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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 11073. Отображено 100.
10-09-2012 дата публикации

СКВАЖИННЫЙ ДАТЧИК, СОДЕРЖАЩИЙ НАНОДАТЧИК ДАВЛЕНИЯ, НАНОДАТЧИК ТЕМПЕРАТУРЫ, ХИМИЧЕСКИЙ НАНОДАТЧИК

Номер: RU0000120139U1

1. Скважинный нанодатчик, содержащий подложку с нанесенной на нее электропроводящей основой и диэлектрический материал, покрывающий, по крайней мере, часть проводящей основы и наноструктуры, нанесенные на диэлектрический материал между электропроводящими слоями, отличающийся тем, что в качестве наноструктуры используется диэлектрический полимерный пленочный материал, содержащий в своей структуре, по крайней мере, одну квантово-размерную структуру и позволяющий контролировать физические параметры скважинного флюида (химический состав (вода/нефть/газ), давление, температуру. 2. Скважинный нанодатчик по п.1, отличающийся тем, что в качестве наноструктуры, чувствительной к химическому составу скважинного флюида (вода/нефть/газ), используется пленка диэлектрического полимера с боковыми функциональными группами, содержащая, по крайней мере, два слоя и металлические слои, встроенные между этими слоями, не контактирующие между собой. 3. Скважинный нанодатчик по п.1, отличающийся тем, что в качестве наноструктуры, чувствительной к давлению, используется одна пленка из диэлектрического полимера с боковыми функциональными группами с нанесенными на верхнюю и нижнюю поверхности пленки металлическими слоями, соединенную с измеряемой средой посредством упругой мембраны. 4. Скважинный нанодатчик по п.1, отличающийся тем, что в качестве наноструктуры, чувствительной к температуре, используется одна пленка из диэлектрического полимера с боковыми функциональными группами с нанесенными на верхнюю и нижнюю поверхности пленки металлическими слоями, соединенную с измеряемой средой посредством металлического теплопровода. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 120 139 U1 (51) МПК E21B 47/06 (2012.01) B82Y 15/00 (2011.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ 2012114461/03, 12.04.2012 (24) Дата начала отсчета срока действия патента: 12.04.2012 (45) Опубликовано: 10.09.2012 Бюл. № 25 (73) Патентообладатель(и): Открытое ...

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29-07-2019 дата публикации

Устройство для измерения теплофизических свойств модифицированных грунтов

Номер: RU0000191202U1

Заявляемое устройство для измерения теплофизических свойств модифицированных грунтов позволяет проводить исследования теплофизических свойств различных веществ в условиях с контролируемой атмосферой. Устройство позволяет размещать внутри корпуса несколько различных типов нанокалориметрических сенсоров (XEN-40014, XEN Т08, FlashDSC chip). Устройство может быть интегрировано в приборы для измерения теплофизических и оптических параметров образцов. Устройство расширяет возможности методов нанокалориметрии за счет реализации возможности нагрева образца до 400°С и охлаждения образца до 25°С в условиях со строго заданным значением относительной влажности внутри измерительной камеры. Кроме того, конструкция устройства позволяет использовать сенсоры, имеющие две активные зоны, одну из которых можно использовать в качестве эталонной ячейки. Устройство включает корпус, выполненный с возможностью подключения к коннектору и снабженный окнами из рентгенопрозрачного материала, в котором размещен нанокалориметрический сенсор. В крышке и основании корпуса имеются специальные вырезы для установки прозрачных окон, с обеспечением размещения активной части сенсора в проекции этих вырезов. В корпус встроена электрическая плата для возможности подключения различных сенсоров. Технический результат - расширение возможности методов нанокалориметрии за счет обеспечения возможности точного регулирования параметров атмосферы вокруг нанокалориметрического сенсора. 5 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 191 202 U1 (51) МПК G01K 17/00 (2006.01) G01N 25/20 (2006.01) B82Y 15/00 (2011.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК G01N 25/20 (2018.08); G01K 17/006 (2018.08); B82Y 15/00 (2018.08) (21)(22) Заявка: 2018146728, 26.12.2018 (24) Дата начала отсчета срока действия патента: Дата регистрации: 29.07.2019 (45) Опубликовано: 29.07.2019 Бюл. № 22 Адрес для переписки: 141700, Московская обл., г. Долгопрудный, Институтский пер., 9, ...

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19-01-2012 дата публикации

Electrostatically regulated atomic scale electroconductivity device

Номер: US20120013324A1

An atomic scale electroconductivity device with electrostatic regulation includes a perturbing species having a localized electronic charge. A sensing species having an electronic conductivity is placed in proximity to the perturbing species at a distance sufficient to induce a change in the electronic conductivity associated with the localized electronic charge. Electronics are provided to measure the conductivity via the sensing species. A temporally controlled atomic scale transistor is provided by biasing a substrate to a substrate voltage with respect to ground.

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23-02-2012 дата публикации

Automated detection and counting of biomolecules using nanoparticle probes

Номер: US20120046191A1
Принадлежит: Oregon Health Science University

An apparatus and method for counting nanoparticle probes is disclosed. In one embodiment, quantum dot-tagged proteins on optically transparent membranes or slides are counted. The transparent membranes or slides are loaded onto a stage (e.g., an X-Y stage or X-Y-Z stage), which can automatically reposition the transparent membrane or slides for image capture at varying locations. A microscope can be used for providing a light source to fluoresce the nanocrystals and for providing the magnification needed for image capture. Once one or more images are captured, the nanoparticles can be automatically counted using post-processing software that maintains a total count across multiple images, if desired.

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01-03-2012 дата публикации

Ion sensor for measuring ion concentration of a solution

Номер: US20120048733A1
Принадлежит: National Chiao Tung University NCTU

An ion sensor includes: a conductive base structure including a substrate and an electrode film formed on the substrate; a plurality of ion-sensitive nanorods protruding from the electrode film; and an encapsulant enclosing the conductive base structure, surrounding the ion-sensitive nanorods, and formed with a window for exposing the ion-sensitive nanorods. Each of the ion-sensitive nanorods has a conductive core and an ion-sensitive layer formed on and enclosing the conductive core. The ion-sensitive material exhibits an ion selectivity of absorbing an ion of interest thereon for inducing a surface potential corresponding to concentration of the ion of interest.

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15-03-2012 дата публикации

Quantum dot-encoded bead set for calibration and quantification of multiplexed assays, and methods for their use

Номер: US20120065090A1
Принадлежит: Life Technologies Corp

Control beads are disclosed that allow for improved quantitation of analytes in multiplexed bead assays. The control beads have a range of concentrations of calibration moieties that provide for the preparation of a titration curve. The titration curve can be used to quantify the concentration of the analytes. The titration curve can be used to correlate the signal obtained from a bead with the concentration (or absolute number of molecules) of the analyte bound to the bead.

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05-04-2012 дата публикации

Method for detecting ligand using fret biosensor

Номер: US20120083048A1

The present application relates to a method for detecting ligand using a biosensor applied the FRET(fluorescence resonance energy transfer) phenomenon. More particularly, the method may be used for simply detecting a ligand in a sample by measuring the FRET of a biosensor under the conditions in which a specific critical temperature is maintained. The method may use a phenomenon in which a ligand-binding protein in a biosensor shows reversible unfolding at a temperature higher than the specific critical temperature and the level of the unfolding changes depending on the concentration of a ligand. The method can be widely applied to a variety of kinds of FRET biosensors using the ligand-binding protein.

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05-04-2012 дата публикации

Imaging Method and Use Thereof

Номер: US20120084015A1
Автор: Christoph Riethmuller
Принадлежит: Individual

The present invention relates to a method based on atomic force microscopy and the use thereof on biological surfaces. A method is provided to detect the Local Deviational Volume (LDV) of defined subcellular structures irrespective of a biochemical characterisation

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12-04-2012 дата публикации

Metamaterial Particles for Near-Field Sensing Applications

Номер: US20120086463A1
Принадлежит: Individual

A method and structure for designing near-field probes with high sensitivity used in detecting a wide variety of materials and objects such as biological anomalies in tissues, cracks on metallic surfaces, location of buried objects, or composition of material such as permittivity and permeability . . . etc., is disclosed. The present invention includes using single or multiple metamaterial unit cells or metamaterial particles as near-field sensors. Metamaterial unit cells are defined as the building blocks used for fabricating metamaterials that provide electrical or magnetic properties not found in naturally occurring media. Metamaterial unit cells or particles include split-ring resonators, complementary split-ring resonators, or a variety of other electrically-small resonators made of conducting wires or conducting flat surfaces. Metamaterial unit cells are excited by appropriate excitations such as small loops, microstriplines, etc. depending on the electromagnetic properties of the metamaterial unit cell. Once the metamaterial unit cell is excited, the reflection and transmission coefficients from the excitation mechanism can be measured.

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03-05-2012 дата публикации

High sensitivity localized surface plasmon resonance sensor and sensor system using same

Номер: US20120105857A1

The present invention relates to a high sensitivity localized surface plasmon resonance sensor and to a sensor system using same, the sensor comprising: a first metal layer including a first metal; a second metal layer arranged parallel to the first metal layer and including a second metal; and a conductive cross-linking layer disposed between the first metal layer and the second metal layer, and made of a third metal with a corrosion response that is different than that of the first metal and of the second metal.

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03-05-2012 дата публикации

Luminescent chemical sensor integrated with at least one molecular trap

Номер: US20120107948A1
Принадлежит: Hewlett Packard Development Co LP

A luminescent chemical sensor integrated with at least one molecular trap. The luminescent chemical sensor includes at least one molecular trap and at least one metallic-nanofinger device integrated with at least one molecular trap. The molecular trap includes a plurality of electrodes that trap at least one analyte molecule. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofinger of the plurality includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with the analyte molecule. A method for using, and a chemical-analysis apparatus including the luminescent chemical sensor are also provided.

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03-05-2012 дата публикации

Methods and apparatus for nanoparticle-assisted nucleic acid hybridization and microarray analysis

Номер: US20120108451A1
Автор: Lin Wang, Paul Chi Hang Li
Принадлежит: SIMON FRASER UNIVERSITY

The invention provides nucleic acid hybridization methods for detecting target nucleic acid sequences wherein complexes comprising nanoparticles non-covalently associated with single-stranded tartlet nucleic acid molecules are incubated with immobilized probe nucleic acid molecules. Because the nanoparticles function as competitors in the hybridization reaction between the target nucleic acid molecules and the probe nucleic acid molecules. The methods provide a high degree of discrimination between a perfectly matched target sequence and a sequence having at least a single-base-pair mismatch, even when the hybridization reaction is performed at room temperature. The invention also provides microarray methods and apparatus which incorporate the nanoparticle-assisted hybridization methods.

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10-05-2012 дата публикации

Method for detecting an analyte gas using a gas sensor device comprising carbon nanotubes

Номер: US20120111093A1
Принадлежит: Individual

This invention relates generally to gas sensors comprising organized assemblies of carbon and non-carbon compounds. The invention also relates to devices containing such gas sensors and analysis units. In preferred embodiments, the organized assemblies of the instant invention take the form of nanorods or their aggregate forms. More preferably, a nanorod is made up of a carbon nanotube filled, coated, or both filled and coated by a non-carbon material. The invention further relates to a method for detecting or quantitating an analyte gas.

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17-05-2012 дата публикации

Method for electric measurement of peroxide using cnt sensor

Номер: US20120118761A1

Disclosed is a method for measuring the concentration of a peroxide using a CNT sensor. The CNT sensor comprises a working electrode that is arranged on an insulating substrate, a monolayered carbon nano-tube that is contacted with the working electrode, a counter electrode, and a reference electrode. A sample is provided on the monolayered carbon nano-tube, and a potential difference is made between the working electrode and the counter electrode. In this manner, the concentration of the peroxide in the sample can be measured. The measurement method can be applied to clinical tests or the like.

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17-05-2012 дата публикации

Sensing devices

Номер: US20120119315A1
Принадлежит: Individual

A sensing device ( 10, 10 ′) includes a substrate ( 14 ), and first and second electrodes (E IC , E ICS , E O ) established on the substrate ( 14 ). The first electrode (E IC , E ICS ) has a three-dimensional shape, and the second electrode (E O ) is electrically isolated from and surrounds a perimeter of the first electrode (E IC , E ICS ).

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17-05-2012 дата публикации

Biodegradable and thermosensitive poly(organophosphazene)-superparamagnetic nanoparticle complex, preparation method and use thereof

Номер: US20120121517A1

The present invention relates to a poly(organophosphazene)-superparamagnetic nanoparticle complex including a biodegradable and thermosensitive poly(organophosphazene) and a iron oxide (Fe 3 O 4 , Magnetite)-series ferrite superparamagnetic nanoparticle, a preparation method, and uses of carrying a physiologically-active material, a bio-material and a biomaterial for cancer hyperthermia. The iron oxide is used as a MRI contrast agent for T- 2 and T 2 * weighted image, and the poly(organophosphazene) shows a sol-to-gel behavior depending upon the temperature change. The complex is a bound-type where the superparamagnetic ferrite nanoparticle is bonded to phosphazene-based polymer via hydrophobic binding, and a mixed-type where the superparamagnetic ferrite nanoparticle is physically mixed with the phosphazene-based polymer.

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31-05-2012 дата публикации

Gum arabic coated 198gold radioactive nanoparticles for cancer therapy

Номер: US20120134918A1
Принадлежит: University of Missouri System

The invention provides a cancer therapeutic and imaging agent comprising a solution containing Gum Arabic coated 198 Au nanoparticles. The Gum Arabic coated 198 Au nanoparticles have been demonstrated experimentally shown to have a surprising efficacy for a single dose direct injection, reducing tumors in analog mice by 82% over a short period of time. The particles of the invention have a believed optimal size for therapy and imaging applications, and can be used as a theranostic agent in the treatment of needle accessible cancers. The invention also provides a method for forming Gum Arabic coated 198 Au nanoparticles. A gold foil is irradiated to produce 198 Au foil. The foil is dissolved to form radioactive gold salt. The salt is dried, and then reconstituted to form a 198 Au nanoparticle precursor. The precursor is reduced with a reducing agent in an aqueous solution including Gum Arabic to form Gum Arabic coated 198 Au nanoparticles.

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21-06-2012 дата публикации

Nanoparticle composition and associated methods thereof

Номер: US20120156141A1
Принадлежит: General Electric Co

A nanoparticle composition is provided, wherein the composition comprises a nanoparticulate metal oxide; and a phosphorylated polyol comprising at least two phosphate groups. The polyol comprises one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. A method of making the nanoparticle composition is also provided. The nanoparticle compositions provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.

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28-06-2012 дата публикации

Chemical sensing and/or measuring devices and methods

Номер: US20120161207A1

Methods for fabricating silicon nanowire chemical sensing devices, devices thus obtained, and methods for utilizing devices for sensing and measuring chemical concentration of selected species in a fluid are described. Devices may comprise a metal-oxide-semiconductor field-effect transistor (MOSFET) structure.

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02-08-2012 дата публикации

Tumor tissue-selective bio-imaging nanoparticles

Номер: US20120195835A1
Автор: Kyoungja Woo, Myung-Ik YOO

A bio-imaging nanoparticle is composed of a core nanoparticle, a bonding layer having organic ligands, surfactants and polyoxyalkylene derivatives of fatty acid ester, and veiling the core nanoparticle, and functional molecules, wherein the organic ligands are bound to a surface of the core nanoparticle, the surfactants are bound to a portion of the surface of the core nanoparticle to which the organic ligands are not bound, the polyoxyalkylene derivatives of the fatty acid ester are introduced in an empty space between the organic ligands and the surfactants of the bonding layer, and the functional molecule is bound to a second terminal end opposite to a first terminal end of both terminal ends of the organic ligand, the first terminal end of the organic ligand being bound to a shell of the core nanoparticle.

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09-08-2012 дата публикации

Systems and methods for neutron detection using scintillator nano-materials

Номер: US20120199747A1

In one embodiment, a neutron detector includes a three dimensional matrix, having nanocomposite materials and a substantially transparent film material for suspending the nanocomposite materials, a detector coupled to the three dimensional matrix adapted for detecting a change in the nanocomposite materials, and an analyzer coupled to the detector adapted for analyzing the change detected by the detector. In another embodiment, a method for detecting neutrons includes receiving radiation from a source, converting neutrons in the radiation into alpha particles using converter material, converting the alpha particles into photons using quantum dot emitters, detecting the photons, and analyzing the photons to determine neutrons in the radiation.

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16-08-2012 дата публикации

Method for enhancing mass of gold nanoparticle through light-irradiation, method and sensor for detecting molecular binding using the method for enhancing mass

Номер: US20120208290A1

Provided are a sensor for detecting molecular binding by increasing the mass of a gold nanoparticle through light-irradiation and a method thereof. In the method, light-irradiation increases the size of gold nanoparticles without using a reducing agent, to enhance the mass. Accordingly, selectivity may be improved, and the sensitivity of detection may be improved due to a change in various properties of a gold nanoparticle.

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30-08-2012 дата публикации

Application of quantum dots for nuclear staining

Номер: US20120219948A1
Принадлежит: Ventana Medical Systems Inc

Embodiments of a system, method, and kit for visualizing a nucleus are disclosed. A tissue sample is pretreated with a protease to permeabilize the nucleus, and then incubated with a nanoparticle/DNA-binding moiety conjugate. The DNA-binding moiety includes at least one DNA-binding molecule. The conjugate binds to DNA within the nucleus, and the nanoparticle is visualized, thereby visualizing the nucleus. Computer and image analysis techniques are used to evaluate nuclear features such as chromosomal distribution, ploidy, shape, size, texture features, and/or contextual features. The method may be used in combination with other multiplexed tests on the tissue sample, including fluorescence in situ hybridization. Kits for performing the method include a protease enzyme composition, a nanoparticle/DNA-binding moiety conjugate, and a reaction buffer.

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06-09-2012 дата публикации

Device for recovering nanopowders and ultrafine powders contained in a gas

Номер: US20120222558A1

A device for recovering nanometer or sub-micron particles carried by a gas by generating a stabilized suspension, including: a vessel including a mechanism injecting a liquid; a gas discharge mechanism in an upper portion thereof, located near a particle filter; a particle suspension outlet; and a liquid ring pump, transferring and dispersing particles carried by a gas into a liquid. The pump introduces a gas laden with nanometer or sub-micron particles into the pump; injects at least one liquid into the pump; and discharges the mixture obtained following the transfer. The vessel also includes a mechanism introducing the mixture into the vessel and at least one piezoelectric pellet, immersed in the vessel, configured to generate a fog of micron-sized droplets.

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13-09-2012 дата публикации

Systems and methods for high-throughput detection of an analyte in a sample

Номер: US20120231960A1
Принадлежит: MagArray Inc

Provided are high-throughput detection systems. The systems include a magnetic sensor device, a magnetic field source and a reservoir plate that includes a plurality of fluid reservoirs. The magnetic sensor device includes a support with two or more elongated regions each having a magnetic sensor array disposed at a distal end. Also provided are methods in which the subject high-throughput detection systems find use.

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20-09-2012 дата публикации

Nanodevices for generating power from molecules and batteryless sensing

Номер: US20120237853A1

A nanoconverter or nanosensor is disclosed capable of directly generating electricity through physisorption interactions with molecules that are dipole containing organic species in a molecule interaction zone. High surface-to-volume ratio semiconductor nanowires or nanotubes (such as ZnO, silicon, carbon, etc.) are grown either aligned or randomly-aligned on a substrate. Epoxy or other nonconductive polymers are used to seal portions of the nanowires or nanotubes to create molecule noninteraction zones. By correlating certain molecule species to voltages generated, a nanosensor may quickly identify which species is detected. Nanoconverters in a series parallel arrangement may be constructed in planar, stacked, or rolled arrays to supply power to nano- and micro-devices without use of external batteries. In some cases breath, from human or other life forms, contain sufficient molecules to power a nanoconverter. A membrane permeable to certain molecules around the molecule interaction zone increases specific molecule nanosensor selectivity response.

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20-09-2012 дата публикации

Ultrasensitive Biochemical Sensing Device and Method of Sensing Analytes

Номер: US20120238471A1
Автор: Anatoliy Pinchuk
Принадлежит: University of Colorado

Systems and methods biochemically sense a concentration of a ligand using a sensor having a substrate having a metallic nanoparticle array formed onto a surface of the substrate. A light source is incident on the surface. A matrix is deposited over the nanoparticle array and contains a protein adapted to binding the ligand. A detector detects s-polarized and p-polarized light from the reflective surface. Spacing of nanoparticles in the array and wavelength of light are selected such that plasmon resonance occurs with an isotropic point such that −s and −p polarizations of the incident light result in substantially identical surface Plasmon resonance, wherein binding of the ligand to the protein shifts the resonance such that differences between the −S and −P polarizations give in a signal indicative of presence of the ligand.

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27-09-2012 дата публикации

Method of diagnosing, prognosing and monitoring alzheimer's disease

Номер: US20120245854A1
Автор: Hossam Haick, Urike Tisch

The present invention provides a system and method for diagnosing, monitoring or prognosing Alzheimer's disease using at least one sensor comprising carbon nanotubes coated with cyclodextrin or derivatives thereof and/or at least one sensor comprising metal nanoparticles coated with various organic coatings in conjunction with a learning and pattern recognition algorithm.

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04-10-2012 дата публикации

Device for the selective detection of benzene gas, method of obtaining it and detection of the gas therewith

Номер: US20120247180A1

Device for the selective detection of benzene gas, which comprises, on a base substrate, a combination of at least one functionalised multi- or single-wall carbon nanotube sensor decorated with rhodium clusters, and at least one functionalised multi- or single-wall carbon nanotube sensor decorated with metal clusters selected from gold, palladium, nickel and titanium, and/or undecorated, where said substrate additionally comprises means for measuring the variation in the resistance of said sensors. The device is useful at ambient temperature in the presence or absence of oxygen and easy to handle. It also relates to a method for the manufacturing thereof and for detecting the gas in the chemical industry, the petrochemical industry, petrol stations, or household, aeronautical or research applications.

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18-10-2012 дата публикации

Dna sequencing employing nanomaterials

Номер: US20120264617A1
Автор: John W. Pettit
Принадлежит: Individual

Charge transfer doped nanomaterials such as hydrogen terminated diamond, nanotubes, nanowires or similar nanostructures are used to create a highly sensitive pH sensor, or ion sensitive sensor to directly detect the addition of a newly incorporated nucleotide when performing DNA sequencing by synthesis. A single highly integrated chip can be made to sequence many strands of DNA in a massively parallel fashion in a short amount of time with a direct electronic readout that will bring the cost, size, power consumption of sequencing DNA to very attractive and useful levels.

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08-11-2012 дата публикации

Method of enhanced detection for nanomaterial-based molecular sensors

Номер: US20120282594A1
Принадлежит: Honda Motor Co Ltd

Sensors based on single-walled carbon nanotubes and graphene which demonstrate extreme sensitivity as reflected in their electrical conductivity to gaseous molecules, such as NO, NO 2 and NH 3 , when exposed to in situ ultraviolet (UV) illumination during measurement of the analytes are disclosed. The sensors are capable of detection limits of NO down to almost 150 parts-per-quadrillion (“ppq”), detection limits of NO 2 to 2 parts-per-trillion (“ppt”), and detection limits of NH 3 of 33 ppt.

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13-12-2012 дата публикации

Metallic Nanoparticle Pressure Sensor

Номер: US20120313860A1
Принадлежит: Individual

An electrical pressure sensor is provided with a method for measuring pressure applied to a sensor surface. The method provides an electrical pressure sensor including a sealed chamber with a top surface, first electrode, second electrode, an elastic polymer medium, and metallic nanoparticles distributed in the elastic polymer medium. When the top surface of the sensor is deformed in response to an applied pressure, the elastic polymer medium is compressed. In response to decreasing the metallic nanoparticle-to-metallic nanoparticle mean distance between metallic nanoparticles, the electrical resistance is decreased between the first and second electrodes through the elastic polymer medium.

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03-01-2013 дата публикации

Arrays Of Biological Membranes And Methods And Use Thereof

Номер: US20130005611A1
Принадлежит: Individual

The present invention overcomes the problems and disadvantages associated with prior art arrays by providing an array comprising a plurality of biological membrane microspots associated with a surface of a substrate that can be produced, used and stored, not in an aqueous environment, but in an environment exposed to air under ambient or controlled humidities. Preferably, the biological membrane microspots comprise a membrane bound protein. Most preferably, the membrane bound protein is a G-protein coupled receptor, an ion channel, a receptor serine/threonine kinase or a receptor tyrosine kinase.

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10-01-2013 дата публикации

Biochip

Номер: US20130011914A1
Автор: Sanghyo Kim

A biochip including a metal nanoparticle layer on a multilayer substrate can perform qualitative and quantitative analyses simply without a separate tag. A biochip including a metal nanoparticle layer on a multilayer substrate and using a CMOS image sensor can be an economically beneficial biochip reusable and convenient in use by employing a relatively simple detection method without a need of using a separate tag.

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31-01-2013 дата публикации

Polymer coated sers nanotag

Номер: US20130028839A1
Принадлежит: Becton Dickinson and Co

An encapsulated surface enhanced Raman scattering (SERS) tag. The tag includes a metal core and an encapsulant, typically a glass encapsulant. The encapsulant is further derivatized with a polymer.

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07-02-2013 дата публикации

Diagnosing, prognosing and monitoring multiple sclerosis

Номер: US20130034910A1
Автор: Ariel Miller, Hossam Haick

The present invention provides a system and method for diagnosing, monitoring or prognosing Multiple Sclerosis at different stages as well as affording the prediction of disease activity and response to a treatment regimen, using at least one sensor comprising carbon nanotubes or metal nanoparticles, each coated with various organic coatings in conjunction with a pattern recognition algorithm.

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14-02-2013 дата публикации

Fluorescent silica-based nanoparticles

Номер: US20130039848A1

The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as polyethylene glycol) (PEG) The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo The nanoparticle may further be conjugated to a ligand capable of binding to a cellular component associated with the specific cell type, such as a tumor marker A therapeutic agent may be attached to the nanoparticle Radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle to permit the nanoparticle to be detectable by various imaging techniques.

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14-02-2013 дата публикации

Analytical applications of enzymatic growth of fluorescent quantum dots

Номер: US20130040329A1

Methods for the detection/quantification of the enzymatic activity of hydrolases in a sample, wherein the hydrolase catalyses a hydrolysis reaction of a substrate which yields either H 2 S or a thiol-containing organic compound that produces a decomposition reaction which generates H 2 S, and methods for the detection/quantification of their substrates in a sample, as well as a method for the preparation of fluorescent CdS quantum dots, the preparation method, comprising first carrying out a enzymatic reaction catalysed by the hydrolase wherein the hydrolase catalyses the hydrolysis reaction of a substrate which yields either H 2 S or a thiol-containing organic compound that produces a decomposition reaction which generates H 2 S, and then reacting the resulting H 2 S with a salt of Cd +2 , thereby fluorescent CdS quantum dots are obtained.

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21-02-2013 дата публикации

Biosensor detecting thiol group and method for preparing the biosensor

Номер: US20130043862A1

There is provided a biosensor for detecting a thiol group and a method of manufacturing the biosensor. In detail, in the method, Au nano particles are manufactured by irradiating radiation (Step 1), a PTh-EDOT/ITO film is manufactured by forming a poly(thiophene-co-3,4-ethylenedioxythiophene) (PTh-EDOT) layer on an indium tin oxide (ITO) coated substrate using cyclic voltammetry (CV) (Step 2) (Step 2); and a Au nano particle modified PTh-EDOT/ITO film is manufactured by dispersing the Au nano particles manufactured in Step 1 onto the PTh-EDOT/ITO film manufactured in Step 2 (Step 3).

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28-02-2013 дата публикации

Method for sensing a chemical

Номер: US20130052632A1
Принадлежит: Vivacta Ltd

This invention relates to a method for detecting an analyte in a sample. The method comprises the steps of exposing the sample to a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing a change in energy to an electrical signal, the transducer having at least one reagent proximal thereto, the reagent having a binding site which is capable of binding the analyte or a complex or derivative of the analyte, wherein at least one of the analyte or the complex or derivative of the analyte has a label attached thereto which is capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; irradiating the reagent with a series of pulses of electromagnetic radiation, transducing the energy generated into an electrical signal, detecting the electrical signal and the time delay between each pulse of electromagnetic radiation from the radiation source and the generation of the electric signal. The time delay between each of the pulses of electromagnetic radiation and the generation of the electric signal corresponds to the position of the analyte at any of one or more positions at different distances from the surface of the transducer. The label is a nanoparticle comprising polypyrrole or a derivative thereof. The invention also provides a kit suitable for performing this method.

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28-02-2013 дата публикации

Methods for detecting DNA-binding proteins

Номер: US20130052638A1
Автор: Xiaodi Su, Yen Nee Tan

There is provided a method for detecting binding of a DNA-binding protein to a target recognition sequence. The method comprises mixing in a reaction buffer a first set of metal nanoparticles, a second set of metal nanoparticles and a DNA-binding protein to form a mixture, and detecting the aggregation state of the mixture of metal nanoparticles. Each set of metal nanoparticles has a conjugated double-stranded DNA molecule having a single-stranded overhang at one end. The single-stranded overhangs of each set of DNA-conjugated metal nanoparticles are complementary to each other such that annealing of the complementary overhangs results in formation of the target recognition sequence that specifically binds the DNA-binding protein. The reaction buffer comprises an ionic species in a concentration sufficient to result in aggregation of the metal nanoparticles upon annealing of the first and second single-stranded overhang.

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07-03-2013 дата публикации

Ultrasensitive biosensors

Номер: US20130056839A1
Автор: James HOLM-KENNEDY
Принадлежит: UNIVERSITY OF HAWAII

The present invention is a biosensor apparatus that includes a substrate, a source on one side of the substrate, a drain spaced from the source, a conducting channel between the source and the drain, an insulator region, and receptors on a gate region for receiving target material. The receptors are contacted for changing current flow between the source and the drain. The source and the drain are relatively wide compared to length between the source and the drain through the conducting channel.

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14-03-2013 дата публикации

Method of rapidly detecting microorganisms using nanoparticles

Номер: US20130065220A1

The present invention relates to a method of rapidly detecting microorganisms using nanoparticles, and more particularly to a method and device of rapidly detecting microorganisms by adding, to the microorganisms to be detected, nanoparticles having immobilized thereon an antibody that binds specifically to the microorganisms to be detected, subjecting the mixture to an immune reaction to form a reaction solution, passing the reaction solution through a microorganism-concentrating film to concentrate the microorganisms, capturing microorganisms, which was immune-reacted with the antibody-immobilized nanoparticles, by a microorganism-capturing filtration membrane, and determining the presence and concentration of the microorganisms. The present invention detects microorganisms using nanoparticles having immobilized thereon an antibody that binds specifically to the microorganisms to be detected, so that the presence and concentration of the microorganisms can be determined in a more effective and simpler manner than a conventional detection method, and the inventive method is effective in detecting a small amount of microorganisms owing to high sensitivity.

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21-03-2013 дата публикации

Method and System for Characterizing or Identifying Molecules and Molecular Mixtures

Номер: US20130071837A1
Принадлежит:

A system and method for identifying a material passing through a nanopore filter wherein an electrical signal is detected as a result of the passage and that signal is processed in real-time using mathematical and statistical tools to identify the molecule. A carrier molecule is preferably attached to one or more molecule(s) under consideration using a non-covalent bond and the pore in the nanopore filter is sized so that the molecule rattles around in the pore before being discharged without passing through the filter pore. The present invention includes not only a method and system for identifying the molecule(s) under consideration but also a kit for setting up the filter as well as mathematical tools for analyzing the signals from the sensing circuitry for the molecule(s) under consideration. 1. A device for identifying at least one molecule , the device comprising two chambers of buffer separated by a membrane over an aperture having at least one nanometer-scale nanopore channel in the membrane , with an applied potential applied between the two chambers , a single blockade molecule that enters the nanopore channel but does not pass immediately therethrough , remaining in the nanopore channel for a period of time and modulating the nanopore channel , a sensor generating electrical signals associated with the blockading molecule and at least one processor using an algorithm for analyzing the electrical signal to characterize the blockade molecule.2. The device according to claim 1 , wherein the membrane includes a plurality of nanopore-scale nanopore channels.3. The device according to further including a system to externally excite the nanopore-scale nanopore channel.4. The device according to further including a sensor for identifying a binding event in the blockade molecule.5. The device according to further including a selector to read one nanopore channel at a selected time.6. The device claim 1 , according to further including signal processing calibration ...

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28-03-2013 дата публикации

Ammonia Nanosensors, and Environmental Control System

Номер: US20130075690A1
Принадлежит: Nanomix, Inc.

Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes such ammonia. An environmental control system employing nanoelectronic sensors is described. A personnel safety system configured as a disposable badge employing nanoelectronic sensors is described. A method of dynamic sampling and exposure of a sensor providing a number of operational advantages is described. 1. A nanostructure sensor for sensing an analyte of interest in a sample , comprising:a substrate;a nanostructured element disposed adjacent the substrate;one or more conducting elements in electrical communication with the first nanostructure; andat least one functionalization operatively associated with the nanostructured element, the at least one functionalization configured to provide sensitivity for the analyte of interest.2. A sensor as in claim 1 , wherein the nanostructured element includes a network of carbon nanotubes disposed adjacent the substrate.3. A sensor as in claim 2 , wherein the analyte of interest includes ammonia.4. A sensor as in claim 2 , wherein the at least one functionalization includes an organic recognition material.5. A sensor as in claim 4 , wherein the organic recognition material includes a polymer.6. A sensor as in claim 5 , wherein the polymer includes at least one of a conductive polymer and a semi-conductive polymer.7. A sensor as in claim 4 , wherein the organic recognition material includes PABS.8. A sensor as in claim 4 , wherein the organic recognition material includes a nonionic surfactant.9. A sensor as in claim 4 , wherein the organic recognition material includes glycerol.10. A sensor as in claim 4 , wherein the network includes at least one SWNTs which is stably associated with the organic recognition material prior to formation of the network.11. A sensor as in claim 2 , wherein the at least one functionalization includes an inorganic recognition material.12. A sensor as in claim 2 , wherein the one or more conducting ...

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28-03-2013 дата публикации

NANO-ELECTRONIC SENSORS FOR CHEMICAL AND BIOLOGICAL ANALYTES, INCLUDING CAPACITANCE AND BIO-MEMBRANE DEVICES

Номер: US20130075794A1
Принадлежит:

Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes inorganic gases, organic vapors, biomolecules, viruses and the like. A number of embodiments of capacitive sensors having alternative architectures are described. Particular examples include integrated cell membranes and membrane-like structures in nanoelectronic sensors. 1. A sensor , comprising:a substrate;a conductive base disposed adjacent the substrate;a dielectric material covering at least a region of the conductive base;one or more nanostructures disposed adjacent the dielectric material and capacitively coupled to the conductive base; anda top lead electrically communicating to the one or more nanostructures.2. The sensor of claim 1 , wherein the one or more nanostructures comprises a network of carbon nanotubes.3. The sensor of further comprising a functionalization material disposed adjacent the carbon nanotubes.4. A sensor claim 2 , comprising:a substrate;a spaced-apart pair including a first and second conductive lead disposed adjacent the substrate;a dielectric material covering at least a region of at least one conductive lead; andone or more nanostructures disposed adjacent the dielectric material and capacitively coupled to at least one conductive lead.5. The sensor of claim 4 , wherein the one or more nanostructures comprises an electrically-continuous network including a plurality of carbon nanotubes spanning to cover at least a region of each conductive lead which separated from each lead by the dielectric material claim 4 , and wherein neither conductive lead is in contact with the network of carbon nanotubes.6. The sensor of claim 5 , wherein the spaced-apart pair of conductive leads have a characteristic separation gap “g” claim 5 , and wherein the carbon nanotubes have a characteristic length “L” claim 5 , and wherein “L” is significantly greater that “g”.7. The sensor of claim 5 , wherein substantial numbers of nanotubes span the gap so as to have ...

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28-03-2013 дата публикации

ELECTRONIC DEVICE FOR MONITORING SINGLE MOLECULE DYNAMICS

Номер: US20130078622A1

A single molecule sensing device includes a first electrode, a second electrode and a single-walled carbon nanotube (SWNT) connected to the first and second electrodes. At least one linker molecule having first and second functional groups is functionalized with a sidewall of the SWNT, the at least one linker molecule having the first functional group non-covalently functionalized with a sidewall of the single-walled carbon nanotube. A single sensitizing molecule having at least one functional group is functionalized with the second functional group of the at least one linker molecule. 1. A single molecule sensing device comprising:a first electrode;a second electrode;a conductive channel connected to the first electrode and the second electrode;at least one linker molecule having first and second functional groups, the at least one linker molecule having the first functional group non-covalently functionalized with the conductive channel; anda single sensitizing molecule having at least one functional group, said at least one functional group of the single sensitizing molecule being functionalized with the second functional group of the at least one linker molecule.2. The single molecule sensing device of claim 1 , wherein the conductive channel comprises a single-walled carbon nanotube.3. The single molecule sensing device of claim 1 , wherein the first functional group is a functional group which interacts with the conductive channel through pi-pi stacking.4. The single molecule sensing device of claim 2 , wherein the first functional group is a functional group which interacts with the sidewall of the single-walled carbon nanotube through pi-pi stacking.5. The single molecule sensing device of claim 1 , wherein the single sensitizing molecule having at least one functional group is selected from a group consisting of an enzyme claim 1 , a protein claim 1 , a nucleic acid claim 1 , a ribozyme claim 1 , an aptamer claim 1 , and a polysaccharide.6. The single ...

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28-03-2013 дата публикации

Preparation of microfluidic device on metal nanoparticle coated surface, and use thereof for nucleic acid detection

Номер: US20130078740A1
Принадлежит: UNIVERSITY OF ROCHESTER

The invention relates to a microfluidic device that utilizes nucleic acid-based detection and a detection system containing the same, as well as a process for preparing the micro fluidic device and for using the same to detect the presence of a target nucleic acid molecule in a sample.

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04-04-2013 дата публикации

NANOELECTROMECHANICAL TUNNELING CURRENT SWITCH SYSTEMS

Номер: US20130081931A1
Автор: Pinkerton Joseph F.
Принадлежит: CLEAN ENERGY LABS, LLC

A nanoelectromechanical tunneling current switch includes a cantilevered nanofilament including a secured end and an unsecured end and a conductor with a surface substantially perpendicular to a longitudinal axis of the nanofilament when the nanofilament is undeflected. The nanofilament is positioned with respect to the conductor to define a gap between the unsecured end of the nanofilament and the surface of the conductor substantially perpendicular to the longitudinal axis of the nanofilament. The nanofilament and the conductor are electrically connected by a circuit, and a tunneling current is configured to flow from the nanofilament to the surface of the conductor substantially perpendicular to the longitudinal axis of the nanofilament. In other embodiments of the nanoelectromechanical tunneling current switch, an electrically conductive membrane can be utilized in place of, or in addition to, the cantilevered nanofilament. 1. A switch comprising:(i) a cantilevered nanofilament comprising a secured end and an unsecured end;(ii) a conductor with a surface substantially perpendicular to a longitudinal axis of the nanofilament when the nanofilament is undeflected, wherein the nanofilament is positioned with respect to the conductor to define a gap between the unsecured end of the nanofilament and the surface of the conductor substantially perpendicular to the longitudinal axis of the nanofilament; and (a) a tunneling current is configured to flow between the nanofilament and the surface of the conductor substantially perpendicular to the longitudinal axis of the nanofilament; and', '(b) the tunneling current is configured to flow from the nanofilament to the conductor in a direction substantially parallel to the longitudinal axis of the nanofilament when the nanofilament is undeflected., '(iii) a circuit electrically connecting the nanofilament and the conductor, wherein'}2. The switch of claim 1 , wherein the nanofilament is a carbon nanotube.3. The switch of ...

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04-04-2013 дата публикации

Device and method of manipulating particles

Номер: US20130081945A1

Provided is a device and method of manipulating particles. The device includes: a channel for accommodating an electrolyte solution including particles to be manipulated; an anode and cathode for imposing a direct current (DC) electric field on the channel; metal strip(s) attached to an inner wall of the channel and resulting in induced-charge electroosmosis near a surface of the channel; a DC power supply unit for supplying a DC voltage to the anode and the cathode of the channel; control electrodes on both sides of the metal strip(s) to locally tune the induced-charge electroosmosis on the metal strip(s) regardless of the global electric field across the channel; and a DC power supply unit for supplying a DC voltage to the control electrodes.

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04-04-2013 дата публикации

NANOMOTORS AND MOTION-BASED DETECTION OF BIOMOLECULAR INTERACTIONS

Номер: US20130084569A1
Принадлежит:

Techniques and systems are disclosed for detecting biomolecular interactions based on the motion of nanomotors. In one aspect, a method of detecting biomolecular interactions based on a motion of a nanomachine includes functionalizing a nanomachine with a capture probe adapted to interact with biological targets; and detecting a presence of the biological targets in an environment based on a motion of the nanomachine. 1. A method of detecting biomolecular interactions based on a motion of a nanomachine , the method comprising:functionalizing a nanomachine with a capture probe adapted to interact with biological targets; anddetecting a presence of the biological targets in an environment based on a motion of the nanomachine.2. The method of claim 1 , wherein detecting the presence of the biological targets comprises detecting a concentration of the biological targets based on a distance traveled by the functionalized nanomachine.3. The method of claim 1 , wherein detecting the presence of the biological targets in an environment comprises:providing the functionalized nanomachine and nanoparticle tags in the environment to allow the capture probe to form a complex with the nanoparticle tags and the biological targets; anddetecting the complex formation based on the motion of the functionalized nanomachine.4. The method of claim 1 , wherein detecting the complex formation comprises:detecting the motion of the functionalized nanomachine in a nanoparticle-releasing solution, wherein the presence of the released nanoparticle speeds up the motion of the functionalized nanomachine.5. The method of claim 1 , wherein the nanoparticle tags comprise silver nanoparticle tags.6. The method of claim 1 , wherein the nanomachine comprises an anode segment and a cathode segment.7. The method of claim 6 , wherein the anode segment comprises platinum and the cathode comprises gold.8. The method of comprising:wherein the biological targets comprise nucleic acid targets.9. The method of ...

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04-04-2013 дата публикации

MICROWAVE ACCELERATED ASSAYS

Номер: US20130084628A1
Автор: Geddes Chris D.
Принадлежит:

The present invention provides for increasing fluorescence detection in surface assay systems while increasing kinetics of a bioreaction therein by providing low-power microwaves to irradiate metallic materials within the system in an amount sufficient to increase heat thereby affecting the kinetics of a bioreaction therein. 1. A system for shortening the time required to detect or measure the presence of a target molecule in a sample , the system comprising:a metallic material, wherein the metallic material is shaped as particles, nanostructures, islands or colloids;a probe attached to the metallic material for binding with the target molecule in the sample;a sample suspected of containing a target molecule;a source of low power microwave energy that emits energy in the gigahertz frequency range in an amount sufficient to increase the kinetics of a chemical reaction involving at least the binding of the target sample to the probe;a detecting molecule that binds to the target molecule and emits detectably energy when radiated with excitation energy; anda source of excitation energy that emits in the UV to IR range for irradiating the detecting molecule.2. The system according to claim 1 , wherein the metallic material comprises silver or gold.3. The system according to claim 1 , wherein the low power microwave energy is from 30 mwatts to 200 watts.4. The system according to claim 1 , wherein the metallic material is positioned on a substrate.5. The system according to claim 4 , wherein the substrate is glass claim 4 , quartz or a polymeric material.6. The system according to claim 1 , wherein the detecting molecule is an intrinsic fluorophore.7. The system according to claim 1 , wherein the detecting molecule is attached to an extrinsic fluorophore.8. The system according to claim 1 , wherein the metallic material is in the form of a three dimensional matrix claim 1 , wherein metal particles are on the surface of the porous substrate or the metal particles are ...

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04-04-2013 дата публикации

USE OF NANOPARTICLES FOR LABELLING OIL FIELD INJECTION WATERS

Номер: US20130084643A1
Принадлежит: TOTAL SA

The present invention relates to the development of tracer fluids, more generally, that of aqueous liquids, intended to be injected under pressure in an oil reservoir, for example from an injection well up to a production well. 1. A method of study of a solid medium (i.e. an oil reservoir) by diffusion of a fluid through said solid medium , comprising: having average dimensions comprised, in preferred ascending order, between 20 and 200 nm, 20 and 100 nm, 50 and 100 nm, 60 and 80 nm;', 'detectable by means of one or several S signals at dilutions of less than or equal to 10;', 'adapted to form a stable colloidal suspension in a saline medium;', 'at least a portion of which is constituted of a core and a coating provided with an adjustable hydrophilic-lipophilic balance (HLB) and comprising at least one organic and/or organosilicon component., 'injecting, in this solid medium (diffusion), a liquid (injection liquid) comprising a nanoparticle-based tracer;'}recovering the liquid having diffused;analyzing this liquid having diffused to measure the quantity of tracer by detection of the signal or signals S.2. A method according to claim 1 , wherein the core of the nanoparticles contains:at least one material selected from the group consisting of: the semiconductors, noble metals, fluorides, vanadates or rare earth oxides and their mixtures and/or alloys; i. luminescent entities selected from the group consisting of: the semiconductors, oxides, rare earth fluorides or vanadates, organic fluorescent molecules, transition metal ions, rare earth ions connected, or not, to complexing molecules and/or to molecules allowing for enhancing their absorption and their mixtures and/or alloys;', 'ii. optionally, other entities allowing for modifying the luminescence properties and selected from the group consisting of: noble metal particles and their mixtures and/or alloys;', 'iii. and mixtures of (i) and (ii)., 'or a matrix selected from the group of materials consisting of: ...

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11-04-2013 дата публикации

KIT FOR DOT IMMUNOGOLD DIRECTED FILTRATION ASSAY AND USE THEREOF

Номер: US20130089854A1
Автор: Lin Yuan
Принадлежит: XIAN WEITONG BIOSCIENCE LIMITED COMPANY

A kit for dot immunogold directed filtration assay including a dot immunogold directed filtration card, a detection probe labeled by nano colloidal gold or latex beads, a negative standard, a positive standard, and a cleaning solution. 114-. (canceled)15. A kit for dot immunogold directed filtration assay , comprising a dot immunogold filtration card , a detection probe labeled by nano colloidal gold or latex beads , a negative standard , a positive standard , and a cleaning solution , wherein the dot immunogold filtration card is a dot immunogold directed filtration card being capable of allowing a sample to be assayed and a probe labeled by colloidal gold to sequentially filtrate along a region covered by a coated probe.16. The kit for dot immunogold directed filtration assay of claim 15 , wherein the dot immunogold directed filtration card consists of four layers of a surface layer claim 15 , a microporous membrane claim 15 , a filtration limiting layer claim 15 , and a water absorbent pad from top to bottom claim 15 , the surface layer is formed of a water nonabsorbent material and has an opening at a central portion thereof claim 15 , the microporous membrane has an affinity for protein molecules claim 15 , at least one kind of probe is coated on the microporous membrane claim 15 , the filtration limiting layer is formed of a water nonabsorbent material and has an opening at a central portion thereof claim 15 , and the opening of the filtration limiting layer corresponds to the coated probe and has a shape fit to that of the coated probe.17. The kit for dot immunogold directed filtration assay of claim 16 , wherein the filtration limiting layer of the dot immunogold directed filtration card is formed of PVC claim 16 , PE claim 16 , PP claim 16 , PS claim 16 , ABS plastic claim 16 , a double side adhesive claim 16 , or a waterproof coating.18. The kit for dot immunogold directed filtration assay of claim 15 , wherein the dot immunogold directed filtration card ...

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18-04-2013 дата публикации

Method of activation of noble metal for measurement of glucose and associated biosensor electrode

Номер: US20130092526A1
Принадлежит: CPFILMS INC.

An electrochemical glucose biosensor comprising two electrodes with at least one of electrodes having both a metallic layer and a non-metallic layer in direct contact with the metallic layer. The metallic layer is comprised of a noble metal element. A glucose reactive strip connects the first electrode and the second electrode. 1. An electrochemical glucose biosensor comprising: a metallic layer comprising a noble metal element; and', 'a non-metallic electrically conductive layer disposed in direct contact with the metallic layer;, 'a first electrode comprising a non-conducting and chemically inert substrate having disposed thereon an electrically conductive layer, the electrically conductive layer comprisinga second electrode comprising a non-conducting and chemically inert substrate having disposed thereon an electrically conductive layer, the electrically conductive layer comprising a metallic layer comprising a noble metal element; and a glucose reactive strip connecting the first electrode and the second electrode.2. The electrochemical glucose biosensor of wherein the noble metal element of the first electrode is palladium.3. The electrochemical glucose biosensor of wherein the thickness of the metallic layer comprising noble metal of both the first and second electrodes is between about 10 nanometers and about 10 microns.4. The electrochemical glucose biosensor of wherein the thickness of the metallic layer comprising noble metal of both the first and second electrodes is between about 10 nanometers and about 50 nanometers.5. The electrochemical glucose biosensor of wherein the thickness of the metallic layer comprising noble metal of both the first and second electrodes is between about 20 nanometers and about 30 nanometers.6. The electrochemical glucose biosensor of wherein the thickness of the non-metallic electrically conductive layer is between about 1 nanometer and about 10 nanometers.7. The electrochemical glucose biosensor of wherein the glucose ...

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18-04-2013 дата публикации

THREE-ELECTRODE LINEAR AND BENDING POLYMERIC ACTUATOR

Номер: US20130093287A1

A polymeric actuator includes a first and a second electrode layer (), both containing electrically conductive material and able to change size in at least one direction of deformation under the action of charge injection or ion intercalation. A solid polymer electrolyte layer () is interposed between the first and the second electrode layer, in which the solid polymer electrolyte layer is electrically insulating and ionically conductive. The actuator is able to deform by the action of the dimensional changes of the first and second electrode layer. The actuator further includes a passive electrode () immersed in the solid electrolyte layer to be electrically insulated relative to the first and second electrode layer, in which the passive electrode is electrically conductive and elastically deformable material, so as to support mechanically the deformations of the actuator induced by the dimensional changes of the first and second electrode layer. 1. A polymeric actuator comprising{'b': 2', '3, 'a first and a second electrode layer (, ), both containing an electrically conductive material and able to change size along at least one direction of deformation as a result of charge injection or ion intercalation, and'}{'b': '4', 'a solid polymer electrolyte layer () interposed between said first and the second electrode layers, where said solid polymer electrolyte layer is an electrical insulator and a ionic conductor,'}where said actuator is able to alter its shape as a result of dimensional changes of the said first and second electrode layers,{'b': '5', 'characterized in that said actuator comprises a passive electrode () immersed in the solid polymer electrolyte layer in order to be electrically insulated with respect to the said first and second electrode layers, where the said passive electrode is made of electrically conductive and elastically deformable material, in order to mechanically comply with deformations of the actuator induced by the dimensional changes ...

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18-04-2013 дата публикации

Probe having nano-fingers

Номер: US20130094020A1
Автор: Zhiyong Li
Принадлежит: Hewlett Packard Development Co LP

A probe for use in a sensing application includes an elongate body having a first end and a free end, wherein the first end is to be attached to a support. The probe also includes a plurality of nano-fingers having respective bases and tips, wherein each of the plurality of nano-fingers is attached to the free end and is composed of a flexible material, and wherein the plurality of nano-fingers are collapsed toward each other such that the tips of the plurality of nano-fingers are substantially in contact with each other.

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18-04-2013 дата публикации

Reagents and methods for phosphorylation/dephosphorylation analyses

Номер: US20130095502A1
Принадлежит: PURDUE RESEARCH FOUNDATION

Disclosed herein are reagents that include a moiety that includes a metal such as titanium and that readily binds to phosphorylated molecules the reagents also include at least one moiety that produces a signal or that binds to a molecule that produces a signal. The reagent may also include a moiety that binds to a larger molecule or to a surface. Some forms of the reagent include a dendrimer that can simultaneously bind to multiple metal moieties that include a metal such as titanium and multiple moieties that can be used to detected bound molecules. These reagents can be used in detection and/or measurement and/or at least partial purification of phosphorylated molecules. These reagents and methods using them are used to analyze proteins, polypeptides, nucleic acids, phospholipids and the like. They are readily adapted for use in gels, blots, plate based high through put assays and for mass spectrometry.

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25-04-2013 дата публикации

Novel Phosphorylation of Cardiac Troponin I as a Monitor for Cardiac Injury

Номер: US20130101606A1
Принадлежит:

This invention relates to novel phosphorylation sites in cardiac Troponin I that are associated with the onset of heart failure. The phosphorylation sites, i.e., serine 5, tyrosine 26, threonine 51, serine 166, threonine 181 and/or serine 199, can be used as biomarkers for (i) identifying subjects at risk for the development of heart failure, (ii) treating subjects having a higher than normal level of the biomarker, and (iii) monitoring therapy of a subject at risk for the development of heart failure. Also described are antibodies, reagents, and kits for carrying out a method of the present invention. 1. An antibody that specifically recognizes phosphorylated serine 5 , tyrosine 26 , threonine 51 , serine 166 , threonine181 and/or serine 199 in cardiac Troponin I.2. The antibody of claim 1 , wherein the antibody is a monoclonal antibody.3. The antibody of claim 1 , wherein the antibody is a polyclonal antibody.4. The antibody of claim 1 , wherein the antibody is labeled.5. The antibody of claim 4 , wherein the label is a fluorescent label claim 4 , a moiety that binds another reporter ion claim 4 , a heavy ion claim 4 , a gold particle claim 4 , or a quantum dot.6. A kit for identifying a subject at risk for developing heart failure claim 4 , comprising at least one agent that detects the phosphorylation state of a cardiac Troponin I protein at serine 5 claim 4 , tyrosine 26 claim 4 , threonine 51 claim 4 , serine 166 claim 4 , threonine181 and/or serine 199.7. The kit of claim 6 , wherein the agent is an antibody that recognizes the phosphorylation state of serine 5 claim 6 , tyrosine 26 claim 6 , threonine 51 claim 6 , serine 166 claim 6 , threonine181 and/or serine 199.8. The kit of claim 6 , wherein the agent is an antibody that recognizes un- claim 6 , mono claim 6 , di- claim 6 , and/or tri-phosphorylated serine 5 claim 6 , tyrosine 26 claim 6 , threonine 51 claim 6 , serine 166 claim 6 , threonine181 and/or serine 199.9. The kit of claim 6 , wherein the ...

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25-04-2013 дата публикации

Particle matrix for storage of biomolecules

Номер: US20130101981A1
Принадлежит: Individual

Matrices for manipulation of biopolymers, including the separation, purification, immobilization and archival storage of biopolymers is disclosed.

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25-04-2013 дата публикации

MULTI-LEG LUMINESCENT NANOPARTICLES, MULTI-LEG LUMINESCENT NANOPARTICLE COMPOUNDS AND VARIOUS APPLICATIONS

Номер: US20130101999A1
Принадлежит: NANOAXIS, LLC

Multi-leg luminescent nanoparticles (“MLN's”) that can be paired to other MLN's as well s biological molecules to film branched multi-leg luminescent nanoparticles (“BMLN's) that can be used in biological multiplexing applications, imaging applications, biological detection applications and other biological applications. 1. A multi-leg luminescent nanoparticle , comprising:one or more legs extending from a base wherein the one or more legs and the base comprise a luminescent semiconductor nanoparticle;a shell that coats the one or more legs and the base; anda pairing moiety connected to the shell coated one or more legs and base, and configured to connect to an targeting molecule.2. The nanoparticle of claim 1 , wherein the base and one or more legs are a semiconductor or a III-V semiconductor.3. The nanoparticle of claim 2 , wherein the base and one or more legs are a II-VI semiconductor.4. The nanoparticle of claim 2 , wherein the base and one or more legs are a semiconductor.5. The nanoparticle of claim 3 , wherein the semiconductor is MgS claim 3 , MgSe claim 3 , MgTe claim 3 , CaS claim 3 , CaSe claim 3 , CaTe claim 3 , SrS claim 3 , SrSe claim 3 , SrTe claim 3 , BaS claim 3 , BaSe claim 3 , BaTe claim 3 , ZnS claim 3 , ZnSe claim 3 , ZnTe claim 3 , CdS claim 3 , CdSe claim 3 , CdTe claim 3 , HgS claim 3 , HgSe claim 3 , or HgTe.6. The nanoparticle of claim 4 , wherein the semiconductor is GaAs claim 4 , InGaAs claim 4 , InP claim 4 , or InAs.7. The nanoparticle of claim 1 , wherein the shell semiconductor is a II-VI semiconductor or a III-V semiconductor.8. The nanoparticle of claim 7 , wherein said shell is a II-VI semiconductor or a III-V semiconductor.9. The nanoparticle of claim 8 , wherein the semiconductor is MgS claim 8 , MgSe claim 8 , MgTe claim 8 , CaS claim 8 , CaSe claim 8 , CaTe claim 8 , SrS claim 8 , SrSe claim 8 , SrTe claim 8 , BaS claim 8 , BaSe claim 8 , BaTe claim 8 , ZnS claim 8 , ZnSe claim 8 , ZnTe claim 8 , CdS claim 8 , CdSe claim 8 , ...

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02-05-2013 дата публикации

Real-time redox sequencing

Номер: US20130109577A1
Принадлежит: Pacific Biosciences of California Inc

Real time redox sequencing methods, devices, and systems are described. Arrays of redox devices comprising one or two electrodes are used to provide sequence information about a template nucleic acid in a polymerase-template complex bound proximate to the electrode(s). A sequencing reaction mixture comprising nucleotide analogs comprising redox labels is introduced to the array of redox devices under conditions of polymerase mediated nucleic acid synthesis. The time sequence of incorporation of nucleotide analogs is determined by electrochemically identifying the redox labels of the nucleotide analogs that are incorporated into the growing strand.

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09-05-2013 дата публикации

QUANTUM DOT-BASED OPTICAL SENSORS FOR RAPID DETECTION AND QUANTITATIVE ANALYSIS OF BIOMOLECULES AND BIOLOGICAL MATERIALS

Номер: US20130115713A1
Принадлежит:

The invention generally relates to detection and analysis of biological materials. In particular; the invention relates to quantum dot-based optical, sensors and methods for rapid detection and quantitative analysis of various biomolecules and biological materials, such as nucleic acids, proteins, cells, etc. 1. An optical biomolecular sensor for detecting a target biological material , comprising:(a) an inorganic semiconductor nanocrystal capable of fluorescing at a pre-selected wavelength range upon excitation, wherein the semiconductor nanocrystal has a surface allowing aqueous solubility of the semiconductor nanocrystal;(b) a biomolecular probe having an affinity to the target biological material; and(c) a linkage moiety associated with the semiconductor nanocrystal and with the biomolecular probe such that binding of the biomolecular probe with the target biological material results in an optically detectable change in the fluorescence emission spectrum of the semiconductor nanocrystal without employing a second fluorophore other than the semiconductor nanocrystal.2. The optical biomolecular sensor of claim 1 , wherein the optically detectable change in the fluorescence emission spectrum of the semiconductor nanocrystal comprises a change in the fluorescence emission intensity claim 1 , a change in the blinking rate of the emitted light or a shift in the peak emission wavelength.3. The optical biomolecular sensor of claim 1 , wherein a single biomolecular probe is linked to a single semiconductor nanocrystal.4. The optical biomolecular sensor of claim 1 , wherein the semiconductor nanocrystal is single crystalline ZnSe.5. The optical biomolecular sensor of claim 1 , wherein the semiconductor nanocrystal is single crystalline ZnSe doped with ions selected from the group consisting of Cr claim 1 , Mn claim 1 , Fe claim 1 ,Co claim 1 , Ni claim 1 , and Cu.6. The optical biomolecular sensor of claim 5 , wherein the semiconductor nanocrystal. is single crystalline ...

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16-05-2013 дата публикации

KIT INCLUDING SEQUENCE SPECIFIC BINDING PROTEIN AND METHOD AND DEVICE FOR DETERMINING NUCLEOTIDE SEQUENCE OF TARGET NUCLEIC ACID

Номер: US20130122577A1
Принадлежит: SAMSUNG ELECTRONICS CO., LTD.

Provided are kits for determining a nucleotide sequence of a target nucleic acid, the kit including at least one sequence specific binding protein and a detectable tag. In accordance with a kit for determining a nucleotide sequence of a target nucleic acid according to one exemplary embodiment and a method and device for determining a nucleotide sequence of a target nucleic acid, the nucleotide sequence of the target nucleic acid may be more efficiently determined. 1. A kit for determining a nucleotide sequence of a target nucleic acid comprising: at least one sequence specific binding protein and a detectable tag.2. The kit of claim 1 , wherein the target nucleic acid has a length of 1 kb to 10 Mb.3. The kit of claim 1 , wherein the target nucleic acid is double stranded.4. The kit of claim 1 , wherein the sequence specific binding protein comprises at least one motif selected from the group consisting of a zinc finger motif claim 1 , a helix-turn-helix motif claim 1 , a helix-loop-helix motif claim 1 , a leucine zipper motif claim 1 , a nucleic acid-binding motif of restriction endonuclease claim 1 , and a combination thereof.5. The kit of claim 1 , wherein the detectable tag comprises at least one selected from the group consisting of a colored bead claim 1 , a chromophore claim 1 , a fluorescent material claim 1 , a fluorescent protein claim 1 , a phosphorescent material claim 1 , an electrically detectable molecule claim 1 , a molecule providing modified fluorescence-polarization or modified light-diffusion claim 1 , a quantum dotand a combination thereof.6. The kit of claim 5 , wherein the fluorescent protein is selected from the group consisting of a yellow fluorescent protein (YFP) claim 5 , a green fluorescent protein (GFP) claim 5 , a red fluorescent protein (RFP) and a combination thereof.7. The kit of claim 1 , wherein the detectable tag is linked to the sequence specific binding protein by a linker.8. A gene construct comprising a polynucleotide ...

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16-05-2013 дата публикации

Methods. particles, and assay kits for identifying presence of biological parameters

Номер: US20130123145A1
Принадлежит: NanoAxis LLC

Multiplexed assays are disclosed for detection of duster differentiation 4 (CD4) glycoprotein expressed on the cell surface of I-helper cells, monocytes, macrophages, and dendritic cells; cluster differentiation 25 (CD25), a type transmembrane protein present on activated T-cells, activated B-cells, thymocytes, myeloid precursors, and oligodendrocytes; and Forkhead box P3 (FOXP3), an intracellular protein involved in immune system responses in cell cultures, tissues samples, humans, and biological samples. The multiplexed assays can be used to detect 1r-cells, activated I-cells, and other similar cell types (e.g. natural T regulatory cells, adaptive/induced T regulatory T cells). The multiplexed assays employ quantum dots of various shapes, types, compositions, coatings, sizes, ligands and other such characteristics.

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16-05-2013 дата публикации

Simultaneous synthesis of temperature-tunable peptide and gold nanoparticle hybrid spheres

Номер: US20130123466A1
Автор: Hor-Gil Hur, Jungok Kim

The present invention relates to a novel synthesis of peptide-gold nanoparticle hybrid spheres comprising a step of forming a hybrid structure by inducing self-assembly of a gold-binding peptide, and forming a gold nanoparticle in the structure at the same time. According to the present invention, size of the structure can be controlled according to temperature, and it can be used for various biomedical and electronic applications using the structure.

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23-05-2013 дата публикации

PIEZOELECTRIC DEVICE OF POLYMER

Номер: US20130127299A1
Принадлежит: SAMSUNG ELECTRO-MECHANICS CO., LTD.

The present invention relates to a piezoelectric device of a multi-layered structure on which first electrodes and second electrodes are sequentially stacked on a piezoelectric polymer and single surfaces or both surfaces of piezoelectric polymer. 1. A piezoelectric device with a multi-layered structure , comprising:a piezoelectric polymer; anda plurality of first electrodes and a plurality of second electrodes stacked sequentially a single surface or both surface of the piezoelectric polymer.2. The piezoelectric device according to claim 1 , wherein the piezoelectric polymer is polyvinylidene fluoride (PVDF) and polyvinylidene florodide-trifluoroethylene (PVDF-TrFE).3. The piezoelectric device according to claim 1 , wherein the first electrodes are graphene or a graphene composite including the same.4. The piezoelectric device according to claim 3 , wherein the graphene composite is made of a material obtained by mixing the graphene with at least one type material selected from a group consisting of a metal nano wire claim 3 , a metal nano particle claim 3 , a carbon nano tube and conductive polymer.5. The piezoelectric device according to claim 1 , wherein the second electrodes are transparent electrodes or opaque electrodes.6. The piezoelectric device according to claim 5 , wherein the transparent electrode is a grid electrode.7. The piezoelectric device according to claim 5 , wherein the opaque electrodes are obtained by coating metal on a whole surface.8. The piezoelectric device according to or claim 5 , wherein the metal is at least one powder claim 5 , a nano wire or a nano particle selected from a group consisting of Au claim 5 , Cu claim 5 , Al and Ag.9. The piezoelectric device according to claim 1 , further comprises:a plurality of third electrodes on the second electrodes.10. The piezoelectric device according to claim 9 , wherein the third electrodes are graphene or graphene composites including the same.11. The piezoelectric device according to claim ...

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06-06-2013 дата публикации

Pressure sensor having nanostructure and manufacturing method thereof

Номер: US20130140611A1

The present disclosure relates to a pressure sensor having a nanostructure and a method for manufacturing the same. More particularly, it relates to a pressure sensor having a nanostructure attached on the surface of the pressure sensor and thus having improved sensor response time and sensitivity and a method for manufacturing the same. The pressure sensor according to the present disclosure having a nanostructure includes: a substrate; a source electrode and a drain electrode arranged on the substrate with a predetermined spacing; a flexible sensor layer disposed on the source electrode and the drain electrode; and a nanostructure attached on the surface of the flexible sensor layer and having nanosized wrinkles.

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13-06-2013 дата публикации

ELECTRON MULTIPLIER DETECTOR FORMED FROM A HIGHLY DOPED NANODIAMOND LAYER

Номер: US20130146778A1
Принадлежит: PHOTONIS FRANCE

A system for detecting electromagnetic radiation or an ion flow, including an input device for receiving the electronic radiation or the ion flow and emitting primary electrons in response, a multiplier of electrons in transmission, for receiving the primary electrons and emitting secondary electrons in response, and an output device for receiving the secondary electrons and emitting an output signal in response. The electron multiplier includes at least one nanocrystalline diamond layer doped with boron in a concentration of higher than 5·10cm. 116-. (canceled)17. A system for detecting an electromagnetic radiation or an ion flow , comprising:an input device, for receiving the radiation or an ion flow and emitting primary electrons in response;a multiplier of electrons in transmission for receiving the primary electrons and emitting secondary electrons in response; andan output device, for receiving the secondary electrons and emitting an output signal in response,{'sup': 19', '−3, 'wherein the electron multiplier comprises at least one nanocrystalline diamond layer doped with boron in a concentration of higher than 5·10cm.'}18. A detection system according to claim 17 , wherein the nanocrystalline diamond layer has a boron doping concentration higher than 2·10cm.19. A detection system according to claim 17 , wherein the thickness of the nanocrystalline diamond layer is between 0.1 μm and 10 μm.20. A detection system according to claim 17 , wherein the nanocrystalline diamond layer is formed by chemical vapour deposition.21. A detection system according to claim 17 , wherein the nanocrystalline diamond layer comprises an upstream face for receiving incident electrons claim 17 , and a downstream face for emitting secondary electrons in response claim 17 , the upstream face comprising a hole collection electrode configured to be taken to an electrical potential.22. A detection system according to claim 21 , wherein the collection electrode is situated at an edge of ...

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13-06-2013 дата публикации

Optical reporter compositions

Номер: US20130149706A1
Принадлежит: APDN BVI Inc

This invention provides compositions that have a light emitting reporter linked to biomolecules, preferably, nucleotide oligomers. The light reporter particles are silylated and functionalized to produce a coated light reporter particle, prior to covalently linking the biomolecules to the light reporter particle. The light reporter particles of the invention can be excited by a light excitation source such as UV or IR light, and when the biomolecule is DNA, the attached DNA molecule(s) are detectable by amplification techniques such as PCR.

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20-06-2013 дата публикации

ELECTRODE PATTERN OF TOUCH PANEL AND FORMING METHOD FOR THE SAME

Номер: US20130155011A1
Принадлежит: LG INNOTEK CO., LTD.

The present invention relates to an electrode pattern of a touch panel and a forming method of the electrode pattern of a touch panel. The electrode pattern of a touch panel according to the present invention includes a plurality of electrode pattern cells which are arranged on a substrate in a space, a dielectric layer formed on the electrode pattern cell, and a bridge electrode which is formed on the dielectric layer by using conductive material of black color and connects the electrode pattern cells. 1. A forming method of an electrode pattern of a touch panel , comprising:forming a plurality of electrode pattern cells formed to each other in a space on a substrate;forming a dielectric layer on the electrode pattern cell; andforming a bridge electrode which is formed on the dielectric layer by using conductive material of black color and connects the electrode pattern cells.2. The forming method of an electrode pattern of a touch panel of claim 1 , wherein the bridge conductive is formed with a metal oxide claim 1 , nitride or fluoride as a blackened metal material.3. The forming method of an electrode pattern of a touch panel of claim 1 , wherein the bridge conductive is blackened claim 1 , corresponding to the luminosity of the substrate claim 1 , the electrode pattern cell or the dielectric layer.4. The forming method of an electrode pattern of a touch panel of claim 2 , wherein the metal material is one of Al claim 2 , Au claim 2 , Ag claim 2 , Sn claim 2 , Cr claim 2 , Ni claim 2 , Ti and Mg.5. The forming method of an electrode pattern of a touch panel of claim 1 , wherein the bridge conductive is formed with Carbon Nano Tube.6. The forming method of an electrode pattern of a touch panel of claim 1 , wherein the bridge conductive is formed as a plurality of layers formed by using a plurality of conductive materials.7. The forming method of an electrode pattern of a touch panel of claim 6 , wherein among the plurality of layers of the bridge conductive claim ...

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20-06-2013 дата публикации

Pacemakers and pacemaker electrodes

Номер: US20130158644A1

A pacemaker is provided. The pacemaker includes an electrode line having a lead and an electrode. The electrode includes a carbon nanotube composite structure having a matrix and at least one carbon nanotube structure located in the matrix. A first end of each carbon nanotube structure protrudes out of a first surface of the matrix for stimulating the human tissue, and a second end of each carbon nanotube structure protrudes out of a second surface of the matrix to electrically connect to the lead.

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27-06-2013 дата публикации

Resistive memory

Номер: US20130163310A1
Автор: Bao Tran
Принадлежит: Individual

A memory device includes an upper conductive layer, a lower conductive layer, and a resistive, optical or magnetic matrix positioned between the upper and lower conductive layers.

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27-06-2013 дата публикации

Methods and Compositions for Generating Bioactive Assemblies of Increased Complexity and Uses

Номер: US20130164816A1
Принадлежит: IBC Pharmaceuticals Inc

The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-and-lock (DNL) methodology, which takes advantage of the specific binding interaction between dimerization and docking domains (DDD) and anchoring domains (AD) to form the assembly. In various embodiments, one or more effectors may be attached to a DDD or AD sequence. Complementary AD or DDD sequences may be attached to an adaptor module that forms the core of the bioactive assembly, allowing formation of the assembly through the specific DDD/AD binding interactions. Such assemblies may be attached to a wide variety of effector moieties for treatment, detection and/or diagnosis of a disease, pathogen infection or other medical or veterinary condition.

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27-06-2013 дата публикации

System and method for sensing intraocular pressure

Номер: US20130165762A1

Systems and methods of sensing intraocular pressure are described. In one embodiment, a miniaturized IOP monitoring system is provided using a nanophotonics-based implantable IOP sensor with remote optical readout that can be adapted for both patient and research use. A handheld detector optically excites the pressure-sensitive nanophotonic structure of the IOP-sensing implant placed in the anterior chamber and detects the reflected light, whose optical signature changes as a function of IOP. Optical detection eliminates the need for large, complex LC structures and simplifies sensor design. The use of nanophotonic components improves the sensor's resolution and sensitivity, increases optical readout distance, and reduces its size by a factor of 10-30 over previously reported implants. Its small size and convenient optical readout allows frequent and accurate self-tracking of IOP by patients in home settings. Embodiments can also be used to monitor colonies of animals to support glaucoma research and drug discovery.

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27-06-2013 дата публикации

ELECTRICAL-MECHANICAL COMPLEX SENSOR FOR NANOMATERIALS

Номер: US20130167272A1

Disclosed is an electrical-mechanical complex sensor for nanomaterials, including: a detector having a piezoelectric film therein, for measuring a mechanical property of a nanomaterial when a bending or tensile load is applied to the nanomaterial; a first detection film formed at an end of the detector to measure the mechanical property and an electrical property of the nanomaterial) in real time at the same time, when the nanomaterial contacts the first detection film; and a support to which one end of the detector is integrally connected, for supporting the detector. 1. An electrical-mechanical complex sensor for nanomaterials , comprising:{'b': 20', '35', '35, 'a detector () having a piezoelectric film therein, for measuring a mechanical property of a nanomaterial () when a bending or tensile load is applied to the nanomaterial ();'}{'b': 21', '20', '35', '35', '21, 'i': a', 'a, 'a first detection film () formed at an end of the detector () to measure the mechanical property and an electrical property of the nanomaterial () in real time at the same time, when the nanomaterial () contacts the first detection film (); and'}{'b': 10', '20', '20, 'a support () to which one end of the detector () is integrally connected, for supporting the detector (),'}{'b': 10', '11', '14', '35', '15', '21', '21', '35, 'i': b', 'a, 'wherein the support () comprises first to fourth electrodes ( to ) constituting a Wheatstone bridge circuit to measure the load applied to the nanomaterial (), and a fifth electrode () haying a second detection film () at an end thereof to be connected to a first detection film (), for measuring an electrical property of the nanomaterial ().'}220222324232224. The electrical-mechanical complex sensor of claim 1 , wherein the detector () has a structure in which a silicon oxide film () claim 1 , an Au layer () claim 1 , a piezoelectric film () formed of a piezoelectric material claim 1 , an Au layer () claim 1 , and a silicon oxide film () are laminated ...

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04-07-2013 дата публикации

System and Method for Accelerating Interacting Nanostructures

Номер: US20130168904A1
Автор: Fabrizio Pinto
Принадлежит: Fabrizio Pinto

A core is moved within a surrounding nanotube shell by modulating the magnitude of the dispersion force therebetween along successive portions of the nanotube shell.

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04-07-2013 дата публикации

METHODS FOR DETECTING PLASTICIZERS

Номер: US20130172214A1
Автор: Ye Bangce, ZHANG Min

Nanoparticles having one or more attached sensing moieties including uridine 5′-triphosphate (UTP) and deoxythymidine 5′-triphosphate (dTTP), are disclosed herein. These nanoparticles can, for example, be used for detection of plasticizers, such as phthalates, in the sample. Methods, kits and apparatuses using these nanoparticles for detecting plasticizers in a sample are also disclosed herein. 1. A method for detecting a plasticizer in a sample , the method comprising:providing a sample suspected of containing a plasticizer;providing a plurality of nanoparticles having one or more attached sensing moieties, wherein the sensing moiety comprises one or more uridine 5′-triphosphate (UTP) groups, uridine 5′-diphosphate (UDP) groups, uridine monophosphate (UMP) groups, 2′-deoxythymidine 5′-triphosphate (dTTP) groups, 2′-deoxythymidine 5′-diphosphate (dTDP) groups, or deoxythymidine 5′-monophosphate (dTMP) groups;contacting the sample with the plurality of nanoparticles in the presence of a crosslinker to form a mixture;maintaining the mixture under conditions allowing the crosslinker to bind the nanoparticles and any plasticizer present in the sample to form a nanoparticle aggregate; anddetecting the nanoparticle aggregate.2. The method of claim 1 , wherein the nanoparticles are metallic.3. The method of claim 1 , wherein the nanoparticles are gold nanoparticles claim 1 , silver nanoparticles claim 1 , platinum nanoparticles claim 1 , aluminum nanoparticles claim 1 , palladium nanoparticles claim 1 , copper nanoparticles claim 1 , cobalt nanoparticles claim 1 , indium nanoparticles claim 1 , nickel nanoparticles claim 1 , or combinations thereof.4. (canceled)5. The method of claim 1 , wherein the nanoparticles are gold nanoparticles claim 1 , silver nanoparticles claim 1 , quantum dots claim 1 , carbon nanotubes claim 1 , graphene oxides claim 1 , or combinations thereof.6. The method of claim 1 , wherein the nanoparticles have an average diameter of about 12 nm to ...

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11-07-2013 дата публикации

TOUCH SENSOR AND TOUCH PANEL INCLUDING THE SAME

Номер: US20130176072A1
Принадлежит: SAMSUNG ELECTRONICS CO., LTD.

A touch sensor using a graphene diode and/or a touch panel including the touch sensor. The touch sensor includes a first sensing electrode configured to sense a touch; a first output line configured to transmit an electrical signal; and a first diode device including a first control terminal connected to the first sensing electrode, a first anode terminal connected to a voltage application unit, and a first cathode terminal connected to the first output line. 1. A touch sensor for transforming a touch of a user into an electrical signal , the touch sensor comprising:a first sensing electrode configured to sense the touch;a first output line configured to transmit the electrical signal; anda first diode device including a first control terminal connected to the first sensing electrode, a first anode terminal connected to a voltage application unit, and a first cathode terminal connected to the first output line.2. The touch sensor of claim 1 , wherein the first sensing electrode is configured to increase or decrease a voltage based on the touch claim 1 , the first diode device is configured to turn on or off based on the voltage and the electrical signal is generated by the turned-on or turned-off first diode device.3. The touch sensor of claim 1 , further comprising:a capacitive device connected to the first diode device; anda switching device connected between the capacitive device and the first output line.4. The touch sensor of claim 3 , wherein the capacitive device is configured to store the electrical signal generated by the first diode device claim 3 , andwherein the switching device is configured to transmit the electrical signal stored in the capacitive device to the first output line in response to a scan signal.5. The touch sensor of claim 3 , wherein the switching device includes a transistor device.6. The touch sensor of claim 5 , wherein the transistor device includes a gate terminal configured to receive the scan signal claim 5 , a first source or ...

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18-07-2013 дата публикации

Optoelectrical vapor sensing

Номер: US20130183766A1
Автор: Ling Zang, Yanke Che

A chemical sensor can comprise a nanofiber mass of p-type nanofibers having a HOMO level greater than −5.0 eV. Additionally, the chemical sensor can comprise oxygen in contact with the p-type nanofibers. Further, the chemical sensor can comprise a pair of electrodes in electrical contact across the nanofiber mass, where the p-type nanofibers conduct an electric current that decreases upon contact with an amine compound.

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25-07-2013 дата публикации

FREQUENCY MULTIPLEXED SUPERCONDUCTING NANOWIRE PHOTON DETECTORS

Номер: US20130187051A1
Принадлежит: Massachusetts Institute of Technology

A photon detection system with improved high-speed performance. An array of photon detectors is provided, providing transient responses that indicate both a time and a location of photon detection. Each photon detector may use a superconducting nanowire, arranged as part of a resonant cell to have a unique resonant frequency. Upon detection of even a single photon, a resonant cell may create a transient response comprising its unique resonant frequency. The transient responses may be combined on a single readout line, allowing identification of the photon detection location based on a detected frequency component read out. The electrical properties within resonant cells, as well as the connections between different resonant cells, may be configured to produce different transient responses. For example, resonant cells may be configured to produce a transient response having multiple pulses, which may separately indicate a time and a location of a photon detection. 1. A photon detection system , comprising:an output line;a plurality of resonant cells coupled to the output line, each resonant cell comprising a nanowire, wherein each of the plurality of resonant cells is configured to provide a different resonant frequency; anda frequency detector coupled to the output line, the frequency detector configured to detect on the output line transient responses of the plurality of resonant cells.2. The photon detection system of claim 1 , wherein:the frequency detector is further configured to indicate a frequency component and a time of initiation of a transient response of any of the plurality of resonant cells.3. The photon detection system of claim 2 , further comprising:a digital code generation circuit coupled to the frequency detector, the digital code generator configured to generate a digital code representing a combination of a value selected based on a detected frequency component and a value indicative of a time of initiation of the transient response.4. The ...

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25-07-2013 дата публикации

Methods And Systems For Long Distance Tagging, Tracking, And Locating Using Wavelength Upconversion

Номер: US20130190192A1
Автор: Lowe Adam J.
Принадлежит: SRC, INC.

Methods and systems for plasmonically enhanced bionanoantennas for tagging, tracking, and locating targets of interest at long distances in both day and nighttime conditions. The nanoantennas are used to tag a target of interest and emit a wavelength to impart a unique biometric signature. The nanoantennas are detectable by selectively harvesting and plasmonically enhancing incident light in the visible region, then upconverting that energy through an activated phosphor. 1. A nucleic acid tag comprising:an agglomerated plurality of nanoparticle nucleotide-support platforms each attached to a plurality of nucleic acid molecules, each of said nucleic acid molecules comprising identifying information, wherein a spacer is located between said nanoparticle nucleotide-support platform and said identifying information;an upconverting fluorescent material; andan encapsulant surrounding said agglomerated plurality of nanoparticle nucleotide-support platforms and said plurality of nucleic acid molecules;wherein when the nucleic acid tag is exposed to electromagnetic radiation of a first wavelength, the upconverting fluorescent material emits electromagnetic radiation of a second wavelength, said second wavelength being shorter than said first wavelength.2. The nucleic acid tag of claim 1 , further comprising:a plasmonic enhancer.3. The nucleic acid tag of claim 1 , wherein the encapsulant is adapted to prevent degradation of the plurality of nucleic acid molecules.4. The nucleic acid tag of claim 1 , wherein each of the plurality of nucleic acid molecules is composed of nucleotides selected from the group consisting of ribonucleotides claim 1 , deoxyribonucleotides claim 1 , and nucleotide analogues.5. The nucleic acid tag of claim 1 , wherein each of the plurality of nucleic acid molecules is an oligonucleotide.6. The nucleic acid tag of claim 1 , wherein each of the plurality of nucleic acid molecules is genomic deoxyribonucleic acid ranging from two nucleotides to the ...

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01-08-2013 дата публикации

Methods Of Nucleic Acid Analysis

Номер: US20130196323A1

In one aspect, methods of nucleic acid analysis are described herein. In some embodiments, a method of nucleic acid analysis comprises providing a mixture of differing single-strand nucleic acid segments, including unamplified single-strand nucleic acid segments, combining the mixture of differing single-strand nucleic acid segments with a single-strand nucleic acid probe, contacting the mixture with a membrane comprising at least one nanopore, applying an electric field across the nanopore, and measuring change in current through the nanopore during one or more nucleic acid translocation events.

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08-08-2013 дата публикации

Multifunctional nanoplatforms for fluorescence imaging and photodynamic therapy developed by post-loading photosensitizer and fluorophore to polyacrylamide nanoparticles

Номер: US20130202525A1

A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and a postloaded imaging agent and methods for making and using same.

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15-08-2013 дата публикации

Functionalized Carbon Nanotube Sheets for Electrochemical Biosensors and Methods

Номер: US20130209807A1
Автор: Chatterjee Jhunu

Electrodes and methods for making electrodes including modified carbon nanotube sheets are provided. The carbon nanotube sheets can be modified with metal particles or at least one mediator titrant. The electrodes can be disposed on a glassy carbon electrode to modify the glassy carbon electrode. Methods are provided that include forming a suspension of carbon nanotubes and metal particles or at least one mediator titrant, and filtering the suspension to form a modified carbon nanotube sheet. 1. A method for making an electrode comprising:forming a suspension comprising carbon nanotubes at least one mediator titrant;filtering the suspension to obtain a modified carbon nanotube sheet; andarranging the modified carbon nanotube sheet on a glassy carbon electrode.2. The method of claim 1 , wherein the at least one mediator titrant comprises methylene blue claim 1 , thionine claim 1 , or PMS.3. The method of claim 1 , wherein the carbon nanotube sheets comprise SWNTs claim 1 , MWNTs claim 1 , carbon nanofibers claim 1 , or a combination thereof.4. The method of claim 1 , wherein the carbon nanotubes are acid-functionalized claim 1 , amino-functionalized claim 1 , acid-modified claim 1 , or a combination thereof.5. The method of claim 1 , wherein the carbon nanotubes comprise carboxyl groups.6. An electrode comprising a carbon nanotube sheet modified with at least one mediator titrant.7. The electrode of claim 6 , further comprising a glassy carbon electrode claim 6 , wherein the carbon nanotube sheet is disposed on the glassy carbon electrode.8. The electrode of claim 6 , wherein the at least one mediator titrant comprises methylene blue claim 6 , thionine claim 6 , or PMS.9. An electrode comprising a carbon nanotube sheet modified with metal particles.10. The electrode of claim 9 , wherein the metal particles are non-covalently bound to the carbon nanotube sheet.11. The electrode of claim 9 , wherein the metal particles comprise nanoparticles.12. The electrode of claim ...

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15-08-2013 дата публикации

SILICA NANOPARTICLES WITH AGGREGATION INDUCED EMISSION CHARACTERISTICS AS FLUORESCENT BIOPROBE FOR INTRACELLULAR IMAGING AND PROTEIN CARRIER

Номер: US20130210047A1

Provided herein are magnetic silica fluorescent nanoparticles and fluorescent silica nanoparticles comprising an aggregation induced emission luminogen and magnetite nanoparticles and use of the same as a fluorescent bioprobe for intracellular imaging and a protein carrier. Also provided are processes for preparing and fabricating the same. 3. The fluorescent bioprobe of claim 1 , wherein the magnetic fluorescent silica nanoparticles and the fluorescent silica nanoparticles are also protein carriers.4. The fluorescent bioprobe of claim 1 , wherein the magnetic fluorescent silica nanoparticles and fluorescent silica nanoparticles exhibit aggregation-induced emission.5. The fluorescent bioprobe of claim 1 , wherein the magnetic fluorescent silica nanoparticles exhibit superparamagnetism.6. The fluorescent bioprobe of claim 1 , wherein the magnetic fluorescent silica nanoparticles exhibit high magnetization with negligible remanence and coercivity.7. The fluorescent bioprobe of claim 1 , wherein the magnetic fluorescent silica nanoparticles and the fluorescent silica nanoparticles emit light; and wherein the light emission increases with increased luminogen loading.8. The fluorescent bioprobe of claim 1 , wherein the aggregation induced emission luminogen is in solid form.9. The fluorescent bioprobe of claim 1 , wherein the magnetic fluorescent silica nanoparticles comprise magnetic cores covered by a silica shell.10. The fluorescent bioprobe of claim 1 , wherein the fluorescent silica nanoparticles comprise fluorescent cores covered by a silica shell.11. The fluorescent bioprobe of claim 1 , wherein the magnetic fluorescent silica nanoparticles and the fluorescent silica nanoparticles are spherical with substantially uniform sizes and narrow particle distributions.12. The fluorescent bioprobe of claim 1 , wherein the magnetic fluorescent silica nanoparticles and the fluorescent silica nanoparticles possess high surface charges and good colloidal stabilities.13. The ...

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29-08-2013 дата публикации

Frequency selective electromagnetic detector

Номер: US20130221210A1
Автор: Jeffrey H. Hunt
Принадлежит: Boeing Co

An apparatus, system, and method are disclosed for a frequency selective electromagnetic detector. In particular, the frequency selective electromagnetic detector includes a nanowire array constructed from a plurality of nanowires of different compositions. At least one nanoparticle-sized diameter thermoelectric junction is formed between the nanowires of different compositions. When a nanoparticle-sized diameter thermoelectric junction senses a photon, the nanoparticle-sized diameter thermoelectric junction emits an electrical pulse voltage that is proportional to an energy level of the sensed photon. In one or more embodiments, the frequency selective electromagnetic detector is a frequency selective optical detector that is used to sense photons having optical frequencies. In at least one embodiment, at least one of the nanowires in the nanowire array is manufactured from a compound material including Bismuth (Bi) and Tellurium (Te).

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29-08-2013 дата публикации

Atomic force microscope probe

Номер: US20130227749A1
Автор: Shou-Shan Fan, Yang Wei

An atomic force microscope probe includes a carbon nanotube micro-tip structure. The carbon nanotube micro-tip structure includes an insulating substrate and a patterned carbon nanotube film structure. The insulating substrate includes a surface. The surface includes an edge. The patterned carbon nanotube film structure is partially arranged on the surface of the insulating substrate. The patterned carbon nanotube film structure includes two strip-shaped arms joined together to form a tip portion protruding and suspending from the edge of the surface of the insulating substrate. The two strip-shaped arms include a number of carbon nanotubes parallel to the surface of the insulating substrate.

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05-09-2013 дата публикации

Imaging Probe Including Nanoparticle

Номер: US20130230464A1
Принадлежит:

An imaging probe can include a photoluminescent carbon nanostructure configured to emit a wavelength of light detectable through living tissue, and a targeting moiety including a first binding partner configured to interact with a second binding partner. 1. An imaging probe , comprising:a photoluminescent nanostructure configured to emit a wavelength of light detectable through living tissue; anda targeting moiety including a first binding partner configured to interact with a second binding partner.2. The imaging probe of claim 1 , wherein the second binding partner includes a tissue-type specific or cell-type specific molecule.3. The imaging probe of claim 1 , wherein the second binding partner includes a protein.4. The imaging probe of claim 1 , wherein the first binding partner includes a protein.5. The imaging probe of claim 1 , wherein the first binding partner includes at least a portion of an antibody.6. The imaging probe of claim 1 , wherein the first binding partner includes at least a portion of a ligand and the second binding partner includes a receptor.7. The imaging probe of claim 1 , wherein the targeting moiety includes at least one viral protein.8. The imaging probe of claim 7 , wherein the at least one viral is a M13 bacteriophage protein.9. The imaging probe of claim 7 , wherein the at least one viral protein is a capsid protein.10. The imaging probe of claim 1 , wherein the first binding partner and the at least one viral protein comprise a chimeric protein.11. The imaging probe of claim 1 , wherein the photoluminescent nanostructure is a carbon nanostructure.12. The imaging probe of claim 1 , wherein the first binding partner configured to interact with the second binding partner in vivo.13. The imaging probe of claim 1 , wherein the first binding partner configured to interact with the second binding partner ex vivo.14Escherichia coli.. The imaging probe of claim 1 , wherein the targeting moiety includes15Escherichia coli. The imaging probe of ...

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12-09-2013 дата публикации

DIRECT DETECTION OF UNAMPLIFIED HEPATITIS C VIRUS RNA USING UNMODIFIED GOLD NANOPARTICLES

Номер: US20130236880A1
Принадлежит: American University of Cairo

A gold nanoparticle-based colorimetric assay kit for hepatitis C virus RNA that detects unamplified HCV RNA in clinical specimens using unmodified AuNPs and oligotargeter polynucleotides that bind to HCV RNA. A method for detecting hepatitis C virus comprising contacting a sample suspected of containing hepatitis C virus with a polynucleotide that binds to hepatitis C virus RNA and with gold nanoparticles, detecting the aggregation of nanoparticles, and detecting hepatitis C virus in the sample when the nanoparticles aggregate (solution color becomes blue) in comparison with a control or a negative sample not containing the virus when nanoparticles do not aggregate (solution color remains red). 1. A method for detecting hepatitis C virus comprisingcontacting a sample suspected of containing hepatitis C virus with an oligotargeter that binds to hepatitis C virus RNA and with gold nanoparticles,detecting the aggregation of nanoparticles, anddetecting hepatitis C virus in the sample when the nanoparticles aggregate (solution becomes blue) in comparison with a control or a negative sample not containing the virus where the nanoparticles do not aggregate (solution remains red).2. The method of claim 1 , wherein the sample is blood or plasma.3. The method of claim 1 , wherein the sample is serum claim 1 , optionally containing EDTA.4. The method of claim 1 , wherein the sample is saliva.5. The method of claim 1 , wherein the sample is urine.6. The method of claim 1 , wherein the gold nanoparticles are spherical and have an average diameter of 12 to 20 nm.7. The method of claim 1 , wherein the gold nanoparticles are spherical and have an average diameter of 15-18 nm.8. The method of claim 1 , wherein the oligotargeter that binds to hepatitis C RNA comprises a portion of a 5′ untranslated region of hepatitis C genomic RNA.9. The method of claim 1 , wherein the oligotargeter that binds to hepatitis C RNA comprises a portion of hepatitis C genomic RNA other than the 5′ ...

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19-09-2013 дата публикации

ELECTRON MULTIPLIER DEVICE HAVING A NANODIAMOND LAYER

Номер: US20130240907A1
Принадлежит: PHOTONIS FRANCE

An electron multiplier for a system for detecting electromagnetic radiation or an ion flow is disclosed. The multiplier includes at least one active structure intended to receive a flow of incident electrons, and to emit in response a flow of electrons called secondary electrons. The active structure includes a substrate on which is positioned a thin nanodiamond layer formed from diamond particles the average size of which is less than or equal to about 100 nm. 1. A reflection-mode electron multiplier device to detect electromagnetic radiation or ion flows , the device comprising:at least one active structure configured to receive a flow of incident electrons and to emit in response a flow of secondary electrons, where the active structure comprises a substrate and a thin nanodiamond layer on the substrate, the nanodiamond layer being formed of diamond particles, the average size of the particles is less than about 100 nm,wherein the active structure is a microchannel wafer in which each of a plurality of microchannels traverses the substrate from an input aperture for the flow of incident electrons to an output aperture for the flow of the secondary electrons, where the nanodiamond layer extends over the inner surface of each of the microchannels from the corresponding input aperture.2. An electron multiplier device according to claim 1 , wherein the nanodiamond layer extends over a length of a microchannel of between one and thirty times the average diameter of the microchannels.3. An electron multiplier device according to claim 1 , wherein the nanodiamond layer extends over an inner surface of each of the microchannels for as far as a distance claim 1 , relative to the corresponding output aperture claim 1 , of between one and ten times the average diameter of the microchannels.4. An electron multiplier device according to claim 1 , wherein the nanodiamond layer extends over the entire length of an inner surface of each of the microchannels for as far as the ...

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24-10-2013 дата публикации

DETECTOR OF SINGLE MICROWAVE PHOTONS PROPAGATING IN A GUIDE

Номер: US20130281302A1
Принадлежит: Aalto-Korkeakoulusäätiö

The present invention introduces a detector that is able to detect single microwave photons propagating in a waveguide. The waveguide of the invention is lowered to a temperature where it becomes superconductive. Disposed between a middle wire and a ground plane of the waveguide is a very small piece of a desired normal metal, whereby so-called SN contacts are formed between these materials. A separate reflection measurement circuit is coupled to the normal metal piece. When the impedance of the waveguide is matched to the impedance of the normal metal piece as well as possible, a photon propagating in the waveguide is most likely absorbed in the normal metal. The absorption slightly raises the temperature of the piece, which further changes the impedance observed in a so-called SIN junction between the reflection measurement circuit and the piece. The changed amplitude and phase are detectable at the outlet obtained from a mixer of the reflection measurement circuit, whereby a single absorbed photon can be detected. In principle, the present method and device enable quantum calculation in view of future applications. 110. A method for detecting single microwave photons in a metallic waveguide () , the method comprising the step:{'b': '10', 'creating at least one microwave photon in the waveguide () disposed in a superconductive state;'} [{'b': 10', '11, 'directing at least one microwave photon from the waveguide () to a resistive element () in a manner as free of losses as possible; and'}, {'b': 18', '11', '18', '11, 'measuring, by a reflection measurement circuit (), a change of impedance in a junction between the resistive element () and the reflection measurement circuit () due to heating of the resistive element ().'}], 'characterized in that the method further comprises the steps2. The method according to claim 1 , characterized in that the method further comprises the step:{'b': 10', '11', '10', '10', '10, 'i': b', 'b', 'a, 'matching the impedance of the ...

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24-10-2013 дата публикации

Enhancing surface plasmon resonance imaging signal

Номер: US20130281315A1

Described is a biointerface using near-infrared quantum dots for surface plasmon resonance imaging biosensors.

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24-10-2013 дата публикации

Diamond electrode nanogap transducers

Номер: US20130281325A1
Принадлежит: Intel Corp

Embodiments of the invention provide transducers capable of transducing redox active chemical signals into electrical signals. Transducers comprise two electrodes separated by a nanogap. At least one electrode is comprised of conducting diamond. Methods of fabricating nanogap transducers and arrays of nanogap transducers are provided. Arrays of individually addressable nanogap transducers can be disposed on integrated circuit chips and operably coupled to the integrated circuit chip.

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31-10-2013 дата публикации

Microscale Metallic CNT Templated Devices and Related Methods

Номер: US20130285160A1
Принадлежит: BRIGHAM YOUNG UNIVERSITY

A microscale device comprises a patterned forest of vertically grown and aligned carbon nanotubes defining a carbon nanotube forest with the nanotubes having a height defining a thickness of the forest, the patterned forest defining a patterned frame that defines one or more components of a microscale device. A conformal coating of substantially uniform thickness at least partially coats the nanotubes, defining coated nanotubes and connecting adjacent nanotubes together, without substantially filling interstices between individual coated nanotubes. A metallic interstitial material infiltrates the carbon nanotube forest and at least partially fills interstices between individual coated nanotubes. 1. A microscale device , comprising:a patterned forest of vertically grown and aligned carbon nanotubes defining a carbon nanotube forest with the nanotubes having a height defining a thickness of the forest, the patterned forest defining a patterned frame that defines one or more components of a microscale device;a conformal coating of substantially uniform thickness at least partially coating the nanotubes, defining coated nanotubes and connecting adjacent nanotubes together, without substantially filling interstices between individual coated nanotubes; anda metallic interstitial material infiltrating the carbon nanotube forest and at least partially filling interstices between individual coated nanotubes.2. The device of claim 1 , wherein at least one component of the patterned frame is fixed and at least one component of the patterned frame is moveable relative to the fixed component.3. The device of claim 1 , wherein the metallic interstitial material is applied by an electroplating process.4. The device of claim 1 , wherein conformal coating comprises a carbon material.5. The device of claim 1 , wherein the thickness of the carbon nanotube forest is between 3 μm (microns) and 9 mm.6. The device of claim 1 , wherein the microscale device comprises a MEMS device.7. The ...

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31-10-2013 дата публикации

SEMICONDUCTOR DEVICES HAVING NANOCHANNELS CONFINED BY NANOMETER-SPACED ELECTRODES

Номер: US20130288417A1
Принадлежит:

Semiconductor devices having integrated nanochannels confined by nanometer spaced electrodes, and VLSI (very large scale integration) planar fabrication methods for making the devices. A semiconductor device includes a bulk substrate and a first metal layer formed on the bulk substrate, wherein the first metal layer comprises a first electrode. A nanochannel is formed over the first metal layer, and extends in a longitudinal direction in parallel with a plane of the bulk substrate. A second metal layer is formed over the nanochannel, wherein the second metal layer comprises a second electrode. A top wall of the nanochannel is defined at least in part by a surface of the second electrode and a bottom wall of the nanochannel is defined by a surface of the first electrode. 1. A method of forming a semiconductor device , comprising:depositing a first metal layer on a bulk substrate, the first metal layer comprising a first electrode;depositing a first dielectric layer on the first metal layer, the first dielectric layer having a thickness h;depositing a second dielectric layer on the first dielectric layer;forming a second metal layer on the second dielectric layer, the second metal layer comprising a second electrode having a width w, which extends through the second dielectric layer down to the first dielectric layer;etching the first dielectric layer selective to the first metal layer, the second metal layer and the second dielectric layer to faun an undercut structure at a lateral depth d into a side surface of the first dielectric layer; andanisotropically depositing a third dielectric layer to enclose the undercut structure in the first dielectric layer to form a nanochannel that longitudinally extends in a direction parallel to a plane of the bulk substrate,wherein a top wall of the nanochannel is defined at least in part by a surface of the second electrode and a bottom surface of the second dielectric layer,wherein a bottom wall of the nanochannel is defined by ...

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07-11-2013 дата публикации

BIO-CHIP FOR SECONDARY ION MASS SPECTROSCOPY AND METHOD OF FABRICATING THE SAME

Номер: US20130292561A1

There are provided a bio-chip for secondary ion mass spectrometry and a method of fabricating the same, the bio-chip, which is a bio-chip for analyzing a biochemical material using the secondary ion mass spectrometry, including: a substrate; and core-shell particles positioned above substrate, wherein the core-shell particles each include a metal nanoparticle as a core and a metal shell surrounding the metal nanoparticle.

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07-11-2013 дата публикации

METHOD AND APPARATUS FOR PROVIDING A MULTIFUNCTION SENSOR USING MESH NANOTUBE MATERIAL

Номер: US20130293429A1

A method and apparatus for providing multiple functions using nanotube threads comprising: a first nanotube thread and a second nanotube thread, the first nanotube thread and the second nanotube thread arranged to form a mesh, wherein the first nanotube thread further comprises a measurable invariant property and the second nanotube thread comprises a measurable variant property. 1. An apparatus for providing multiple functions using nanotube threads comprising:a first nanotube thread and a second nanotube thread, the first nanotube thread and the second nanotube thread arranged to form a mesh;wherein the first nanotube thread further comprises a measurable invariant property and the second nanotube thread comprises a measurable variant property.2. The apparatus of claim 1 , wherein the nanotubes are carbon nanotubes and the first nanotube thread and the second nanotube thread claim 1 , alternately orthogonally cross each other to form the mesh.3. The apparatus of claim 1 , wherein the first nanotube thread is a conductive material and the second nanotube thread is a semiconductive material claim 1 , the semiconductive material having a characteristic that changes when the semiconductive material is exposed to a particular gas.4. The apparatus of claim 3 , wherein the first nanotube thread comprises at least one of a conductive multiwall nanotube thread or a conductive single wall nanotube thread claim 3 , and the second nanotube thread comprises at least one of a semiconductive multiwall nanotube thread with defects added or a single wall nanotube thread with defects added.5. The apparatus of claim 1 , further comprising the mesh on a substrate mounted on a ground plane claim 1 , a microstrip feedline on the ground plane claim 1 , and an aperture in the substrate and ground plane to couple the mesh to the microstrip feedline.6. The apparatus of claim 5 , wherein the feedline is coupled to a transceiver and a gas detector.7. The apparatus of wherein intersections of ...

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07-11-2013 дата публикации

OPTICAL PHANTOMS FOR USE WITH OCULAR SURFACE INTERFEROMETRY (OSI) DEVICES AND SYSTEMS CONFIGURED TO MEASURE TEAR FILM LAYER THICKNESS(ES), AND RELATED USE FOR CALIBRATION

Номер: US20130293842A1
Принадлежит: TearScience, Inc.

Embodiments of the detailed description include optical phantoms for use with ocular surface interferometery (OSI) devices and systems configured to measure tear film layer thickness(es), and related use for calibration. The ocular surface interferometry (OSI) devices, systems, and methods can be used for imaging an ocular tear film and/or measuring a tear film layer thickness (TFLT) in a patient's ocular tear film. The OSI devices, systems, and methods can be used to measure the thickness of the lipid layer component (LLT) and/or the aqueous layer component (ALT) of the ocular tear film. “TFLT” as used herein includes LLT, ALT, or both LLT and ALT. “Measuring TFLT” as used herein includes measuring LLT, ALT, or both LLT and ALT. Imaging the ocular tear film and measuring TFLT can be used in the diagnosis of a patient's tear film, including but not limited to lipid layer and aqueous layer deficiencies. 1. An optical phantom having specularly reflective characteristics of an ocular tear film , comprising:a substrate; andat least one material layer disposed onto the substrate;wherein the at least one material layer provides a refractive index ratio between the at least one material layer and the substrate to mimic or substantially mimic a refractive index ratio between a lipid layer and an aqueous layer of an ocular tear film.2. The optical phantom of claim 1 , wherein the substrate comprises fused silica.3. The optical phantom of claim 2 , wherein an index of refraction of the fused silica is about 1.46.4. The optical phantom of claim 1 , wherein the substrate comprises crown glass.5. The optical phantom of claim 4 , wherein an index of refraction of the crown glass is approximately 1.517.6. The optical phantom of claim 1 , wherein the at least one material layer comprises magnesium oxide (MgO).7. The optical phantom of claim 1 , wherein the at least one material layer has an index of refraction of approximately 1.68.8. The optical phantom of claim 1 , wherein at ...

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14-11-2013 дата публикации

TOUCH PANEL AND METHOD FOR MANUFACTURING ELECTRODE MEMBER

Номер: US20130299220A1
Принадлежит: LG INNOTEK CO., LTD.

Provided is a touch panel. The touch panel includes a substrate and an electrode member disposed on the substrate. The electrode member includes a base material for electrode having first and second surfaces opposite to each other, a first electrode disposed on the first surface, and a second electrode disposed on the second surface. 1. A touch panel comprising:a substrate; andan electrode member disposed on the substrate, wherein the electrode member comprises:a base material for electrode having first and second surfaces opposite to each other;a first electrode disposed on the first surface; anda second electrode disposed on the second surface.2. The touch panel according to claim 1 , wherein the first electrode is disposed in a first direction claim 1 , and the second electrode is disposed in a second direction crossing the first direction.3. The touch panel according to claim 1 , wherein the first and second electrodes are formed of at least one selected from the group consisting of indium tin oxide claim 1 , indium zinc oxide claim 1 , carbon nano tube (CNT) claim 1 , conductive polymer claim 1 , and Ag nano wire.4. The touch panel according to claim 1 , wherein the base material for electrode is formed of at least one of poly (ethylene terephthalate (PET)) film and glass.5. The touch panel according to claim 1 , further comprising an optically clear adhesive (OCA) between the substrate and the electrode member.6. A method for manufacturing an electrode member claim 1 , the method comprising:preparing a base material for electrode; andforming a electrode on first and second surfaces opposite to each other.7. The method according to claim 6 , wherein the forming of the electrode comprises an exposure process.8. The method according to claim 7 , wherein the forming of the electrode comprises exposing the first and second surfaces of the base material for electrode at the same time to form the electrode.9. (canceled)10. (canceled)11. The method according to claim ...

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