ПРОДУКТЫ ФЛЮС-КАЛЬЦИНИРОВАННОГО ДИАТОМИТА ОПАЛОВЫХ ПОРОД

Изобретение относится к фильтрующим материалам для жидкости. Предложен диатомит, подвергнутый кальцинированию под флюсом на основе карбоната натрия. Продукт диатомита имеет содержание кристаллического диоксида кремния меньше 0,1 масс. % и имеет проницаемость в пределах между 0,8 дарси и примерно 30 дарси. Продукт диатомита может содержать некоторое количество кристобалита, которое определяется с помощью метода, различающего кристобалит и опал-C, в частности, с использованием LH Method. 13 з.п. ф-лы, 33 ил., 20 табл.

СОРБЕНТ НА ОСНОВЕ МОДИФИЦИРОВАННОГО СИЛИКАГЕЛЯ

Изобретение относится к сорбентам для очистки питьевых и сточных вод. Предложен сорбент на основе модифицированного силикагеля, содержащий привитые группы N-(пропил)этилендиаминтриуксусной кислоты. Сорбент характеризуется структурной формулойКонцентрация привитых групп аминогрупп составляет 0,80 ммоль/г±10%. Изобретение обеспечивает повышение сорбционных характеристик, расширение спектра извлекаемых веществ, возможность регенерации сорбента и его вторичного использования. 6 з.п. ф-лы, 2 ил., 4 табл.

Vorrichtung zur Aufreinigung von Nukleinsäure

Affinity chromatography

A method of preparation of superfically porous particles with precisely controlled particle density, and a use thereof

Conversion of normal phase silica to reverse phase silica

PROCEDURE FOR THE CLEANING OF EXCERPTS FROM THE ZOAPATL PLANT WITH A CONTENT AT UTEROEVAKUIERENDEN SUBSTANCES

SILICON AND POLYSILYLCYAMELURATE AS WELL AS - CYANOGEN URATES, PROCEDURES FOR THEIR PRODUCTION AND THEIR USE

USE MONOLITHIC SORBENTIEN FOR PRÄPARATIVE CHROMATOGRAPHI SEPARATION PROCESSES

ENDOWED SOL GEL GLASSES FOR CHEMICAL INTERACTIONS

ZIRCONIUM OXIDE PARTICLE

High performance liquid chromatography method and apparatus

USING AMINES OR AMINO ACIDS AS MOBILE PHASE MODIFIERS IN CHROMATOGRAPHY

A PROCESS FOR THE SYNTHESIS OF A CHROMATOGRAPHIC PHASE

A process for the synthesis, delivery or deposition or localisation of a chromatographic phase, especially for chromatographic separation or solid phase extraction, comprises introducing a chemical moiety to a support using a supercritical fluid such as supercritical carbon dioxide.

A METHOD OF CHROMATOGRAPHIC ISOLATION FOR NON-GLYCERIDE COMPONENTS

A method of chromatographic isolation for non-glyceride components (squalenes, carotenes, vitamin E, sterols and/or the like) from a non-glyceride components - comprising compound by , said method including the steps of a. introducing the non-glyceride components-comprising compound onto a selective adsorbent to allow an adsorption of the non-glyceride components, and subsequently b. desorbing the non-glyceride components from the adsorbent, wherein the adsorption and/or desorption of the non-glyceride components is carried out under a supercritical fluid environment.

DIATOMITE PRODUCTS

Products (4) comprising a physical component (6) and Silica Documentation (8), and methods of preparing such products (4) are disclosed. In some embodiments, the physical component (6) may be powdered or in particulate form. The physical component (6) includes diatomite. In such products (4), a crystalline silica content of the physical component (6) by weight is greater as measured according to Traditional Methods than as measured according to a method that differentiates between opal-C and cristobalite. The Silica Documentation (8) discloses the crystalline silica content present in the physical component (6) as measured according to the method that differentiates between opal-C and cristobalite. The method of preparing the product (4) may include analyzing the physical component (6) for crystalline silica content using an LH Method to determine cristobalite content and preparing Silica Documentation (8) based on the results of the LH Method.

METHODS AND COMPOUNDS FOR CONTROLLING THE MORPHOLOGY AND SHRINKAGE OF SILICA DERIVED FROM POLYOL-MODIFIED SILANES

Siliceous materials are prepared by adding one or more additives, including water soluble polymers, and derivatives thereof, to sols containing tetraalkoxysilanes derived from polyols. The polymers facilitate phase separation of the growing silica gel matrix, leading to high surface area self- supporting silica gels with cure occurring at ambient temperatures. The materials also show a significant reduction in shrinkage properties.

MESOPOROUS PARTICLES

A method for synthesising metal oxide particles comprises preparing a pre-sol solution, and hydrolysing and condensing the pre-sol solution under supercritical fluid conditions to form macroscopic mesoporous particles having ordered pore structures. The pre-sol solution may contain a mixture of surfactants such as CTAB and P123. The supercritical fluid may be scCO2. The mesoporous particles may be spheres with a mesopore diameter in the range of 2 to 15 nm and macroscopic diameters of from 1 to 5 microns. The particles are useful in chromatography and other applications.

CLEAN, COMPRESSED SORBENT TABLETS

A pressed sorbent form includes a sorbent and a binder. The sorbent is ch osen from the group including silica gel, molecular sieve, activated carbon, and clay. The binder is powdered ethyl vinyl acetate.

METHODS OF SYNTHESIS AND PURIFICATION BY USE OF A SOLID SUPPORT

Disclosed herein are novel methods of using polymeric adsorbent resin for chemical synthesis and the purification of product therefrom. Also disclosed herein is a novel method of using silica gel for the combination of chemical reaction and chromatography into a single step. The methods disclosed herein increase the efficiency of chemical synthesis processes. Accordingly, the utility of the methods disclosed herein includes the ability to automate chemical synthesis and purification of the resulting products.

Powder for chromatographic separations

METHOD OF CHROMATOGRAPHY ON A MULTI-CAPILLARY LINING

ISOLEMENT DE SUBSTANCES D'EVACUATION UTERINE D'EXTRAITS DE PLANTES

La présente invention concerne un procédé pour purifier des extraits contenant des substances d'évacuation utérine, obtenus de la plante zoapatle. Selon l'invention, on fait réagir la 'substance semi-purifiée obtenue de l'extrait avec un agent acylant, on chromatographie le mélange réactionnel sur un matériau adsorbant, on élue le matériau adsorbant et on recueille les fractions contenant les substances acylées d'évacuation utérine. L'invention s'applique notamment à la préparation de composés ayant des propriétés d'évacuation utérine ou pouvant induire des contractions.

CORE-SHELL SILICA AND METHOD FOR PRODUCING SAME

Disclosed is a core-shell silica having high sphericity and narrow particle size distribution. Also disclosed is a method for easily producing such a core-shell silica. Specifically disclosed is a method for producing a core-shell silica, which comprises a step for preparing a dispersion liquid by dispersing substantially non-porous silica core particles having a sphericity of not less than 0.8 and a coefficient of variation of not more than 0.2 into a dispersion medium composed of an alcohol and water in the presence of a surface active agent; a step for forming a shell precursor containing silica and the surface active agent on the surface of each silica core particle by adding a silica raw material into the dispersion liquid and causing a reaction of the silica raw material at a pH of 8-13; and a step for forming a porous shell by removing the surface active agent from the shell precursor. © KIPO & WIPO 2009 ...

USING AMINES, AMINO ACIDS OR AMINO ACID ESTERS AS MOBILE PHASE MODIFIERS IN CHROMATOGRAPHY

CARBON COMPOSITE MATERIALS FOR SEPARATIONS

A composite particulate material useful in analytical separations processes includes a carbon coating deposited through chemical vapor deposition on a substantially metal-free inorganic oxide particle. The resultant laminate material may be tuned for desired sorption rates and selectivities with respect to analytes of interest.

METHOD FOR METAL COATED POROUS SCAFFOLD MATERIAL

A method for coating a porous material is provided. The method comprises diluting noble-metal paint with a solvent, flushing a porous material with the noble-metal paint, drying the porous material in air flow and applying a high temperature treatment to the porous material. The temperature treatment can include the steps of allowing the remaining solvent to evaporate at room temperature, heating the porous material up to higher than 700 o Cat rate from 5 to 20 o C/min, heating the porous material at desired maximum temperature for 10 to 30 minutes and cooling the porous material to room temperature at rate from about 5 to 20 o C/min.

SIMULTANEOUS CHEMICAL SEPARATION AND SURFACE-ENHANCED RAMAN SPECTRAL DETECTION

A stationary medium is employed both to separate chemicals from a sample solution and also for surface-enhanced Raman spectral analysis of the separated chemical, thereby greatly reducing the complexity of the apparatus and enhancing the efficiency of the chemical analysis method.

POROUS INORGANIC COMPOSITE AND METHOD FOR SEPARATING METAL ELEMENTS USING THE SAME

A porous inorganic composite comprising: an inorganic porous particle having an average diameter of 1 'mu'm to 1 mm, a porosity of 0.20 to 0.90, and an average pore diameter of 10 to 5000 nm; and an inorganic material supported on the particle.

ZIRCONIA PARTICLES

Porous zirconia or zirconium-containing particles, methods of making such particles and methods of using such particles including modifications to the surface of the particles are described. The method comprises heating zirconia particles to provide a substantially homogeneously liquid melt, quenching the particles of melt to effect spinodal decomposition to provide quench particles of a silica rich phase and a zirconia rich phase, annealing the quenched particles to provide non porous solid particles of zirconia and silica and, leaching the silica from these particles to produce porous solid zirconia particles comprising a three dimensionally substantially continuous inter penetrating network of interconnected pores.

MATERIALS AND METHODS FOR MIXED MODE, ANION EXCHANGE REVERSED PHASE LIQUID CHROMATOGRAPHY

In various aspects, the present disclosure pertains to high purity chromatographic materials that comprise a chromatographic surface wherein the chromatographic surface comprises a hydrophobic modifier and an ionizable modifier comprising one or more anion exchange moieties that are positively charged when ionized, as well as devices containing such materials. In other aspects, the present disclosure provides methods for mixed mode, anion exchange reversed phase liquid chromatography comprising: (a) loading a sample comprising a plurality of acidic analytes (e.g., acidic glycans) onto a chromatographic separation device comprising such a high purity chromatographic material and (b) eluting adsorbed acidic analytes from the high purity chromatographic material with a mobile phase comprising water, organic solvent, and an organic acid salt, wherein during the course of elution a pH of the mobile phase, an ionic strength of the mobile phase, and a concentration of the organic solvent are altered over time. 1. A chromatographic material that comprises a chromatographic surface wherein the chromatographic surface comprises a hydrophobic modifier and an ionizable modifier comprising one or more anion exchange moieties , which are positively charged when ionized.2. The chromatographic material of claim 1 , wherein the high purity chromatographic material is hydrolytically stable over a pH range of about 3 to about 10.3. The chromatographic material of claim 1 , wherein the chromatographic material is an inorganic material claim 1 , a hybrid organic/inorganic material claim 1 , an inorganic material with a hybrid surface layer claim 1 , a hybrid material with an inorganic surface layer claim 1 , or a hybrid material with a different hybrid surface layer.4. (canceled)5. The chromatographic material of claim 1 , wherein the high purity chromatographic material comprises a hybrid organic/inorganic material that comprise ≡Si—(CH)—Si≡ moieties and/or (CH)CHmoieties claim 1 , ...

Chromatography processes using doped sol gel glasses as chromatographic media

Chromatography processes employ doped sol gel glasses as chromatographic media. In one embodiment, a process for qualitative or quantitative determination of a reactive chemical contained in a sample comprises passing the sample through a column or planar chromatography apparatus wherein the apparatus includes packing or plates containing a porous doped sol gel glass. The doped sol gel glass is formed form a metal alkoxide and contains a compound encapsulated therein which is reactive with the reactive chemical in the pores of the doped sol gel glass. In another embodiment, a process for analyzing a gas sample containing a reactive chemical comprises passing the gas sample through glass capillaries or tubes containing porous doped sol gel glass pellets. The pellets are formed from a metal alkoxide and contain a colorimetric reagent encapsulated therein which is reactive with the reactive chemical in the pores of the pellets. In a third embodiment, a doped sol gel glass is included in the ...

METHOD AND APPARATUS FOR CHROMATOGRAPHY USING SPHERICAL SILICA GEL

Sample is applied to a chromatographic column containing shape stabilized packing and the liquid phase is pumped through the shape stabilized packing at a rate of flow greater than the standard rate of flow to obtain at least one of a target resolution and target time of run. Because of the improved resolution provided by the shape stabilized packing at higher rates of flow of solvent, the chromatographer can either obtain better resolution with a standard gradient or shorten the time of the run and reduce the amount of solvent needed by increasing the slope of the gradient.

Microfluidic devices for liquid chromatography and mass spectrometry

In one aspect, a microfluidic device includes a substrate with a top surface and a raised channel architecture in which at least one channel is formed and defined across a top surface of the substrate and between raised side walls such that a floor of the channel is coplanar with the top surface. The device has a cover positioned over the substrate in alignment with the substrate and including a seal portion that is sealingly received between the raised side walls so as to seal the at least one channel. In addition, the device includes a column packing material disposed within the at least one channel between the raised side walls prior to sealing the at least one channel by merely only inserting the seal portion of the cover within the at least one channel between the raised side walls.

Improved chromatography resin, and methods and devices related thereto.

The invention relates to the field of analytical and preparative chemistry. Among others, it relates to an improved chromatographic resin and to means and methods involving use of the resin for the (on-line) clean up of complex test samples, such as biological samples. Provided is a chromatographic resin comprising a rigid polymer that is functionalized with at least one ligand capable of binding to a molecule of interest, wherein said ligand is covalently attached to the polymer via a small hydrophilic moiety based on a compound having 1-10 C-atoms and comprising a multiplicity of hydrophilic groups.

Selective purification of mono-terpenes for removal of oxygen containing species

ADSORPTION MEDIUM AND METHOD OF PREPARING SAME

An adsorption medium that includes a finely divided substrate provided on at least a portion of its surface with the polymerization product of a silane that includes (a) two or three olefinic groups having the formula -(CH2)mCH=CH2, where m is between 0 and 3, inclusive, and (b) at least one ligand selected to interact with a substance brought into contact with the adsorption medium to adsorb at least a portion of the substance on the surface of the adsorption medium.

Способ получения порошкообразной неподвижной фазы для высокоэффективной жидкостной хроматографии и установка для его реализации

Настоящее изобретение относится к области физико-химического и химического анализа, а именно, к способу получения порошкообразной неподвижной фазы для высокоэффективной жидкостной хроматографии, а также к установке для реализации такого способа. Способ заключается в том, что берут кварцевый песок, измельчают в аттриторе до размера 100 мкм, пропускают через высокочастотный индукционный разряд, смешивают с коллоидным раствором пирогенного оксида кремния в отношении 3/1, полученную смесь распыляют в печи при 1050°С и сушат в течение 4 часов, затем смесь повторно смешивают с коллоидным раствором пирогенного оксида кремния и повторно распыляют в печи и сушат, при этом процесс повторного смешивания и сушки повторяется до достижения размеров частиц не более 5 мкм. Установка для реализации указанного способа состоит из: аттритора с открываемым выходным отверстием на дне, при этом закреплённого в начале конвейерной ленты над ней; конвейерной ленты, проходящей под выходным отверстием аттритора, при ...

СПОСОБЫ ОПРЕДЕЛЕНИЯ МИНЕРАЛОГИИ КАЛЬЦИНИРОВАННОГО ДИАТОМИТА И ДИАТОМИТА, ПОДВЕРГАЕМОГО КАЛЬЦИНИРОВАНИЮ ПОД ФЛЮСОМ

Изобретение относится к области измерительной техники и может быть использовано для определения содержания опала-C и кристобалита продукта, который содержит диатомит. Способ может включать осуществление термической обработки для определения потерь на прокаливание для репрезентативной первой части образца продукта, идентификацию и количественное определение первичных и вторичных пиков, присутствующих на первой картине дифракции, которая получается в результате дифракции рентгеновского излучения в объеме порошка на репрезентативной второй части образца, и использование известного стандартного образца кристобалита для определения того, показывают ли первичные и вторичные пики, присутствующие на первой картине дифракции, присутствие опала-C или кристобалита в продукте. Технический результат – повышение точности и достоверности получаемых данных исследований. 16 з.п. ф-лы, 33 ил., 20 табл.

Verfahren zur säulenchromatographischen Trennung von Proteinen mittels Lipidbilayer-beschichteter Silicagele

Verfahren zur säulenchromatographischen Trennung von Proteinen, dadurch gekennzeichnet, daß ein Proteingemisch mit einem Chromatographiematerial in Kontakt gebracht wird, welches aus Silica besteht, dessen Dimensionen im Bereich Nanometer bis Mikrometer liegen und das mit einer nicht kovalent angebundenen Lipiddoppelschicht aus amphiphilen Lipiden umgeben ist, wobei die Lipiddoppelschicht aus einer Mischung von Lipiden besteht und wobei mindestens ein Lipid bei neutralem pH-Wert elektrisch neutral und mindestens ein Lipid bei neutralem pH-Wert geladen ist.

ADSORPTIONSMEDIUM UND VERFAHREN ZUR DESSEN HERSTELLUNG

VERFAHREN ZUR HERSTELLUNG VON PORÖSEN HYBRIDTEILCHEN MIT VON DER OBERFLÄCHE ENTFERNTEN ORGANISCHEN GRUPPEN

VERWENDUNG VON AMINEN, AMINOSÄUREN ODER AMINOSÄUREESTERN ALS MODIFIKATOREN DER MOBILEN PHASE BEI DER CHROMATOGRAPHIE

Superficially porous particles with precisely controlled particle density, and methods of preparation and use thereof

The invention relates superficially porous particles, wherein each particle comprises a hollow core, a non-porous inner shell, and a porous outer shell. The hollow core has a radius ranging from 20% to 90% of the radius of the entire particle, the particles have a median size range from about 0.5 μm to 100 μm, with a particle size distribution (one standard deviation) of no more than 15% of the median particle size, the particles have a specific surface area of from 5 to 1000 m2 /g, and the particles comprise a metal oxide selected from silica alumina, titania or zirconia. The particles may constitute a stationary phase in a separation device such as a chromatographic column. Further, a method for making these superficially porous particles is disclosed.

Siloxane-Immobilized particulate stationary phases for chromatographic separations and extractions

Device for performing separations and methods of making and using same

BIMODAL CHROMATOGRAPHIC RESOLVING ZONE

The powder for chromatographic separations is used in the separating zone of chromatographs. It essentially contains a multiplicity of separate porous macroparticles, each of which has a mean diameter of 0.5 to 500 mu m. The powder has a bimodal pore size distribution, the mean pore size for each distribution mode being such that the straight-line portions of the molecular weight calibration curve for each pore size in the bimodal distribution essentially do not intersect. Each distribution mode has a pore volume which is such that these straight-line portions run essentially parallel. At the same time, the mean pore sizes of the components of the bimodal distribution are separated by approximately an order of magnitude. The component of the bimodal distribution having the smaller mean pore size accounts for 30 to 60% of the total pore volume and the component of the bimodal distribution having the larger mean pore size accounts for 70 to 40% of it. The macroparticles are superficially ...

HIGH SPEEDLIQUID CHROMATOGRAPHY-PROCEED N AND DEVICE

MONOLITHIC MOLDED ARTICLES TO AUFREINIGUNG AND SEPARATION FROM BIO POLYMERS

PROCEDURE AND SYSTEM FOR THE SEPARATION AND AUFREINIGUNG AT LEAST A NARKOTI ALKALOID WITH USE OF PRÄPARATIVER REVERSAL PHASE CHROMATOGRAPHY

VERFAHREN ZUR REINIGUNG VON UTEROEVAKUIERENDE VERBIDUNGEN ENTHALTENDEN EXTRAKTEN DER ZOAPATL- -PFLANZE

PROCEDURE FOR THE PRODUCTION OF A COMPOUND SORPTION MATERIAL FOR THE CHROMATOGRAPHI SEPARATION FROM BIO POLYMERS

SELECTIVE CLEANING FROM MONOTERPEN TO THE DISTANCE OXYGEN OF CONTAINING COMPONENTS

USE OF AMINES, AMINO ACIDS OR AMINO ACID ESTERS AS MODIFIERS OF THE MOBILE PHASE WITH THE CHROMATOGRAPHY

PROCEDURE FOR THE CLEANING OF FROM THE ZOAPATL PLANT RECEIVED EXCERPTS

PROCEDURE FOR THE CLEANING OF UTEROEVAKUIERENDE VERBIDUNGEN CONTAINING EXCERPTS OF THE ZOAPATL - PLANT

SURFACE MODIFICATION OF KIESLSAÜRE AND THEIR PRODUCTS, IN PARTICULAR CHROMATOGRAPHY MEDIA

Methods for purifying radiolabelled compounds

METHODS FOR PURIFYING RADIOLABELLED COMPOUNDS

ISOLATION OF UTERO-EVACUANT SUBSTANCES FROM PLANT EXTRACTS

A method of chromatographic isolation for non-glyceride components

Derivatized potassium silicate supports

Systems and methods for radioisotope generation

Silica particles and methods of making and using the same

Mesoporous silicates and method of making same

ISOLATION OF UTERO-EVACUANT SUBSTANCES FROM PLANT EXTRACTS

ORTH 290 ISOLATION OF UTERO-EVACUANT SUBSTANCES FROM PLANT EXTRACTS A method of obtaining utero-evacuant substances from the zoapatle plant is described. The method involves acylation of semi-purified material obtained from a crude plant extract followed by physical separation of the biologically active materials.

METHODS FOR PURIFYING RADIOLABELLED COMPOUNDS

One aspect of the present invention relates to a method of purifying radiolabelled compounds comprising a) loading onto a fluorous polymer a radiolabelled compound precursor comprising a fluoroalkyl tin moiety; b) reacting the radiolabelled compound precursor with a radiolabel delivering compound to give a radiolabelled compound, wherein the fluoroalkyl tin moiety is replaced by a radiolabel; and c) eluting the radiolabelled compound from the fluorous polymer.

ISOLATION OF UTERO-EVACUANT SUBSTANCES FROM PLANT EXTRACTS

PROCESS FOR THE PURIFICATION OF GA-68 FROM ELUATE DERIVING FROM 68GE/68GA GENERATORS AND CHROMATOGRAPHIC COLUMNS FOR USE IN SAID PROCESS

Chromatography columns for the purification of eluates from 68Ge/68Ga generators comprising silica as stationary phase and purification processes that use said columns are described.

SYSTEMS AND METHODS FOR RADIOISOTOPE GENERATION

Systems and methods are disclosed for producing customized, predictable. and reproducible supplies of radioisotopes using, for example, a reactor housing that is fabricated from a radioactive shielding material and has both an internal volume and a surface that comprises an entry port and an exit port, a chromatographic column that is positioned within said internal volume such that a first end of said column is in fluid communication with said entry port and a second end of said column is in fluid communication with said exit port, and a changeable filter module that is disposed external to said reactor housing and in fluid communication with said exit port.

ORGANIC MODIFIED SILICIC ACID HETEROPOLYCONDENSATES

... 2045511 9008169 PCTABS00001 Organic modified silicic acid heteropolycondensates can be upgraded by removal of residual silanol or hydrolyzable groups. The upgrading process is conducted by contacting the condensate with a supercritical fluid at elevated temperature and pressure. Upgraded products in the form of powders can be dissolved in an organic solvent and used to produce coatings which have improved oxygen permeability. Upgraded products have also been made in non-comminuted, solid form such as rods. These articles are useful as adsorbents.

Core-shell silica and method for producing same

Disclosed is a core-shell silica having high sphericity and narrow particle size distribution. Also disclosed is a method for easily producing such a core-shell silica. Specifically disclosed is a method for producing a core-shell silica, which comprises a step for preparing a dispersion liquid by dispersing substantially non-porous silica core particles having a sphericity of not less than 0.8 and a coefficient of variation of not more than 0.2 into a dispersion medium composed of an alcohol and water in the presence of a surface active agent; a step for forming a shell precursor containing silica and the surface active agent on the surface of each silica core particle by adding a silica raw material into the dispersion liquid and causing a reaction of the silica raw material at a pH of 8-13; and a step for forming a porous shell by removing the surface active agent from the shell precursor.

Fluidic chip device

Silicon dioxide doped with aluminum containing particulate material

INSULATION OF SUBSTANCES EVACUATIVES OF THE UTERUS STARTING FROM EXTRACTS OF PLANTS

CELLULAR POROUS MONOLITHS CONDENSED TANNIN

Procédé de préparation de monolithes poreux polyHIPE, de type polyHIPE ou sous forme de mousse par durcissement de solutions de tannins condensés en présence d'huile, notamment d'huile végétale et/ou d'air et l'utilisation de ces matériaux.

METHOD OF CHROMATOGRAPHY ON A POROUS PACKING SHIP HATCH COVER

L'invention concerne un procédé de chromatographie, dans lequel on fait circuler une phase mobile gazeuse, liquide ou supercritique contenant des substances à séparer au travers d'un garnissage poreux comprenant une pluralité de conduits capillaires s'étendant dans la direction de circulation de ladite phase mobile, ledit garnissage étant fabriqué par un procédé dans lequel : - on assemble un faisceau de fibres élémentaires, lesdites fibres comprenant un cœur en un matériau solide, liquide ou gazeux, et une enveloppe en un matériau étirable, - on étire ledit faisceau de façon à réduire le diamètre desdites fibres, - on réalise une matrice poreuse autour du cœur des fibres étirées, la réalisation de ladite matrice poreuse comprenant une transformation du matériau d'enveloppe, - le cas échéant, on élimine le matériau de cœur de façon à laisser des conduits libres dans la matrice poreuse.

INSULATION OF SUBSTANCES Of UTERINE EVACUATION Of EXTRACTS OF PLANTS

THE SILICA MONOLITHIC PARTICLES, THE CHROMATOGRAPHIC STATIONARY PHASE COMPRISING THEM, AND THEIR MANUFACTURING METHOD

This invention is about silica monolithic particles, chromatographic stationary phases comprising them, and their manufacturing methods. The manufacturing process of silica monolithic particles of this invention includes three steps: the step for formation of bulk monolith (step 1) through sequential heating at three different temperatures, the step for powdering the silica monolith (step 2), and the step for calcination of the powdered silica monolith at 400-800oC (step 3). In this invention, the manufacturing process for silica monolith particles becomes much simpler by removing the sieving and washing steps in comparison with the previous methods, causing great reduction of production cost. In addition, silica monolith particles with reduced average particle size and increased average pore size are obtained in this invention. Thus the stationary phases comprising the silica monolith particles of this invention result in high separation performance in liquid chromatography.

PROCESSES FOR PRODUCTION OF SILICA GELS CARRYING DERIVATIZATION AGENTS FOR CARBONYL COMPOUNDS

The invention aims at providing a process for the production of silica gels carrying derivatization agents for carbonyl compounds which little suffers from the capture of carbonyl compounds during the production and thus makes it possible to give silica gel products exhibiting lowered blank values in the determination of carbonyl compounds; and silica gels carrying derivatization agents for carbonyl compounds which are produced by the process. The invention relates to a process for the production of silica gels carrying derivatization agents for carbonyl compounds, characterized by bringing a silica gel carrying an acid into contact with an organic solvent containing a derivatization agent for carbonyl compounds; packings consisting of silica gels carrying derivatization agents for carbonyl compounds, produced by the process; a process for the production of silica gels carrying derivatization agents for carbonyl compounds, characterized by pre-treating a silica gel bearing cation-exchange ...

THE SILICA MONOLITHIC PARTICLES, THE CHROMATOGRAPHIC STATIONARY PHASE COMPRISING THEM, AND THEIR MANUFACTURING METHOD

This invention is about silica monolithic particles, chromatographic stationary phases comprising them, and their manufacturing methods. The manufacturing process of silica monolithic particles of this invention includes three steps: the step for formation of bulk monolith (step 1) through sequential heating at three different temperatures, the step for powdering the silica monolith (step 2), and the step for calcination of the powdered silica monolith at 400-800oC (step 3). In this invention, the manufacturing process for silica monolith particles becomes much simpler by removing the sieving and washing steps in comparison with the previous methods, causing great reduction of production cost. In addition, silica monolith particles with reduced average particle size and increased average pore size are obtained in this invention. Thus the stationary phases comprising the silica monolith particles of this invention result in high separation performance in liquid chromatography.

MESOPOROUS INORGANIC OXIDE SPHERES AND METHOD OF MAKING SAME

A method of preparing mesoporous inorganic oxide spherical particles includes providing a reaction mixture capable of producing mesoporous inorganic oxide spheres; heating the reaction mixture to produce mesostructured inorganic oxide particles and removing organic material from the mesostructured inorganic oxide particles to form the mesoporous inorganic oxide spherical particles. In one embodiment a reaction mixture includes a proton donor, a source of inorganic oxide, and a source of fluoride. In another embodiment a reaction mixture includes a proton donor, a source of inorganic oxide, and an alcohol. Mesoporous inorganic oxide spheres produced by the method of the present invention are also provided.

WALLLESS MONOLITH COLUMNS FOR CHROMATOGRAPHY

A monolith column for chromatography including a monolith rod (20) encased with a tubular structure (10) wherein the mass of the interior surface layer of said tubular structure (10) intercalate by an encasing process into the surface layer of said monolith rod (20) through the micro-cavities of said surface layer of said monolith rod (20), forming a hybrid layer (11) shared by both said monolith rod (20) and said tubular structure (10).

Chromatographic materials for the separation of unsaturated molecules

The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group. In some examples, the present disclosure can include a chromatographic system having a chromatographic column having a stationary phase with a chromatographic substrate containing silica, metal oxide, an inorganic-organic hybrid material, a group of block copolymers, or a combination ...

Protein Chromatography Matrices with Hydrophilic Copolymer Coatings

A coating of a random copolymer of acrylamide and a second monomer, e.g. glycidoxylmethacrylate, for a silica surface is described. The coating is applied to chromatographic support structures having silica based surfaces. The coating is functionalized to produce protein chromatography matrices that are particularly useful for extracting trace amounts of biomarker molecules from biological samples.

SUPERFICIALLY POROUS PARTICLES AND METHODS FOR FORMING SUPERFICIALLY POROUS PARTICLES

Superficially porous particles are disclosed, each including a solid core and a layered porous shell. The layered porous shell includes a porous inner layer and at least one porous outer layer, a shell skeleton thickness greater than 1 nm, and constitutes from 10 vol % to 90 vol % of the plurality of superficially porous particles. The porous inner layer includes an inner layer thickness of less than 300 nm. The at least one porous outer layer includes a cumulative outer layer thickness ranging from 1 to 100 times the inner layer thickness, a predominately radial pore orientation, and an outer layer pore structure which is more organized than the inner layer pore structure. A layer-by-layer process for forming a plurality of superficially porous particles with layered structure is disclosed. A post-modification process for preparing a plurality of chromatographically enhanced superficially porous properties is also disclosed. 2. The plurality of superficially porous particles of claim 1 , wherein the at least one porous outer layer includes from 1 to 30 layers.3. The plurality of superficially porous particles of claim 1 , wherein the first inorganic oxide includes silica.4. The plurality of superficially porous particles of claim 1 , wherein the solid core includes a second inorganic oxide.5. The plurality of superficially porous particles of claim 4 , wherein first inorganic oxide is the same as the second inorganic oxide.6. The plurality of superficially porous particles of claim 1 , wherein the plurality of superficially porous particles includes a number average particle size ranging from 0.5 μm to 100 μm with a particle size distribution (one standard deviation) of less than 10% from average.7. The plurality of superficially porous particles of claim 1 , wherein the plurality of superficially porous particles includes an average pore size ranging from 4 nm to 100 nm.8. The plurality of superficially porous particles of claim 1 , wherein the plurality of ...

Method for recovering catalyst

A catalyst is recovered from an aqueous reaction mixture comprising heterocyclic nitroxyl catalyst and oxidized cellulose, by: —separating the oxidized cellulose from the reaction mixture, —contacting the reaction mixture with solid hydrophobic adsorbent particles with particle sizes below 350, preferably below 200 μm, more preferably below 100 μm, said particles being silica particles provided with functionalized hydrophobicity, —adsorbing the catalyst to the hydrophobic adsorbent particles, and —eluting the catalyst from the adsorbent particles with an organic solvent.

POROUS, MAGNETIC SILICA GEL MOLDED PARTS, PRODUCTION THEREOF, AND APPLICATION THEREOF

ПРОДУКТЫ ДИАТОМИТА

Способ получения тиосемикарбазон-силикагеля

Изобретение относится к получению сорбционных материалов на основе ковалентно модифицированных силикагелей. Предложен способ получения силикагеля, ковалентно модифицированного тиосемикарбазонными группами, путём взаимодействия силикагеля, содержащего ковалентно иммобилизованный фрагмент с альдегидной группой, и тиосемикарбазида в среде этанола при нагревании при 80°С в течение 1 ч в присутствии каталитического количества соляной кислоты. Технический результат – расширение ассортимента сорбционных материалов на основе силикагелей. 1 пр.

PACKUNG, VERWENDBAR FUER TRENNUNG.

Chip für die Nukleinsäuretrennung, strukturelles Element und Verfahren zu dessenBildung

Poröse, magnetische Kieselgelformkörper, deren Herstellung und Anwendung

Die vorliegende Erfindung betrifft poröse, magnetische Kieselgelformkörper mit neuen Eigenschaften, durch die Stofftrennungen aus Reaktionslösungen bzw. Festphasenreaktionen vereinfacht werden. Darüberhinaus wird ein Verfahren zur Herstellung dieser Trennmaterialien sowie deren mögliche Anwendungen beschrieben.

Superficially porous hybrid monoliths with ordered pores and methods of making and using same

Chromatographic material and methods for the synthesis thereof

A particulate material for chromatographic use comprising silica particles is provided having a skeleton structure containing silsesquioxane cage moieties. The material is useful as a chromatographic material, for example in HPLC. The silica particles may be hybrid organo-silica particles wherein the silsesquioxane moieties comprise a cage structure having silicon atoms positioned at corners of the cage wherein one or more silicon atoms positioned at the corners of the cagecarry an organic group. A preferred method of preparing the particulate material comprises hydrolysing a silsesquioxane as a co-component of a hydrolysis mixture, especially ina Stober or modified Stober process.

MULTICAPILLARY MONOLITH

The invention relates to a monolithic porous material made of amorphous silica or activated alumina, comprising substantially rectilinear capillary channels that are parallel to one another, wherein: 1. A monolithic porous material based on amorphous silica or activated alumina , comprising substantially rectilinear capillary channels parallel to one another , wherein:the channels have a substantially uniform cross-section relative to each other,the cross-section of each channel is regular over its entire length,the channels pass through the material from end to end,the length of the channels is equal to or more than 10 mm.2. The material of claim 1 , wherein the standard deviation of the diameter of the channels is less than 30% of the diameter claim 1 , preferably less than 5% thereof.3. The material claim 1 , having a relative volume of capillary channels that is less than 90%.4. The material of claim 1 , wherein the thickness of the wall between two adjacent channels claim 1 , in its narrowest part claim 1 , is less than one half of their diameter.5. The material of claim 1 , wherein the capillary channels have a diameter of between 0.1 and 1.5 micrometer.6. The material of claim 1 , wherein the capillary channels have a diameter greater than 50 μm.7. The material of claim 1 , formed of amorphous silica surface-modified by a silane.8. The material of claim 1 , based on an alumina γ claim 1 , χ claim 1 , κ claim 1 , η or θ.9. A chromatographic column whose packing comprises at least one monolithic porous material according to .10. An axial claim 1 , continuous annular chromatographic apparatus wherein the packing comprises at least one monolithic porous material according to .11. A radial claim 1 , continuous annular chromatographic apparatus wherein the packing comprises at least one monolithic porous material according to .12. A process for preparing a monolithic porous material based on amorphous silica or activated alumina comprising substantially rectilinear ...

Inorganic/Organic Hybrid Totally Porous Metal Oxide Particles, Methods For Making Them And Separation Devices Using Them

The present invention is a process for making an inorganic/organic hybrid totally porous spherical silica particles by self assembly of surfactants that serve as organic templates via pseudomorphic transformation. 122-. (canceled)24. The totally porous particles of claim 23 , wherein the totally porous particles exhibit at least one X-ray diffraction peak between 0.01° and 10° of the 2θ scan range.25. The totally porous particles of claim 23 , wherein M is Si.26. The totally porous particles of claim 23 , wherein Ris independently selected in each instance from methyl or ethyl and Ris selected from methylene claim 23 , ethylene or 1 claim 23 ,2-benzylene.27. (canceled)28. (canceled)29. The totally porous particles of claim 23 , wherein the totally porous particles are created by reacting silica claim 23 , titania or zirconia particles with an organic metal alkoxide.30. The totally porous particles of claim 23 , wherein the median size of the totally porous particles is from about 0.5 μm to about 10 μm.31. The totally porous particles of claim 23 , wherein the pore size ranges from about 60 Å to about 800 Å.32. The totally porous particles of claim 23 , wherein the specific surface area of the totally porous particles is from about 5 m/g to about 300 m/g.33. (canceled)34. (canceled)36. The totally porous particles of claim 35 , wherein the totally porous particles are created by reacting alumina particles with an organic metal alkoxide.37. The totally porous particles of claim 35 , wherein the median size of the totally porous particles is from about 0.5 μm to about 10 μm.38. The totally porous particles of claim 35 , wherein the pore size ranges from about 60 Å to about 800 Å.39. The totally porous particles of claim 35 , wherein the specific surface area of the totally porous particles is from about 5 m/g to about 300 m/g.40. (canceled)41. (canceled)43. Totally porous particles claim 35 , comprising: [{'br': None, 'sub': 2', '3', 'x', 'y, 'sup': 1', '1, 'AlO/(RAlO ...

Carbon Composite Materials for Separations

A composite particulate material useful in analytical separations processes includes a carbon coating deposited through chemical vapor deposition on a substantially metal-free inorganic oxide particle. The resultant laminate material may be tuned for desired sorption rates and selectivities with respect to analytes of interest. 1. A composite particulate material for use as a sorption media in high-pressure liquid chromatography , said composite particulate material comprising a pyrolytic carbon coating deposited on an inorganic oxide particle , wherein said composite matriculate material is substantially metal-free.2. A composite particulate material as in wherein said inorganic oxide particle is Type B silica.3. A composite particulate material as in wherein said inorganic oxide particle has a maximum cross-sectional dimension of 50 micrometers.4. A composite particulate material as in comprising 1-50 weight % carbon.5. A composite particulate material as in wherein said inorganic oxide particle is porous claim 1 , with a mean pore diameter of 10-500 angstroms.6. A composite particulate material as in which is free from exposed silanol groups.7. A composite particulate material as in wherein said inorganic oxide particle has a surface area of at least 10 m/g.8. A composite particulate material as in wherein said carbon coating covers between 5-70% of said surface area of said particle.9. A method for producing a sorption media for high-pressure liquid chromatography claim 7 , said method comprising:(a) loading a reactor with particulate material;(b) elevating a reactor temperature to at least 500° C. and a reactor pressure to greater than 760 mm Hg;(c) providing a carbon source that is thermostatted to a source temperature of at least 25° C.; and(d) introducing to said heated reactor a vapor from said carbon source to deposit a coating of carbon on said particulate material, the coated particulate material forming a composite.10. A method as in wherein said ...

SUPERFICIALLY POROUS MATERIALS COMPRISING A SUBSTANTIALLY NONPOROUS HYBRID CORE HAVING NARROW PARTICLE SIZE DISTRIBUTION; PROCESS FOR THE PREPARATION THEREOF; AND USE THEREOF FOR CHROMATOGRAPHIC SEPARATIONS

The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are chromatographic materials comprising having a narrow particle size distribution. 1. A superficially porous material comprising a substantially nonporous inorganic/organic hybrid core and one or more layers of a porous shell material surrounding the core.2. The superficially porous material of claim 1 , wherein the material is comprised of superficially porous particles.3. The superficially porous material of claim 1 , wherein the material is a superficially porous monolith.4. The superficially porous material of claim 2 , wherein the material has a substantially narrow particle size distribution.5. The superficially porous material of claim 2 , wherein the core has a substantially narrow particle size distribution.6. The superficially porous material of claim 2 , wherein the 90/10 ratio of particle sizes is from 1.00-1.55 claim 2 , from 1.00-1.10 claim 2 , from 1.05-1.10 claim 2 , from 1.10-1.55 claim 2 , from 1.10-1.50 or from 1.30-1.45.711-. (canceled)12. The superficially porous material of claim 1 , wherein the material has chromatographically enhancing pore geometry.13. The superficially porous material of claim 12 , wherein the material has a small population of micropores.19. The superficially porous material of wherein the porous shell material is a porous inorganic/organic hybrid material.20. The superficially porous material of wherein the porous shell material is a porous silica.21. The superficially porous material of wherein the porous shell material is a porous composite material.22. The superficially porous material of comprising more than one layer of porous shell material wherein each layer ...

Device and method for enhanced collection and assay of chemicals with high surface area ceramic

A method and device for enhanced capture of target analytes is disclosed. This invention relates to collection of chemicals for separations and analysis. More specifically, this invention relates to a solid phase microextraction (SPME) device having better capability for chemical collection and analysis. This includes better physical stability, capacity for chemical collection, flexible surface chemistry and high affinity for target analyte.

COMPOSITE ADSORBENT MATERIAL

Disclosed is a composite adsorbent material comprising three components, including a porous media, a hygroscopic material, and graphite flakes. Among the many different possibility considered, it may be advantageous for the porous media to be mesoporous silica or the hygroscopic materials to be calcium chloride, lithium bromide, or lithium chloride. It is considered that the graphite flakes may comprise 50 percent or less of the graphite flake-hygroscopic material composition, and certain embodiments may utilize between 15 and 30 percent graphite in the graphite flake-hygroscopic material composition. It is still further considered that the graphite flakes may advantageously be less than 300 microns in size, or may have an average number of carbon planes that is 100 or less. Additional materials may also be incorporated, including biologics, polymers, and catalysts. 1. A adsorbent system comprising:a porous media;a hygroscopic material; anda plurality of graphite flakes.2. The adsorbent system according to claim 1 , wherein the porous media is mesoporous silica.3. The adsorbent system according to claim 1 , wherein the hygroscopic materials is selected from the group consisting of calcium chloride claim 1 , lithium bromide claim 1 , or lithium chloride.4. The adsorbent system according to claim 1 , wherein the graphite flakes comprise 50 percent or less of the total combined weight.5. The adsorbent system according to claim 4 , wherein the graphite flakes comprise between 5 and 30 percent of the combined weight of the graphite flakes and hygroscopic material.6. The adsorbent system according to claim 1 , wherein the graphite flakes are less than 300 microns in size.7. The adsorbent system according to claim 1 , wherein the average number of layers of carbon planes in the graphite flakes is less than or equal to 100.8. The adsorbent system according to claim 1 , further comprising at least one additional material.9. The adsorbent system according to claim 8 , wherein ...

PROCESS FOR THE PURIFICATION OF GA-68 FROM ELUATE DERIVING FROM 68GE/68GA GENERATORS AND CHROMATOGRAPHIC COLUMNS FOR USE IN SAID PROCESS

Chromatography columns for the purification of eluates from Ge/Ga generators comprising silica as stationary phase and purification processes that use said columns are described. 110-. (canceled)11. Process for the preparation of a radiopharmaceutical containing Ga-68 wherein a solution of eluates from 68Ge/68Ga generators is passed through a column for chromatography purification comprising a stationary phase of silica having a granulometry inferior to 100 micron and thereafter said solution is directly poured in a container containing the labeling kit.12. Process according to wherein:{'sup': 68', '68, 'a chromatography column for purifying 68Ga from 68Ge comprising a stationary phase made of silica having a granulometry inferior to 100 micron is placed in line at the exit of a Ga/Ga generator;'}the solution from the generator is passed though the column;the purified solution containing 68Ga collected from the column is directly added into a container containing the labeling kit.13. A radiopharmaceutical kit comprising the radioactive isotope Ga produced through the process according to .14. A radiopharmaceutical kit comprising the radioactive isotope Ga produced through the process according to . The present invention relates to the purification processes of radioactive isotopes, in particular the purification of eluates containing Ga-68 deriving from Ge/Ga generators.As is known, radioactive isotopes are widely used in medicine both for diagnostic purposes and for therapeutic purposes; in particular, radioactive isotopes of a metallic nature are bonded, by means of appropriate chelating agents, to carrier molecules (such as peptides) capable of recognizing and interacting (both in vivo and in vitro) with specific cell receptors so as to allow the detection and/or the destruction of diseased cells.This labeling strategy is well suited to the production of kits containing the carrier molecule/chelating agent complex plus any reagents necessary to allow the ...

GUARD COLUMN AND METHOD FOR PRODUCING GUARD COLUMN

Provided is a guard column including a filling part having a length of 2.0 cm to 3.5 cm formed of a filler, in which the filler is made of porous silica gel having a hydrophilized surface and an average particle size of 1.5 μm to 2.5 μm, and a pressure difference when an aqueous solution is fed at a linear flow rate of 2.1 cm/min is 4.0 MPa or more. 1. A guard column , comprisinga filling part having a length of 2.0 cm to 3.5 cm formed of a filler, whereinthe filler includes porous silica gel having a hydrophilized surface and an average particle size of 1.5 μm to 2.5 μm, anda pressure difference when an aqueous solution is fed at a linear flow rate of 2.1 cm/min is 4.0 MPa or more.2. The guard column according to claim 1 , wherein the porous silica gel has an average pore size of 25 nm to 35 nm and a specific surface area of 100 m/g to 300 m/g.3. The guard column according to claim 1 , the column is used for size-exclusion chromatography in which a column using the filler containing porous silica gel and a light scattering detector are used.4. A liquid chromatograph comprising the guard column according to claim 1 , a size-exclusion chromatography column filled with a filler containing porous silica gel claim 1 , and a light scattering detector in this order from an upstream side.5. A method of analyzing a polymer compound claim 1 , which comprises:{'claim-ref': {'@idref': 'CLM-00004', 'claim 4'}, 'analyzing a polymer compound with size-exclusion chromatography using the liquid chromatograph according to .'}6. A method for producing a guard column according to claim 1 , comprising:a step of filling a filler including porous silica gel having a hydrophilized surface and an average particle size of 1.5 μm to 2.5 μm at a filling pressure of 12 MPa to 40 MPa per 1 cm in length to form a filling part having a length of 2.0 cm to 3.5 cm.7. The guard column according to claim 1 , wherein a diameter of the filling part is 0.4 cm to 0.9 cm.8. The guard column according to ...

METHOD OF CHROMATOGRAPHY ON A POROUS PACKING PRODUCED BY A DRAWING PROCESS

The invention relates to a method of chromatography wherein a gaseous, liquid or supercritical fluid mobile phase, which contains substances to be separated, flows through a porous packing which comprises a plurality of capillary channels which extend in the direction of flow of said mobile phase, 1. A chromatography method wherein a gaseous , liquid or supercritical fluid mobile phase , containing substances to be separated , flows through a porous packing which comprises a plurality of capillary channels which extend in the direction of flow of the mobile phase , a bundle of elementary fibres is assembled, said fibres comprising a core made of a solid, liquid or gaseous material, and a shell made of a drawable material,', 'said bundle is drawn in order to reduce the diameter of the fibres,', 'a porous matrix is made around the core of the drawn fibres, the manufacture of said porous matrix comprising transformation of the shell material, said porous material comprising at least one population of connected pores interconnecting the channels, where the thickness of the porous matrix between two adjacent channels is less than the diameter of the channels, preferably less than half the diameter of the channels,', 'where necessary the core material is removed so as to leave free channels in the porous matrix., 'wherein the packing is manufactured by a method wherein2. The method according to claim 1 , wherein the pores have a diameter greater than twice the molecular diameter of the substances to be separated.3. The method according to claim 1 , wherein the mean diameter of the channels is less than 30 μm claim 1 , and preferably less than 10 μm.4. that the method according to claim 1 , wherein the mobile phase is a gas phase and in that the population of connected pores interconnecting the channels has a mean diameter greater than the mean free path of the species to be separated in the mobile phase.5. that the method according to claim 1 , wherein the bundle is drawn ...

Biocompatible Solid-Phase Microextraction Coatings and Methods for their Preparation

A biocompatible coating, such as for a fiber, for solid phase microextraction (SPME) of a small molecule of interest from a matrix, with the coating having an extraction phase including SPME particles having pores dimensioned to absorb the small molecule of interest from the matrix and a biocompatible polymer being a polyacrylonitrile (PAN) or a co-polymer of polyacrylonitrile (PAN) that completely covers the SPME particles and homogeneously distributing the SPME particles therein and having reduced adsorption of proteins or macromolecules onto the SPME particles and allowing the SPME particles to extract the small molecule of interest from the matrix.

SUPERFICIALLY POROUS MATERIALS COMPRISING A COATED CORE HAVING NARROW PARTICLE SIZE DISTRIBUTION; PROCESS FOR THE PREPARATION THEREOF; AND USE THEREOF FOR CHROMATOGRAPHIC SEPARATIONS

The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are chromatographic materials comprising having a narrow particle size distribution. 1. A superficially porous material comprising a coated core and one or more layers of a porous shell material surrounding the coated core , wherein said coated core comprises a substantially nonporous core material coated with a core-coating material.2. The superficially porous material of claim 1 , wherein the material is comprised of superficially porous particles.3. The superficially porous material of claim 1 , wherein the material is a superficially porous monolith.4. The superficially porous material of claim 2 , wherein the material has a substantially narrow particle size distribution.5. The superficially porous material of claim 2 , wherein the substantially nonporous core material has a substantially narrow particle size distribution.6. The superficially porous material of claim 2 , wherein the 90/10 ratio of particle sizes is from 1.00-1.55.7. The superficially porous material of claim 6 , wherein the 90/10 ratio of particle sizes is from 1.00-1.10.8. The superficially porous material of claim 7 , wherein the 90/10 ratio of particle sizes is from 1.05-1.10.9. The superficially porous material of claim 6 , wherein the 90/10 ratio of particle sizes is from 1.10-1.55.10. The superficially porous material of claim 9 , wherein the 90/10 ratio of particle sizes is from 1.10-1.50.11. The superficially porous material of claim 10 , wherein the 90/10 ratio of particle sizes is from 1.30-1.45.12. The superficially porous material of claim 1 , wherein the material has chromatographically enhancing pore geometry.13. The ...

CHROMATOGRAPHIC MATERIALS FOR THE SEPARATION OF UNSATURATED MOLECULES

The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group. In some examples, the present disclosure can include a chromatographic system having a chromatographic column having a stationary phase with a chromatographic substrate containing silica, metal oxide, an inorganic-organic hybrid material, a group of block copolymers, or a combination thereof. 2. The stationary phase of claim 1 , wherein the surface of X is subject to alkoxylation by a chromatographic mobile phase under chromatographic conditions.3. The stationary phase of claim 2 , wherein a substantial portion of the surface of X does not undergo alkoxylation by a chromatographic mobile phase under chromatographic conditions.4. The stationary phase of claim 1 , wherein the surface of X does not comprise silica claim 1 , and b=0 or c=0.5. The stationary phase of claim 1 , wherein the chromatographic stationary phase is adapted for supercritical fluid chromatography.6. The stationary phase of claim 1 , wherein the chromatographic stationary phase is adapted for carbon dioxide based chromatography.7. A column claim 1 , capillary column claim 1 , microfluidic device or apparatus for normal phase chromatography claim 1 , high-pressure liquid chromatography claim 1 , solvated gas chromatography claim 1 , supercritical fluid chromatography claim 1 , sub-critical fluid ...

Systems and Methods for Separating Radium from Lead, Bismuth, and Thorium

Systems for separating Ra from a mixture comprising at least Ra, Pb, Bi, and Th are provided. The systems can include: a first vessel housing a first media and Th or Bi; a second vessel in fluid communication with the first vessel, the second vessel housing a second media and Pb; and a third vessel in fluid communication with the second vessel, the third vessel housing a third media and Ra, wherein at least one of the first, second, or third medias are different from the other media. 1. A system for separating Ra from a mixture comprising at least Ra , Pb , Bi , and Th , the system comprising:a first vessel housing a first media and either Pb or Bi and/or Th; anda second vessel in fluid communication with the first vessel, the second vessel housing a second media and Ra, wherein the first media is different from the second media.2. The system of wherein the first media is associated with Bi and/or Th and comprises a quaternary amine on a polystyrene divinylbenzene copolymer.3. The system of wherein the second media is associated with Ra and comprises a silica support.4. The system of wherein the first media is associated with Pb and comprises 18-crown-6 and 1-octanol on Amberchrom CG-71 polymer support.5. The system of wherein the second media is associated with Ra comprises a on silica support.6. The system of wherein the first media size is less than 100 μm.7. The system of wherein the second media size is greater than 100 μm.8. A system for separating Ra from a mixture comprising at least Ra claim 1 , Pb claim 1 , Bi claim 1 , and Th claim 1 , the system comprising:a first vessel housing a first media and Th and/or Bi; anda second vessel in fluid communication with the first vessel, the second vessel housing a first media and Pb, wherein the first media is different from the second media.9. The system of wherein the first vessel is in fluid communication with raw material supply.10. The system of wherein the first vessel is in fluid communication with a wash ...

APPLICATION OF MACROPOROUS SILICA SYNTHESIZED BY A SALT-TEMPLATED AEROSOL METHOD FOR CHROMATOGRAPHY

The present invention discloses a silica particle having a diameter less than or equal to 2 μη, wherein the particle is spherical and comprises interconnected pores having a diameter in the range from 50 nm to 300 nm. The silica particle is preferably produced by spray pyrolysis (=spray drying) of a silica colloid. In the production process, porosity is introduced by means of an inorganic salt, such as NaCl, KCI, LiCl, NaNO3 or Ll NO3, which serves as a pore template. The silica particle may further be functionalized with proteins, peptides, nucleic acids, polysaccharides and proteoglycans, preferably concanavalin A or avidin. The present invention further discloses the use of the silica particle in chromatography, in particular in affinity chromatography. 1. A silica particle having a diameter less than or equal to about 2 μm , wherein the particle is spherical and comprises interconnected pores having a diameter in the range from about 50 nm to about 300 nm.2. The silica particle of claim 1 , wherein the silica particle provides a support with a surface area of about 150 m/g to about 300 m/g.3. The silica particle of claim 1 , wherein the silica particle is functionalized with a stationary phase.4. The silica particle of claim 3 , wherein the stationary phase is selected from the group consisting of proteins claim 3 , peptides claim 3 , nucleic acids claim 3 , polysaccharides claim 3 , and proteoglycans.5. The silica particle of claim 4 , wherein the proteins are concanavalin A or avidin.6. The silica particle of claim 1 , wherein the silica particle is synthesized by spray pyrolysis of silica colloids.7. The silica particle of claim 6 , wherein porosity is introduced into the particle by means of an inorganic salt acting as a pore template.8. The silica particle of claim 7 , wherein the inorganic salt is selected from the group consisting of NaCl claim 7 , KCl claim 7 , LiCl claim 7 , NaNO claim 7 , LiNO claim 7 , combinations thereof claim 7 , and mixtures ...

Porous Media Compositions and Methods for Producing the Same

The present invention relates to porous substrate compositions and methods for producing such compositions. In one embodiment, the porous substrate composition of the present invention comprises sintered spherical particles of a substantially uniform size. The porous media compositions of the present invention comprise relatively randomly-ordered particles with a void fraction significantly higher than compositions with a more ordered, close-packed configuration. The present invention further relates to composite porous media compositions comprising two or more relatively discrete layers of sintered particles. 1. A sintered porous material , comprising:one or more layers of sintered particles having a void fraction of at least about 0.26,wherein each layer comprises substantially spherical particles having a relative standard deviation in particle size of about 10 percent or less.2. The material of claim 1 , wherein the sintered particles comprise:a substantially solid core, andone or more shell layers, wherein each shell layer comprises a plurality of sintered shell particles.3. The material of claim 1 , comprising a first layer and a second layer claim 1 , wherein the second layer comprises substantially spherical particles having a relative standard deviation in particle size of about 10 percent or less claim 1 , and the second layer is sintered to the first layer.4. The material of claim 1 , wherein the average particle size of the particles is greater than about 1 micron.5. The material of claim 1 , wherein the average particle size of the particles is about 1.7 micron.6. The material of claim 1 , wherein the average particle size of the particles is greater than about 3 micron.7. The material of claim 1 , wherein the average particle size of the particles is less than about 500 nm.8. The material of claim 1 , wherein the average particle size of the particles is less than about 250 nm.9. The material of claim 1 , wherein the average particle size of the ...

System for radiopharmaceutical production

Certain embodiments of the present invention relate to a system and a method for producing a radiopharmaceutical, wherein the system is formed from and/or provides a microfluidic flow system. In certain embodiments, the system comprises a radioisotope isolation module, a radiopharmaceutical production module, a purification module and a quality control module.

System and method for sorbtion distillation

A system for distilling water is disclosed. The system comprises a heat source, and a plurality of open-cycle adsorption stages, each stage comprising a plurality of beds and an evaporator and a condenser between a first bed and a second bed, wherein each bed comprises at least two vapor valves, a plurality of hollow tubes, a plurality of channels adapted for transferring water vapor to and from at least one of the condenser or the evaporator, a thermally conductive water vapor adsorbent, and wherein each vapor valve connects a bed to either the condenser or the evaporator.

CHROMATOGRAPHIC COMPOSITIONS

Provided herein are stationary phase compositions comprising a chromatographic surface of porous or non-porous core material comprising a surface modifier for use in chromatographic separations. 5. The stationary phase composition of claim 4 , wherein Ris trimethylsilyl.11. The stationary phase composition of claim 10 , wherein Ris trimethylsilyl.12. The stationary phase composition of claim 1 , wherein each b is 0 to 3.13. The stationary phase composition of claim 1 , wherein each b is 0.14. The stationary phase composition of claim 1 , wherein each a is 0 to 3.15. The stationary phase composition of claim 1 , wherein each a is 0.16. The stationary phase composition of claim 1 , wherein each x is 0 to 4.17. The stationary phase composition of claim 1 , wherein each x is 0.18. The stationary phase composition of claim 1 , wherein each y is 0 to 4.19. The stationary phase composition of claim 1 , wherein each y is 0.20. The stationary phase composition of claim 1 , wherein each Rand Rare independently aryl or (C-C)alkyl optionally substituted with cyano. This application is a continuation of U.S. application Ser. No. 15/921,811 entitled “Chromatographic Compositions” filed Mar. 15, 2018, which claims benefit of and priority to U.S. Provisional Application Nos. 62/472,342 entitled “Chromatographic Compositions” filed Mar. 16, 2017, and 62/543,654 entitled “Chromatographic Compositions” filed Aug. 10, 2017, the contents of each of which are incorporated herein by reference in their entirety.The technology relates generally to chromatographic compositions. The invention relates more particularly, in various embodiments, to stationary phase compositions comprising a chromatographic surface of porous or non-porous core material comprising a surface modifier for use in chromatographic separations.Liquid chromatography (LC) combined with mass spectrometry (MS) is one of the most powerful analytical tools for the characterization of proteins. Indeed, for the analysis of ...

Temperature-responsive monolithic porous body, method for producing same, and temperature-responsive chromatography method using same

A temperature responsive monolithic porous material is obtained that comprises a polymer having a hydration ability that changes in a temperature range of 0 to 80° C. and being immobilized to a surface of the porous material at a high density by binding an atom transfer radical polymerization initiator to a surface of the porous material, and inducing a growth reaction of a polymer, having a hydration ability that changes in a temperature range of 0 to 80° C., from the initiator using an atom transfer radical process under a presence of a catalyst.

Opaline flux-calcined diatomite products

A diatomite product and method of using such is disclosed. The diatomite product may comprise sodium flux-calcined diatomite, wherein the diatomite product has a crystalline silica content of less than about 1 wt %, and the diatomite product has a permeability between 0.8 darcy and about 30 darcy. In some embodiments, the diatomite product may be in particulate or powdered form. This disclosure also concerns flux-calcined silica products containing low or non-detectable levels of crystalline silica. Some of these products can be further characterized by high permeabilities and a measurable content of opal-C, a hydrated form of silicon dioxide.

Mesoporous silica and organosilica materials and process for their preparation

In this invention, we disclose a method as well as silica and/or organosilica mesoporous materials obtained by templating using nanocrystalline cellulose and removal of the latter using acidic conditions. The resultant mesoporous silica materials are characterized by having high surface area with tunable iridescence resulting from the long-range chiral nematic organization. This invention is an improvement over the formation of composite materials formed with nanocrystalline cellulose (NCC) and silica, where the calcination of the materials led to removal of the cellulose and formation of a mesoporous silica material. Characteristically, the removal of the NCC template using acidic conditions differentiates the silica materials thus obtained in two ways: (1) It does not lead to as significant contraction of the materials as from calcination thereby giving access to materials with larger mesopores; and (2) it allows the formation of mesoporous chiral nematic compositions that include heat-sensitive components. This approach may be used to prepare the first example of a mesoporous organosilica material with a chiral nematic pore structure. Examples of possible applications of this material include optical filters, adsorbents, chiral stationary phases for chromatography, sensors, composite materials, membranes, and templates for creating other chiral materials.

CHROMATOGRAPHY COLUMN WITH LOCKED PACKED BED AND METHOD OF PACKING THAT COLUMN

A chromatography column has a retaining plug permanently fixed to an upstream end of the column and blocks one end of the bore through the column. The plug has a fluid passage therethrough. An upstream end of the passage is preferably but optionally larger in diameter than a downstream end of the passage. An upstream porous member upstream of the retaining plug is held by an upstream end cap and urged toward the plug. Chromatographic media extends from the upstream porous member, through the passage in the retaining plug, to a downstream porous member held by a downstream end cap. The media between the retaining plug and the downstream porous member are under compression to form a bed of packed media. 1. A chromatography column having a tubular body with opposing upstream and downstream ends with upstream and downstream end fittings connected to the tubular body , the tubular body having an internal bore extending along a longitudinal axis of the tubular body and column , the column comprising:a retaining plug blocking an upstream end of the bore and having a passage extending between upstream and downstream ends of the retaining plug and filled with chromatographic media;a downstream porous member blocking the downstream end of the bore, the bore having a continuous wall between the retaining plug and the downstream porous member;a slurry-packed bed of chromatographic media held in compression in the bore by the retaining plug and the downstream porous member;2. The column of claim 1 , wherein the passage contains porous media and further comprising an upstream porous member upstream of the retaining plug located to filter fluid flow through the bore into the at least one passage.3. The column of claim 2 , wherein the passage has a first diameter at the upstream end of the retaining plug and a second diameter at the downstream end of the retaining plug and the first diameter is larger than the second diameter.4. The column of claim 3 , wherein the first diameter is ...

SIZE EXCLUSION CHROMATOGRAPHY UTILIZING LOW CONCENTRATION AMINO ACIDS IN SIZE EXCLUSION CHROMATOGRAPHY MOBILE PHASE

The present disclosure is directed to methods for performing size exclusion chromatography. Embodiments of the present disclosure feature methods for improving separations of proteinaceous analytes in size exclusion chromatography, for example, by using low concentrations of amino acids or derivatives thereof in the mobile phase. 1. A method for performing size exclusion chromatography on a sample containing at least one analyte , the method comprising:{'sup': '2', 'a. contacting said sample with a column chromatography device comprising a column having an interior for accepting a stationary phase, and an immobilized stationary phase within said interior of the column, wherein the immobilized stationary phase comprises porous particles having a surface and a diameter with a mean size distribution of between about 1 and about 20 μm; an average pore size from about 40 to about 3000 Å; and wherein said porous particles are surface modified with a hydroxy-terminated polyethylene glycol at a surface concentration from about 0.5 to about 5.0 μmoles/m;'}b. flowing a mobile phase through the immobilized stationary phase for a period of time, the mobile phase comprising water; a buffer; and an amino acid or derivative thereof, wherein the amino acid or derivative thereof is present in the mobile phase at a concentration from about 5 to about 40 mM; andc. eluting the at least one analyte from the immobilized stationary phase in the mobile phase.2. The method of claim 1 , wherein eluting comprises separating the sample into one or more analytes on the basis of decreasing hydrodynamic radius of said one or more analytes.3. The method of claim 1 , wherein the amino acid or derivative thereof is present in the mobile phase at a concentration from about 5 to about 20 mM.4. (canceled)5. The method of claim 1 , wherein the amino acid is selected from the group consisting of L-arginine claim 1 , L-ornithine claim 1 , and L-lysine.6. The method of claim 1 , wherein the amino acid ...

TEMPERATURE-RESPONSIVE MONOLITHIC POROUS BODY, METHOD FOR PRODUCING SAME, AND TEMPERATURE-RESPONSIVE CHROMATOGRAPHY METHOD USING SAME

A temperature responsive monolithic porous material is obtained that comprises a polymer having a hydration ability that changes in a temperature range of 0 to 80° C. and being immobilized to a surface of the porous material at a high density by binding an atom transfer radical polymerization initiator to a surface of the porous material, and inducing a growth reaction of a polymer, having a hydration ability that changes in a temperature range of 0 to 80° C., from the initiator using an atom transfer radical process under a presence of a catalyst. 1. A temperature responsive monolithic porous material comprising a polymer having a hydration ability that changes in a temperature range of 0 to 80° C. and being bound to a surface of the porous material at a density of 0.01 molecular chain/nmor higher.2. The temperature responsive monolithic porous material of claim 1 , wherein the porous material consists of silica.3. The temperature responsive monolithic porous material according to claim 1 , wherein an amount of bound-polymer on the surface of the porous material is 0.2 to 10.0 mg/m.4. The temperature responsive monolithic porous material according to claim 1 , wherein a polymer molecular chain is non-crosslinked.5. The temperature responsive monolithic porous material according to claim 1 , wherein the polymer is one or a plurality of poly-N-substituted acrylamide derivative claim 1 , poly-N-substituted methacrylamide derivative claim 1 , their copolymer claim 1 , polyvinylmethyl ether claim 1 , a partially acetylated polyvinyl alcohol.6. The temperature responsive monolithic porous material according to claim 1 , wherein the polymer is poly-N-isopropylacrylamide.7. The temperature responsive monolithic porous material according to claim 5 , wherein the polymer is a copolymer containing a hydrophilic molecule claim 5 , a hydrophobic molecule and an ionic molecule in a polymer molecular chain claim 5 , at a range that retains a feature of the hydration ability to ...

Manufacturing method for core-shell-type porous silica particle

Provided is a method for manufacturing core-shell-type porous silica particles, the method including: a preparation step for preparing an aqueous solution containing non-porous silica particles, a cationic surfactant, a basic catalyst, a hydrophobic part-containing additive, and an alcohol; a shell precursor formation step for adding a silica source to the aqueous solution to form a shell precursor on the surfaces of the non-porous silica particles; and a shell formation step for removing the hydrophobic part-containing additive and the cationic surfactant from the shell precursor to form a porous shell.

HYBRID MATERIAL FOR CHROMATOGRAPHIC SEPARATIONS COMPRISING A SUPERFICIALLY POROUS CORE AND A SURROUNDING MATERIAL

The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for their preparation and separations devices containing the chromatographic materials. The preparation of the inorganic/organic hybrid materials of the invention wherein a surrounding material is condensed on a superficially porous hybrid core material will allow for families of different hybrid packing materials to be prepared from a single core hybrid material. Differences in hydrophobicity, ion-exchange capacity, chemical stability, surface charge or silanol activity of the surrounding material may be used for unique chromatographic separations of small molecules, carbohydrates, antibodies, whole proteins, peptides, and/or DNA. 1. An inorganic/organic hybrid material comprising an inorganic/organic hybrid surrounding material and a superficially porous core.2. The inorganic/organic hybrid material of claim 1 , wherein the inorganic/organic hybrid surrounding material and the superficially porous core are composed of different materials.3. The inorganic/organic hybrid material of claim 1 , wherein the inorganic/organic hybrid surrounding material and the superficially porous core are composed of the same materials.4. The inorganic/organic hybrid material of claim 1 , wherein the inorganic/organic hybrid surrounding material is composed of a material which enhances one or more of the characteristics selected from the group consisting of chromatographic selectivity claim 1 , particle chemical stability claim 1 , column efficiency claim 1 , and mechanical strength.5. The inorganic/organic hybrid material of claim 1 , wherein the superficially porous core is composed of a material which enhances one or more characteristics selected from the group consisting of chromatographic selectivity claim 1 , particle chemical stability claim 1 , column efficiency claim 1 , and mechanical strength.6. The inorganic/organic hybrid material of claim 4 , wherein the ...

Modified cotton fabric for solid-phase extraction and fabrication method

A method for solid-phase extraction is disclosed. The method includes fabricating a solid-phase extraction medium by incorporating a plurality of modified mesoporous silica particles within pores of a cotton fabric matrix, putting the solid-phase extraction medium in contact with a fluid containing metal ions including one of immersing the solid-phase extraction medium in the fluid containing metal ions or passing the fluid containing metal ions through the solid-phase extraction medium by continuously circulating the fluid through the solid-phase extraction medium, and extracting the metal ions from the fluid by adsorbing the metal ions onto the solid-phase extraction medium responsive to a contact between the solid-phase extraction medium and the fluid containing metal ions.

Methods For Analyzing Hydrocarbons And Hydrocarbon Blends For Chemical Compositions

The present invention is generally related to the analysis of chemical compositions of hydrocarbons and hydrocarbon blends. This method applies specifically to the problem of analyzing extremely complex hydrocarbon-containing mixtures when the number and diversity of molecules makes it impossible to realistically identify and quantify them individually in a reasonable timeframe and cost. The advantage to this method over prior art is the ability to separate and identify chemical constituents and solvent fractions based on their solvent-solubility characteristics, their high performance liquid chromatographic (HPLC) adsorption and desorption behaviors, and their interactions with stationary phases; and subsequently identify and quantify them at least partially using various combinations of non-destructive HPLC, destructive HPLC, and stand-alone detectors presently not routinely used for HPLC but reconfigured to obtain spectra on the fly. This analytical method is especially useful for, but not limited to, asphalt binders and asphalt binder blends, modified asphalts, asphalt modifiers, asphalt additives, polymer-modified asphalts, asphalts containing rejuvenators and softening agents, asphalts containing recycled products, aged asphalts, and air-blown asphalts, which may contain wide varieties of different types of additives and chemistries, and forensic applications, and environmental pollutant identification.

SYSTEM AND METHOD FOR SORBTION DISTILLATION

A system for distilling water is disclosed. The system comprises a heat source, and a plurality of open-cycle adsorption stages, each stage comprising a plurality of beds and an evaporator and a condenser between a first bed and a second bed, wherein each bed comprises at least two vapor valves, a plurality of hollow tubes, a plurality of channels adapted for transferring water vapor to and from at least one of the condenser or the evaporator, a thermally conductive water vapor adsorbent, and wherein each vapor valve connects a bed to either the condenser or the evaporator. 1. A distillation system , comprising: a plurality of operatively connected beds; and', 'an evaporator and a condenser operatively connected to a first bed of', 'the plurality of beds and a second bed of the plurality of beds;, 'a plurality of operatively connected open-cycle adsorption stages, each stage comprisinga switchable heat source configured to provide heat to one of the plurality of operatively connected beds in one of the plurality of operatively connected open-cycle adsorption stages only during a first operating phase; anda switchable heat exhaust configured to remove heat from another of the plurality of operatively connected beds in one of the plurality of operatively connected open-cycle adsorption stages only during the first operating phase;wherein each bed comprises at least a first, second, and third vapor valve, at least one hollow tube, at least one channel adapted for transferring water vapor to and from at least one of the condenser or the evaporator, a thermally conductive water vapor adsorbent, andwherein the first vapor valve connects the bed to the condenser, the second vapor valve connects the bed to the evaporator, and the third vapor valve connects a volume inside the hollow tubes of the first bed with a volume inside the hollow tubes of the second bed.2. The distillation system of claim 1 , wherein each evaporator and condenser is shared between the first bed and ...

REMOVAL OF MOISTURE FROM HYDRAZINE

The present invention generally relates to the field of gas and liquid phase desiccation. In particular, the present invention relates to methods for removing moisture (and hence oxygen precursors) from hydrazine, thereby providing a high purity source gas suitable for use in vapor deposition processes, such as but not limited to, chemical vapor deposition (CVD) or an atomic layer deposition (ALD). 1. A process for removing moisture from hydrazine , comprising:contacting hydrazine containing moisture with a scavenger wherein the scavenger comprises a support having associated therewith an active scavenging moiety selected from one of more members of the group consisting of: alkali metal compounds, alkaline earth metal compounds, metal oxide or hydroxide compounds and silica-based material.2. The process of claim 1 , wherein said hydrazine containing moisture is in the vaporous state.3. The process of claim 2 , wherein said moisture is present at concentrations of less than 1 ppm.4. The process of claim 2 , wherein said moisture is present at concentrations of less than 50 ppm.5. The process of claim 2 , wherein said moisture is present at concentrations of less than 500 ppb.6. The process of claim 2 , wherein said moisture is present at concentrations of less than 1 ppb.7. The process of claim 1 , wherein said hydrazine containing moisture is in the aqueous liquid state.8. The process of claim 7 , wherein said moisture is present at concentrations of less than 2440 ppm.9. The process of claim 7 , wherein said moisture is present at concentrations of less than 100 ppm.10. The process of claim 7 , wherein said moisture is present at concentrations of less than 30 ppm.11. The process of claim 7 , wherein said moisture is present at concentrations of less than 5 ppm.12. The process of claim 1 , wherein said support is selected from the group consisting of Amberlite resin claim 1 , carbon-based material claim 1 , alumina or silica.13. The process of claim 12 , wherein ...

CHROMATOGRAPHIC MATERIALS

The present invention provides a chromatographic stationary phase material various different types of chromatography. One example chromatographic stationary phase is represented by Formula 1 [X](W)(Q)(T)(Formula 1). X can be a high purity chromatographic core composition. W can be absent and/or can include hydrogen and/or can include hydroxyl on the surface of X. Q can be bound directly to X and can include a first hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte. T can be bound directly to X and can include a second hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte. Additionally, Q and T can essentially eliminate chromatographic interaction between the analyte, and X and W, thereby minimizing retention variation over time (drift or change) under chromatographic conditions utilizing low water concentrations. 1. A chromatographic stationary phase material for normal phase chromatography , high-pressure liquid chromatography , solvated gas chromatography , supercritical fluid chromatography , sub-critical fluid chromatography , carbon dioxide based chromatography , hydrophilic interaction liquid chromatography or hydrophobic interaction liquid chromatography represented by Formula 1:{'br': None, 'sub': a', 'b', 'c, '[X](W)(Q)(T)\u2003\u2003Formula 1'}wherein:X is a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof;W is absent and/or includes hydrogen and/or includes hydroxyl on the surface of X;Q is bound directly to X and comprises a first hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte;T is bound directly to X and comprises a second hydrophilic, polar, ionizable, and/or charged functional group that chromatographically ...

HIGH PURITY CHROMATOGRAPHIC MATERIALS COMPRISING AN IONIZABLE MODIFIER FOR RETENTION OF ACIDIC ANALYTES

The present invention provides the use of charged surface reversed phase chromatographic materials along with standard reversed-phase LC and mass spectrometry compatible conditions for the retention, separation, purification, and characterization of acidic, polar molecules, including, but not limited to, organic acids, α-amino acids, phosphate sugars, nucleotides, other acidic, polar biologically relevant molecules. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier. 1. A method for selectively isolating an acidic , polar molecule from a sample , the method comprising the steps of:a) loading a sample containing an acidic, polar molecule onto a chromatographic separations device comprising a high purity chromatographic material comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifiers such that the acidic, polar molecule is selectively adsorbed onto the high purity chromatographic material, with the proviso that when the ionizable modifier does not contain a Zwitterion, the ionizable modifier does not contain a quaternary ammonium ion moiety; andb) eluting the adsorbed acidic, polar molecule from the high purity chromatographic material, thereby selectively isolating the acidic, polar molecule from the sample.2. A method for separating a plurality of acidic , polar molecules from a sample , the method comprising the steps of:a) loading a sample containing a plurality of acidic, polar molecules onto chromatographic separations device comprising a high purity chromatographic material comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifiers such that the acidic, polar molecules are adsorbed onto the high purity ...

Separating agent for optical isomer

Provided is a novel separating agent for optical isomers based on a helical polymer having optically active sites. The separating agent for optical isomers has a helical polymer having a structure represented by Formula (I), and a carrier that supports the helical polymer, wherein the helical polymer is supported by the carrier. (In Formula (I), X represents a divalent aromatic group, a single bond or a methylene group; R represents hydrogen or a C1-C5 alkoxy; and n represents an integer equal to or higher than 5. When X is a divalent aromatic group, Y represents —CONH—, —COO—, —NHCONH—, —NHCSNH—, —SO 2 NH— or —NHCOO—, and when X is a single bond or a methylene group, Y represents —COO—, —NHCONH—, —NHCSNH— or —NHCOO—.)

POROUS MATERIALS WITH CONTROLLED POROSITY; PROCESS FOR THE PREPARATION THEREOF; AND USE THEREOF FOR CHROMATOGRAPHIC SEPARATIONS

The present invention provides novel chromatographic materials. e.g., for chromatographic separations, processes for their preparation and separations devices containing the chromatographic materials. The chromatographic materials of the invention have controlled porosity and comprise a chromatographic core material and one or more layers of chromatographic surface material which each independently provide an average pore diameter, an average pore volume, or a specific surface area such that the combined layers form a chromatographic material having a predetermined or desired pattern of porosity from the core material to the outermost surface. The materials are useful for HPLC separations, normal-phase selarations, reversed-phase separations, chiral separations, HILIC separations, SFC separations, affinity separations, perfusive separations, partially perfusive separations, and SEC separations. 1. A chromatographic material having controlled porosity.2. The chromatographic material of claim 1 , wherein the material is in the form of a particle.3. The chromatographic material of claim 1 , wherein the material is in the form of a monolith.4. The chromatographic material of claim 1 , wherein the material is in the form of a superficially porous material.5. (canceled)6. (canceled)7. The chromatographic material of claim 1 , comprising a chromatographic core material having a primary surface and one or more layers of a chromatographic surface material.8. (canceled)9. The chromatographic material of claim 7 , wherein the chromatographic core material is an inorganic material claim 7 , an organic material claim 7 , or an inorganic/organic hybrid material.10. (canceled)1222-. (canceled)23. The chromatographic material of claim 7 , wherein each layer of the one or more layers of a chromatographic surface material independently has an average pore diameter of 20 to 1500 Angstroms.24. The chromatographic n material of claim 23 , wherein the average pore diameter of the one or ...

CUCURBITURIL-POLYETHYLENIMINE-SILICA COMPLEX, PREPARATION METHOD THEREOF AND CARBON DIOXIDE ABSORBENT COMPRISING SAME

The present disclosure relates to a cucurbituril-polyethylenimine-silica complex, a method for preparing the same and a carbon dioxide absorbent containing the same. According to the present disclosure, a cucurbituril-polyethylenimine-silica complex may be prepared by forming a complex wherein a cucurbituril is bound to polyethylenimine and including the same inside silica, and it may be used as a carbon dioxide absorbent with superior thermal stability and prevented formation of urea. 2. The cucurbituril-polyethylenimine complex according to claim 1 , wherein the cucurbituril represented by Chemical Formula 1 is cucurbit[6]uril claim 1 , wherein n is 6 claim 1 , each of Aand Ais independently H claim 1 , and X is O.3. The cucurbituril-polyethylenimine complex according to claim 1 , wherein the polyethylenimine has a molecular weight of 100-50000.4. A cucurbituril-polyethylenimine-silica complex comprising a silica and the cucurbituril-polyethylenimine complex according to claim 1 , which is included inside the silica.5. The cucurbituril-polyethylenimine-silica complex according to claim 4 , wherein the cucurbituril-polyethylenimine-silica complex has a BET specific surface area of 1-500 m/g.6. The cucurbituril-polyethylenimine-silica complex according to claim 4 , whereinthe cucurbituril is cucurbit[6]uril,the polyethylenimine has a molecular weight of 500-12000, and{'sup': '2', 'the cucurbituril-polyethylenimine-silica complex has a BET specific surface area of 20-60 m/g.'}7. A carbon dioxide absorbent comprising the cucurbituril-polyethylenimine complex according to .8. A carbon dioxide absorbent comprising the cucurbituril-polyethylenimine-silica complex according to .10. The method for preparing a cucurbituril-polyethylenimine complex according to claim 9 , the solvent is one or more selected from methanol claim 9 , ethanol claim 9 , water claim 9 , dimethylformamide claim 9 , diethylformamide claim 9 , N-methyl-2-pyrrolidone claim 9 , dimethyl sulfoxide and ...

Filter device and analysis device using same

A filter device of the present disclosure includes at least a sheet-shaped fiber structure having a plurality of fibers made of amorphous silicon dioxide, wherein the plurality of fibers are tangled and thus connected together to form voids in the sheet-shaped fiber structure. A filter device of the present disclosure corresponds to an analysis device including: a substrate; a flow path formed on the substrate; and a sheet-shaped fiber structure provided on the inner wall of the flow path, wherein the sheet-shaped fiber structure includes a plurality of fibers made of amorphous silicon dioxide, and the plurality of fibers are tangled and thus connected together to form voids in the sheet-shaped fiber structure.

Solid Phase Mixture, Packing Material, and Column

Provided is a solid phase mixture including an oxidizing agent and/or a salt of the oxidizing agent and solid phase particles. The oxidizing agent is a compound capable of selectively oxidizing 1,2-diol compounds. In addition, a packing material containing the solid phase mixture is provided. Further, a column packed with the packing material is provided. 1. A solid phase mixture comprising:an oxidizing agent and/or a salt of the oxidizing agent; andsolid phase particles.2. The solid phase mixture according to claim 1 , wherein the oxidizing agent is a compound capable of selectively oxidizing 1 claim 1 ,2-diol compounds.3. The solid phase mixture according to claim 1 , wherein the oxidizing agent is periodic acid or lead tetraacetate.4. The solid phase mixture according to claim 1 , wherein the salt of the oxidizing agent is a salt of periodic acid.5. The solid phase mixture according to claim 1 , wherein the solid phase particles are particles of at least one kind selected from diatomaceous earth claim 1 , silica gel claim 1 , dextran claim 1 , and a polymer.6. The solid phase mixture according to claim 5 , wherein the polymer is at least one kind selected from polystyrene claim 5 , polymethacrylate claim 5 , and polyvinyl alcohol.7. The solid phase mixture according to claim 1 , wherein the mass of the oxidizing agent and/or the salt of the oxidizing agent relative to the mass of the solid phase particles is 4% to 20%.8. The solid phase mixture according to claim 1 , configured to selectively bind to and oxidize a 1 claim 1 ,2-diol compound claim 1 , thereby extracting a diol compound other than 1 claim 1 ,2-diol compounds.9. The solid phase mixture according to claim 8 , whereinthe 1,2-diol compound is a vitamin D having a 1,2-diol structure, andthe diol compound other than 1,2-diol compounds is a vitamin D having a diol structure other than a 1,2-diol structure.10. The solid phase mixture according to claim 1 , configured to selectively bind to and oxidize a 1 ...

COMPOSITIONS AND METHODS FOR CALCINING DIATOMACEOUS EARTH WITH REDUCED CRISTOBALITE AND/OR REDUCED BEER SOLUBLE IRON

A method for calcining diatomaceous earth may include adding at least one lattice interfering agent to the diatomaceous earth to form a composite material. The method may further include heating the composite material at a temperature of at least about 800° C. for at least about 15 minutes to form an at least partially calcined composite material. The at least one lattice interfering agent may include at least one cation of at least one of aluminum and titanium. A diatomaceous earth product may include the at least partially calcined composite material formed from the above-noted method for calcining diatomaceous earth. A filter aid may include the diatomaceous earth product. 1. A method for calcining diatomaceous earth , the method comprising:adding at least one lattice interfering agent to the diatomaceous earth to form a composite material; andheating the composite material at a temperature of at least about 800° C. for at least about 15 minutes to form an at least partially calcined composite material,wherein the at least one lattice interfering agent comprises at least one cation of at least one of aluminum and titanium.2. The method of claim 1 , wherein the at least one lattice interfering agent comprises at least one of alumina claim 1 , nepheline syenite claim 1 , perlite claim 1 , kaolin claim 1 , bauxite claim 1 , feldspar claim 1 , clays claim 1 , and other natural and synthetic aluminum-containing compounds.3. The method of claim 1 , wherein the at least one lattice interfering agent comprises at least one of titanium oxide claim 1 , rutile claim 1 , anatase claim 1 , and other natural and synthetic titanium-containing compounds.4. The method of claim 1 , further comprising mixing the at least one lattice interfering agent and the diatomaceous earth.5. The method of claim 4 , wherein the at least one lattice interfering agent and the diatomaceous earth are in dry particulate form during the mixing.6. The method of claim 1 , wherein the composite material ...

PROCESS FOR MANUFACTURING A COMPOSITE SORBENT MATERIAL FOR CHROMATOGRAPHICAL SEPARATION OF BIOPOLYMERS

The present invention relates to a sorbent material for separation and purification of biopolymers, particularly nucleic acids, having a solid support substantially modified with a copolymer coating comprising aromatic monomers and crosslinking compounds and unsaturated esters or ethers preferably attached to the support via a vinylchlorsilane. The use of these materials for separation of nucleic acids, particularly a one-step isolation of DNA from lysates of different biological sources, is an object of the invention as well as a chromatographic column or cartridge at least partially filled with the sorbent material of the invention, a membrane-like device comprising the sorbent material of the invention, and a kit comprising the sorbent material of the invention in bulk or packed in chromatographic devices as well as other devices necessary for performing sample preparations. 122-. (canceled)24. The process of wherein the support is a porous inorganic material comprising inorganic metal oxide.25. The process of wherein the porous inorganic metal oxides show a bidisperse distribution of pore sizes.26. The process of wherein the support has an average pore size of 2-200 nm.27. The process of wherein the polymer coating has a thickness of about 10 to 250 Angström.28. The process of wherein the inorganic metal oxide is selected from the group consisting of oxides of aluminum claim 24 , titanium claim 24 , zirconium claim 24 , silicon oxides claim 24 , iron oxides claim 24 , controlled pore glass (CPG) claim 24 , diatomaceous earth and combinations thereof.29. The process of wherein the porous inorganic metal oxide shows a bidisperse distribution with mean pore diameters in the range of 20-100 nm for the larger pore size.30. The process of wherein the porous inorganic metal oxide has a mean pore diameter in the range of 2-15 nm for the smaller pore size.31. The process of wherein the ratio of the mean diameter of the large pore size distribution and the lower pore size ...

Functionalized chromatographic materials and methods of making and using therefor

Methods, compositions, devices and kits having a novel chromatographic material are provided herein for separating and identifying organic molecules and compounds, for example molecules and compounds containing electron rich functional groups such as carbon-carbon double bonds. The methods, compositions, and kits include a metal-thiolate chromatographic medium (MTCM) with a sulfur-containing functional group or a metal-selenolate chromatographic medium (MSCM) comprising a selenium-containing functional group covalently attached to a support medium, such that the sulfur-containing functional group or selenium-containing functional group is bound to at least one metal atom. The MTCM and/or MSCM has affinity and specificity to compounds having one or more carbon-carbon double bonds, and performs a highly efficient and rapid separation of samples yielding non-overlapping peaks of purified materials compared to traditional media. 173-. (canceled)74. A separation system comprising: a chromatographic medium comprising atoms of a transition metal selected from the group consisting of copper , gold and a combination thereof , present as a stationary phase in a pipette or column , wherein the chromatographic medium comprises selenium-containing functional group (MSCM) , and wherein the selenium-containing functional group is linked to a support by at least one spacer , and a sample source coupled to the pipette or column comprising a sample to be separated , wherein the sample includes a compound having a functional group.75. The chromatographic medium according to claim 74 , on a support selected from the group consisting of silica gel claim 74 , alumina claim 74 , polystyrene claim 74 , agarose claim 74 , modified polymeric resin claim 74 , cellulose claim 74 , magnesium silicate claim 74 , dextran claim 74 , and starch.76. The chromatographic medium according to claim 74 , configured as an analytical component of a chromatographic separation system selected from: normal ...

Porous Silica Powder

An object of the present invention is to provide a porous silica powder suitable for, for example, a gas chromatography support, and the porous silica powder has an average pore diameter of 0.5 to 10 μm as determined by a mercury intrusion method, a volume of pores having a 100 nm or smaller pore diameter of 0.2 cm/g or less as determined by a nitrogen gas adsorption method, a specific surface area of 0.5 to 100 m/g as determined by a nitrogen gas adsorption method, and a particle size distribution of 10 to 1000 μm. 1. A porous silica powder having:an average pore diameter of 0.5 to 10 μm as determined by a mercury intrusion method;a volume of pores having a 100 nm or smaller pore diameter of 0.2 cm3/g or less as determined by a nitrogen gas adsorption method;a specific surface area of 0.5 to 100 m2/g as determined by a nitrogen gas adsorption method; anda particle size distribution of 10 to 1000 μm.2. The porous silica powder according to claim 1 , wherein:the average pore diameter is 0.8 to 5.0 μm;the pore volume is 0.001 to 0.1 cm3/g; andthe specific surface area is 0.7 to 50.0 m2/g.3. The porous silica powder according to claim 1 , having a bulk specific gravity of 0.2 to 0.7 g/mL.4. The porous silica powder according to claim 1 , obtained by pulverizing or granulating porous silica formed from a reaction mixture comprising acid claim 1 , a water-soluble polymer claim 1 , and organosilicate.5. The porous silica powder according to claim 4 , obtained by forming the porous silica from the reaction mixture using a sol-gel method claim 4 , and firing the porous silica before or after pulverization or granulation.6. A gas chromatography support claim 1 , comprising the porous silica powder of .7. An adsorbent for a liquid component or a gas component claim 1 , comprising the porous silica powder of .8. The porous silica powder according to claim 2 , having a bulk specific gravity of 0.2 to 0.7 g/mL.9. The porous silica powder according to claim 2 , obtained by ...

CHROMATOGRAPHIC COLUMNS AND SEPARATION DEVICES COMPRISING A SUPERFICIALLY POROUS MATERIAL; AND USE THEREOF FOR SUPERCRITICAL FLUID CHROMATOGRAPHY AND OTHER CHROMATOGRAPHY

The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are superficially porous chromatographic particulate materials comprising sized less than 2 microns. 156-. (canceled)57. A method for performing supercritical fluid chromatography comprising the steps ofproviding a sample to be separated by supercritical fluid chromatography;loading the sample onto a stationary phase comprising superficially porous silica particles, superficially porous inorganic/organic hybrid particles, or a superficially porous particulate material comprising a substantially nonporous core and one or more layers of a porous shell material surrounding the core; andperforming supercritical fluid chromatography to separate said sample;wherein the tailing factor associated with the stationary phase is about 0.80-2.0.58. The method according to claim 57 , wherein the tailing factor associated with the stationary phase is about 0.85-1.60.59. The method according to claim 58 , wherein the tailing factor associated with the stationary phase is about claim 58 , about 0.90-1.30.60. The method according to claim 59 , wherein the tailing factor associated with the stationary phase is about 0.95-1.20.61. The method according to claim 60 , wherein the tailing factor associated with the stationary phase is about 1.00-1.0.62. A superficially porous material having the Formula 1:{'br': None, '[X](W)a(Q)b(T)c \u2003\u2003Formula 1'}wherein:X is a superficially porous silica material, a superficially porous inorganic/organic hybrid material, or a superficially porous particulate material comprising a substantially nonporous core and one or more layers of a porous shell material surrounding the core;W is absent ...

MULTICAPILLARY MONOLITH

The invention relates to a monolithic porous material made of amorphous silica or activated alumina, comprising substantially rectilinear capillary channels that are parallel to one another, wherein: 1. A process for preparing a monolithic porous material based on amorphous silica or activated alumina comprising substantially rectilinear capillary channels parallel to one another , comprising the steps of:providing a bundle of so-called channel precursor fibres whose diameter is equal to the diameter of the capillary channels,forming a porous matrix of amorphous silica or activated alumina around the fibres,eliminating the fibres so as to form said capillary channels in said matrix.2. The process of claim 1 , wherein the channel precursor fibres comprise an ablative layer of a coating material that is removed during a first fibre elimination treatment step.3. The process of claim 1 , wherein the channel precursor fibres are coated with a spacer before forming the bundle to ensure a minimum thickness of monolith between two adjacent channels.4. The process of claim 1 , wherein the porous matrix of amorphous silica has a high proportion of macropores allowing the circulation of a fluid in the monolith.5. The process of claim 1 , wherein the fibres are formed of a hydrolysable polymer claim 1 , in that the fibres are assembled in a bundle claim 1 , in that the bundle is immersed in a silica gel precursor solution claim 1 , the solution being caused to gel around the fibres claim 1 , and in that the fibres are eliminated by hydrolysis to soluble species of low molecular weight.6. The process of claim 1 , wherein the channel precursor fibres are metal wires with low melting point coated with a film of silica or activated alumina claim 1 , assembled in a bundle claim 1 , in that the bundle is immersed in a silica gel or activated alumina precursor solution claim 1 , the solution being caused to gel around the fibres claim 1 , and in that the fibres are eliminated by ...

AMINE GRAFTED SILICA GELS

A method of grafting a silica support includes adding the silica support to a solvent, resulting in a first solution, adding an amount of silane to the first solution, resulting in a second solution, filtering grafted silica support from the second solution, and drying the grafted silica support. 1. An adsorbent , the adsorbent comprising:silicon dioxide having a plurality of pores; andsilane disposed on the plurality of pores, wherein the silane is interconnected by siloxane bridges.2. The adsorbent of claim 1 , wherein the silane is N-(3-Trimethoxysilylpropyl) diethylenetriamine having a chemical formula of (CHO)Si(CH)NHCHCHNHCHCHNH.3. The adsorbent support of claim 1 , wherein the silicon dioxide is a mesoporous silica support claim 1 , andwherein each pore of the plurality of pores has a diameter of greater than 6 nanometers.4. The adsorbent of claim 1 , wherein an average diameter of each pore of the plurality of pores is within 10-15 nanometers.5. The adsorbent of claim 1 , wherein the adsorbent has a surface area of less than 1800 square meters per gram of silicon dioxide.6. The adsorbent of claim 1 , wherein the silicon dioxide has a surface area between 290-320 square meters per gram.7. A method of grafting a silica support claim 1 , the method comprising:adding the silica support to a solvent, resulting in a first solution;adding an amount of silane to the first solution, resulting in a second solution;filtering grafted silica support from the second solution; anddrying the grafted silica support.8. The method of claim 7 , wherein the silane is N-(3-Trimethoxysilylpropyl) diethylenetriamine having a chemical formula of (CHO)Si(CH)NHCHCHNHCHCHNH.9. The method of claim 7 , further comprising:adding an amount of water to the first solution.10. The method of claim 9 , wherein the amount of silane added to the first solution is greater than the amount of water added to the first solution.11. The method of claim 10 , wherein the amount of silane is more than 33 ...

NEW ULTRAHIGH EFFICIENCY, SUPERFICIALLY POROUS PARTICLE (SPP) CHIRAL PHASES FOR LIQUID CHROMATOGRAPHY

The present invention relates to a novel stationary phase support for liquid chromatographic chiral separations. The specific combination of the special underlying support material and certain classes of known chiral selectors according to the invention produces far superior chiral (enantiomeric) separations than those obtained on any conventionally known supports. These chiral (enantiomeric) separations are enhanced in terms of significantly higher efficiencies (theoretical plate numbers), higher resolutions (R), shorter retention times and either equivalent or slightly higher selectivities than those obtained on conventional supports. 1. (canceled)3. (canceled)4. The stationary phase according to claim 2 , wherein the SPP has a particle diameter from about 0.5 microns to about 20 microns.5. (canceled)6. (canceled)7. The stationary phase according to claim 2 , wherein the SPP has a particle diameter selected from the group consisting of about 1.7 claim 2 , about 2.7 and about 4.0 microns.8. (canceled)9. (canceled)10. (canceled)11. The stationary phase according to claim 2 , wherein the SPP has a pore size from about 100 angstroms to about 300 angstroms.12. (canceled)13. (canceled)14. (canceled)15. (canceled)16. The stationary phase according to claim 2 , wherein the SPP has a surface area of about 120 m/g.17. The stationary phase according to claim 2 , wherein the chiral selectors are covalently bonded to the SPP.18. The stationary phase according to claim 2 , wherein the chiral selectors are selected from the group consisting of oligosaccharides and derivatives claim 2 , cyclic oligosaccharides and derivatives claim 2 , peptides and derivatives claim 2 , glycopeptides and derivatives claim 2 , macrocyclic glycopeptides and derivatives claim 2 , pi-complexes claim 2 , chiral crown ethers claim 2 , ligand exchangers and ion exchangers.19. The stationary phase according to claim 2 , wherein the chiral selectors are selected from the group consisting of cyclodextrins ...

Separating agent

Provided is a novel separating agent obtained by using core/shell particles as a support and fixing any of various ligands to the support by physical adsorption. The separating agent contains a support and a ligand fixed to the surface of the support by physical adsorption, and is characterized in that the support is core/shell particles each formed of a core constituted of a nonporous inorganic substance and a porous shell, the shell having a pore diameter of 30 nm or larger, the shell being constituted of a hydrolyzate of a polyalkoxysiloxane, and the ligand is an optically active polymer, an optically inactive polyester, a protein, or a nucleic acid.

CATALYST ADDITIVATED WITH ALKYL LACTATE, PREPARATION THEREOF AND USE THEREOF IN A HYDROTREATING AND/OR HYDROCRACKING PROCESS

The invention relates to a catalyst comprising a support based on alumina or silica or silica-alumina, at least one group VIII element, at least one group VIB element and at least one organic compound of formula (I) 2. The catalyst as claimed in claim 1 , in which the compound of formula (I) is chosen from methyl lactate claim 1 , ethyl lactate claim 1 , propyl lactate claim 1 , butyl lactate claim 1 , isobutyl lactate claim 1 , isopentyl lactate claim 1 , cis-3-hexenyl lactate claim 1 , L-menthyl lactate claim 1 , butyl butyryl lactate claim 1 , ethyl 2-mercaptopropanoate claim 1 , methyl glycolate claim 1 , ethyl glycolate claim 1 , butyl glycolate claim 1 , ethyl ethoxyacetate claim 1 , ethyl α-hydroxyisobutanoate claim 1 , tert-butyl α-hydroxyisobutanoate claim 1 , ethyl 2-hydroxycaproate and ethyl 2-hydroxyvalerate.3. The catalyst as claimed in claim 1 , in which Rrepresents a methyl radical and Rrepresents a hydrogen atom.4. The catalyst as claimed in claim 1 , in which the compound of formula (I) is chosen from butyl lactate and butyl butyryl lactate.5. The catalyst as claimed in claim 1 , in which the content of Group VIB element is between 5% and 40% by weight expressed as Group VIB metal oxide relative to the total weight of the catalyst and the content of Group VIII element is between 1% and 10% by weight expressed as Group VIII metal oxide relative to the total weight of the catalyst.6. The catalyst as claimed in claim 1 , in which the mole ratio of Group VIII element to Group VIB element in the catalyst is between 0.1 and 0.8.7. The catalyst as claimed in claim 1 , which also contains phosphorus claim 1 , the phosphorus content being between 0.1% and 20% by weight expressed as POrelative to the total weight of the catalyst and the mole ratio of phosphorus to the Group VIB element in the catalyst is greater than or equal to 0.05.8. The catalyst as claimed in claim 1 , in which the content of compound of formula (I) is between 1% and 45% by weight ...

HIGH EFFICIENCY, ULTRA-STABLE, BONDED HYDROPHILIC INTERACTION CHROMATOGRAPHY (HILIC) MATRIX ON SUPERFICIALLY POROUS PARTICLES (SPPS)

The present invention relates to superficially porous particles (SPPs), also called core-shell, porous shell or fused core particles, which are state-of-the-art support materials used in the production of HPLC columns. Hydrolytically stable, highly selective superficially porous particle (SPP) hydrophilic interaction liquid chromatographic (HILIC) stationary phases having higher efficiencies and shorter retention times than analogous stationary phases on fully porous particles (FPP) is provided. 1. Covalently bonded ultra-stable hydrophilic interaction chromatography (HILIC) phases comprising superficially porous particle (SPP) linked to a HILIC selector.2. The covalently bonded ultra-stable hydrophilic interaction chromatography (HILIC) phases of claim 1 , wherein SPP has a particle diameter from about 0.5 microns to about 20 microns.3. The covalently bonded ultra-stable hydrophilic interaction chromatography (HILIC) phases of claim 1 , wherein SPP has a particle diameter from about 1.3 microns to about 10 microns.4. The covalently bonded ultra-stable hydrophilic interaction chromatography (HILIC) phases of claim 1 , wherein SPP has a particle diameter from about 1.7 microns to about 5.0 microns.5. The covalently bonded ultra-stable hydrophilic interaction chromatography (HILIC) phases of claim 1 , wherein SPP has a particle diameter selected from the group consisting of about 1.7 claim 1 , about 2.7 and about 4.0 microns.6. (canceled)7. (canceled)8. (canceled)9. The covalently bonded ultra-stable hydrophilic interaction chromatography (HILIC) phases of claim 1 , wherein the SPP has a pore size from about 100 angstroms to about 300 angstroms.10. (canceled)11. (canceled)12. The covalently bonded ultra-stable hydrophilic interaction chromatography (HILIC) phases of claim 1 , wherein the SPP has a pore size of about 120 angstroms.13. The covalently bonded ultra-stable hydrophilic interaction chromatography (HILIC) phases of claim 1 , wherein the SPP has a surface area ...

POROUS INORGANIC/ORGANIC HYBRID PARTICLES HAVING HIGH ORGANIC CONTENT AND ENHANCED PORE GEOMETRY FOR CHROMATOGRAPHIC SEPARATIONS

Novel particles and materials for chromatographic separations, processes for preparation and separations devices containing the chromatographic particles and materials are provided by the instant invention. In particular, the invention provides a porous inorganic/organic hybrid particle, wherein the inorganic portion of the hybrid particle is present in an amount ranging from about 0 molar % to not more than about 49 molar %, wherein the pores of the particle are substantially disordered. The invention also provides a porous inorganic/organic hybrid particle, wherein the inorganic portion of the hybrid particle is present in an amount ranging from about 25 molar % to not more than about 50 molar %, wherein the pores of the particle are substantially disordered and wherein the particle has a chromatographically enhancing pore geometry (CEPG). Methods for producing the hybrid particles, separations devices comprising the hybrid particles and kits are also provided. 13-. (canceled)4. A porous inorganic/organic hybrid particle , comprising SiOin an amount ranging from about 0 molar to not more than about 25 molar % , wherein die pores of the particle are substantially disordered.59-. (canceled)10. The porous inorganic/organic hybrid particle of claim 4 , wherein the porous inorganic/organic hybrid particle has formula IV:{'br': None, 'sub': x', 'y', 'z, '(A)(B)(C)\u2003\u2003(IV),'}wherein the order of repeat units A, B, and C may be random, block, or a combination of random and block;A is an organic repeat unit which is covalently bonded to one or more repeat units A or B via an organic bond;B is an organosiloxane repeat unit which is bonded to one or more repeat units B or C via an inorganic siloxane bond and which may be further bonded to one or more repeat units A or B via an organic bond;C is an inorganic repeat unit which is bonded to one or more repeat units B or C via an inorganic bond; andx and y are positive numbers and z is a non negative number, wherein when ...

Superficially porous materials comprising a substantially nonporous core having narrow particle size distribution; process for the preparation thereof; and use thereof for chromatographic separations

Novel chromatographic materials for chromatographic separations, columns, kits, and methods for preparation and separations with a superficially porous material comprising a substantially nonporous core and one or more layers of a porous shell material surrounding the core. The material of the invention is comprised of superficially porous particles and a narrow particle size distrution. The material of the invention is comprised of a superficially porous monolith, the substantially nonporous core material is silica; silica coated with an inorganic/organic hybrid surrounding materia; a magnetic core material; a magnetic core material coated with silica; a high thermal conductivity core material; a high thermal conductivity core material coated with silica; a composite material; an inorganic/organic hybrid surrounding material; a composite material coated with silica; a magnetic core material coated with an inorganic/organic hybrid surrounding material; or a high thermal conductivity core material coated with an inorganic/organic hybrid surrounding material.

CHROMATOGRAPHIC MATERIAL AND METHODS FOR THE SYNTHESIS THEREOF

A particulate material for chromatographic use comprising silica particles is provided having a skeleton structure containing silsesquioxane cage moieties. The material is useful as a chromatographic material, for example in HPLC. The silica particles may be hybrid organo-silica particles wherein the silsesquioxane moieties comprise a cage structure having silicon atoms positioned at corners of the cage wherein one or more silicon atoms positioned at the corners of the cage carry an organic group. A preferred method of preparing the particulate material comprises hydrolysing a silsesquioxane as a co-component of a hydrolysis mixture, especially in a Stöber or modified Stöber process. 1. A particulate material for chromatographic use comprising silica particles having a skeleton structure containing silsesquioxane moieties having a cage structure.2. A particulate material as claimed in wherein the silica particles are hybrid organo-silica particles wherein the silsesquioxane moieties comprise a cage structure having silicon atoms positioned at corners of the cage wherein one or more silicon atoms positioned at the corners of the cage carry an organic group.3. A particulate material as claimed in wherein the organic group is a hydrocarbon group.4. A particulate material as claimed in wherein the hydrocarbon group is an alkyl group or aryl group.5. A particulate material as claimed in wherein the cage structure has a missing corner.6. A particulate material as claimed in wherein the cage structure has one or more missing corners and one or more missing edges.7. A particulate material as claimed in wherein the cage structure comprises seven or six corner silicon atoms and each corner silicon atom carries an organic group.8. A particulate material as claimed in wherein the cage structure comprises seven corner silicon atoms and each corner silicon atom carries an organic group.9. A particulate material as claimed in wherein the hybrid organo silica particles have a ...

FILTRATION MATERIAL, FILTRATION FILTER, METHOD FOR MANUFACTURING FILTRATION MATERIAL, FILTRATION METHOD, COPOLYMER, AND METHOD FOR MANUFACTURING COPOLYMER

A filtration material including a silica base material having a group represented by the following general formula (a0-1) [in formula (a0-1), Yarepresents a divalent linking group; Rarepresents a hydrocarbon group which may have a substituent; Rarepresents a hydroxyl group or a hydrocarbon group having 1 to 6 carbon atoms which may have a substituent; nrepresents an integer of 0 to 5; and the symbol “*” represents a valence bond with respect to the silica base material]. 2. The filtration material according to claim 1 , wherein said silica base material is a porous and flexible silica fiber.3. The filtration material according to claim 1 , wherein said silica base material is a silica gel.4. The filtration material according to claim 3 , wherein said silica gel has a particle size of 2 to 50 μm.8. The filtration material according to claim 1 , wherein said filtration material is used for filtering a resist composition or an organic solvent.9. A filtration filter comprising the filtration material according to .10. A filtration method comprising passing a resist composition or an organic solvent through the filtration filter according to to remove impurities in the resist composition or the organic solvent.11. The filtration method according to claim 10 , wherein said impurities are metal components.13. The method for producing a filtration material according to claim 12 , wherein said filtration material is used for filtering a resist composition or an organic solvent.14. The method for producing a filtration material according to claim 12 , wherein said filtration material is a filtration filter.15. A filtration method comprising passing a resist composition or an organic solvent through a filtration material obtained by the method according to to remove impurities in the resist composition or the organic solvent.16. The filtration method according to claim 15 , wherein said impurities are metal components. The present invention relates to a filtration material, a ...

Hydrocarbon Analysis Methods

A method for determining asphaltene stability in a hydrocarbon-containing material having solvated asphaltenes therein is disclosed. In at least one embodiment, it involves the steps of: (a) precipitating an amount of the asphaltenes from a liquid sample of the hydrocarbon-containing material with an alkane mobile phase solvent in a column; (b) dissolving a first amount and a second amount of the precipitated asphaltenes by changing the alkane mobile phase solvent to a final mobile phase solvent having a solubility parameter that is higher than the alkane mobile phase solvent; (c) monitoring the concentration of eluted fractions from the column; (d) creating a solubility profile of the dissolved asphaltenes in the hydrocarbon-containing material; and (e) determining one or more asphaltene stability parameters of the hydrocarbon-containing material. 1. A method for determining an effectiveness of one or more asphaltene dispersant additives for inhibiting or preventing asphaltene precipitation in a hydrocarbon-containing material subjected to an elevated temperature and pressure conditions , the method comprising the steps of:(a) subjecting a first column having an inert packing material therein to a first set of the elevated temperature and pressure conditions comprising a temperature ranging from 140 degree C. to 450 degree C. and a pressure ranging from 1 to 200 standard atmosphere (atm);(b) precipitating an amount of asphaltenes from a first hydrocarbon-containing material sample having solvated asphaltenes therein with one or more first asphaltene-precipitating mobile phase solvents and capturing precipitated asphaltenes in the inert packing material in the first column;{'sup': '0.5', '(c) dissolving an amount of the precipitated asphaltenes at a predetermined temperature with one or more first solvents having a solubility parameter of at least 21 MPabut no greater than 30 MPa.sup.0.5 to elute a first fraction having dissolved asphaltenes therein;'}(d) ...

METHODS OF PREPARATION AND MANUFACTURE OF BIOCOMPATIBLE SOLID-PHASE MICROEXTRACTION COATINGS AND COATED DEVICES

Fibres with an extraction phase coated thereon in combination with a positioning device are described to perform adsorption of components of interest from an animal or animal tissue for the investigation of living systems. A number of interfaces to analytical instrumentation are disclosed including mass spectrometry, LC/MS, MALDI and CE as well as direct spectroscopic on-fibre measurement. 120-. (canceled)21. A device for collecting a component from an animal or animal tissue , said device comprising:at least one fibre having an end which is at least partially coated with an extraction phase for extracting said component;wherein said fibre is at least partially coated with a biocompatible protection layer.22. The device of claim 21 , wherein said biocompatible protection layer comprises polydimethylsiloxane claim 21 , poly(divinylbenzene) claim 21 , polypyrrole claim 21 , or derivatised cellulose.23. The device of claim 21 , wherein said extraction phase comprises a polymeric composition selected from the group consisting of substituted or unsubstituted poly (dimethylsiloxane) particles claim 21 , polyacrylate particles claim 21 , poly(ethylene glycol) claim 21 , carboxen particles claim 21 , poly(divinylbenzene) particles claim 21 , polypyrrole claim 21 , and molecular imprinted polymers.24. The device of claim 21 , wherein said extraction phase is a matrix for a MALDI-TOFMS analysis.25. The device of claim 21 , further comprising an openable housing for said fibre.26. The device of claim 21 , further comprising a positioning device for guiding said end into position within the animal or animal tissue.27. The device of claim 26 , wherein said positioning device includes a catheter.28. The device of claim 21 , comprising a plurality of said fibres capable of being simultaneously positioned in separate locations in said animal or animal tissue.29. The device of claim 21 , in a form suitable for positioning said fibre within an analytical instrument. This application ...

CHROMATOGRAPHIC MATERIALS

In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)(Q)(T)(Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0. 262-. (canceled)63. The chromatographic stationary phase material of claim 1 , wherein the chromatographic stationary phase material is in the form of a plurality of particles.64. The chromatographic stationary phase material of claim 1 , wherein the chromatographic stationary phase material is in the form of a monolith.65. The chromatographic stationary phase material of claim 1 , wherein the chromatographic stationary phase material is in the form of a superficially porous material.66. The chromatographic stationary phase material of claim 1 , wherein the chromatographic stationary phase material has chromatographically enhancing pore geometry.67. The chromatographic stationary phase material of claim 63 , wherein the plurality of particles have sizes between about 1.5 and 5 microns.68. The chromatographic stationary phase material of claim 1 , wherein the chromatographic stationary phase material has a surface area of about 25 to 1100 m/g.69. The chromatographic stationary phase material of claim 1 , wherein the chromatographic stationary phase material has a pore volume of about 0.2 to 2.0 cm/g.70. The ...

PRODUCTION METHOD FOR CORE-SHELL POROUS SILICA PARTICLES

Provided is a production method for core-shell porous silica particles, the production method including: a preparation step of preparing an aqueous solution comprising non-porous silica particles, a cationic surfactant, a basic catalyst, an electrolyte, and an alcohol; a shell precursor formation step of adding a silica source to the aqueous solution to form a shell precursor on a surface of the non-porous silica particles; and a shell formation step of removing the cationic surfactant from the shell precursor to form a porous shell. 1. A method for producing core-shell porous silica particles , the method comprising:a preparation step of preparing an aqueous solution comprising non-porous silica particles, a cationic surfactant, a basic catalyst, an electrolyte, and an alcohol;a shell precursor formation step of adding a silica source to the aqueous solution to form a shell precursor on a surface of the non-porous silica particles; anda shell formation step of removing the cationic surfactant from the shell precursor to form a porous shell.2. The production method according to claim 1 , wherein a concentration of the electrolyte in the aqueous solution is from 1 mM to 4 mM.3. The production method according to claim 1 , wherein the electrolyte is a chlorine-based electrolyte claim 1 , a bromine-based electrolyte claim 1 , or an iodine-based electrolyte.4. The production method according to claim 3 , wherein the chlorine-based electrolyte is sodium chloride claim 3 , potassium Chloride or lithium chloride.5. The production method according to claim 3 , wherein the bromine-based electrolyte is sodium bromide claim 3 , potassium bromide claim 3 , or lithium bromide.6. The production method according to claim 3 , wherein the iodine-based electrolyte is sodium iodide claim 3 , potassium iodide claim 3 , or lithium iodide.7. The production method according to claim 1 , wherein the cationic surfactant is a hexadecyltrimethylammonium halide or an octadecyltrimethylammonium ...

POROUS PARTICLES FOR LIQUID CHROMATOGRAPHY AND PROCESSES FOR THE PREPARATION THEREOF

Superficially porous silica particles are provided as well as a one-pot process for making the superficially porous particles, the process comprising hydrolyzing and condensing a silica precursor comprising a functional group to form superficially porous particles, the superficially porous particles comprising silica microparticles having silica nanoparticles bound to the surface of the microparticles. The nanoparticles provide a porous outer layer on the microparticles. The superficially porous particles are useful as a stationary phase in liquid chromatography and allow for fast mass transfer and separation of samples 1. A one-pot process for making superficially porous silica particles , the process comprising hydrolyzing and condensing a silica precursor comprising a functional group to form superficially porous silica particles , the superficially porous silica particles comprising substantially non-porous silica microparticles having silica nanoparticles bound to the surface of the microparticles.2. The process according to wherein the functional group is a mercapto group.3. The process according to wherein the precursor comprises a mercapto-silane.4. The process according to wherein the mercapto-silane comprises 3-mercapto-propyl-trimethoxy-silane.5. The process according to according to wherein the precursor is used as the sole silica source.6. The process according to according to wherein the hydrolyzing and condensing the precursor is performed in a basic medium having a starting pH in the range 9 to 11.7. The process according to according to wherein the hydrolyzing and condensing the precursor is performed in a medium which comprises water and an organic solvent.8. The process according to wherein the organic solvent comprises methanol.9. The process according to according to wherein the hydrolyzing and condensing the precursor is performed in the presence of a surfactant.10. The process according to wherein the surfactant comprises a quaternary ammonium ...

Functionalized Particulate Support Material and Methods of Making and Using the Same

Functionalized particulate support material suitable for use in chromatography columns or cartridges, such as in a liquid chromatography (HPLC) column, is disclosed. Chromatography columns or cartridges containing the functionalized particulate support material, methods of making functionalized particulate support material, and methods of using functionalized particulate support material, such as a media in a chromatography column or cartridge, are also disclosed. 1. A functionalized particulate support material comprising:a particle having a particle surface; anda combination of functional groups extending from the particle surface, said combination of functional groups comprising (i) a first set of functional groups that enable polymerization of one or more monomers onto the particle surface via the first set of functional groups, and (ii) a second set of functional groups that increases the wettability of said particle surface.2. The functionalized particulate support material of claim 1 , wherein said second functional group is bonded to said one or more monomers or to the particle surface.3. The functionalized particulate support material of or claim 1 , wherein said particle comprises an inorganic particle.43. The functionalized particulate support material of any one of to claims 1 , wherein said particle comprises a silica particle.54. The functionalized particulate support material of any one of to claims 1 , wherein said particle has a particle size claims 1 , as measured by a median particle dimension claims 1 , ranging from about 1 μm to about 120 μm.65. The functionalized particulate support material of any one of to claims 1 , wherein said particle comprises a porous particle having a particle size claims 1 , as measured by a median particle dimension claims 1 , ranging from about 10 μm to about 120 μm claims 1 , and a median pore size of at least 150 Å.76. The functionalized particulate support material of any one of to claims 1 , wherein said first ...

DIFLUOROACETIC ACID ION PAIRING REAGENT FOR HIGH SENSITIVITY, HIGH RESOLUTION LC-MS OF BIOMOLECULES

The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 0.20% (v/v) difluoroacetic acid and less than about 100 ppb of any individual metal impurity. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample. 1. A method of separating an analyte from a sample , the method comprising:flowing a mobile phase through a chromatography column wherein the mobile phase comprises about 0.005% (v/v) to about 0.20% (v/v) difluoroacetic acid and less than about 100 ppb of any individual metal impurity;injecting a sample comprising the analyte into the mobile phase; andseparating the analyte from the sample.2. The method of claim 1 , wherein the chromatography column is a liquid chromatography column.3. The method of claim 1 , wherein the chromatography column is a reversed phase chromatography column.4. The method of claim 1 , wherein the chromatography column further comprises a stationary phase having a phenyl-based surface chemistry.5. The method of claim 4 , wherein the stationary phase is a superficially porous silica stationary phase bonded with phenyl moieties.6. The method of claim 4 , wherein the stationary phase is a fully porous silica stationary phase bonded with phenyl moieties.7. The method of claim 4 , wherein the stationary phase is an organosilica stationary phase bonded with phenyl moieties.8. The method of claim 1 , wherein the chromatography column further comprises a stationary phase having a polymeric polystyrene divinyl benzene surface chemistry.9. The method of claim 1 , wherein the mobile phase comprises less than about 50 ppb of any individual metal impurity.10. The method of claim 1 , wherein the mobile phase comprises less than about 20 ppb of any individual metal impurity ...

CHROMATOGRAPHIC MATERIAL AND METHODS FOR THE SYNTHESIS THEREOF

A particulate material for chromatographic use comprising silica particles is provided having a skeleton structure containing silsesquioxane cage moieties. The material is useful as a chromatographic material, for example in HPLC. The silica particles may be hybrid organo-silica particles wherein the silsesquioxane moieties comprise a cage structure having silicon atoms positioned at corners of the cage wherein one or more silicon atoms positioned at the corners of the cage carry an organic group. A preferred method of preparing the particulate material comprises hydrolysing a silsesquioxane as a co-component of a hydrolysis mixture, especially in a Stöber or modified Stöber process. 1. A liquid chromatography stationary phase comprising:silica particles formed via co-condensation of a Si moiety of an alkoxysilane with a silsesquioxane moiety in a presence of a surfactant, a water, an organic solvent, and a base,in which the silsesquioxane moiety has a cage structure,in which the silica particles include Si-silsesquioxane-Si linkages,in which the silica particles comprise an internal structure and a surface,in which the silsesquioxane moieties are contained in the internal structure of the silica particles via the Si-silsesquioxane-Si linkages, andin which the silica particles are configured to be packed into a chromatography column.2. The liquid chromatography stationary phase of claim 1 , wherein the silica particles are hybrid organo-silica particles claim 1 , wherein the cage structure of the silsesquioxane moieties comprise silicon atoms positioned at corners of the cage structure claim 1 , wherein one or more of the silicon atoms positioned at the corners of the cage structure include an organic group.3. The liquid chromatography stationary phase of claim 2 , wherein the organic group is a hydrocarbon group.4. The liquid chromatography stationary phase of claim 2 , wherein the hybrid organo silica particles have a formula selected from the group consisting of: ...

SILICA AGGREGATE, ADSORBENT, ADSORPTION COLUMN, CLEANING SYSTEM, METHOD FOR TREATING LIQUID, AND METHOD FOR PRODUCING SILICA AGGREGATE

A silica aggregate includes primary silica particles aggregated, the primary silica particles having an average particle size of 1 nm or more and less than 10 nm, the primary silica particles being crosslinked to each other by a bond containing a siloxane bond. 1. A silica aggregate , comprising:primary silica particles aggregated,the primary silica particles having an average particle size of 1 nm or more and less than 10 nm,the primary silica particles being crosslinked to each other by a bond containing a siloxane bond.2. The silica aggregate according to claim 1 , wherein the silica aggregate contains aluminum oxide on at least a portion of a surface thereof.3. The silica aggregate according to claim 2 , wherein a percentage by mass of the aluminum oxide with respect to silica in the silica aggregate is 3% or more by mass.4. The silica aggregate according to claim 1 , wherein the silica aggregate has an average particle size of 10 μm or more and 2 claim 1 ,000 μm or less.5. The silica aggregate according to claim 1 , wherein the primary silica particles have an average particle size of 4 nm or more and 6 nm or less.6. The silica aggregate according to claim 1 , wherein the silica aggregate contains an amino group or an epoxy group on a surface thereof.7. The silica aggregate according to claim 1 , wherein the silica aggregate is used for adsorption of a metal ion.8. The silica aggregate according to claim 7 , wherein the metal ion is an ion containing at least one element selected from the group consisting of cesium claim 7 , strontium claim 7 , ruthenium claim 7 , lead claim 7 , cadmium claim 7 , zinc claim 7 , copper claim 7 , iron claim 7 , nickel claim 7 , silver claim 7 , rhodium claim 7 , palladium claim 7 , and iridium.9. The silica aggregate according to claim 1 , further comprising:DNA immobilized on the silica aggregate.10. The silica aggregate according to claim 9 , wherein the silica aggregate has a DNA content of 1% or more by mass and 50% or less ...

PURINE BASE ADSORPTION MATERIAL, PURINE BASE ADSORPTION FILTER USING THE SAME, PURINE BASE ADSORPTION COLUMN FILLER, AND PURINE BASE REMOVAL SYSTEM USING THE SAME

A purine base adsorption material contains a 2:1 type layered clay mineral of [(E1m+a/mE2+b)(M1cM2d)(Si4-eAle)O10(OHfF2-f)] and/or its derivative, wherein m is a natural number of 2 to 4; parameters a, b, c, d, e, f satisfy inequalities: 0.2≤a+b<0.75, a≠0, 0≤b, 0≤c≤3, 0≤d≤2, 2≤c+d≤3, 0≤e<4, and 0≤f≤2; E1 is an element of Mg, Al, Si, Sc, Ca, Cr, Sr, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Zr or Ba, and turning into a polyvalent cation between layers; E2 is an element of Na, Li or K, and turning into a monovalent cation between layers; M1 is an element of Mg, Fe, Mn, Ni, Zn or Li; M2 is an element of Al, Fe, Mn or Cr; and the M1 and M2 form an octahedral sheet. 2. The purine base adsorption material according to claim 1 , wherein the 2:1 type layered clay mineral is at least one smectite selected from the group consisting of montmorillonite claim 1 , beidellite claim 1 , nontronite claim 1 , saponite claim 1 , hectorite and stevensite.3. The purine base adsorption material according to claim 1 , wherein the parameters a and b satisfy 0.2≤a+b≤0.6.4. The purine base adsorption material according to claim 1 , wherein the parameter a satisfies 0.12≤a≤0.6.5. The purine base adsorption material according to claim 1 , wherein the E1 is at least one element selected from the group consisting of Mg claim 1 , Al claim 1 , Si claim 1 , Sc claim 1 , Ca claim 1 , Ti claim 1 , V claim 1 , Cr claim 1 , Mn claim 1 , Fe claim 1 , Ni claim 1 , Cu claim 1 , Ga and Zr.6. The purine base adsorption material according to claim 3 , wherein an occupied area per polyvalent cation E1 on a layer plane is in a range of no less than 0.8 nm/cation to no greater than 9 nm/cation.7. The purine base adsorption material according to claim 1 , wherein the 2:1 type layered clay mineral and/or its derivative may have a basal plane spacing of no less than 1.2 nm to no greater than 1.9 nm as measured by X-ray diffraction in a state wetted with water.8. The purine base adsorption material according to claim ...

Multi-capillary monolith made from amorphous silica and/or activated alumina

The invention relates to a monolithic porous material based on amorphous silica or activated alumina or on one of their mixtures, the material comprising substantially rectilinear capillary ducts that lie parallel to one another, and being intended to be used as packing in a chromatography column, characterised in that: the ducts have, relative to one another, a substantially uniform cross section; the cross-section of each duct is uniform over its entire length; the ducts pass right through the material; the volume of micropores smaller than 0.3 nm is smaller than 50% of the total porous volume of the material.

Multicapillary packing chromatography method

Chromatography method in which a gaseous, liquid or supercritical mobile phase containing species to be separated is circulated through a packing, said packing being characterized in that: it comprises a plurality of capillary ducts extending in the packing between an upstream face through which the mobile phase enters the packing and a downstream face through which the mobile phase leaves the packing—the material of the walls comprises a first population of connected pores, providing passages from one duct to the next enabling molecular diffusion to take place between adjacent ducts, pores having a mean diameter (d pore ) of greater than 2 times the molecular diameter of at least one species to be separated—the diameter of the ducts is less than 50 μm.

SILICA COMPOSITE MONOLITH AS A SOLID PHASE EXTRACTION MATERIAL

A silica monolith nested in a polymer sponge may be formed by applying a hydrolyzed mixture of siloxanes to a melamine-formaldehyde sponge, and may be used in methods of solid phase extraction. 1. A composite material comprising a silica monolith nested in a melamine-formaldehyde (MF) sponge.2. The composite material of comprising surface sulfonic groups.3. The composite material of comprising a surface cyclodextrin.4. A method of forming a composite material comprising a silica monolith nested in a polymer sponge claim 1 , comprising the step of applying a hydrolyzed mixture of tetramethoxysilane (TMOS) and vinyltrimethoxysilane (VTMS) to a melamine-formaldehyde (MF) sponge.5. The method of comprising the step of mixing a cyclodextrin to the hydrolyzed mixture.6. The method of comprising the further step of functionalizing the silica monolith with sulfonic groups.7. A method of extracting a bisphenol from a sample claim 3 , comprising the step of passing the sample through a composite material as claimed in .8. A method of extracting a peptide from a sample claim 2 , comprising the step of passing the sample through a composite material as claimed in .9. The method of wherein the peptide is a dipeptide. The present invention relates to a composite silica monolith nested in sponge (SiMNS), and the use of silica monolith in environmental studies.Solid phase extraction (SPE) is one of the most widely used techniques for sample preparation because of its capabilities to concentrate analytes at trace/ultra-trace levels for quantification and to remove matrix interference. A desirable SPE cartridge should provide efficient retention, selectivity, and a high capacity for target analytes. Existing SPE cartridges are mostly prepared by packing particle sorbents. Particle sizes of 30-105 μm are usually utilized to balance the diffusional mass-transfer of analytes and the back pressure of cartridges. However, large-size particles often create non-uniform packing and inter- ...

Cellular porous monoliths containing condensed tannins

A method for producing polyHIPE porous monoliths, of the polyHIPE type or in the form of a rigid foam, by hardening solutions of condensed tannins in the presence of oil and/or air or in the presence of a non-water-miscible volatile solvent and/or air. Also disclosed is the use of these materials in the areas of catalysis, chromatography, heat and sound insulation, tissue engineering and medication release and as a floral foam.

SYSTEM AND METHOD FOR SORBTION DISTILLATION

A system for distilling water is disclosed. The system comprises a heat source, and a plurality of open-cycle adsorption stages, each stage comprising a plurality of beds and an evaporator and a condenser between a first bed and a second bed, wherein each bed comprises at least two vapor valves, a plurality of hollow tubes, a plurality of channels adapted for transferring water vapor to and from at least one of the condenser or the evaporator, a thermally conductive water vapor adsorbent, and wherein each vapor valve connects a bed to either the condenser or the evaporator. 1. A method of distilling water , comprising the steps of:a. providing a plurality of stages, each stage comprising a hot adsorbent bed and a cold adsorbent bed, and each stage has an upper and lower operating temperature limit, the difference between the upper and lower operating temperature limit being less than about 20° C.; i. providing an external heat source to heat the hot bed of a first stage to a first temperature;', 'ii. desorbing water vapor from the hot bed of the first stage and flowing water vapor into a first condenser;', 'iii. condensing water vapor in the first condenser to form a liquid water and removing at least some of the liquid water from the first condenser;', 'iv. providing a solution comprising water and at least one dissolved impurity to a first evaporator, the solution having a temperature predetermined to suit the equilibrium uptake of an adsorbent, where a suitable temperature is predetermined by first selecting both a desired operational temperature range and uptake range for the adsorbent, then selecting the solution temperature such that the saturated water vapor partial pressure corresponds to the desired adsorbent temperature and uptake range;', 'v. transferring a forcing phase latent heat of vaporization from vapor condensing in the first condenser to the first evaporator to evaporate the solution comprising water and at least one dissolved impurity to form ...

CHROMATOGRAPHIC COMPOSITIONS

Provided herein are stationary phase compositions comprising a chromatographic surface of porous or non-porous core material comprising a surface modifier for use in chromatographic separations. 5. The stationary phase composition of claim 4 , wherein Ris trimethylsilyl.11. The stationary phase composition of claim 10 , wherein Ris trimethylsilyl.12. The stationary phase composition of claim 1 , wherein each b is 0 to 3.13. The stationary phase composition of claim 1 , wherein each b is 0.14. The stationary phase composition of claim 1 , wherein each a is 0 to 3.15. The stationary phase composition of claim 1 , wherein each a is 0.16. The stationary phase composition of claim 1 , wherein each x is 0 to 4.17. The stationary phase composition of claim 1 , wherein each x is 0.18. The stationary phase composition of claim 1 , wherein each y is 0 to 4.19. The stationary phase composition of claim 1 , wherein each y is 0.20. The stationary phase composition of claim 1 , wherein each Rand Rare independently aryl or (C-C)alkyl optionally substituted with cyano. This application claims benefit of and priority to U.S. Provisional Application Nos. 62/472,342 entitled “Chromatographic Compositions” filed Mar. 16, 2017, and 62/543,654 entitled “Chromatographic Compositions” filed Aug. 10, 2017, the contents of each of which are incorporated herein by reference in their entirety.The technology relates generally to chromatographic compositions. The invention relates more particularly, in various embodiments, to stationary phase compositions comprising a chromatographic surface of porous or non-porous core material comprising a surface modifier for use in chromatographic separations.Liquid chromatography (LC) combined with mass spectrometry (MS) is one of the most powerful analytical tools for the characterization of proteins. Indeed, for the analysis of biopharmaceuticals, reversed phase liquid chromatography (RPLC) coupled with MS is frequently relied upon for measuring intact ...

LAYERED SILICATE POWDER GRANULES AND METHOD FOR PRODUCING THE SAME

The invention has for its object to use an evaporation-spray drying process thereby providing layered silicate powder granules, each one containing a flat particle having an opening or recess in its surface center. Each of the layered silicate powder granule contains a flat particle including a layered silicate formed by evaporation-spray drying and a rheology modifier for modifying the crystal edge face of the layered silicate and having an opening or recess in its surface center. 1. A layered silicate powder granule comprising a flat particle , which comprises a layered silicate formed by evaporation-spray drying and a rheology modifier for modifying a crystal edge face of the layered silicate , and which has an opening or recess in its surface center.3. A layered silicate powder granule as recited in claim 1 , wherein the layered silicate is at least one selected from the group consisting of smectites claim 1 , swelling synthetic micas claim 1 , and vermiculites.4. A layered silicate powder granule as recited in claim 3 , wherein the smectites are selected from montmorillonite claim 3 , beidellite claim 3 , nontronite claim 3 , saponite claim 3 , hectorite and stevensite.5. A layered silicate powder granule as recited in claim 3 , wherein the swelling synthetic micas are selected from Na-tetrasilisic mica or Na-taeniolite.6. A layered silicate powder granule as recited in claim 3 , wherein the vermiculites are selected from dioctahedral type vermiculite or trioctahedral type vermiculite.7. A layered silicate powder granule as recited in claim 1 , wherein the rheology modifier is an anionic compound.8. A layered silicate powder granule as recited in claim 1 , wherein the rheology modifier is used in an amount of 1 to 20 parts by mass per 100 parts by mass of the layered silicate.9. A layered silicate powder granule as recited in claim 1 , wherein the flat particle has an outer diameter of greater than 500 nm and less than 50 mm as observed and measured under a ...

Methods For Extracting Constituents From Plant Material and Apparatus and Products Thereof

A closed loop extraction process contains a filter assembly for vacuum filtration of an extraction solvent after it has extracted desired constituents from a plant material. High purity products formed from the process are also provided. A closed loop extraction system contains a filter assembly for filtering an extraction solvent and extract prior to collection of desired products within a collection vessel . A filter assembly , used in the aforementioned process and system , provides a novel enhancement in the current strategies to extract active ingredients from plant materials 1. A product formed by a closed loop extraction process comprising the steps of:packing an extraction vessel with a plant material and sealing the extraction vessel;pumping an extraction solvent comprising a hydrocarbon-based solvent into the extraction vessel;retaining the extraction solvent within the extraction vessel for a predetermined amount of time to produce one or more extracts from the plant material within the extraction solvent;drawing or evacuating the extraction solvent from the extraction vessel into a filter under vacuum, wherein the filter comprises silica and is located immediately downstream and after the extraction vessel;filtering the extraction solvent containing the one or more extracts after retaining the extraction solvent within the extraction vessel;after filtration, drawing the extraction solvent into a collection vessel under vacuum; anddrawing the extraction solvent from the collection vessel to isolate the product in the collection vessel,wherein said closed-loop process is a cold solvent process.2. The product of wherein the hydrocarbon-based solvent is selected from the group consisting of iso-butane claim 1 , butane claim 1 , propane claim 1 , pentane claim 1 , and hexane.3. The product of wherein the hydrocarbon-based solvent is iso-butane.4. The product of wherein the process further comprises the step of:creating a vacuum throughout the system prior to ...

DIFLUOROACETIC ACID ION PAIRING REAGENT FOR HIGH SENSITIVITY, HIGH RESOLUTION LC-MS OF BIOMOLECULES AND SMALL MOLECULES

The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 2.50% (v/v) difluoroacetic acid and less than about 100 ppb of any individual impurity, especially metal impurities. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample. 1. A method of separating at least one small molecule from a sample , the method comprising:flowing a mobile phase through a chromatography column wherein the mobile phase comprises about 0.005% (v/v) to about 2.50% (v/v) difluoroacetic acid and less than about 100 ppb of any individual impurity;injecting a sample comprising the at least one small molecule into the mobile phase; andseparating the at least one small molecule from the sample.2. The method of claim 1 , wherein the chromatography column is a liquid chromatography column.3. The method of claim 1 , wherein the chromatography column is a HILIC chromatography column.4. The method of claim 1 , wherein the chromatography column is a mixed mode chromatography column.5. The method of claim 1 , wherein the chromatography column further comprises a stationary phase having a polymeric polystyrene divinyl benzene surface chemistry.6. The method of claim 1 , wherein the mobile phase comprises less than about 50 ppb of any individual impurity.7. The method of claim 1 , wherein the mobile phase comprises less than about 20 ppb of any individual impurity.8. The method of claim 1 , wherein the mobile phase comprises about 0.01% to about 0.9% difluoroacetic acid.9. The method of claim 1 , further comprising detecting the small molecule with a mass spectrometer.10. The method of claim 9 , further comprising generating small molecule ions.11. The method of claim 10 , wherein the small molecule ions are generated by ...

LOW SOLUBLE ARSENIC DIATOMITE FILTER AIDS

Low soluble arsenic diatomite filter aids and method of making such filter aids are disclosed. Alumina and/or aluminum hydroxide (ATH) are used as additives when preparing the filter aids, which may be straight-calcined or flux-calcined. Alternatively, activated alumina may be added to an already straight-calcined or flux-calcined diatomite filter aid. As compared to either straight-calcined or soda ash flux-calcined diatomite filter aids of similar permeabilities made from the same ore, the disclosed filter aids have lower soluble arsenic content. The disclosed filter aids have a soluble arsenic content, either by the OIV, EBC or USFCC method, of about 60% or less than the straight or flux-calcined diatomite filter aids of similar permeability without an alumina or ATH additive. 1. A straight-calcined diatomite filter aid comprising:diatomite;an aluminum additive selected from the group consisting of alumina and aluminum hydroxide (ATH); and an International Oenological Codex, by Organisation Internationale de la Vigne et du Vin (OIV), soluble arsenic content of less than about 3 ppm;', 'a European Brewing Convention (EBC) soluble arsenic content of less than about 10 ppm;', 'a United States Food Chemical Codex (USFCC) soluble arsenic content of less than about 10 ppm; and', 'combinations thereof., 'a soluble arsenic content as analyzed by a method selected from the group consisting of'}2. The straight-calcined diatomite filter aid of claim 1 , wherein the OIV soluble arsenic content is less than about 1 ppm.3. The straight-calcined diatomite filter aid of claim 1 , wherein the EBC soluble arsenic content is less than about 5 ppm.4. The straight-calcined diatomite filter aid of claim 1 , wherein the USFCC soluble arsenic content is less than about 5 ppm.5. The straight-calcined filter aid of wherein the aluminum additive is ATH claim 1 , which has a median particle diameter exceeding about 15 microns.6. The straight-calcined filter aid of wherein the aluminum ...

Method for recovering catalyst

A catalyst is recovered from an aqueous reaction mixture comprising heterocyclic nitroxyl catalyst and oxidized cellulose, by: —separating the oxidized cellulose from the reaction mixture, —contacting the reaction mixture with solid hydrophobic adsorbent particles with particle sizes below 350, preferably below 200 μm, more preferably below 100 μm, said particles being silica particles provided with functionnalized hydrophobicity, —adsorbing the catalyst to the hydrophobic adsorbent particles, and—eluting the catalyst from the adsorbent particles with an organic solvent.

SUPERFICIALLY POROUS PARTICLES WITH DUAL PORE STRUCTURE AND METHODS FOR MAKING THE SAME

Superficially porous particles are provided. Aspects of the superficially porous particles include a non-porous inner core and a porous outer shell that includes inner and outer porous regions. The inner porous region can include ordered cylindrical pores substantially perpendicular to the non-porous inner core. The outer porous region can include conical pores which extend to the surface of the particles and which are in fluid communication with the cylindrical pores of the inner porous region. Also provided are methods of making the subject superficially porous particles. Aspects of the methods include subjecting substantially solid inorganic oxide particles to agitation in an aqueous solution in the presence of a first cationic surfactant and a second anionic surfactant, which together form micelles, to pseudomorphically transform the particles. 1. Superficially porous particles , comprising:non-porous inner cores; and inner porous regions comprising ordered cylindrical pores substantially perpendicular to the non-porous inner cores, wherein the median cylindrical pore diameter is from about 15 to about 1000 Å;', 'outer porous regions comprising conical pores which extend to the surface of the particles and have a median conical pore size of about 150 to about 2500 Å, wherein the conical pores are in fluid communication with the cylindrical pores of the inner porous regions; and, 'porous outer shells, comprisingwherein the median conical pore size is larger than the median cylindrical pore size.2. The superficially porous particles of claim 1 , wherein the median conical pore diameter is at least 50% larger than the median cylindrical pore diameter.3. The superficially porous particles of claim 1 , wherein the median cylindrical pore diameter is from about 50 Å to about 800 Å.4. The superficially porous particles of claim 1 , wherein the median cylindrical pore diameter is from about 100 Å to about 300 Å.5. The superficially porous particles of claim 1 , wherein ...

Synthetic silica as packing material in supported liquid extraction

In embodiments, a packing material for supported liquid extraction has a sorbent media that includes synthetic silica particles. In embodiments, the synthetic silica particles can have physical properties relating to one or more of particle surface area, shape, size, or porosity. In one embodiment, synthetic silica particles have a surface area less than about 30 m 2 /g. In another embodiment, the synthetic silica particles have an approximately uniform particle shape. In further examples, synthetic silica particles have a particle size in a range of about 30-150 μm inclusive or greater than about 200 μm. In another embodiment, synthetic silica particles are arranged to have a pore size greater than about 500 Angstroms. In an embodiment, an apparatus for supported liquid extraction includes a container and a sorbent media that includes synthetic silica particles. In a further embodiment, a method for extracting target analytes through supported liquid extraction is provided.

SURFACE MODIFICATION OF POROUS BASE SUPPORTS

The present invention relates to new separation materials with improved binding capacity, its manufacturing, and application, especially for binding protein A. 1. Separating materials for affinity chromatography based on hydroxyl-containing porous base supports , to the surfaces of which polymer chains are grafted by covalent bonding , characterised in thata) two or more grafted polymer chains are initiated from one hydroxyl group on the surface, andb) each polymer chain has multiple derivatizable groups for coupling affinity ligands.2. Separating materials according to characterised in that the porous base support is a porous ceramic medium.3. Separating materials according to characterised in that the porous base support is a porous ceramic medium comprising oxides of silicium claim 1 , zirconium titanium claim 1 , their mixtures.4. Separating materials according to characterised in that the porous base support is a silica based porous medium.5. Separating materials according to characterised in that the porous base support is a silica based porous medium claim 1 , which is coated with zirconia or titanium oxide.6. Separating materials according to characterised in that the porous base support is a porous polymer support having hydroxyl groups at the surface.76. Separating material according any one of the claims 1 , to claims 1 , comprising a porous base support which is first treated with a tri- or more functional epoxide.87. Separating material according to one or more of the preceding - wherein the porous base support is first treated with a tri- or more functional epoxide forming a crosslinked coating rich in epoxy functionality.98. Separating material according to any one of the claims 1 , to comprising a porous base support covered with a crosslinked coating rich in aliphatic hydroxyl or diol groups for covalent bonding of graft polymer chains comprising acrylic acid or its derivative providing carboxylic acid groups.108. Separating material according to ...

Methods of determining the mineralogy of calcined and flux-calcined diatomite

A method of determining opal-C and cristobalite contents of a product that comprises diatomite is disclosed. The method may comprise performing thermal processing to determine a loss on ignition for a representative first portion of a sample of the product; identifying and quantifying primary and secondary peaks present in a first diffraction pattern that results from bulk powder X-ray Diffraction on a representative second portion of the sample; and using a known standard sample of cristobalite to determine whether the primary and secondary peaks present in the first diffraction pattern indicate the presence of opal-C or cristobalite in the product.

CHROMATOGRAPHY COLUMN WITH LOCKED PACKED BED AND METHOD OF PACKING THAT COLUMN

A chromatography column has a retaining plug permanently fixed to an upstream end of the column and blocks one end of the bore through the column. The plug has a fluid passage therethrough. An upstream end of the passage is preferably but optionally larger in diameter than a downstream end of the passage. An upstream porous member upstream of the retaining plug is held by an upstream end cap and urged toward the plug. Chromatographic media extends from the upstream porous member, through the passage in the retaining plug, to a downstream porous member held by a downstream end cap. The media between the retaining plug and the downstream porous member are under compression to form a bed of packed media.

MULTI-CAPILLARY MONOLITH MADE FROM AMORPHOUS SILICA AND/OR ACTIVATED ALUMINA

The invention relates to a monolithic porous material based on amorphous silica or activated alumina or on one of their mixtures, the material comprising substantially rectilinear capillary ducts that lie parallel to one another, and being intended to be used as packing in a chromatography column, characterised in that: 1. A method for producing a packing comprising a monolithic porous material based on a combination including amorphous silica and activated alumina and comprising substantially rectilinear capillary channels parallel to one another , the method comprising the steps of:providing a bundle of so-called precursor fibres of the channels for which the diameter is equal to that of the capillary channels,forming a porous matrix around fibres based on a combination including amorphous silica and activated alumina,eliminating the fibres so as to form in said matrix, said capillary channels.2. The method of claim 1 , wherein the elimination of the fibres is achieved through lumens or interstices left free between the juxtaposed fibres of the bundle.3. The method of claim 1 , wherein the formation of a mineral solid porous matrix around the fibers is ensured by a sole gel method.4. The method of claim 1 , wherein the material is reinforced by depositing silica at the surface of the particles making it up before drying. The present invention concerns a monolithic porous material of amorphous silica or activated alumina, or one of their combinations, comprising substantially rectilinear capillary channels that are parallel to one another, passing through the material from end to end and intended in particular for use in chromatography.The close contact between two phases such as a gas and a liquid to promote their chemical or physical interaction is an important operation in chemical engineering.To promote interface phenomena on the contact surface between these two phases, it is endeavoured to increase this contact surface as much as possible, and to increase the ...

Synthetic Silica as Packing Material in Supported Liquid Extraction

In embodiments, a packing material for supported liquid extraction has a sorbent media that includes synthetic silica particles. In embodiments, the synthetic silica particles can have physical properties relating to one or more of particle surface area, shape, size, or porosity. In one embodiment, synthetic silica particles have a surface area less than about 30 m/g. In another embodiment, the synthetic silica particles have an approximately uniform particle shape. In further examples, synthetic silica particles have a particle size in a range of about 30-150 μm inclusive or greater than about 200 μm. In another embodiment, synthetic silica particles are arranged to have a pore size greater than about 500 Angstroms. In an embodiment, an apparatus for supported liquid extraction includes a container and a sorbent media that includes synthetic silica particles. In a further embodiment, a method for extracting target analytes through supported liquid extraction is provided. 1. A packing material for supported liquid extraction , comprising:{'sup': '2', 'a sorbent media that includes synthetic silica particles having a surface area less than about 30 m/g.'}2. The packing material of claim 1 , wherein the synthetic silica particles have an approximately uniform particle shape.3. The packing material of claim 2 , wherein the approximately uniform particle shape comprises at least one of an approximately rounded shape claim 2 , or an approximately spherical shape having an approximately uniform diameter across a distribution of the particles.4. The packing material of claim 1 , wherein the synthetic silica particles have a particle size in a range of about 30-150 μm inclusive.5. The packing material of claim 1 , wherein the synthetic silica particles have a particle size greater than about 200 μm.6. The packing material of claim 1 , wherein the synthetic silica particles are arranged to have a pore size greater than about 500 Angstroms.7. An apparatus for supported liquid ...

THIN LAYER CHROMATOGRAPHY PLATES

In an embodiment, a method for manufacturing a thin layer chromatography (“TLC”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), priming the elongated nanostructures with one or more adhesion priming layers, and at least partially coating the elongated nanostructures with a coating. The coating includes a stationary phase and/or precursor of a stationary phase for use in chromatography. The stationary phase may be functionalized with hydroxyl groups by exposure to a base or acid. The stationary phase may further be treated with a silane (e.g., an amino silane) to improve the performance of the TLC plate. Embodiments for TLC plates and related methods are also disclosed. 1. A thin layer chromatography plate , comprising:a substrate;one or more residual priming adhesion layers disposed over the substrate;a plurality of stationary phase structures extending longitudinally away from the substrate, at least a portion of the plurality of stationary phase structures exhibiting an elongated geometry and being substantially free of carbon nanotubes; anda plurality of silanol groups bonded to the plurality of stationary phase structures.2. The thin layer chromatography plate of claim 1 , further comprising a plurality of hydroxyl groups bonded to the plurality of stationary phase structures.3. The thin layer chromatography plate of wherein each of the plurality of stationary phase structures includes at least one of a stationary phase or a precursor of the stationary phase.4. The thin layer chromatography plate of wherein the stationary phase or the precursor of the stationary phase includes at least one of elemental silicon claim 3 , silicon dioxide claim 3 , silicon nitride claim 3 , elemental aluminum claim 3 , aluminum oxide claim 3 , elemental zirconium claim 3 , zirconium oxide claim 3 , elemental titanium claim 3 , titanium oxide claim 3 , amorphous carbon claim 3 , graphitic carbon claim 3 , or combinations ...

CHROMATOGRAPHIC MATERIALS

In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)(Q)(T)(Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0. 262-. (canceled)64. The chromatographic stationary phase material of claim 1 , wherein the chromatographic stationary phase material is in the form of a plurality of particles.65. The chromatographic stationary phase material of claim 1 , wherein the chromatographic stationary phase material is in the form of a monolith.66. The chromatographic stationary phase material of claim 1 , wherein the chromatographic stationary phase material is in the form of a superficially porous material.67. The chromatographic stationary phase material of claim 1 , wherein the chromatographic stationary phase material has chromatographically enhancing pore geometry.68. The chromatographic stationary phase material of claim 64 , wherein the plurality of particles have sizes between about 1.5 and 5 microns.69. The chromatographic stationary phase material of claim 1 , wherein the chromatographic stationary phase material has a surface area of about 25 to 1100 m/g.70. The chromatographic stationary phase material of claim 1 , wherein the chromatographic stationary phase material has a pore volume of about 0.2 to 2.0 cm/g.71. The ...

Method for measuring polymer modification ratio

The present invention relates to a method for measuring a polymer modification ratio, and more particularly, to a method for measuring a polymer modification ratio, which includes preparing a first solution by dissolving a polymer mixture containing a modified polymer and an unmodified polymer in a first solvent, injecting the first solution into a column filled with an adsorbent, adsorbing the modified polymer onto the adsorbent, and eluting the first solution in which the unmodified copolymer is dissolved, transferring the eluted first solution to a detector, injecting a second solvent into the column to elute the second solution in which the adsorbed modified polymer is dissolved, and transferring the eluted second solution to the detector.

FUNCTIONALIZED PARTICLES HAVING MODIFIED PHASES

Modified silica particles are provided. Aspects of the particles include an outer layer that is composed of organically-modified silica comprising a siloxane-linked hydrophilic group, such as a charged functional group or a polar neutral functional group. The modified silica particles can form the basis of a variety of chromatography support materials. Also provided are methods of preparing the subject particles. Aspects of the methods include contacting silica particles with water, an ionic fluoride and an organosilane reagent comprising a hydrophilic moiety to produce modified silica particles wherein the hydrophilic moiety of the organosilane reagent is incorporated into an outer layer of the silica particles. Chromatography supports and kits including the subject particles and methods of using the same are also provided. 2. The particle of claim 1 , wherein the hydrophilic moiety is selected from a nitrogen-containing hetereocycle claim 1 , amide claim 1 , carbamate claim 1 , carboxylic acid claim 1 , carboxy ester claim 1 , methyl ether claim 1 , cyano claim 1 , amine claim 1 , ammonium claim 1 , sulfonamide claim 1 , sulfonate claim 1 , urea claim 1 , thiourea claim 1 , hydroxyl claim 1 , thiol claim 1 , PEG claim 1 , a zwitterionic group claim 1 , and sulfonic acid.3. The particle of claim 1 , wherein the hydrophilic moiety is a charged moiety.4. The particle of claim 1 , wherein:{'sup': '1', 'sub': 2', '2', '3, 'when the siloxane-linked hydrophilic group is of formula (Ib), Lis a C1-C6 alkyl and Z is selected from 2-pyridyl, 3-pyridyl, 4-pyridyl, —CONH, —OCONHMe, —NHCOOMe, NHCONH, —OMe, CN and SOH;'}{'sup': 1', '2', '1', '2, 'when the siloxane-linked hydrophilic group is of formula (IIb), Land Lare each independently a C1-C6 alkyl, wherein the combined length of Land Lis 10 carbons or less, and Z is selected from —O— and —NR′—, wherein R′ is H, an alkyl or a substituted alkyl; and'}{'sup': 1', '2', '3', '1', '2, 'sub': 2', '2', '3, 'when the siloxane-linked ...

CHROMATOGRAPHIC MATERIALS FOR THE SEPARATION OF UNSATURATED MOLECULES

The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group. 130-. (canceled)32. The method of claim 31 , wherein the compound of interest is a lipid claim 31 , vitamin claim 31 , or polycyclic aromatic hydrocarbon.33. The method of claim 32 , wherein the lipid is a saturated or an unsaturated fatty acid claim 32 , monoacylglyceride claim 32 , diacylglyceride claim 32 , triacylglyceride claim 32 , phospholipid claim 32 , sphingolipid or steroid.34. The method of claim 32 , wherein the vitamin is a water soluble vitamin selected from the group consisting of vitamin C claim 32 , vitamin B claim 32 , or derivatives or combinations thereof.35. The method of claim 32 , wherein the vitamin is a fat soluble vitamin selected from the group consisting of vitamin A claim 32 , vitamin D claim 32 , vitamin K claim 32 , vitamin E claim 32 , betacarotene claim 32 , or derivatives or combinations thereof.36. The method of claim 31 , wherein the chromatographic stationary phase is adapted for supercritical fluid chromatography.37. The method of claim 31 , wherein the chromatographic stationary phase is adapted for carbon dioxide based chromatography.38. A method for mitigating or preventing retention drift in normal phase chromatography claim 31 , high-pressure liquid chromatography claim 31 , solvated gas chromatography claim 31 , ...

Porous inorganic/organic hybrid particles having high organic content and enhanced pore geometry for chromatographic separations

Novel particles and materials for chromatographic separations, processes for preparation and separations devices containing the chromatographic particles and materials are provided by the instant invention. In particular, the invention provides a porous inorganic/organic hybrid particle, wherein the inorganic portion of the hybrid particle is present in an amount ranging from about 0 molar % to not more than about 49 molar %, wherein the pores of the particle are substantially disordered. The invention also provides a porous inorganic/organic hybrid particle, wherein the inorganic portion of the hybrid particle is present in an amount ranging from about 25 molar % to not more than about 50 molar %, wherein the pores of the particle are substantially disordered and wherein the particle has a chromatographically enhancing pore geometry (CEPG). Methods for producing the hybrid particles, separations devices comprising the hybrid particles and kits are also provided.

SUPERFICIALLY POROUS MATERIALS COMPRISING A SUBSTANTIALLY NONPOROUS HYBRID CORE HAVING NARROW PARTICLE SIZE DISTRIBUTION

The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are chromatographic materials comprising having a narrow particle size distribution. 211-. (canceled)12. The superficially porous material of claim 1 , wherein the superficially porous material has chromatographically enhancing pore geometry.1318-. (canceled)19. The superficially porous material of claim 1 , wherein the porous shell material is a porous inorganic/organic hybrid material.20. The superficially porous material of claim 1 , wherein the porous shell material is a porous silica.21. The superficially porous material of claim 1 , wherein the porous shell material is a porous composite material.22. The superficially porous material of claim 1 , wherein the superficially porous particles comprise an inorganic/organic hybrid core and more than one layer of a porous shell material wherein each layer of the porous shell material is independently selected from a porous inorganic/organic hybrid material of formula (II) according to claim 1 , a porous silica claim 1 , a porous composite material or mixtures thereof.2326-. (canceled)27. The superficially porous material of claim 1 , wherein the superficially porous material has a spherical core morphology claim 1 , a rod shaped core morphology claim 1 , a bent-rod shaped core morphology claim 1 , a toroid shaped core morphology claim 1 , or a dumbbell shaped core morphology.2838-. (canceled)39. The superficially porous material of claim 1 , wherein the inorganic/organic hybrid core has a particle size of 0.5-10 μm.40. (canceled)41. (canceled)42. The superficially porous material of claim 1 , wherein the superficially porous particles comprise an inorganic/ ...

Separating Agent for Chromatography, Chromatography Column, and Method for Separation by Chromatography

The present invention provides a chromatographic separating agent which exhibits excellent performances in separation of organic compounds, such as reducing sugars without formation of Schiff bases and anomer separation in analysis of saccharides. The chromatographic separating agent includes a porous substrate surface-modified with silane functional groups represented by the formula: 2. The chromatographic separating agent according to claim 1 , wherein Ris —(CH)— wherein m is 1 to 10.3. The chromatographic separating agent according to claim 1 , wherein Rand Rare independently —(CH)— wherein n is 1 to 6.4. The chromatographic separating agent according to claim 1 , wherein Ris —(CH)— and Rand Rare —(CH)—.5. The chromatographic separating agent according to claim 1 , wherein the porous substrate is at least any one selected from the group consisting of porous inorganic particles claim 1 , a porous inorganic bulk body claim 1 , porous polymer particles claim 1 , and a porous polymer bulk body.6. The chromatographic separating agent according to claim 1 , wherein the porous substrate is porous inorganic particles or a porous inorganic bulk body claim 1 , the porous inorganic particles or porous inorganic bulk body being silica gel.7. A chromatographic column comprising:a cylindrical column body; and{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the chromatographic separating agent of packed or formed in the column body.'}8. A chromatographic separating method comprising the step of separating a plurality of substances using the chromatographic separating agent of .9. The separating method according to claim 8 , wherein at least one of the plurality of substances is saccharide. The present invention relates to a chromatographic separating agent, a chromatographic column, and a chromatographic separating method.Chromatographic separating agents are materials packed or formed in a chromatographic column to serve as stationary phases. Silica gel is a commonly used ...

MONOLITHIC BODY

The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body. 124.-. (canceled)25. A process for separating an analyte from a radioactive sample , comprising:eluting the sample through a chromatographic monolithic body,wherein the monolithic body is an inorganic monolithic body and is part of a microfluidic flow system.27. (canceled)28. A process for the manufacture of a monolithic module , comprising:i) supplying a mould for injection moulding containing an inorganic monolithic body;ii) injecting liquid polymer into the mould wherein the liquid polymer flows between a surface of the mould and a surface of the monolithic body and surrounds the monolithic body;iii) setting the polymer to form the monolithic module;iv) optionally annealing the monolithic module; andv) optionally providing an inlet and/or outlet, for example by machining the monolithic module.2930-. (canceled)31. The process according to claim 28 , further comprising:ii) injecting liquid polymer into the mould wherein the liquid polymer flows between a surface of the mould and a surface of the monolithic body and surrounds the monolithic body, except for the area of contact between the mould and monolithic body;iii) prior to setting the polymer to form the monolithic module, setting the polymer to form a partial monolithic module;iv) prior to setting the polymer to form the monolithic module, inserting the partial monolithic mould into a second mould for injection moulding; andv) prior to setting the polymer to form the monolithic module, injecting liquid polymer into the second mould wherein the liquid polymer flows between a surface of the mould and an exposed surface of the monolithic body to ...

GC COLUMN FERRULES HAVING FIRST AND SECOND DEFORMABLE SURFACES

A capillary column includes a fused silica tubing, a polyimide coating over the fusing silica tubing, and a first plurality of integrated ferrules positioned along at least a first portion of the fused silica tubing and spaced apart from one another by a first fixed interval. Each of the first plurality of integrated ferrules includes a first deformable surface and a second deformable surface. The first plurality of integrated ferrules are secured to the column through deformation of the first deformable surface and the second deformable surface is configured to form a seal with a junction when secured with a nut. 1. A capillary column comprising:a fused silica tubing;a polyimide coating over the fused silica tubing; anda first plurality of integrated ferrules positioned along at least a first portion of the fused silica tubing and spaced apart from one another by a first fixed interval, each of the first plurality of integrated ferrules including a first deformable surface and a second deformable surface, the first plurality of integrated ferrules secured to the column through deformation of the first deformable surface, the second deformable surface configured to form a seal with a junction when secured with a nut.2. The capillary column of wherein the first fixed interval is not less than an insertion depth.3. The capillary column of wherein the first plurality of integrated ferrules are oriented in a first direction and first portion of the fused silica tubing is located at or near a first end of the capillary column claim 1 , and further comprising a second plurality of integrated ferrules positioned along a second portion of the fused silica tubing and spaced apart from one another by a second fixed interval claim 1 , the second portion of the fused silica tubing located at or near a second end of the capillary column.4. The capillary column of wherein the first fixed interval is greater than the second fixed interval.5. The capillary column of wherein the ...

ISOLATION AND ANALYSIS OF TERPENES

In accordance with embodiments of the present invention, a terpene-rich sample is prepared for terpene analysis using liquid chromatography via an extraction method that takes little time, uses minimal external equipment, and permits direct injection of extracted terpenes into a liquid chromatography instrument for analysis. An embodiment of the invention involves preparing a terpene-containing sample for analysis by liquid chromatography by liquid extraction; heating the liquid extract in a vial that contains a filter medium or solvent; collecting the terpenes in the medium by the vapor pressure forced through the filter from heating; and eluting the collected terpenes into a vial or directly into a chromatography injector. 1. A method of analyzing terpenes in a sample , the method comprising the steps of:a. weighing and preparing the sample for extraction;b. adding, to a container, the sample and an extraction solvent;c. agitating the vial;d. heating the sample to force terpenes and the extraction solvent through a collection filter having therein a medium that preferentially binds terpenes; ande. eluting bound terpenes from the medium for analysis.2. The method of claim 1 , wherein the sample is weighed in the container.3. The method of claim 2 , wherein the sample is weighed in a component within the container.4. The method of claim 1 , further comprising the step of analyzing the eluted terpenes by liquid chromatography.5. The method of claim 4 , wherein the terpenes are eluted from the medium and injected into a chromatography instrument in a single step.6. The method of claim 5 , wherein airtight fluid communication is established between the medium and an inlet to the chromatography instrument.7. The method of claim 1 , wherein the medium is a reverse-phase chromatography material.8. The method of claim 6 , wherein the medium is C8 or C18.9. The method of claim 1 , wherein the medium is activated carbon.10. The method of claim 1 , wherein the medium is ...

Porous Silica Particles

The present disclosure provides a porous silica having an average pore diameter of at least 210 Å and a pore volume of at least 0.80 cmg. The present disclosure also provides a method of producing the porous silica including gelling a liquid phase-dispersed nanoparticulate silica in the presence of either (i) a Brønsted acid and an amine group having two or more primary or secondary amine groups or (ii) an amino acid. 1. A porous silica having an average pore diameter of at least 210 Å and a pore volume of at least 0.80 cmg.2. The porous silica as set forth in claim 1 , wherein the average pore diameter is up to 500 Å and/or the pore volume is up to 1.2 cmg.3. The porous silica as set forth in claim 1 , wherein one or more of the following conditions apply:{'sup': 3', '−1, '(i) the pore volume is at least 0.84 cmg;'}{'sup': 3', '−1, '(ii) the pore volume is up to 1.0 cmg;'}(iii) the average pore diameter is at least 250 Å;(iv) the average pore diameter is up to 450 Å;{'sup': 2', '−1, '(v) the porous silica has a specific surface area of from 50 to 500 mg;'}(vi) the porous silica has a surface modified with one or more organic groups;(vii) the porous silica has a pore size distribution of from 0.10 to 2.30; and(viii) the porous silica is in solid form.4. A process for producing a porous silica having an average pore diameter of at least 210 Å and a pore volume of at least 0.80 cmg claim 1 , the process comprising the step of gelling a liquid phase-dispersed nanoparticulate silica in the presence of either (i) a Brønsted acid and an amine compound having two or more amine groups selected from primary amine groups and secondary amine groups or (ii) an amino acid.5. The process as set forth in claim 4 , wherein the nanoparticulate silica has primary particles having an average diameter of from 2 to 200 nm claim 4 , and/or the liquid-phase dispersion of nanoparticulate silica is a water-in-oil emulsion or dispersion with the aqueous phase comprising the nanoparticulate ...

Porous silica particles

The present disclosure provides a porous silica having an average pore diameter of from 20 to 450 Å, a median (D50) pore diameter of from 20 to 450 Å, a pore volume of from 0.15 to 1.2 cm 3 g −1 , a surface area of from 100 to 600 m 2 g −1 , and a span of 0.80 or less. The present disclosure also provides a method of producing the porous silica. The method includes the step of mixing together an aqueous phase comprising nanoparticulate silica and an organic phase to form a water-in-oil dispersion or emulsion. The organic phase includes an organic solvent that is insoluble or partially soluble in water and optionally also includes a non-polar organic compound that is insoluble in water and at least partially soluble in the organic solvent. A gelling agent is present in the aqueous phase such that the nanoparticulate silica gels form the porous silica.

ANALYTICAL METHOD FOR SUGAR CHAINS HAVING ACIDIC GROUPS

A chromatography column for the use of separation of acidic sugar chains, wherein the column comprises a first column and a second column, the second column connected by a flow path downstream of an outlet of the first column, and selected from the following (1) or (2): (1) the carrier of the first column is hydrophobically modified silica having a group containing a primary amine, a secondary amine or/and a tertiary amine, and the carrier of the second column is a resin having a group containing a primary amine, a secondary amine or/and a tertiary amine; (2) the carrier of the first column is a resin having a group containing a primary amine, a secondary amine or/and a tertiary amine, and the carrier of the second column is hydrophobically modified silica having a group containing a primary amine, a secondary amine, or/and a tertiary amine. 1. A chromatography column comprising:a first column having an outlet; anda second column connected downstream of the outlet of the first column,wherein the first column and the second column satisfy either (1) or (2):(1) the first column includes a carrier 1 which is hydrophobically modified silica having a group including at least one of a primary amine, a secondary amine and a tertiary amine, and the second column includes a carrier 2 which is a resin having a group including at least one of a primary amine, a secondary amine and a tertiary amine; or(2) the first column includes the carrier 2, and the second column includes the carrier 1.2. The chromatography column according to claim 1 , wherein the first column and the second column are hydrophilic interaction chromatography columns.3. The chromatography column according to claim 1 , wherein the carrier 2 is an anion exchange resin.5. The chromatography column according to claim 1 , wherein the carrier 2 has an amino group of formula III claim 1 , {'br': None, 'sub': 2', '2', 'n, 'Y—NH(CHCHNH)H'}, 'formula III'}where Y represents a resin portion of the carrier 2, and n is ...

Porous monodisperse SiO¶2¶ particles

The invention relates to monodispersed, porous, spherical particles substantially consisting of SiO2 with an average particle diameter d50 of 0.05 to 10 mu m, a particle-diameter standard deviation of at most 15 %, and a pore width of 2-20 nm (20-200 ANGSTROM ), and methods for the production thereof.

Superficially porous materials comprising a substantially nonporous hybrid core having narrow particle size distribution; process for the preparation thereof; and use thereof for chromatographic separations

The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are chromatographic materials comprising having a narrow particle size distribution.

Process For Manufacturing a Composite Sorbent Material For Chromatographical Separation of Biopolymers

The present invention relates to a sorbent material for separation and purification of biopolymers, particularly nucleic acids, having a solid support substantially modified with a copolymer coating comprising aromatic monomers and crosslinking compounds and unsaturated esters or ethers preferably attached to the support via a vinylchlorsilane. The use of these materials for separation of nucleic acids, particularly a one-step isolation of DNA from lysates of different biological sources, is an object of the invention as well as a chromatographic column or cartridge at least partially filled with the sorbent material of the invention, a membrane-like device comprising the sorbent material of the invention, and a kit comprising the sorbent material of the invention in bulk or packed in chromatographic devices as well as other devices necessary for performing sample preparations.

Process for manufacturing a composite sorbent material for chromatographical separation of biopolymers

The present invention relates to a sorbent material for separation and purification of biopolymers, particularly nucleic acids, having a solid support substantially modified with a copolymer coating comprising aromatic monomers and crosslinking compounds and unsaturated esters or ethers preferably attached to the support via a vinylchlorsilane. The use of these materials for separation of nucleic acids, particularly a one-step isolation of DNA from lysates of different biological sources, is an object of the invention as well as a chromatographic column or cartridge at least partially filled with the sorbent material of the invention, a membrane-like device comprising the sorbent material of the invention, and a kit comprising the sorbent material of the invention in bulk or packed in chromatographic devices as well as other devices necessary for performing sample preparations.