition comprising a salicylate salt and a benzoate salt in an amount of from 0.2 weight % to 0.5 weight % by total weight of the composition and in a molar ratio of salicylate to benzoate of 1:6 to 1:1.2, wherein the composition has a pH of 5 or less. Further provided herein is a method of using a combination of a salicylate salt and a benzoate salt in a preservative system in a composition, and a method of preserving a composition.

Oral care product and methods of use and manufacture thereof

This invention relates to a mouthwash comprising an aqueous solution of an effective amount of a basic amino acid, in free or salt form together with an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, phenoxyethanol, and combinations thereof; as well as to methods of using and of making such compositions.

Oral care product and methods of use and manufacture thereof

This invention relates to a dual phase mouthwash comprising a hydrophilic phase, a hydrophobic phase, and a hydrotrope, wherein the hydrophilic phase comprises an effective amount of a preservative selected from methylisothiazolinone, sodium benzoate, potassium sorbate, and combinations thereof, as well as to methods of using and of making such compositions.

Oral care product and methods of use and manufacture thereof

This invention relates to a mouthwash comprising an aqueous solution of an effective amount of an orally acceptable, soluble zinc salt together with an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, glycerol monocaprylate, and combinations thereof; as well as to methods of using and of making such compositions.

Oral care product and methods of use and manufacture thereof

This invention relates to a dual phase mouthwash comprising a hydrophilic phase, a hydrophobic phase, and a hydrotrope, wherein the hydrophilic phase comprises an effective amount of a preservative selected from methylisothiazolinone, sodium benzoate, potassium sorbate, and combinations thereof, as well as to methods of using and of making such compositions.

Fluoride free and anionic surfactant free dentifrice having a high micro efficacy

An oral care composition and method are described in which the composition is free of an anionic surfactant and a fluoride source.

Oral Care Product and Methods of Use and Manufacture Thereof

This invention relates to a mouthwash comprising an aqueous solution of an effective amount of a basic amino acid, in free or salt form together with an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, phenoxyethanol, and combinations thereof; as well as to methods of using and of making such compositions. 1. A mouthwash comprising an aqueous solution ofa. an effective amount of a basic amino acid, in free or salt form;b. an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, phenoxyethanol, and combinations thereof.2. The mouthwash of wherein the basic amino acid is arginine or a salt thereof.3. The mouthwash of wherein the basic amino acid is present in an amount corresponding to 0.01 to 2 wt. % of the total composition weight claim 1 , the weight of the basic amino acid being calculated as free base form.4. The mouthwash of wherein the preservatives are present claim 1 , separately or in combination claim 1 , in amounts as follows:a. MIT: 0.0005-0.03 wt. %b. benzyl alcohol: 0.05-0.25 wt. %c. phenoxyethanol: 0.1-0.7 wt. %.5. A mouthwash according to further comprising a pyrophosphate.6. A mouthwash according to further comprising a synthetic anionic polymeric polycarboxylate.7. A mouthwash according to further comprising a fluoride ion source.8. A mouthwash according to wherein the mouthwash is ethanol-free.9. A mouthwash according to further comprising one or more of humectants claim 1 , flavorings claim 1 , and surfactants.10. A mouthwash according to wherein the preservative comprises an amount effective to provide microbial control.11. A method to improve oral health comprising applying an effective amount of the mouthwash of any of the preceding claims to the oral cavity of a subject in need thereof toa. reduce or inhibit formation of dental caries,b. reduce, repair or inhibit early enamel lesions,c. reduce or inhibit demineralization and promote remineralization of the ...

Oral Care Product and Methods of Use and Manufacture Thereof

This invention relates to a mouthwash comprising an aqueous solution of an effective amount of an orally acceptable, soluble zinc salt together with an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, glycerol monocaprylate, and combinations thereof; as well as to methods of using and of making such compositions. 1. A mouthwash comprising an aqueous solution ofa. an effective amount of an orally acceptable soluble zinc salt, wherein the zinc salt is present in an amount corresponding to 0.05 to 2 wt %; andb. an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, glycerol monocaprylate, and combinations thereof.2. The mouthwash of wherein the zinc salt is zinc citrate.3. The mouthwash of wherein the preservatives are present claim 1 , separately or in combination claim 1 , in amounts as follows:a. MIT: 0.0005-0.1 wt. %b. benzyl alcohol: 0.05-0.25 wt. %c. glycerol monocaprylate: 0.01%-0.25 wt. %.4. A mouthwash according to further comprising a pyrophosphate.5. A mouthwash according to further comprising a synthetic anionic polymeric polycarboxylate.6. A mouthwash according to further comprising a fluoride ion source.7. A mouthwash according to which is ethanol-free.8. A mouthwash according to further comprising one or more of humectants claim 1 , flavorings claim 1 , and surfactants.9. A mouthwash according to wherein the preservative comprises an amount effective to provide microbial control.10. A method to improve oral health comprising applying an effective amount of the mouthwash of any of the preceding claims to the oral cavity of a subject in need thereof toa. reduce or inhibit formation of dental caries,b. reduce, repair or inhibit early enamel lesions,c. reduce or inhibit demineralization and promote remineralization of the teeth,d. reduce hypersensitivity of the teeth,e. reduce or inhibit gingivitis,f. promote healing of sores or cuts in the mouth,g. inhibit microbial ...

Oral Care Product and Methods of Use and Manufacture Thereof

This invention relates to a dual phase mouthwash comprising a hydrophilic phase, a hydrophobic phase, and a hydrotrope, wherein the hydrophilic phase comprises an effective amount of a preservative selected from methylisothiazolinone, sodium benzoate, potassium sorbate, and combinations thereof, as well as to methods of using and of making such compositions. 1. A dual phase mouthwash comprisinga hydrophilic phase, a hydrophobic phase, a hydrotrope, and a preservative wherein the preservative comprises (i) sodium benzoate and (ii) potassium sorbate and/or methylisothiazolinone and wherein the mouthwash comprises (a) 0.05%-0.5% sodium benzoate and (b) 0.05%-0.2% potassium sorbate and/or 0.0005%-0.01% MIT.2. The mouthwash of wherein the hydrotrope component comprises glycerin and/or propylene glycol.3. The mouthwash of wherein the hydrophobic phase comprises an oil selected from isopropyl myristate claim 1 , mineral oil claim 1 , an edible oil claim 1 , and combinations thereof.4. The mouthwash of wherein the hydrophilic phase comprises the hydrotrope component.5. The mouthwash of wherein the hydrophilic phase further comprises cetylpyridinium chloride claim 1 , e.g. claim 1 , in an amount of from 0.01-0.1% claim 1 , e.g. claim 1 , 0.05%.6. The mouthwash of further comprising a pyrophosphate.7. The mouthwash of further comprising a synthetic anionic polymeric polycarboxylate.8. The mouthwash of further comprising a fluoride ion source.9. The mouthwash of which is ethanol-free.10. The mouthwash of further comprising one or more of humectants claim 1 , flavorings claim 1 , and surfactants.11. The mouthwash of wherein the hydrophilic phase comprises an effective amount of the preservative.12. A method to improve oral health comprising applying an effective amount of the mouthwash of any of the preceding claims to the oral cavity of a subject in need thereof toa. reduce or inhibit formation of dental caries,b. reduce, repair or inhibit early enamel lesions,c. reduce or ...

Anhydrous Tooth Whitening Compositions Comprising Cetylpyridinium Chloride

Disclosed herein are a tooth whitening compositions comprising at least one hydrophobic polymer carrier; cetylpyridinium chloride; and at least one whitening agent, wherein the composition is free of water. Also disclosed herein are methods for reducing microbial growth on the surface of an oral care device comprising contacting the oral care device with saliva and a tooth whitening composition comprising at least one hydrophobic polymer carrier; cetylpyridinium chloride; and at least one whitening agent, wherein the composition is free of water. 1. An tooth whitening composition comprising:at least one hydrophobic polymer carrier;cetylpyridinium chloride; andat least one whitening agent;wherein the tooth whitening composition is anhydrous.2. The tooth whitening composition according to claim 1 , wherein the hydrophobic polymer carrier is a silicone pressure sensitive adhesive.3. The tooth whitening composition according to claim 1 , wherein the at least one whitening agent is hydrogen peroxide.4. The tooth whitening composition according to claim 3 , wherein the hydrogen peroxide is present in the composition in an amount ranging from about 0.1% to about 6.0% by weight relative to the total weight of the composition.5. The tooth whitening composition according to claim 1 , wherein the cetylpyridinium chloride is present in the composition in an amount ranging from about 0.05% to about 0.20% by weight relative to the total weight of the composition.6. The tooth whitening composition according to claim 1 , wherein the cetylpyridinium chloride is present in the tooth whitening composition in an amount of about 0.1% by weight relative to the total weight of the composition.7. The tooth whitening composition according to claim 1 , further comprising at least two adhesion enhancing agents.8. The tooth whitening composition according to claim 7 , wherein the at least two adhesion enhancing agents are fumed silica and petrolatum.9. The tooth whitening composition according ...

Fluoride Free and Anionic Surfactant Free Dentifrice Having a High Micro Efficacy

An oral care composition and method are described in which the composition is free of an anionic surfactant and a fluoride source. 1. An oral care composition comprising:from 15% to 35% by weight glycerin;from 17% to 45% by weight propylene glycol; andfrom 15% to 35% by weight sorbitol;wherein the composition is free of anionic surfactants and a fluoride ion source.2. The composition of claim 1 , further comprising a pH modifying agent.3. The composition of claim 1 , wherein the pH modifying agent is citric acid.4. The composition of claim 3 , wherein the composition comprises from 0.05% to 0.4% by weight of citric acid.5. The composition of claim 4 , wherein the composition comprises 0.1% w/w citric acid.6. The composition of claim 1 , wherein glycerin comprises 18% to 30% by weight of the oral care composition.7. The composition of claim 1 , wherein glycerin comprises 20% to 25% by weight of the oral care composition.8. The composition of claim 1 , wherein the propylene glycol comprises from 20% to 35% by weight of the oral care composition.9. The composition of claim 1 , wherein the propylene glycol comprises from 24% to 32% by weight of the oral care composition.10. The composition of claim 1 , wherein the propylene glycol comprises from 25% by weight of the oral care composition.11. The composition of claim 1 , wherein the sorbitol comprises 18% to 28% by weight of the oral care composition.12. The composition of claim 1 , wherein the sorbitol comprises 23% by weight of the oral care composition.14. The composition of claim 13 , wherein the challenge test value is greater than 1.15. The composition of claim 13 , wherein the composition does not contain xylitol or polyethylene glycol.16. A method of treating or preventing a disease or condition of the oral cavity comprising contacting the oral surface of a subject in need thereof claim 1 , with a composition according to . This application is a continuation application of U.S. application Ser. No. 13/574,100, ...

Oral Care Compositions and Methods of Use

This invention relates to oral care compositions comprising a basic amino acid or salt thereof, a zinc source, and a preservative, as well as to methods of using and of making these compositions. 2. The oral care composition of claim 1 , wherein the basic amino acid is present in an amount corresponding to 1% to 15% wt. of the total composition weight.3. The oral care composition of claim 1 , wherein the basic amino acid is arginine.4. The oral care composition of claim 1 , wherein the arginine is L-arginine.5. The oral care composition of claim 1 , wherein the basic amino acid is arginine bicarbonate.6. The oral care composition of claim 1 , wherein the arginine is present at about 8% wt.7. The oral care composition of claim 1 , wherein the basic amino acid is ionized by neutralization with an acid or a salt of an acid.8. The oral care composition of claim 1 , wherein benzyl alcohol is present at about 0.7% wt.9. The oral care composition of claim 1 , wherein the polyphosphate is tetrasodium pyrophosphate.10. The oral care composition of claim 1 , wherein methylisothiazolinone is present in from 0.01%-0.05% wt.11. The oral care composition of claim 10 , wherein methylisothiazolinone is present at about 0.01% claim 10 , 0.03% claim 10 , or 0.05% wt.12. The oral care composition of claim 1 , wherein sodium bicarbonate is present from 0.5%-2.0% wt.13. The oral care composition of claim 12 , wherein sodium bicarbonate is present at about 1.0% wt.14. The oral care composition of claim 1 , wherein sodium methyl cocoyl taurate (tauranol) is present from 1.0%-2.0% wt.15. The oral care composition of claim 1 , wherein the ratio of the amount of zinc oxide to zinc citrate is from 1.5:1 to 4.5:1.16. The oral care composition of claim 1 , wherein the ratio zinc oxide to zinc citrate is about 1.5:1 claim 1 , 2:1 claim 1 , 2.5:1 claim 1 , 3:1 claim 1 , 3.5:1 claim 1 , or 4:1.17. The oral care composition of claim 16 , wherein the ratio of zinc oxide to zinc citrate is 2:1.18. ...

Preservative System

Provided herein is a cost-effective and potent preservative system for a composition comprising a salicylate salt and a benzoate salt in an amount of from 0.2 weight % to 0.5 weight % by total weight of the composition and in a molar ratio of salicylate to benzoate of 1:6 to 1:1.2, wherein the composition has a pH of 5 or less. Further provided herein is a method of using a combination of a salicylate salt and a benzoate salt in a preservative system in a composition, and a method of preserving a composition. 1. A composition comprising a preservative system ,wherein the preservative system comprises a salicylate salt and a benzoate salt,wherein a total amount of the salicylate salt and the benzoate salt is from 0.2 to 0.5 weight % by total weight of the composition,wherein a molar ratio of the salicylate to the benzoate is 1:6 to 1:1.2, andwherein the pH of the composition is 5 or less.2. The composition of claim 1 , wherein the molar ratio of the salicylate salt to the benzoate salt is 1:4.5 to 1:1.2.3. The composition of claim 1 , wherein the molar ratio of the salicylate salt to the benzoate salt is 1:3.4 to 1:1.2.4. The composition of claim 1 , wherein the molar ratio of the salicylate salt to the benzoate salt is 1:6 to 1:2.3 or 1:6 to 1:3.4.5. The composition of claim 1 , wherein the molar ratio of the salicylate salt to the benzoate salt is 1:3.33.6. The composition of claim 1 , wherein the salicylate salt comprises sodium salicylate.7. The composition of claim 1 , wherein the benzoate salt comprises sodium benzoate.8. The composition of claim 1 , wherein the preservative system consists of the salicylate salt and the benzoate salt.9. The composition of claim 1 , wherein the composition is free of preservatives other than those of the preservative system.10. The composition of claim 1 , wherein the total amount of the salicylate salt and the benzoate salt is 0.3 to 0.5 weight % claim 1 , by total weight of the composition.11. The composition of claim 1 , ...

Oral care compositions and methods of use

There is provided an oral care composition comprising: a basic amino acid, in free or salt form, wherein the basic amino acid is present in an amount of from 1% to 15% wt. of the total composition weight, the weight of the basic amino acid being calculated as free base form; a mixture comprising zinc oxide and zinc citrate, wherein zinc oxide is present in an amount of from 0.75% to 1.25% wt. of the total composition weight and wherein the zinc citrate is present in an amount of from 0.25% to 0.75% wt. of the total composition weight; and benzyl alcohol in an amount of from 0.6% to 0.9% wt. of the total composition weight. The addition of benzyl alcohol in an amount of 0.6% to 0.9% wt. to the composition improves the robustness against mold.

Oral care product and methods of use and manufacture thereof

This invention relates to a mouthwash comprising an aqueous solution of an effective amount of an orally acceptable, soluble zinc salt together with an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, glycerol monocaprylate, and combinations thereof; as well as to methods of using and of making such compositions.

Oral care product and methods of use and manufacture thereof

This invention relates to a mouthwash comprising an aqueous solution of an effective amount of a basic amino acid, in free or salt form together with an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, phenoxyethanol, and combinations thereof; as well as to methods of using and of making such compositions.

Fluoride free and anionic surfactant free dentifrice having a high micro efficacy.

Se describen una composición y un método para el cuidado oral en los cuales la composición está libre de un agente tensioactivo aniónico y de una fuente de fluoruro.

PRODUCT FOR ORAL CARE AND METHOD FOR USE AND MANUFACTURE

Un lavado oral que comprende una solución acuosa de una cantidad efectiva de una sal de zinc soluble aceptable oralmente con una cantidad efectiva de un conservador seleccionado del grupo que consiste de metilisotiazolinona (MIT), alcohol bencílico, monocaprilato de glicerol, así como las combinaciones de los mismos; así como también con los métodos para la utilización y elaboración de dichas composiciones.Reivindicación 2: El lavado oral de acuerdo con la reivindicación 1 caracterizado porque la sal de zinc es citrato de zinc. Reivindicación 5: Un lavado oral de acuerdo con cualquiera de las reivindicaciones precedentes caracterizado porque comprende además un pirofosfato. Reivindicación 6: Un lavado oral de acuerdo con cualquiera de las reivindicaciones precedentes caracterizado porque comprende además un policarboxilato polimérico aniónico sintético. An oral wash comprising an aqueous solution of an effective amount of an orally acceptable soluble zinc salt with an effective amount of a preservative selected from the group consisting of methylisothiazolinone (MIT), benzyl alcohol, glycerol monocaprylate, as well as combinations of the same; as well as with the methods for the use and elaboration of said compositions. Claim 2: The oral wash according to claim 1 characterized in that the zinc salt is zinc citrate. Claim 5: An oral wash according to any of the preceding claims characterized in that it further comprises a pyrophosphate. Claim 6: An oral wash according to any of the preceding claims characterized in that it further comprises a synthetic anionic polymeric polycarboxylate.

Oral care compositions and methods of use

There is provided an oral care composition comprising: a basic amino acid, in free or salt form, wherein the basic amino acid is present in an amount of from 1% to 15% wt. of the total composition weight, the weight of the basic amino acid being calculated as free base form; a mixture comprising zinc oxide and zinc citrate, wherein zinc oxide is present in an amount of from 0.75% to 1.25% wt. of the total composition weight and wherein the zinc citrate is present in an amount of from 0.25% to 0.75% wt. of the total composition weight; and benzyl alcohol in an amount of from 0.6% to 0.9% wt. of the total composition weight. The addition of benzyl alcohol in an amount of 0.6% to 0.9% wt. to the composition improves the robustness against mold.

Oral care product and methods of use and manufacture thereof

This invention relates to a mouthwash comprising an aqueous solution of an effective amount of a basic amino acid, in free or salt form together with an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, phenoxyethanol, and combinations thereof; as well as to methods of using and of making such compositions.

Oral care product and methods of use and manufacture thereof.

Esta invención se relaciona con un enjuague bucal que comprende una solución acuosa de una cantidad efectiva de un aminoácido básico, en forma libre o una sal, junto con una cantidad efectiva de un conservador seleccionado a partir metilisotiazolinona metilisotiazolinona (MIT), bencil alcohol, fenoxietanol fenoxietanol, y combinaciones de los mismos; así como a los métodos de uso y de fabricación de tales composiciones.

Oral care product and methods of use and manufacture thereof

This invention relates to a mouthwash comprising an aqueous solution of an effective amount of a basic amino acid, in free or salt form together with an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, phenoxyethanol, and combinations thereof; as well as to methods of using and of making such compositions.

Oral care product and methods of use and manufacture thereof

This invention relates to a mouthwash comprising an aqueous solution of an effective amount of an orally acceptable, soluble zinc salt together with an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, glycerol monocaprylate, and combinations thereof; as well as to methods of using and of making such compositions.

Fluoride free and anionic surfactant free dentifrice having a high micro efficacy

Oral care product and methods of use and manufacture thereof.

Esta invención se relaciona con un lavado bucal que comprende una solución acuosa de una cantidad efectiva de una sal de zinc soluble aceptable bucalmente junto con una cantidad efectiva de un preservante seleccionado del grupo que consiste de metilisotiazolinona (MIT), alcohol bencílico, monocaprilato de glicerol, así como las combinaciones de los mismos; así como también con los métodos para la utilización y elaboración de dichas composiciones.

Oral care compositions and methods of use

Oral care product and methods of use and manufacture thereof

This invention relates to a mouthwash comprising an aqueous solution of an effective amount of a basic amino acid, in free or salt form together with an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, phenoxyethanol, and combinations thereof; as well as to methods of using and of making such compositions.

Oral care compositions and methods of use

This invention relates to oral care compositions comprising a basic amino acid or salt thereof, a zinc source, and a preservative, as well as to methods of using and of making these compositions.

Oral care product and methods of use and manufacture thereof

THIS INVENTION RELATES TO A DUAL PHASE MOUTHWASH COMPRISING A HYDROPHILIC PHASE, A HYDROPHOBIC PHASE, AND A HYDROTROPE, WHEREIN THE HYDROPHILIC PHASE COMPRISES AN EFFECTIVE AMOUNT OF A PRESERVATIVE SELECTED FROM METHYLISOTHIAZOLINONE, SODIUM BENZOATE, POTASSIUM SORBATE, AND COMBINATIONS THEREOF, AS WELL AS TO METHODS OF USING AND OF MAKING SUCH COMPOSITIONS.

Oral care product and methods of use and manufacture thereof

This invention relates to a dual phase mouthwash comprising a hydrophilic phase, a hydrophobic phase, and a hydrotrope, wherein the hydrophilic phase comprises an effective amount of a preservative selected from methylisothiazolinone, sodium benzoate, potassium sorbate, and combinations thereof, as well as to methods of using and of making such compositions.

Oral care product and methods of use and manufacture thereof

This invention relates to a dual phase mouthwash comprising a hydrophilic phase, a hydrophobic phase, and a hydrotrope, wherein the hydrophilic phase comprises an effective amount of a preservative selected from methylisothiazolinone, sodium benzoate, potassium sorbate, and combinations thereof, as well as to methods of using and of making such compositions.

Oral care compositions and methods of use

Fluoride free and anionic surfactant free dentifrice having a high micro efficacy

An oral care composition and method are described in which the composition is free of an anionic surfactant and a fluoride source, oral care composition comprising; from 15% to 35% by weight glycerin; from 17% to 45% by weight propylene glycol; and from 15% to 35% by weight sorbitol.

Oral care compositions and methods of use

This invention relates to oral care compositions comprising a basic amino acid or salt thereof, a zinc source, and a preservative, as well as to methods of using and of making these compositions.