ПОДЛОЖКА ДЛЯ ХРАНЕНИЯ ОБРАЗЦА БИОЛОГИЧЕСКОГО МАТЕРИАЛА И СПОСОБ ЕЁ ИЗГОТОВЛЕНИЯ

Изобретение относится к подложке для хранения образцов биологического материала. Описана подложка (1) для хранения образцов биологического материала, где указанная подложка (1) содержит по меньшей мере: первую часть (3) абсорбирующей матрицы (2), предназначенную для хранения образца биологического материала; и вторую часть (4), отличную от первой части (3) и предназначенную для образования очищающей зоны для головки устройства, предназначенного для сбора образца биологического материала с первой части (3), в частности, пуансона, где абсорбирующая матрица изготовлена из материала, основой которого является целлюлоза, и/или бумаги, и/или абсорбирующей пластмассы. Также описаны способ получения подложки, применение подложки, и способ применения подложки. Технический результат: предложена подложка для сбора одного или более образцов биологического материала. 5 н. и 16 з.п. ф-лы, 15 ил.

УСТРОЙСТВО "ОРГАН НА ИНТЕГРАЛЬНОЙ СХЕМЕ"

... 1. Автономное устройство «орган на интегральной схеме» (1), содержащее: ! (a) по меньшей мере, один резервуар для подачи среды (2); и ! (b) по меньшей мере, одну секцию роста органов (3), содержащую, по меньшей мере, одну полость для органов (4, 4а, 4b); и ! где резервуар для подачи среды (2) соединяется, по меньшей мере, с одной секцией роста органов (3) посредством микрожидкостного канала подачи (6) и, по меньшей мере, с одной полостью для органов (4, 4а, 4b). ! 2. Автономное устройство «орган на интегральной схеме» (1) по п.1, где секция роста органов (3) содержит полость для стволовых клеток (9). !3. Автономное устройство «орган на интегральной схеме» (1) по п.1, дополнительно содержащее, по меньшей мере, один резервуар для сброса среды (5), где, по меньшей мере, одна полость для органов (4, 4а, 4b) соединяется, по меньшей мере, с одним резервуаром для сброса среды (5) посредством микрожидкостного канала сброса (7). ! 4. Автономное устройство «орган на интегральной схеме» (1) по п.1 ...

ПОДЛОЖКА ДЛЯ ХРАНЕНИЯ ОБРАЗЦА БИОЛОГИЧЕСКОГО МАТЕРИАЛА И СПОСОБ ЕЁ ИЗГОТОВЛЕНИЯ

ОПТИЧЕСКИЙ ИНДИКАТОР ДЛЯ ОБНАРУЖЕНИЯ БАКТЕРИАЛЬНЫХ ПАТОГЕНОВ

... 1. Устройство обнаружения, содержащее подложку, которую можно сложить, чтобы получить, по меньшей мере, первый и второй находящиеся друг напротив друга листы, при этом вышеуказанные первый и второй листы каждый имеют внутреннюю и наружную поверхность, при этом вышеуказанный первый лист имеет зону контакта образца, оснащенную впитывающей подушечкой, расположенной на вышеуказанной внутренней поверхности первого листа, и вышеуказанный второй лист имеет зону окрашивающего индикатора, расположенную на вышеуказанной внутренней поверхности второго листа напротив вышеуказанной зоны контакта образца, а также окно для результатов на вышеуказанной наружной поверхности второго листа, где проявляется визуальная информация. ! 2. Устройство обнаружения по п.1, отличающееся тем, что вышеуказанная подложка является полужесткой и сгибаемой. ! 3. Устройство обнаружения по п.1, отличающееся тем, что вышеуказанная подложка дополнительно включает третий лист, который сгибается над вышеуказанным вторым листом ...

УСТРОЙСТВО ДЛЯ УХОДА ЗА ПОЛОСТЬЮ РТА

... 1. Устройство для ухода за полостью рта, содержащее:головку;ручку; ипо меньшей мере одну конусовидную щетинку, отходящую от передней поверхности головки, при этом конусовидная щетинка имеет продольную ось и профиль поперечного сечения, имеющий большую ось и малую ось, причем большая ось длиннее малой оси,при этом профиль поперечного сечения конусовидной щетинки представляет собой ромб,при этом устройство для ухода за полостью рта содержит множество конусовидных щетинок, расположенных в пучке щетинок, который отходит от передней поверхности головки,множество конусовидных щетинок в пучке щетинок содержит первую щетинку из конусовидных щетинок и вторую щетинку из конусовидных щетинок, при этом большая ось первой щетинки из конусовидных щетинок не параллельна большой оси второй щетинки из конусовидных щетинок.2. Устройство для ухода за полостью рта по п. 1, в котором отношение большой оси к малой оси больше или равно 1,2:1.3. Устройство для ухода за полостью рта по п. 1, в котором отношение ...

Küvette, Einsatz, Adapter zur optischen Untersuchung kleiner Flüssigkeitsmengen

Küvette umfassend mindestens einen Einsatz mit zwei Messflächen und einem Adapter zum Einsetzen in einem Küvettenschacht einer optischen Messvorrichtung und Mittel von Einsatz und Adapter zum lösbaren Halten des mindestens einen Einsatzes am Adapter mit den Messflächen in einem Abstand voneinander zum Positionieren einer Probe zwischen den Messflächen in einem den Küvettenschacht durchquerenden Strahlengang der optischen Messvorrichtung.

Thermocycler for amplifying nucleic acid stretches in probe, comprises temperature controlling block that is sub-divided into segments each receiving specimens and are thermally separated and are controlled separately

A thermocycler comprises a temperature controlling block that is sub-divided into segments (1-3) each receiving specimens and that are thermally separated and are controlled separately. A thermocycler comprises a temperature controlling block that is fitted to receive specimens and that is driven by a control unit in consecutive cycles to assume in a consecutive matter at different temperature levels, e.g. 40, 70 or 95 [deg]C of a polymerase chain reaction procedure. The temperature controlling block is sub-divided into segments each receiving specimens and that are thermally separated and are controlled separately. A control unit (6) is designed to control the segments at different numbers of cycles, e.g. 4, 7 or 9.

Inkubationsrinne

VORRICHTUNG ZU REIHENUNTERSUCHUNGEN

Steuergerät für relative Feuchtigkeit

Ein Steuergerät (100) für relative Feuchtigkeit zum Steuern der relativen Feuchtigkeit in einem Gasraum, umfassend – eine Vernebler-Quelle, die einen Auslass (12) für vernebelte Flüssigkeit hat, – einen Rahmen (30), bevorzugt einen eine geschlossene Schleife bildenden Rahmen, der einen offenen Bereich umgibt und eine Öffnungsanordnung (33) zum offenen Bereich und in Durchfluss-Wirkverbindung mit dem Auslass umfasst, – eine Strömungs-Antriebs-Anordnung (50), die einen Gasfluss von dem Auslass zu der und aus der Öffnungsanordnung hinaus erzeugt. Weiter im Rahmen der Erfindung liegen ein Liquid-Handling-Roboter umfassend das Gerät, ein Betriebsverfahren des Geräts, ein Immunoassay-Verfahren und Verfahren zur Steuerung des Zeitverlaufs der relativen Feuchtigkeit in einem gashaltigen Raum und zur Herstellung eines vorgegebenen Volumens einer Flüssigkeit.

Verfahren zum Herstellen einer Bilipidschicht sowie Mikrostruktur und Messanordnung

Die vorliegende Erfindung bezieht sich auf ein Verfahren zum Herstellen einer Bilipidschicht über einer einseitig offenen Mikrokavität sowie auf eine Mikrostruktur zum Untersuchen von Lipiddoppelschichten und eine diesbezügliche Messanordnung. Das Verfahren zum Herstellen einer Bilipidschicht über einer einseitig offenen Mikrokavität umfasst die folgenden Schritte: Befüllen der Mikrokavität mit einer Elektrolytlösung; Bewegen eines gelöste Lipide enthaltenden Fluids in einer ersten Richtung auf die Mikrokavität zu; Bewegen des Fluids in einer zweiten Richtung von der Mikrokavität weg; Überwachen des Ausbildens der Bilipidschicht über der Mikrokavität durch Erfassen einer Impedanz zwischen einer mit dem Fluid verbundenen Gegenelektrode und einer Messelektrode, die im Inneren der Mikrokavität angeordnet ist. Die Mikrostruktur weist ein Substrat auf, in welchem mindestens eine Mikrokavität ausgebildet ist, wobei im Inneren der Mikrokavität mindestens eine Messelektrode angeordnet ist und wobei ...

Analyseinstrument

Analyseinstrument, mit: einem Substrat (1); einer Vielzahl von Elektroden (11, 12, 13) auf dem Substrat; einer Abdeckung (2); Abstandsmitteln (3), die zwischen dem Substrat und der Abdeckung angeordnet sind, wobei die Abstandsmittel (3) untereinander beabstandete Abschnitte aufweisen; und einer Probenkammer (4, 5), die oben und unten zwischen der Abdeckung (2) und dem Substrat (1) und seitlich zwischen den untereinander beabstandeten Abschnitten der Abstandsmittel (3) definiert ist; wobei die Probenkammer (4, 5) eine Kapillare (5) und einen Flüssigkeitssammelabschnitt (4) mit gekrümmten Seitenwänden aufweist, der mit der Kapillare (5) in Verbindung ist und einen Abschnitt aufweist, der breiter als die Kapillare (5) ist.

Vorrichtung und Verfahren zum gleichzeitigen Testen der Einwirkung von Flüssigkeiten auf Flächengebilde sowie Verwendung der Vorrichtung

Die Erfindung betrifft eine Vorrichtung zum gleichzeitigen Testen der Einwirkung von Flüssigkeiten auf ein oder mehrere Flächengebilde (5), die mindestens ein zusammenhängendes Element (2) mit einer Vielzahl von Kammern, eine Abdeckung (1) zum Verschließen dieser Kammern und einen Antrieb zum Bewegen des Elements (2) umfaßt und die dadurch gekennzeichnet ist, daß eine gleichmäßige Erwärmung der Flüssigkeiten in den Kammern mit mehr als 1 DEG C/s erreicht werden kann.

Vorrichtung und Verfahren zum gleichzeitigen Testen der Einwirkung von Flüssigkeiten auf Flächengebilde sowie Verwendung der Vorrichtung

Vorrichtung zum gleichzeitigen Testen der Einwirkung von Flüssigkeiten auf ein oder mehrere Flächengebilde (5) umfassend mindestens ein zusammenhängendes Element (2) mit einer Vielzahl von Kammern, eine Abdeckung (1) zum Verschließen dieser Kammern und einen Antrieb zum Bewegen des Elements (2), wobei das Flächengebilde (5) zwischen dem Element (2) und der Abdeckung (1) im Bereich der Vertiefungen (3, 4) anzuordnen ist, dadurch gekennzeichnet, daß die Abdeckung (1) und das Element (2) aus einem mit Mikrowellenstrahlung aufheizbaren Werkstoff bestehen, so daß unter Verwendung eines Mikrowellengeräts eine gleichmäßige Erwärmung der Flüssigkeiten in den Kammern mit mehr als 1°C/s erreicht werden kann ...

A biological sample collection and / or storage device

Microfluidic device and a method of loading fluid therein

A microfluidic active matrix electro wetting on dielectric device (AM-EWOD) and a method of filling such a device, wherein the device comprises a chamber 109 having one or more inlet ports 111 and is configured that when the chamber contains a metered volume of a filler fluid 107 it is partially filled and the further addition of a volume of assay fluid 108 into the chamber via one or more of the inlet ports results in the displacement a volume of a venting fluid to vent from the chamber. The venting fluid may be air and the device may comprise a venting channel 115. The assay fluid within the chamber may be controlled by the actuation of electrodes. Alternatively, the chamber is completely filled with filler fluid and when assay fluid is added a sufficient amount of filler fluid is extracted.

Bacteriological MPN strip

This invention is a convenient device for the enumeration of micro- organisms in liquids or suspensions. It consists of a plastic screw capped container having septa, for the division of the sample into appropriate volumes, and Durham tubes moulded in. It contains a sterile growth medium in lyophilised, powder or tablet form. The container is aseptically filled with sample to a line marked on its side, agitated to dissolve the medium and layed flat on a plane surface. It is then rotated through 90 DEG about its long axis so that the desired volumes of sample are separated into their respective compartments. The Durham tubes are designed so that air escapes from them during this operation. Incubation may begin immediately using a portable incubator if necessary. The device was conceived with potable water bacteriology in mind but many other possible applications exist.

Additive channels

Microfluidic device and a method of loading fluid therein

New test device for mass screening

COAGULATING TEST SYSTEM

MICRO ARRAY DEVICES WITH CONTROLLABLE REACTION VOLUME

VORRICHTUNG ZUR MESSUNG DER MIGRATIONSFÄHIGKEIT VON AMÖBOID BEWEGLICHEN ZELLEN

HYBRIDIZING DEVICE

PROCEDURE FOR THE POSITIONING AND ATTACHMENT OF AN OBJECT IN ANOTHER OBJECT

HANDLING SET FOR THE ANALYSIS OF A LIQUID SAMPLE BY NUCLEIC ACID AMPLIFICATION

PROCEDURE AND DEVICE FOR TAKING A CERTAIN QUANTITY PLASMA FROM A BLOOD TEST FOR THE ANALYSIS.

PROCEDURE AND EQUIPMENT FOR THE SEPARATION OF A BODY FLUID FROM PARTICLES IN THIS LIQUID AND TEST RECORD FOR THIS SEPARATION AND ANALYSIS OF THE BODY FLUID.

DEVICE AND PROCEDURE FOR THE ANALYSIS OF LIQUID SAMPLES

CARTRIDGE FOR BIOLOGICAL SAMPLE

Oriented Loading Systems And Method For Orienting A Particle Loaded In A Well

An oriented loading system is provided. The oriented loading system includes a substrate, a plurality of wells formed in the substrate, each well having a bottom and sidewalls, a plurality of particles loaded in the wells, wherein the particle comprises a core structure and an inner layer comprising magnetic material partially covering the core structure such that a part of the core structure uncovered by the inner layer is exposed, and a metal layer comprising magnetic material deposited partially in the sidewalls of the wells, wherein the inner layer is attracted by the metal layer such that the exposed core structure is oriented towards the bottom of the well or the inner layer is oriented towards the bottom of the well.

INSTRUMENT FOR ANALYTICAL SAMPLE PREPARATION

INSTRUMENT FOR ANALYTICAL SAMPLE PREPARATION Abstract An instrument (30) for extraction based molecular sample preparation and related processes is disclosed. The instrument (30) includes a thermally conductive pressure resistant heating chamber (42) and a thermally conductive sample cup (45) positioned in the thermally conductive pressure resistant heating chamber (42) for heating liquids and solids together in the thermally conductive sample cup. A liquid delivery inlet fixture in the thermally conductive pressure resistant heating chamber delivers liquids (solvent) from a supply to the thermally conductive sample cup in the thermally conductive pressure resistant heating chamber, and a chiller in liquid communication with the thermally conductive sample cup in the thermally conductive pressure resistant heating chamber receives heated liquids from the thermally conductive pressure resistant heating chamber when the chamber is opened to atmospheric pressure. Figure 1 ...

Sample acquiring device holder for a housing of an analysis apparatus

The invention relates to a sample acquiring device holder (3) for a housing (2) of an analysis apparatus (1). The sample acquiring device holder (3) may comprise an activating element (5) and a reception recess (11) for receiving a sample acquiring device (4). A first portion (10) of the activating element (5) may protrude into the reception recess (11), if the activating element (5) is in a non-activating position. The activating element (5) may be adapted to be moved into an activating position by the sample acquiring device (4), if the sample acquiring device (4) is inserted into an intended measurement position within the reception recess (11). The activating element (5) may be adapted to activate a measurement triggering element (15), if the activating element (5) is in its activating position, such that the measurement triggering element (15) activates a measurement of the analysis apparatus (1).

Microfluidic nucleic acid analysis

Hemostasis analyzer and method

Device for detection of antigens and uses thereof

Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.

Pipette tip handling devices and methods

Pipette tip handling devices and methods

Discussed herein are methods and devices for storing, handling, loading or dispensing of pipette tips. Some embodiments allow repetitive loading of an array of multiple pipette tips that are stored in a nested configuration.

Point-of-care diagnostic systems and containers for same

The present disclosure relates to a medical diagnostic system. In various embodiments, the system includes a housing, a first receptacle in the housing for receiving a reagent container, a second receptacle in the housing for receiving a working fluid and waste container, where the second receptacle is larger than the first receptacle, two reagent access needles positioned and fixed within the first receptacle with each of the two reagent access needles being positioned to access the reagent container, and a working fluid access needle and a waste access needle positioned and fixed within the second receptacle with the working fluid access needle and the waste access needle being positioned to access the working fluid and waste container.

DUAL SAMPLE CARTRIDGE AND METHOD FOR CHARACTERIZING PARTICLE IN LIQUID

APPARATUS AND METHOD FOR ANALYZING A LIQUID SAMPLE

... ²²²A cartridge for separating a desired analyte from a fluid sample has a sample ²flow path and a lysing chamber (86) in the sample flow path. The lysing ²chamber contains at least one filter for capturing cells or viruses from the ²sample as the sample flows through the lysing chamber. Beads are also disposed ²in the lysing chamber for rupturing the cells or viruses to release the ²analyte therefrom. An analyte flow path extends from the lysing chamber and ²diverges from the sample flow path. The analyte flow path preferably leads to ²a reaction chamber for chemically reacting and optically detecting the ²analyte. The cartridge also includes at least one flow controller (e.g., ²valves) for directing the sample into the waste chamber after the sample flows ²through the lysing chamber and for directing the analyte separated from the ²sample into the analyte flow path.² ...

MICROFLUIDIC CARTRIDGE WITH PARALLEL PNEUMATIC INTERFACE PLATE

The invention relates to a design of an interface plate (101) between a microfluidic cartridge (100) and an instrument (102) for fluid actuation in the disposable cartridge. Pneumatic actuation is carried out through a reversible pneumatic interconnection between instrument and cartridge. Pneumatic drivers are integrated in the instrument for a low cost and reliable solution. The actuation of the fluid in the cartridge is achieved by a flexible membrane (105) attached to the major surface of the disposable cartridge forming closed compartments only when attached to the instrument. The pressure, in these compartments determines the deflection of the membrane which in turn actuates the fluid. This approach takes advantage of the high power and large stroke of pneumatic actuation while at the same time keeping the disposable cartridge simple and low cost and allowing easy introduction of other physical transport across the interface plate, like heat or acoustic vibration. A large number of ...

SLIP CHIP DEVICE AND METHODS

A device is described having a first surface having a plurality of first areas and a second surface having a plurality of second areas. The first surface and the second surface are opposed to one another and can move relative to each other from at least a first position where none of the plurality of first areas, having a first substance, are exposed to plurality of second areas, having a second substance, to a second position. When in the second position, the plurality of first and second areas, and therefore the first and second substances, are exposed to one another. The device may further include a series of ducts in communication with a plurality of first second areas to allow for a substance to be disposed in, or upon, the plurality of second areas when in the first position.

PROCESS AND DEVICE FOR THE SEPARATION OF A BODY FLUID FROM PARTICULATE MATERIALS

The present invention deals with a process and device for the separation of a body fluid from particulate materials in the fluid to be used for a chemical analysis of the fluid components. The process and device are in particular suitable for the separation of plasma from whole blood. Furthermore the present invention relates to a testing kit for the above mentioned separation and analysis purposes. The device has a collector membrane of defined capacitity which intimately contacts the small pore side of a separator membrane having asymmetric pores passing through it, permitting the application of blood to the large pore side of the separator membrane. Because of the simplicity of the present process and device as well as the testing kit a routine examination may be carried out not only in clinical laboratories but also by general practitioners.

CASSETTE STACK HAVING CASSETTES FOR HISTOLOGICAL PREPARATIONS

A cassette stack (1) made up of individual plastic cassettes (2) connected detachably to one another, which are provided for the processing of histological preparations for subsequent section preparation, is described. The cassette stack (1) is insertable into a stack magazine (3) of a printing system, and the individual cassettes (2) are connected to one another via at least one adhesive tape (4) and/or via at least one weld seam (5).

METHODS FOR MANUFACTURING A MICROFLUIDIC ROTOR DEVICE

Described herein are various embodiments directed to rotor devices, methods, and systems. Embodiments of rotors disclosed herein may be used to characterize one or more analytes of a fluid. A manufacturing method may include bonding a first layer and a second layer using two-shot injection molding. The first layer coupled to the second layer collectively defines a set of wells or cuvettes. The first layer is substantially transparent. The second layer defines a channel. The second layer is substantially absorbent to infrared radiation and may comprise some amount of carbon black or of a laser absorbing dye. A third layer is bonded to the second layer using infrared radiation, e.g. using a near-infrared radiation at a wavelength of about 940 nm. The third layer defines an opening configured to receive a fluid and is substantially transparent. The channel establishes a fluid communication path between the opening and the set of wells. By combining injection molding and laser welding techniques ...

MICROFLUIDIC PLATFORM FOR INVESTIGATING CELL-BASED INTERACTIONS

A microfluidic platform (10) for investigating cell-based interactions in accordance with the invention, includes comprises a chip base (12) made of a suitable plastics material with the appropriate optical properties. The chip base (12) has a plurality of ports (14) in fluid communication with a microfluidic channel (16) for containing a culture medium in which cells are held. Preferably a gas permeable laminate (20) is bonded to a bottom surface of the chip base (12). Each port 14 has an internal inlet (22), connecting the port (14) with the microfluidic channel (16), and a trough (24) for containing a small reservoir of culture medium fluid adjacent to the inlet (22) wherein, in use, culture medium can be aspirated from the microfluidic channel via the trough rather than directly via the internal inlet.

ANALYSIS DEVICE AND METHOD FOR TESTING A SAMPLE

An analysis device and method for testing a biological sample by means of a receivable cartridge are proposed, the analysis device comprising at least one actuator for actuating a valve of the cartridge. The actuator comprises a pneumatically loaded membrane and an actuation element that is coupled to said membrane, the return movement into an unactuated position being performed preferably as a result of restoring forces of the membrane.

ASSAY CARTRIDGES AND METHODS OF USING THE SAME

Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.

CHIP ASSEMBLY FOR MEASURING ELECTROCHEMICAL REACTION ON SOLID-LIQUID PHASE INTERFACE IN SITU

A chip assembly for measuring an electrochemical reaction on a solid-liquid phase interface in situ, comprising a first electrode (310), a second electrode (320), a first insulating film (510), a second insulating film (520), a third insulating film (530), a fourth insulating film (540) and an upper chip (100) and a lower chip (200) which are oppositely arranged and of which two sides are correspondingly combined in a sealing manner; a through hole (110) is provided on the upper chip (100); the first insulating film (510) under the through hole (110) is provided with the first electrode (310); a groove (210) opposite to the through hole (110) is provided on the lower chip (200); and the fourth insulating film (540) arranged at one side of the groove (210) is provided with the second electrode (320). The chip assembly dispenses with a specially-made sample rod, thereby substantially reducing test cost; and meanwhile, a lattice structure of a first electrode is also beneficial for observing ...

INCUBATION TRAY

The invention relates to an incubation tray having a depression formed by the walls of the incubation tray and having a base, wherein the incubation tray has a means for drawing off liquid on at least one longitudinal end of the depression, preferably an opening which opens into an outlet channel on the longitudinal end of the depression, particularly preferably in a wall of the incubation tray, wherein the opening and the outlet channel are designed such that negative pressure can be applied, wherein the incubation tray is pivotable about the transverse axis of the incubation tray, and wherein the incubation tray can be equipped with a support.

THERMAL CYCLING APPARATUS AND METHOD

A thermal cycling apparatus having a sample interfacing wall extending from a mounting wall. The sample interfacing wall can accept and apply thermal cycles to samples. An air source can direct an air stream to cool the sample. Another source can direct heated air away from the sample.

DEVICE FOR THE CAPILLARY LIQUID TRANSPORT

The invention relates to a device for the capillary transport of a liquid between two opposite lying, essentially planar layers, whereby both layers are arranged at a distance from and parallel to one another in such a way that a capillary active gap is created between both layers. The invention is characterized in such a way that at least one of the layers comprises at least two discrete adjacent parts, and that the capillary active transport of the liquid can flow beyond the common boundary of the parts which are situated in a layer.

Packaging for analytical samples

Control device for relative humidity.

Ein Steuergerät (100) für relative Feuchtigkeit zum Steuern der relativen Feuchtigkeit in einem Gasraum, umfassend eine Vernebler-Quelle, die einen Auslass (12) für vernebelte Flüssigkeit hat, einen Rahmen (30), bevorzugt einen eine geschlossene Schleife bildenden Rahmen, der einen offenen Bereich umgibt und eine Öffnungsanordnung (33) zum offenen Bereich und in Durchfluss-Wirkverbindung mit dem Auslass umfasst, eine Strömungs-Antriebs-Anordnung (50), die einen Gasfluss von dem Auslass zu der und aus der Öffnungsanordnung hinaus erzeugt. Weiter im Rahmen der Erfindung liegen ein Liquid-Handling-Roboter umfassend das Gerät, ein Betriebsverfahren des Geräts, ein Immunoassay-Verfahren, ein Immunoassay-Gerät und ein Verfahren zur Steuerung des Zeitverlaufs der relativen Feuchtigkeit in einem gashaltigen Raum und ein Verfahren zur Herstellung eines vorgegebenen Volumens einer Flüssigkeit.

Controller for relative humidity.

Ein Steuergerät (100) für relative Feuchtigkeit zum Steuern der relativen Feuchtigkeit in einem Gasraum, umfassend eine Vernebler-Quelle, die einen Auslass (12) für vernebelte Flüssigkeit hat, einen Rahmen (30), bevorzugt einen eine geschlossene Schleife bildenden Rahmen, der einen offenen Bereich umgibt und eine Öffnungsanordnung (33) zum offenen Bereich und in Durchfluss-Wirkverbindung mit dem Auslass umfasst, eine Strömungs-Antriebs-Anordnung (50), die einen Gasfluss von dem Auslass zu der und aus der Öffnungsanordnung hinaus erzeugt. Weiter im Rahmen der Erfindung liegt ein Liquid-Handling-Roboter, umfassend das Gerät, ein Betriebsverfahren des Geräts, ein Immunoassay-Verfahren und Verfahren zur Steuerung des Zeitverlaufs der relativen Feuchtigkeit in einem gashaltigen Raum und zur Herstellung eines vorgegebenen Volumens einer Flüssigkeit.

Probebehälteraufnahmevorrichtung und Kalorimeter.

Eine erfindungsgemässe Probebehälteraufnahmevorrichtung (30) enthält ein Grundelement (31), welches zur Aufnahme eines Probebehälters ausgebildet ist, wobei das Grundelement (31) eine Ausnehmung (32) enthält, welche zur Aufnahme des Probebehälters ausgebildet ist. Das Grundelement (31) umfasst eine Grundfläche (33) und eine Deckfläche (36), wobei die Grundfläche (33) gegenüberliegend zur Deckfläche (36) angeordnet ist. Die Ausnehmung (32) erstreckt sich von der Grundfläche (33) zur Deckfläche (36), wobei die Grundfläche (33) und die Deckfläche (36) in einem Abstand (H) zueinander angeordnet sind. Die Ausnehmung (32) weist eine Ausnehmungsbreite (AB) und eine Ausnehmungslänge (AL) auf. Die Ausnehmungsbreite AB der Ausnehmung (32) auf einer der Grundflächen (33) oder Deckflächen (36) ist kleiner als in einer Zwischenfläche (37), welche sich zwischen der Grundfläche (33) und der Deckfläche (36) erstreckt. Die Erfindung betrifft auch ein Kalorimeter mit einer Aufnahme für Probebehälter.

Sample container receiving device and calorimeter.

Eine erfindungsgemässe Probebehälteraufnahmevorrichtung (30) enthält ein Grundelement (31), welches zur Aufnahme eines Probebehälters ausgebildet ist, wobei das Grundelement (31) eine Ausnehmung (32) enthält, welche zur Aufnahme des Probebehälters ausgebildet ist. Das Grundelement (31) umfasst eine Grundfläche (33) und eine Deckfläche (36), wobei die Grundfläche (33) gegenüberliegend zur Deckfläche (36) angeordnet ist. Die Ausnehmung (32) erstreckt sich von der Grundfläche (33) zur Deckfläche (36), wobei die Grundfläche (33) und die Deckfläche (36) in einem Abstand H zueinander angeordnet sind. Die Ausnehmung (32) weist eine Ausnehmungsbreite AB und eine Ausnehmungslänge AL auf. Die Ausnehmungsbreite AB der Ausnehmung (32) auf einer der Grundflächen (33) oder Deckflächen (36) ist kleiner als in einer Zwischenfläche (37), welche sich zwischen der Grundfläche (33) und der Deckfläche (36) erstreckt. Die Erfindung betrifft auch ein Kalorimeter mit einer Aufnahme für Probebehälter.

Support plate for laboratory equipment.

Die Erfindung ist auf dem Gebiet der Laborgeräte und Laborvorrichtungen angesiedelt und bezieht sich insbesondere auf eine Trägerplatte, welche beispielsweise innerhalb eines Elektrophorese-Verfahrens zum Einsatz kommt, und auf eine auf die Trägerplatte abgestimmte Haltevorrichtung. Eine erfindungsgemässe Trägerplatte 1 ist für eine Verwendung in einem Laborgerät eingerichtet. Die Trägerplatte 1 weist einen Bereich mit einer magnetischen Eigenschaft und eine Positionierungsvorrichtung auf und ist dadurch gekennzeichnet, dass die magnetische Eigenschaft ausgebildet ist, die Trägerplatte 1 im Laborgerät zu fixieren und dass die Positionierungsvorrichtung ausgebildet ist, eine Position der Trägerplatte 1 im Gerät zu garantieren.

DEVICE AND METHOD OF CYCLIC TEMPERATURE CHANGE

FLASK FOR REAGENTS WITH SUCTION TUBE OF

TOOL FOR CARRYING OUT DIAGNOSTIC TESTING ON CARTRIDGE FOR FLUID MEDIUM

Optical indicator for detecting bacterial pathogens

A clinical testing assay device that can differentiate bacterial from viral infections is described. The assay device has a sample contact zone with an absorbent pad on which a test sample is deposited and a detection zone with a colorant indicator that is sensitive to bacteria cells. The colorant indicator changes color when exposed to a bacteria sample. The color change signal can manifest relatively quickly, usually within a few minutes, and with an intensity correlative to the concentration of bacteria in a test sample. A method of use is also provided.

Multi-through hole testing plate for high throughput screening

Apparatus and method for quantifying cells and non-cellular blood components

Polydimethylsiloxane (PDMS) template and preparation method thereof as well as preparation method of array type liquid drop-in-oil structure

PROCEDE POUR LE CHARGEMENT DE CUVETTES DANS UN INSTRUMENT, ET EMBALLAGE DE CUVETTE

LA PRESENTE INVENTION EST RELATIVE A UN PROCEDE DE CHARGEMENT DE CUVETTES DANS UN INSTRUMENT. LES CUVETTES SONT TRANSFEREES DANS L'INSTRUMENT PENDANT QUE L'EMBALLAGE 1 EST FIXE A L'OUVERTURE D'ENTREE DE L'INSTRUMENT, PAR POUSSEE A L'ARRIERE DE LA RANGEE DE CUVETTES 3 PLACEES DANS L'EMBALLAGE, AU MOYEN DU COUVERCLE DETACHABLE 2 DE L'EMBALLAGE. APPLICATION AUX CUVETTES DESTINEES AUX ANALYSES CHIMIQUES ETOU A LA MANIPULATION DE LIQUIDES.

MICROBIOLOGICAL REACTION CHAMBER APPARATUS

PROCESS AND DEVICE TO DELIVER A QUANTITY PREDETERMINEE OF PLASMA STARTING FROM A SAMPLE OF BLOOD FOR ANALYSES.

METHOD AND DEVICE FOR FLOWING A LIQUID ON A SURFACE

A device for flowing a liquid on a surface comprises: a flow path (40). A first port (20) supplies the liquid to one end of the flow path and applies a fist port pressure for retaining the liquid when the flow path is remote from the surface (80). A second port (30) receives the liquid from the other end of the flow path (40) and applies a second port pressure such that the difference between the first and second negative port pressures is oriented to pormote flow of the liquid from the first port (20) to the second port (30) via the flow path (40) in response to the flow path (40) being located proximal to the surface (80) and the liquid in the device contacting the surface (80). The first and the second port pressures are such that the liquid is drawn towards at least the second port in response to withdrawal of the flow path from the surface. Such devices may employ microfluidic technology and find application in surface patterning. © KIPO & WIPO 2007 ...

device for charging plates reagent [...] analyzers

System for conducting the identification of bacteria in biological samples

REACTION VESSEL AND METHOD OF DNA AMPLIFICATION REACTION

Linear recess is provided on the back of synthetic resin substrate (1). The linear recess is sealed with film (3) so as to form tunnellike reaction chamber (12) surrounded by the film (3) and the substrate. Further, the film (3) is caused to undergo an ingress from the back surface of the substrate (1) into the side of reaction chamber (12) so as to form protrudent part (31). The evaporation of reagents, etc. can be suppressed. Moreover, the occurrence of any gap attributed to a difference of thermal expansion coefficient between the substrate (1) and the film (3) is limited to the side wall of the reaction chamber (12) and the protrudent part (31) of the film (3), so that a satisfactory amount of reaction product can be obtained through prevention of any reduction thereof.

Centrifuge tube holding assembly

The panel has measurement indicia thereon configured to be positioned to be alignable with the ultracentrifuge tube.

Device for analyzing a fluid sample

The present invention provides a cartridge for analyzing a fluid sample. The cartridge provides for the efficient separation of cells or viruses in the sample from the remaining sample fluid, lysis of the cells or viruses to release the analyte (e.g., nucleic acid) therefrom, and optionally chemical reaction and/or detection of the analyte. The cartridge is useful in a variety of diagnostic, life science research, environmental, or forensic applications for determining the presence or absence of one or more analytes in a sample.

BIOCHIP SUPPORT MEMBER, METHOD FOR MANUFACTURING BIOCHIP SUPPORT MEMBER, BIOCHIP PACKAGE, SCREENING DEVICE, AND SCREENING METHOD

A biochip support member is provided that comprises a base material, and a columnar member different member from the base material having a support area that can support a biochip formed of a biomolecule provided at one end, and is attached to the base material through an attaching part at the other end.

MICROFLUIDICS SORTER FOR CELL DETECTION AND ISOLATION

An interface comprising: a plurality of external ports configured to fluidically communicate with a plurality of ports of a fluidic delivery platform; and a plurality of engaging conduits configured to fluidically communicate with a plurality of ports of a microfluidic biochip, wherein a tolerance of both the plurality of external ports and/or the plurality of engaging conduits is significantly tighter than a tolerance of the plurality of ports of the microfluidic biochip.

Unitary cartridge for particle processing

A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles.

REAGENT SUPPLYING DEVICE

Provided are a reagent supply method and device capable of using up a reagent in a container without a remnant to the extent possible, and supplying the reagent to an analysis device without mixing air bubbles even when the remaining amount of the reagent is extremely small. The reagent supply device includes: at least one reagent container including: a container body for storing a liquid reagent; and a reagent supply port arranged on the container body; and a support member for supporting the at least one reagent container so that the reagent supply port is positioned on a lower side of the container body. The reagent supply port is sealed by a plug including at least one nozzle penetration portion. The at least one nozzle penetration portion is formed of a material having a Shore hardness of from A5° to A90°.

Temperature controller for structure

A temperature controller for controlling temperature of a first structure having a first flat face comprises a second structure having a second flat face for planar contact with the first flat face, a pressure-applying means for pressing the first structure, a second supporting means for supporting the second structure to be capable of changing inclination of the second flat face, a first supporting means for supporting the first structure by contact with a portion of the first structure other than the first flat face, and a temperature-controlling means, wherein the first structure is supported by pressing the first structure by the pressure-applying means, and the second structure is brought into contact with the temperature-controlling means with interposition of the second supporting means.

Microfluidic device for separating and sorting particles in a fluid medium

A microfluidic device for separating emulsion solution into separate particles by passing the emulsion solution through a passive filter. The separated particles can then be sorted into separate chambers through active filtering.

CARTRIDGES, KITS, AND METHODS FOR ENHANCED DETECTION AND QUANTIFICATION OF ANALYTES

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Method and apparatus for DNA collection

A device for collection of DNA-containing materials is provided and a method of preventing DNA specimen contamination is provided which prevents extraneous DNA found in DNA evidence collection kits from interfering with DNA specimen analysis, further a device an method is provided for collecting the DNA-containing material of a subject from the subject's skin.

Cuvette For Detecting Bacteria And Determining Their Susceptibility To Antibiotics

A method for detecting and counting particles suspended in fluids, such as bacteria suspended in urine, utilizing dynamic features of the suspended particles and employing light scattering measurements. The disclosed method is suitable for determining the susceptibility of bacteria to antibiotics. A cuvette for detecting bacteria in fluids, which is especially suited for the light scattering measurements, is provided.

Specimen tube holder and shipping container

A shipping container/rack for shipping and holding of specimen or culture tubes is claimed. The invention consists of a hollow housing with a plurality of wells for holding tubes upright during processing of their contents, and separate brackets for securing the tubes during shipment. The housings are joinable front-to-back for creating larger tube storage rack, and housings are also stackable one atop another. The housing provides a secure, shock-proof shipping container during shipping of filled specimen tubes and a convenient tube rack for multiple tubes during insertion, extraction, and processing of tube contents.

RACK

A rack for holding assay tips with improved stacking is provided. The rack has guiding elements arranged near opposing edges of at least two substantially orthogonal side walls of the peripheral wall of the rack configured to provide an early alignment of the rack with a similar rack, such that assay tips received in the rack nest into the assay tips received in the similar rack when the racks are stacked. 1. A rack for holding assay tips , the rack comprising:a surface plate, the surface plate comprising assay tip through boreholes extending substantially in a Z direction orthogonal to the surface plate, the assay tip through boreholes having seating areas for receiving assay tips in the rack;a peripheral skirt extending from a periphery of the surface plate substantially in the Z direction; andat least four guiding elements extending substantially in the Z direction, a first pair of the four guiding elements being respectively arranged near opposing edges of a first side wall of the peripheral skirt and a second pair of the four guiding elements being respectively arranged near opposing edges of a second side wall of the peripheral skirt, substantially orthogonal to the first side wall,wherein each guiding element comprises a slit and a corresponding rail, the guiding elements arranged such that the rail of the rack is guided into a corresponding slit of a similar rack thereby aligning the rack and a similar rack and such that assay tips received in the assay tip through boreholes of the rack nest into the assay tips received in assay tip through boreholes of the similar rack when the racks are stacked.2. A rack according to claim 1 , wherein each rail comprises a pair of ribs configured to slide in between the respective slit of the similar rack when the racks are stacked.3. A rack according to claim 2 , wherein the peripheral skirt is tapered outwards such that a lower part of the peripheral skirt of an upper rack accommodates an upper part of the similar rack ...

AN ALIQUOTING AND FREEZING STORAGE DEVICE

An aliquoting and freezing storage device comprises a test tube and at least one capillary tube. The capillary tube is inserted into a test tube, and the capillary tube is provided with an inner long hole which penetrates throughly. The device utilizes the capillarity to quickly and easily store biological samples in the capillary tubes. When needed, the operator only needs to remove one or several of the tubes, without affecting the remaining biological samples, so as to avoid repeated freezing and thawing of biological samples.

CARTRIDGE FOR STORING BIOSAMPLE CAPILLARY TUBES AND USE IN AUTOMATED DATA STORAGE SYSTEMS

Embodiments of the disclosure relate to a cartridge that includes slots for storing biosample capillary tubes. The cartridge has the same form factor as data tape cartridges to allow the cartridge to be handled by the same robotic mechanisms that handle data cartridges in an automated tape library. One aspect of the disclosure concerns a cartridge comprising an enclosure that includes a movable door to provide access to a tube holder in the enclosure. The tube holder includes cylindrical holes or slots for receiving capillary tubes which contain biosamples scanned and analyzed an automated tape library.

Apparatus for temperature modulation of samples

Embodiments described herein relate to apparatus for temperature modulation of samples. Generally, aspects of the disclosure provide for a portable cooling and heating apparatus which enables a user to visualize a sample during cooling or heating. In one embodiment, the apparatus include a sample block, a plurality of thermoelectric modules coupled to the sample block, and a cooling block coupled to the plurality of thermoelectric modules. In another embodiment, the cooling block is in fluid communication with a fluid reservoir. Other embodiments utilize various insulating materials to influence thermal conductivity between the sample block and the cooling block to provide for enhanced temperature control and modulation.

Multi-dimensional double spiral device and methods of use thereof

Described is a multi-dimensional double spiral (MDDS) microfluidic device comprising a first spiral microchannel and a second microchannel, wherein the wherein the first spiral microchannel and second spiral microchannel have different cross-sectional areas. Also described is a device comprising a multi-dimensional double spiral and system for recirculation. The invention also encompasses methods of separating particles from a sample fluid comprising a mixture of particles comprising the use of the multi-dimensional double spiral microfluidic device.

A QPCR ANALYSIS APPARATUS

DEVICE AND METHOD FOR STANDARDIZING NUCLEIC ACID CONCENTRATIONS

REAGENT RECEPTACLE FOR USE IN BIOLOGICAL SAMPLE ANALYSIS DEVICE AND METHOD FOR MANUFACTURING REAGENT RECEPTACLE

A reagent container for a biological sample analyzer that has higher impact resistance than a conventional one and a method for manufacturing the reagent container are provided. The reagent container for a biological sample analyzer is formed of a paper sheet member and has a bottom surface and side wall surfaces connected to the bottom surface. The bottom surface is formed by folding one end side of a tubular body with a prismatic tubular shape formed of the sheet member and adhering overlapping surfaces to each other, and the overlapping surfaces are not adhered to each other in a predetermined region including an apex of the bottom surface.

MICROARRAY DEVICES HAVING CONTROLLABLE REACTION VOLUME

PROTEASE DETECTION

MICROFLUIDIC DEVICE

Cassette-stack with cassettes for histological examinations

プロテアーゼ検出

... 発色性アミノ酸を含むポリペプチド。該発色性アミノ酸がそのNおよびC末端において少なくとも1つのアミノ酸に隣接している。該発色性アミノ酸のアミン基は5未満のpKaを有する。該発色性アミノ酸は共役アルデヒドと反応可能である。該ポリペプチドは、該発色性アミノ酸のアミノ基を含むペプチド結合を切断しうる標的プロテアーゼに対する標的配列を含む。 ...

Multi-task immunoaffinity device secured to a peripheral box and integrated to a capillary electrophoresis apparatus

The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as a modular, multi-task immunoaffinity device secured to a peripheral box and connected to capillary electrophoresis or liquid chromatography for the isolation, enrichment, separation and identification of polymeric macromolecules, primarily protein biomarkers. In one embodiment, two devices are coupled in-tandem to perform separately and sequentially microreactions and concentrations of proteins. In this embodiment, biological samples containing proteins can be subjected to proteolytic processing in the first device, and the resulting peptides subjected to selective purification and concentration in the second device.

Cell concentration, capture and lysis devices and methods of use thereof

The present invention provides a microfluidic devices and methods of use thereof for the concentration and capture of cells. A pulsed non-Faradic electric field is applied relative to a sample under laminar flow, which results to the concentration and capture of charged analyte. Advantageously, pulse timing is selected to avoid problems associated with ionic screening within the channel. At least one of the electrodes within the channel is coated with an insulating layer to prevent a Faradic current from flowing in the channel. Under pulsed application of a unipolar voltage to the electrodes, charged analyte within the sample is moved towards one of the electrodes via a transient electrophoretic force.

Biosample plate with data storage and wireless communication means

Embodiments of the disclosure relate to a biosample plate that includes a memory component for storing information related to the biosample, biosample plate and biosample analysis data, and a wireless communication interface for transferring information to and from the biosample plate. The biosample plate may be used with an analyzing and data recording system such as an electromagnetic tape drive. The disclosed biosample plate facilitates the correlation between a large number of biosample plates and data as data remains with the corresponding biosamples both when the biosample plates are in use and when they are in storage. The wireless communication interface may comprise an antenna disposed in a biosample plate for data transmission to and from the biosample plate by radio signals.

Enzyme detection

An enzyme detection product ( 1 ) for detecting the presence of an enzyme in a sample. The product ( 1 ) comprises: a reaction zone ( 16 ) for receiving the sample; a visualization zone ( 10 ) for presenting a signal in response to the detection of the activity of the enzyme; and a membrane ( 11 ). The membrane ( 11 ) is interposable between the reaction zone ( 16 ) and the visualization zone ( 10 ) and prevents passage from the reaction zone ( 16 ) to the visualization zone ( 10 ) the components having a size greater than a threshold size. The reaction zone ( 16 ) comprises a reactant capable of reacting with the enzyme in order to generate a reaction product having a size less than a threshold size.

Microfluidic cartridge for processing and detecting nucleic acids

A microfluidic cartridge, configured to facilitate processing and detection of nucleic acids, comprising: a top layer comprising a set of cartridge-aligning indentations, a set of sample port-reagent port pairs, a shared fluid port, a vent region, a heating region, and a set of Detection chambers; an intermediate substrate, coupled to the top layer comprising a waste chamber; an elastomeric layer, partially situated on the intermediate substrate; and a set of fluidic pathways, each formed by at least a portion of the top layer and a portion of the elastomeric layer, wherein each fluidic pathway is fluidically coupled to a sample port-reagent port pair, the shared fluid port, and a Detection chamber, comprises a turnabout portion passing through the heating region, and is configured to be occluded upon deformation of the elastomeric layer, to transfer a waste fluid to the waste chamber, and to pass through the vent region.

Microdroplet/bubble-producing device

The invention provides a microdroplet- or bubble-producing device that does not require separate through-holes for different liquid droplet/air bubble-producing flow channels. The droplet-producing flow channels are configured in a three-dimensional manner unlike in a conventional device where they are configured in a two-dimensional plane, and therefore the flow channels can be provided in a more high-density configuration than the prior art. In the microdroplet/bubble-producing device comprising slit(s) and the row of the plurality of microflow channels, the slit(s) is/are a continuous phase supply slit, a dispersion phase supply slit and a discharge slit, the plurality of microflow channels are configured so that the ends of the slit(s) and the two supply ports on both sides or the supply port and discharge port on either side are mutually connected, and at the sites of connection between the microflow channels and the slit(s), the dispersion phase undergoes shear with the continuous phase flow as the driving force, producing droplets or air bubbles of the dispersion phase, which are recovered from the discharge port.

Microscope Slide File Position Flag and Method Related Thereto

The present invention describes a flag, or marker for identifying the locations of a plurality of microscope slides once removed from their storage locations within a microscope slide storage system. The invention comprises a molded polymer rectangular cuboid body member with rectangular front, rear, top, left, right, and bottom surfaces which follows the shape of a glass microscope slides, and the locations contained within a microscope slide storage system, with a recessed groove to accept one slide index marker card for recording the patient's case information, or other relevant information, and offers hard surfaces for recording additional identification modalities, which additionally provides a support structure for the neighboring microscope glass slides contained within said storage location. 1: A microscope slide file position flag comprise:11.: A body member having a front and opposing parallel rear surfaces spaced apart equal to a predetermined plurality thickness of stacked microscope slides with cover glass , whereby the front and rear surface maintain the correct spacing within the void created when a plurality of specimen microscope slides are removed from a vertically or horizontally orientated microscope slide filing storage system.12.: A body member here described is best defined as a rectangular cuboid block as it follows the inherent shape of tissue cassettes , with other geometric shapes providing the same opposing surfaces to fill voids created from withdrawn tissue blocks within a storage system , including cylinders , elongated spheres , rounded cubes , or any other physical form.13.: Within the body member provisions are incorporated into its surfaces to receive one slide index card , whereby the slide index card is visible on one of its front surfaces , or other provisions for writing or recording pertinent patent information onto any of the surfaces , can be incorporated into the final design.14.: Other identification mechanisms may be ...

Filtration device with multiple post-filtration orientations

A cell filtration assembly adapted to capture cells from a biological sample during centrifugation includes a centrifugation tube, a cell collection device adapted to be secured within a tapered end of the centrifugation tube and a funnel structure adapted to direct fluid into the cell collection device. The cell collection device includes a rectilinear structure that is adapted to permit fluid to flow through the rectilinear structure and a cell capture surface that is secured relative to the rectilinear structure. The cell collection device may be sectioned in either a horizontal or vertical orientation.

MICROFABRICATED DEVICE WITH MICRO-ENVIRONMENT SENSORS FOR ASSAYING COAGULATION IN FLUID SAMPLES

The present invention relates to sample analysis cartridges comprising micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using micro-environment sensors in a point of care sample analysis cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample, and a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber. The conduit may include a micro-environment prothrombin time (PT) sensor, and a micro-environment activated partial thromboplastin time (aPTT) sensor. 1. An integrated circuit chip comprising:a micro-environment prothrombin time (PT) sensor;a micro-environment activated partial thromboplastin time (aPTT) sensor or an micro-environment activated clotting time (ACT) sensor, wherein the micro-environment PT sensor is on a same vertical plane as the micro-environment aPTT sensor or the micro-environment ACT sensor;a first temporary electrical connector connected via a wiring to the micro-environment PT sensor; anda second temporary electrical connector connected via another wiring to the micro-environment aPTT sensor or the micro-environment ACT sensor.2. The integrated circuit chip of claim 1 , wherein the micro-environment PT sensor comprises at least one reagent for inducing extrinsic coagulation pathway.3. The integrated circuit chip of claim 1 , wherein the micro-environment aPTT sensor or the micro-environment ACT sensor comprises at least one reagent for inducing intrinsic coagulation pathway.4. The integrated circuit chip of claim 1 , wherein the micro-environment PT sensor is an amperometric PT sensor claim 1 , wherein the micro-environment aPTT sensor is an amperometric aPTT sensor claim 1 , wherein the micro-environment ACT sensor is an amperometric ACT sensor claim ...

Kit Including Planar Sample Carrier with Absorbent Membrane Layer and Box

A kit or set including a planar sample carrier having an absorbent membrane layer suitable for absorbing liquid blood components is provided, and wherein at least a portion of the blood components is able to dry in the membrane layer, wherein the sample carrier is additionally provided on an outer side with an optically readable code, additionally including a closable cuboidal box having a bottom surface that has a rectangular base surface and that additionally has a first opening, additionally including a planar receiving element having a base surface that corresponds to the base surface of the bottom surface, wherein the receiving element has a second opening and a holder that together are designed such that, on mounting the sample carrier in the holder and subsequently inserting the receiving element into the box on the bottom surface of the box, the optical code is visible through the first opening in the bottom surface and also through the second opening in the receiving element. 114-. (canceled)15. A set comprising: an absorbent membrane layer suitable for absorbing liquid blood components, wherein at least a portion of the blood components is able to dry in the membrane layer; and', 'an outer side comprising an optically readable code;, 'a planar sample carrier comprisinga closable cuboidal box having a bottom surface comprising a rectangular base surface and a first opening; [ 'wherein the holder permits a mechanically reversible mounting of the sample carrier in the holder such that the sample carrier may be removed from the holder without mechanical damage;', 'a separate holder for the sample carrier,'}, 'a base surface that corresponds to the base surface of the bottom surface; and', 'a second opening,', 'wherein, together, the second opening and the holder are designed such that, on mounting the sample carrier in the holder and subsequently inserting the receiving element into the box on the bottom surface of the box, the optical code is visible through ...

ANALYSIS DEVICE, ANALYSIS KIT, AND ANALYSIS SYSTEM

A device including a well array including wells in which a target substance is detected based on a biochemical reaction thereof. Each of the wells has an aspect ratio of 1 or more as calculated by Formula (1) such that the biochemical reaction of the target substance is detected, 1. A device , comprising:a well array including a plurality of wells in which a target substance is detected based on a biochemical reaction thereof, {'br': None, 'Aspect ratio=Depth of each well/Diameter of largest circle among circles included in a region enclosed by a rim of each well\u2003\u2003Formula (1).'}, 'wherein each of the wells has an aspect ratio of 1 or more as calculated by Formula (1) such that the biochemical reaction of the target substance is detected,'}2. The device according to claim 1 , wherein each of the wells has a volume of 100 fL to 5 claim 1 ,000 fL.3. A kit claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the device of ;'}a detection reagent for causing the biochemical reaction of the target substance; anda sealing liquid for sealing the wells.4. A kit claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00002', 'claim 2'}, 'the device of ;'}a detection reagent for causing the biochemical reaction of the target substance; anda sealing liquid for sealing the wells.5. The kit according to claim 3 , wherein the sealing liquid comprises an oil.6. The kit according to claim 4 , wherein the sealing liquid comprises an oil.7. A system claim 4 , comprising:{'claim-ref': {'@idref': 'CLM-00003', 'claim 3'}, 'the kit of ;'}a detector configured to detect the biochemical reaction; andan analysis unit configured to analyze a value measured by the detector.8. The system according to claim 7 , wherein the biochemical reaction is an isothermal reaction.9. The system according to claim 7 , wherein each of the wells has a depth that is larger than a depth of field of the detector and 100 times or less the depth of field.10. The system according to claim 7 , ...

Device And Method For Measuring The Total Organic Carbon Content Of A Sample Fluid

A device for measuring the total organic carbon content (TOC) of a sample fluid comprises a measuring cell (2) defining a volume (3) for containing a sample fluid and an excimer lamp (20) arranged to cause an oxidation reaction of the sample fluid by emitting radiation onto the sample fluid in the volume (3). A pair of electrodes is arranged to measure the conductivity of the sample fluid during the oxidation reaction and at least one temperature senor (31) is arranged on the measuring cell (2) to measure a temperature that is related to the sample fluid. The total organic carbon content (TOC) of the sample fluid is determined on the basis of the measured conductivity compensated by the temperature related to the sample fluid.

REAGENT CONTAINER FOR BIOLOGICAL SAMPLE ANALYZER AND METHOD FOR MANUFACTURING REAGENT CONTAINER

A reagent container for a biological sample analyzer that has higher impact resistance than a conventional one and a method for manufacturing the reagent container are provided. The reagent container for a biological sample analyzer is formed of a paper sheet member and has a bottom surface and side wall surfaces connected to the bottom surface. The bottom surface is formed by folding one end side of a tubular body with a prismatic tubular shape formed of the sheet member and adhering overlapping surfaces to each other, and the overlapping surfaces are not adhered to each other in a predetermined region including an apex of the bottom surface. 1. A reagent container for a biological sample analyzer that is formed of a paper sheet member for housing a reagent to be used in the biological sample analyzer , comprising:a bottom surface; andside wall surfaces connected to the bottom surface,wherein the bottom surface is formed by folding one end side of a tubular body with a prismatic tubular shape formed of the sheet member and adhering overlapping surfaces to each other, andthe overlapping surfaces are not adhered to each other in a predetermined region including an apex of the bottom surface.2. The reagent container for a biological sample analyzer according to claim 1 ,wherein the biological sample analyzer is a hemocyte analyzer for analyzing hemocytes in blood.3. The reagent container for a biological sample analyzer according to claim 2 ,wherein the hemocyte analyzer includes a measurement unit for measuring the hemocytes in blood using flow cytometry.4. The reagent container for a biological sample analyzer according to claim 1 ,wherein the predetermined regions in which the overlapping surfaces are not adhered to each other are separately provided with respect to all of apexes of the bottom surface.5. The reagent container for a biological sample analyzer according to claim 1 ,wherein the predetermined region in which the overlapping surfaces are not adhered to ...

INSTRUMENT FOR PREFORMING A DIAGNOSTIC TEST ON A FLUIDIC CARTRIDGE

Instrument for performing a diagnostic test on a fluidic cartridge A cartridge reader is for carrying out a diagnostic test on a sample contained in a fluidic cartridge inserted into the reader. The fluidic cartridge comprises a fluidic layer comprising at least one sample processing region, at least one collapsible blister containing a liquid reagent, a pneumatic interface, an electrical interface and at least one mechanical valve. The reader comprises a housing; an upper clamp occupying a fixed position relative to the reader, and a lower clamp, movable relative to the first clamp, wherein the upper clamp and the lower clamp define a cartridge receiving region therebetween. The reader comprises a thermal module comprised in the lower clamp, wherein the thermal module comprises at least one thermal stack for heating the at least one sample processing region of the cartridge inserted into the reader. The reader comprises at least one mechanical actuator for actuating the mechanical valve comprised in the cartridge inserted into the reader. 123-. (canceled)24. A fluidic cartridge for carrying out a diagnostic test on a sample contained therein , the cartridge comprising: a housing;', 'an upper clamp occupying a fixed position relative to the reader and a lower clamp movable relative to the upper clamp, wherein the upper clamp and the lower clamp define a cartridge receiving region therebetween, wherein the cartridge receiving region comprises a tray configured to move between an open position and a closed position and to receive a cartridge;', 'a thermal module comprised in the lower clamp;', 'a pneumatics module comprising a plurality of pneumatic interface;', 'at least one mechanical actuator;', 'at least one blister actuator;', 'an electrical module comprising a plurality of pins; and', 'a barcode reader, wherein at least part of each of the pneumatics module, the at least one mechanical actuator, the at least one blister actuator, the electrical module and the ...

Biological sheet fixing device

A biological sheet fixing device includes a carrying layer configured to carry a biological sheet, a carrying portion configured to carry the carrying layer, and a fixing portion configured to fix the carrying layer to the carrying portion.

MICROFLUIDIC NUCLEIC ACID ANALYSIS

Nucleic acid from cells and viruses sampled from a variety of environments may purified and expressed utilizing microfluidic techniques. In accordance with one embodiment of the present invention, individual or small groups of cells or viruses may be isolated in microfluidic chambers by dilution, sorting, and/or segmentation. The isolated cells or viruses may be lysed directly in the microfluidic chamber, and the resulting nucleic acid purified by exposure to affinity beads. Subsequent elution of the purified nucleic acid may be followed by ligation and cell transformation, all within the same microfluidic chip. In one specific application, cell isolation, lysis, and nucleic acid purification may be performed utilizing a highly parallelized microfluidic architecture to construct gDNA and cDNA libraries. 1. A microfluidic apparatus comprising:(a) a solid substrate;(b) a cell separation and processing system embedded in the substrate that includes an arrangement of flow channels configured so that individual cells from a cell population can be singly isolated;(c) one or more inlet channels in the substrate connected with the cell separation and processing system so that a reagent can be delivered through the inlet channel(s) and combined with cells isolated by the system; and(d) one or more outlet channels in the substrate connected with the cell separation and processing system so that contents obtained by lysing isolated cells can be flowed through the outlet channel(s) and kept separate;wherein the apparatus is designed and constructed so that a user can prepare a plurality of cDNA libraries from single cells by a method that comprises:(1) receiving a sample of cells into the cell separation and processing system of the apparatus;(2) processing the sample in the cell separation and processing system such that a plurality of single cells from the sample are fluidically isolated from all other cells in the sample, thereby producing isolated single cells;(3) combining ...

FLUIDIC CHANNEL FOR A CARTRIDGE

A cartridge for collecting sample material may include a cartridge body and a fluid reservoir. The cartridge body may define a capless sample well port configured to receive the sample material and a fluidic channel in fluid communication with the capless sample well port. The fluidic channel may include a sample fluidic channel portion and may be configured such that an effect of gravity on the sample material within the sample fluidic channel portion does not overcome a capillary action of the fluidic channel. The fluidic channel may extend between the capless sample well port and the fluid reservoir. The fluidic channel may be configured to direct the sample material towards the fluid reservoir when a pressure is applied within the fluidic channel. 1. A cartridge comprising:a cartridge body defining a capless sample well port configured to receive a sample material and a fluidic channel in fluid communication with the capless sample well port, wherein the fluidic channel comprises a first fluidic channel portion extending along a first axis and a second fluidic channel portion extending along a second axis, wherein the first axis is at an angle to the second axis; anda fluid reservoir, wherein the fluidic channel extends between the capless sample well port and the fluid reservoir, wherein the fluidic channel is configured to direct the sample material towards the fluid reservoir when a pressure is applied within the fluidic channel.2. The cartridge of claim 1 , further comprising a fluid drive port in fluid communication with the fluidic channel claim 1 , wherein the fluid drive port is configured to be operably connected to a pressure source such that a positive pressure is applied within the fluidic channel to direct the sample material towards the fluid reservoir.3. The cartridge of claim 1 , wherein the first and second fluidic channel portions define a channel depth of less than or equal to 3 mm and a channel width of less than or equal to 3 mm.4. The ...

A Modular Bio-Processing Unit and a Bio-Processing System Employing Plural Units

Disclosed is a modular bio-processing unit () comprising: a housing () having one or more internal fluid paths (), the housing having at least one inlet and at least one outlet (), each in fluid communication with the fluid path or one or more of the fluid paths; one or more sensor elements () operatively associated with the or each path, said sensor(s) elements including elements of one or more of: a flow sensor, a flow rate sensor, a conductivity sensor, a pressure sensor, a pH sensor, and a light absorbance sensor such as a UV spectroscopic concentration sensor; one or more fluid flow inducing components () operatively associated with the or each fluid path; and plural valves () for preventing or reducing flow in the or each path, the housing, inlet(s), outlet(s), flow inducing component(s) and valve(s) being arranged to operate together as a bio-processing unit within or substantially within the housing. 1. A modular bio-processing unit operable with like units to provide a bio-processing system , comprising:a housing having one or more internal fluid paths, the housing having at least one inlet and at least one outlet, each in fluid communication with the fluid path or one or more of the fluid paths;one or more sensor elements operatively associated with the or each path, said sensor(s) elements including elements of one or more of: a flow rate or flow direction sensor, a conductivity sensor, a pressure sensor, a pH sensor, an air trap and a light absorbance sensor such as a UV light absorbance sensor;one or more fluid flow inducing components operatively associated with the or each fluid path; andplural valves for preventing or reducing flow in the or each path, operate together as a bio-processing unit within or substantially within the housing.2. The modular bio-processing unit of claim 1 ,wherein the unit includes a selection valve for selecting input into the path(s) from plural sources.3. The modular bio-processing unit of claim 2 ,wherein the flow ...

CAPLESS SAMPLE WELL PORT FOR A CARTRIDGE

A cartridge for collecting sample material may include a cartridge body, a filter, a fluid reservoir, and a fluid drive port. The cartridge body may define a capless sample well port configured to receive a sample material and a fluidic channel in fluid communication with the capless sample well port. The filter may be positioned between the capless sample well port and the fluidic channel. The fluidic channel may extend between the capless sample well port and the fluid reservoir. The fluid drive port may be in fluid communication with the fluidic channel. The fluid drive port may be configured to be operably connected to a pressure source such that a pressure is applied within the fluidic channel to direct the sample material towards the fluid reservoir. 1. A cartridge comprising:a cartridge body defining a capless sample well port configured to receive a sample material and a fluidic channel in fluid communication with the capless sample well port;a filter positioned between the capless sample well port and the fluidic channel;a fluid reservoir, wherein the fluidic channel extends between the capless sample well port and the fluid reservoir; anda fluid drive port in fluid communication with the fluidic channel, wherein the fluid drive port is configured to be operably connected to a pressure source such that a pressure is applied within the fluidic channel to direct the sample material towards the fluid reservoir.2. The cartridge of claim 1 , wherein the filter defines a bubble point of less than or equal to 4 claim 1 ,000 Pa.3. The cartridge of claim 1 , wherein the fluidic channel is configured to provide a capillary action on the sample material passing through the fluidic channel.4. The cartridge of claim 1 , wherein the capless sample well port is located between the fluid drive port and the fluid reservoir.5. The cartridge of claim 1 , wherein the fluidic channel further comprises an overflow fluidic channel portion claim 1 , wherein the overflow fluidic ...

Test Barrel for Placing Test Paper Card

The present invention provides a test barrel for placing a test paper card. The test barrel comprises a barrel body and a barrel lid; wherein the barrel body comprises a place reminding board arranged on the barrel body; and the barrel lid comprises an elastic piece arranged on the barrel lid and mating with the place reminding board. The test barrel for placing a test paper card according to the present invention is simple in structure and convenient in operation, and greatly reduces time for test. In addition, a place reminding structure is arranged on the test barrel, which facilitates use of the test barrel for the user and achieves sealing reminding. Further, the test result is accurate, the reusage rate is high, and cleaning is convenient. 1. A test barrel for placing a test paper card , characterized in that:{'b': 1', '2, 'claim-text': [{'b': 1', '11', '1, 'wherein the barrel body () comprises a place reminding board () arranged on the barrel body (); and'}, {'b': 2', '21', '2', '11, 'the barrel lid () comprises an elastic piece () arranged on the barrel lid () and mating with the place reminding board ().'}], 'the test barrel comprises a barrel body () and a barrel lid ();'}2. The test barrel for placing a test paper card according to claim 1 , characterized in that:{'b': 1', '12', '12', '2', '13', '3', '13, 'the barrel body () is configured to be a hollow cuboid structure, wherein a top end of the cuboid structure extends perpendicularly upwards to define a cylindrical barrel mouth (), a periphery of the barrel mouth () is provided with threads connecting to the barrel lid (), the cuboid structure is internally provided with a securing member () for securing a test paper card (), and the securing member () is configured to a cylindrical bump.'}3. The test barrel for placing a test paper card according to claim 1 , characterized in that:{'b': 11', '1', '21, 'the place reminding board () is a strip-shaped bump arranged on the barrel body (), wherein a side of ...

Instrument for analytical sample preparation

An instrument for extraction based molecular sample preparation and related processes is disclosed. The instrument includes a thermally conductive pressure resistant heating chamber and a thermally conductive sample cup positioned in the thermally conductive pressure resistant heating chamber for heating liquids and solids together in the thermally conductive sample cup. A liquid delivery inlet fixture in the thermally conductive pressure resistant heating chamber delivers liquids (solvent) from a supply to the thermally conductive sample cup in the thermally conductive pressure resistant heating chamber, and a chiller in liquid communication with the thermally conductive sample cup in the thermally conductive pressure resistant heating chamber receives heated liquids from the thermally conductive pressure resistant heating chamber when the chamber is opened to atmospheric pressure.

Instrument for Analytical Sample Preparation

An instrument for extraction based molecular sample preparation and related processes is disclosed. The instrument includes a thermally conductive pressure resistant heating chamber and a thermally conductive sample cup positioned in the thermally conductive pressure resistant heating chamber for heating liquids and solids together in the thermally conductive sample cup. A liquid delivery inlet fixture in the thermally conductive pressure resistant heating chamber delivers liquids (solvent) from a supply to the thermally conductive sample cup in the thermally conductive pressure resistant heating chamber, and a chiller in liquid communication with the thermally conductive sample cup in the thermally conductive pressure resistant heating chamber receives heated liquids from the thermally conductive pressure resistant heating chamber when the chamber is opened to atmospheric pressure. 1. A combination for solvent extraction comprising:a heated, pressure-sealed reaction chamber;a heat conductive sample cup in said reaction chamber, said reaction vessel including one open filtered end and a mouth opposite said open filtered end;an extraction sample in said sample cup; anda liquid extraction solvent inside said sample cup and outside said sample cup between the exterior of said sample cup and the interior of said reaction chamber.2. A combination according to wherein said reaction chamber is formed of a thermally conductive material.3. A combination according to wherein said opened filtered end is a foraminous floor and a filter media on foraminous floor.4. A combination according to wherein said filter media is selected from the group consisting of filter paper claim 3 , glass fibers claim 3 , quartz fibers claim 3 , nonwoven polymers and combinations thereof.5. A combination according to wherein said extraction sample is selected from the group consisting of soil claim 1 , plastics claim 1 , prepared foods claim 1 , food packaging claim 1 , agricultural products claim ...

System for imaging andmonitoring fluids

The present disclosure concerns a system for imaging and monitoring fluids to identify the presence of objects therein. Objects that are being identified by the system include, for example, microorganisms, particles, bacteria, cells, foreign substances (e.g. bubbles of air in a liquid, substance that may change visual parameters of the main liquid such as color and transparency), etc. Identification of the objects by the system is then may be followed by analysis to conclude the status of the system (e.g. identifying contamination, impurities, etc.)

ADDITIVE CHANNELS

Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip. 1. A microfluidic device comprising i) a microchannel in fluidic communication with ii) an input port and iii) an output port , iv) one or more first additive channels in fluidic communication with at least one microchannel , positioned at or near said input port.2. The microfluidic device of claim 1 , wherein one first additive channel is positioned on one side of said microchannel near said input port.3. The microfluidic device of claim 2 , wherein another first additive channel is positioned on another side of said microchannel near said input port.4. The microfluidic device of claim 1 , wherein said microchannel comprises an active region comprising cells.5. The microfluidic device of claim 1 , further comprising v) one or more second additive channels in fluidic communication with said microchannel claim 1 , positioned at or near said output port.6. The microfluidic device of claim 5 , wherein one second additive channel is positioned on one side of said microchannel near said output port.7. The microfluidic device of claim 5 , wherein another second additive channel is positioned on another side of said microchannel near said output port.8. A system claim 5 , comprising:a) a fluid sample comprising anticoagulant, said fluid sample disposed inb) a microfluidic device comprising i) a microchannel in fluidic communication with ii) an input port and iii) an output port, iv) one or more first additive ...

SUPPORT DEVICE FOR A SAMPLE MATERIAL CONTAINER FOR CENTRIFUGATION

The invention relates to a support device () for supporting a bag () containing material to be centrifuged in a centrifuge receptacle (), said support device () comprising a resiliently elastic panel () which—when bent—will generate a restoring force, said panel () being of a material and a size which will allow it to be bent elastically at least to such an extent that its two ends will contact one another.

SAMPLING DEVICE FOR SAMPLING FROM A SURFACE OF AN INDUSTRIAL VESSEL WITHOUT REQUIRING A PERSON TO DESCEND INTO AN INDUSTRIAL VESSEL, USING A SWAB

Disclosed is a module for sampling from a surface of an industrial vessel without requiring a person to descend into the industrial vessel, using a swab including a stem and a sampling tip, including a swab holder and a conveyor; the swab holder is adapted to receive and secure one end of the swab stem; and the conveyor is configured to set the swab holder in motion on the surface of the vessel. 1. A module for sampling from a surface of an industrial vessel without requiring a person to descend into the industrial vessel using a swab comprising a stem and a sampling tip , comprising a swab holder and a conveyor;the swab holder being adapted to receive and secure one end of the stem of the swab; andthe conveyor being configured to move the swab holder at the surface of the vessel.2. The module according to claim 1 , wherein the conveyor is configured to move the swab holder parallel to the surface.3. The module according to claim 2 , wherein the conveyor is configured to move the swab holder in translational motion along one or two axes parallel to the surface.4. The module according to claim 3 , wherein the conveyor comprises a motor and a transmission assembly for moving the swab holder along a first axis of travel parallel to the surface;the transmission assembly comprising a first annular belt, a second annular belt, a set of four pinions disposed so as to form the corners of a rectangle, and a conveyor bar to which the swab holder is secured and a first end of which is secured to the first annular belt and a second end is secured to the second annular belt so that the conveyor bar is parallel to two opposite sides of the rectangle formed by the set of four pinions;wherein the first belt is disposed so as to surround two pinions on one of the sides of the rectangular perpendicular to the conveyor bar thereby forming two parallel lines, the first end of the conveyor bar being secured to the line the innermost within the rectangle; andwherein the second belt is ...

DISPOSABLE, INTEGRATED MICROFLUIDIC CARTRIDGE AND METHODS OF MAKING AND USING SAME

The disclosed embodiments concern microfluidic cartridges for detecting biological reactions. In some embodiments, the microfluidic cartridges are configured to perform sequencing operations on a nucleic acid sample. In one aspect, a microfluidic cartridge includes a stack of fluidics layers defining channels and valves for processing the nucleic acid sample to be sequenced, and a solid state CMOS biosensor integrated in the stack. The biosensor has an active area configured to detect signals of biological reactions, wherein substantially all of the active area is available for reagent delivery and illumination during operation. In another aspect, a microfluidic cartridge includes: (a) a flow cell including a reaction site area encompassing one or more reaction sites; (b) fluidics channels for delivering reactants to and/or removing reactants from the reaction site area; (c) a biosensor having an active area configured to detect signals of biological reactions in the reaction site area. The reaction site area is proximal to the active area of the biosensor and the reaction site area spans substantially all of the active area of the biosensor. In some embodiments, the fluidics channels do not substantially overlap with the active area of the biosensor. Methods for manufacturing and operating the microfluidic cartridges are also disclosed. 1. A microfluidic cartridge for detecting biological reactions comprising:(a) a flow cell including a reaction site area encompassing one or more reaction sites;(b) fluidics channels for delivering reactants to and/or removing reactants from the reaction site area;(c) a biosensor having an active area configured to detect signals of biological reactions in the reaction site area,whereinthe reaction site area is proximal to the active area of the biosensor,the reaction site area spans substantially all of the active area of the biosensor, andthe fluidics channels do not substantially overlap with the active area of the biosensor.2. ...

PARTICLE SEPARATING AND MEASURING DEVICE, AND PARTICLE SEPARATING AND MEASURING APPARATUS

A particle separating and measuring device of the present disclosure includes: a first flow path device including a post-separation flow outlet through which a first fluid containing specific particles to be separated flows out; and a second flow path device on which the first flow path device is placed and including a first flow inlet through which the first fluid flows in, the first flow path device in which the post-separation flow outlet is arranged in a lower surface is placed on the second flow path device in which the first flow inlet is arranged in an upper surface of a first region, the post-separation flow outlet and the first flow inlet are connected so as to face each other, and a size of an opening of the first flow inlet is larger than a size of an opening of the post-separation flow outlet. 1. A particle separating and measuring device comprising:a first flow path device having a plate-like shape and including a pre-separation flow inlet through which a fluid flows in that contains specific particles to be separated, a main flow path connected to the pre-separation flow inlet, a plurality of branch flow paths each connected to the main flow path, and a post-separation flow outlet through which a first fluid flows out that contains the specific particles that have been separated; anda second flow path device having a plate-like shape and having a first region on which the first flow path device is placed, and a second region that serves as a measurement region for the specific particles, the second flow path device including a first flow inlet through which the first fluid flows in, a second flow inlet through which a second fluid not containing the specific particles flows in, a first flow path connected to the first flow inlet and through which the first fluid passes, and a second flow path connected to the second flow inlet and through which the second fluid passes, wherein the first flow path and the second flow path are arranged in the second ...

Autoplatelet cartridge device

Embodiments of a platelet testing system include an analyzer console device and a blood testing cartridge configured to releasably install into the console device. The cartridge device is configured with one or more measuring chambers and one or more mixing chambers that are fluidically connected within the cartridge device that enable the mixing of saline and a blood sample to a desired dilution. Additionally, the cartridge device is further configured with a cartridge slider that provides a reagent bead to the saline and blood mixture at a desired time. As such, one or more platelet activation assays can be conducted by measuring, through cartridge electrodes of the cartridge device, the detectable changes in platelet activity within the blood and saline mixture.

AUTOPLATELET CARTRIDGE DEVICE

Embodiments of a platelet testing system include an analyzer console device and a blood testing cartridge configured to releasably install into the console device. The cartridge device is configured with one or more measuring chambers and one or more mixing chambers that are fluidically connected within the cartridge device that enable the mixing of saline and a blood sample to a desired dilution. Additionally, the cartridge device is further configured with a cartridge slider that provides a reagent bead to the saline and blood mixture at a desired time. As such, one or more platelet activation assays can be conducted by measuring, through cartridge electrodes of the cartridge device, the detectable changes in platelet activity within the blood and saline mixture. 1. A cartridge device for testing platelet activity in a blood sample comprising: a measuring chamber configured to contain a defined volume of fluid;', 'a mixing chamber in fluid communication with the measuring chamber through a duct that further comprises a valve seat, the mixing chamber further comprising an inlet for receiving a reagent bead; and', 'a cavity located on a top surface of the cartridge body;, 'a cartridge body comprising 'a valve structure configured to couple with the valve seat of the cartridge body and block fluid flow between the measuring chamber and mixing chamber;', 'a left cover coupled to the cartridge body, the left cover comprisinga cartridge slider comprising an opening configured to receive the reagent bead, the cartridge slider located within the cavity of the cartridge body; and an extension structure; and', 'one or more electrode wires coupled to the extension structure, wherein a portion of the one or more electrode wires are situated within the mixing chamber of the cartridge body when the cartridge electrode is coupled with the cartridge body., 'a cartridge electrode configured to couple with the cartridge body, the cartridge electrode comprising2. The cartridge ...

Microfluidic cartridge comprising silicone pressure-sensitive adhesive

A microfluidic cartridge is provided. The microfluidic cartridge has an interior and an exterior. The microfluidic cartridge includes a reservoir disposed in the interior of the microfluidic cartridge and configured to contain a fluid composition. The microfluidic cartridge includes an electric circuit disposed on the exterior of the microfluidic cartridge. The electric circuit comprises a first end portion having electrical contacts and a second end portion opposing the first end portion. The microfluidic cartridge includes a microfluidic die disposed on the exterior of the microfluidic cartridge, wherein the microfluidic die is electrically connected with the second end portion of the electric circuit and in fluid communication with the reservoir. A silicone pressure-sensitive adhesive is used to join the electric circuit with the exterior of the microfluidic cartridge.

3D PRINTED OPTOFLUIDIC DEVICE AND METHODS OF FABRICATION

Methods and systems for optofluidic device fabrication and design are herein disclosed. In examples, a user may manufacture the optofluidic device using stereolithography (SLA) three-dimensional (3D) printing, in which photosensitive resin is exposed to a focused laser, solidifying specific areas of resin. The optofluidic device may guide light for a broad wavelength range from a liquid or gas channel comprised within and may be used to guide the emission of light and particles of interest to a detector to identify the particles. 1. A method of manufacturing an optofluidic device , comprising:lowering a build platform into a vat of undeveloped resin;causing a light source to emit a light in a first pattern on the undeveloped resin such that a first layer of resin is deposited on the build platform, the first layer of resin being developed resin;causing the light source to emit light in a second pattern such that a second layer of resin is deposited on the first layer of resin, a first portion and a second portion of the second layer of resin being developed and a third portion of the second layer of resin remaining undeveloped, the third portion of the second layer of resin deposited between the first portion and second portion;causing the light source to emit light in a third pattern such that a third layer of resin is deposited on the second layer of resin, the third layer of resin including a first portion, a second portion, and a third portion that is developed resin, the third layer of resin including a fourth portion and a fifth portion remaining undeveloped, the fourth portion of the third layer of resin deposited between the first portion and second portion of the third layer of resin, and the fifth portion of the third layer of resin deposited between the second portion and third portion of the third layer of resin;causing the light source to emit light in a fourth pattern such that a fourth layer of resin is deposited on the third layer of resin, the ...

MICROFLUIDIC CHIP AND REAL-TIME ANALYSIS DEVICE USING SAME

The present invention relates to a microfluidic chip and a real-time analysis device using same, and more specifically, to a microfluidic chip and a real-time analysis device using same capable of securing reliability of measurement results by appropriately preventing reduction of optical signal sensitivity due to bubbles included in a fluid. According to one embodiment of the present invention, the microfluidic chip is provided. The microfluidic chip comprises: at least one reaction chamber which comprises at least one optical measuring area, and in which a random reaction of a fluid received therein takes place; and a bubble eliminating portion comprising a light transmitting material which protrudes from an the inner surface of an upper part of the microfluidic chip toward the inside of the reaction chamber, to prevent bubbles included in the fluid from being included in the optical measuring area. 19-. (canceled)10. A microfluidic chip comprising:an upper part;a bottom part; andat least one reaction chamber situated between the upper part and the bottom part, the reaction chamber intended to hold a fluid and having an optical measuring area; and the upper part comprises a bubble-eliminating portion made of a light-transmitting material, and', 'the bubble-eliminating portion protrudes toward the interior of the reaction chamber and is intended to prevent bubbles in said fluid from residing in the optical measuring area of the reaction chamber., 'wherein11. The microfluidic chip according to claim 10 , wherein the bubble-eliminating portion is located in an optical path between a light-emitting module and a light-detecting module for detecting optical signals in said fluid.12. The microfluidic chip according to claim 10 , wherein the microfluidic chip is partially made of a light-transmitting material.13. The microfluidic chip according to claim 12 , wherein the optical measuring area is at or near the center of the reaction chamber and is made of a light- ...

INSTRUMENT FOR PERFORMING A DIAGNOSTIC TEST ON A FLUIDIC CARTRIDGE

Instrument for performing a diagnostic test on a fluidic cartridge A cartridge reader is for carrying out a diagnostic test on a sample contained in a fluidic cartridge inserted into the reader. The fluidic cartridge comprises a fluidic layer comprising at least one sample processing region, at least one collapsible blister containing a liquid reagent, a pneumatic interface, an electrical interface and at least one mechanical valve. The reader comprises a housing; an upper clamp occupying a fixed position relative to the reader, and a lower clamp, movable relative to the first clamp, wherein the upper clamp and the lower clamp define a cartridge receiving region therebetween. The reader comprises a thermal module comprised in the lower clamp, wherein the thermal module comprises at least one thermal stack for heating the at least one sample processing region of the cartridge inserted into the reader. The reader comprises at least one mechanical actuator for actuating the mechanical valve comprised in the cartridge inserted into the reader. 1. A cartridge reader for carrying out a diagnostic test on a sample contained in a fluidic cartridge inserted into the reader , wherein the fluidic cartridge comprises a fluidic layer comprising at least one sample processing region , at least one collapsible blister containing a liquid reagent , a pneumatic interface , an electrical interface and at least one mechanical valve , wherein the reader comprises:a housing;an upper clamp occupying a fixed position relative to the reader, and a lower clamp, movable relative to the first clamp, wherein the upper clamp and the lower clamp define a cartridge receiving region therebetween;a thermal module comprised in the lower clamp, wherein the thermal module comprises at least one thermal stack for heating the at least one sample processing region of the cartridge inserted into the reader;a pneumatics module comprising a plurality of pneumatic interface ports for coupling to the ...

System for Rapid, Portable, and Multiplexed Detection and Identification of Pathogen Specific Nucleic Acid Sequences

A sample carrier may include a sample preparation module and an amplification module. A sample mixes with a lysis medium and a nucleic acid amplification medium in the sample preparation module and then flows into a plurality of microfluidic chambers in the amplification module. The microfluidic chambers have disposed therein primers configured to initiate amplification of one or more target nucleic acid sequences corresponding to one or more pathogens. The sample carrier is inserted into an apparatus that includes a plurality of Sight sources and a camera. The light sources illuminate the microfluidic chambers with excitation light, a fluorophore emits fluorescence light indicative of nucleic acid amplification in response to the excitation-light, and the camera captures images of the microfluidic chambers. A target nucleic acid sequence in the sample is indicated by the images showing an increasing fluorescence in a microfluidic chamber that has the primers for that sequence. 1. An apparatus for optically interrogating a sample in a sample carrier , the sample carrier comprising a plurality of microfluidic chambers , each of the microfluidic chambers containing a respective portion of the sample mixed with a nucleic acid amplification medium , the apparatus comprising:a housing, wherein the housing has an interior space and a slot through which the interior space is accessible, wherein the slot is configured to receive the sample carrier such that the microfluidic chambers are disposed at a working position within the interior space;a plurality of light sources coupled to the housing, wherein each of the light sources is configured to illuminate the microfluidic chambers disposed at the working position with excitation light, wherein a fluorophore in the nucleic acid amplification medium is configured to emit fluorescence light indicative of nucleic acid amplification in response to the excitation light; anda camera coupled to the housing, wherein the camera is ...

OPTOFLUIDIC DIAGNOSTICS SYSTEM

An optofluidic diagnostic system and methods for rapid analyte detections. The system comprises an optofluidic sensor array, a test plate and an optical detection cartridge. The sensor array supports one or more distinct sensor units, each having a reactor section designed to temporarily enter a series of different kinds of wells in the test plate. One kind of well is a sample reservoir that holds reagent solution to be transferred into the reactor section. Another kind of well is a drainage chamber that removes reagent solution from the reactor section. A third kind of well is a colorant reservoir that holds a colorant reagent transferable into a reactor section. Finally, the sensor unit is transferred to the optical detection cartridge where it is placed into an isolation booth during the optical detection process so that its flat observation face is stationed in a viewing window opposite an optical detector lens. 1. A multi-well test plate for an optofluidic diagnostic system configured to interact with at least one sensor unit moved sequentially into and out of registry therewith , said test plate comprising:a plurality of wells, each said well having a well depth defined by an upper mouth and a lower base, each said well in said plate having a generally equal well depth,at least three wells being arranged in a sequence cluster, at least one well in said sequence cluster comprising a sample reservoir containing a liquid analyte reagent, at least one well in said sequence cluster comprising a drainage chamber configured to drain liquid reagents from a sensor unit, and at least one well in said sequence cluster comprising a colorant reservoir containing a liquid color development reagent.2. The test plate of claim 1 , wherein said sequence cluster includes a plurality of said sample reservoirs and a corresponding plurality of said drainage chambers claim 1 , said plurality of sample reservoirs disposed in alternating fashion with said plurality of drainage ...

DETECTION DEVICE AND DETECTION SYSTEM

A detection device includes a rectangular tube, an alignment film, a probe, and a nematic liquid crystal (LC). The rectangular tube has a tube wall and a receiving space located inside the tube wall. The tube wall has one or more light-transmittable region. The alignment film is located on the tube wall and corresponds to the light-transmittable region. The probe is distributed on the alignment film. The nematic LC is located in the receiving space. The probe includes an antibody, an antigen, or both the antibody and the antigen. Furthermore, a detection system is also provided. 1. A detection device , comprising:a rectangular tube having a tube wall and a receiving space located in the tube wall, wherein the tube wall has at least one light-transmittable region, the rectangular tube comprises two first plates disposed opposite to each other and two second plates disposed opposite to each other, two sides of each first plate are connected to the two second plates, two sides of each second plate are connected to the two first plates, a distance between the two first plates is a tube height of the rectangular tube, and the at least one light-transmittable region is located on each first plate;an alignment film located on the tube wall and corresponding to the at least one light-transmittable region;a probe distributed on the alignment film; anda nematic liquid crystal (LC) located in the receiving space;wherein the probe comprises at least one selected from a group consisting of an antibody and an antigen.2. The detection device according to claim 1 , wherein the probe has a concentration of 10 μg/mL to 20 μg/mL.3. The detection device according to claim 1 , wherein the probe is a protein.4. The detection device according to claim 1 , wherein a ratio of a tube width to the tube height of the rectangular tube ranges from 10 to 20.5. The detection device according to claim 1 , wherein the at least one light-transmittable region is located at one end of each first plate. ...

Optical Cup

The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light, an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.

RESERVOIR ASSEMBLY AND METHOD OF USE

A reservoir assembly having one or more troughs mounted within a reservoir frame by interconnecting the one or more troughs to a reservoir frame, which is SBS-compliant in some embodiments. In some embodiments, each of the one or more troughs provides both mounting projections and projection mounting channels, and the reservoir frame provides a plurality of projection mounting channels or mounting projections. In embodiments having multiple such troughs, the troughs can be interconnected, and mounted to the reservoir frame, via mounting projections penetrating mating mounting channels. The reservoir assembly can include one or more troughs or other components having a wide variety of shapes and sizes. One or more components in the reservoir assembly may be opaque, and troughs may be stored and moved in an interconnected fashion, stabilizing the troughs and reducing spilling or splashing of contents. 1. A reservoir assembly comprising in combination:A. at least one trough having a rectangular outer periphery and at least one mounting tab extending from the rectangular outer periphery;B. a reservoir frame having a rectangular interior trough mounting passage and at least one mounting tab channel penetrating the rectangular interior trough mounting passage.2. A reservoir assembly of comprising in combination:A. a plurality of troughs each having a rectangular outer periphery and at least one mounting tab extending from the rectangular outer periphery;B. an SBS compatible reservoir frame having a rectangular interior trough mounting passage and a plurality of mounting tab channels penetrating the rectangular interior trough mounting passage.3. The reservoir assembly of wherein at least two among the plurality of troughs have substantially differing configurations.4. The reservoir assembly of wherein the one trough also has a mounting tab channel penetrating the rectangular outer periphery.5. The reservoir assembly of wherein the plurality of troughs each also have a ...

AN ELECTROCHEMICAL SENSOR ARRAY AND APPARATUS

This invention relates to an apparatus suitable to be used for analyzing at least one sample with an electrochemical sensor array, comprising at least one upper layer; at least one inlet and at least one outlet opening provided on the upper layer; at least one lower layer having at least one recess thereon; at least one two-sided adhesive membrane matching to the recess; at least one sensor array secured to the lower layer, at least one reference electrode, at least one counter electrode, at least one communication channel, at least one conductive line providing a connection between the working electrode and the communication channel on at least one plate; at least one further two-sided adhesive membrane spaced from the adhesive membrane positioned on the lower layer and enabling the sensor array to be secured to the upper layer. 1. An apparatus suitable to be used for analyzing at least one sample with an electrochemical sensor array comprising:at least one upper layer;at least one inlet and at least one outlet opening provided on the upper layer and whereinat least one lower layer having at least one recess thereon;at least one two-sided adhesive membrane matching to the recess on the lower layer;at least one sensor array secured to the lower layer by means of the adhesive membrane composed of positioning at least one working electrode, at least one reference electrode, at least one counter electrode, at least one communication channel, at least one conductive line providing a connection between the working electrode and the communication channel, on at least one plate;at least one measuring device associated with the communication channel;at least one further two-sided adhesive membrane spaced from the adhesive membrane positioned on the lower layer and enabling the sensor array to be secured to the upper layer, andat least one flow channel formed as a result of the space between the adhesive membranes and associated with the inlet and outlet openings located on ...

METHODS FOR FABRICATING MORPHOLOGICALLY TRANSFORMED NANO-STRUCTURES (MTNS) AND TUNABLE NANOCOMPOSITE POLYMER MATERIALS, AND DEVICES USING SUCH MATERIALS

In order to implement a microfluidics sensor having higher efficiency, Applicants have developed a method of formation of nano-structures having various shapes and sizes onto materials such as polymers, glass and silicon, which are compatible with the microfabrication processes. The adhesion of the nano-structures and feasibility to tune their properties (optical, electrical and mechanical) are two prime concerns when they are adopted for microfluidics devices. 1. A method of fabrication of nanoparticle reinforced polymer comprising:performing a partial and controlled reduction of metal salts to metal nanoparticles by using a crosslinking or curing agent during the preparation process of the polymer; andadding electrically conductive nanoparticles to the polymer during the preparation process.2. The method of wherein performing a partial and controlled reduction of metal salts comprises controlling the reduction by varying the concentration of the metal salts and the crosslinking agent.3. The method of claim 1 , wherein performing a partial and controlled reduction of metal salts to nanoparticles comprises:tuning at least one of optical, electrical, mechanical, thermal and chemical properties of the polymer for various applications by controlling the percentage weight (wt %) of the nanoparticles in the polymer by adjusting an amount of crosslinking agent and a concentration of the metal salts during preparation of polymer.4. (canceled)5. The method of wherein subsequent to adding electrically conductive nanoparticles to the polymer claim 1 , the method further comprises mechanically stimulating the polymer to mix the electrically conductive nanoparticles of same or different shapes and sizes uniformly in the polymer.6. (canceled)7. The method of wherein the polymer is one of:Polydimethylsiloxane (PDMS); Poly(methyl methacrylate) (PMMA); Polyurethane (PUR and PU); Polystyrene (PS); Ethylene Copolymer; Cyclo Olefinecopolymer; Cyclic Olefin Polymer (COC); Ethylene- ...

BIOSAMPLE PLATE WITH DATA STORAGE AND WIRELESS COMMUNICATIONS

Embodiments of the disclosure relate to a biosample plate that includes a memory component for storing biosample identification and analysis data, and a wireless communication interface for transferring the data to and from the biosample plate. In one embodiment, the biosample plate comprises a base for receiving a biosample, a memory component coupled to the base for storing identification and analysis information related to the biosample, and a wireless communication interface coupled to the memory component for transferring the information to and from the memory component. The wireless communication interface may include an electromagnetic device. 1. A biosample plate comprising:a base for receiving a biosample;a memory component coupled to the base for storing identification and analysis information related to the biosample; anda wireless communication interface coupled to the memory component for transferring the information to and from the memory component,wherein the wireless communication interface includes an electromagnetic device.2. The biosample plate of claim 1 , wherein the wireless communication interface also uses radio signals for communication.3. The biosample plate of claim 2 , wherein the wireless communication interface is formed by a plurality of metal-plated trenches disposed in the base.4. The biosample plate of claim 3 , further comprising a plurality of parallel side walls disposed on the base to form the metal-plated trenches.5. The biosample plate of claim 3 , wherein the metal is selected from the group consisting of gold claim 3 , silver claim 3 , copper and platinum claim 3 , and the biosample comprises antigens that are attached to the metal-plated trenches through antibodies.6. The biosample plate of claim 1 , wherein the communication interface also includes an optical device.7. The biosample plate of claim 1 , wherein the memory component comprises a nonvolatile memory disposed on the base.8. The biosample plate of claim 7 , ...

CRYOGENIC STORAGE BOX

An apparatus having a cryogenic storage box able to withstand temperatures down to at least negative (−)180 degrees Celsius. The cryogenic storage box includes a lid member coupled to a base member via a hinge. The lid member includes slots and magnets held therein via pressure. The base member also includes slots having magnets held therein via pressure, as well as vial supports configured to support vials in an upright position. When the lid member is in a closed position, each lid magnetic aligns with a base magnet along a respective vertical axis to magnetically couple the lid member to the base member. 2. The apparatus of claim 1 , wherein the first and second lid magnets and the first and second base magnets are positioned on an inner portion of the cryogenic storage box.3. The apparatus of claim 2 , wherein the first lid magnet and the second lid magnet are positioned at a first corner of the box and the second lid magnet and the second base magnet are positioned at a second corner of the cryogenic storage box claim 2 , each of the corners spaced away from the hinge.4. The apparatus of claim 1 , wherein the base member comprises:an upper unit having the plurality of vial supports, wherein the upper unit includes the first and second base magnets; anda lower unit coupled to the upper unit.5. The apparatus of claim 2 , wherein the lid member and the base member each have a plurality of vent openings configured to allow the passage of air through the cryogenic storage box when in a closed configuration.6. The apparatus of further comprising a plurality of offsets that protrude from a bottom surface of the base member.7. The apparatus of claim 6 , wherein the plurality of offsets are configured to set into a plurality of vent openings of a second cryogenic storage box when placed on the second cryogenic storage box.8. A cryogenic storage box configured to store vials in low temperatures claim 6 , the cryogenic storage box comprises:a lid member;a base member ...

METHOD AND SYSTEM FOR CLASSIFYING SAMPLE DATA FOR ROBOTICALLY EXTRACTED SAMPLES

A method of classifying sample data for robotically extracted samples is disclosed. A specimen is received from a human subject with a potential infection of a first disease agents or a plurality of disease agents. The specimen includes genetic material collected from a human subject using a collection device and stored in a collection carrier. The specimen includes a unique identifier on the collection carrier. The unique identifier contains human subject descriptive data. The method classifies the human subject descriptive data to identify a second disease agent. The method extracts a sequence of genetic material from the specimen using an automated robot. The method determines a test result for the first disease agent as a function of the sequence of genetic material. A system comprising a computer device configured to classify sample data for robotically extracted samples is also disclosed. 1. A method of classifying sample data for robotically extracted samples , the method comprising:{'claim-text': ['genetic material collected from the human subject using a collection device and stored in a collection carrier; and', 'a unique identifier on the collection carrier;'], '#text': 'receiving data related to a specimen from a human subject with a potential infection of a first disease agent, wherein the specimen comprises:'}retrieving, by a computing device, human subject descriptive data from an optical scanning device as a function of the unique identifier;{'claim-text': ['generating a classifier using a first machine-learning process as a function of human subject descriptive training data, wherein the human subject descriptive training data correlates human subject descriptive data with a second disease agent; and', 'generating the identity of the second disease agent as a function of the descriptive data and the classifier;'], '#text': 'classifying, at the computing device, the human subject descriptive data to identify a second disease agent, wherein ...

SINGLE CHANNEL CARTRIDGE DEVICE FOR COAGULATION ASSAYS IN FLUID SAMPLES

The present invention relates to analytical testing devices comprising a single channel with micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using a single channel with micro-environment sensors in a point of care test cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample and a conduit fluidically connected to the inlet chamber. The conduit includes a sensor chip including a first micro-environment sensor and a second microenvironment sensor, and a fluid lock valve. The sample analysis cartridge further includes a pump configured to push the biological sample over the first micro-environment sensor and the second microenvironment sensor to the fluidic lock valve such that the biological sample is positioned over the first micro-environment sensor and the second micro-environment sensor. 1. A method of analyzing a biological sample within a sample analysis cartridge , the method comprising:receiving a biological sample in an inlet chamber of the sample analysis cartridge;moving, using a pump, the biological sample from the inlet chamber to a conduit of the sample analysis cartridge; andpushing, using the pump, the biological sample in the conduit to a fluidic lock valve, such that at least a portion of the biological sample is positioned in the conduit over a portion of a sensor chip comprising a first micro-environment sensor and a second micro-environment sensor, each of the first micro-environment sensor and the second micro-environment sensor comprising at least one transducer coated with a polymer layer,wherein the conduit comprises a first reagent integrated within, coated over, positioned adjacent, or a combination thereof to the polymer layer of the first micro-environment sensor, and a second reagent integrated within, coated ...

COAGULATION AND AGGREGATION REFRACTED LIGHT INDEXING DEVICE AND METHOD

The present invention related to a device suitable for measuring an alteration of the state of a sample, comprising: a housing having a hollow interior, a light source positioned within the interior of the housing, a sensor positioned within the hollow interior of the chamber, wherein the sensor is able to measure the light of the interior of the housing, and a computing system connected to the light source and the sensor. 1. A device suitable for measuring an alteration of the state of a sample , comprising:a housing having a hollow interior;a light source positioned within the interior of the housing;a sensor positioned within the hollow interior of the housing; anda computing system connected to the light source and the sensor.2. The device of claim 1 , wherein a first portion of a surface of the hollow interior of the housing claim 1 , wherein the first portion of the surface has a reflective layer.3. The device of claim 1 , wherein a second portion of the surface of the hollow interior of the housing claim 1 , wherein the first portion of the surface has a low reflective coating.4. The device of claim 3 , wherein the light source is directed at the low reflective coating.5. The device of claim 1 , further comprising:a sample cartridge receiver positioned within the housing and between the light source and the sensor.6. The device of claim 1 , further comprising:a cover attached to the housing, wherein the cover is removable to allow access to the interior of the housing.7. The device of claim 1 , further comprising:an opening accessible from the exterior of the housing, wherein the opening is sized to accept a specimen.8. The device of claim 7 , further comprising:a set of guide rails, wherein the guide rails are sized and positioned to receive the specimen.9. The device of claim 1 , further comprising:a set of guide rails, wherein the guide rails are sized and positioned to receive the specimen and are accessible with the cover removed.10. The device of claim ...

MULTISTEP REACTION LATERAL FLOW CAPILLARY DEVICE

Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs. During use of the disclosed lateral flow capillary device a static interface is formed between the first liquid and the second liquid in an interface creation zone inside the capillary flow matrix wherein the first amount and second amount are such that first liquid substantially remains in the first reservoir and the second liquid substantially remains in the second reservoir subsequent to the formation of the static interface and wherein the interface begins to move only subsequent to exhaustion of a liquid from a reservoir. 2. The device of claim 1 , wherein said pressing is such that liquid induced swelling of said matrix is constrained.3. The device of claim 1 , wherein said rims press said matrix when said matrix is dry.4. The device of claim 1 , wherein said rims are pressed into said matrix when said matrix is dry.5. The device of claim 1 , wherein said rims are substantially parallel to said flow direction.6. The device of claim 1 , wherein pressure applied by a said rim is substantially uniform about the entire surface of said rim.7. The device of claim 1 , said matrix being substantially compressible.8. The device of claim 1 , said matrix comprising glass fibers.9. The device of claim 8 , said matrix consisting essentially of glass-fibers.10. The device of claim 1 , wherein the internal surface-area volumeof said matrix proximate to a said rim is higher than distant from said rim.11. The device of claim 1 , wherein opposite each said rim is ...

LIQUID DELIVERY METHOD, AND DETECTION SYSTEM AND DETECTION APPARATUS FOR IMPLEMENTATION OF THIS METHOD

Aiming to provide a method capable of reciprocatingly delivering various liquids without bringing air into a microchannel, a detection system and a detection apparatus for implementation of this method. In order to achieve at least one of the above aims, provided is a method of inserting a pipette tip into a liquid injection portion of a detection chip including: the microchannel; the liquid injection portion connected to one end of the microchannel; and a reservoir connected to the other end of the microchannel, injecting and aspirating the liquid by the pipette tip, and reciprocatingly delivering the liquid into the microchannel. At this time, the following steps are executed in this order, the steps including: inserting the pipette tip into the liquid injection portion up to a position at which an end of the pipette tip comes below a liquid level when the liquid is injected into the liquid injection portion; injecting the liquid from the pipette tip into the liquid injection portion; generating a negative pressure in the liquid injection portion to raise the level of the liquid in the liquid injection portion; and performing either aspiration of the liquid in the liquid injection portion by the pipette tip, or injection of the liquid into the liquid injection portion by the pipette tip and aspiration of the liquid inside the liquid injection portion. 1. A liquid delivery method of first inserting a pipette tip into a liquid injection portion of a detection chip including: a microchannel; the liquid injection portion connected to one end of the microchannel for injecting a liquid; and a reservoir connected to the other end of the microchannel for temporarily storing the liquid , the insertion being performed to achieve a hermetically sealed state of the liquid injection portion , then injecting and aspirating the liquid by the pipette tip to reciprocatingly deliver the liquid into the microchannel ,the method comprising executing, in this order:inserting the ...

MICROFLUIDIC DEVICE AND A METHOD OF LOADING FLUID THEREIN

A microfluidic AM-EWOD device and a method of filling such a device are provided. The device comprises a chamber having one or more inlet ports. The device is configured, when the chamber contains a metered volume of a filler fluid that partially fills the chamber, preferentially maintain the metered volume of the filler fluid in a part of the chamber. The device is configured to allow displacement of some of the filler fluid from the part of the chamber when a volume of an assay fluid introduced into one of the one or more inlet ports enters the part of the chamber, thereby causing a volume of a venting fluid to vent from the chamber. 1. A method of loading an electro-wetting on dielectric (EWOD) device with an assay fluid , the EWOD device comprisinga) first and second substrates spaced from one another to define a chamber therebetween;b) at least one inlet port, configured for inputting assay and/or filler fluid into the chamber; and the method comprising:', 'introducing, into the chamber of the EWOD device via-one or more of the at least one inlet ports, a metered volume of a filler fluid such that the chamber is partially filled with the filler fluid, the chamber containing a venting fluid, said device being configured to preferentially maintain the metered volume of the filler fluid in a part of the chamber; and', 'introducing a volume of the assay fluid into the part of the chamber via one of the one or more inlet ports and thereby causing a volume of the venting fluid to vent from the chamber., 'c) at least one output port, configured for venting from the chamber;'}2. A method of loading a microfluidic device with an assay fluid , the method comprising:substantially completely filling a chamber with a filler fluid or with a fluid mixture containing a filler fluid as one component, the chamber having one or more inlet ports and an outlet port for extracting the filler fluid;inserting a volume of the assay fluid into one of the one or more inlet ports; ...

SYSTEMS AND METHODS FOR HIGH THROUGHPUT SCREENING

Provided herein are compositions, systems, and methods for high throughput screening. In particular, provided herein are microfluidic devices for high throughput analysis of multiplex chemical (e.g., drug interactions) across a wide range of concentrations. 1. A microfluidic device , comprising:i) a routing layer comprising a plurality of microfluidic channels and a plurality of chemical reservoirs, wherein said microfluidic channel are in fluid communication with said chemical reservoirs;ii) a mixing layer comprising a plurality of biased tree mixers comprising microchannels of a plurality of different widths patterned therein and a plurality of sphere culture chambers; andiii) a lid layer comprising a plurality of chemical inlet holes, a plurality of cell inlet holes, and a plurality of vias.2. The device of claim 1 , wherein said vias are microfluidic channels claim 1 , punched holes claim 1 , or tubing that connect said lid claim 1 , said mixing layer claim 1 , and said routing layer.3. The device of claim 1 , wherein said routing layer forms the bottom layer of said device claim 1 , said mixing layer forms the middle layer of said device claim 1 , and said lid layer forms the top layer of said device.4. The device of claim 1 , wherein said microfluidic channels are 100 to 1000 μm in width and 100 to 1000 μm in height.5. The device of claim 4 , wherein said microfluidic channels are approximately 800 μm in width and 300 μm in height.6. The device of claim 1 , wherein sphere culture chambers are coated in a polyethylene glycol blocking agent.7. The device of claim 1 , wherein said mixing layer in configured to generate all possible drug combinations with a plurality of different mixing ratios of said chemicals for a plurality of different chemicals.8. The device of claim 7 , wherein said device is configured to generate at least 3 different mixing ratios of said chemicals.9. The device of claim 7 , wherein said device is configured to generate at least 5 ...

Coplanar microfluidic manipulation

An apparatus includes a polymer base layer having a surface. A die that includes a fluid manipulation surface that is substantially coplanar with the surface of the polymer base layer. The die includes a control electrode to generate an electric field to perform microfluidic manipulation of fluid across the fluid manipulation surface of the die.

Systems and methods for facilitating fluid flow during enhanced detection and quantification of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Cartridges, collectors, kits, and methods for enhanced detection and quantification of analytes in collected fluid samples

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

LABORATORY SPECIMEN TRAY

A laboratory specimen tray for the organization of medical and scientific specimens for improving continuity of case/patient identification and reduction in the mislabeling or mixing of specimens between patients is provided. The specimen tray may be an elongated body of material that forms various voids for securing various types of specimen containers and associated paperwork. An upper surface of the specimen tray provides a distinct demarcation, such as one of a plurality of colors, so that two specimens of the same type are never next to each other in a laboratory setting, further preventing the possibility of specimen/patient mix ups. This separation makes sure that a cassette during sectioning by the technologist is not accidentally cut and placed on the wrong patient slide. 1. A laboratory specimen tray device , comprising:an elongated body of material having opposing lower and upper surfaces;an elongated slot formed along the upper surface so as to extend substantially the full length thereof;a plurality of circular recesses formed along the upper surface;a plurality of rectangular cavities formed along the upper surface, each circular recess operatively aligns with one of the plurality of rectangular cavities, and wherein each rectangular cavity is dimensioned to accommodate a square tissue cassette; andan identification marking is provided along the upper surface.2. The device of claim 1 , wherein the upper surface is not coextensive with the lower surface claim 1 , forming an overhanging flange on each of the opposing ends of the elongated body.3. The device of claim 1 , wherein the identification marking is a color.4. The device of claim 1 , wherein each circular recess comprises at least one gripping circular recess claim 1 , wherein each gripping circular recess provides a circumferential grip insert extending into said gripping circular recess.5. (canceled)6. The device of claim 1 , wherein the plurality of circular recesses are aligned with each ...

DIAGNOSTIC SYSTEM

Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test. 1. A method of testing a sample suspected of containing one or more target pathogens , comprising:accepting a cartridge having a sample port assembly containing the sample suspected of containing the one or more target pathogens;advancing the sample suspected of containing the one or more target pathogens to a lysis chamber within the cartridge having at least one lysis reagent therein;mixing the sample with the at least one lysis agent to generate a lysed sample;passing the lysed sample through a first porous solid support within the cartridge to capture a nucleic acid on the porous solid support;releasing the captured nucleic acid from the first porous solid support to generate an enriched nucleic acid;introducing the enriched nucleic acid into a rehydration chamber within the cartridge containing one or more dried reagents;after introducing the enriched nucleic acid into a metering channel, mixing the contents of the rehydration chamber to produce an analyte/reagent solution;distributing the analyte/reagent solution to two or more assay chambers within the cartridge;combining the analyte/reagent solution with one or more amplification reagents after performing the distributing step;sealing each one of the two or more assay chambers within the cartridge containing analyte/reagent solution from each one of all the other two or more assay chambers within the cartridge containing analyte/reagent solution ...

Lateral flow device, assay device and kit and method for analyzing a fluid sample

The invention concerns a lateral flow device, system, kit and method for analyzing a fluid sample. The device comprises a support structure, a flow channel formed in the support structure, and an injection zone in fluidic connection with the flow channel for introducing the fluid sample into the flow channel. According to the invention the flow channel comprises at least two indicator zones at least one of which is capable of producing an optically detectable response signal when interacting with the fluid sample, and the indicator zones are arranged at least partly adjacent to each other on different sections of the flow channel. The invention allows for low-cost imaging devices, such as cameras of mobile phones to be used for making challenging lateral flow diagnostics on a variety of fields of technology.

Molecule Detecting System

An object is to stably, continuously and easily detect reactions of filamentary biomolecules or polymers bridging between a pair of electrodes against reagents without employing any marker or labeling substances. A molecule detecting system for detecting a reaction of a molecule captured between electrodes to a reagent in a liquid , the system comprising: a detection device including a couple of electrodes and being capable of measuring a resonance frequency and an amplitude of the electrodes; a microfluidic device including a microfluidic channel which includes a channel opening on its one side, wherein an air-liquid interface the electrodes can pass through is formed in the channel opening ; a pressure controlled microfluidic pump connected to an outlet of the microfluidic channel ; a movable holding device movably holding the detection device or the microfluidic device ; and a controller controlling the detection device, the pressure controlled microfluidic pump , and the movable holding device. 1. A molecule detecting system for detecting a reaction of a molecule captured between electrodes to a reagent in a liquid , the system comprising:(a) a detection device including a couple of electrodes and being capable of measuring a resonance frequency and an amplitude of the electrodes;(b) a microfluidic device including a microfluidic channel which includes a channel opening on its one side, wherein an air-liquid interface the electrodes can pass through is formed in the channel opening;(c) a pressure controlled microfluidic pump connected to an outlet of the microfluidic channel;(d) a movable holding device movably holding the detection device or the microfluidic device; and(e) a controller controlling the detection device, the pressure controlled microfluidic pump, and the movable holding device.2. The molecule detecting system according to claim 1 , wherein the detection device is capable of varying a distance between the electrodes at a predetermined frequency.3. ...

Device for Collecting, Transferring, and Storing Samples of a Biological and/or Chemical Material

A device for collecting, transferring, and storing samples of a biological and/or chemical material, wherein the device comprises: a support body, developing along a main longitudinal direction between a first end and a second end opposite to each other and connected by an intermediate portion elongate in the main longitudinal direction, a collection portion engaging the first end and configured to collect a quantity of a sample of a biological and/or chemical material, the collection portion being defined at least by a first coating layer realized on the first end and made from an elastically deformable material and by a second coating layer consisting of a layer of flocked fibers, the second coating layer being realized through a fiber flocking process on the first coating layer and being configured to absorb a quantity of liquid including at least one sample of a biological and/or chemical material.

BIOLOGICAL SPECIMEN HANDLING APPARATUS

In one aspect, a cassette for handling a biological specimen is provided including a compartment having a bottom wall, a front wall, a rear wall, and a pair of side walls. The compartment includes at least one curved juncture connecting the bottom wall and one of the front, rear, and side walls. The at least one curved juncture curves upwardly away from the bottom wall with a curvature that matches a portion of an Archimedean spiral. In another aspect, an apparatus is provided that includes a cassette and a metallic base mold including an upper cavity for receiving the cassette. The metallic base mold includes a cam member configured to direct the cassette downward into the upper cavity as user urges the cassette against the cam member. 1. A generally rectangular cassette for handling a biological specimen , the cassette comprising:a biological specimen-receiving compartment including a bottom wall, a front wall, a rear wall, and a pair of side walls, wherein the front wall, rear wall, and side walls extend obliquely to the bottom wall;at least one curved juncture of the compartment connecting the bottom wall and one of the front wall, rear wall, and side walls; andthe at least one curved juncture curving upwardly away from the bottom wall with a curvature that matches a portion of an Archimedean spiral.2. The cassette of wherein the at least one curved juncture curves upwardly away from the bottom wall with a curvature that continuously increases as the juncture curves away from the bottom wall.3. The cassette of wherein the bottom wall has a periphery and the at least one curved juncture curves upwardly away from the periphery of the bottom wall with a curvature that matches a portion of an Archimedean spiral described in polar coordinates by the equation R=b×θ claim 1 , wherein b is a real number.4. The cassette of wherein the at least one curved juncture includes at least four curved junctures claim 1 , the at least four curved junctures each connecting the ...

COLLECTOR ARCHITECTURE LAYOUT DESIGN

The disclosure provides for compositions and methods for the collection of rare cells using an interspersed microstructure design. 1. A microfluidic channel comprising:a plurality of microstructures within the channel; anda plurality of vortex regions at which one or more vortexes are generated in response to fluid flow, wherein each vortex region is substantially free of the plurality of microstructures and comprises at least a cylindrical volume having (1) a height of the channel and (2) a base having a diameter at least 20% a width of the channel.2. The channel of claim 1 , wherein each vortex region comprises at least a rectangular volume having (1) a height of the channel claim 1 , (2) a width equal to the diameter claim 1 , and (3) a length at least 30% a width of the channel.3. The channel of claim 1 , wherein the plurality of vortex regions are positioned in a palindromic pattern along a length of the channel.4. The channel of claim 1 , wherein the plurality of vortex regions are positioned in a repeating pattern along a length of the channel.5. The channel of claim 1 , wherein the plurality of microstructures are arranged in a plurality of columns substantially parallel to one another and wherein each column of the plurality of columns comprises a column length equal to a distance from an outermost edge of a first microstructure to an outermost edge of a last microstructure in the column.6. The channel of claim 5 , wherein the plurality of columns comprise columns having a first length and columns having a second length greater than the first length claim 5 , and wherein the first length is equal to or less than 60% of the second length.7. The channel of claim 5 , wherein the plurality of columns comprise columns having a first length and columns having a second length greater than the first length claim 5 , and wherein each column having the first length is adjacent to at least another column having the first length.8. The channel of claim 1 , wherein the ...

MULTI-USE COMBINED MICRO AND NANOWELL PLATES

A multi-use combined micro and nanowell plate may provide nanowell arrays within the individual microwells of the plate. One or more microwells of the plate may provide an array of nanowells disposed at the bottom of the microwell. The combined micro and nanowell plate may be formed from a top frame with voids defining the microwells, and a bottom plate with voids defining the array of nanowells. When the top frame and the bottom plate are joined, the nanowell arrays may be aligned with the microwells to provide a combined micro/nanowell. 1. A multi-well plate providing combined microwell and nanowells , the plate comprising: a bottom array of nanowells, wherein each of the nanowells of the bottom array is a first void with a nanoliter to picoliter scale volume, and', 'a top microwell in fluidic communication with the bottom array, wherein the microwell is a second void with a microliter-scale volume, and the microwell is aligned with said bottom array of nanowells., 'a rectangular plate providing an array of combined wells, wherein each of the array of combined wells provides'}2. The plate of claim 1 , wherein the array of combined wells are arranged in an 8n×12n pattern of aligned rows and columns where n is an integer.3. The plate of claim 1 , wherein the rectangular plate comprises a top frame claim 1 , the top frame provides the second voids for the top microwells claim 1 , and the second voids span an entire thickness of the top frame.4. The plate of claim 3 , wherein the rectangular plate comprises a bottom plate claim 3 , the bottom plate provides the first voids for the bottom array of the nanowells claim 3 , and the first voids span less than an entire thickness of the bottom plate.5. The plate of claim 1 , wherein the plate provides an evaporation reservoir surrounding the array of combined wells.6. The plate of claim 1 , wherein the microwell is square claim 1 , circular claim 1 , hexagonal claim 1 , rectangular claim 1 , or diamond.7. The plate of claim ...

APPARATUS FOR SEPARATING MICRO-PARTICLES USING TRIANGULAR MICROCHANNEL

A micro-particle separation apparatus includes a triangular microchannel of which a cross-section is formed in the shape of a triangle and through which a fluid including a plurality of particles flows by a predetermined length; and an outlet that separates particles that have been arranged at different focusing positions in the triangular microchannel, and outputs the separated particles. The triangular microchannel has different focusing positions depending on particle size. 1. A micro-particle separation apparatus comprising:a triangular microchannel of which a cross-section is formed in the shape of a triangle and through which a fluid including particles with a plurality of sizes flows by a predetermined length; andan outlet that separates the particles that have been arranged at different focusing positions in the triangular microchannel, and outputs the separated particles ,wherein the triangular microchannel makes different focusing positions depending on particle size.2. The micro-particle separation apparatus of claim 1 , wherein claim 1 , in the triangular microchannel claim 1 , focusing positions shift along two side walls from the top corner of the cross-section of the channel as the particle size is decreased.3. The micro-particle separation apparatus of claim 2 , wherein claim 2 , in the triangular microchannel claim 2 , the particles are focused above and below the center of the cross-section of the channel depending on particle size or focused near each side wall of the triangular microchannel.4. The micro-particle separation apparatus of claim 1 , wherein claim 1 , in the triangular microchannel claim 1 , focusing position of particles with a specific size shifts along two side walls from the top corner of the cross-section of the channel as a Reynolds number is increased.5. The micro-particle separation apparatus of claim 4 , wherein the Reynolds number is changed by adjusting at least one of velocity of the fluid having flowed into the triangular ...

MICROFLUIDIC CARTRIDGE

The technology described herein generally relates to microfluidic cartridges configured to amplify and detect polynucleotides extracted from multiple biological samples in parallel. The technology includes a microfluidic substrate, comprising: a plurality of sample lanes, wherein each of the plurality of sample lanes comprises a microfluidic network having, in fluid communication with one another: an inlet; a first valve and a second valve; a first channel leading from the inlet, via the first valve, to a reaction chamber; and a second channel leading from the reaction chamber, via the second valve, to a vent. 1. (canceled)2. A microfluidic cartridge comprising: an inlet;', 'a reaction chamber downstream of the inlet;', 'a first channel in fluid communication with the inlet and the reaction chamber; and', 'a second channel downstream of the reaction chamber and in fluid communication with the reaction chamber, wherein the plurality of sample lanes comprise a first bank of sample lanes and wherein a first axis intersects the reaction chambers of the first bank, wherein the plurality of sample lanes comprise a second bank of sample lanes, wherein the reaction chambers of the first bank are a different distance from their respective inlets than the reaction chambers of the second bank are from their respective inlets, wherein a second axis intersects a reaction chamber of the first bank and a reaction chamber of the second bank, wherein the second axis is transverse to the first axis., 'a plurality of sample lanes, each of the sample lanes comprising3. The microfluidic cartridge of claim 2 , wherein the inlets of the sample lanes of the first bank and the inlets of the sample lanes of the second bank alternate.4. The microfluidic cartridge of claim 2 , wherein the inlets are aligned along a third axis.5. The microfluidic cartridge of claim 2 , wherein the inlets of the plurality of sample lanes are aligned.6. The microfluidic cartridge of claim 2 , wherein the inlets ...

TRANSPORT STRUCTURE FOR A PLURALITY OF VIALS FOR PHARMACEUTICAL, MEDICAL OR COSMETIC USE, STERILE PACKAGING STRUCTURE AND PROCESS FOR PROCESSING VIALS

A transport structure for accommodating a plurality of vials for pharmaceutical, medical or cosmetic use under non-sterile conditions is formed by an accommodation member and by a bearing member releasably connected thereto. The accommodation member comprises a plurality of frustro-conical receptacles in a regular arrangement so that the vials can be accommodated upright and while preventing a direct contact between adjacent vials in the receptacles of the accommodation member. The transport structure comprises latching structures for releasable latching of the accommodation member with the bearing member. According to the disclosure, the receptacles are matched to the height of the vials in such a manner that the vials can be completely accommodated therein, wherein the bearing member is formed by a base plate having a flat supporting surface facing the receptacles, so that the vials can be freely displaced on the supporting surface of the base plate after releasing the latching and can be pushed from the bearing member by displacement of the accommodation member relative to the bearing member. The accommodation member and/or the bearing member can be formed in one piece by thermoforming a plastic material, in particular by deep-drawing a thin film or a thin film plate. 1. A transport structure for accommodating a plurality of vials for pharmaceutical , medical or cosmetic use , wherein the transport structure is formed by an accommodation member and by a bearing member releasably connected thereto , and wherein:the accommodation member comprises a plurality of frustro-conical receptacles in a regular arrangement so that the upper ends of the vials are directed towards the bottoms of the receptacles and can be accommodated in the receptacles of the accommodation member while preventing a direct contact between adjacent vials;the bearing member covers the bottoms of the vials when the vials are accommodated in the accommodation member ;the receptacles are matched ...

Enhanced Hydration Methods and Systems for Histology

There is provided a histology system that comprises a microtome configured to expose a face of a tissue block comprising a tissue sample embedded in an embedding material and remove one or more tissue sections from the sample, a hydration system configured to hydrate the tissue block by depositing a hydrating liquid on the face of the tissue block, and a transfer system configured to transfer the one or more tissue sections from the microtome to one or more slides. In some embodiments, the hydration system is configured to produce droplet condensation of the hydrating liquid and deposit the condensation on the face of the tissue block. 1. A system for histology comprising:a microtome configured to expose a face of a tissue block comprising a tissue sample embedded in an embedding material and remove one or more tissue sections from the sample;a hydration system configured to hydrate the tissue block by depositing a hydrating liquid on the face of the tissue block; anda transfer system configured to transfer the one or more tissue sections from the microtome to one or more slides.2. The system of claim 1 , wherein the hydration system is configured to produce droplet condensation of the hydrating liquid and deposit the droplet condensation on the face of the tissue block.3. The system of claim 1 , wherein the hydration system comprises an ultrasonic humidifier.4. The system of claim 1 , wherein the hydration system comprises a sprayer assembly configured to spray the face of the tissue block with droplets of the hydrating liquid.5. The system of claim 1 , wherein the hydration system comprises a hydration chamber configured to receive one or more tissue blocks and a humidifier in communication with the hydration chamber to provide humid air to the hydration chamber.6. The system of claim 1 , wherein the hydrating liquid is deposited by spraying droplets of the hydrating liquid onto the face of the tissue block.7. The system of claim 1 , wherein the hydrating liquid ...

STIRRING METHOD AND STIRRING SYSTEM

A stirring system includes a vibration device configured to generate vertical vibration and a holder configured to hold liquid having a free surface and receive the vertical vibration from the vibration device. The stirring system further includes processing circuitry configured to generate a Faraday surface wave on the free surface of the liquid to stir the liquid by controlling at least one of an amplitude and a frequency of the vertical vibration. 1. A stirring method comprising:holding liquid having a free surface with a holder;applying vertical vibration to the holder with a vibration device; andgenerating a Faraday surface wave on the free surface of the liquid to stir the liquid by controlling at least one of an amplitude and a frequency of the vertical vibration.2. The stirring method according to claim 1 , further comprising controlling at least one of the amplitude and the frequency of the vertical vibration such that the Faraday surface wave is in a state of a standing wave claim 1 , spatiotemporal modulation claim 1 , chaos claim 1 , or a soliton.3. The stirring method according to claim 1 , further comprising controlling at least one of the amplitude and the frequency of the vertical vibration such that the Faraday surface wave changes from one of states of a standing wave claim 1 , spatiotemporal modulation claim 1 , a soliton claim 1 , and chaos to another one of the states.4. The stirring method according to claim 1 , further comprising intermittently generating the Faraday surface wave.5. The stirring method according to claim 1 , further comprising changing at least one of the amplitude and the frequency of the vertical vibration during stirring of the liquid.6. The stirring method according to claim 1 , further comprising:expanding and contracting an actuator of the vibration device in a horizontal direction, wherein the actuator has a free end configured to be displaced in the horizontal direction; andconverting the expansion and contraction in ...

REAGENT MANAGEMENT APPARATUS

A reagent management apparatus utilizing a flexible sheet that is foldable along scores into a disposable liner which may be freestanding via a “three point” structure. The disposable liner includes a reservoir for reagents and allows the pouring off of unused reagent into a storage container. The disposable liner may be used with a permanent base in certain cases. 1. A reagent management apparatus , comprising:an insert, said insert including a pliable sheet comprising first and second sections connected to one another and being foldable relative to one another, a third section being connected to said first section and a fourth section being connected to said second section, said first and third sections and said second and fourth sections being foldable relative to one another, a fifth section and a sixth section each connected to said first and second sections, said fifth and sixth sections being foldable relative to said first and second sections to form a reservoir for the reagent, said third and fourth sections having a longitudinal dimension less than said connected first, second, fifth, and sixth sections;a base, said base comprising a trough accommodating said reservoir formed by said first and second sections of said insert, said third and fourth sections each including a free edge portion, said base further including at least a first and second slot for encompassing said free edges of said third and fourth sections, respectively.2. The apparatus of in which at least one of said first and second slots includes a protrusion capable of contacting said insert.3. The apparatus of in which said base further includes an elongated opening position adjacent said folded first and second sections.4. The apparatus of in which said base further includes third and fourth slots for encompassing said free edges of said third and fourth sections.5. The apparatus of in which said insert is composed of water resistant material.6. The apparatus of in which said base ...

Processing Cartridge and Method for Detecting a Pathogen in a Sample

In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence. 1. A method of motivating a sample through a cartridge , the method comprising:(a) motivating the sample on a first substrate using microfluidics; and(b) motivating the sample on a second substrate using electrowetting, thereby motivating a sample through a cartridge, wherein (a) is not accomplished by electrowetting.2. The method of claim 1 , further comprising claim 1 , after (b) claim 1 , motivating the sample into an electrosensor array located on the second substrate.3. The method of claim 1 , wherein (a) comprises pumping the sample from a first location to a second location.4. The method of claim 1 , wherein (a) comprises compressing a fluid-filled deformable compartment supported on the first substrate claim 1 , thereby generating pressure to move the sample.5. The method of claim 1 , wherein (a) comprises introducing magnetic beads to the sample and applying a magnetic force to move the sample.6. The method of claim 1 , wherein (a) comprises introducing negatively-charged capture beads to the first substrate to facilitate adsorption of positively-charged nucleic acids from the sample to a surface of the negatively-charged capture beads claim 1 , thereby moving the sample.7. The method of claim 1 , further comprising introducing process fluids into the first substrate by compressing a fluid-filled deformable compartment supported on the first ...

MICROFLUIDIC SYSTEM

A microfluidic system for the isolation of particles of at least one given type belonging to a sample and comprising a separation unit, which is designed to transfer the particles of given type from a main chamber to a recovery chamber in a substantially selective manner with respect to further particles of the sample; at least one first reservoir, which is designed to contain a liquid and is fluidically connected to the separation unit; and a regulating assembly, which comprises at least a first regulating device having a first heat transfer element arranged at the first reservoir to adjust the temperature of the first reservoir, in particular to absorb heat from the reservoir. 1. A microfluidic system for the isolation of particles of at least one given type from a sample; the microfluidic system comprising:an inlet, through which, in use, the sample is introduced into the microfluidic system;a separation unit, which comprises a main chamber and a recovery chamber and is designed to transfer at least part of the particles of the given type from the main chamber to the recovery chamber in a selective manner with respect to further particles of the sample;at least one first reservoir having an inner volume of at least 1 μL, which is designed to contain a liquid and is fluidically connected to the separation unit; andat least one actuator to move the liquid from the first reservoir to the separation unit;the microfluidic system being characterized in that it comprises a regulating assembly, which comprises at least one first regulating device having at least one first heat transfer element which is arranged at the first reservoir so as to absorb heat from the first reservoir itself; the separation unit comprising a system selected from the group consisting of dielectrophoresis, optical tweezers, magnetophoresis, acoustophoresis and a combination thereof.2. The microfluidic system according to claim 1 , wherein the regulating assembly comprises a control device claim ...

SYSTEMS AND METHODS FOR BLOOD SAMPLE PRESERVATION AND HEMATOCRIT SEPARATION

A system for preserving a blood sample and removing hematocrit includes a casing, the casing having a sample port and a lateral flow strip in the casing, the lateral flow strip receiving a sample through the sample port, and flowing the sample down a length of the lateral flow strip. 1. A system for preserving a blood sample and removing hematocrit , comprising:a casing, the casing having a sample port; anda lateral flow strip in the casing, the lateral flow strip receiving a sample through the sample port, and flowing the sample down a length of the lateral flow strip.2. The system of claim 1 , further comprising:a blood separation layer in the casing on top of the lateral flow test strip, oriented in line with the sample port.3. The system of claim 2 , wherein the blood separation layer is approximately a length of the sample port and the lateral flow strip is a length of the casing.4. The system of claim 3 , wherein the blood separation layer includes a uniform screen side and the lateral flow strip includes a uniform screen side; and the uniform screen side of the blood separation layer is oriented away from the sample port towards the lateral flow strip;and the uniform screen side of the lateral flow strip is oriented towards the blood separation layer.5. The system of claim 1 , wherein the casing includes a vent claim 1 , the vent distal from the sample port.6. The system of claim 4 , further comprising a nylon layer oriented in the casing under the lateral flow test strip.7. The system of claim 6 , further comprising a cap claim 6 , the cap sized to fit in the sample port of the casing.8. The system of claim 7 , wherein the blood separation layer has been impregnated with inert ingredients to make it hydrophilic and allow red blood cell filtration.9. The system of claim 8 , wherein the inert ingredients are poly vinyl alcohol and a wetting agent.10. The system of claim 8 , wherein the inert ingredients are poly vinyl alcohol and lectins.11. The system of ...

ANALYSIS DEVICES, ANALYSIS KITS, AND ANALYSIS SYSTEMS

An analysis apparatus including a stage, an analysis device placed on the stage and including receiving sections which accommodate a sample and a reagent for biochemical reaction, and are communicated with one another through a flow path having an inlet and an outlet, a liquid introduction section which is connected to the inlet and supplies into the flow path the sample, the reagent, and an sealing liquid for sealing each of the receiving sections, and a waste liquid storage section which is connected to the outlet and stores as waste liquid an excess of the sample and the reagent and a part of the sealing liquid supplied to the flow path, an optical system which includes an objective lens, emits excitation light to the receiving sections and allows observation of fluorescence generated in the receiving sections by the excitation light, and a control unit that controls such that the sealing liquid and the excess of the sample and the reagent form an interface in the waste liquid storage section, and that the interface is formed at a distance not less than a fluorescence-obtainable distance from a bottom of the receiving sections. 1. An analysis apparatus , comprising:a stage; a plurality of receiving sections configured to accommodate a sample and a reagent for biochemical reaction, and communicated with one another through a flow path having an inlet and an outlet,', 'a liquid introduction section connected to the inlet and configured to supply into the flow path the sample, the reagent, and an sealing liquid for sealing each of the receiving sections, and', 'a waste liquid storage section connected to the outlet and configured to store as waste liquid an excess of the sample and the reagent and a part of the sealing liquid supplied to the flow path;, 'an analysis device placed on the stage and including'}an optical system including an objective lens and configured to emit excitation light to the receiving sections and allow observation of fluorescence generated ...

LATERAL CAVITY ACOUSTIC TRANSDUCER (LCAT) FOR SHEAR-INDUCED CELL TRANSFECTION

The present invention features the use of lateral cavity acoustic transducers (LCATs) to apply mechanical stimuli on cells. LCATs utilize the generated acoustic microstreaming vortices to trap cells and apply tunable shear-induced cell deformation on them. The present invention may use such a portable, automated, and high throughput device for shear-induced cell transfection. 1. A high-throughput method for transfecting a cell , comprising:{'b': 110', '120', '130', '130', '120', '110', '140, 'a. providing a microfluidic platform () comprising a main microfluidic channel (), and one or more lateral cavity acoustic transducers (LCATs) (), wherein the one or more LCATs () are dead-end side channels coupled to the main microfluidic channel (), wherein the microfluidic platform () is coupled to an external acoustic source ();'}{'b': 150', '120', '150', '160', '170', '150', '130', '180, 'b. flowing a fluid () through the main microfluidic channel (), said fluid () comprising a cell () and an exogenous material (), wherein the fluid () intersects the LCATs () to form one or more gas-liquid interfaces (); and'}{'b': 130', '140', '180', '180', '190', '160', '170', '160', '170', '160, 'c. applying acoustic energy to the LCATs () via the external acoustic source () to oscillate the gas-liquid interfaces (), wherein oscillating the liquid-gas interfaces () produces a plurality of microstreaming vortices () that trap cells () and exogenous material () therein, thereby shear-inducing mechanical deformation of the cells (), and allowing for delivery of the exogenous material () into the cell ().'}2130120. The method of claim 1 , wherein the LCATs () intersect the main channel () at an angle.3. The method of claim 1 , additionally comprising:{'b': 200', '110, 'a. providing an array of electrodes (), the electrodes interdigitated with the microfluidic platform (); and'}{'b': 200', '160, 'b. applying a voltage to the electrodes () so as to achieve electroporation of the cell ().'} ...

System and method for multi-axis imaging of specimens

A specimen holding and positioning apparatus operable to substantially non-movably maintain a specimen (e.g., an excised tissue specimen) in a fixed or stable orientation with respect to the apparatus during imaging operations (e.g., x-ray imaging), transport (e.g., from a surgery room to a pathologist's laboratory), and the like for use in facilitating accurate detection and diagnosis of cancers and/or other abnormalities of the specimen.

MICROFLUIDIC CARTRIDGE FOR PROCESSING AND DETECTING NUCLEIC ACIDS

A system, configured to facilitate processing and detection of nucleic acids, the system comprising a process fluid container and a cartridge comprising: a top layer, a set of sample port-reagent port pairs, a shared fluid port, a vent region, a heating region, and a set of detection chambers; an intermediate substrate, coupled to the top layer comprising a waste chamber; an elastomeric layer, partially situated on the intermediate substrate; and a set of fluidic pathways, each formed by at least a portion of the top layer and a portion of the elastomeric layer, wherein each fluidic pathway is fluidically coupled to a sample port-reagent port pair, the shared fluid port, and a detection chamber, comprises a portion passing through the heating region, and is configured to be occluded upon deformation of the elastomeric layer, to transfer a waste fluid to the waste chamber, and to pass through the vent region. 1. A system for processing a sample , the system comprising a cartridge comprising:a first layer comprising a sample port;an intermediate substrate that is coupled to the first layer, partially separated from the first layer by a film layer, and configured to form a sealed waste chamber and a waste port into the sealed waste chamber, wherein the sealed waste chamber directly opposes the first layer across the film layer and defines an external void; anda fluidic pathway, superior to the intermediate substrate and at least partially separated from the sealed waste chamber by a deformable layer, wherein the fluidic pathway is fluidly coupled to the sample port, and wherein the fluidic pathway operates in an occluded mode in which the deformable layer is deformed by an occluder passing through the external void defined by the waste chamber, the occluded mode allowing waste fluid of the sample to be transmitted through the waste port into an interior portion of the sealed waste chamber.2. The cartridge of claim 1 , wherein the fluidic pathway is defined between the ...

SYSTEMS AND METHODS FOR INSPECTING A MICROFLUIDIC ROTOR DEVICE

Described herein are various embodiments directed to rotor devices, systems, and kits. Embodiments of rotors disclosed herein may be used to characterize one or more analytes of a fluid. A method may include aligning an apparatus to an imaging device. The apparatus may include a set of wells defined by a first layer coupled to a second layer. The first layer may be substantially transparent to infrared radiation. The second layer may define a channel. The second layer may be substantially absorbent to the infrared radiation. The apparatus may further include a third layer coupled to the second layer and define an opening configured to receive a fluid. The third layer may be substantially transparent to the infrared radiation. A set of images of the apparatus may be generated using the imaging device. Bonding information may be generated based on the set of images. 1. A method , comprising:aligning an apparatus to an imaging device, the apparatus including a set of wells defined by a first layer coupled to a second layer, the first layer being substantially transparent to infrared radiation, the second layer defining a channel, the second layer being substantially absorbent to the infrared radiation, the apparatus further including a third layer coupled to the second layer and defining an opening configured to receive a fluid, the third layer being substantially transparent to the infrared radiation;generating a set of images of the apparatus using the imaging device;generating bonding information based on the set of images, the bonding information including a set of edges and gaps formed between the second layer and the third layer; andclassifying a weld quality of the apparatus using the bonding information.2. The method of claim 1 , wherein the set of images includes one or more of a plan view of the apparatus claim 1 , a bottom view of the apparatus claim 1 , a side view claim 1 , and a skew view of the apparatus.3. The method of claim 1 , the generating the set ...

DIAGNOSTIC ASSAY STRIP CASSETTE

A cassette removably holds assay strips. The cassette includes a cover and a base. The base includes a first face and a second face, the second face opposed across a thickness of the base from the first face. The base has at least a first channel in the first face that extends along at least a portion of the base, the at least first channel having a width, a length and a depth, at least the width and the depth of the first channel sized to at least partially receive an assay strip therein. The cover has a first face and a second face, the second face opposed across a thickness of the cover from the first face. The cover is releasably securable to the base in at least two orientations to alternatively expose a first set of markings and a second set of markings. The first and the second set of markings are carried by at least one of the cover or the base. The first set of markings is indicative of a first type of assay strip and the second set of markings is indicative of a second type of assay strip; the second set of markings being different from the first set of markings. The two different orientations include a first orientation in which the first face of the cover is exposed and the second face of the cover is adjacent one of the first or the second faces of the base, and a second orientation in which the second face of the cover is exposed and the first face of the cover is adjacent one of the first or the second faces of the base. 1. A cassette to removably hold assay strips , comprising:a base, the base having a first face and a second face, the second face opposed across a thickness of the base from the first face, the base having a first channel in the first face that extends along at least a portion of the base, the first channel having a width, a length and a depth, at least the width and the depth of the first channel sized to closely removably receive an assay strip therein; anda cover, the cover having a first face and a second face, the second face ...

MULTI-DIMENSIONAL DOUBLE SPIRAL DEVICE AND METHODS OF USE THEREOF

Described is a multi-dimensional double spiral (MDDS) microfluidic device comprising a first spiral microchannel and a second microchannel, wherein the wherein the first spiral microchannel and second spiral microchannel have different cross-sectional areas. Also described is a device comprising a multi-dimensional double spiral and system for recirculation. The invention also encompasses methods of separating particles from a sample fluid comprising a mixture of particles comprising the use of the multi-dimensional double spiral microfluidic device. 1. A microfluidic device comprising a multidimensional double spiral (MDDS) , wherein the MDDS comprises:a. a first spiral microchannel comprising a first inlet;b. a second spiral microchannel in fluid communication with the first spiral microchannel and comprising an inner wall outlet and an outer wall outlet, wherein the inner wall outlet is located on the inner wall side of the microchannel and the outer wall outlet is located on the outer wall side of the microchannel; andc. a transition region, wherein the transition region is a microchannel that connects the first and second spiral microchannels, wherein the output from the first spiral microchannel is directed into the second spiral microchannel in the transition region;wherein the first spiral microchannel has a smaller cross-sectional area than the second spiral microchannel;wherein the cross-sectional area of the first spiral microchannel remains constant along its length and wherein the cross-sectional area of the second spiral microchannel remain constant along its length;wherein the MDDS is configured to separate particles from a sample fluid comprising a mixture of particles;wherein the first spiral microchannel is configured to concentrate the particles into a concentrated particle stream and the second spiral microchannel is configured to separate particles from the concentrated particle stream based on their sizes;wherein the first spiral microchannel ...

Method and device for high field strength electrotransfection of microvescicles and cells

A device, system and process involve conducting electroporation of microvesicles or exosomes or other target structures in a microfluidic arrangement at pressures that exceed atmospheric pressure. Single as well as multiple flow configurations can be employed. In some cases, the system and its operation are computer-controlled for partial or complete automation.

APPARATUS FOR SPREADING A FLUID ACROSS A SUBSTRATE AND METHOD OF USING THE SAME

This disclosure is directed to an apparatus and method for spreading a fluid across a substrate. A spreader for spreading a fluid across a substrate includes a wiper and a frame. The wiper and the frame may mate to permit translation of the wiper across, and with respect to, the frame. The wiper spreads the fluid across the substrate and the frame supports the wiper and the substrate. The frame may also include a ramp to cause a portion of the wiper to lift away from the substrate. 1. A wiper comprising:a main body; and a blade that extends at least partially downwardly to engage a fluid on a substrate, and', 'at least one flexure,', 'wherein the at least one flexure permits flexion of the blade relative to the main body., 'a platform extending outwardly from the main body, the platform including'}2. The wiper of claim 1 , the wiper further comprising a connector to accept and hold a vessel at least partially filled with the fluid claim 1 , the connector comprising:an attachment segment to attach to the main body of the wiper;a pedestal extending away from the attachment segment and towards the blade of the wiper; anda bore extending through the pedestal.3. The wiper of claim 2 , wherein the bore of the connector is threaded or includes a Luer lock.4. The wiper of claim 2 , wherein the bore includes a needle to puncture the vessel.5. The wiper of claim 4 , wherein the vessel comprises a tubular main body with a flexible bottom and a cap to be punctured by the needle claim 4 , such that when the flexible bottom is pushed claim 4 , a pre-determined volume of fluid is drawn through the needle and then dispensed onto the substrate from the needle.6. The wiper of claim 1 , wherein the blade of the wiper is rectangular claim 1 , semi-spherical claim 1 , triangular claim 1 , or tapered.7. The wiper of claim 1 , wherein the blade is rubber claim 1 , plastic claim 1 , ceramic claim 1 , metal claim 1 , or combinations thereof.8. The wiper of claim 1 , further comprising a ...

UNITARY CARTRIDGE FOR PARTICLE PROCESSING

A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles. 1. A particle sorting system comprising: a particle sorting component configured to receive a stream of particles and to individually sort on a particle-by-particle basis the stream of particles into selected particles having a predetermined characteristic and unselected particles not having the predetermined characteristic;', 'a particle source upstream of and in fluid communication with the particle sorting component for providing particles to be sorted to the particle sorting component;', 'a first chamber downstream of and in fluid communication with the particle sorting component for collecting the selected particles;', 'a second chamber downstream of the particle sorting component for collecting unselected particles; and', 'one or more sealing elements configured to completely seal the cartridge during a particle sorting operation so as to prevent liquid transfer to and from the interior of the cartridge., 'a cartridge including2. The particle sorting system of claim 1 , wherein the particle source chamber is configured to provide particles to be sorted to the particle sorting component when an external source of pressure is applied to the particle source chamber.3. The particle sorting system of claim 1 , further comprising:a sealable loading port formed in the cartridge for providing particles to the particle source chamber; andan extraction port formed in the cartridge for removing selected particles from the first chamber.4. The particle sorting system of claim 1 , further ...

Reusable specimen imaging device holder system with replaceable membranes

The present invention is for the retention of surgically removed tissue for radiographic imaging. In breast conservation surgery specimen radiographic imaging is used to evaluate the success of removed diseased tissue with a negative margin. Accurate positioning of tissue orientation with minimal compression of the removed pathologic neoplasm is employed. The radiolucent device holder's purpose is to secure the tissue in proper orientation for radiographic imaging and margin evaluation. The present invention is a reusable system. It features a snap together component that allows for the replacing of the radiolucent membranes. Components are properly disinfected and membranes replaced making the device holder ready for reuse. This reusability is innovative, more cost effective and reduces medical waste. While this present invention, reusable specimen imaging holder device system with replaceable membranes has particular use in breast conservation surgery specimen imaging for optimal margin evaluation it is not exclusive to that purpose. 1. The method of a reusable specimen imaging device holder system which utilizes replaceable membranes. The device holder system may be provided in a plurality of sizes and shapes and still applicable to the system in the method claimed.2414243. The method in where the structural components of the device holder have a top and bottom unit claim 1 , CV. and CV . with a snap on component that secures the membranes to them claim 1 , (CV .).34144. The method in of placing the tissue sample for radiographic imaging occurs by placing the sample on the surface of the membrane on CV . claim 1 , allowing the sample to be “sandwiched” between each membrane of the holder claim 1 , then closing and latching the holder. (CV .)4. The method in where the device may be disinfected and the membranes changed for reuse. This invention relates to an apparatus for holding surgically excised breast tissue for radiographic imaging for the purpose of optimal ...

SPECIMEN PROCESSING METHOD, SPECIMEN PROCESSING APPARATUS, NON-TRANSITORY COMPUTER-READABLE STORAGE MEDIUM, AND SPECIMEN PROCESSING CARTRIDGE

According to one or more aspects, a specimen processing method may use a cartridge comprising a chamber configured to store a liquid. The method may include: storing a specimen and a dispersion medium in the chamber of the cartridge; and rotating the cartridge about a rotational shaft to agitate the specimen and the dispersion medium in the chamber, to thereby form an emulsion in which a dispersoid containing the specimen is dispersed in the dispersion medium. 1. A specimen processing method that uses a cartridge comprising a chamber configured to store a liquid , the method comprising:storing a specimen and a dispersion medium in the chamber of the cartridge; androtating the cartridge about a rotational shaft to agitate the specimen and the dispersion medium in the chamber, to thereby form an emulsion in which a dispersoid containing the specimen is dispersed in the dispersion medium.2. The specimen processing method according to claim 1 , wherein the cartridge comprises a plurality of chambers arranged in an arc form whose radial distances from the rotational shaft are substantially equal.3. The specimen processing method according to claim 1 , whereinthe rotating the cartridge about the rotational shaft to form the emulsion comprises changing a rotational speed of the cartridge repeatedly.4. The specimen processing method according to claim 3 , wherein reversing a rotational direction of the cartridge; or', 'accelerating and decelerating the rotational speed of the cartridge in one direction., 'the changing the rotational speed of the cartridge comprises5. The specimen processing method according to claim 4 , whereinthe changing the rotational speed of the cartridge comprises reversing the rotational direction of the cartridge in a cycle of 165 milliseconds or more and 330 milliseconds or less.6. The specimen processing method according to claim 3 , whereina ratio of a total volume of the dispersoid and the dispersion medium to the chamber is 30% or more and 70% ...

Optics Cup With Curved Bottom

The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria, in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optics cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light. The system may utilize the disposable cartridge in the sample processor and the optics cup or cuvette in the optical analyzer, wherein the optics cup also has a floor in the shape of an inverted arch. 116-. (canceled)17. A disposable cartridge for use in the identification and quantification of micro-organisms in biological samples , comprising:the disposable cartridge including an optics cup contained in a compartment adapted to contain the processed biological sample for use in an optical analysis;the optics cup having a generally rectangular shape with opposing sidewalls having a longitudinal axis therebetween and a tapered area extending from a first end wall of the optics cup into which a light source travels for the optical analysis of the processed biological sample and a reflective surface for enhancing the optical analysis, wherein the tapered area extends in a direction outwardly as the second end wall extends upwardly from the floor;the compartment for positioning and supporting the optics cup having a rectangular-shaped opening for receiving and supporting the rectangular-shaped optics cup;wherein the tapered area of the optics cup extends downwardly to a floor,wherein the floor has the shape of an inverted arch extending continuously along the entire length of the floor, andwherein the inverted arch is symmetric about the longitudinal axis.18. The disposable cartridge according to claim 17 , wherein the disposable cartridge includes a compartment for receipt of a pipette tip.19. The disposable cartridge according to claim 17 , wherein the compartment for positioning and ...

MAGNETIC RACK

A magnetic rack includes a bottom plate; a top plate mounted onto the bottom plate, the top plate having therein a first plurality of tube holes for retaining one or more tubes, each tube hole having an opening and a supporting wall extending from the opening between the top plate and the bottom plate; and a second plurality of magnetic assemblies distributed between at least a portion of the first plurality of tube holes, each magnetic assembly being configured to produce a magnetic field in one or more tube holes adjacent thereto. 1. A magnetic rack , comprising:a bottom plate;a top plate mounted onto the bottom plate, the top plate having therein a first plurality of tube holes for retaining one or more tubes, each tube hole having an opening and a supporting wall extending from the opening between to the top plate and the bottom plate; anda second plurality of magnetic assemblies distributed between at least a portion of the first plurality of tube holes, each magnetic assembly being configured to produce a magnetic field in one or more tube holes adjacent to the magnetic assembly;wherein each tube hole partially overlaps with a magnetic assembly adjacent to the tube hole such that a portion of the adjacent magnetic assembly protrudes into the tube hole through the supporting wall of the tube hole.2. (canceled)3. The magnetic rack of claim 1 , wherein each magnetic assembly comprises a cylindrical magnet.4. The magnetic rack of claim 1 , wherein both the first plurality of tube holes and the second plurality of magnetic assemblies are arranged in rectangular arrays claim 1 , and each magnetic assembly is positioned at a center of a group of four tube holes of the first plurality of tube holes claim 1 , and wherein the group of four tube holes are adjacent to the magnetic assembly.5. The magnetic rack of claim 4 , wherein each tube hole is adjacent to a magnetic assembly.6. The magnetic rack of claim 1 , wherein the second plurality of magnetic assemblies are ...

PIPETTE TIP HANDLING DEVICES AND METHODS

Discussed herein are methods and devices for storing, handling, loading or dispensing of pipette tips. Some embodiments allow repetitive loading of an array of multiple pipette tips that are stored in a nested configuration. 1. (canceled)2. A method for simultaneously dispensing an array of pipette tips into a loading block , comprising:(a) providing a dispensing device that includes an array of nested pipette tip units and a distal barrier plate comprising a substantially flat top surface, a substantially flat bottom surface, a first subset of channels and a second subset of channels, wherein each channel has a diameter larger than the widest portion of a pipette tip each of which nested pipette tip units is aligned with a channel in the distal barrier plate, whereby a one-layer pipette tip array is aligned with the channels;(b) engaging the dispensing device with a loading block such that distal ends of pipette tips are disposed above or within receptacles of the loading block:(c) actuating an actuator of the dispensing device so as to apply an axial force on the array of pipette tips, wherein the axial force dispenses the array of pipette tips through the first subset of channels at a different time than the second subset of channels, thereby ejecting the array of pipette tips into respective receptacles in the loading block.3. The method of claim 2 , wherein the channels comprise one or more channel features in or around each of the channels in the first subset of channels and one or more channel features in or around each of the channels in the second subset of channels claim 2 ,the one or more channel features in or around each of the channels in the first subset of channels confer a first frictional force to the pipette tips in the array ejected through the first subset of channels and the one or more channel features in or around each of the channels in the second subset of channels confer a second frictional force to the pipette tips in the array ejected ...

SLIDE STAINING ASSEMBLY AND COVER MEMBER

A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided. 1. A cover member for use in a sample processing assembly , the cover member having:a. a first side;b. a second side opposing the first side;c. a void on a first side, the void forming a reaction chamber when the cover member contacts a substrate; andd. at least one notch;wherein the cover member is configured for releasable engagement with a closure body of the sample processing assembly and the at least one notch is shaped to cooperate with a corresponding protrusion on one of a mounting surface of the sample processing assembly and the closure body of the sampling processing assembly such that when in use, the notch and protrusion guide the cover member into position in the assembly to form a reaction chamber with a substrate.2. A cover member according to claim 1 , manufactured at least in part from a material selected from the group including: polycarbonate claim 1 , polyoxymethylene (acetal) claim 1 , polyether ether ketone (PEEK) claim 1 , polyethylenes including high density polyethylene (HDPE) and ultra-high molecular weight polyethylene (UHMW-PE) claim 1 , Teflons including Teflon PE and polypropylenes including fluorinated ethylene propylene (FEP) claim 1 , and Cyclic Olefin Copolymers (COC).3. A cover member according to including at least one biasing arm configured such that when in use in a sample processing assembly claim 1 , the biasing arm abuts a reference member on the closure body and claim 1 , during final closure ...

ASSAY WITH RAPID TEMPERATURE CHANGE

The present invention provides devices, systems, and methods for rapid and easy-to-use in sample thermal cycling or temperature changes for the facilitation of reactions such as but not limited to PCR. 1. A device for assaying a thin fluidic sample layer , comprising: i. the first plate and the second plate are movable relative to each other into different configurations, including an open configuration and a closed configuration;', 'ii. each of the plates comprises, on its respective surface, a sample contact area for contacting a fluidic sample;', 'iii. one or both of the plates comprise the spacers that are fixed to the respective plate;', 'iv. the spacers have a predetermined substantially uniform height that is equal to or less than 200 microns, wherein at least one of the spacers is inside the sample contact area; and', 'v. the clamp compresses the first plate and the second plate to fix the two plates together at the closed configuration, wherein the pressure of the clamp applied on the plates is 0.01 kg/cm{circumflex over (\u2003)}2 or higher,, 'a first plate, a second plate, spacers, and a clamp, whereinwherein in an open configuration, the two plates are partially or completely separated apart, the spacing between the plates is not regulated by the spacers, and the sample is deposited on one or both of the plates; andwherein in a closed configuration, which is configured after the sample is deposited in the open configuration, at least a part of the sample is compressed by the two plates into a layer of substantially uniform thickness and is substantially stagnant relative to the plates, wherein the uniform thickness of the layer is confined by the sample contact areas of the two plates and is regulated by the plates and the spacers.2. A device for rapidly changing temperature of a thin fluidic sample layer , comprising: i. the first plate and the second plate are movable relative to each other into different configurations, including an open configuration ...

Device For Detection Of Target Molecules And Uses Thereof

Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed. 122-. (canceled)23. A method of detecting a target molecule , the method comprising:contacting a sample with a device, the device comprising a housing, the housing comprising a first housing member, a second housing member, and inlet opening,wherein the housing further comprises: wherein the membrane detection system comprises:', 'a conjugate pad comprising a first capture reagent;', 'a permeable membrane;', 'a test membrane comprising a second capture reagent; and', 'two absorbent members;, 'a membrane detection system,'}a force member configured to apply pressure substantially perpendicular to the membrane detection system, wherein the vertical axis of the force member is substantially perpendicular to the membrane detection system;a slidable locking member contacting the force member;an attachment member in contact with the locking member; anda sliding button attached to the slidable locking member,wherein the conjugate pad, the permeable membrane, the test membrane; and the two absorbent members are substantially parallel to each other and the inlet opening,wherein the inlet opening is in fluid contact with the membrane detection system,wherein the slidable locking member is configured to move the conjugate pad when the slidable locking member is moved,wherein the sample contacted with the sample vertically flows from the conjugate pad to the test membrane;moving the conjugate pad after a portion of the sample has contacted and flowed through the conjugate pad, thereby exposing at least a portion of the test membrane for detection; andidentifying a positive or negative reaction for the target molecule,wherein the conjugate pad is operably connected to the slidable locking member and the conjugate pad is moved by moving the slidable locking member.24. The method of claim 23 , wherein the force member is in contact with one of the ...

A container and cooler arrangement

A laboratory fluid receptacle cooler arrangement () for sustaining a desired temperature range, comprising a housing (), a lid () covering an open top side of said housing (), and an aperture closing element (), wherein: the aperture closing element () at least partly covers said lid () and has a number of apertures (). The lid also () comprises a number of apertures (). The aperture closing element () is movable relative to the lid between open and closed positions, the aperture closing element and the lid having matching aperture configuration, thereby providing throughholes when the aperture closing element and the lid are in open configuration. Also, a cooler closure arrangement () with an aperture closing element () on top of a lid () where the aperture closing element () and the lid () are parallel and substantially plane rectangles in slideable engagement with each other. 11016321611. A laboratory fluid receptacle cooler arrangement () for improved microclimate control therein , comprising a housing () , a lid () covering an open top side of said housing () , and an aperture closing element () , wherein:{'b': 11', '32, 'said aperture closing element () at least partly covers said lid (),'}{'b': 11', '14, 'said aperture closing element () has a number of apertures (),'}{'b': 32', '44, 'said lid () has a number of apertures (),'}{'b': '11', 'said aperture closing element () is movable relative to the lid between an open and a closed position, and'}{'b': 11', '10, 'the aperture closing element and the lid has matching aperture configuration, thereby providing through holes when the aperture closing element and the lid are in an open configuration, whereby the aperture closing element () facilitates sustaining a desired temperature range within said laboratory fluid receptacle cooler arrangement ().'}21011144432. A laboratory fluid receptacle cooler arrangement () according to claim 1 , wherein said aperture closing element () has the same number of apertures () ...

HOLDER HAVING A STACK OF COVERSLIPS OR SPECIMEN SLIDES

A holder () for holding a stack () of coverslips () or specimen slides () has a bottom () having at least one side wall () connected thereto, wherein an inner side of the bottom () is embodied for placement of the stack () of coverslips () or specimen slides () and carrying that stack (), and an outer side of the bottom () and/or an outer side of the at least one side wall is configured to receive an identification label, such as an RFID (), and the holder includes such the identification label, such as an RFID (). 140101111. A holder () for holding a stack () of coverslips () or specimen slides () , the holder comprising:{'b': 20', '20', '10, 'a bottom () having an inner side and an outer side, the inner side of the bottom () being configured to support the stack ();'}{'b': 21', '21', '22', '22', '21', '21', '22', '22', '6', '20', '20', '21', '21', '22', '22, 'i': a', 'b', 'a', 'b', 'a', 'b', 'a', 'b', 'a', 'b', 'a', 'b, 'at least one side wall (, , , ) connected to the bottom, the at least one side wall (, , , ) having an outer side and having a delimiting line () facing away from the bottom (), wherein the outer side of the bottom () and/or the outer side of the at least one side wall (, , , ) is configured to receive an identification label; and'}{'b': '20', 'an identification label received by the outer side of the bottom () and/or the outer side of the at least one side wall;'}{'b': 6', '20, 'wherein the delimiting line () lies in a plane that encloses an acute angle with a plane defined by the bottom ().'}24020220232023202202. The holder () according to claim 1 , wherein the outer side of the bottom () comprises a receptacle () extending perpendicularly to the bottom () and a spacer () extending substantially perpendicularly to the bottom () claim 1 , wherein the spacer () extends in a direction perpendicular to the bottom () at least as far as the receptacle () extends in the direction perpendicular to the bottom () claim 1 , wherein the identification label ...

Method and Dispensing Device for Dispensed Fluid Output

A dispensing device which has a dispensing channel extending between a supply opening and an output opening into the course of which a pump, a selection valve and a dispensing valve are connected. The selection valve is also connected to a pressurised air source. The dispensing device allows a dispensed output of a fluid, wherein a buffer channel portion is filled by the pump in a pump dispensing phase, to which buffer channel portion pressure is applied from the pressurised air source during a pressurised air dispensing phase such that a precise fluid output is subsequently possible by clocked actuation of the dispensing valve until the target fluid amount has been reached. 1. A method for dispensed output of a fluid at an output opening of a dispensing channel of a dispensing device , the method comprising:(a) outputting a first proportion of a target fluid amount to be output by means of a pump connected into the dispensing channel which pump sucks the fluid to be dispensed via a supply opening of the dispensing channel from a fluid reservoir;(b) applying pressurised air to a buffer channel portion of the dispensing channel upstream of the output opening, which buffer channel portion is separated both from the output opening and from the pump and is filled with fluid sucked by the pump such that the buffer channel portion including a fluid buffer volume confined therein is placed under pressure; and(c) subsequently outputting, in a clocked manner, the remaining proportion of the target fluid amount to be dispensed from the buffer channel portion, which is separated from the pump and pressurised by the pressurised air, by means of a dispensing valve arranged between the buffer channel portion and the output opening in the dispensing channel, which dispensing valve is switched alternately into an open position allowing a fluid passage and into a closed position preventing a fluid passage.2. The method according to claim 1 , wherein the actual fluid amount actually ...

Multi-through Hole Testing Plate for High Throughput Screening

A method for holding samples for analysis and an apparatus thereof includes a testing plate with a pair of opposing surfaces and a plurality of holes. Each of the holes extends from one of the opposing surfaces to the other one of the opposing surfaces. The holes are arranged in groups, where each group has at least two rows and two columns of holes. The groups are arranged in sets, where each set has at least two rows and two columns of groups. To analyze samples, at least one of the opposing surfaces of the testing plate is immersed in a solution to be analyzed. A portion of the solution enters openings for each of the holes in the immersed opposing surface. Once the holes are filled with solution, the testing plate is removed and is held above a supporting surface. Surface tension holds the solution in each of the holes. The solution in one or more of the holes is then analyzed and the solution in one of these holes is identified for further study. The location of the identified solution is marked based upon its location within a particular set and group of holes. 126-. (canceled)27. A system , comprising: a first surface;', 'an opposing second surface; and', 'a plurality of through holes extending from the first surface to the second surface, the through holes being sized to provide sufficient surface tension to hold respective liquid samples;, 'a substrate configured to hold a liquid sample, the substrate comprisinga first plate comprising a bottom surface; anda second plate comprising a top surface;optics configured to analyze the liquid sample;wherein the through holes are disposed between the top surface and the bottom surface;wherein there is a space between the first surface of the substrate and the top surface;wherein there is a space between the second surface of the substrate and the bottom surface.28. The system of further comprising a detector configured detect a change in a solution contained in at least one of through holes.29. The system of claim ...

MICROFABRICATED DEVICE WITH MICRO-ENVIRONMENT SENSORS FOR ASSAYING COAGULATION IN FLUID SAMPLES

The present invention relates to sample analysis cartridges comprising micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using micro-environment sensors in a point of care sample analysis cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample, and a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber. The conduit may include a micro-environment prothrombin time (PT) sensor, and a micro-environment activated partial thromboplastin time (aPTT) sensor. 1. A sample analysis cartridge comprising:an inlet chamber configured to receive a biological sample; and a micro-environment prothrombin time (PT) sensor; and', 'a micro-environment activated partial thromboplastin time (aPTT) sensor., 'a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber, the conduit comprising2. The sample analysis cartridge of claim 1 , wherein the PT sensor is an electrochemical sensor.3. The sample analysis cartridge of claim 2 , wherein the PT sensor is configured to connect with an electrical connector of a test meter.4. The sample analysis cartridge of claim 1 , wherein the aPTT sensor is an electrochemical sensor.5. The sample analysis cartridge of claim 4 , wherein the aPTT sensor is configured to connect with an electrical connector of a test meter.6. The sample analysis cartridge of claim 1 , further comprising a pump configured to:move the biological sample in the conduit and position the biological sample over the PT sensor; andmove the biological sample in the conduit and position the biological sample over the aPTT sensor.7. The sample analysis cartridge of claim 1 , further comprising a closable sample entry port for ...

SINGLE CHANNEL CARTRIDGE DEVICE FOR COAGULATION ASSAYS IN FLUID SAMPLES

The present invention relates to analytical testing devices comprising a single channel with micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using a single channel with micro-environment sensors in a point of care test cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample and a conduit fluidically connected to the inlet chamber. The conduit includes a sensor chip including a first micro-environment sensor and a second microenvironment sensor, and a fluid lock valve. The sample analysis cartridge further includes a pump configured to push the biological sample over the first micro-environment sensor and the second microenvironment sensor to the fluidic lock valve such that the biological sample is positioned over the first micro-environment sensor and the second micro-environment sensor. 1. A sample analysis cartridge comprising:an inlet chamber configured to receive a biological sample; a sensor chip including a first micro-environment sensor and a second microenvironment sensor, and', 'a fluidic lock valve; and, 'a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber, the conduit comprisinga pump configured to push the biological sample over the first micro-environment sensor and the second microenvironment sensor to the fluidic lock valve such that the biological sample is positioned over the first micro-environment sensor and the second micro-environment sensor.2. The sample analysis cartridge of claim 1 , wherein the first micro-environment sensor is a prothrombin time (PT) sensor claim 1 , and the second micro-environment sensor is an activated partial thromboplastin time (aPTT) sensor.3. The sample analysis cartridge of claim 1 , wherein the fluidic lock valve ...

Microfluidic System Including Cooling Device

A microfluidic system for separating biological entities includes a cooling device including a thermoelectric heat pump, a first fan, and a first heat exchanger disposed between the first fan and the thermoelectric heat pump; a first housing structure having a first shell that encases the first fan and the first heat exchanger; a microfluidic device and one or more piezoelectric transducers attached thereto; and a second housing structure reversibly attached to the first housing structure and having a second shell that encloses therein the microfluidic device and the one or more piezoelectric transducers. When the first and second housing structures are coupled, a first air passage is formed between a side of the first heat exchanger and an end of the microfluidic device, a second air passage is formed between the first fan and the piezoelectric transducers, thereby allowing air to circulate between the first and second air passages.

APPARATUS FOR MAINTAINING LIQUID MEMBRANE AND CHEMICAL SENSOR

According to one embodiment, an apparatus for maintaining a liquid membrane includes a liquid supply mechanism which supplies a liquid to the liquid membrane for wetting a biological substance and a liquid discharge mechanism which discharges the liquid in the liquid membrane. 1. An apparatus for maintaining a liquid membrane , comprising:a liquid supply mechanism configured to supply a liquid to the liquid membrane for wetting a biological substance; anda liquid discharge mechanism configured to discharge the liquid in the liquid membrane.2. The apparatus of claim 1 , wherein the liquid supply mechanism includes a first container configured to accommodate a liquid therein and a liquid supply member configured to supply the liquid to the liquid membrane by using a capillary phenomenon.3. The apparatus of claim 2 , wherein the liquid supply member is a capillary having an end inserted into the first container and the other end disposed to be in contact with the liquid membrane.4. The apparatus of claim 2 , wherein the liquid supply member is a nonwoven fabric having an end inserted into the first container and the other end disposed to be in contact with the liquid membrane.5. The apparatus of claim 1 , wherein the liquid discharge mechanism includes a second container configured to collect a discharged liquid and an absorption member having an end inserted into the second container and the other end disposed to be in contact with the liquid membrane claim 1 , and absorbs and discharges the liquid in the liquid membrane by using the absorption member.6. The apparatus of claim 1 , wherein the apparatus for maintaining the liquid membrane maintains the liquid membrane to a thickness of 0.5 μm to 10.0 μm.7. The apparatus of claim 1 , further comprising an oil membrane disposed on a surface of the liquid membrane.8. The apparatus of claim 1 , wherein the biological substance is a receptor.9. The apparatus of claim 1 , wherein the biological substance binds to a target ...

DEVICE FOR STORING AND TRANSPORTING TISSUE SPECIMENS

A container comprising: 1. A container comprising:a first panel;a second panel opposing the first panel;a first side;a second side opposing the first side;a third side;a fourth side opposing the third side;wherein each of the sides joins the first panel and the second panel;a chamber defined by the four sides, the first panel, and the second panel, wherein the chamber is configured to receive a biological specimen;a port defined in the first side;a plug inserted into the port;an opening defined in the second side; anda closure element coupled to the opening,wherein the chamber is leak proof.2. The container of claim 1 , wherein at least one of the first panel or the second panel is transparent.3. The container of claim 1 , wherein both the first panel and the second panel are transparent.4. The container of claim 1 , wherein the closure element is perforated with at least one hole that communicates with the opening in the second side.5. The container of claim 1 , wherein the closure element is removably coupled to the opening of the second side.6. The container of claim 1 , wherein the container is in the shape of a rectangular cuboid.7. The container of claim 1 , wherein the second side includes a ridge aligned along the periphery of the opening claim 1 , and the closure element is a cap removably coupled to the ridge.8. The container of claim 1 , wherein the port is circular and the opening is rectangular.9. The container of claim 1 , wherein a medium resides within the chamber.10. The container of claim 1 , wherein the chamber includes rounded corner walls.11. The container of claim 1 , wherein the chamber has a curvilinear peripheral wall.12. A container in the shape of a rectangular cuboid comprising:a transparent first panel;a transparent second panel opposing the first panel;a first side;a second side opposing the first side;a third side;a fourth side opposing the third side;wherein each of the sides joins the first panel and the second panel;a chamber ...

DEVICE FOR STORING, INCUBATING OR MANIPULATING BIOLOGICAL SAMPLES AND METHOD FOR MOUNTING A HOLDER WITH A UV LIGHT SOURCE TO AN IRRADIATION CHAMBER OF SUCH DEVICE

A device for storing, incubating or manipulating biological samples, in particular incubating device or shaking device, comprising a sample chamber, an irradiation chamber, and a holder with a UV light source, wherein a sidewall of the irradiation chamber comprises a first mounting member and wherein the holder comprises a second mounting member configured to interact with the first mounting member for pre-mounting the holder to the sidewall. 1. A device for storing , incubating or manipulating biological samples , in particular incubating device or shaking device , comprising a sample chamber , an irradiation chamber , and a holder with a UV light source , wherein a sidewall of the irradiation chamber comprises a first mounting member and wherein the holder comprises a second mounting member configured to interact with the first mounting member for pre-mounting the holder to the sidewall.2. The device of claim 1 , wherein the first mounting member and the second mounting member are configured for final mounting claim 1 , in particular for fixing and immobilizing claim 1 , the holder to the sidewall.3. The device of claim 1 , wherein the holder is mountable and/or mounted to an outer face of the sidewall of the irradiation chamber.4. The device of claim 1 , wherein the holder is a box.5. The device of claim 1 , wherein the holder is thermally insulated.6. The device of claim 1 , wherein the first mounting member is a stud claim 1 , in particular a pin claim 1 , a peg or a standoff claim 1 , and wherein the second mounting member is an aperture for receiving the stud.7. The device of claim 6 , wherein the stud comprises a protrusion claim 6 , preferably a head claim 6 , configured to engage behind at least a section of a boundary of the aperture.8. The device of claim 6 , wherein the aperture is a countersunk aperture.9. The device of claim 7 , wherein the section of the boundary of the aperture comprises an inclined plane configured such that a relative movement of ...

REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND METHODS

Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration. 1. A fluidic device comprising:an article comprising a top surface, a bottom surface, a thickness, a first microfluidic channel segment formed in the top surface of the article, and a second microfluidic channel segment formed in the bottom surface of the article;an intervening channel passing through the thickness of the article and connecting the first microfluidic segment formed in the top surface of the article and the second microfluidic channel segment formed in the bottom surface of the article;a first cover positioned over the first microfluidic channel segment on the top surface of the article;a second cover positioned over the second microfluidic channel segment on the bottom surface of the article;an inlet in fluid communication with the first and second microfluidic channel segments;an outlet in fluid communication with the first and second microfluidic channel segments;a third cover covering the inlet; anda fourth cover covering the outlet.2. The fluidic device of claim 1 , comprising a plurality of the first and second ...