Microchemical nanofactories

Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement synthetic processes, disclosed embodiments of the apparatus generally include at least one unit operation, such as a mixer, a valve, a separator, a detector, and combinations thereof. Individual apparatuses may be coupled both in series and in parallel to form a system for making chemical compounds. An individual apparatus or a system also can be used in combination with known devices and processes.

APPARATUS FOR MANUFACTURING PARTICLES AND METHOD FOR MANUFACTURING PARTICLES USING THE SAME

Apparatus for manufacturing particles has at least one reactor and a method for manufacturing particles using the same. A first reactor has a hollow main body extending in the lengthwise direction, first and second raw material inlets formed at the one side end of the main body, a reactant outlet formed at the other side end of the main body, and a mixer formed inside the main body to mix materials fed from the first and second raw material inlets. A second reactor of the apparatus connected to one side of the first reactor has a non-revolving hollow cylinder extending in the lengthwise direction, a revolving body extending in the lengthwise direction, a driver portion, a reactant inlet formed on the outer circumference at one side end of the cylinder and connected to the reactant outlet of the first reactor. 16-. (canceled)7. Apparatus for manufacturing particles , comprising:at least one first reactor comprising a hollow main body extending in a lengthwise direction, first and second raw material inlets formed at a first side end of the hollow main body to open into the hollow main body, a reactant outlet formed at a second side end of the hollow main body to open into the hollow main body, and a mixer formed inside of the hollow main body to mix materials fed from the first and second raw material inlets;a second reactor, connected to one side of said at least one first reactor, comprises a non-revolving hollow cylinder extending in a lengthwise direction, a revolving body extending in a lengthwise direction and configured in the second reactor to separate from an inner wall of the non-revolving hollow cylinder, a driver portion connected to one side end of the revolving body to rotate the revolving body, a reactant inlet formed on an outer circumference at a first side end of the non-revolving hollow cylinder in a lengthwise direction of the non-revolving hollow cylinder to open into the non-revolving hollow cylinder and connected to the reactant outlet of said ...

Modular flow reactor

A modular flow reactor is formed of a plurality of modules, wherein each module comprises a body having at least one conduit passing therethrough, and wherein a plurality of said modules are aligned along a longitudinal axis such that said conduits of said modules are aligned to form a passage for fluid, wherein each module has a length along said longitudinal axis which is less than the length of the module perpendicular to the longitudinal axis. The modules are “slices” rather than “tubes” and a plurality of said modules can be aligned linearly so that the conduits form a tube.

System and Method for Controlled Manufacturing of Mono-Disperse Microbubbles

The present invention is related to a system and method for controlled manufacturing of mono-disperse microbubbles. According to the invention, the mono-disperse nature of the collection of generated microbubbles can be improved by releasing the pressurized gaseous medium used in the system using release valve units. This further allows the system to be embodied as a portable system. In turn, the operator of an ultrasound imaging apparatus may use the system according to the invention to generate microbubbles on a patient-by-patient basis. 1. A system for controlled manufacturing of microbubbles , comprising:a microbubble generation unit having a first inlet for receiving a dispersed phase fluid, a second inlet for receiving a continuous phase fluid, and a bubble formation channel in which microbubbles are generated using the received dispersed phase fluid and the received continuous phase fluid, wherein the bubble formation channel has a width in the range of 15-35 micrometer, and a height in the range of 10-30 micrometer;a liquid pressurization unit having an inlet for receiving a second pressure regulated gaseous medium from a source of said second pressure regulated gaseous medium and being configured for outputting a flow of a pressurized liquid to the second inlet of the microbubble generation unit in dependence of a flow and/or pressure of the received second pressure regulated gaseous medium, wherein the first inlet of the microbubble generation unit is connected to a source of a first pressure regulated gaseous medium;a first release valve unit arranged in between the source of the first pressure regulated gaseous medium and the first inlet of the microbubble generation unit and being configured for releasing the first pressure regulated gaseous medium;a second release valve unit arranged in between the source of the second pressure regulated gaseous medium and the inlet of the liquid pressurization unit and being configured for releasing the second ...

AUTOMATED METHOD AND SYSTEM FOR RECOVERING PROTEIN POWDER MEAL, PURE OMEGA 3 OIL AND PURIFIED DISTILLED WATER FROM ANIMAL TISSUE

The present invention describes a method and an automatic system for recovering protein powder meal, crude and pure omega-3 oil and purified distilled water from a mixture of animal tissue processed in a filter-drier-reaction tank. Animal tissue, for example fish, and organic solvent are directly or indirectly fed into the filter-drier-reaction tank. The filter-drier-reaction tank mixes, heats, and separates solid and heavy liquid portions of the mixture, the organic solvents are automatically recycled back in to the system after distillation. The solid portion is retained in the filter-drier-reaction tank and baked. Solid protein powder product (the protein powder meal) is thus recovered. 125.-. (canceled)26. A protein product , wherein said protein product:a) is non-hygroscopic;b) comprises non-degraded protein;c) comprises a complete aminogram; andd) comprises 90-95% of protein by weight.27. The protein product of claim 26 , wherein the protein product is in a powder form.28. The protein product of claim 26 , wherein the protein product is in a granular form.29. The protein product of claim 26 , wherein the protein product has a 10 year shelf life.30. The protein product of claim 26 , wherein the protein product is suitable for human consumption.31. The protein product of claim 26 , wherein the protein product does not support bacterial growth.32. The protein product of claim 26 , wherein the protein product is sterile.33. The protein product of claim 26 , wherein the protein product comprises non-degraded protein extracted from an aquatic animal or part thereof.34. The protein product of claim 33 , wherein the aquatic animal or part thereof is a whole fish.35. The protein product of claim 26 , wherein the protein product has no noticeable odor or smell.36. The protein product of claim 26 , wherein the protein product comprises non-degraded organoleptic peptides.37. The protein product of claim 26 , wherein the protein product comprises no more than 1.5% of crude ...

Apparatus having a multitude of particles and method for manufacturing the same

An apparatus includes a substrate having a recess and a multitude of particles arranged in the recess. A first portion of the particles is joined to a porous structure by means of a coating. A second portion of the particles is not joined by means of the coating. The first portion of the particles is arranged closer to an opening of the recess than the second portion of the particles so that a leaking of the second portion of the particles from the recess through the opening is prevented.

Techniques for Photocatalytic Hydrogen Generation

Techniques for photocatalytic hydrogen generation are provided. In one aspect, a hydrogen producing cell is provided. The hydrogen producing cell includes an anode electrode; a photocatalytic material adjacent to the anode electrode; a solid electrolyte adjacent to a side of the photocatalytic material opposite the anode electrode; and a cathode electrode adjacent to a side of the solid electrolyte opposite the photocatalytic material. A solar hydrogen producing system including at least one solar concentrating assembly having the hydrogen producing cell, and a method for producing hydrogen using the hydrogen producing cell are also provided.

DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid. 115.-. (canceled)16. A system comprising:a microfluidic device comprising a substrate having a plurality of traps in fluidic communication with a channel, each trap comprises an opening along a side of the channel shaped and/or sized to accommodate a partition of a sample fluid within; anda detector to detect, monitor, or analyze each partition of sample fluid retained within a corresponding trap, the detector to detect emissions from one or more detectable markers associated with a target molecule in response to the occurrence of a polymerase-chain reaction (PCR) reaction in one or more partitions of sample fluid.17. The system of claim 16 , further comprising a plurality of partitions of sample fluid positioned within the plurality of traps in response to flow of an immiscible fluid through the channel.18. The system of claim 17 , wherein each of the plurality of partitions of sample fluid is at least partially surrounded by the immiscible fluid.19. The system of claim 18 , wherein each of the plurality of partitions of sample fluid is separated from one another and retained within a respective trap via the immiscible fluid positioned over the opening of each trap.20. The system of claim 17 , wherein the immiscible fluid is an oil.21. The system of claim 16 , wherein the target molecule is a biological molecule.22. The system of claim 21 , wherein the sample fluid comprises at least one biological molecule and one or more chemical reagents for conducting a biological reaction with the at least one biological molecule resulting in the formation of a reaction product upon undergoing the PCR reaction.23. The system of claim 22 , wherein the detector measures at least one property associated with a partition of sample fluid based on detection of emissions from the one or more ...

Methanol production system and methanol production method

A methanol production system of the present disclosure includes: a reformer including a reaction furnace configured to reform methane in a raw material gas to produce a reformed gas containing CO and H2; a reduced-gas generator configured to reduce CO2 to produce a reduced gas containing CO; and a methanol-containing gas generator configured to produce a methanol-containing gas which contains methanol from a reformed gas produced in the reaction furnace and a reduced gas produced in the reduced-gas generator.

GENERATING METHANOL USING ULTRAPURE, HIGH PRESSURE HYDROGEN

In various implementations, methanol is produced using a (CO+H) containing synthesis gas produced from a combined POX plus EHTR or a combined ATR plus EHTR at a pressure of 70 bar to 100 bar at the correct stoichiometric composition for methanol synthesis so that no feed gas compressor is required for the feed to the methanol synthesis reactor loop. 111-. (canceled)12. A system for producing methanol , comprising;an air separation plant that produces oxygen using air compressors driven by a gas turbine;a fired heater that heats a hydrocarbon feed stream using exhaust from the gas turbine;a partial oxidation reactor (PDX) or an autothermal reforming reactor (ATR) that exothermically reacts a first portion of the heated hydrocarbon feed stream with at least one of steam or an oxidant gas comprising molecular oxygen to produce an exothermically generated syngas product;a gas-heated catalytic reformer (GHR) that endothermically reforms a second portion of the hydrocarbon feed stream with steam over a catalyst in a heat exchange reformer to produce an endothermically-reformed syngas product and combines the exothermically generated syngas product and the endothermically-reformed syngas product to produce a combined syngas stream, wherein at least a portion of heat used in generation of the endothermically-reformed syngas product is obtained by recovering heat from the exothermically-generated syngas product and the endothermically reformed syngas product;a waste heat boiler that produces steam in a waste heat boiler by cooling the combined syngas stream;separation unit that separates water from the cooled combined syngas to produce a methanol plant feed at substantially reaction loop pressure;after separating water, a first conduit that passes the cooled combined syngas to a methanol plant; anda second conduit that combines methanol plant combustible effluent with methane fuel to the gas turbine.13. The system of claim 12 , wherein the hydrocarbon feed stream includes ...

Microfluidic Liposome Synthesis, Purification and Active Drug Loading

Microfluidic methods and systems are provided for continuous flow synthesis and active loading of liposomes, which include a liposome formation region configured to form a population of liposomes and a microdialysis region downstream from the liposome formation region and configured to form a transmembrane gradient for active drug loading of the liposomes. Microfluidic methods and systems for high throughput production of liposomes are also provided featuring high aspect ratio microchannels.

SYSTEM FOR SPRAYING PARTICLES ONTO A SUBSTRATE, COMPRISING A REACTOR FOR PRODUCING THE PARTICLES TO BE SPRAYED

A system for spraying particles onto a substrate, including: at least one reactor including at least one inlet for liquid reagents, a reaction zone, and a zone for collection of the particles produced from the liquid reagents in the reaction zone; a dispensing device allowing the particles to be sprayed onto the substrate; and a mechanism guiding the particles from the collection zone towards the dispensing device. 111-. (canceled)12. A system for spraying particles onto a substrate , comprising:at least one reactor comprising at least one inlet for liquid reagents, a reaction zone, and a zone for collection of the particles produced from the liquid reagents in the reaction zone;a dispensing device allowing the particles to be sprayed onto the substrate;means for guiding the particles from the collection zone towards the dispensing device;a collector of the particles;a collector of additive elements;a zone for mixing the particles and the additive elements;a nozzle for spraying a mixture of the particles and the additive elements.13. A system according to claim 12 , wherein the reactor is a microfluidic reactor claim 12 , comprising plates made from silica claim 12 , silicon claim 12 , glass claim 12 , ceramic claim 12 , polymer or plastic having etched channels claim 12 , or comprising capillary tubes communicating with each other.14. A system according to claim 12 , wherein the dispensing device further comprises a mixing member or ultrasound probe arranged in the zone for mixing.15. A system as claimed in claim 12 , wherein a portion downstream from the zone for mixing forms a buffer zone.16. A system as claimed in claim 12 , comprising plural reactors.17. A system as claimed in claim 12 , configured to carry out at least one battery component.18. A system as claimed in claim 12 , as a machine of additive manufacturing configured to carry out via 3D printing of at least two adjacent battery components claim 12 , or a collector and an electrode formed on the ...

Coalescence of droplets

The present invention generally relates to microfiuidics, and, in particular, to systems and methods for coalescing or fusing droplets. In certain aspects, two or more droplets within a microfluidic channel are brought together and caused to coalesce without using electric fields or charges. For example, in certain embodiments, droplets stabilized with a surfactant may be disrupted, e.g., by exposing the droplets to a solvent able to alter the surfactant, which may partially destabilize the droplets and allow them to coalesce. In some instances, the droplets may also be physically disrupted to facilitate coalesce. In addition, in some cases, the positions of one or more droplets may be controlled within a channel using a groove in a wall of the channel. For example, a droplet may at least partially enter the groove such that the position of the droplet is at least partially controlled by the groove.

Microfluidic platelet bioreactor device and systems

The present disclosure relates to the production of platelets from megakaryocytes (Mks). In particular, the present disclosure provides systems and methods for the in vitro production of platelets from Mks using a microfluidic bioreactor having a center flow channel and uniform high-shear micrometer slits. Use of this microfluidic bioreactor enables the continuous production of millions of platelets and facilitates real-time and long-term visualization of proplatelet and platelet generation.

SYSTEM AND METHOD FOR EMULSION BREAKING AND PHASE SEPARATION BY DROPLET ADHESION

Emulsion breaking and phase separation is achieved by droplet adhesion. An emulsion breaking device includes a channel having distinct adjacent zones with distinctly different surface wettability characteristics, namely, solvophilic and solvophobic surfaces. The device is positioned such that the upstream portion of the device is configured to be wetted by the continuous phase of the emulsion, and the downstream portion of the device is configured to be wetted by the dispersed phase of the emulsion. As the emulsion flows from the upstream zone to the downstream zone, the change in surface wettability characteristics promotes adhesion of the dispersed phase as the dispersed phase wets the surface of the downstream portion of the channel, which results in breaking of the emulsion. Subsequent collection of the broken emulsion in a collection vessel results in separation of the disparate phases to facilitate their recapture and recycling. 1. A method of breaking an emulsion comprising:flowing an emulsion of droplets of a dispersed phase entrained in a continuous phase below a critical speed into one end of an emulsion breaking device comprising a body defining an elongated internal channel having an inner surface extending from a single channel inlet to a single channel outlet, a first zone of said channel having an inner surface that is solvophilic to the continuous phase, a second zone of said channel having an inner surface that is solvophobic to the continuous phase, the solvophilic and solvophobic inner surfaces meeting at a boundary intermediate a length of the channel; andcollecting liquid flowing from the emulsion breaking device.2. The method of claim 1 , wherein the collected liquid is collected in a vessel claim 1 , the method further comprising:withdrawing from the vessel one of the dispersed phase and the continuous phase separately from the other of the dispersed phase and the continuous phase.3. The method of claim 1 , wherein said flowing the emulsion ...

POLYMER MONOLITHS FOR SOLVENT EXCHANGE IN CONTINUOUS FLOW MICROFLUIDIC DEVICE

The present disclosure relates to the novel multistep procedure for preparation of polymer monoliths for use in solvent exchange, such as methods to exchange and activate fluoride ions on a flow through microfluidic chip for subsequent chemical synthesis. Methods according to the present disclosure include the application of such microfluidic platforms for rapid F18 radiosynthesis on a flow through microfluidic chip with high efficiency, followed by a subsequent nucleophilic fluorination reaction. Various other methods of exchanging and activating fluoride ions on a flow through microfluidic chip are also disclosed. Methods incorporating features of the present invention can be applicable to any flow through microfluidic device in any field, such as radiosyntheses, chemical syntheses, concentration of ions for environmental analyses and sample preparation such as concentrating minute amounts of analyte to improve the downstream detection. 1. A method of exchanging and activating fluoride ions on a flow through microfluidic chip , comprising the steps of:providing a microfluidic chip with one or more channels on or in the chip;vinylizing the microfluidic chip;forming and covalently anchoring polymer monoliths in the one or more channels;{'sup': '18', 'flowing [F] Fluoride ion water through the monoliths in the one or more channels; and'}{'sup': '18', 'eluting the []F fluoride ion via treatment with cryptands and potassium carbonate or potassium bicarbonate, or tetraalkylammonium bicarbonate.'}2. The method of claim 1 , wherein the microfluidic chip comprises glass.3. The method of claim 1 , wherein the one or more channels are serpentine channels formed in the chip.4. The method of claim 3 , wherein the polymer monoliths are within the one or more channels and the volume of the polymer monoliths is at least 13 μL.5. The method of claim 4 , wherein the serpentine channels have a cross section of about 150 μm×150 μm and a length of about 52000 μm.6. The method of claim ...

Dose Synthesis Card for Use with Automated Biomarker Production System

Microfluidic radiopharmaceutical production system and process for synthesizing per run approximately, but not less than, ten (10) unit doses of radiopharmaceutical biomarker for use in positron emission tomography (PET). A radioisotope from an accelerator or other radioisotope generator is introduced into a reaction vessel, along with organic and aqueous reagents, and the mixture heated to synthesize a solution of a pre-selected radiopharmaceutical. The solution is purified by passing through a combination of solid phase extraction purification components, trap and release components, and a filter. The synthesis process reduces waste and allows for production of biomarker radiopharmaceuticals on site and close to the location where the unit dose will be administered to the patient. On-site, as-needed production of radiopharmaceuticals in small doses reduces the time between synthesis of the radiopharmaceutical and administration of that radiopharmaceutical, minimizing loss of active isotopes through decay and allowing production of lesser amounts of radioisotopes overall. 1. A disposable microfluidic radiopharmaceutical synthesis card system comprising:at least one reaction vessel adapted to receive a radioisotope and at least one reagent, said reaction vessel being configured to receive energy from an energy source , whereby when said radioisotope and said at least one reagent are mixed in said reaction vessel and energy is provided to said reaction vessel from said energy source, a radiopharmaceutical solution is synthesized;at least one purification component to purify said radiopharmaceutical solution;a filter adapted to sterilize said radiopharmaceutical solution;a sterile vessel adapted to receive sterile radiopharmaceutical solution following the passage of said radiopharmaceutical solution through said purification column and said filter, said sterile vessel configured to hold multiple unit doses of radiopharmaceutical; anda port in said vessel used to ...

Catalytic Microchannel Reformer

An apparatus and method for enhancing the yield and purity of hydrogen when reforming hydrocarbons is disclosed in one embodiment of the invention as including receiving a hydrocarbon feedstock fuel (e.g., methane, vaporized methanol, natural gas, vaporized diesel, etc.) and steam at a reaction zone and reacting the hydrocarbon feedstock fuel and steam in the presence of a catalyst to produce hydrogen gas. The hydrogen gas is selectively removed from the reaction zone while the reaction is occurring by selectively diffusing the hydrogen gas through a porous ceramic membrane. The selective removal of hydrogen changes the equilibrium of the reaction and increases the amount of hydrogen that is extracted from the hydrocarbon feedstock fuel. 1. An apparatus comprising:a ceramic microchannel device for reforming a hydrocarbon fuel to produce hydrogen gas, wherein at least part of the ceramic microchannel device is fabricated from a ceramic made be mixing alumina powder with a phosphate-containing reagent to react with the alumina powder.2. The apparatus of claim 1 , wherein the ceramic microchannel device comprises a reaction zone to react the hydrocarbon with steam to produce the hydrogen gas.3. The apparatus of claim 2 , wherein the hydrogen gas is received in a product zone.4. The apparatus of claim 3 , further comprising a porous membrane positioned between the reaction zone and the product zone.5. The apparatus of claim 1 , comprising confined spaces having lateral dimensions of less than 1 mm.6. The apparatus of claim 1 , wherein the ceramic microchannel device comprises a very high surface area and a continuous nanopore network.7. The apparatus of claim 1 , wherein claim 1 , the ceramic microchannel device comprises phosphate-bonded ceramic materials.8. The apparatus of claim 1 , wherein the ceramic microchannel device comprises at least one of micro-sized pores and nano-sized pores.9. The apparatus of claim 8 , wherein the at least one of micro-sized pores and ...

A PULSED FLOW REACTOR AND USE THEREOF

A planar flow reactor includes a straight planar process channel, a flow generator, and a plurality of static mixing elements disposed within the process channel. The flow generator is configured to generate a pulsatile flow within the process channel, and the static mixing elements are configured to locally split and recombine the flow. The straight planar process channel enables the generation of a flow pattern that is largely independent of the width of the process channel, meaning that the throughput may be increased by increasing the width without significantly affecting the residence time distribution or the flow behavior. Furthermore, by creating a pulsatile flow within the process channel, turbulence and/or chaotic fluid flows may be generated even at low net flow rates, i.e. low net Reynolds numbers. 1. A flow reactor comprising:a straight planar process channel having a longitudinal direction and being delimited by a bottom wall, a top wall, two side walls, a first end wall, and a second end wall opposite to said first end wall along said longitudinal direction, the process channel comprising at least one inlet at said first end wall configured to introduce at least one feed stream into said process channel and at least one outlet at said second end wall configured to discharge at least one product stream from said process channel;a flow generator configured to generate a pulsatile flow within said process channel, the pulsatile flow comprising a unidirectional net flow component through said process channel along said longitudinal direction and an oscillatory flow component superposed on said net flow component; anda plurality of static mixing elements disposed within said process channel and configured to locally split and recombine the pulsatile flow.2. The flow reactor according to claim 1 , wherein said flow generator is configured to generate said pulsatile flow with a normalized oscillatory Reynolds number that is at least 5v claim 1 , where v is a ...

SYSTEMS AND METHODS FOR PRODUCING A CHEMICAL PRODUCT

The invention generally provides systems and methods for producing a chemical product. In certain embodiments, the invention provides systems that include a chemical product production unit. The chemical production unit includes a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow. The system also includes a droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product. 1. A system for producing a chemical product , the system comprising:a chemical product production unit comprising a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow; anda droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product.2. The system according to claim 1 , further comprising a controller.3. The system according to claim 2 , wherein the system comprises one or more sensors.4. The system according to claim 3 , wherein the controller is configured to receive data from the sensors that allow the controller to monitor a process occurring in one or more of the microfluidic modules.5. The system according to claim 4 , wherein the controller is configured to adjust one or more parameters within the one or more of the microfluidic modules based on the received data.6. The system according to claim 2 , wherein the chemical product is a pharmaceutical drug and the controller comprises a program that determines an optimal drug ...

PROCESS FOR PRODUCING NANOPARTICLES

Provided is a method for producing a nanoparticle having a uniform particle diameter. A method for producing a nanoparticle comprising an amphiphilic block polymer, the method comprising: with use of a nanoparticle production device that includes: a polymer solution supply channel Cp; an aqueous liquid supply channel Cw, Cw; a junction J of the channels; a nanoparticle formation channel Cn; and a nanoparticle-containing liquid outlet On, supplying a solution of a polymer and an aqueous liquid to the junction J; forming a nanoparticle while bringing a laminar flow of the polymer solution and a laminar flow of the aqueous liquid into contact with each other; obtaining a liquid containing the formed nanoparticle from the nanoparticle-containing liquid outlet; and controlling a particle diameter of the nanoparticle by measuring a statistic of the particle diameter of the formed nanoparticle in real time, and by controlling at least one of an amount of the polymer solution supplied to the junction and an amount of the aqueous liquid supplied to the junction such that the statistic becomes a desired value. 1. A method for producing a nanoparticle comprising an xamphiphilic block polymer , comprising:supplying a polymer solution of an amphiphilic block polymer and an aqueous liquid to a nanoparticle production device comprising a polymer solution supply channel, an aqueous liquid supply channel, a junction joining the polymer solution supply channel and the aqueous liquid supply channel, a nanoparticle formation channel positioned downstream of the junction and a nanoparticle containing liquid outlet positioned on a downstream end of the nanoparticle formation channel;bringing a laminar flow of the polymer solution supplied through the polymer solution supply channel and a laminar flow of the aqueous liquid supplied through the aqueous liquid supply channel into contact with each other from the junction toward the downstream side of the nanoparticle formation channel such ...

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

Automated Radiopharmaceutical Production and Quality Control System

An automated radiopharmaceutical production and quality control system includes a particle accelerator, a radiopharmaceutical micro-synthesis subsystem, and quality control subsystem. The micro-accelerator of the improved biomarker generator is optimized for producing radioisotopes useful in synthesizing radiopharmaceuticals in quantities on the order of multiple unit doses, allowing for significant reductions in size, power requirements, and weight when compared to conventional radiopharmaceutical cyclotrons. The radiopharmaceutical micro-synthesis subsystem encompasses a small volume chemical synthesis system comprising a microreactor and/or a microfluidic chip and optimized for synthesizing the radiopharmaceutical in small quantities, allowing for significant reductions in processing time and in the quantity of radioisotope required. The automated quality control subsystem is used to test the composition and characteristics of the radiopharmaceutical to ensure that it is safe to inject.

METHOD AND DEVICE FOR CARRYING OUT A REACTION BETWEEN AT LEAST TWO REACTANTS

A method for carrying out a reaction between at least two reactants in a liquid reaction solution in at least one reaction zone so as to produce a reaction product includes carrying out a reaction continuously in a reaction flow for the at least one reaction zone in an extension of the at least one reaction zone as far as at least one reaction product outlet, introducing each of the at least two reactants over the extension of the at least one reaction zone via inlets in which the reaction flow is introduced, and removing the reaction product via the at least one reaction product outlet. 1. A method for carrying out a reaction between at least two reactants in a liquid reaction solution in at least one reaction zone so as to produce a reaction product , the method comprising:a) carrying out the reaction continuously in a reaction flow for the at least one reaction zone in an extension of the at least one reaction zone as far as at least one reaction product outlet;b) introducing each of the at least two reactants over the extension of the at least one reaction zone via inlets in which the reaction flow is introduced; andc) removing the reaction product via the at least one reaction product outlet;wherein the at least two reactants are gaseous,wherein the inlets are spanned by sieve elements or membranes, andwherein the reactants are introduced in series and in an alternating manner into the reaction flow at each of the at least two inlets over the extension of the at least one reaction zone until saturation in the reaction solution is reached.2. The method according to claim 1 , wherein one of the at least two reactants is hydrogen and another of at least two reactants is oxygen claim 1 , andwherein the reaction product is hydrogen peroxide.3. The method according to claim 1 , wherein at least one catalyst material is dissolved or suspended in at least one of the reactants.4. A device for carrying out a continuous reaction between at least two reactants in a liquid ...

SYSTEMS AND METHODS FOR HANDLING MICROFLUIDIC DROPLETS

The invention generally relates to assemblies for displacing droplets from a vessel that facilitate the collection and transfer of the droplets while minimizing sample loss. In certain aspects, the assembly includes at least one droplet formation module, in which the module is configured to form droplets surrounded by an immiscible fluid. The assembly also includes at least one chamber including an outlet, in which the chamber is configured to receive droplets and an immiscible fluid, and in which the outlet is configured to receive substantially only droplets. The assembly further includes a channel, configured such that the droplet formation module and the chamber are in fluid communication with each other via the channel. In other aspects, the assembly includes a plurality of hollow members, in which the hollow members are channels and in which the members are configured to interact with a vessel. The plurality of hollow members includes a first member configured to expel a fluid immiscible with droplets in the vessel and a second member configured to substantially only droplets from the vessel. The assembly also includes a main channel, in which the second member is in fluid communication with the main channel. The assembly also includes at least one analysis module connected to the main channel. 1. An assembly , the assembly comprising:at least one droplet formation module, wherein the module is configured to form droplets surrounded by an immiscible fluid;at least one chamber comprising an outlet, wherein the chamber is configured to receive droplets and an immiscible fluid, and wherein the outlet is positioned to receive substantially only droplets; anda channel, configured such that the droplet formation module and the chamber are in fluid communication with each other via the channel.2. The assembly of claim 1 , wherein the droplet formation module comprises at least one first channel adapted to carry an aqueous fluid and at least one channel adapted to ...

Vortical Thin Film Reactor

We describe vortical thin layer film flow along a spiral channel designed to improve mass and heat transfer efficiency for a multitude of physicochemical reactions and processes. Spiral channels, commonly augmented by centrifugal rotation, support rapid reaction between one or more fluids in a given channel. Dean vortices generate screw-shaped patterns processing axially in the channel, repeatedly refreshing radial interfaces. Fluids self-align, self-assemble, stable, controllable, exhibit thin film geometry. Multiple discrete lamellae can flow with independent velocity separated by density and may be soluble or insoluble in one another. Membranes separating spirals allow other interactions. Energy can be provided and extracted from each flow. Flows can enter or exit independently along the channel length. The pressure within each channel is controlled even when operated at the liquid's vapor pressure. The device is scalable to include a multiplicity of flows in a multiplicity of centrifugally rotating chambers.

MICROFLUIDIC METHODS FOR PASSIVE SEPARATION OF CELLS AND PARTICLES

A method of separating a plurality of particles () from a portion of fluid, comprising directing the plurality of particles () into a microchannel (). A first portion () of particles () is focused into an equilibrium position in the microchannel (). The focused first portion () is directed into a first outlet () aligned with the equilibrium position. A portion of the fluid is directed into one or more outlets (). A microfluidic device () for separating a plurality of particles () from a portion of fluid, comprising a microchannel () having a first aspect ratio and a length L, thereby focusing the particles () directed therein into an equilibrium position in the microchannel, wherein at least a first portion () of the particles () focuses at distance X from a beginning of the microchannel (). A first outlet () disposed after distance X and aligned with the equilibrium position to receive at least the first portion () of the particles () after the first portion () focuses into an equilibrium position in the microchannel (). At least a second outlet () for receiving a second portion of the particles () before the second portion focuses into an equilibrium position. 1. A microfluidic device for separating a plurality of particles from a fluid medium , comprising:{'sub': '1', 'a microchannel having a first aspect ratio and a length Lin order to allow the particles directed therein to focus into a first equilibrium position in the microchannel, and'} a first capture portion having a first chamber outlet, the first chamber outlet being separated from the microchannel by a first wall,', 'a second capture portion symmetric with the first capture portion, the second capture portion having a second chamber outlet, the second chamber outlet being separated from the microchannel by a second wall,', 'a main outlet in a third wall opposite the first and second walls, and', 'a main flow area in the chamber between the microchannel and main outlet, the main flow area also defined as ...

An automated, multi-pot high-pressure radio-synthesizer for production of pet tracers

An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the reactor assembly in the vertical direction. A plurality of disposable cassettes are disposed above each of the plurality of reactor assemblies, each cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the cassette. The device includes a three-axis reagent and gas handling robot disposed above the plurality of cassettes and terminates in a vial gripper and a gas manifold having an inert gas port and a vacuum port. The device includes a control system configured to control the horizontal actuator and vertical actuator of each reactor assembly and the three-axis reagent and gas handling robot.

DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid. 115.-. (canceled)16. A method for obtaining a collection of plugs comprising at least one biological molecule and at least one or more chemical reactants for conducting a reaction with the biological molecule , the method comprising the steps of:providing a microfluidic system comprising at least a first and second channel, the first and second channels configured to intersect with each other at a junction, and an outlet adapted for receiving a segment of tubing or a sample tube;continuously flowing an aqueous fluid containing the at least one biological molecule and the at least one or more reagents for conducting the reaction with the biological molecule, through the first channel;continuously flowing a carrier fluid immiscible with the aqueous fluid through the second channel;forming a plurality of the plugs of the aqueous fluid containing the at least one biological molecule and the at least one or more reagents for conducting the reaction with the biological molecule, by partitioning the aqueous fluid with the flowing immiscible carrier fluid at the junction of the first and second channels, the plugs being substantially surrounded by the immiscible carrier fluid flowing through the channel, wherein at least one of the plurality of the plugs comprises the at least one biological molecule and the at least one or more reagents for conducting the reaction with the biological molecule; andcollecting the plurality of the plugs in the segment of tubing or the sample tube, wherein the plugs remain separated by the carrier immiscible fluid.17. The method according to claim 16 , wherein the immiscible carrier fluid is an oil.18. The method according to claim 17 , wherein the oil comprises a surfactant.19. The method according to claim 18 , wherein the surfactant is a ...

MICRO REACTION SYSTEM AND METHOD FOR PREPARING 2-METHYL-4-AMINO-5-CYANOPYRIMIDINE USING SAME

Disclosed herein relates to pharmaceutical engineering, and more particularly to a micro reaction system and a method for preparing 2-methyl-4-amino-5-cyanopyrimidine using the same. An acetamidine hydrochloride solution and an (dimethylaminomethylene)malononitrile solution are separately pumped into the micro reaction system including a micromixer and an agitating microchannel reactor in communication at the same time for a continuous condensation-cyclization reaction to obtain 2-methyl-4-amino-5-cyanopyrimidine. 2. The method of claim 1 , wherein in step (1) claim 1 , the acetamidine hydrochloride solution is prepared by dissolving acetamidine hydrochloride in a methanol solution containing sodium methoxide at −20-15° C.; a molar concentration of sodium methoxide in the methanol solution is 0.5-7 mol/L; and a molar ratio of acetamidine hydrochloride in the acetamidine hydrochloride solution to the sodium methoxide in the acetamidine hydrochloride solution is controlled at 1:0.7-1.3.3. The method of claim 1 , wherein in step (1) claim 1 , the (dimethylaminomethylene)malononitrile solution is prepared by dissolving (dimethylaminomethylene)malononitrile in methanol; and a molar concentration of the (dimethylaminomethylene)malononitrile in the (dimethylaminomethylene)malononitrile solution is 0.8-1.8 mol/L.4. The method of claim 1 , wherein in step (1) claim 1 , the micromixer is a static mixer claim 1 , a T-shaped micromixer claim 1 , a Y-shaped micromixer claim 1 , a coaxial flow micromixer or a flow-focusing micromixer.5. The method of claim 1 , wherein in step (1) claim 1 , flow rates of the acetamidine hydrochloride solution and the (dimethylaminomethylene)malononitrile solution pumped into the micromixer are controlled to adjust a molar ratio of the acetamidine hydrochloride to the (dimethylaminomethylene)malononitrile to 1:0.6-1.2; and a temperature in the micromixer is controlled at −10-100° C.6. The method of claim 1 , wherein the micro reaction system ...

FULL CONTINUOUS FLOW PREPARATION METHOD OF 2-METHYL-4-AMINO-5-AMINOMETHYLPYRIMIDINE

A full continuous flow preparation method of 2-methyl-4-amino-5-aminomethylpyrimidine. A mixed solution of cyanoacetamide, N,N-dimethylformamide and a catalyst is mixed with phosphorus oxychloride in a first micro-mixer, and then the reaction mixture undergoes continuous flow reaction in a microchannel reactor to obtain (dimethylaminomethylene) malononitrile. The reaction mixture is subjected to continuous quenching, extraction and separation, and the organic phase is concentrated, mixed with a methanol solution, and then reacted with an organic base to obtain 2-methyl-4-amino-5-cyanopyrimidine. After the mixed liquid is continuously filtered, the filter cake is dissolved in methanol, mixed with hydrogen in a second micro-mixer, and then transported to a fixed-bed reactor for hydrogenation reaction. The products are concentrated, dried and purified to obtain the desired 2-methyl-4-amino-5-aminomethylpyrimidine. 2. The method of claim 1 , wherein in step (1) claim 1 , the catalyst is a pyridine compound; and a molar ratio of cyanoacetamide to N claim 1 ,N-dimethylformamide to the catalyst to phosphorus oxychloride is 1:(1-10):(0.05-0.8):(1-10).3. The method of claim 1 , wherein in step (1) claim 1 , the microchannel reactor consists of a first part and a second part; a reaction temperature of the first part is −20-80° C. claim 1 , and a reaction temperature of the second part is −20-80° C.; a residence time of the reaction mixture in the first part is 0.2-30 minutes claim 1 , and a residence time of the reaction mixture in the second part is 1-60 minutes; and a back pressure of the microchannel reactor is 0.1-5 MPa.4. The method of claim 1 , wherein in step (2) claim 1 , a mass fraction of the inorganic base in the aqueous solution of the inorganic base is 5-50%; the inorganic base is selected from the group consisting of lithium carbonate claim 1 , sodium carbonate claim 1 , potassium carbonate claim 1 , lithium bicarbonate claim 1 , sodium bicarbonate claim 1 , ...

HYDROGEN PRODUCTION MODULE BY INTEGRATED REACTION/SEPARATION PROCESS, AND HYDROGEN PRODUCTION REACTOR USING SAME

The present invention relates to a hydrogen production module by an integrated reaction/separation process, and a hydrogen production reactor using the same, and more specifically, provides a hydrogen production apparatus which laminates a plurality of layered unit cells, is mounted in a pressure-resistant chamber, and can be operated at a high pressure, wherein the unit cell comprises a first modified catalyst, and a second modified catalyst opposite to a hydrogen separator. The hydrogen production module can produce hydrogen using a hydrocarbon, carbon monoxide and an alcohol as sources. Particularly, all the modified catalysts are formed into a porous metal plate form, thereby maximizing the heat transfer effect necessary for reaction. While a reaction and separation of hydrogen simultaneously occur, separated reactants permeate the first modified catalyst so as to come in contact with the same, and then pass through the gap between the hydrogen separator and the second modified catalyst opposite to each other. Therefore, it is possible to obtain a high efficiency over the equilibrium conversion rate of reaction temperature, and high purity hydrogen can be obtained. 1. A hydrogen production module comprising:an inlet passage configured to inflow a reaction gas;a first reforming passage which is communicated with the inlet passage, and is configured to contact the reaction gas supplied from the inlet passage with a first reforming catalyst so as to reform the reaction gas;a second reforming passage which is connected to the first reforming passage to pass the reformed gas between the second reforming passage and a hydrogen separation membrane;an impermeable gas discharge passage configured to discharge an impermeable gas from which hydrogen is removed while passing through the second reforming passage; anda hydrogen discharge passage which is communicated with a permeation side of the hydrogen separation membrane to discharge a hydrogen gas,wherein both end ...

METHOD FOR PREPARING HIGH-QUALITY EPOXIDIZED FATTY ACID ESTER WITH MICRO-REACTION DEVICE

A method for preparing a high-quality epoxidized fatty acid ester with a micro-reaction device, including: respectively pumping an aqueous hydrogen peroxide solution and a carboxylic acid at the same time into a first micro-mixer; after the reaction in the first micro-reactor, respectively pumping the output material and an unsaturated fatty acid ester into a second micro-mixer; 1. A method for preparing a high-quality epoxidized fatty acid ester with a micro-reaction device , comprising the following steps:(1) respectively pumping an aqueous hydrogen peroxide solution and a carboxylic acid at the same time into a first micro-mixer of the micro-reaction device, completely mixing them and then introducing the mixture into a first micro-reactor of the micro-reaction device to react; and(2) respectively pumping the output material of the first micro-reactor and an unsaturated fatty acid ester at the same time into a second micro-mixer of the micro-reaction device, completely mixing them and then introducing the mixture into a second micro-reactor of the micro-reaction device to react completely, water-rinsing the organic phase part of the resultant reaction liquid and drying to obtain the epoxidized fatty acid ester.2. The method of claim 1 , wherein in step (1) claim 1 , the mass fraction of the solute claim 1 , hydrogen peroxide claim 1 , comprised in the aqueous hydrogen peroxide solution is 50-70%.3. The method of claim 1 , wherein in step (1) claim 1 , the carboxylic acid is formic acid claim 1 , acetic acid claim 1 , propanoic acid or butyric acid.4. The method of claim 1 , wherein in step (1) claim 1 , the molar ratio of hydrogen peroxide to carboxylic acid is 1:1-5.5. The method of claim 1 , wherein in step (1) claim 1 , in the first micro-reactor the reaction temperature is 35-85° C. and the residence time is 1-8 min.6. The method of claim 1 , wherein in step (2) claim 1 , the unsaturated fatty acid ester is an unsaturated fatty acid methyl ester claim 1 , an ...

RECONFIGURABLE CHEMICAL SYNTHESIS SYSTEMS AND METHODS

Aspects of the present disclosure relate to reconfigurable chemical synthesis systems and related components and methods. In some embodiments, the described systems comprise one or more fluidic connector units, wherein each fluidic connector unit comprises a plurality of flexible conduits. In certain cases, a system comprising one or more fluidic connector units is configured to synthesize a first chemical compound by providing a plurality of fluidic connections between a plurality of fluid outlets (e.g., outlets of chemical reagent sources, outlets of pumps) and a plurality of fluid inlets (e.g., inlets of reaction modules, inlets of pumps) through the plurality of flexible conduits. In certain cases, the system is subsequently reconfigured by resetting the system (e.g., disconnecting each fluidic connection) and/or configuring the system to synthesize a second, different chemical compound (e.g., disconnecting one or more fluidic connections and providing one or more additional fluidic connections). According to some embodiments, in order to avoid tangling the flexible conduits during reconfiguration of the system, the fluidic connections are disconnected according to certain inventive methods described herein. In certain embodiments, fluidic connections are disconnected in reverse order relative to the order in which they were formed (e.g., the newest fluidic connection is disconnected first, the oldest fluidic connection is disconnected last). In certain embodiments, certain fluidic connections are targeted for disconnection, and additional fluidic connections are disconnected if they overlap the targeted fluidic connections and were formed more recently than the targeted fluidic connections. The fluidic connection and/or disconnection steps may, in some embodiments, be performed by a robotic manipulator. 1. A fluidic system , comprising:a first plurality of fluid outlets;a first plurality of fluid inlets; anda first fluid connector unit comprising a first ...

METHOD OF PREPARING CORE-SHELL PARTICLES

A method of manufacturing core-shell particles comprises: filling a buffer into a rotor, which is extended in a longitudinal direction, and is accommodated so as to be spaced apart from an inner wall side of a non-rotational hollow cylinder extended in a longitudinal direction and then discharging air to outside; rotating the rotor after terminating the filling; forming a core-shell precursor by supplying raw materials from a first storage and a second storage, which comprise a material forming a core, into an interior of the cylinder in which the rotor rotates; supplying a shell material for coating the core to the interior of the cylinder in which a core-type precursor is formed; separating a liquid comprising core-shell particles formed through the supplying into a solid and a liquid; and drying the core-shell particles obtained through the separating. 1. A method of manufacturing core-shell particles , the method comprising:filling a buffer into a rotor, which is extended in a longitudinal direction, and is accommodated so as to be spaced apart from an inner wall side of an non-rotational hollow cylinder extended in a longitudinal direction and then discharging air to outside;rotating the rotor after terminating the filling;forming a core-shell precursor by supplying raw materials from a first storage and a second storage, which comprise a material forming a core, into an interior of the cylinder in which the rotor rotates;supplying a shell material for coating the core to the interior of the cylinder in which a core-type precursor is formed;separating a liquid comprising core-shell particles formed through the supplying into a solid and a liquid; anddrying the core-shell particles obtained through the separating.2. The method according to claim 1 , wherein as the liquid comprising the core-shell particles separated at the separating claim 1 , a reactant in a normal state within the reactor is used.3. The method according to claim 1 , wherein lithium chloride ...

METHOD OF SYNTHESIS AND TESTING OF COMINATORIAL LIBRARIES USING MICROCAPSULES

Methods for use in the synthesis and identification of molecules which bind to a target component of a biological system or modulate the activity of a target are described. 1. A method of forming a small molecule compound comprising:providing at least a first aqueous fluid comprising at least a first small molecule compound having a molecular weight of less than 500 Daltons;providing at least a second aqueous fluid comprising at least a second small molecule compound having a molecular weight of less than 500 Daltons;encapsulating said at least first small molecule compound into at least a first aqueous microcapsule within an immiscible fluorocarbon oil;encapsulating said at least second small molecule compound into at least a second aqueous microcapsule within an immiscible fluorocarbon oil; andfusing said at least first and said at least second aqueous microcapsules, thereby causing a chemical reaction between said at least first and at least second small molecule compounds to form at least a third small molecule compound.2. The method of claim 1 , wherein said at least first small molecule compound is attached to a microbead.3. The method of claim 1 , wherein said at least second small molecule compound is attached to a microbead.4. The method of claim 1 , further comprising isolating said at least third small molecule compound.5. The method of claim 1 , further comprising identifying said at least third small molecule compound.6. The method of claim 5 , wherein said at least third small molecule compound is identified by its optical properties.7. The method of claim 1 , further comprising identifying said at least first and at least second small molecule compounds which reacted to form said at least third small molecule compound.8. The method of claim 1 , wherein said at least first small molecule compound comprises at least a first label and said at least second small molecule compound comprises at least a second label claim 1 , wherein said at least first and ...

SYSTEMS AND METHODS FOR SYNTHESIZING CHEMICAL PRODUCTS, INCLUDING ACTIVE PHARMACEUTICAL INGREDIENTS

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product. 129-. (canceled)30. A method for producing chemical products , comprising:transporting a first fluid comprising a first chemical reactant through a first module comprising a chemical reactor and at least a second unit operation fluidically connected in parallel, and through a second module connected to the first module in series, the second module comprising at least one separator and at least a fourth unit operation fluidically connected in parallel, such that the first chemical reactant within the first fluid is reacted to form a first chemical product that is transported out of the second module; andsubsequently, transporting a second fluid comprising a second chemical reactant through the first module and the second module such that the second chemical reactant within the second fluid is reacted to form a second chemical product, without forming the first chemical product, such that the second chemical product is transported out of the second module; no additional unit operations are newly fluidically connected to the first and second modules between the steps of transporting the first fluid and transporting the second fluid, and', 'no unit operations are fluidically disconnected from the first and second modules between the steps of transporting the first fluid and transporting the second fluid., 'wherein31. The method of claim 30 , wherein transporting the first fluid through the separator comprises separating the first fluid into a first stream containing the first chemical product and a second stream containing a first chemical byproduct.32. The method of claim 30 , wherein the first and/ ...

Ammonia Decomposition Apparatus and System and Hydrogen Production Method

An ammonia decomposition apparatus comprises a casing, a heating zone, a heat exchange zone, a reaction section and a heat exchange coil. The heat exchange coil is spirally wound on an outer wall of the reaction section to efficiently heat ammonia gas. The reaction section has a first reaction zone and a second reaction zone communicated successively, the ammonia gas decomposed into a nitrogen-hydrogen mixture after entering the first reaction zone, with the second reaction zone decomposing for the second time the residual ammonia gas in the nitrogen-hydrogen mixture produced in the first reaction zone, so that the ammonia gas is decomposed more thoroughly. The conversion rate of ammonia gas can reach 99.9% or more, and the residual amount of ammonia gas in the nitrogen-hydrogen mixture can be less than 1000 ppm. 1. An ammonia decomposition apparatus , comprising:a casing, comprising a heating zone and a heat exchange zone communicated successively;a reaction section, comprising a first reaction zone and a second reaction zone communicated successively, wherein the first reaction zone is disposed in the heating zone and filled with a nickel-based catalyst to form a nickel-based catalyst layer, and the second reaction zone is disposed in the heat exchange zone and filled with a ruthenium-based catalyst to form a ruthenium-based catalyst layer; anda heat exchange coil, spirally wound on outer walls of the second reaction zone and the first reaction zone successively, provided with an ammonia gas inlet which is disposed near a hydrogen-nitrogen mixed gas outlet of the second reaction zone and an ammonia gas outlet which is in communication with an ammonia gas inlet of the first reaction zone, and capable of feeding a preheated ammonia gas into the first reaction zone and the second reaction zone successively for carrying out reaction therein.2. The ammonia decomposition apparatus according to claim 1 , wherein a thickness ratio of the nickel-based catalyst layer to the ...

Micropump and/or micromixer with integrated sensor and process for its manufacture

Vorgeschlagen wird eine Mikromembranpumpe und/oder ein Mikromischer, mit einer Antriebsmembran (10), mindestens einem Einlass und mindestens einem Auslass (3), und einem Pumpen-/Mischerkörper (9), welcher zusammen mit der Antriebsmembran (10) mindestens eine Pump-/Mischerkammer (300) bildet dadurch gekennzeichnet, dass in die Mikropumpe/ den Mikromischer mindestens ein Messfühler (400) integriert ist. Als Messfühler wird bevorzugt eine Elektrodenanordnung gewählt, welche die Anwendung elektrochemischer Messverfahren ermöglicht. Dies kann z. B. eine parallele Platten Anordnung sein. Weiterhin wird die Anwendung von Auswerteverfahren der multivariaten Statistik oder der Mustererkennung vorgeschlagen. A micromembrane pump and / or a micromixer is proposed, with a drive membrane (10), at least one inlet and at least one outlet (3), and a pump / mixer body (9), which together with the drive membrane (10) has at least one pump / Mixing chamber (300) is characterized in that at least one measuring sensor (400) is integrated in the micropump / micromixer. An electrode arrangement which enables the use of electrochemical measuring methods is preferably selected as the measuring sensor. This can e.g. B. be a parallel plate arrangement. Furthermore, the use of evaluation methods of multivariate statistics or pattern recognition is proposed.

Fluidization and Solids Processing In Microchannel Devices

This invention describes gas-solid, liquid-solid and gas-solid-liquid processes in microchannels devices including such processes as heterogeneous catalysis, particle formation, particle attrition, particle separation and adsorption or desorption of selected species. Various processes can be enhanced by the unique properties of microchannels such as the predominance of laminar flow, high rates of shear, high rates of heat transfer and high rates of mass transfer. Also encompassed by this invention are methods for the introduction to and removal from microchannels of particle containing fluid streams.

使用微通道技术进行烷化或酰化反应的方法

在此公开的发明涉及一种方法，其包括：使包含反应物底物的第一反应物进料流(314)和包含烷化剂、酰化剂或其混合物的第二反应物进料流(342)，在工艺微通道(310)内流动，并彼此接触以形成包括至少一种烷化产物、至少一种酰化产物，或其混合物的产物(316)；将热量从工艺微通道传递至散热装置(320)；以及将产物(316)从工艺微通道中移出。

Microfluidic chemical reactor for the manufacture of chemically-produced nanoparticles

The present invention discloses microfluidic modules for making nanocrystalline materials in a continuous flow process. The microfluidic modules include one or more flow path with mixing structures and one or more controlled heat exchangers to process the nanocrystalline materials and reagents in the flow path. The microfluidic modules can be interconnected to form microfluidic reactors that incorporate one or more process functions such as nucleation, growth, and purification.

Microfluid molecular-flow fractionator and bioreactor with integrated active/passive diffusion barrier

A microfluidic device and method is disclosed for fractionating and/or trapping selected molecules with a diffusion barrier or porous membrane. The device includes a source fluid flow channel and a target fluid flow channel. The target fluid flow channel and the source fluid flow channel meet at cross-channel area and are in fluid communication with each other. A porous membrane separates the source fluid flow channel from the target fluid flow channel in the cross-channel area. A field-force/gradient mechanism may be positioned proximate the porous membrane with or without detection/state monitoring devices.

A system and a method for the implementation of chemical, biological or physical reactions

The invention relates to a system for the implementation of chemical, biological or physical reactions, consisting of - one or more magnetic micro-reactors (13), each comprising a shell (3) made of hydrophobic magnetic nanoparticles encapsulating an aqueous core (2), - a plane platform (1) comprising a surface (12) to receive the micro-reactors (13), - a source (14) that generates a magnetic field above or underneath the platform (1) for manipulating the one or more hydrophobic magnetic micro-reactors (13), or for moving them along the surface (12) of the platform (1) from one position to another position, characterized in that the aqueous core (2) of the one or more magnetic micro-reactors (13) contains a reaction solution or buffer, and wherein the magnetic field generated by the source (14) correlates to a defined position on the surface of the platform (1).

Method of continuously separating mixtures of microscopic dielectric particles and apparatus for carrying through this method

A method of separating mixtures of microscopic dielectric particles in sunsions in an apparatus for carrying the method. A mixture of particles is forced onto guide paths by dielectrophoretic forces or by a flow of the suspension medium with an additional force, which is provided to compensate the force causing the particles to move along the guide paths for specific particle species causing the specific particle species to be fed out from the mixture of particles. The apparatus may be integrated on surfaces of silicon wafers at low cost and in mass-production numbers, and is suitable for isolating minute particles such as biological cells, cell organelles, bio molecules as well as organic dielectric particles.

pipette

An Apparatus of Core-Shell Particles and Preparation Methods Using Thereof

The present invention relates to an apparatus for producing core-shell particles and a producing method of the core-shell particles using the same. The apparatus includes: a reactor; a first storage part which is joined and installed on a first raw material inlet of the reactor; a second storage part which is joined and installed on a second raw material inlet of the reactor; a solid and liquid material separation part which is joined and installed on an outlet of the reactor to separate a product, discharged from the outlet, into solid particles and liquid; and a drying part which is joined and installed on the solid and liquid separation part to dry solid particles separated by the solid and liquid separation part. According to the present invention, the present invention provides the apparatus for producing the core-shell particles which forms the core-shell particles by injecting gas, liquid and/or solid materials while a liquid solvent exists.

Mikropumpe und/oder Mikromischer mit integriertem Sensor und Verfahren zu dessen Herstellung

Vorgeschlagen wird eine Mikromembranpumpe und/oder ein Mikromischer, mit einer Antriebsmembran (10), mindestens einem Einlass und mindestens einem Auslass (3), und einem Pumpen-/Mischerkörper (9), welcher zusammen mit der Antriebsmembran (10) mindestens eine Pump-/Mischerkammer (300) bildet dadurch gekennzeichnet, dass in die Mikropumpe/ den Mikromischer mindestens ein Messfühler (400) integriert ist. Als Messfühler wird bevorzugt eine Elektrodenanordnung gewählt, welche die Anwendung elektrochemischer Messverfahren ermöglicht. Dies kann z. B. eine parallele Platten Anordnung sein. Weiterhin wird die Anwendung von Auswerteverfahren der multivariaten Statistik oder der Mustererkennung vorgeschlagen. <IMAGE>

Chemical reactor and method for gas phase reactant catalytic reactions

The present invention is a chemical reactor and method for catalytic chemical reactions having gas phase reactants. The chemical reactor has reactor microchannels for flow of at least one reactant and at least one product, and a catalyst material wherein the at least one reactant contacts the catalyst material and reacts to form the at least one product. The improvement, according to the present invention is: the catalyst material is on a porous material having a porosity that resists bulk flow therethrough and permits molecular diffusion therein. The porous material further has a length, a width and a thickness, the porous material defining at least a portion of one wall of a bulk flow path through which the at least one reactant passes.

Process using microchannel technology for conducting alkylation or acylation reaction

The disclosed invention relates to a process, comprising: flowing a first reactant feed stream comprising a reactant substrate and a second reactant feed stream comprising an alkylating agent, an acylating agent or a mixture thereof, in a process microchannel in contact with each other to form a product comprising at least one alkylation product, at least one acylation product, or a mixture thereof; transferring heat from the process microchannel to a heat sink; and removing the product from the process microchannel.

Support for use in microchannel processing

The application relates to devices and processes using microchannel technology. In particular, the application relates to apparatus comprising at least one microchannel (310), a porous thermally conductive support in the microchannel and in contact with a heat transfer wall (400), a catalyst or a sorption medium supported by the porous support and a heat source and/or heat sink (360). The application also relates to processes for conducting chemical reactions in the microchannel reactor.

Chemical reactor and method for catalytic gas phase reactions.

An Apparatus for Manufacturing Particles and Preparation Methods Using Thereof

The present invention relates to an apparatus for manufacturing particles, which comprises: a hollow body extended in the longitudinal direction; a first material inlet and a second material inlet formed on one end of the body respectively to be connected to the inside of the body; a reactant outlet formed to be connected to the inside of the body; at least one first reactor including a mixing means mixing materials flowing in from the first material inlet and the second material inlet; a hollow cylinder extended in the longitudinal direction; a rotator extended in the longitudinal direction to be separated from the inner wall of the cylinder; a driving unit rotating the rotator; a reactant inlet connected to the reactant outlet of the first reactor; an outlet formed to be connected to the inside of the cylinder; a heat exchange material transferring path; a heat exchange material inlet; a second reactor including a heat exchange material outlet; a first storage unit connected to the first material inlet of the first reactor; and a second storage unit connected to the second material inlet of the first reactor, and to a method for manufacturing particles using the same. According to the present invention, high purity dispersed particles can be uniformly manufactured.

Microchannel polymerization reactor

A microchannel polymerization reactor comprising: (a) a first microchannel adapted to carry a reactant stream; (b) a fluid conduit adapted to carry a fluid in thermal communication with the first microchannel; and (c) a static mixer in fluid communication with the first microchannel adapted to provide a mixing zone operative to change the cross-sectional fluid flow profile at a predetermined point along the first microchannel without changing the primary direction of the reactant stream through the first microchannel. The present invention also includes a method of carrying out a polymerization reaction within a microchannel reactor comprising: (i) directing at least one of monomer, initiator, water, surfactant, coagulant, and solvent into a reactant stream and into contact with reactant flowing within a first microchannel to initiate a polymerization reaction occurring within a first microchannel; and (ii) mixing the reactant of the reactant stream by positioning at least one static mixer in series with the reactant stream, where the static mixer is adapted to change a cross-sectional fluid flow profile of the reactant stream flowing through the first microchannel without changing a primary direction of the reactant stream through the first microchannel.

用于在不混溶流体之间进行扩散传递的方法与设备

在不混溶液体之间扩散传递诸如溶质之类的物质然后在不混合的情况下分离所说的液体的方法与设备：薄板的相反侧上具有第一和第二流路，它们用于传送第一和第二不混溶的流体，其中，薄板上开孔的高度不大于200微米，在各开孔内的流体之间会形成稳定的界面，在紧邻上述界面处有显著量的流体流。在上述界面的两端进行扩散传递，然后流体在不混合的情况下流离上述区域。所述流路按垂直于薄板测量时的宽度在10至500微米之间。各开孔的壁面可以是平行的或者是呈锥形的。

Recirculating reactor

The invention provides a recirculating reactor for converting a substrate to a product. The reactor comprises a reaction chamber and a recirculation system, said recirculation system comprising a separator. The reaction chamber contains a catalyst, and comprises a chamber body, a chamber inlet and a chamber outlet. The recirculation system is adapted for recirculating liquid from the chamber outlet to the chamber inlet, and the separator is used for separating a by-product from the liquid.

Method for gas phase reactant catalytic reactions

The present invention provides chemical reactors and reaction chambers and methods for conducting catalytic chemical reactions having gas phase reactants. In preferred embodiments, these reaction chambers and methods include at least one porous catalyst material that has pore sizes large enough to permit molecular diffusion within the porous catalyst material.

Catalysts having catalytic material applied directly to thermally-grown alumina and catalytic methods using same, improved methods of oxidative dehydrogenation

The invention describes catalysts, methods of making catalysts, methods of making a microchannel reactor, and methods of conducting chemical reactions. It has been discovered that superior performance can be obtained from a catalyst formed by directly depositing a catalytic material onto a (low surface area) thermally-grown alumina layer. Improved methods of conducting oxidative dehydrogenations are also described.

Coordinated uniform coating in microchannel equipment

Universal flow module

METHOD AND APPARATUS FOR DIFFUSIVE TRANSFER BETWEEN IMMISCIBLE FLUIDS.

본 발명은 비혼화성 유체 사이의 용질과 같은 물질의 확산 전달 및 혼합 없이 액체의 후속 분리를 촉진시키기 위하여, 구멍(10)의 높이가 200μm 미만이고(시트의 폭 및 유체 흐름의 방향에 대해 수직으로 측정됨), 각각의 구멍내의 유체 사이의 경계면이 형성되고 경계면에 바로 인접한 위치에 다량의 유체 흐름가 있는, 소공성 시트(8)의 반대면상에 제1 및 제2비혼화성 유체를 운반시키는 제1 및 제2흐름 경로(1,2)를 갖는 장치 및 방법에 관한 것이다. 확산 전달은 경계면을 횡단하여 일어나고, 후속하여 유체는 혼합 없이 영역으로부터 유동한다. 시트(8)에 대해 수직으로 측정된 흐름 경로의 폭은 10 내지 500μm이다. 각각의 구멍의 벽은 평행하거나 점점 가늘어진 형태일 수 있다.

Mixing in wicking structures and the use of enhanced mixing within wicks in microchannel devices

본 발명은 진보된 위킹(wicking) 구조물 및 이 구조물의 사용 방법을 기술한다. 진보된 위킹 구조물을 사용하면 세공(small pore)의 사용을 통해 높은 모세관압을 유지하면서 빠른 질량 전달을 촉진할 수 있다. 마이크로채널(microchannel) 내 위킹층 내에서의 향상된 혼합에 의해 유체 접촉 공정에서 특히 향상된 결과를 달성할 수 있다. The present invention describes an advanced wicking structure and how to use the structure. Advanced wicking structures allow the use of small pores to promote fast mass transfer while maintaining high capillary pressure. Particularly improved results can be achieved in the fluid contact process by improved mixing within the wicking layer in the microchannel.

Gas exchange chip, method of gas extraction using the same, and totally organic matter carbon measuring instrument

本发明涉及一种气体交换芯片，目的在于提高气体交换装置中的气体移动速度，该气体交换芯片的特征在于，具备：基体(1)、(2)；形成在基体(1)、(2)内，分别具有入口和出口的两个流路(3)、(4)；连通这两个流路(3)、(4)的多个槽(9)。为了液体不能通过而使气体成分能够移动，槽(9)的内表面的至少一部分被施以疏水性处理，且其截面面积的大小被设定。向一方的流路(3)中通入含有二氧化碳的样品水，向另一方的流路(4)中通入纯水，使样品水中的二氧化碳移动到纯水中。

Method and apparatus for diffusive transfer between immiscible fluids

본 발명은 비혼화성 유체 사이의 용질과 같은 물질의 확산 전달 및 혼합 없이 액체의 후속 분리를 촉진시키기 위하여, 구멍(10)의 높이가 200㎛ 미만이고(시트의 폭 및 유체 흐름의 방향에 대해 수직으로 측정됨), 각각의 구멍내의 유체 사이에 경계면이 형성되고 경계면에 바로 인접한 위치에 다량의 유체 흐름가 있는, 소공성 시트(8)의 반대면상에 제 1 및 제 2 비혼화성 유체를 운반시키는 제 1 및 제 2 흐름 경로(1,2)를 갖는 장치 및 방법에 관한 것이다. 확산 전달은 경계면을 횡단하여 일어나고, 후속하여 유체는 혼합 없이 영역으로부터 유동한다. 시트(8)에 대해 수직으로 측정된 흐름 경로의 폭은 10 내지 500㎛이다. 각각의 구멍의 벽은 평행하거나 점점 가늘어진 형태일 수 있다. In order to facilitate subsequent separation of the liquid without diffusion transfer and mixing of materials such as solutes between the immiscible fluids, the present invention provides that the height of the holes 10 is less than 200 μm (perpendicular to the width of the sheet and the direction of fluid flow). Agent for conveying the first and second immiscible fluids on opposite sides of the porosity sheet 8, with an interface formed between the fluid in each hole and a large amount of fluid flow at a location immediately adjacent to the interface. A device and method having a first and second flow paths (1, 2). Diffusion transfer occurs across the interface and subsequently fluid flows out of the region without mixing. The width of the flow path measured perpendicular to the sheet 8 is 10 to 500 μm. The walls of each hole can be parallel or tapered.

Microfabricated differential extraction device and method

This invention provides a microfabricated extraction system and methods for extracting desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under conditions in which inertial effects are negligible. The contact between the two streams is maintained for a sufficient period of time to allow differential transport of the desired particles from the sample stream into the extraction stream. In a preferred embodiment the differential transport mechanism is diffusion. The extraction system of this invention coupled to a microfabricated diffusion-based mixing device and/or sensing means allows picoliter quantities of fluid to be processed or analyzed on devices no larger than silicon wafers.

Micro column reactor

Mikrosäulenreaktor zur Durchführung von Reaktionen an festen Phasen und/oder mit biologischen Zellen bestehend aus mindestens einem ersten und einem zweiten Substratplättchen (1; 2), die miteinander flächig verbunden sind, wobei in wenigstens eins der Substratplättchen (1; 2) wenigstens ein längserstreckter Kanal (3) eingebracht ist, der in einem vorgebbaren Abschnitt (a) seiner Länge von zwei durch das Substratplättchen geführten Durchtrittsöffnungen (41; 42) für den Zulauf von Substrat bzw. Ablauf von Produkt erfasst ist, wobei die Durchtrittsöffnungen (41; 42) vom Kanal (3) durch eine teildurchlässige siebartige Membran (5; 50) getrennt sind, deren Durchlassbereiche (51) so bemessen sind, dass sie in den Kanal (3) eingebrachte Mikroperlen und/oder Zellen (7) vorgebbar am Eintritt in die Durchtrittsöffnungen (41; 42) hindern, und dass der Kanal (3), außerhalb des durch die Durchtrittsöffnungen (41; 42) erfassten Abschnitts (a), mit wenigstens zwei weiteren Öffnungen (61; 62) versehen ist und Mittel (92) zum zeitweisen Verschluss wenigstens einer der Durchtrittsöffnungen...

Microfluidic chip for synthesizing radioactively labeled molecules suitable for human imaging with positron emission tomography

The invention concerns automated, inegrated microfluidic devices comprising a chemical reaction chip for performing reactions, such as the preparation of radiopharmaceutical compounds. The chip comprises an integrated microscale column and is configured for liquid flow from the column to at least one flow channel. The fluid flow is controlled by at least two on-chip valves. These double valves are configured consecutively and within proximity of 300 micrometer from each other. The reaction chamber is substantially "coinshaped", e.g. a reaction cylinder, preferably having a height diameter to height ratio greater than 3. Curved inlet and outlet channels ensure en effective elution.

Systems for handling microfludic droplets

The invention generally relates to assemblies for displacing droplets from a vessel that facilitate the collection and transfer of the droplets while minimizing sample loss. In certain aspects, the assembly includes at least one droplet formation module, in which the module is configured to form droplets surrounded by an immiscible fluid. The assembly also includes at least one chamber including an outlet, in which the chamber is configured to receive droplets and an immiscible fluid, and in which the outlet is configured to receive substantially only droplets. The assembly further includes a channel, configured such that the droplet formation module and the chamber are in fluid communication with each other via the channel. In other aspects, the assembly includes a plurality of hollow members, in which the hollow members are channels and in which the members are configured to interact with a vessel. The plurality of hollow members includes a first member configured to expel a fluid immiscible with droplets in the vessel and a second member configured to substantially only droplets from the vessel. The assembly also includes a main channel, in which the second member is in fluid communication with the main channel. The assembly also includes at least one analysis module connected to the main channel.

Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography

The present application relates to microfluidic devices and related technologies, and to chemical processes using such devices. More specifically, the application discloses a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner. In particular, this application describe an automated, stand-alone, microfluidic instrument for the multi-step chemical synthesis of radiopharmaceuticals, such as probes for PET and a method of using such instruments.

Microfluidic radiosynthesis system for positron emission tomography biomarkers

Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.

Multi-purpose flow module

FIELD: process engineering. SUBSTANCE: proposed invention relates to multi-purpose flow module to be used for extraction, separation reaction and mixing in producing chemicals, medicinal preparations and chemical products of fine organic synthesis. Flow module comprises flow plates and/or heat exchanger plates jointed together. Flow plates has flow channel and one or several connecting holes. One or several barrier plates may be attached to each flow or heat exchanger plate. EFFECT: higher efficiency, improved heat transfer, temperature control. 26 cl, 25 dwg, 5 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 418 630 (13) C2 (51) МПК B01J 19/24 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2008120591/05, 18.10.2006 (24) Дата начала отсчета срока действия патента: 18.10.2006 (73) Патентообладатель(и): АЛЬФА ЛАВАЛЬ КОРПОРЕЙТ АБ (SE) 2 4 1 8 6 3 0 (43) Дата публикации заявки: 10.12.2009 Бюл. № 34 (45) Опубликовано: 20.05.2011 Бюл. № 14 2 4 1 8 6 3 0 R U (85) Дата начала рассмотрения заявки PCT на национальной фазе: 26.05.2008 C 2 C 2 (56) Список документов, цитированных в отчете о поиске: WO 0242704 A1, 30.05.2002. EP 0754492 A2, 22.01.1997. WO 9855812 A1, 10.12.1998. WO 03082460 A1, 09.10.2003. WO 9941915 A1, 19.08.1999. (86) Заявка PCT: SE 2006/001186 (18.10.2006) (87) Публикация заявки РСТ: WO 2007/050013 (03.05.2007) Адрес для переписки: 129090, Москва, ул.Б.Спасская, 25, стр.3, ООО "Юридическая фирма Городисский и Партнеры", пат.пов. А.В.Мицу, рег.№ 364 (54) МНОГОЦЕЛЕВОЙ ПРОТОЧНЫЙ МОДУЛЬ (57) Реферат: Изобретение относится к многоцелевому проточному модулю и может использоваться для осуществления экстракции, реакции, разделения, перемешивания при изготовлении химикатов, лекарственных препаратов, химических продуктов тонкого органического синтеза. Проточный модуль содержит потоковые пластины, и/или пластины теплообменника, сложенные друг с другом. Потоковая пластина имеет канал ...

Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography

본 발명은 자동화된 통합 마이크로유체 장치로서 화학 반응을 위한 화학 반응 칩, 및 칩이 통합되고, 컬럼으로부터 최소한 하나의 유동 채널에 액체 유동을 위하여 구성된 미소규모의 컬럼을 포함하며, 여기서 컬럼으로의 유체 유동은 온-칩 밸브에 의하여 조절되며, 및 마이크로유체 장치 내의 유체 유동을 조절하기 위한 최소한 2개의 온-칩 밸브를 포함한다. 마이크로유체 칩, 양전자 방출 단층촬영, 인체 영상화, 방사성 표지 분자

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients

활성 제약 성분을 포함한 화학적 생성물의 합성을 위한 시스템 및 방법이 제공된다. 본원에 기재된 특정 시스템 및 방법은, 어느 한 화학적 생성물의 제조로부터 또 다른 화학적 생성물의 제조로 스위칭할 때 유닛 작동들을 유체 연결 또는 차단할 필요 없이 여러 화학적 생성물을 제조할 수 있다.

MICROMECHANICAL DEVICES AND METHOD FOR THE STORAGE AND SELECTIVE EXPOSURE OF CHEMICALS

Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography

본 발명은 자동화된 통합 마이크로유체 장치로서 화학 반응을 위한 화학 반응 칩, 및 칩이 통합되고, 컬럼으로부터 최소한 하나의 유동 채널에 액체 유동을 위하여 구성된 미소규모의 컬럼을 포함하며, 여기서 컬럼으로의 유체 유동은 온-칩 밸브에 의하여 조절되며, 및 마이크로유체 장치 내의 유체 유동을 조절하기 위한 최소한 2개의 온-칩 밸브를 포함한다. The present invention is an automated integrated microfluidic device comprising a chemical reaction chip for a chemical reaction, and a microscale column in which the chip is integrated and configured for liquid flow from the column to at least one flow channel, wherein the fluid to the column The flow is controlled by an on-chip valve and includes at least two on-chip valves for regulating fluid flow in the microfluidic device. 마이크로유체 칩, 양전자 방출 단층촬영, 인체 영상화, 방사성 표지 분자 Microfluidic Chips, Positron Emission Tomography, Human Imaging, Radiolabelled Molecules

System for mixing fluids by coalescence of multiple emulsions

System, including methods, apparatus, compositions, and kits, for the mixing of small volumes of fluid by coalescence of multiple emulsions.

System for mixing fluids by coalescence of multiple emulsions

System, including methods, apparatus, compositions, and kits, for the mixing of small volumes of fluid by coalescence of multiple emulsions.

Modular microfluidic system and method for building a modular microfludic system

A “plug-n-play” modular microfluidic system is described herein which can be made by connecting multiple microfluidic components together to form a larger integrated system. For example, the modular microfluidic system includes a motherboard with interconnecting channels and integrated electrodes (or holes for electrodes to pass) which provide electronic connections to external data acquisition and system control devices. The modular microfluidic system can also include channel inserts (which are placed in the channels of the motherboard), heater units, actuator units, fitting components and microchips/modules with different functionalities which are placed on the motherboard.

Fluidic interconnect, interconnect manifold and microfluidic devices for internal delivery of gases and application of vacuum

Interconnect configurations and an interconnect manifold for microfluidic devices (6) is provided. Devices for introducing one or more gases or removing gases from microfluidic cavity elements (8) is also provided. The invention is also directed to methods for making interconnects and to methods for delivery or removal of gasses from microfluidic devices (6).

Protected surfaces of alloys in micro channel devices, catalysts, aluminium oxide-based catalysts, intermediate catalysts and method of producing catalysts and micro channel devices

FIELD: process engineering. SUBSTANCE: invention relates to micro channel reactors and catalysts that comprises a layer of metal aluminide. Micro channel reactor consists of complex micro channel constricted by one micro channel wall and aluminide coat applied on the surface of one micro channel wall. Note here that complex micro channel represents an inner micro channel deferring in one or several following characteristics: one continuous micro channel with turn section, turn angle of 45°, length of 20 cm or more, height and width of 2 mm or less; one micro channel is divided into two sub channels arranged in parallel; complex micro channel makes on of adjacent micro channels with the length of common adjacent section of 1 cm whereon several connecting holes are made on common micro channel wall. Note here that total area of said holes does not exceed 20% of that of micro channel wall whereon said holes are located, while area of each hole does not exceed 1.0 mm 2 . Complex micro channel represents one of five parallel 1 cm-long micro channels. Open ends of said channels communicated with common collector. One size of said collector is thrice the minimum length and width of parallel micro channels. Aluminide layer provides for chemical stability. Besides aluminide increases in metal diffusion from reactor walls to make solid and homogeneous coat for all inner surfaces even in complex-shape channels. EFFECT: accurate control over chemical processes in complex micro channels, stable operation. 17 cl, 14 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 403 967 (13) C2 (51) МПК B01J C23C C23C B01J B01J 19/02 (2006.01) 16/04 (2006.01) 10/50 (2006.01) 35/04 (2006.01) 37/02 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21), (22) Заявка: 2006133516/05, 23.03.2005 (24) Дата начала отсчета срока действия патента: 23.03.2005 (43) Дата публикации заявки: 27.04.2008 2 4 0 3 9 6 7 R U (85) Дата перевода ...

Method of making a product with a micro or nano sized structure and product

Using phase separation technique perforated as well as non-perforated polymeric structures can be made with high aspect ratios (>5). By varying the phase separation process the properties (e.g. porous, non-porous, dense, open skin) of the moulded product can be tuned. Applications are described in the field of micro fluidics (e.g. micro arrays, electrophoretic boards), optics, polymeric solar cells, ball grid arrays, and tissue engineering.

Membrane module for testing agents in contact with cells

(57)【要約】 蓋（３）、底面（４）および側壁（５）によって制限されている内部空間（２）、この内部空間（２）内に配置された第１の毛管メンブラン（６）の系および第２の毛管メンブラン（１１）の系および場合によっては毛管メンブランの他の系を備え、この場合内部空間（２）内の毛管メンブランは、底面（４）と平行な平らな少なくとも１つの層に対して配置されており、内部空間（２）内で毛管外空間で毛管メンブランの周囲には細胞培養空間が形成されており、この場合毛管メンブランは、その両端部の少なくとも片側が内部空間（２）の側壁（５）内に侵入し、内部空間（２）が液密で外向きに密閉されているように、この端部がそれぞれ系に応じて別々に注型材料（９、１０）中に埋設されており、この場合内径を有する全ての系の毛管メンブランは、入口装置（７、１２）および／または出口装置（８、１３）と液体結合されており、この場合内部空間（２）は、０．１〜５ｃｍ ３ の体積を有する、細胞に接する作用物質を試験するためのメンブランモジュール。

Fluidization and solids processing in microchannel devices

This invention describes gas-solid, liquid-solid and gas-solid-liquid processes in microchannels devices including such processes as heterogeneous catalysis, particle formation, particle attrition, particle separation and adsorption or desorption of selected species. Various processes can be enhanced by the unique properties of microchannels such as the predominance of laminar flow, high rates of shear, high rates of heat transfer and high rates of mass transfer. Also encompassed by this invention are methods for the introduction to and removal from microchannels of particle containing fluid streams.

Dehydrogenation of liquid fuel in microchannel catalytic reactor

The present invention is an improved process for the storage and delivery of hydrogen by the reversible hydrogenation/dehydrogenation of an organic compound wherein the organic compound is initially in its hydrogenated state. The improvement in the route to generating hydrogen is in the dehydrogenation step and recovery of the dehydrogenated organic compound resides in the following steps: introducing a hydrogenated organic compound to a microchannel reactor incorporating a dehydrogenation catalyst; effecting dehydrogenation of said hydrogenated organic compound under conditions whereby said hydrogenated organic compound is present as a liquid phase; generating a reaction product comprised of a liquid phase dehydrogenated organic compound and gaseous hydrogen; separating the liquid phase dehydrogenated organic compound from gaseous hydrogen; and, recovering the hydrogen and liquid phase dehydrogenated organic compound.

Fluidization and solids processing in microchannel devices

This invention describes gas-solid, liquid-solid and gas-solid-liquid processes in microchannels devices including such processes as heterogeneous catalysis, particle formation, particle attrition, particle separation and adsorption or desorption of selected species. Various processes can be enhanced by the unique properties of microchannels such as the predominance of laminar flow, high rates of shear, high rates of heat transfer and high rates of mass transfer. Also encompassed by this invention are methods for the introduction to and removal from microchannels of particle containing fluid streams.

Fluidization and solids processing in microchannel devices

This invention describes gas-solid, liquid-solid and gas-solid-liquid processes in microchannels devices including such processes as heterogeneous catalysis, particle formation, particle attrition, particle separation and adsorption or desorption of selected species. Various processes can be enhanced by the unique properties of microchannels such as the predominance of laminar flow, high rates of shear, high rates of heat transfer and high rates of mass transfer. Also encompassed by this invention are methods for the introduction to and removal from microchannels of particle containing fluid streams.

Chemical reactor and method for gas phase reactant catalysis

Process using microchannel technology for conducting alkylation or acylation reaction

The disclosed invention relates to a process, comprising: flowing a first reactant feed stream (314) comprising a reactant substrate and a second reactant feed stream (342) comprising an alkylating agent, an acylating agent or a mixture thereof, in a process microchannel (310) in contact with each other to form a product (316) comprising at least one alkylation product, at least one acylation product, or a mixture thereof; transferring heat from the process microchannel to a heat sink (320); and removing the product (316) from the process microchannel.

Microchannel apparatus and methods of conducting unit operations with disrupted flow

The invention described herein concerns microchannel apparatus that contains, within the same device, at least one manifold and multiple connecting microchannels that connect with the manifold. For superior heat or mass flux in the device, the volume of the connecting microchannels should exceed the volume of manifold or manifolds. Methods of conducting unit operations in microchannel devices having simultaneous disrupted and non-disrupted flow through microchannels is also described.

Method for continuous separation of a mixture of fine dielectric particles and apparatus for carrying out the method

Protected alloy surface in microchannel apparatus and catalyst, alumina-supported catalyst, catalyst intermediate, and catalyst and microchannel apparatus forming method

Microreactor process for making biodiesel

Through-plate microchannel transfer devices

The present disclosure concerns embodiments of a microfluidic transfer device. The device mitigates risk of cross contamination between working fluids and is amenable to high-volume, low-cost manufacturing techniques. The device may be configured for mass transfer, heat transfer, or both. For instance, certain disclosed embodiments incorporate semi-permeable membranes to transfer target substances from one fluid to another. Moreover, the device may incorporate both heat and mass transfer components.

Fluid interconnects, interconnect manifolds and microfluidic devices for internal delivery of gas and application of reduced pressure

(57)【要約】 微小流体性デバイス（６）のための相互接続構成および相互接続マニホルドが、提供される。微小流体性キャビティ要素（８）から、１種以上の気体を導入するためのデバイス、または気体を除去するためのデバイスもまた、提供される。本発明はまた、相互接続を作製するための方法および微小流体性デバイス（６）からの気体の送達または除去のための方法に関する。さらに具体的には、本発明は、中規模の環境または大規模の環境と微小規模の環境との間の流体相互接続に関する。

Microreactor Process for Making Biodiesel

Embodiments of a method for using a microreactor to produce biodiesel. For example, the method may comprise flowing a first fluid comprising an alcohol and a second fluid comprising an oil to the microreactor. Alcohols typically, but not necessarily, are lower aliphatic alcohols, including methanol, ethanol, amyl alcohol or combinations thereof. Biodiesel production can be under supercritical conditions, where such conditions typically are determined relative to the alcohol component. Suitable sources of oil products include soy, inedible tallow and grease, corn, edible tallow and lard, cotton, rapeseed, sunflower, canola, peanut, safflower, and combinations thereof. Catalysts can be used to facilitate biodiesel production, such as metal oxides, metal hydroxides, metal carbonates, alcoholic metal carbonates, alkoxides, mineral acids and enzymes. Oil conversion to biodiesel typically increases with increasing mean microreactor residence time. Certain embodiments of the present invention can include blending biodiesel produced by the method with petroleum-based products.

Integrated chemical synthesizers

A modular reactor system and method for synthesizing chemical compounds characterized by a uniform temperature throughout the reaction mixture by use of a continuous flow reactor under high pressure. The apparatus includes a number of generic components such as pumps, flow channels, manifolds, flow restrictors, and valves. Modular reactors, separator and analyzers on an assembly board provide a system where a modular reactor unit has an I.D. of up 100 μm to optimize control of residence time within a reaction zone.

Microcomponent chemical process sheet architecture

The invention is a microcomponent sheet architecture wherein macroscale unit processes are performed by microscale components. The sheet architecture may be a single laminate with a plurality of separate microcomponent sections or the sheet architecture may be a plurality of laminates with one or more microcomponent sections on each laminate. Each microcomponent or plurality of like microcomponents perform at least one chemical process unit operation. A first laminate having a plurality of like first microcomponents is combined with at least a second laminate having a plurality of like second microcomponents thereby combining at least two unit operations to achieve a system operation.

Microchannel laminated mass exchanger and method of making

The present invention is a microchannel mass exchanger having a first plurality of inner thin sheets and a second plurality of outer thin sheets. The inner thin sheets each have a solid margin around a circumference, the solid margin defining a slot through the inner thin sheet thickness. The outer thin sheets each have at least two header holes on opposite ends and when sandwiching an inner thin sheet. The outer thin sheets further have a mass exchange medium. The assembly forms a closed flow channel assembly wherein fluid enters through one of the header holes into the slot and exits through another of the header holes after contacting the mass exchange medium.

Active microchannel fluid processing unit and method of making

The present invention is an active microchannel fluid processing unit and method of making, both relying on having (a) at least one inner thin sheet; (b) at least one outer thin sheet; (c) defining at least one first sub-assembly for performing at least one first unit operation by stacking a first of the at least one inner thin sheet in alternating contact with a first of the at least one outer thin sheet into a first stack and placing an end block on the at least one inner thin sheet, the at least one first sub-assembly having at least a first inlet and a first outlet; and (d) defining at least one second sub-assembly for performing at least one second unit operation either as a second flow path within the first stack or by stacking a second of the at least one inner thin sheet in alternating contact with second of the at least one outer thin sheet as a second stack, the at least one second sub-assembly having at least a second inlet and a second outlet.

Multiphasic microchannel reactions

Multiphasic reactions, especially those reactions using a phase transfer catalyst, are conducted in microchannel apparatus. Advantageously, these reactions can be conducted with two, planar microlayers of reactants in adjacent laminar flow streams. Microchannel apparatus and methods for conducting unit operations such as reactions and separations in microchannel apparatus is also described. Microchannel apparatus can provide advantages for controlling reactions and separating products, solvents or reactants in multiphase reactions.