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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 45. Отображено 42.
31-01-2019 дата публикации

BIO-FIELD EFFECT TRANSISTOR DEVICE

Номер: US20190033252A1
Автор: CHANG Hector, CHANG Yi-Hsien, CHEN Tung-Tsun, Cheng Chun-Ren, CHENG Sean, HUANG Jui-Cheng, Huang Shih-Fen, HUANG Yu-Jie, Lin Ching-Hui, Wen Chin-Hua
Принадлежит:

A bioFET device includes a semiconductor substrate having a first surface and an opposite, parallel second surface and a plurality of bioFET sensors on the semiconductor substrate. Each of the bioFET sensors includes a gate formed on the first surface of the semiconductor substrate and a channel region formed within the semiconductor substrate beneath the gate and between source/drain (S/D) regions in the semiconductor substrate. The channel region includes a portion of the second surface of the semiconductor substrate. An isolation layer is disposed on the second surface of the semiconductor substrate. The isolation layer has an opening positioned over the channel region of more than one bioFET sensor of the plurality of bioFET sensors. An interface layer is disposed on the channel region of the more than one bioFET sensor in the opening. 1. A bio-field effect transistor (bioFET) device comprising:a semiconductor substrate having a first surface and an opposite, parallel second surface; a gate formed on the first surface of the semiconductor substrate; and', 'a channel region formed within the semiconductor substrate beneath the gate and between source/drain (S/D) regions in the semiconductor substrate, wherein the channel region includes a portion of the second surface of the semiconductor substrate;, 'a plurality of bioFET sensors disposed on the semiconductor substrate, each bioFET sensor comprisingan isolation layer disposed on the second surface of the semiconductor substrate, the isolation layer having an opening positioned over the channel region of more than one bioFET sensor of the plurality of bioFET sensors; andan interface layer disposed on the channel region of the more than one bioFET sensor in the opening.2. The bioFET device of claim 1 , further comprising a plurality of access FETs claim 1 , each of the access FETs including an access gate formed on the first surface of the semiconductor substrate and a channel region formed within the ...

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Номер записи: 1
01-05-2014 дата публикации

PASSIVE SPIRAL MICROMIXER AND ITS APPLICATIONS

Номер: US20140120031A1
Автор: CHENG Jingcai, Feng Xin, Li Xiangyang, Li Yuanyuan, MAO Zaisha, Wang Xi, YANG Chao, YONG Yumei, ZHANG Guangji, Zhang Weipeng
Принадлежит:

A micro-mixer and use thereof for synthesis of barium sulfate particles is disclosed. The micro-mixer includes feeding tubes, reservoirs, a mixing channel, a buffer reservoir and a sampling tube. The mixing channel is made of hydrophobic materials and processed into a spiral structure, in which baffles are set in interval arrangement at both sides of the channel wall. The types of the baffles include leaning-forward baffles, vertical baffles and leaning-backward baffles. Setting the baffles helps produce local secondary flow in the mixer, which enhances fluids mixing process. The micro-mixer is suitable to rapid reactions or precipitation processes, whose reaction time is much less than mixing time, and has broad application prospects in many fields involving mixing reaction such as pharmaceutical and chemistry industry. 1. A passive spiral micro-mixer with baffles comprising at least two inlet fluid reservoirs , at least two inlet channels , a spiral mixing channel , baffles and a buffer reservoir ,wherein the inlet fluid reservoir is connected with a feeding tube on one end and an inlet channel on another end, and the other end of the inlet channel is connected with the spiral mixing channel; the inlet angle at the intersection between two inlet channels is α, which interchange at the spiral mixing channel;the baffles are set in interval arrangement at both sides of the spiral mixing channel wall, and they are arranged more intensively at entrance section than those at fully developed section; the angle between the baffle and the spiral mixing channel wall is β;the outlet end of the spiral mixing channel is connected with the buffer reservoir, and the sample in the buffer reservoir is collected through an outlet tube.2. The passive spiral micro-mixer according to claim 1 , wherein the micro-mixer is made of hydrophobic material such as polydimethylsiloxane or polymethyl methacrylate.3. The passive spiral micro-mixer according to claim 1 , wherein the inlet angle ...

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Номер записи: 2
09-02-2017 дата публикации

CARTRIDGE FOR PERFORMING ASSAYS IN A CLOSED SAMPLE PREPARATION AND REACTION SYSTEM

Номер: US20170036207A1
Автор: Aiello Dominic, GRAY DARREN SCOTT, KAYYEM Jon Faiz, Kroehl Peter, Wright David Walter
Принадлежит: GenMark Diagnostics, Inc.

In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence. 1. A fluid sample processing cartridge comprising: i) a substrate;', 'ii) a sample well formed in said substrate and configured to receive a volume of fluid sample;', 'iii) a closure configured to be selectively placed over said sample well;', 'iv) a first deformable fluid chamber supported on said substrate and configured to hold a fluid therein when in an undeformed state and to collapse upon application of an external compression force to expel at least a portion of the fluid from the first fluid chamber, said first deformable fluid chamber being in fluid communication with said sample well via a channel formed in said substrate;', 'v) a mixing well formed in said substrate, said mixing well being in fluid communication with said sample well via a channel formed in said substrate;', 'vi) a driven mixing apparatus disposed within said mixing well and constructed and arranged to mix the contents of said mixing well; and', 'vii) a first fluid exit port formed in the substrate, said first fluid exit port being in fluid communication with said mixing well via a channel formed in said substrate; and, 'a) a sample preparation module comprising [ 1) a top surface;', '2) a raised wall at least partially circumscribing said top surface and in fluid sealing contact with a surface of said sample preparation module to form an interstitial space between the top ...

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Номер записи: 3
23-03-2017 дата публикации

Device and method for mixing material to be mixed

Номер: US20170080395A1
Автор: Rudolf RABER, Stephan BAER
Принадлежит: FRXSH AG

A device and to the use thereof for mixing material to be mixed. A method for providing material to be mixed has the following steps:  provision of a container with a single container opening and an inner chamber which contains an initial filling,  surrounding the container with a jacket,  introduction of a mixer such that the mixer protrudes into the inner chamber of the container, wherein the mixer is connected to a drive unit or the mixer can be connected to a drive unit in a subsequent step,  rotary driving of the mixer using the drive unit in order to provide the material to be mixed by mixing the initial filling,  removal of the mixer from the inner chamber of the container,  separation of container and jacket in order to provide the container with all of the material to be mixed located inside, for consumption.

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Номер записи: 4
07-06-2018 дата публикации

Microstructure flow mixing devices

Номер: US20180154319A1
Автор: Brian Edward Richardson
Принадлежит: Imagine TF LLC

Microstructure flow mixing devices are disclosed herein. An example device a first panel, a first plurality of raised features extending from a first surface of the first panel, a second plurality of raised features extending from the first surface of the first panel and a plurality of divider microstructures extending from the first surface of the first panel in line with and in between the first plurality of raised features and the second plurality of raised features. At least a portion of adjacent divider microstructures are spaced apart to form feed pathways or cross channels.

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Номер записи: 5
22-07-2021 дата публикации

SYSTEMS AND METHODS FOR NUCLEIC ACID PURIFICATION USING FLOW CELLS WITH ACTUATED SURFACE-ATTACHED STRUCTURES

Номер: US20210220827A1
Автор: Fisher Jay Kenneth, Spero Richard Chasen, Superfine Richard
Принадлежит:

A flow cell is provided that includes surface-attached structures in a chamber. The structures are movable in response to an actuation force. The flow cell may be utilized to extract or isolate nucleic acids from a sample flowing through the flow cell, wherein some portion of the flow cell comprises nucleic acid adsorbent material (e.g. the outer surface of the surface-attached structures, an inside surface of the chamber of the flow cell, beads attached to the outer surface of the surface-attached structures, or beads integrated into the outer surface of the surface-attached structures). Further, systems and methods for extraction of nucleic acids using such flow cells are also provided. 1. A flow cell for nucleic acid extraction , comprising:a chamber enclosing an interior and comprising a fluid inlet, a fluid outlet, and an inside surface facing the interior; anda plurality of surface-attached structures attached to the inside surface at a plurality of respective attachment sites and extending into the interior therefrom, each surface-attached structure comprising a flexible body and a metallic component disposed on or in the body,wherein application of an actuation force actuates the surface-attached structure into movement relative to the corresponding attachment site;wherein the flow cell does not include any binding agents disposed on or integrated with the outer surface of the surface-attached structures, or disposed on or integrated with the inside surface of the chamber of the flow cell; andwherein the outer surface of the surface-attached structures and the inside surface of the chamber of the flow cell each comprise nucleic acid adsorbent material.2. A system for nucleic acid extraction comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the flow cell of ; and'}a driver configured for applying an actuation force to the interior of the flow cell to actuate movement of the surface-attached structures.3. The system of claim 2 , wherein the nucleic ...

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Номер записи: 6
20-07-2017 дата публикации

APPARATUS AND METHOD FOR SELF-CLEANING BLENDER SYSTEM

Номер: US20170202397A1
Автор: Pineda Elvine, Udomphol Matthew, Vu My
Принадлежит:

A system for processing foodstuffs includes a chamber including foodstuffs, a blade assembly, and a processor. The blade assembly includes blades configured to rotate within the chamber based on initiation of a blend cycle. The processor is configured to determine a trigger event to initiate a cleaning cycle of the blade assembly to remove foodstuffs remaining in the chamber, and execute the cleaning cycle, responsive to detecting the trigger event, by causing fluid to be injected into the chamber, causing the blades of the blade assembly to rotate for a predetermined amount of time, and cause removal of at least a portion of the fluid and the remaining foodstuffs from the chamber. 1. A method for automatically cleaning a blending apparatus , comprising:initiating a blend cycle to cause blades of a blade assembly of the blending apparatus to rotate within a chamber including foodstuffs;determining, by a processor, a trigger event to initiate a cleaning cycle of the blade assembly to remove foodstuffs remaining in the chamber; and injecting fluid into the chamber;', 'rotating the blades of the blade assembly for a predetermined amount of time; and', 'removing at least a portion of the fluid and the remaining foodstuffs from the chamber., 'responsive to detecting the trigger event, executing the cleaning cycle, the cleaning cycle comprising'}2. The method of claim 1 , wherein the trigger event is based on at least one of a predetermined number of blend cycles claim 1 , a removal of a container from the blending apparatus claim 1 , or a predetermined time duration having passed since a previous cleaning cycle.3. The method of claim 1 , wherein rotating the blades of the blade assembly includes rotating the blades at half of a maximum speed.4. The method of claim 1 , wherein injecting fluid into the chamber includes releasing fluid from a fluid injector toward the blade assembly.5. The method of claim 1 , wherein the cleaning cycle further comprises actuating a blade ...

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Номер записи: 7
20-07-2017 дата публикации

Apparatus and method for controlled blender locking mechanism

Номер: US20170202398A1
Автор: Elvine PINEDA, Matthew UDOMPHOL, My Vu
Принадлежит: North American Robotics Corp

A system for processing foodstuffs includes a container platform, a blade platform, and a locking mechanism. The container platform defines a container receptacle configured to receive a container including foodstuffs. The blade platform includes blades configured to rotate to process the foodstuffs. The locking mechanism is configured to couple the container platform to the blade platform to form a blending chamber including the blades and the container subsequent to determining that the container is received by the container receptacle and prior to rotation of the blades.

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Номер записи: 8
28-07-2016 дата публикации

Device and method for stirring at least one liquid

Номер: US20160214105A1
Автор: Arne Kloke, Felix VON STETTEN, Jens Liebeskind, Nils Paust
Принадлежит: Hann-Schickard-Gesellschaft fuer Angewandte Forschung eV

A device for stirring at least one liquid includes a fluidics module rotatable about an axis of rotation, a liquid chamber for the liquid within the fluidics module, an introducer for introducing mutually separate phase volumes of a phase different from the liquid, said phase volumes having a different density than the liquid, into the liquid within the liquid chamber, and a driving device for subjecting the fluidics module to such a rotation that the phase volumes are moved radially inward or outward in relation to the axis of rotation through the liquid due to the different density of the phase volumes and of the liquid and due to the centrifugal forces caused by the rotation.

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Номер записи: 9
06-08-2020 дата публикации

Turntable color machine

Номер: US20200246767A1
Автор: Huan LI, Ruhua SHEN
Принадлежит: Zhengzhou Sanhua Technology and Industry Co Ltd

The present invention provides a turntable color machine includes a rack, a controller is arranged on the rack, a wheel-type turntable that rotates vertically is arranged on the rack, a plurality of color paste bags are arranged on the wheel-type turntable, the color paste bags are evenly arranged along the circumference of the wheel-type turntable, the color paste bags are connected with a piston pump that is driven by a lifting mechanism to perform constant volume injection via a valve body, and a material receiving device that moves up and down is arranged at the middle of the wheel-type turntable. The piston pump is connected with the color paste bags to achieve volume injection, the wheel-type turntable drives the color paste bags to perform a circular motion, so that the color paste in the color paste bags are turned up and down to achieve an even mixing effect, no stirring device needs to be added, so that the manufacturing cost is reduced, the plunger valves are arranged in the color paste bags, the air in the color paste bags is extracted through the air suction cylinder to ensure that there is no air in the color paste bags, to prevent the color paste from deteriorating and to prolong the service life of the color paste.

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Номер записи: 10
06-08-2020 дата публикации

BLENDING MODULE AND CONTROL METHODS

Номер: US20200246768A1
Автор: Fukuba Daniel, Klein Stephen, MOON Robert
Принадлежит:

One variation of a method for blending food products includes: receiving a cup containing food products; locating a lip of the cup on a lower seat of a cup plate; rotating a blend plate about a pivot axis from a blend position to a closed position to locate an upper seat of the blend plate against the lip of the cup; driving the cup plate, about the pivot axis, toward the blend position; driving the blend plate against the cup plate to seal the upper seat against the lip of the cup; activating a blender blade of the blend plate to blend food products in the cup; driving the cup plate against the blend plate to seal the upper seat against the lip of the cup; driving the blend plate toward the closed position; rotating the blend plate toward the blend position; and delivering the cup. 1. A method for blending food products comprises , during a blend cycle:raising a cup platform from a retracted position, through a cup bore in a cup plate occupying an upright position, to an extended position above the cup plate to receive a cup containing food products;lowering the cup platform from the extended position, through the cup bore, to the retracted position to locate a lip of the cup on a lower seat of the cup plate, the cup bore longitudinally offset from the pivot axis and encircled by the lower seat;rotating a blend plate about the pivot axis from a blend position to a closed position to locate an upper seat in the blend plate against the lip of the cup, the blend plate comprising a blender blade, the blender blade encircled by the upper seat and facing the cup bore when the blend plate and the cup plate occupy the blend position; driving the cup plate, about the pivot axis, toward the blend position; and', 'driving the blend plate against the cup plate to seal the lower seat of the cup plate and the upper seat of the blend plate against the lip of the cup; and, 'during a first transition periodduring a blend period succeeding the first transition period, activating the ...

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Номер записи: 11
20-09-2018 дата публикации

FLOW CELLS UTILIZING SURFACE-ATTACHED STRUCTURES, AND RELATED SYSTEMS AND METHODS

Номер: US20180266951A1
Автор: Fisher Jay Kenneth, Spero Richard Chasen, Superfine Richard
Принадлежит:

A flow cell is provided that includes surface-attached structures in a chamber. The structures are movable in response to a magnetic or electric field. A target extraction or isolation system includes the flow cell and a driver configured for applying a magnetic or electric field to the interior of the flow cell to actuate movement of the structures. The flow cell may be utilized to extract or isolate a target from a sample flowing through the flow cell. Further, a microfluidic system is provided that includes surface-attached structures and a microarray, wherein actuated motion of the surface-attached structures is used to enhance flow, circulation, and/or mixing action for analyte capture on the microarray. 1. A flow cell , comprising:a chamber enclosing an interior and comprising a fluid inlet, a fluid outlet, and an inside surface facing the interior; anda plurality of surface-attached structures attached to the inside surface at a plurality of respective attachment sites and extending into the interior therefrom, each surface-attached structure comprising a flexible body and a metallic component disposed on or in the body, wherein application of a magnetic or electric field actuates the surface-attached structure into movement relative to the corresponding attachment site.2. The flow cell of claim 1 , comprising a binding agent configured for binding to atarget present in the interior, the binding agent selected from the group consisting of:a binding agent disposed on or integrated with an outer surface of at least some of the surface-attached structures;a binding agent disposed on or integrated with the inside surface; andboth of the foregoing.3. The flow cell of claim 2 , wherein at least one of the target and the binding agent is selected from the group consisting of: a biological cell; an intracellular component; a microbe; a pathogen; a carcinogen; an antigen; a hapten; an antibody; a toxin; a drug; a steroid; a vitamin; a biopolymer a biological compound; ...

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Номер записи: 12
29-08-2019 дата публикации

BLENDING APPARATUS AND METHODS

Номер: US20190261815A1
Автор: Dickson, Elgaaen B. Shawn, Jimenez Javier E., JR. Thomas D., Triplett Tyson D., Voorhees C. David
Принадлежит: IDEYA LABS, LLC

Blending devices can be used to blend material directly in a container such as a disposable container, such as a paper or plastic cup. In some instances, a disposable container can be coupled to an adapter that includes a blade assembly to blend a food product. The food product can be blended directly within the container when the container is coupled to the adapter and supported with a support sleeve that at least partially surrounds an exterior of the disposable container. In further instances, a stand can selectively couple with multiple different sizes of sleeves and disposable containers to the adapter. The food product can be blended directly within the disposable container without causing damage or flex to the disposable container. 1. A blender assembly for blending food products in a disposable container , the assembly comprising:a blender adapter comprising a blade;a disposable container configured to contact the blender adapter such that an interior of the disposable container is accessible to the blade;a support sleeve configured to at least partially surround an exterior of a sidewall of the disposable container; anda stand configured to support the support sleeve and the disposable container and releasably couple with the blender adapter to secure together the support sleeve, the disposable container, and the blender adapter.2. The assembly of claim 1 , wherein the support sleeve prevents the disposable container from flexing while blending food products.3. The assembly of further comprising a base portion configured to connect with the blender adapter claim 1 , the base portion housing a motor and a motor drive shaft configured to rotate the blade.4. The assembly of claim 1 , wherein an interior shape of the support sleeve corresponds to an exterior shape of the disposable container.5. The assembly of claim 1 , wherein the support sleeve is proximate a mouth of the disposable container and covers approximately one third of the sidewall of the ...

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Номер записи: 13
28-09-2017 дата публикации

NOZZLE APPARATUS AND METHODS FOR USE THEREOF

Номер: US20170274380A1
Автор: SPENCE John, Wang Dingjie, WEIERSTALL Uwe
Принадлежит:

Nozzle Assemblies and methods of use for producing a liquid jet are disclosed that may be permit adjustable time delays between mixing of fluids and observation of reactions. An example nozzle assembly includes: a housing having an inlet and an outlet and a first channel defined therebetween, where the housing includes a gas focusing aperture defining the housing outlet; an intermediate tube disposed within the first channel of the housing, where the intermediate tube has an inlet and an outlet and defines a second channel therebetween; and a central tube disposed within the second channel of the intermediate tube, where the central tube has an inlet and an outlet and defines a third channel therebetween, where the central tube outlet is longitudinally spaced apart from the intermediate tube outlet such that the intermediate tube outlet is disposed between the central tube outlet and the gas focusing aperture's inlet. 1. A nozzle assembly comprising:a housing having an inlet and an outlet and a first channel defined therebetween, wherein the housing includes a gas focusing aperture that defines the outlet of the housing;an intermediate tube disposed within the first channel of the housing, wherein the intermediate tube has an inlet and an outlet and defines a second channel therebetween; anda central tube disposed within the second channel of the intermediate tube, wherein the central tube has an inlet and an outlet and defines a third channel therebetween, wherein the outlet of the central tube is longitudinally spaced apart from the outlet of the intermediate tube such that the outlet of the intermediate tube is disposed between the outlet of the central tube and an inlet of the gas focusing aperture.2. The nozzle assembly of claim 1 , wherein the housing claim 1 , the intermediate tube and the central tube are arranged coaxially with respect to one another.3. The nozzle assembly of claim 1 , wherein an inner diameter of the housing is greater than an outer ...

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Номер записи: 14
06-10-2016 дата публикации

Slip Chip Device and Methods

Номер: US20160288121A1
Автор: Chen Delai, Du Wenbin, Ismagilov Rustem F., Kreutz Jason Eugene, Li Liang, Nichols Kevin Paul Flood, Shen Feng
Принадлежит:

A device is described having a first surface having a plurality of first areas and a second surface having a plurality of second areas. The first surface and the second surface are opposed to one another and can move relative to each other from at least a first position where none of the plurality of first areas, having a first substance, are exposed to plurality of second areas, having a second substance, to a second position. When in the second position, the plurality of first and second areas, and therefore the first and second substances, are exposed to one another. The device may further include a series of ducts in communication with a plurality of first second areas to allow for a substance to be disposed in, or upon, the plurality of second areas when in the first position. 1. An apparatus for determining the quantity of an analyte present in a sample , the apparatus comprising: a top plate comprising a plurality of areas arranged to form a plurality of rows extending parallel to one another; and a bottom plate comprising a plurality of areas arranged to form a plurality of rows extending parallel to one another , and a plurality of channels extending perpendicularly to the plurality of rows of the bottom plate; wherein the top plate and the bottom plate are assembled together so that the top plate is on top of the bottom plate and the areas of the top plate communicate with the areas of the bottom plate so as to form a plurality of rows; wherein at least one of the top plate and the bottom plate is configured to slide relative to the other of the top plate and the bottom plate in order to form a plurality of columns , with each of the plurality of columns in communication with each of the plurality of channels; and wherein the areas in the top plate and the areas in the bottom plate extend at a 45 degree angle relative to the axis of a row.2. The apparatus of claim 1 , wherein the top plate is transparent.3. The apparatus of claim 1 , wherein at least one ...

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Номер записи: 15
13-10-2016 дата публикации

AUTOMATED FOOD PROCESSING SYSTEM AND METHOD

Номер: US20160296073A1
Автор: Pineda Elvine, Udomphol Matthew, Vu My
Принадлежит:

A system for food preparation, including a system body, a blade actuator retained by the system body; a set of blades; a blade platform rotatably mounting the set of blades, the blade platform pivotally connected along a first edge to the system body and operable between an engaged position and a disengaged position; and a container platform defining a container receptacle, the container platform pivotally connected along a first edge to the system body and operable between a loading position and a processing position. 112-. (canceled)13. A method for preparing frozen foodstuff with a system , the frozen foodstuff contained within a container defining a container opening , the method comprising:determining receipt of the container within a container receptacle;automatically sealing a blade assembly against the container opening, the blade assembly comprising a set of blades;automatically engaging the set of blades with a blade actuator;automatically rotating the set of blades with the blade actuator; andautomatically disengaging the blade assembly from the container.14. The method of claim 13 , wherein sealing a blade assembly against the container opening forms a blending unit claim 13 , wherein engaging the set of blades with the blade actuator comprises inverting the blending unit against the blade actuator claim 13 , and wherein the method further comprises uprighting the blending unit after automatically rotating the set of blades with the blade actuator.15. The method of claim 14 , further comprising automatically agitating the blending unit during automatically rotating the set of blades with the blade actuator.16. The method of claim 15 , wherein rotating the set of blades with the blade actuator comprises blending the foodstuff within the container claim 15 , wherein agitating the blending unit comprises uprighting claim 15 , then inverting claim 15 , the blending unit part way through blending the foodstuff.17. The method of claim 13 , further comprising ...

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Номер записи: 16
19-09-2019 дата публикации

SINGLE-USE FOOD PREPARATION CONTAINER ASSEMBLY, SYSTEM AND METHOD

Номер: US20190282034A1
Автор: BRONKHORST Joris, DIKHOFF Hans Constant, KUSTER Johannes Gabriel, LEIJENAAR Sybren Yme, MALTHA KRIJN, NIJSEN Andreas Jacobus Louis, OZANA Shalom, STERNGOLD Ariel, WEIJERS Marcel Hendrikus Simon
Принадлежит:

A product preparation system and method wherein a single-use product container assembly and a multiple motion intelligent driving device are employed to process contents of the container assembly. 1. A single-use product preparation container assembly comprising:a container body for containing a product prior to, during and following preparation thereof; and it limits ingress therethrough of contaminants from outside into said product preparation enclosure;', 'it limits egress therethrough of product from said enclosure; and', 'it limits contamination of product in said enclosure by disengaged components thereof., 'a single-use container body closure assembly defining with said container body a product preparation enclosure and including an externally rotatably drivable rotary product engagement assembly characterized in that2181.-. (canceled)182. A single-use product preparation container assembly according to and wherein said externally rotatably drivable rotary product engagement assembly comprises a rotatable blade assembly.183. A single-use product preparation container assembly according to and wherein said rotatable blade assembly is linearly displaceable along an axis in said single-use container body closure assembly.184. A single-use product preparation container assembly according to and wherein said rotatable blade assembly is rotatable about a rotation axis and displaceable along said rotation axis with respect to said container body at least between a first position and a second position.185. A single-use product preparation container assembly according to and wherein said single-use container body closure assembly comprises:a lid having a recess formed therein; anda rotatable blade assembly located on said lid for engaging contents of said container body, said rotatable blade assembly and said lid being relatively at least linearly moveable with respect to each other at least between a first retracted orientation wherein said rotatable blade assembly ...

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Номер записи: 17
15-11-2018 дата публикации

FLUIDIC DEVICE

Номер: US20180328831A1
Автор: COHEN SAMUEL, Dobson Christopher, KNOWLES Tuomas, Rajah Luke, White Duncan
Принадлежит: Cambridge Enterprise Limited

Methods for determining the lateral diffusion of one or more components are provided. 138-. (canceled)39. A method for determining the diffusion coefficient of two or more components , the method comprising the steps of:(i) providing a component fluid flow comprising two or more components;(ii) providing a blank fluid flow;(iii) flowing the component fluid flow and the blank fluid flow laminarly in a channel; and (iv) measuring lateral diffusion of the two or more components from the component flow into the blank fluid flow at a plurality of diffusion times.40. The method according to claim 39 , wherein the lateral diffusion is measured at three or more diffusion times.41. The method according to claim 39 , wherein the method further comprises a step (v) wherein a diffusion coefficient value for a component is determined from the lateral diffusion measurements of step (iv) claim 39 , and optionally a hydrodynamic radius is determined from a diffusion coefficient value.42. The method according to claim 41 , wherein step (v) includes comparing the measured lateral diffusion profiles of the two or more components from step (iv) with a series of distributions for components having known hydrodynamic radii claim 41 , thereby to determine the hydrodynamic radii for each of the one or more components.43. The method according to claim 41 , wherein step (v) comprises deconvoluting the measured lateral diffusion profiles of the two or more components from step (iv) using a highest entropy regularisation approach with reference to a series of distributions for components having known hydrodynamic radii claim 41 , thereby to determine the hydrodynamic radii for each of the one or more components.44. The method according to claim 42 , wherein step (v) comprises deconvoluting the measured lateral diffusion profiles of the two or more components from step (iv) using a highest entropy regularisation approach with reference to a series of distributions for components having known ...

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Номер записи: 18
12-11-2020 дата публикации

An arrangement for mixing fluids in a capillary driven fluidic system

Номер: US20200353462A1
Автор: Lei Zhang
Принадлежит: miDiagnostics NV

There is provided an arrangement (100) which allows for mixing a first fluid with a second fluid at a predetermined volume mixing ratio in a capillary driven fluidic system. The arrangement (100) allows filling an initially empty mixing chamber (110) with the first fluid. The arrangement then allows emptying a predetermined fraction of the first fluid from the mixing chamber (110) such as to form an empty space in the mixing chamber (110). The arrangement then allows filling the empty space of the mixing chamber (110) with the second fluid, thereby allowing a predetermined volume of the first fluid to mix with a predetermined volume of the second fluid over time.

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Номер записи: 19
05-12-2019 дата публикации

APPARATUS AND METHOD FOR SELF-CLEANING BLENDER SYSTEM

Номер: US20190365156A1
Автор: Pineda Elvine, Udomphol Matthew, Vu My
Принадлежит:

A system for processing foodstuffs includes a container platform, a blade platform, and a locking mechanism. The container platform defines a container receptacle configured to receive a container including foodstuffs. The blade platform includes blades configured to rotate to process the foodstuffs. The locking mechanism is configured to couple the container platform to the blade platform to form a blending chamber including the blades and the container subsequent to determining that the container is received by the container receptacle and prior to rotation of the blades. 1. A system for processing foodstuffs , comprising:a container platform defining a container receptacle configured to receive a container including foodstuffs;a blade platform including blades configured to rotate to process the foodstuffs; anda locking mechanism configured to couple the container platform to the blade platform to form a blending chamber including the blades and the container subsequent to determining that the container is received by the container receptacle and prior to rotation of the blades.2. The system of claim 1 , wherein the blade platform includes a seal configured to engage at least one of the container receptacle or the container while the container platform is coupled to the blade platform.3. The system of claim 2 , wherein the seal has a seal diameter that is greater than a container diameter of a rim of the container.4. The system of claim 2 , wherein a recess of the seal defines the seal diameter.5. The system of claim 1 , wherein the locking mechanism is coupled to the blade platform and is configured to engage a lock feature of the container platform.6. The system of claim 1 , wherein the locking mechanism is configured to bias the blade platform to be adjacent to the container platform while the container platform is at a loading position at which the container receptacle receives the container.7. The system of claim 1 , wherein the blade platform is configured ...

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Номер записи: 20
16-08-2016 дата публикации

Slip chip device and methods

Номер: US9415392B2
Автор: Delai Chen, Feng Shen, Jason Eugene Kreutz, Kevin Paul Flood Nichols, Liang Li, Rustem F. Ismagilov, Wenbin Du
Принадлежит: University of Chicago

A device is described having a first surface having a plurality of first areas and a second surface having a plurality of second areas. The first surface and the second surface are opposed to one another and can move relative to each other from at least a first position where none of the plurality of first areas, having a first substance, are exposed to plurality of second areas, having a second substance, to a second position. When in the second position, the plurality of first and second areas, and therefore the first and second substances, are exposed to one another. The device may further include a series of ducts in communication with a plurality of first second areas to allow for a substance to be disposed in, or upon, the plurality of second areas when in the first position.

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Номер записи: 21
20-09-2016 дата публикации

Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes

Номер: US9447461B2
Автор: Bing Sun, Feng Shen, Jason E. Kreutz, Rustem F. Ismagilov, Wenbin Du
Принадлежит: California Institute of Technology CalTech, University of Chicago

Provided are devices and methods for effecting processing of samples, including essentially isothermal amplification of nucleic acids, at multiple reaction locations in a single device. In some embodiments, the disclosed devices and methods provide for effecting parallel sample processing in several hundred locations on a single device.

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Номер записи: 22
11-10-2016 дата публикации

Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes

Номер: US9464319B2
Автор: Bing Sun, Feng Shen, Jason E. Kreutz, Rustem F. Ismagilov, Wenbin Du
Принадлежит: California Institute of Technology CalTech, University of Chicago

Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.

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Номер записи: 23
15-11-2016 дата публикации

Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes

Номер: US9493826B2
Автор: Bing Sun, Feng Shen, Jason E. Kreutz, Rustem F. Ismagilov, Wenbin Du
Принадлежит: California Institute of Technology CalTech, University of Chicago

Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.

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Номер записи: 24
28-01-2020 дата публикации

Slip chip device and methods

Номер: US10543485B2
Автор: Delai Chen, Feng Shen, Jason Eugene Kreutz, Kevin Paul Flood Nichols, Liang Li, Rustem F. Ismagilov, Wenbin Du
Принадлежит: University of Chicago

A device is described having a first surface having a plurality of first areas and a second surface having a plurality of second areas. The first surface and the second surface are opposed to one another and can move relative to each other from at least a first position where none of the plurality of first areas, having a first substance, are exposed to plurality of second areas, having a second substance, to a second position. When in the second position, the plurality of first and second areas, and therefore the first and second substances, are exposed to one another. The device may further include a series of ducts in communication with a plurality of first second areas to allow for a substance to be disposed in, or upon, the plurality of second areas when in the first position.

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Номер записи: 25
06-08-2019 дата публикации

Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes

Номер: US10370705B2
Автор: Bing Sun, Feng Shen, Jason E. Kreutz, Rustem F. Ismagilov, Wenbin Du
Принадлежит: University of Chicago

Provided are devices and methods for effecting processing of samples, including essentially isothermal amplification of nucleic acids, at multiple reaction locations in a single device. In some embodiments, the disclosed devices and methods provide for effecting parallel sample processing in several hundred locations on a single device.

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Номер записи: 26
15-07-2014 дата публикации

Devices, apparatus, and methods employing biomimetic cilia for microfluidic manipulation

Номер: US8778666B1
Автор: Jae Chung, James J. Riley, Jiradech Kongthon, Kieseok Oh, Kyong Hoon Lee, Santosh Devasia
Принадлежит: UNIVERSITY OF WASHINGTON

A device comprises: one or more cantilevered biomimetic cilia, and a liquid disposed among the one or more biomimetic cilia, wherein individual biomimetic cilia are at least partially submerged in the liquid, and wherein the biomimetic cilia are arranged for excitation into resonance, such as for mixing and pumping via the resonant behavior of the excited cilia.

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Номер записи: 27
15-05-2018 дата публикации

Mixing machine

Номер: US9968897B2
Автор: Ulrich Tölle
Принадлежит: Dr Herfeld GmbH and Co KG

This mixing machine comprises a mixing head that attaches to a container, forming a closed mixing receptacle. The head is pivotably supported in a frame such that the closed mixing receptacle can pivot to perform the mixing. The mixing head also has a rotationally driven tool which cleans the bottom of the head, supplying a low-energy transport stream for material to at least one second tool carried by the head. The second tool performs the mixing and is located inside the movement path of the bottom-cleaning first tool. The first tool has a scoop positioned in the direction of rotation of the tool with its edge facing in the direction of rotation and outward in the radial direction. The first tool comprises a first scoop section, a second, wall-cleaning scoop section and a recess open toward its closure more remote from the wall through which the second tool passes during rotation of the first tool.

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Номер записи: 28
09-04-2019 дата публикации

Nozzle apparatus and methods for use thereof

Номер: US10252270B2
Автор: Dingjie Wang, John Spence, Uwe Weierstall
Принадлежит: Arizona Board of Regents of ASU

Nozzle Assemblies and methods of use for producing a liquid jet are disclosed that may be permit adjustable time delays between mixing of fluids and observation of reactions. An example nozzle assembly includes: a housing having an inlet and an outlet and a first channel defined therebetween, where the housing includes a gas focusing aperture defining the housing outlet; an intermediate tube disposed within the first channel of the housing, where the intermediate tube has an inlet and an outlet and defines a second channel therebetween; and a central tube disposed within the second channel of the intermediate tube, where the central tube has an inlet and an outlet and defines a third channel therebetween, where the central tube outlet is longitudinally spaced apart from the intermediate tube outlet such that the intermediate tube outlet is disposed between the central tube outlet and the gas focusing aperture's inlet.

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Номер записи: 29
30-12-2021 дата публикации

Modular microchannel thermal solutions for integrated circuit devices

Номер: US20210407888A1
Автор: Adel Elsherbini, Feras Eid, Georgios Dogiamis, Stephen Morein
Принадлежит: Intel Corp

A microfluidic device having a channel within a first material to thermally couple with an IC die. The channel defines an initial fluid path between a fluid inlet port and a fluid outlet port. A second material is within a portion of the channel. The second material supplements the first material to modify the initial fluid path into a final fluid path between the fluid inlet port and the fluid outlet port. The second material may have a different composition and/or microstructure than the first material.

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Номер записи: 30
23-09-2021 дата публикации

Capillary tube droplet generation systems and methods

Номер: US20210291129A1
Автор: Mark A. Gray
Принадлежит: Individual

A droplet generating system includes a reservoir configured to receive an organic fluid and an aqueous fluid, a barrier separating the reservoir into a first reservoir portion and a second reservoir portion, a tube, and an indexer. The barrier is capable of preventing the aqueous fluid from entering the second reservoir portion from the first reservoir portion. The tube is disposed near the barrier, and the tube has a microfluidic channel. The indexer guides the aqueous fluid and the organic fluid into the microfluidic channel so as to form droplets of the aqueous fluid.

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Номер записи: 31
20-07-2017 дата публикации

Apparatus and method for blender system with mid-cycle inversion

Номер: US20170202399A1
Автор: Elvine PINEDA, Matthew UDOMPHOL, My Vu
Принадлежит: North American Robotics Corp

A system includes a container platform configured to receive a container, a blade assembly and a blade actuator for rotating blades of the blade assembly, a blade platform, and a platform actuator for moving the blade platform between a blade engagement position and a container engagement position. A processor is configured to cause the platform actuator to move the blade platform, prior to a first actuation of the blade actuator, from the container engagement position to the blade engagement position, to cause the first actuation, to cause the platform actuator to move the blade platform towards the container engagement position, to cause the blade platform to return to the blade engagement position, to cause a second actuation of the blade actuator, and to cause the platform actuator to return the blade platform to the container engagement position subsequent to the second actuation.

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Номер записи: 32
01-05-2018 дата публикации

Fluidic device

Номер: US09958369B2
Автор: Christopher Dobson, Duncan White, Luke RAJAH, Samuel Cohen, Tuomas Knowles
Принадлежит: CAMBRIDGE ENTERPRISE LTD

A method for determining the diffusion of one or more components, the method includes the steps of (i) providing a component fluid flow having one or more components; (ii) providing a blank fluid flow; (iii) bringing the flow (i) into contact with the flow (ii) in a large cross section channel, thereby to generate two laminar flows; (iv) permitting the laminar flows generated in (iii) to flow from the large cross section channel into a small cross section channel; measuring the lateral diffusion of the one or more components from the component flow into the blank fluid flow in the small cross section channel. Also provided is a diffusion method having the steps of measuring the lateral diffusion of the one or more components from the component flow into the blank fluid flow at a plurality of diffusion times.

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Номер записи: 33
24-04-2018 дата публикации

Mixing machine and its liner

Номер: US09950301B2
Автор: Ulrich Tölle, Wolfgang Rüberg
Принадлежит: Dr Herfeld GmbH and Co KG

A mixing machine 1 comprising a mixing head 3 having element(s) for connecting to a receptacle to form a mixing container. The mixing head 3 is pivotably supported in a frame 2 such that the mixing container can pivot for the mixing process. The mixing head 3 has at least one rotationally driven mixing tool whose drive shaft 23 extends through the wall of the mixing head 3 . The mixing head 3 has a double wall with a perforated inner wall 8 . The perforations form a fluid path from the chamber surrounded by the inner wall 8 to the intermediate wall chamber 10 . The intermediate wall chamber 10 is connected to a pressure adjustment device for adjusting the pressure. A flexible liner 15 is arranged in the mixing head 3 on its inner surface, which liner 15 can be fixed to the inner wall 8 of the mixing head by applying a vacuum.

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Номер записи: 34
03-10-2017 дата публикации

Microfluid device and method of producing diffusively built gradients

Номер: US09778153B2
Автор: Roman Zantl
Принадлежит: ibidi GmbH

A microfluid device for producing diffusively built gradients comprising a bottom plate and a cover plate, wherein the cover plate has recesses and is connected to the bottom plate in a liquid-tight manner so that the recesses form at least two reservoirs and one observation chamber, which connects the reservoir, a reservoir can be filled particularly through an inlet/outlet through the cover plate, and the cross-sectional surface of the observation chamber is at least 5 times, preferably at least 200 times smaller at the aperture of the observation chamber into one of the reservoirs than the maximum cross-sectional surface of the reservoir in parallel to this cross-sectional surface of the observation chamber.

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Номер записи: 35
15-08-2017 дата публикации

Full-automatic erythrocyte sedimentation rate analysis meter and detecting method thereof

Номер: US09733175B2
Автор: Hui Yang, Kunhui Hu, Lin He, Qingbo LIU
Принадлежит: Shenzhen Yhlo Biotech Co Ltd

The invention provides a full-automatic erythrocyte sedimentation rate analyzer, which comprises a base as well as a blending device and a detecting device mounted on the base, wherein the blending device comprises a sample rack, a sample rack bracket and a rotating device; the sample rack bracket is arranged on the base, and is connected to the sample rack through a rotating shaft; more than one test tube rack is arranged on the sample rack; the rotating device is connected to the rotating shaft, and drives the rotating shaft to rotationally drive the sample rack to turn over up and down; a plurality of holes are arranged in each test tube rack; a fixing device is arranged in the hole, and used for placing and fixing a closed container containing samples; the detecting device comprises a guide device, a driving device, infrared transmitting and receiving devices having the same quantity as that of the test tube racks, and a mounting rack; the driving device drives the mounting rack to move up and down along the guide device; the mounting rack drives the infrared transmitting and receiving devices to move; the closed containers containing the samples are located on moving paths of the infrared transmitting and receiving devices; and infrared rays penetrate through the closed containers to realize detecting.

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Номер записи: 36
09-05-2017 дата публикации

Microfluidic free interface diffusion techniques

Номер: US09643136B2
Автор: Carl L. Hansen, James M. Berger, Stephen R. Quake
Принадлежит: Fluidigm Corp

A static fluid and a second fluid are placed into contact along a microfluidic free interface and allowed to mix by diffusion without convective flow across the interface. In accordance with one embodiment of the present invention, the fluids are static and initially positioned on either side of a closed valve structure in a microfluidic channel having a width that is tightly constrained in at least one dimension. The valve is then opened, and no-slip layers at the sides of the microfluidic channel suppress convective mixing between the two fluids along the resulting interface. Applications for microfluidic free interfaces in accordance with embodiments of the present invention include, but are not limited to, protein crystallization studies, protein solubility studies, determination of properties of fluidics systems, and a variety of biological assays such as diffusive immunoassays, substrate turnover assays, and competitive binding assays.

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Номер записи: 37
25-04-2017 дата публикации

Method of delivering PCR solution to microfluidic PCR chamber

Номер: US09630158B2
Автор: Hiroshi Inoue
Принадлежит: Canon US Life Sciences Inc

The present invention relates to systems and methods of performing in-line mixing of assay components and delivery of such mixed components into microfluidic channels. In one aspect, a method of delivering mixed assay components is provided which comprises causing an unmixed primer solution to flow into a first mixing channel, the unmixed primer solution comprising a common reagent and a primer, holding the unmixed primer solution in the first mixing channel for at least a threshold amount of time to allow the unmixed primer solution to transition into a mixed primer solution, causing a buffer to flow into a second mixing channel, the buffer comprising the common reagent but not including a primer, and, after holding the unmixed primer solution in the first mixing channel for at least the threshold amount of time, drawing, from the first mixing channel, the mixed primer solution into a common exit channel.

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Номер записи: 38
25-04-2017 дата публикации

Blending container for use with blending apparatus

Номер: US09629503B2
Автор: Elvine PINEDA, Matthew UDOMPHOL, My Vu
Принадлежит: North American Robotics Corp

A container includes a body including a lip portion, a base portion, and a wall structure extending between the lip portion and the base portion. The wall structure and the base portion define a cavity. The lip portion extends outwards from the wall structure. The body is configured to be received in a container receptacle defined within a container platform of a blending apparatus when the container platform is in a first position. The lip portion includes one or more engagement features to sealingly engage with a corresponding engagement feature of a blade assembly of the blending apparatus, restrict rotation of the container during rotation of blades of the blade assembly, and restrict translational motion of the lip portion relative to the surface of the container receptacle during rotation of the container platform from the first position to a second position or during rotation of the blades.

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Номер записи: 39
27-12-2016 дата публикации

Microfluidic device with integrated stirring structure and manufacturing method thereof

Номер: US09527726B2
Автор: Paolo Ferrari, Sabrina Conoci
Принадлежит: STMICROELECTRONICS SRL

A microfluidic device, comprising: a semiconductor body, having a first side and a second side, opposite to one another in a first direction; and at least one well, configured for containing a fluid, extending in the semiconductor body starting from the first side and being delimited at the bottom by a bottom surface. The microfluidic device further comprises a stirring structure integrated in the well at the bottom surface, the stirring structure including a first stirring portion coupled to the semiconductor body and provided with at least one first suspended beam configured for being moved in a second direction so as to generate, in use, agitation of the fluid present in said well.

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Номер записи: 40
20-09-2016 дата публикации

Cooking material dispensing method and dispensing system

Номер: US09446876B2
Автор: Ping Yan, Xinyu Liu
Принадлежит: Individual

Disclosed are a cooking material dispensing system and dispensing method. The dispensing method comprises the following steps: setting a material bag ( 9 ) clamping station in a position near a cooking pot opening but outside the range of the pot opening, and clamping the material bag ( 9 ) containing a cooking material at the material bag ( 9 ) clamping station; confining the material bag ( 9 ), such that the material bag ( 9 ) is kept in a clamped state to control the deformation thereof during the dispensing procedure; flipping and/or tipping the material bag ( 9 ), and when in a position near the cooking pot opening, dispensing the cooking material in the material bag ( 9 ) into the cooking pot; and once the cooking material has been dispensed, shifting the material bag ( 9 ) from the range of the cooking pot opening and releasing the clamping of the material bag ( 9 ). The cooking material dispensing system comprises a dispensing device capable of clamping, confining, and transferring the material bag ( 9 ) and flipping the opened material bag and/or tipping the cooking material into the cooking pot. The dispensing system and dispensing method take a material packaged in the material bag ( 9 ) and can accurately move the material bag ( 9 ) into the dispensing position, making the cooking process convenient, fast and simple, and the entire process will not be contaminated.

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Номер записи: 41
14-06-2016 дата публикации

Fluid processing micro-feature devices and methods

Номер: US09366606B1
Автор: Daniel R. McPeak, Ka Man Lee
Принадлежит: Ativa Medical Corp

The present description provides, in some embodiments, an apparatus for mixing a fluid in a circuit having an inlet channel defining a flow path for a fluid including particulate matter, a first reagent channel in fluid communication with the inlet channel and defining a first reagent flow path for a first reagent, the inlet channel and first reagent channel configured to shear the fluid entering the first reagent channel from the inlet channel at a first junction, a shearing channel in fluid communication with the inlet channel and first reagent channel at the first junction, and a diffusion channel in fluid communication with the shearing channel at a second junction, the sheared fluid collectable into the diffusion channel such that the fluid is compressed at least in part by the first reagent to have a thickness close to a diameter of the particulate matter in the fluid.

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Номер записи: 42