СПОСОБ ИЗГОТОВЛЕНИЯ МИКРОФЛЮИДНЫХ УСТРОЙСТВ

1. Способ формирования стеклосодержащего микрофлюидного устройства, имеющего по меньшей мере один флюидный проход через него, причем способ включает в себя: ! обеспечение первой детали из жесткого, антипригарного материала, имеющего профилированную оформляющую поверхность; ! обеспечение первого количества стеклосодержащей композиции; ! осуществление контакта первого количества стеклосодержащей композиции с профилированной оформляющей поверхностью; ! прессование первого количества стеклосодержащей композиции между профилированной оформляющей поверхностью и второй поверхностью; ! нагревание детали из жесткого, антипригарного материала и первого количества стеклосодержащей композиции вместе в достаточной мере, чтобы размягчить количество стеклосодержащей композиции так, что профилированная оформляющая поверхность копируется в первом количестве стеклосодержащей композиции, причем первое количество стеклосодержащей композиции образует первое сформованное стеклосодержащее изделие; и ! герметизацию по меньшей мере части первого сформованного стеклосодержащего изделия для создания микрофлюидного устройства, имеющего по меньшей мере один флюидный проход через него. ! 2. Способ по п.1, в котором вторая поверхность включает в себя поверхность второй детали из жесткого, антипригарного материала. ! 3. Способ по п.1, в котором вторая поверхность включает в себя поверхность подложки, на которой должна быть сформирована стеклосодержащая композиция, причем упомянутый этап нагревания эффективен для прикрепления или присоединения стеклосодержащей композиции к поверхности подложки. ! 4. Способ по п.2, в к� РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2009 135 805 (13) A (51) МПК C03B 23/203 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2009135805/03, 27.02.2008 (71) Заявитель(и): КОРНИНГ ИНКОРПОРЕЙТЕД (US) Приоритет(ы): (30) Конвенционный приоритет: 28.02.2007 EP 07300835.1 (87) Публикация заявки РСТ: WO 2008 ...

CARRIER FOR MICRO FLUID SYSTEM AND MANUFACTURING PROCESS FOR IT

CARRIER UNIT FOR A MICRO-FLUID SYSTEM

CARRIER UNIT FOR A MICRO-FLUID SYSTEM

PROCESSES FOR RAPID MICROFABRICATION USING THERMOPLASTICS AND DEVICES THEREOF

A method is provided to prepare one or more microfluidic channels on a receptive material by applying an image-forming material to a heat sensitive thermoplastic receptive material in a designed pattern and heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%. In an alternative aspect, the microfluidic channels on receptive material are prepared by etching a designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%.

A MANUFACTURING METHOD OF A MICROCHEMICAL CHIP MADE OF A RESIN AND A MICROCHEMICAL CHIP MADE OF A RESIN BY THE METHOD

A manufacturing method of a microchemical chip made of a resin and having a micro channel, which comprises forming a photoresist film over the surface of one side of a metal support substratum, stacking a photomask for the formation of a channel pattern over the photoresist film, forming a minute-structure photoresist pattern over the metal support substratum by a photofabrication technology as a flat-sheet mold, disposing the flat-sheet mold or unit mold obtained by separating the flat-sheet mold on the bottom of a contour forming frame for resin molding, pouring a resin into the contour forming frame for resin molding and curing the resin to form a resin structure having a micro channel formed by the mold, and attaching the resin structure having a micro channel to a flat sheet to be a lid of the micro channel; and microchemical chips manufactured by this method.

METHOD FOR THE FABRICATION OF MICROCHANNELS RECONFIGURABLE

MICROFLUIDIC DEVICE COMPRISING TWO SUBSTRATES WHICH ARE BONDED WITH EACH OTHER AND A METHOD FOR FABRICATING THE SAME

미세유동장치와, 상기 미세유동장치의 제조방법이 개시된다. 개시된 미세유동장치는 서로 마주보게 접합된 상부 및 하부 기판을 포함하는 플랫폼; 상기 하부 기판에 그루브(groove)에 의해 형성된 미세유동 구조물; 상기 미세유동 구조물의 외곽을 따라 상기 하부 기판에서 상기 상부 기판을 향해 돌출 형성된 구조물 외곽 돌출부를 포함하는 하부 기판 돌출 패턴; 및, 상기 상부 및 하부 기판을 접합하기 위하여 상기 하부 기판 돌출 패턴과 상기 상부 기판 사이에 개재되는 접착제층;을 구비하고, 상기 하부 기판 돌출 패턴만이 상기 상부 기판을 지지하고, 상기 하부 기판 돌출 패턴을 제외한 하부 기판의 다른 영역에는 상기 상부 기판을 지지할 수 있는 구조물이 없다.

MICRO FLUID SYSTEM SUPPORT UNIT AND MANUFACTURING METHOD THEREOF

A micro fluid system support unit includes a first support body (2), a first adhesive layer (1a) arranged on the surface of the first support body (2), a first hollow filament group consisting of a plurality of hollow filaments (501 to 508) arranged with an arbitrary shape on the surface of the first adhesive layer (1a), a second hollow filament group consisting of a plurality of hollow filaments (511 to 518) arranged in the direction orthogonal to the first hollow filament group, a second adhesive layer (1b) arranged on the surface of the second hollow filament group, and a second support body (6) arranged on the surface of the second adhesive layer (1b). The first and the second hollow filament group constitute a flow passage layer. COPYRIGHT KIPO & WIPO 2010 ...

Micro fluid chip

The invention relates to a micro fluid chip that leads liquids supplied from a plurality of liquid supply ports, respectively, to a minute flow passage, performs mixing and reaction (chemical reaction) of the liquids in the minute flow passage, and obtains a liquid having been processed from a liquid discharge port. A micro fluid chip 1 that leads liquids supplied from a plurality of liquid supply ports, respectively, to a minute flow passage, performs mixing/reaction of the liquids in the minute flow passage 16, and obtains a liquid having been processed from a liquid discharge port 17, the micro fluid chip including liquid supplies 11, 13 that supply a plurality of flows, which are formed by division of two kinds of liquids, respectively, in an alternate arrangement, and a flow flattening portion 15 provided downstream of the liquid supplies to be configured in flow passage such that liquids alternately arranged are decreased in dimension as they go downstream and increased in dimension ...

Micro fluid system support unit and manufacturing method thereof

A micro fluid system support unit in accordance with the present invention includes a first support body (2), a first adhesive layer (1a) arranged on the surface of the first support body (2), a first hollow filament group consisting of a plurality of hollow filaments (501-508) arranged with an arbitrary shape on the surface of the first adhesive layer (1a), a second hollow filament group consisting of a plurality of hollow filaments (511-518) arranged in the direction orthogonal to the first hollow filament group, a second adhesive layer (1b) arranged on the surface of the second hollow filament group, and a second support body (6) arranged on the surface of the second adhesive layer (1b). The first and the second hollow filament group constitute a flow passage layer.

MICRO-NANO FLUIDIC BIOCHIP FOR ASSAYING BIOLOGICAL SAMPLE

Disclosed is a micro-nano fluidic biochip for assaying a biological sample comprising a first substrate, a second substrate and a third substrate which are sequentially stacked from bottom to top, wherein an upper channel assembly disposed on the second substrate is coupled with the lower channel assembly provided on the first substrate, to form a microfluidic channel, and the microfluidic channel has nano interstices formed at both sides thereof, the nano interstices having a height less than that of the center of the channel.

FLUIDIC MODULE FABRICATION WITH HETEROGENEOUS CHANNEL-FORMING LAMINATES

A method is provided for fabricating a fluidic module (80) comprising fluidic channels (60) defined within a glass or glass-ceramic structure. According to the method, a heterogeneous channel-forming laminate (10) is provided comprising a mold-engaging layer (20) and a laminate backbone (30). The laminate backbone (30) comprises a vitreous body defining a supportive viscosity µB. A channel-forming mold (50) is pressed into engagement with the mold-engaging layer (20) of the channel forming laminate (10) at a molding temperature TM to form fluidic channel components (40) in the channel-forming laminate (10). The molding viscosity µM of the mold-engaging layer (20) is less than the supportive viscosity µB of the laminate backbone (30) at the molding temperature TM. The pressed channel-forming laminate (10') is stacked with a plurality of complementary pressed channel forming laminates (10') to define a plurality of fluidic channels (60) in a stacked laminate structure (70). The plurality ...

MICRO-DEVICE ON GLASS

A method of fabricating a micro-device having micro-features on glass is presented. The method includes the steps of preparing a first glass substrate, fabricating a metallic pattern on the first glass substrate, preparing a second glass substrate and providing one or more apertures on the second glass substrate, heating the first glass substrate and the second glass substrate with a controlled temperature raise, bonding the first glass substrate and the second glass substrate by applying pressure to form a bonded substrate, wherein the metallic pattern is embedded within the bonded substrate, cooling the bonded substrate with a controlled temperature drop and thereafter maintaining the bonded substrate at a temperature suitable for etching, etching the metallic pattern within the bonded substrate, wherein an etchant has access to the metallic pattern via the apertures, forming a void within the bonded substrate, wherein the void comprises micro-features.

Micro fluid system support and manufacturing method thereof

A support unit for a microfluidic system includes a first support; a first adhesive layer provided on a surface of the first support; and a hollow filament laid on a surface of the first adhesive layer to have an arbitrary shape and functioning as a flow channel layer of the microfluidic system.

Microfluidic device with multi-level, programmable microfluidic node

The invention is directed to a microfluidic device, which comprises distinct, parallel levels, including a first level and a second level. It further includes: a first microchannel, a second microchannel, and a node. This node comprises: an inlet port, a cavity, a via, and an outlet port. The cavity is formed on the first level and is open on a top side. The inlet port is defined on the first level; it branches from the first microchannel and communicates with the cavity through an ingress thereof. The outlet port, branches to the second microchannel on the second level. The via extends from the bottom side of the cavity, down to the outlet port, so the cavity may communicate with the outlet port. In addition, the cavity comprises a liquid blocking element to prevent an aqueous liquid filling the inlet port to reach the outlet port.

Method to taylor mechanical properties on MEMS devices and nano-devices with multiple layer photoimageable dry film

A three-dimensional (“3D”) structure for handling fluids, a fluid handling device containing the 3D structure, and a method of making the 3D structure. The method includes providing a composite photoresist material that includes: (a) a first photoresist layer derived from a photoresist resin having a first chemical property selected from the group consisting of epoxide equivalent weight, aromatic content, and crosslink density and (b) at least a second photoresist layer derived from a photoresist resin having a second chemical property selected from the group consisting of epoxide equivalent weight, aromatic content, and crosslink density different from the first chemical property. The composite photoresist material is devoid of an adhesion promotion layer between layers of the composite photoresist material and the composite photoresist material has varying mechanical and/or physical properties through a thickness of the 3D structure.

Method of reducing temperature difference between a pair of substrates and fluid reaction device using the same

A fluid reaction device includes a microfluidic reaction chip which accommodates a fluid, a heater, and a heat transfer facilitating layer which is interposed between the microfluidic reaction chip and the heater, the heat transfer facilitating layer has a higher thermal conductivity than air and can hold particles, wherein formation of an air layer can be prevented.

Microfluidic mixing

A microfluidic device (100) for mixing a liquid L is provided. The microfluidic device (100) comprises a microfluidic chamber (20), having an inlet (30), and arranged to receive the liquid L therein. In use, the microfluidic device (100) is arranged to control translation through the liquid L of a body B introduced therein, wherein the translation of the body B is due to a potential field acting on the body. In this way, the controlled translation of the body B mixes the liquid L in the microfluidic chamber (20).

MICRO CONTAINER FOR MICROSPHERES AND PROCEDURE FOR ITS PRODUCTION

PROCEDURE FOR THE PRODUCTION OF MICRO-FLUID DEVICES

Processes for rapid microfabrication using thermoplastics and devices thereof

Liquid handling device

MICRO FLUID SYSTEM SUPPORT UNIT AND MANUFACTURING METHOD THEREOF

MICORO-NANO FLUIDIC BIOCHIP FOR ASSAYING BIOMASS

본 발명은 생체 시료 분석용 마이크로-나노 플루이딕 바이오칩에 관한 것이다. 특히, 상하 적층된 상부 및 하부 기판, 및 상기 상부 및 하부 기판 사이에 개재된 중간 기판을 포함하며, 이때 상기 하부 기판은 그 상면에, 시료를 수용 및 분리하기 위한 시료 패드, 시료 분석용 시약을 함유하는 시약 패드, 시료 흡수를 위한 흡수 패드, 또는 이들의 조합을 포함하고, 미세유체 채널 형성용 하부 채널 구성부가 형성되어 있으며; 상기 중간 기판은 미세유체 채널 형성용 상부 채널 구성부, 및 하부 기판상에 위치되는 상기 패드들을 고정하기 위한 고정판을 포함하고; 상기 상부 기판은, 중간 기판을 관통하여 하부 기판상의 시료 패드에 시료를 공급하기 위한 시료 투입구, 채널로부터의 시료 분석결과를 도시하는 투시창 및 하부 기판상의 흡수 패드의 유체 흐름을 조절하도록 중간 및 상부 기판을 관통하여 유체 연통되는 벤트홀을 포함하도록 구성되는, 생체 시료 분석용 마이크로-나노 플루이딕 바이오칩으로서, 상기 상부 및 하부 채널 구성부가, 접합되어 미세유체 채널을 형성하고, 이때 상기 미세유체 채널의 좌우 양 측면 모서리부가 미세유체 채널의 중앙부보다 낮은 높이의 나노틈새 형태를 갖도록 형상화된, 생체 시료 분석용 마이크로-나노 플루이딕 바이오칩에 관한 것이다. The present invention relates to a micro-nano fluidic biochip for biological sample analysis. In particular, the upper and lower substrates stacked up and down, and the intermediate substrate interposed between the upper and lower substrates, wherein the lower substrate, the upper surface, a sample pad for receiving and separating the sample, a sample analysis reagent A lower channel component for microfluidic channel formation is formed, including a reagent pad containing, an absorbent pad for sample absorption, or a combination thereof; The intermediate substrate includes an upper channel component for forming a microfluidic channel, and a fixing plate for fixing the pads positioned on the lower substrate; The upper substrate includes a sample inlet for supplying a sample to the sample pad on the lower substrate through the intermediate substrate, a viewing window showing sample analysis results from the channel, and an intermediate and upper substrate to control the fluid flow of the absorption pad on the lower substrate. A micro-nano fluidic biochip for biological sample analysis, which is configured to include a vent hole in fluid communication therethrough, wherein the upper and lower channel components are joined to form a microfluidic channel, wherein the left and right sides of the microfluidic channel The present invention ...

Processo para produção de microcomponentes

CHANNEL AND METHOD OF FORMING CHANNELS

A device is made by forming sacrificial fibers on a substrate mold. The fibers and mold are covered with a first material. The substrate mold is removed, and the covered fibers are then removed to form channels in the first material.

Flexible Microreactors

The present application for patent is in the field of microreactors and more specifically in the field of microreactors which are prepared from flexible substrates. Methods of preparing flexible substrates using various printing methods are also disclosed.

MICROFLUIDIC DEVICE WITH MULTI-LEVEL, PROGRAMMABLE MICROFLUIDIC NODE

The invention is directed to a microfluidic device, which comprises distinct, parallel levels, including a first level and a second level. It further includes: a first microchannel, a second microchannel, and a node. This node comprises: an inlet port, a cavity, a via, and an outlet port. The cavity is formed on the first level and is open on a top side. The inlet port is defined on the first level; it branches from the first microchannel and communicates with the cavity through an ingress thereof. The outlet port, branches to the second microchannel on the second level. The via extends from the bottom side of the cavity, down to the outlet port, so the cavity may communicate with the outlet port. In addition, the cavity comprises a liquid blocking element to prevent an aqueous liquid filling the inlet port to reach the outlet port.

Photostructured chemical devices and methods for making same

A photostructurable ceramic is processed using photostructuring process steps for embedding devices within a photostructurable ceramic volume, the devices may include one or more of chemical, mechanical, electronic, electromagnetic, optical, and acoustic devices, all made in part by creating device material within the ceramic or by disposing a device material through surface ports of the ceramic volume, with the devices being interconnected using internal connections and surface interfaces.

MICRO FLUID SYSTEM SUPPORT AND MANUFACTURING METHOD THEREOF

A support unit for a microfluidic system includes a first support; a first adhesive layer provided on a surface of the first support; and a hollow filament laid on a surface of the first adhesive layer to have an arbitrary shape and functioning as a flow channel layer of the microfluidic system.

Fluidic module fabrication with heterogeneous channel-forming laminates

MICRO FLUID SYSTEM SUPPORT UNIT AND MANUFACTURING METHOD THEREOF

A support unit for a microfluidic system includes a first support; a first adhesive layer provided on a surface of the first support; and a hollow filament laid on a surface of the first adhesive layer to have an arbitrary shape and functioning as a flow channel layer of the microfluidic system.

Method for manufacturing micro-fluidic device for use in lab-on-a-chip (LOC) system, involves melting and welding the materials of lower and upper layers with each other, after cooling below certain temperature

The method involves applying electrically conductive trace (25) on the surface (30) of a lower layer (35). A recess (50) is formed in and/or on an upper layer (40). The two contact points of the trace are made contact with a current source, to carry out the current flow to the trace. The layers are pressed together, such that the trace is arranged between the layers. The materials of the layers along the trace are melted at a material-dependent temperature, and the materials of the layers are welded with each other, after cooling below a certain temperature. An independent claim is included for a micro-fluidic device.

Microfluidic mixing

PROCEDURE FOR MANUFACTURING MICRO CONSTRUCTION UNITS

FUNCTIONAL MATERIALS AND NOVEL METHODS FOR THE FABRICATION OF MICROFLUIDIC DEVICES

The presently disclosed subject matter provides functional perfluoropolyether (PFPE) materials for use in fabricating and utilizing microscale devices, such as a microfluidic device. The functional PFPE materials can be used to adhere layers of PFPE materials to one another or to other substrates to form a microscale device. Further, the presently disclosed subject matter provides a method for functionalizing the interior surface of a microfluidic channel and/or a microtiter well. Also the presently disclosed subject matter provides a method for fabricating a microscale structure through the use of a sacrificial layer of a degradable material.

Support unit for micro fluid system and process for producing the same

The present invention relates to a support unit for a micro fluid system and a process for producing the same. The process for producing the support unit for the micro fluid system at least includes following steps: (ix) filling the varnish in a container; (vi) immersing at least part of at least one hollow filament in the varnish or floating at least one hollow filament on the varnish, (vii) solidifying all or part of the varnish, (x) removing at least a part of the container.

MANUFACTURING PROCESS OF MICROFLUIDICS APPLIED DEVICES MADE OF PLASTICS HAVING REDUCED MANUFACTURING STEPS AND REDUCED MANUFACTURING COSTS AND DEVICES MANUFACTURED THEREFROM HAVING IMPROVED PRECISION

PURPOSE: A manufacturing process of microfluidics applied devices made of plastics and the devices manufactured therefrom are provided to reduce the manufacturing steps, improve precision of the devices, reduce the manufacturing costs, and mass produce the microfluidics applied devices. CONSTITUTION: The manufacturing process of microfluidics applied devices made of plastics comprises the steps of: forming a photoresist film(2) on one side of the metal support substrate(1); accumulating a photomask for forming a channel pattern on the photoresist film(2); forming the microstructure photoresist pattern on the metal support substrate(1) by photo fabrication technique to form a flat board shaped mold; disposing the flat board shaped mold or separated pieces of the flat board shaped mold on the bottom of the appearance mold for shaping plastics; introducing the plastics into the appearance mold for shaping plastics and solidifying it to form a plastic structure having microfluidics; and attaching ...

METHODS FOR FORMING COMPOSITIONS CONTAINING GLASS

Methods for molding glass and glass composites, including providing a first structure having a first surface, providing a second structure having a second surface, the second surface being patterned and porous, and disposing between the first and second surfaces an amount of a composition comprising a glass, then heating together the first and second structures and the first amount of the composition sufficiently to soften the first amount of the composition such that the first and second structures, under gravity or an otherwise applied force, move toward each other, such that the pattern of the second surface is formed into the first amount of the composition, then cooling the composition sufficiently to stabilize it, the second structure comprising porous carbon having an open porosity of at least 5% and wherein the amount of the composition is removable from the second surface, without damage to the amount of the composition or to the second surface, such that the second surface is ...

PHOTOSTRUCTURED CHEMICAL DEVICES AND METHODS FOR MAKING SAME

A photostructurable ceramic is processed using photostructuring process steps for embedding devices within a pholostruclurable ceramic volume, the devices may include one or more of chemical, mechanical, electronic, electromagnetic, optical, and acoustic devices, all made in part by creating device material within the ceramic or by disposing a device material through surface ports of the ceramic volume, with the devices being interconnected using internal connections and surface interfaces.

METHODS AND MATERIALS FOR FABRICATING MICROFLUIDIC DEVICES

Materials and methods are provided for fabricating microfluidic devices. The materials include low surface energy fluoropolymer compositions having multiple cure functional groups. The materials can include multiple photocurable and/or thermal-curable functional groups such that laminate devices can be fabricated. The materials also substantially do not swell in the presence of hydrocarbon solvents.

METHOD FOR PRODUCING MICROCOMPONENTS

Procédé de production de microéléments à une couche unique au moins, qui possèdent des couches fonctionnelles (3) sur les parois de structures internes, par exemple de canaux d'écoulement. Lesdits microéléments sont appropriés pour une pluralité d'applications diverses dans le domaine des réactions chimiques, pour l'échange de chaleur, le mélange de substances ou l'évaporation de liquides. Lesdits microéléments doivent en particulier ne présenter aucun problème concernant l'étanchéité des canaux d'écoulement. Ledit procédé consiste (A) à fabriquer la couche unique au moins par (a) fabrication d'une première couche de métal ou d'un film métallique (1), (b) formation des structures internes dans et/ou sur la première couche de métal ou film métallique (1) par des procédés appropriés d'attaque et/ou d'application de métal et (c) formation des couches fonctionnelles (3) exclusivement sur les parois des structures internes, puis (B) à empiler et à assembler la couche unique avec un segment fermant ...

Systems and methods for mixing reactants

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

Fluidic mixer in microfluidic system

Microfluidic devices capable of efficiently mixing two or more fluid are provided. Two or more microfluidic inlet channels defined in different sheets of material meet at an overlap region in fluid communication with an outlet channel. The channels are defined through the entire thickness of stencil sheets. The overlap region may include an aperture-defining spacer layer, and/or an impedance element, such as a porous membrane, adapted to distribute at least one fluid across the entire width of the outlet channel to promote reliable fluid mixing.

Verfahren zum Herstellen einer mikrofluidischen Vorrichtung und nach dem Verfahren hergestellte Vorrichtung

Verfahren zum Herstellen einer wenigstens aus einer ersten Schicht (35) und einer zweiten Schicht (40) bestehenden mikrofluidischen Vorrichtung (10), die folgenden Schritte umfassend:- Aufbringen von wenigstens einer elektrisch leitenden Leiterbahn (25) auf einer Oberfläche (30) der ersten Schicht (35);- Ausbilden von wenigstens einer Ausnehmung (15) in und/oder auf der zweiten Schicht (40);- Kontaktieren der Leiterbahn (25) an wenigstens zwei Punkten der Leiterbahn (25) mit einer außerhalb der ersten bzw. zweiten Schicht (35, 40) angeordneten Stromquelle, so dass bei Betrieb der Stromquelle ein Stromfluss in der Leiterbahn (25) zustande kommt;- Aufeinanderpressen der ersten und der zweiten Schicht (35, 40), so dass die Leiterbahn (25) zwischen der ersten und der zweiten Schicht (35, 40) angeordnet ist; und- Betreiben der Stromquelle derart, dass während des Aufeinanderpressens der ersten und zweiten Schicht (35, 40) Material beider Schichten (35, 40) entlang der stromdurchflossenen Leiterbahn ...

CARRIER UNIT FOR A MICRO-FLUID SYSTEM

CARRIER UNIT FOR A MICRO-FLUID SYSTEM

Method for producing microcomponents

METHOD FOR MAKING MICROFLUID DEVICES

Described herein are methods for making microfluidic devices comprising g lass or glass-containing materials, wherein the methods have decreased cost and/or improved dimensional properties over similar formed glass articles pr oduced using current techniques. In particular, a first piece of rigid, non- stick material is provided, having a patterned molding surface; a first amou nt of a glass-containing composition is provided; the first amount of glass- containing composition is contacted with the patterned molding surface and p ressed between the patterned molding surface and a second surface; the piece of rigid non-stick material and the first amount of glass-containing compos ition are heated together sufficiently to soften the amount glass-containing composition such that the patterned molding surface is replicated in the fi rst amount of glass-containing composition, forming a formed glass- containi ng article; at least a portion of the formed glass-containing article is sea led to ...

The micro-chip, and micro-chip manufacturing method

METHODS FOR MAKING MICROFLUIDIC DEVICES AND DEVICES PRODUCED THEREOF

Described herein are methods for making microfluidic devices comprising glass or glass-containing materials, wherein the methods have decreased cost and/or improved dimensional properties over similar formed glass articles produced using current techniques. In particular, a first piece of rigid, non-stick material is provided, having a patterned molding surface; a first amount of a glass-containing composition is provided; the first amount of glass-containing composition is contacted with the patterned molding surface and pressed between the patterned molding surface and a second surface; the piece of rigid non-stick material and the first amount of glass-containing composition are heated together sufficiently to soften the amount glass-containing composition such that the patterned molding surface is replicated in the first amount of glass-containing composition, forming a formed glass-containing article; at least a portion of the formed glass-containing article is sealed to create a microfluidic ...

METHOD FOR PRODUCING FINE STRUCTURES IN THE VOLUME OF A SUBSTRATE COMPOSED OF HARD BRITTLE MATERIAL

A method for producing a cavity in a substrate composed of hard brittle material is provided. A laser beam of an ultrashort pulse laser is directed a side surface of the substrate and is concentrated by a focusing optical unit to form an elongated focus in the substrate. Incident energy of the laser beam produces a filament-shaped flaw in a volume of the substrate. The filament-shaped flaw extends into the volume to a predetermined depth and does not pass through the substrate. To produce the filament-shaped flaw, the ultrashort pulse laser radiates in a pulse or a pulse packet having at least two successive laser pulses. After at least two filament-shaped flaws are introduced, the substrate is exposed to an etching medium which removes material of the substrate and widens the at least two filament-shaped flaws to form filaments. At least two filaments are connected to form a cavity.

MICROFLUIDIC CIRCUIT ELEMENT COMPRISING MICROFLUIDIC CHANNEL WITH NANO INTERSTICES AND FABRICATION THEREOF

PURPOSE: A micro-fluidic circuit comprising a micro-fluidic channel with nano interstices and fabrication thereof are provided to have stable flow regardless of processes. CONSTITUTION: A micro-fluidic circuit comprises a micro-fluidic channel(5). A sample inlet and a sample outlet are formed on the top surface of the micro-fluidic circuit. Both edges of the micro-fluidic channel have a nano gap(4) lower a center part thereof. COPYRIGHT KIPO 2010 ...

METHOD FOR PRODUCTION OF DEVICES MICROFLUÍDICOS

MICROREACTOR GLASS DIAPHRAGM SENSORS

Microfluidic devices having wall structures comprised of sintered glass frit and further including a glass, glass-ceramic or ceramic membrane structure sealed by a sintered seal to said wall structures, such that a a fluid passage or chamber is defined at least in part by the wall structures and said membrane structure. This allows for changes in pressure within the fluid passage or chamber to cause deflections of the membrane structure, providing for direct measurement of pressure within the device. The microfluidic device may have both floors and walls of sintered frit, or may have only walls of sintered frit, with planar floor-like substrate structures, thicker than the membrane structure defining the vertical boundaries of the internal passages. The device may include multiple fluid passages or chambers each defined at least in part by a membrane structure. Multiple membrane structures may be used in a single device, and one single membrane structure may be used for multiple passages or chamber.

MICROBEAD-FILLED MICROSYSTEM AND PRODUCTION METHOD THEREOF

The invention relates to a microsystem which is intended to receive beads and to position said beads precisely at determined locations in the microsystem. The inventive microsystem consists of a container (3) comprising a cavity (4) which is equipped with blocking elements (5). According to the invention, the blocking elements are used to arrange and stack the beads in the spaces therebetween, said spaces forming the aforementioned determined locations. The invention also comprises a cover (7) which is hermetically fixed to the container (3) and inlet (8) and outlet (9) means which enable a fluid to flow into the cavity (4). The invention also relates to the production and use of said bead-filled microsystem.

Photostructured electronic devices and methods for making same

A photostructurable ceramic is processed using photostructuring process steps for embedding devices within a photostructurable ceramic volume, the devices may include one or more of chemical, mechanical, electrical, electromagnetic, optical, and acoustic devices, all made in part by creating device material within the ceramic or by disposing a device material through surface ports of the ceramic volume, with the devices being interconnected using internal connections and surface interfaces.

Microfluidic device and method of fabricating the same

A microfluidic device and a method of fabricating the microfluidic device are provided. The microfluidic device includes: a platform including an upper substrate and a lower substrate that are bonded to face each other; a microfluidic structure obtained by forming grooves in the lower substrate; a lower substrate protrusion pattern including an outline protrusion that protrudes from the lower substrate toward the upper substrate along an outline of the microfluidic structure; and an adhesive layer disposed between the lower substrate protrusion pattern and the upper substrate in order to bond the upper substrate and the lower substrate to each other. The lower substrate protrusion pattern only supports the upper substrate, and remaining portions of the lower substrate except for the lower substrate protrusion pattern do not have structures for supporting the upper substrate.

Photostructured chemical devices and methods for making same

A photostructurable ceramic is processed using photostructuring process steps for embedding devices within a photostructurable ceramic volume, the devices may include one or more of chemical, mechanical, electronic, electromagnetic, optical, and acoustic devices, all made in part by creating device material within the ceramic or by disposing a device material through surface ports of the ceramic volume, with the devices being interconnected using internal connections and surface interfaces.

MICROFLUIDIC CHIP, MANUFACTURING METHOD THEREFOR AND ANALYSIS DEVICE USING SAME

According to embodiments of the present invention, a microfluidic chip, a manufacturing method therefor and an analysis device using the same are provided. The microfluidic chip comprises: a substrate comprising an inflow part through which a fluid flows in, a fluid channel through which the fluid moves and an outflow part through which the fluid flows out; and a film attached to the substrate to protect at least one of the inflow part, the outflow part and the fluid channel from the outside, wherein the inflow part and the outflow part are implemented by penetrating through the surface of the substrate, and the fluid channel can be implemented by being sunk from the surface of the substrate.

Process for manufacturing integrated chemical microreactors of semiconductor material

The microreactor is completely integrated and is formed by a semiconductor body having a surface and housing at least one buried channel accessible from the surface of the semiconductor body through two trenches. A heating element extends above the surface over the channel and a resist region extends above the heating element and defines an inlet reservoir and an outlet reservoir. The reservoirs are connected to the trenches and have, in cross-section, a larger area than the trenches. The outlet reservoir has a larger area than the inlet reservoir. A sensing electrode extends above the surface and inside the outlet reservoir.

3D MICROSTRUCTURING FOR GENERATING MIXED STRUCTURES AND CHANNEL STRUCTURES IN MULTILAYER TECHNOLOGY FOR USE IN OR FOR THE CONSTRUCTION OF REACTORS

MANUFACTURING METHOD FOR SMALL-SIZED REACTORS AND SMALL-SIZED REACTORS

A small-sized reactor having practical utility in light of a bonding force, ease in observation, exemption from impurities and high resistance against pressure, is provided. In bonding a plural number of inorganic transparent substrates (11) to (13) to form a small-sized reactor, surfaces for bonding (16) to (19) of the inorganic transparent substrates (11) to (13), bonded on contact to one another, are initially polished and planarized. A part of the surface of each of the surfaces for bonding is then machined. The surfaces for bonding (16) to (19) are then hydrophilicity enhanced and washed with pure water. A film of pure water is swung off and removed by a centrifugal force. The resultant product is then heated with the surfaces for bonding in contact with one another. The surfaces for bonding, in contact with one another, may be bonded together by chemical bonding via oxygen to form small-sized reactors (1), (2) in which the inorganic transparent substrates (11) to (13) are bonded together ...

A support unit for a microfluidic system

A support unit for a microfluidic system includes a first support; a first adhesive layer provided on a surface of the first support; and a hollow filament laid on a surface of the first adhesive layer to have an arbitrary shape and functioning as a flow channel layer of the microfluidic system. A second support maybe provided on the first support and the hollow filament.

Verfahren zur Herstellung von mikrofluidischen Vorrichtungen

Microfluidics package and method of fabricating the same

Microfluidics package and method of fabricating the same

A microfluidics package (1) comprising a substrate (6) having a top surface, said top surface comprises at least one fluid channel (11, 12), at least one fluidic chip (2) having a top surface, a bottom surface, at least one side surface, and at least one passage to allow a fluid to traverse from the top surface or any side surface to the bottom surface of the chip; and a sheet (4) of which both sides are adhesive, wherein the first adhesive side of the sheet (4) is secured to the substrate (6), and the at least one fluidic chip (2) is secured by the second adhesive side of the sheet (4), said fluidic chip (2) being arranged such that the at least one passage of the fluidic chip is in fluid communication with the at least one fluid channel (11,12) of the substrate.

METHOD OF MANUFACTURING MICRO-COMPONENTS

The invention relates to a method for producing microcomponents with at least one individual layer, which has functional layers (3) on the walls of inner structures such as flow channels. The aim of the invention is to produce microcomponents that are suitable for a variety of different applications in chemical reaction engineering, for heat-exchange applications, for mixing substances or for evaporating liquids. In particular, the inventive microcomponents should not present any problems in terms of the tightness of the flow channels. To this end, the inventive method comprises the following steps: A) producing the at least one individual layer by a) producing a first metal layer or metal film (1), b) forming the inner structures in and/or on said first metal layer or metal film (1) using suitable etching techniques and/or metal application techniques, and c) forming the functional layers (3) on the walls of the inner structures only, and then B) stacking and joining the one individual ...

MICRO FLUID SYSTEM SUPPORT UNIT AND MANUFACTURING METHOD THEREOF

A micro fluid system support unit includes a first support body (2), a first adhesive layer (1a) arranged on the surface of the first support body (2), a first hollow filament group consisting of a plurality of hollow filaments (501 to 508) arranged with an arbitrary shape on the surface of the first adhesive layer (1a), a second hollow filament group consisting of a plurality of hollow filaments (511 to 518) arranged in the direction orthogonal to the first hollow filament group, a second adhesive layer (1b) arranged on the surface of the second hollow filament group, and a second support body (6) arranged on the surface of the second adhesive layer (1b). The first and the second hollow filament group constitute a flow passage layer. © KIPO & WIPO 2007 ...

MICRO FLUID SYSTEM SUPPORT UNIT

Method for making microfluidic devices and devices produced thereof

Described herein are methods for making microfluidic devices comprising glass or glass-containing materials, wherein the methods have decreased cost and/or improved dimensional properties over similar formed glass articles produced using current techniques. In Particular, a first piece of rigid, non-stick material is provided, having a patterned molding surface; a first amount of a glass-containing composition is provided; the first amount of glass-containing composition is contacted with the patterned molding surface and Pressed between the patterned molding surface and a second surface; the piece of rigid non-slick material and the first amount glass-containing composition are heated together sufficiently to soften the amount glass-containing composition such that the patterned molding surface is replicated in the first amount of glass-containing composition, forming a formed glass-containing article; at least a portion of the formed glass-containing article is sealed to create a microfluidic ...

3D MICROSTRUCTURING FOR GENERATING MIXED STRUCTURES AND CHANNEL STRUCTURES IN MULTILAYER TECHNOLOGY FOR USE IN OR FOR THE CONSTRUCTION OF REACTORS

The present invention relates to a channel structure for a bioreactor, biochemical reactor, chemical reactor or a reformer comprising a plurality of individual layers (1A, 1B, 1C) stacked on one another and having a respective plurality of openings (3) which pass completely through the respective individual layer and which are characterized in that at least two directly adjacent individual layers each have at least one layer section whose openings are arranged in the form of a pattern (4) respectively regular in two dimensions (D1, D2) and in that at least two of the layer sections provided with such a pattern in this manner of directly adjacent individual layers overlap (5) at least in part, wherein the openings of the two at least partly overlapping layer sections are rotated and/or offset with respect to one another in the overlap region.

Integrated chemical microreactor with large area channels and manufacturing process thereof

The microreactor has a body of semiconductor material; a large area buried channel extending in the body and having walls; a coating layer of insulating material coating the walls of the channel; a diaphragm extending on top of the body and upwardly closing the channel. The diaphragm is formed by a semiconductor layer completely encircling mask portions of insulating material.

マイクロ流路デバイス

Self-limited, anisotropic wet etching of transverse vias in microfluidic chips

Functional materials and novel methods for the fabrication of microfluidic devices

MICROSYSTEM HAS FILLING OF MICROBALLS AND PROCESS Of OBTAINING

NANOWIRE STRUCTURAL ELEMENT

The invention relates to a nanowire structural element suitable for installing, for example, in a microreactor system or microcatalyst system. A template-based method is used for producing the nanowire structural element, wherein electrochemical deposition of the nanowires takes place in nanopores. Irradiation takes place at various angles, so that a nanowire network is formed. The structured hollow space in the nanowire network is exposed by dissolving the template foil and removing the dissolved template material. The networking of the nanowires gives the nanowire structural element stability, and an electrical connection is established between the nanowires.

PROCESS FOR MANUFACTURING RECONFIGURABLE MICROCHANNELS

The invention relates to a microfluidic device, comprising a microfluidic array, comprising: a) two parallel plates (2, 4) each equipped with one or more electrodes (3, 13), b) at least one channel (9), positioned between the two plates, made from a material obtained by solidification or hardening of the material of a first fluid (6), c) means for varying a physical parameter of the constituent material of the walls of the channel in order to change it at least from the liquid state to the solid state.

Processes for rapid microfabrication using thermoplastics and devices thereof

A method is provided to prepare one or more microfluidic channels on a receptive material by applying an image-forming material to a heat sensitive thermoplastic receptive material in a designed pattern and heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%. In an alternative aspect, the microfluidic channels on receptive material are prepared by etching a designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%.

MICROFLUIDIC DEVICE WITH HYDROPHOBIC SURFACE MODIFICATION LAYER AND MANUFACTURING METHOD THEREOF

A microfluidic device includes a support body having a first surface and a second surface opposite to one another. The first surface is hydrophilic. A surface modification layer extends over the first surface of the support body. At least one opening is formed to extend through the surface modification layer and expose a portion of the first surface. The surface modification layer is hydrophobic. In particular, the surface modification layer is made of a photodefinible material chosen from among: an epoxy resin, a polyamide, and a photocurable siloxane-based polymer. The openings are functionalized using probe molecules designed to bind with specific target molecules to be detected.

Catalyst for microelectromechanical systems microreactors

A microreactor comprising a silicon wafer, a multiplicity of microchannels in the silicon wafer, and a catalyst coating the microchannels. In one embodiment the catalyst coating the microchannels comprises a nanostructured material. In another embodiment the catalyst coating the microchannels comprises an aerogel. In another embodiment the catalyst coating the microchannels comprises a solgel. In another embodiment the catalyst coating the microchannels comprises carbon nanotubes.

A manufacturing method of a microchemical chip made of a resin and a microchemical chip made of a resin by the method

Method for making microfluidic devices

Described herein are methods for making microfluidic devices comprising glass or glass-containing materials, wherein the methods have decreased cost and/or improved dimensional properties over similar formed glass articles produced using current techniques.

Method of reducing temperature difference between a pair of substrates and fluid reaction device using the same

MICROFLUIDIC CIRCUIT ELEMENT COMPRISING MICROFLUIDIC CHANNEL WITH NANO INTERSTICES AND FABRICATION THEREOF

Bead packing in microfluidic channels

METHODS FOR FORMING COMPOSITIONS CONTAINING GLASS

Methods for molding glass and glass composites, including providing a first structure having a first surface, providing a second structure having a second surface, the second surface being patterned and porous, and disposing between the first and second surfaces an amount of a composition comprising a glass, then heating together the first and second structures and the first amount of the composition sufficiently to soften the first amount of the composition such that the first and second structures, under gravity or an otherwise applied force, move toward each other, such that the pattern of the second surface is formed into the first amount of the composition, then cooling the composition sufficiently to stabilize it, the second structure comprising porous carbon having an open porosity of at least 5% and wherein the amount of the composition is removable from the second surface, without damage to the amount of the composition or to the second surface, such that the second surface is ...

METHOD OF REDUCING TEMPERATURE DIFFERENCE BETWEEN A PAIR OF SUBSTRATES AND FLUID REACTION DEVICE USING THE SAME

A method of reducing a temperature difference between a high-temperature and a low-temperature substrate includes interposing a heat transfer facilitating layer which has a higher thermal conductivity than air and can hold particles between the substrates, and maintaining close contact between the high-temperature substrate, the heat transfer facilitating layer, and the low-temperature substrate, wherein formation of an air layer can be at least substantially prevented between the high-temperature substrate and the heat transfer facilitating layer, and between the low-temperature substrate and the heat transfer facilitating layer. A fluid reaction device includes a microfluidic reaction chip which accommodates a fluid, a heater, and a heat transfer facilitating layer which is interposed between the microfluidic reaction chip and the heater, the heat transfer facilitating layer has a higher thermal conductivity than air and can hold particles, wherein formation of an air layer can be prevented ...

METHODS FOR FORMING COMPOSITIONS CONTAINING GLASS

Methods for molding glass and glass composites, including providing a first structure having a first surface, providing a second structure having a second surface, the second surface being patterned and porous, and disposing between the first and second surfaces an amount of a composition comprising a glass, then heating together the first and second structures and the first amount of the composition sufficiently to soften the first amount of the composition such that the first and second structures, under gravity or an otherwise applied force, move toward each other, such that the pattern of the second surface is formed into the first amount of the composition, then cooling the composition sufficiently to stabilize it, the second structure comprising porous carbon having an open porosity of at least 5% and wherein the amount of the composition is removable from the second surface, without damage to the amount of the composition or to the second surface, such that the second surface is ...

MICRO FLUID SYSTEM SUPPORT AND MANUFACTURING METHOD THEREOF

A support unit for a microfluidic system includes a first support; a first adhesive layer provided on a surface of the first support; and a hollow filament laid on a surface of the first adhesive layer to have an arbitrary shape and functioning as a flow channel layer of the microfluidic system.

METHOD FOR PRODUCING A STAMP FOR HOT EMBOSSING

The present invention provides a process for producing a stamp for hot embossing (HE). The stamp can be constructed from any photo-resist epoxy that is stable at temperatures equal to the glass transition temperature (T g) of the material to be stamped. The stamp can be used repeatedly without significant distortion of features. The stamp benefits from low relative cost, high fidelity of features in all three-dimensions and fast construction. The process for producing a stamp for hot embossing from a resist, comprising the steps of producing a seed layer L1 from a selected photoresist polymer material, soft baking the seed layer L1, exposing said seed layer L1 to initiate cross-linking and then post-exposure bake L1 to fully cross-link it, coating the cross-linked seed layer L1 with a second photoresist polymer layer L2; soft baking the second photoresist polymer layer L2; applying a mask to the top surface of the soft baked layer L2 and illuminating the unmasked portions of the soft baked layer L2 with UV radiation through the mask, wherein the exposed areas form the pattern of the embossing features, washing away unexposed regions of the photoresist with a developer to leave behind a relief pattern formed in the second photoresist polymer layer L2, which relief pattern corresponds to a pattern in the mask.

Transmission of pressure to micro-membrane e.g. for electronic Braille book uses electrical activation of liquid droplet to modify contact with hydrophobic surface

A device for transmitting pressure to a micro-membrane (22), comprising a liquid droplet (30) on an electrically insulating and hydrophobic surface of a supporting substrate (10), comprises a plate (20) with an aperture (21) covered by the micro-membrane to hold the micro-membrane in contact with the droplet, and an electrical activator in the form of a disc electrode (12) and a wire (17) to modify the line of contact between the droplet and the hydrophobic surface. The droplet is positioned by a star-shaped electrode (14) within the supporting substrate and located concentrically with the wire that delivers a centering electrical potential.

Method for realizing buried microfluidic channel integrated structure that is utilized for e.g. microelectromechanic system, involves smoothening walls of microfluidic channel, after forming channel before gluing plates

The method involves forming a microfluidic channel (110) on a face of a semiconductor material plate, and gluing another plate on the face of the former plate, where the semiconductor material is chosen from silicon, germanium silicon or germanium. Walls of the microfluidic channel are smoothened, after forming the channel before gluing the plates. The former plate is annealed under controlled air containing gas chosen from argon, hydrogen and nitrogen. An independent claim is also included for a buried microfluidic channel integrated component comprising a semi-conductor material layer.

METHOD FOR THE FABRICATION OF MICROCHANNELS RECONFIGURABLE

L'invention concerne un dispositif microfluidique, comportant un réseau microfluidique, comportant:a) deux plaques (2, 4) parallèles chacune munie d'une ou plusieurs électrodes (3, 13),b) au moins un canal (9), disposé entre les deux plaques, en un matériau obtenu par solidification ou durcissement du matériau d'un premier fluide (6),c) des moyens pour faire varier un paramètre physique du matériau constitutif des parois du canal afin de le faire passer au moins de l'état liquide à l'état solide. The invention relates to a microfluidic device, comprising a microfluidic network, comprising: a) two parallel plates (2, 4) each provided with one or more electrodes (3, 13), b) at least one channel (9), arranged between the two plates, in a material obtained by solidification or hardening of the material of a first fluid (6), c) means for varying a physical parameter of the material constituting the walls of the channel in order to make it pass at least 1 liquid state in the solid state.

METHOD FOR PRODUCING A STAMP FOR HOT EMBOSSING

The present invention provides a process for producing a stamp for hot embossing (HE). The stamp can be constructed from any photo-resist epoxy that is stable at temperatures equal to the glass transition temperature (Tg) of the material to be stamped. The stamp can be used repeatedly without significant distortion of features. The stamp benefits from low relative cost, high fidelity of features in all three-dimensions and fast construction. The process for producing a stamp for hot embossing from a resist, comprising the steps of producing a seed layer L1 from a selected photoresist polymer material, soft baking the seed layer L1, exposing said seed layer L1 to initiate cross-linking and then post-exposure bake L1 to fully cross-link it, coating the cross-linked seed layer L1 with a second photoresist polymer layer L2; soft baking the second photoresist polymer layer L2; applying a mask to the top surface of the soft baked layer L2 and illuminating the unmasked portions of the soft baked ...

MICROFLUIDIC CIRCUIT ELEMENT COMPRISING MICROFLUIDIC CHANNEL WITH NANO INTERSTICES AND FABRICATION METHOD THEREOF

A microfluidic circuit element comprising a microfluidic channel, in which the microfluidic channel has nano interstices formed at both sides thereof and having a height less than that of the center of the channel, gives more driving force of the microfluidic channel and provides stable flow of a fluid.

MICRO FLUID SYSTEM SUPPORT AND MANUFACTURING METHOD THEREOF

A support unit for a microfluidic system includes a first support; a first adhesive layer provided on a surface of the first support; and a hollow filament laid on a surface of the first adhesive layer to have an arbitrary shape and functioning as a flow channel layer of the microfluidic system.

Method for producing a stamp for hot embossing

The present invention provides a process for producing a stamp for hot embossing (HE). The stamp can be constructed from any photo-resist epoxy that is stable at temperatures equal to the glass transition temperature (T g ) of the material to be stamped. The stamp can be used repeatedly without significant distortion of features. The stamp benefits from low relative cost, high fidelity of features in all three-dimensions and fast construction. The process for producing a stamp for hot embossing from a resist, comprising the steps of producing a seed layer L 1 from a selected photoresist polymer material, soft baking the seed layer L 1 , exposing said seed layer L 1 to initiate cross-linking and then post-exposure bake L 1 to fully cross-link it, coating the cross-linked seed layer L 1 with a second photoresist polymer layer L 2 ; soft baking the second photoresist polymer layer L 2 ; applying a mask to the top surface of the soft baked layer L 2 and illuminating the unmasked portions of the soft baked layer L 2 with UV radiation through the mask, wherein the exposed areas form the pattern of the embossing features, washing away un-exposed regions of the photoresist with a developer to leave behind a relief pattern formed in the second photoresist polymer layer L 2 , which relief pattern corresponds to a pattern in the mask.

Channel and method of forming channels

A device is made by forming sacrificial fibers on a substrate mold. The fibers and mold are covered with a first material. The substrate mold is removed, and the covered fibers are then removed to form channels in the first material.

Device and method for manufacturing the same

It is an object of this invention to prevent a resistor material and an electrode material from diffusing and suppress variation in electric resistance. In a device including a plurality of metal layers of different compositions on a substrate and a second structure made of a material, such as glass paste, requiring a firing process at the time of formation, an intermediate layer is formed between a first metal layer and a second metal layer forming the first structure. The intermediate layer is of an intermetallic compound including one or more metallic elements in the first metal layer and one or more metallic elements in the second metal layer. The melting point of the intermetallic compound is higher than a firing temperature when the second structure is formed, and the intermetallic compound is produced at a temperature higher than the firing temperature for forming the second structure.

Microfluidic component, reactor comprising a plurality of such components, and method for producing same

A microfluidic component made of a metal sheet having a structure which includes a closed fluid line and which is formed of a structured surface of a first section of the metal sheet and an adjoining structured or unstructured surface of a second section of the metal sheet, wherein the metal sheet is folded such that the sections integrally connected to each other are located on top of each other in a surface-parallel manner. The metal sheet further includes at least one third section having a contoured edge and is moreover folded such that the third section is also supported in a surface-parallel manner and the contoured edge forms a first wall section and the adjoining structured or unstructured surface of the first or second section forms a second wall section of an open fluid line. A microfluidic reactor comprising a plurality of such microfluidic components and a method for producing such components.

INERTIAL PUMPS

The present disclosure is drawn to inertial pumps. An inertial pump can include a microfluidic channel, a fluid actuator located in the microfluidic channel, and a check valve located in the microfluidic channel. The check valve can include a moveable valve element, a narrowed channel segment located upstream of the moveable valve element, and a blocking element formed in the microfluidic channel downstream of the moveable valve element. The narrowed channel segment can have a width less than a width of the moveable valve element so that the moveable valve element can block fluid flow through the check valve when the moveable valve element is positioned in the narrowed channel segment. The blocking element can be configured such that the blocking element constrains the moveable valve element within the check valve while also allowing fluid flow when the moveable valve element is positioned against the blocking element. 1. An inertial pump , comprising:a microfluidic channel;a fluid actuator located in the microfluidic channel; and a moveable valve element,', 'a narrowed channel segment located upstream of the moveable valve element, the narrowed channel segment having a width less than a width of the moveable valve element such that the moveable valve element blocks fluid flow through the check valve when the moveable valve element is positioned in the narrowed channel segment, and', 'a blocking element formed in the microfluidic channel downstream of the moveable valve element and configured such that the blocking element constrains the moveable valve element within the check valve while also allowing fluid flow when the moveable valve element is positioned against the blocking element., 'a check valve located in the microfluidic channel, the check valve comprising2. The inertial pump of claim 1 , wherein the fluid actuator is a resistor configured to generate vapor bubbles to displace fluid in the microfluidic channel.3. The inertial pump of claim 1 , wherein the ...

EPITAXIAL-SILICON WAFER WITH A BURIED OXIDE LAYER

Examples of an epitaxial-silicon wafer with a buried oxide layer are described herein. Examples of methods to manufacture an epitaxial-silicon wafer with a buried oxide layer are also described herein. In some examples, material may be removed from an epitaxial-silicon wafer at a surface opposite an epitaxial surface layer until the epitaxial-silicon wafer is a specified thickness. The thinned epitaxial-silicon wafer may be bonded to an oxidized-silicon wafer at an oxidized surface forming a buried oxide layer. 1. A method , comprising:removing material from an epitaxial-silicon wafer at a surface opposite an epitaxial surface layer until the epitaxial-silicon wafer is a specified thickness; andbonding the thinned epitaxial-silicon wafer to an oxidized-silicon wafer at an oxidized surface forming a buried oxide layer.2. The method of claim 1 , wherein removing the material from the epitaxial-silicon wafer comprises grinding the surface opposite the epitaxial surface layer until the epitaxial-silicon wafer is the specified thickness.3. The method of claim 1 , wherein bonding the thinned epitaxial-silicon wafer to the oxidized-silicon wafer comprises a low-temperature bond.4. The method of claim 3 , wherein the low-temperature bond comprises an adhesive bond.5. The method of claim 1 , wherein the epitaxial-silicon wafer comprises a heavily doped silicon substrate and a lightly doped epitaxial surface layer.6. The method of claim 1 , wherein the oxidized-silicon wafer comprises a lightly doped silicon substrate with the oxidized surface.7. A method claim 1 , comprising:attaching an epitaxial surface layer of a epitaxial-silicon wafer to a handle wafer;grinding a surface opposite the epitaxial surface layer until the epitaxial-silicon wafer is a specified thickness;polishing the surface opposite the epitaxial surface layer;removing the thinned epitaxial-silicon wafer from the handle wafer; andbonding the thinned epitaxial-silicon wafer to an oxidized-silicon wafer at an ...

PROCESSES FOR RAPID MICROFABRICATION USING THERMOPLASTICS AND DEVICES THEREOF

A method is provided to prepare one or more microfluidic channels on a receptive material by applying an image-forming material to a heat sensitive thermoplastic receptive material in a designed pattern and heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%. In an alternative aspect, the microfluidic channels on receptive material are prepared by etching a designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%. 157.-. (canceled)58. A device comprising a heat-shrunk thermoplastic base having a textured metal surface , wherein the textured metal surface has an average height from about 100 nanometers to about 5 micrometers.59. The device of claim 58 , wherein the textured metal surface comprises at least one metal selected from the group consisting of silver claim 58 , gold and copper.60. A method to prepare one or more microfluidic channels on a receptive material claim 58 , comprising the steps of:a) applying an image-forming material to a heat sensitive thermoplastic receptive material in a designed pattern;b) heating said material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%; andc) preparing the microfluidic channels via lithography.61. The method according to claim 60 , wherein the image-forming material is a liquid containing one or more of the group of pigment claim 60 , dye claim 60 , or combination thereof.62. The method according to claim 60 , wherein the image-forming material is one or more of the group of an ink claim 60 , a protein claim 60 , a colloid claim 60 , a dielectric material claim 60 , a paste claim 60 , or a combination thereof.63. The method according to claim 60 , wherein the image-forming material is a metal.64. The method according to claim 63 , wherein the metal is one or ...

Microfluidic mixing

A microfluidic device (100) for mixing a liquid L is provided. The microfluidic device (100) comprises a microfluidic chamber (20), having an inlet (30), and arranged to receive the liquid L therein. In use, the microfluidic device (100) is arranged to control translation through the liquid L of a body B introduced therein, wherein the translation of the body B is due to a potential field acting on the body. In this way, the controlled translation of the body B mixes the liquid L in the microfluidic chamber (20).

Method for forming micro channels in molded components and an associated micro-channel forming tool

A method of forming micro-channels in a plastic surface using a pressing device includes structuring a micro-channel forming tool for the pressing device to include a press end including a press surface that extends along a plane and a micro-channel detail positioned on the press end and extending beyond the plane of the press surface. The micro-channel detail includes a non-critical portion and a critical portion supported by the non-critical portion. The press end of the micro-channel forming tool is driven into the plastic surface at a predetermined force using a pressing device. Ultrasonic vibrations are applied to the micro-channel forming tool for a predetermined amount of time to melt portions of the plastic surface in contact with the pressing surface. The ultrasonic vibrations are removed after the predetermined amount of time has elapsed and the press end is retracted from the plastic surface.

Additive manufacturing processes and manufactured article

An additive manufacturing process includes forming an object material stack using sheet materials without use of binder material between the sheet materials and forming features of the cross-sectional layers of a 3D object in the corresponding sheet materials. Another process involves forming features of the cross-sectional layers of a 3D object in soot layers of a laminated soot sheet. A manufactured article includes three or more glass layers laminated together without any binder material between the glass layers. At least one of the glass layers is composed of silica or doped silica, and at least one feature is formed in at least one of the glass layers.

BIOACTIVE SUBSTANCE-CONTAINING NANOFIBERS AND USES THEREOF

An ultrafine fiber comprises a ceramic-based fibrous body and a biologically active substance encapsulated in the body, substantially encapsulated in the body, or surface-attached to the body. In an example, an ultrafine fiber comprises a core comprising a biologically active substance and a ceramic-based shell surrounding or substantially surrounding the core. 1. An ultrafine fiber comprising:a ceramic-based fibrous body; anda biologically active substance encapsulated in the body, substantially encapsulated in the body, or surface-attached to the body.2. The ultrafine fiber of claim 1 , wherein the body comprises a polymer and a ceramic gel network.3. The ultrafine fiber of claim 2 , wherein the polymer comprises a water-soluble polymer.4. The ultrafine fiber of claim 2 , wherein the ceramic gel network comprises at least one of a silica gel network and a bioactive glass gel network.5. The ultrafine fiber of claim 1 , wherein the fibrous body is a nanofiber or a microfiber.6. The ultrafine fiber of claim 1 , wherein the ceramic-based fibrous body comprises a core comprising the biologically active substance claim 1 , and a ceramic-based shell surrounding or substantially surrounding the core.7. The ultrafine fiber of claim 6 , wherein the core comprises a core polymer encapsulating or substantially encapsulating the biologically active substance claim 6 , and wherein the shell comprises a shell polymer and a ceramic gel network.8. The ultrafine fiber of claim 7 , wherein one or both of the core polymer and the shell polymer comprises a water-soluble polymer.9. The ultrafine fiber of claim 7 , wherein the ceramic gel network of the shell comprises at least one of a silica gel network and a bioactive glass gel network.10. The ultrafine fiber of claim 1 , wherein the biologically active substance comprises at least one of DNA claim 1 , RNA claim 1 , one or more proteins claim 1 , one or more viruses claim 1 , bacteria claim 1 , and mammalian cells.11. A reactive mat ...

VERTICALLY STACKED NANOFLUIDIC CHANNEL ARRAY

Techniques regarding a vertical nanofluidic channel array are provided. For example, one or more embodiments described herein can regard an apparatus that can comprise a semiconductor substrate and a dielectric layer adjacent to the semiconductor substrate. The dielectric layer can comprise a first nanofluidic channel and a second nanofluidic channel. The second nanofluidic channel can be located between the first nanofluidic channel and the semiconductor substrate. 1. An apparatus , comprising:a semiconductor substrate; anda dielectric layer adjacent to the semiconductor substrate, the dielectric layer comprising a first nanofluidic channel and a second nanofluidic channel, wherein the second nanofluidic channel is located between the first nanofluidic channel and the semiconductor substrate.2. The apparatus of claim 1 , wherein the dielectric layer is a silicon dioxide layer.3. The apparatus of claim 1 , further comprising:a first reservoir having a first parameter defined by the dielectric layer; anda second reservoir having a second parameter defined by the dielectric layer, wherein the first nanofluidic channel extends from the first reservoir to the second reservoir, and wherein the second nanofluidic channel extends the first reservoir to the second reservoir.4. The apparatus of claim 1 , wherein the semiconductor substrate forms a first side of the second nanofluidic channel.5. The apparatus of claim 1 , wherein the dielectric layer forms a first side of the first nanofluidic channel and a second side of the first nanofluidic channel claim 1 , and wherein the dielectric layer further forms a first side of the second nanofluidic channel and a second side of the second nanofluidic channel.6. The apparatus of claim 5 , further comprising:a first silicon layer that forms a third side of the second nanofluidic channel, wherein the third side of the second nanofluidic channel is parallel with the semiconductor substrate, and wherein the dielectric layer is ...

LIQUID HANDLING DEVICE

A liquid handling device has an accommodation part for accommodating a liquid, two or more flow paths each opening to a lower part of a side wall surface of the accommodation part, and a liquid movement suppression part that is disposed in the lower part of the side wall between the openings of two of the flow paths that are adjacent to each other and slows or stops the movement of the liquid along the corner formed by the lower surface of the accommodation part and the side wall surface. 1. A liquid handling device comprising:a housing part for housing liquid;two or more channels opening at an edge of a side wall surface of the housing part; anda liquid movement suppressing part disposed between openings of two of the channels adjacent to each other at the edge of the side wall surface, the liquid movement suppressing part being configured to delay or stop movement of liquid along the edge of the side wall surface.2. The liquid handling device according to claim 1 , wherein the liquid movement suppressing part is a recess or a protrusion formed on the side wall surface.3. The liquid handling device according to further comprising:a substrate including a through hole and two or more grooves whose end portion is connected with an edge of one opening of the through hole; anda film disposed on one surface of the substrate such that the film closes the one opening of the through hole and openings of the two or more grooves, wherein:the housing part is formed when the one opening of the through hole is closed with the film,the channel is formed when the openings of the grooves are closed with the film, andthe liquid movement suppressing part is a recess or a protrusion formed at the edge of the opening of the through hole. The present invention relates to a liquid handling device.In recent years, microchannel chips have been used to accurately and speedily analyze a trace substance such as protein and nucleic acid. Microchannel chips advantageously allow the amount of ...

METHOD FOR PRODUCING FINE STRUCTURES IN THE VOLUME OF A SUBSTRATE COMPOSED OF HARD BRITTLE MATERIAL

A method for producing a cavity in a substrate composed of hard brittle material is provided. A laser beam of an ultrashort pulse laser is directed a side surface of the substrate and is concentrated by a focusing optical unit to form an elongated focus in the substrate. Incident energy of the laser beam produces a filament-shaped flaw in a volume of the substrate. The filament-shaped flaw extends into the volume to a predetermined depth and does not pass through the substrate. To produce the filament-shaped flaw, the ultrashort pulse laser radiates in a pulse or a pulse packet having at least two successive laser pulses. After at least two filament-shaped flaws are introduced, the substrate is exposed to an etching medium which removes material of the substrate and widens the at least two filament-shaped flaws to form filaments. At least two filaments are connected to form a cavity.

Plastic microfluidic chip and methods for isolation of nucleic acids from biological samples

The present invention is directed to methods of manufacture of microfluidic chip such as a plastic microfluidic chips, which has channels packed with polymer-embedded particles and uses thereof. The chip of the present invention is designed for application of an untreated biological sample on the chip thus allowing isolation, purification and detection of biomolecules, such as nucleic acids, proteins or peptides in one step. The invention also provides a microfluidic chip for combined isolation, purification and detection of biomolecules thus providing a complete Lab-on-a-Chip analysis system for biomolecules such as nucleic acids and proteins. The chips of the invention can be adapted to perform highly specific immunoassays and diagnostic test, for example, for diagnosis of infectious agents, such as bacteria, viruses or parasites.

マイクロリアクタおよびマイクロ分析システム

　本発明は、信頼性の高い分析を可能とするマイクロリアクタおよびマイクロ分析システムを提供する。 本発明のマイクロリアクタの構成によれば、微細流路内で流体を流し、反応を行うチップタイプのマイクロリアクタであって、微細流路を形成したチップ基板と、張り合せ面に粘着層を有する被覆薄板とを含み、チップ基板の流路側の面と被覆薄板の張り合せ面とを圧着すればよく、他の接着方法よりも簡便に作製できる。その被覆薄板は、チップ基板と同一の材質であってもよいが、チップ基板とは異なる特性、例えば強い撥水性を付与できる。本発明のシステムは、試薬類、送液系エレメントを搭載した、検体ごとのチップと、装置本体である制御・検出コンポーネントとを別個にする構成である。微量分析に対し、クロス・コンタミネーション、キャリーオーバー・コンタミネーションが生じにくい。

Fluid mixing system by microchannel and mixing method thereof

본 발명은 서로 다른 성질의 유체 재료가 마이크로 채널을 유동하면서 혼합되도록 하는마이크로 채널형 유체 혼합기 시스템 및 마이크로 채널을 이용한 유체 혼합방법을 제공한다. 이와 같은 본 발명에 따른 마이크로 채널형 유체 혼합기 시스템 및 마이크로 채널을 이용한 유체 혼합방법은 마이크로 채널 내부에 유입되어 유체 재료와 물리적으로 상호작용하게 되는 자성 입자의 집합체와 자성 입자에 자기력을 부여하게 되는 자석이 구비되는 단순한 구성으로 이루어지고, 자석에 의해 부여되는 자기력의 벡터량이 시간의 경과에 따라 변동되어 자성 입자의 운동이 변동되면서 마이크로 채널 내부로 유입되는 유체 재료의 와류유동을 유도되도록 함으로써 유체 재료의 혼합효율이 증대되도록 한 것이다. The present invention provides a microchannel type fluid mixer system and a method of fluid mixing using microchannels to allow fluid materials of different properties to be mixed while flowing microchannels. Such a microchannel fluid mixer system and a fluid mixing method using a microchannel in accordance with the present invention is a magnet that imparts a magnetic force to the aggregate and magnetic particles of the magnetic particles that are introduced into the microchannel to physically interact with the fluid material It consists of a simple configuration provided, and the amount of the magnetic force applied by the magnet is changed over time to induce the vortex flow of the fluid material flowing into the microchannel as the movement of the magnetic particles is changed to The mixing efficiency is to be increased. 본 발명에 따른 마이크로 채널형 유체 혼합기 시스템은 마이크로 채널, 자석체, 자성 입자 집합체(magnetic particles)로 이루어진다. 마이크로 채널은 서로 다른 성질의 유체 재료가 유입되는 유입구와 서로 다른 성질의 유체 재료가 혼합된 혼합 유체가 배출되는 유출구가 양단부에 형성되고, 유입구와 유출구 사이에 유입구를 통해 유입된 서로 다른 성질의 유체 재료가 유동하게 되는 내부유로가 형성된 것이다. 자석체는 마이크로 채널의 길이방향을 따라 유입구와 유출구 사이에 설치되고, 마이크로 채널의 둘레에 위치되어 마이크로 채널의 내부유로에 자기장이 작용하도록 하는 것이다. 자성 입자 집합체는 마이크로 채널의 내부유로에 유입되고, 자석체의 자기장을 통해 부여되는 자기력에 의해 마이크로 채널의 내부유로 상에서 운동하게 되는 것이다. 이와 같은 본 발명에 따른 마이크로 채널형 유체 혼합기 시스템에서 자석체는 자기장이 시간의 경과에 따라 변동되도록 하여 자성 입자 집합체의 운동 방향 및 운동 속도가 시간에 따라 달라지도록 하는데, 이에 따라 마이크로 채널의 내부유로로 유입된 서로 다른 성질의 유체 재료는 자성 입자 집합체와의 상호작용에 의해 와류 유동(vortex motion)하게 되면서 서로 혼합되게 된다. The microchannel fluid mixer system according to the present invention consists of a microchannel, a magnet body, and magnetic particles. The microchannel has an ...

Micro channel reactor

A microchannel reactor is provided to mix the different kinds of fluids within a short time by passing the fluids through a three-dimensional passage branching and joining the fluids by repeatedly moving the fluids in longitudinal and vertical directions. The microchannel reactor(50) comprises a fluid input unit having input pipes through which the fluids to be mixed are injected; a fluid mixing unit mixing the fluids; and a fluid discharging unit discharging the mixed fluid. The fluid mixing unit is composed of a lower plate(21) having plural doughnut-shaped channels arranged on the upside at predetermined depth in the longitudinal direction and a longitudinal passage for communicating the doughnut-shaped channels with each other by connecting the ends of the doughnut-shaped channels to each other; a middle plate(22) stacked on the lower plate and composed of plural doughnut-shaped channels(22a') arranged at the upper and rear sides at predetermined depth in the longitudinal direction, a communicating part(22b') for making the doughnut-shaped channels communicate with each other by connecting the ends of the doughnut-shaped channels to each other, and a three-dimensional passage channel repeatedly moving the fluids in longitudinal and vertical directions, wherein the doughnut-shaped channel formed in the rear side communicates with the passage channel of the lower plate by disposing the communicating part in the center of the doughnut-shaped channel of the lower plate and the doughnut-shaped channel formed on the upper side is positioned on the same axial line of the doughnut-shaped channel of the lower plate to communicate with the passage channel of the lower plate and the doughnut-shaped channel formed at the lower side; and an upper plate(23) stacked on the middle plate.

Method and device for thermal insulation of micro-reactors

Serpentine laminating chaotic micromixer

본 발명에 따른 마이크로 믹서는, 유입채널과 유출채널 사이에서 이들과 연결되면서 연이어 배치되어 상기 주입된 유체를 혼합시키는 제1 혼합유닛과 제2 혼합유닛을 구비하는 혼합부를 포함한다. 상기 제1 혼합유닛은, 유입채널로부터 분지(分枝)되어 유입채널 진행방향에 대한 제1 측편을 향해 연장되는 적어도 한 쌍의 1차 분할채널과, 상기 1차 분할채널과 서로 다른 층으로 배치되면서 상기 1차 분할채널의 각 끝단과 연통되는 1차 합류채널을 포함하며, 상기 제2 혼합유닛은, 1차 합류채널로부터 분지(分枝)되어 상기 제1 측편과 반대방향인 제2 측편을 향해 연장되는 적어도 한 쌍의 2차 분할채널과, 상기 2차 분할채널과 서로 다른 층으로 배치되면서 상기 2차 분할채널의 각 끝단과 연통되는 2차 합류채널을 포함하고, 상기 2차 합류채널은 상기 유출채널로 이어진다. 제1 혼합유닛과 제2 혼합유닛은 전체적으로 3차원 나선형 유로를 형성하게 되어, 상기 주입된 유체를 이를 통하여 이송하면서 분할 및 재배열의 카오스 혼합 메커니즘과 카오스 이류의 카오스 혼합 메커니즘을 결합하여 혼합시킨다. 마이크로 믹서, 혼합유닛, 분할채널, 합류채널, 카오스, 3차원 나선형 유로

Fluidic mixer in microfluidic system

Microfluidic devices capable of efficiently mixing one or more fluids are described. Two or more microfluidic channels within the device meet at an overlap region. The overlap region may be in fluid communication with an outlet channel. The inlet channels are disposed within different layers of a three dimension device. Microfluidic separators for separating multiphase fluids are also described. In this case, a multiphase fluid flows through an inlet channel into an overlap region from where the separated phases can be withdrawn through outlet channels. Also provided are methods for mixing and separating fluids in such devices.

Microfluidic separators

Microfluidic separators for separating multiphase fluids are described. Two or more microfluidic outlet channels within the device meet at an overlap region. The overlap region may be in fluid communication with an inlet channel. The inlet channel and each outlet channel are disposed within different layers of a three-dimensional device. Each channel is defined through the entire thickness of a stencil layer. A multiphase fluid flows through an inlet channel into an overlap region from where the separated phases can be withdrawn through the outlet channels.

High throughput screening of crystallization materials

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

High throughput screening of crystallization of materials

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

Methods and materials for fabricating microfluidic devices

Materials and methods are provided for fabricating microfluidic devices. The materials include low surface energy fluoropolymer compositions having multiple cure functional groups. The materials can include multiple photocurable and/or thermal-curable functional groups such that laminate devices can be fabricated. The materials also substantially do not swell in the presence of hydrocarbon solvents.

A microfluidic device and a method for preparing the microfluidic device from a photosensitive element

A microfluidic device is formed from a cover member and a microfluidic precursor that is prepared from a photosensitive element. The photosensitive element is a solid layer of a photopolymerizable composition that includes at least a binder, a monomer, and a photoinitiator. A method for forming the microfluidic device from the photosensitive element includes imagewise exposing the photopolymerizable layer to actinic radiation through a mask and treating to form a relief surface having microstructures or features, such as one or more channels and one or more chambers, that are suitable for use in the microfluidic device. The method provides microstructures that can be formed to have different dimensions that provide particular advantages for a microfluidic device that is operated by degas-driven flow to transport a fluid through the microstructures.

Methods and materials for fabricating microfluidic devices

High throughput screening of crystallization of materials

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

Micro mixer and method for fabricating thereof

본 발명은 마이크로 믹서 내를 유동하는 혼합 대상 유체가 반복하여 분리 및 적층되도록 구성됨으로써 혼합 효과가 우수한 마이크로 믹서 및 그 제조방법에 관한 것이다. 본 발명은, 서로 다른 유체가 각각 주입되는 제1주입구 및 제2주입구; 상기 제1주입구 및 제2주입구로 주입된 각각의 유체가 합류되어 지나는 유입구; 상기 주입된 유체가 혼합되어 유출되는 유출구; 및 상기 유입구와 상기 유출구 사이에 하나 이상이 일련으로 배치되는 혼합부;를 포함하고, 상기 혼합부는, 상기 유입구로부터 연장되는 메인유로; 상기 메인유로로부터 분기되어 중단되는 하나 이상의 분기유로; 및 상기 분기유로 및 상기 메인유로와 다른 층에 형성되고, 일단은 상기 분기유로와 연통되며, 타단은 상기 메인유로와 연통되는 보조유로;를 포함한다. The present invention relates to a micromixer having excellent mixing effect and a method of manufacturing the same by being configured to repeatedly separate and stack the fluid to be mixed flowing in the micromixer. The present invention, the first inlet and the second inlet through which different fluids are respectively injected; An inlet through which the respective fluids injected into the first inlet and the second inlet are joined; An outlet through which the injected fluid is mixed and discharged; And at least one mixing unit disposed in series between the inlet and the outlet, wherein the mixing unit comprises: a main flow passage extending from the inlet; At least one branch passage branching off from the main passage; And an auxiliary flow path formed on a different layer from the branch flow path and the main flow path, one end of which is in communication with the branch flow path, and the other end of which is in communication with the main flow path.

Fracture-resistant micromachined devices

A method for forming micromachined devices out of a polycrystalline silicon substrate using deep reactive ion etching to form the micromachined device. The method comprises the steps of providing a bulk material substrate of polycrystalline silicon, and etching the bulk material using deep reactive ion etching to form the micromachined device. The present invention also includes a method for forming a micromachined device comprising the steps of providing a first layer of single crystal silicon and etching a first set of elements on the first layer. The method further includes the steps of providing a second layer of single crystal silicon, etching a second set of elements on the second layer, and joining the first and second layers together such that the crystal planes of the first layer and the second layer are misaligned and such that the first set and the second set of elements are properly aligned.

Channel device

流路デバイスは、流体が流れる窪みが形成された基板と、窪みの底面から延びる複数の柱とを備える。複数の柱のそれぞれは、環形状または弧形状を有する複数の溝が形成された側面を有する。この流路デバイスは柱の損傷を抑制し、高い信頼性を有する。 The flow path device includes a substrate on which a recess through which a fluid flows is formed, and a plurality of columns extending from the bottom surface of the recess. Each of the plurality of pillars has a side surface in which a plurality of grooves having an annular shape or an arc shape is formed. This flow path device suppresses column damage and has high reliability.

A microfluidic device and a method for preparing the microfluidic device from a photosensitive element

Manufacturing method of a microchemical chip made of a resin and a microchemical chip made of a resin by the method

A manufacturing method of a microchemical chip made of a resin and having a micro channel, which comprises forming a photoresist film over the surface of one side of a metal support substratum, stacking a photomask for the formation of a channel pattern over the photoresist film, forming a minute-structure photoresist pattern over the metal support substratum by a photofabrication technology as a flat-sheet mold, disposing the flat-sheet mold or unit mold obtained by separating the flat-sheet mold on the bottom of a contour forming frame for resin molding, pouring a resin into the contour forming frame for resin molding and curing the resin to form a resin structure having a micro channel formed by the mold, and attaching the resin structure having a micro channel to a flat sheet to be a lid of the micro channel; and microchemical chips manufactured by this method.

Microchip manufacturing method

Microbead-filled microsystem and production method thereof

The invention relates to a micro-system intended to receive beads and to obtain a precise positioning of the beads at preset locations in the micro-system. This micro-system comprises a tank that has a cavity, the cavity being fitted with blocking elements allowing the beads to be ordered and stacked in the interstices between the blocking elements, the interstices constituting the preset locations. It also comprises a cap anchored hermetically to the tank and input means and output means allowing a fluid to flow in the cavity. The invention also relates to the implementation and use of the bead-filled micro-system.

Microfluidic device

A microfluidic device (100) comprising: a substrate (110) having a liquid channel (120), an ordered set of pillars (130) positioned in the channel (120), the individual pillars (130) comprising at least one pair of fins that form a chevron-shaped cross- section with the substrate, and being arranged in pairs of rows, adjacent rows being laterally displaced with respect to one another by half a pillar in length, the pillar length being measured perpendicular to the average liquid direction, thereby forming microchannels between the pillars, and the rows being staggered so that the microchannels formed between pillars of successive rows at each position along the longest pillar side have substantially the same width.

Reactor

A reactor comprising a platform, the platform at least defining: at least one fluid reservoir arranged to receive fluid; a plurality of reaction chambers, wherein the reaction chambers are discrete from each other; a plurality of supply channels for transporting fluid from the at least one fluid reservoir to one or more of the plurality of reaction chambers; pumping means arranged to pump fluid through one or more of a plurality of supply channels.A method of manufacturing the reactor, and the use of the reactor and a kit comprising the reactor.

Microfluid-System-Supporting Unit And Production Method Thereof

The present invention relates to a microfluid-system-supporting unit, comprising a fixing layer formed on a substrate, a protective layer or a fixing layer, wherein part of at least one hollow filament in any shape is placed and fixed in the fixing layer. Thus, it provides a microfluid-system-supporting unit lower in surface irregularity even when there are multiple hollow filaments different in external diameter or the hollow filaments crosses each other and resistant to positional deviation of the hollow filament in the crossing regions, and a production method thereof.

Inertial pumps

Fluid mixing method in micro channel and system thereof

A method for mixing fluid in a micro-channel and a system using the same are provided to allow generating various flows of fluid in a micro-channel effectively, and to contribute to commercialization of micro-chip through various flow formation and control of fluid in a micro-channel. The method for mixing fluid in a micro-channel includes: generating an uneven zeta potential cylinder by combining (+) charged hemi-cylinder and (-) charged hemi-cylinder; forming electro-osmotic flow depending on the zeta potential of the generated cylinder by providing electric field to the two electrodes established on the both ends of channel; and inducing rotative flow of fluid in the micro-channel by different slip velocity induced into different direction. The system includes a micro- channel, a member including zeta potential, and an electrode installed outside the micro-channel to apply electric field.

Micro-fluidic chip and preparation method thereof and utilize its analytical equipment

根据本发明的实施例，提供微流控芯片及其制备方法以及利用其的分析装置。上述微流控芯片包括：基板，包括使流体流入的流入部、使上述流体移动的流体通道及排出上述流体的流出部；以及膜，附着于上述基板，从外部保护上述流入部、上述流出部及上述流体通道中的至少一个，上述流入部及上述流出部通过贯通基板的表面而体现，上述流体通道可从上述基板的表面凹陷而体现。

Nanowire and method for producing nanowire

Three-dimensional structure, method for making three-dimensional structure, and fluid ejection device

A three-dimensional ("3D") structure (100) for handling fluids, a fluid handling device containing the 3D structure (100), and a method of making the 3D structure (100) are provided. The three-dimensional structure (100) includes a composite film layer (124, 200, 240). The composite film layer (124, 200, 240) includes a first photoresist layer (210) derived from a photoresist resin having a first chemical property selected from a group consisting of epoxide equivalent weight, aromatic content, and crosslink density; and at least a second photoresist layer (214, 242) derived from a photoresist resin having a second chemical property selected from a group consisting of epoxide equivalent weight, aromatic content, and crosslink density, wherein the second chemical property is different from the first chemical property, and wherein the composite film layer (124, 200, 240) is configured to have varying mechanical and/or physical properties through a thickness (T) of the three-dimensional structure (100).

Microfluidic chip, method for manufacturing the same, and analyzer using the same

Micro-nano fluidic biochip for assaying biological sample

Disclosed is a micro-nano fluidic biochip for assaying a biological sample comprising a first substrate, a second substrate and a third substrate which are sequentially stacked from bottom to top, wherein an upper channel assembly disposed on the second substrate is coupled with the lower channel assembly provided on the first substrate, to form a microfluidic channel, and the microfluidic channel has nano interstices formed at both sides thereof, the nano interstices having a height less than that of the center of the channel.

Microreactor glass diaphragm sensors

Microfluidic devices having wall structures comprised of sintered glass frit and further including a glass, glass-ceramic or ceramic membrane structure sealed by a sintered seal to said wall structures, such that a a fluid passage or chamber is defined at least in part by the wall structures and said membrane structure. This allows for changes in pressure within the fluid passage or chamber to cause deflections of the membrane structure, providing for direct measurement of pressure within the device. The microfluidic device may have both floors and walls of sintered frit, or may have only walls of sintered frit, with planar floor-like substrate structures, thicker than the membrane structure defining the vertical boundaries of the internal passages. The device may include multiple fluid passages or chambers each defined at least in part by a membrane structure. Multiple membrane structures may be used in a single device, and one single membrane structure may be used for multiple passages or chamber.

Adiabatic method and apparatus for microreactor

本发明涉及用于微反应器绝热的方法及设备。本发明提供了一种微流控设备（104），包括：‑半导体衬底；‑在所述半导体衬底中的至少一个微反应器(105)；‑在所述半导体衬底中连接至所述至少一个微反应器(105)的一个或多个微流控通道(101)；‑结合至所述半导体衬底(900)以便密封所述一个或多个微流控通道(101)的覆盖层(106)；以及‑围绕所述至少一个微反应器(105)和所述一个或多个微流控通道(101)的至少一个贯通衬底的沟(100)。

Additive manufacturing processes and manufactured article

一種積層製造製程包括在片材之間沒有使用黏結材料的條件下，利用片材形成物件材料堆層及在對應片材內形成3D物件的橫截面層的特徵。另一製程涉及在分層的煙灰板的煙灰層內形成3D物件的橫截面層的特徵。一種製成品包含三個或三個以上玻璃層，該等玻璃層層壓至一起而之間不存在任意黏結材料。至少一個該等玻璃層由二氧化矽或摻雜二氧化矽製成，且至少一個特徵形成於至少一個該等玻璃層內。

Microchip and process for producing microchip

A microchip (1) in which a resinous film can be inhibited from sagging into a channel. The microchip (1) comprises: a resinous base (2) having a channel groove forme therein; and a resinous film bonded to that side of the base on which the channel groove has been formed. A fine channel (3) including channels (3A) and channels (3B) is formed by the channel groove and the resinous film (10). The total length of the channels (3B), which extend parallel to the X direction for the resinous base (2), is large than the total length of the channels (3A), which extend parallel to the Y direction for the resinous base (2). The resinous base (2) has been bonded to the resinous film so that the sides parallel to the channels (3B) are parallel to the TD for the resinous film and that the sides parallel to the channels (3A) are parallel to the MD for the resinous film.

Functional materials and novel methods for the fabrication of microfluidic devices

Self-limited, anisotropic wet etching of transverse vias in microfluidic chips

The present invention is notably directed to a method of fabrication of a microfluidic chip ( 1 ), comprising: providing (S 10 -S 20 ) a wafer ( 10, 12 ) of semiconductor material having a diamond cubic crystal structure, exhibiting two opposite main surfaces (S 1 , S 2 ), one on each side of the wafer, and having, each, a normal in the <100> or <110> direction; and performing (S 30 ) self-limited, anisotropic wet etching steps on each of the two main surfaces on each side of the wafer, to create a via ( 20, 20 a ) extending transversely through the thickness of the wafer, at a location such that the resulting via connects an in-plane microchannel ( 31 ) on a first one (S 1 ) of the two main surfaces to a second one (S 2 ) of the two main surfaces, the via exhibiting slanted sidewalls ( 20 s ) as a result of the self-limited wet etching. The invention further concerns microfluidic chips accordingly obtained.

The micro-system, for biological or chemical reactions, has a cavity containing vertical barriers for the structured particles to be distributed evenly and accurately in the spaces between them

The technique to charge a micro-system (1) with particles uses a reservoir (3) with a cavity (4) containing a number of barriers (5), as vertical columns in a regular bi-dimensional layout. The particles can be arranged and stacked in the gaps between the barriers. A cover (7) gives a hermetic seal to the reservoir. The assembly is fitted with an inflow (8) and an outflow (9) to give a fluid circulation through the cavity.

3D micro-structuring for the production of mixing and channel structures in multilayer technology for use in or for the construction of reactors

Die vorliegende Erfindung bezieht sich auf eine Kanalstruktur für einen Bioreaktor, biochemischen Reaktor, chemischen Reaktor oder einen Reformer umfassend mehrere aufeinander gestapelte Einzelschichten mit jeweils mehreren die jeweilige Einzelschicht vollständig durchbrechenden Auslassungen, die dadurch gekennzeichnet ist, dass mindestens zwei unmittelbar benachbarte Einzelschichten jeweils mindestens einen Schichtabschnitt aufweisen, dessen Auslassungen in Form eines in zwei Dimensionen jeweils regelmäßigen Musters angeordnet sind und dass mindestens zwei der dergestalt mit einem solchen Muster versehenen Schichtabschnitte unmittelbar benachbarter Einzelschichten sich zumindest teilweise überlappen, wobei die Auslassungen der beiden sich zumindest teilweise überlappenden Schichtabschnitte im Überlappungsbereich relativ zueinander verdreht und/oder versetzt sind. The present invention relates to a channel structure for a bioreactor, biochemical reactor, chemical reactor or a reformer comprising several individual layers stacked one on top of the other, each with several openings which completely break through the respective individual layer, which is characterized in that at least two immediately adjacent individual layers each have at least one layer section whose openings are arranged in the form of a pattern that is regular in two dimensions and that at least two of the layer sections of directly adjacent individual layers provided with such a pattern at least partially overlap, the openings of the two at least partially overlapping layer sections being rotated relative to one another in the overlapping area and / or are offset.

Microfluidic devices

A microfluidic device may include a die package. The die package may include at least one fluidic die and an overmold material overmolding the fluidic die. The microfluidic device may also include a mesofluidic plate coupled to the die package. The mesofluidic plate includes at least one mesofluidic channel formed therein to fluidically couple the fluidic die.

Serpentine laminating chaotic micromixer

본 발명에 따른 마이크로 믹서는, 유입채널과 유출채널 사이에서 이들과 연결되면서 연이어 배치되어 상기 주입된 유체를 혼합시키는 제1 혼합유닛과 제2 혼합유닛을 구비하는 혼합부를 포함한다. 상기 제1 혼합유닛은, 유입채널로부터 분지(分枝)되어 유입채널 진행방향에 대한 제1 측편을 향해 연장되는 적어도 한 쌍의 1차 분할채널과, 상기 1차 분할채널과 서로 다른 층으로 배치되면서 상기 1차 분할채널의 각 끝단과 연통되는 1차 합류채널을 포함하며, 상기 제2 혼합유닛은, 1차 합류채널로부터 분지(分枝)되어 상기 제1 측편과 반대방향인 제2 측편을 향해 연장되는 적어도 한 쌍의 2차 분할채널과, 상기 2차 분할채널과 서로 다른 층으로 배치되면서 상기 2차 분할채널의 각 끝단과 연통되는 2차 합류채널을 포함하고, 상기 2차 합류채널은 상기 유출채널로 이어진다. 제1 혼합유닛과 제2 혼합유닛은 전체적으로 3차원 나선형 유로를 형성하게 되어, 상기 주입된 유체를 이를 통하여 이송하면서 분할 및 재배열의 카오스 혼합 메커니즘과 카오스 이류의 카오스 혼합 메커니즘을 결합하여 혼합시킨다. 마이크로 믹서, 혼합유닛, 분할채널, 합류채널, 카오스, 3차원 나선형 유로

A microfluidic device and a method for preparing the microfluidic device from a photosensitive element

A microfluidic device is formed from a cover member and a microfluidic precursor that is prepared from a photosensitive element. The photosensitive element is a solid layer of a photopolymerizable composition that includes at least a binder, a monomer, and a photoinitiator. A method for forming the microfluidic device from the photosensitive element includes imagewise exposing the photopolymerizable layer to actinic radiation through a mask and treating to form a relief surface having microstructures or features, such as one or more channels and one or more chambers, that are suitable for use in the microfluidic device. The method provides microstructures that can be formed to have different dimensions that provide particular advantages for a microfluidic device that is operated by degas-driven flow to transport a fluid through the microstructures.

Reactor

A reactor comprising a platform, the platform at least defining: at least one fluid reservoir arranged to receive fluid; a plurality of reaction chambers, wherein the reaction chambers are discrete from each other; a plurality of supply channels for transporting fluid from the at least one fluid reservoir to one or more of the plurality of reaction chambers; pumping means arranged to pump fluid through one or more of a plurality of supply channels.A method of manufacturing the reactor, and the use of the reactor and a kit comprising the reactor.

Functional materials and novel methods for the fabrication of microfluidic devices

目前公开的主题提供用于制造和利用微量设备如微流体设备的一种官能化全氟聚醚(PFPE)材料。所述官能化PFPE材料可用于将PFPE材料层彼此粘合或粘合于其它基材上以形成微量设备。此外，目前公开的主题提供将微流体通道和/或微滴定管的内表面官能化的方法。目前公开的主题还提供通过使用可降解材料的牺牲层制备微量结构的方法。

Methods of making microfluidic devices

Microfluidics has advanced in terms of designs and structures, however, fabrication methods are either time consuming or expensive to produce, in terms of the facilities and equipment needed. A fast and economically viable method is provided to allow, for example, research groups to have access to microfluidic fabrication. Unlike most fabrication methods, a method is provided to fabricate a microfluidic device in one step. In an embodiment, a resolution of 50 micrometers was achieved by using maskless high-resolution digital light projection (MDLP). Bonding and channel fabrication of complex or simple structures can be rapidly incorporated to fabricate the microfluidic devices.

Methods for making microfluidic devices and devices produced thereof

Described herein are methods for making microfluidic devices comprising glass or glass-containing materials, wherein the methods have decreased cost and/or improved dimensional properties over similar formed glass articles produced using current techniques.

Process for manufacturing integrated chemical microreactors of semiconductor material

The microreactor is completely integrated and is formed by a semiconductor body having a surface and housing at least one buried channel accessible from the surface of the semiconductor body through two trenches. A heating element extends above the surface over the channel and a resist region extends above the heating element and defines an inlet reservoir and an outlet reservoir. The reservoirs are connected to the trenches and have, in cross-section, a larger area than the trenches. The outlet reservoir has a larger area than the inlet reservoir. A sensing electrode extends above the surface and inside the outlet reservoir.

Method and device for thermal insulation of micro-reactors

【課題】断熱構造を持つマイクロ流体デバイスを提供する。 【解決手段】半導体基板と、半導体基板内の少なくとも１つのマイクロリアクタ１０５と、半導体基板内でマイクロリアクタに接続された１つ以上のマイクロ流体チャネル１０１と、マイクロ流体チャネルを封止するための、半導体基板に接合されたカバー層と、マイクロリアクタ及びマイクロ流体チャネルを包囲する基板貫通トレンチ１００とを備えたマイクロ流体デバイス１０４であって、基板貫通トレンチは空隙であるか、または断熱材料で充填されている、マイクロ流体デバイス 【選択図】図５

Nanowires and method for the production thereof

The invention relates to the production of segmented nanowires and components having said segmented nanowires. A template-based method is preferably used for producing the nanowire structural element, wherein electrochemical deposition of the nanowires takes place in nanopores. A plurality of nanowires thus is generated in the template foil. For the electrochemical deposition of the nanowires, an alternating sequence of cathodic deposition pulses and anodic counterpulses is performed. Segmented nanowires can be produced thereby.

Method for producing reconfigurable microchannels

A microfluidic device, including a microfluidic network, including: a) two parallel plates each including one or more electrodes, b) at least one channel, arranged between the two plates, made from a material obtained by solidification or hardening of a material of a first fluid, and c) a mechanism varying a physical parameter of the material constituting walls of the channel so as to cause the material to pass at least from the liquid state to the solid state.

Micro fluid system support and manufacturing method thereof

A support unit for a microfluidic system includes a first support; a first adhesive layer provided on a surface of the first support; and a hollow filament laid on a surface of the first adhesive layer to have an arbitrary shape and functioning as a flow channel layer of the microfluidic system.

MICROBED FOR MICROBALLS AND METHOD FOR THE PRODUCTION THEREOF

Photostructured chemical devices and methods for making same

A photostructurable ceramic is processed using photostructuring process steps for embedding devices within a photostructurable ceramic volume, the devices may include one or more of chemical, mechanical, electronic, electromagnetic, optical, and acoustic devices, all made in part by creating device material within the ceramic or by disposing a device material through surface ports of the ceramic volume, with the devices being interconnected using internal connections and surface interfaces.

Device and method for manufacturing the same

It is an object of this invention to prevent a resistor material and an electrode material from diffusing and suppress variation in electric resistance. In a device including a plurality of metal layers of different compositions on a substrate and a second structure made of a material, such as glass paste, requiring a firing process at the time of formation, an intermediate layer is formed between a first metal layer and a second metal layer forming the first structure. The intermediate layer is of an intermetallic compound including one or more metallic elements in the first metal layer and one or more metallic elements in the second metal layer. The melting point of the intermetallic compound is higher than a firing temperature when the second structure is formed, and the intermetallic compound is produced at a temperature higher than the firing temperature for forming the second structure.

Micro fluid system support and manufacturing method thereof

A support unit for a microfluidic system includes a first support; a first adhesive layer provided on a surface of the first support; and a hollow filament laid on a surface of the first adhesive layer to have an arbitrary shape and functioning as a flow channel layer of the microfluidic system.

Nanowire structural element

The invention relates to a nanowire structural element suitable for installing, for example, in a microreactor system or microcatalyst system. A template-based method is used for producing the nanowire structural element, wherein electrochemical deposition of the nanowires takes place in nanopores. Irradiation takes place at various angles, so that a nanowire network is formed. The structured hollow space in the nanowire network is exposed by dissolving the template foil and removing the dissolved template material. The networking of the nanowires gives the nanowire structural element stability, and an electrical connection is established between the nanowires.

Liquid handling device

Method for producing fine structures in the volume of a substrate composed of hard brittle material

A method for producing a cavity in a substrate composed of hard brittle material is provided. A laser beam of an ultrashort pulse laser is directed a side surface of the substrate and is concentrated by a focusing optical unit to form an elongated focus in the substrate. Incident energy of the laser beam produces a filament-shaped flaw in a volume of the substrate. The filament-shaped flaw extends into the volume to a predetermined depth and does not pass through the substrate. To produce the filament-shaped flaw, the ultrashort pulse laser radiates in a pulse or a pulse packet having at least two successive laser pulses. After at least two filament-shaped flaws are introduced, the substrate is exposed to an etching medium which removes material of the substrate and widens the at least two filament-shaped flaws to form filaments. At least two filaments are connected to form a cavity.

Conformal film micro-channels for a fluidic micro analyzer

Embodiments of the invention relate to a fluid containment structure for a micro analyzer comprising one or more shelled thermal structures in contact with a thermally isolated component of the analyzer and wherein the shelled thermal structure comprises a conformal film and also comprises three walls of a channel and the thermally isolated component forms the fourth wall.

Microfluidic device and method for manufacturing microfluidic device

A microfluidic device in which a first substrate and a second substrate are joined via an adhesive layer, and in which a first fluidic channel and a second fluidic channel are formed between the first substrate and the second substrate, including a communication-reducing portion configured to reduce communication of air bubbles in the adhesive layer disposed in a region between the first fluidic channel and the second fluidic channel, wherein the communication-reducing portion includes a first region in which the adhesive layer is thinner than in peripheral regions due to existence of a projecting portion included in the first substrate, and a second region disposed next to the first region, in which the adhesive layer has lower density than in peripheral regions due to existence of a recessed portion or a through hole included in at least one of the first substrate and the second substrate.

Systems and methods for reaction and transport engineering via cellular fluidics

The present disclosure relates to an engineered, additively manufactured, microfluidic cellular structure formed from a plurality of cells, wherein the cells are each formed from a plurality of interconnected elements. The cells have voids and each cell is open at upper ends thereof. The cells each communicate at a point below its upper end with a common channel. The cells are each configured to accept a fluid and operate to channel the fluid into the common channel and to hold the fluid received therein for later selective withdrawal from the structure.

Microfluidic chip

Microfluidic component, reactor comprising a plurality of such components, and method for producing same

이 발명은 미소 유체 컴포넌트에 관한 것으로서, 폐쇄된 유체 라인을 포함하고, 금속 시트의 제1 섹션의 구조화 표면 및 금속 시트의 제2 섹션의 인접한 구조화 표면 또는 비구조화 표면으로 형성되는, 구조물을 갖는 금속 시트로 만들어지고, 금속 시트는 접어져서, 서로 일체로 연결된 섹션들이 서로의 상부에 표면 평행 방식으로 배치되게 한다. 금속 시트는 윤곽 엣지를 갖는 적어도 하나의 제3 섹션을 더 포함하고, 또한, 접어져서, 제3 섹션이 표면 평행 방식으로 지지되기도 하고, 윤곽 엣지가 제1 벽 섹션을 형성하며, 제1 섹션 또는 제2 섹션의 인접한 구조화 표면 또는 비구조화 표면은 개방된 유체 라인의 제2 벽 섹션을 형성하게 한다. 이 발명은 또한, 복수의 그러한 미소 유체 컴포넌트를 포함하는 미소 유체 반응기, 및 그러한 컴포넌트들을 생산하는 방법에 관한 것이기도 하다. The present invention relates to a microfluidic component comprising a closed fluid line and comprising a structured surface of a first section of a metal sheet and an adjacent structured or unstructured surface of a second section of the metal sheet, And the metal sheet is folded so that the sections integrally connected to each other are arranged in a surface parallel manner on top of each other. The metal sheet further comprises at least one third section having a contoured edge and is also folded such that the third section is supported in a surface parallel manner and the contour edge forms a first wall section, The adjacent structured or unstructured surface of the second section forms a second wall section of the open fluid line. The invention also relates to a microfluidic reactor comprising a plurality of such microfluidic components, and to a method of producing such components.

Master and microreactors

マスターと成形用金型との離型性を向上させる。上記課題を解決するために、本発明に係るマスター４０は、成形用金型の母体となるもので、樹脂成型品の流路に相当する溝４３を有しており、溝４３の底面部４３ａの断面が曲面状を呈している。 Improve releasability between master and mold. In order to solve the above problems, the master 40 according to the present invention is a base of a molding die, and has a groove 43 corresponding to a flow path of a resin molded product, and a bottom surface portion 43a of the groove 43. The cross section is curved.

Method for making microfluid devices

本文描述了制造包含玻璃材料或含玻璃材料的微流体器件的方法，与使用现有技术生产的类似玻璃成形制品相比，本发明方法成本降低并且/或者维度性质提高。具体地说，提供具有图案化模塑表面的第一片刚性不粘材料片；提供第一用量的含玻璃组合物；使第一用量的含玻璃组合物接触图案化模塑表面，并且在图案化模塑表面和第二表面之间进行压制；将该片刚性不粘材料和第一用量的含玻璃组合物一起加热至足以软化该用量的含玻璃组合物的程度，从而在第一用量的含玻璃组合物中复制图案化模塑表面，形成含玻璃成形制品；密封含玻璃成形制品的至少一部分，形成其间具有至少一个流体通道的微流体器件。

The direct sealing of silica micro structure

用于密封玻璃微结构组件的方法的实施方式包括在基板上与玻璃微结构组件相邻提供一个或多个侧保持器构件，该侧保持器构件的高度小于玻璃微结构组件限定的未压缩的高度。该方法还包括在加热玻璃微结构组件和顶板至玻璃密封温度的同时，通过与玻璃顶层紧密接触的负载顶板压缩玻璃微结构组件，玻璃密封温度是足以使玻璃变粘的温度，其中玻璃微结构组件被压缩，直到负载顶板接触侧保持器构件，并且在玻璃密封温度下，负载顶板由侧保持器构件支撑的同时，该顶板的下表面保持粘附在玻璃顶层的上表面上。