Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 2304. Отображено 100.
20-07-2012 дата публикации

УСТАНОВКА ДЛЯ ОМЫЛЕНИЯ СЛОЖНЫХ ЭФИРОВ В ПРОИЗВОДСТВЕ КАПРОЛАКТАМА И УСТАНОВКА ДЛЯ УТИЛИЗАЦИИ НАТРИЕВЫХ СОЛЕЙ ОРГАНИЧЕСКИХ КИСЛОТ

Номер: RU0000118217U1
Автор: Дульченко Григорий Иванович, Пугач Фёдор Владимирович, Савош Эдуард Казимирович, Сокол Борис Александрович, Сурба Анатолий Константинович, Таракановский Игорь Викторович
Принадлежит: Открытое акционерное общество "Щекиноазот"

1. Установка для омыления сложных эфиров в производстве капролактама, включающая расположенные в технологической последовательности узел подачи реакционной жидкости, аппараты дистилляции кислого циклогексана, реактор омыления и нейтрализации, разделительный сосуд с выходом на агрегаты термического разложения смеси побочных продуктов и аппараты дистилляции нейтрального циклогексана, связанные с колонной осушки кетоно-спиртовой смеси и ректификационными колоннами, отличающаяся тем, что между аппаратами дистилляции кислого циклогексана и реактором омыления и нейтрализации установлен смеситель кубовой жидкости с раствором нейтрализующего агента, между аппаратами дистилляции нейтрального циклогексана и колонной осушки кетоно-спиртовой смеси расположен дополнительный реактор омыления с узлом подачи водного раствора щелочи и узлом разделения смеси на водный и органический слой, связанный с реактором омыления и нейтрализации и экстрактором отмывки остатков солей из органического слоя, который связан с аппаратом осушки и реактором омыления и нейтрализации, а агрегат термического разложения смеси побочных продуктов снабжен узлом приготовления раствора кальцинированной соды и ее подачи в смеситель кубовой жидкости с раствором нейтрализующего агента. 2. Установка по п.1, отличающаяся тем, что узел приготовления выполнен в виде переливной емкости, связанной с усреднителем-накопителем. 3. Установка для утилизации натриевых солей органических кислот в производстве капролактама, включающая реактор огневого разложения с трубопроводами подачи воздуха, природного газа, натриевых солей органических кислот, скруббер очистки дымовых газов с водяным оросителем, дымосос и дымовую трубу, стол-кристаллизатор вытекающего из реактора расплава соды и узел сбора плава соды, отличающаяся тем, что она снабжена узлом растворения плава соды, состоящим из двух секций с переливной перегородкой между ними, одна из секций соединена с узлом подачи химически очищенной воды и снабжена паровым барботером, а ...

Подробнее
Номер записи: 1
09-02-2012 дата публикации

Organophosphorus compounds, catalytic systems comprising said compounds and method of hydrocyanation or of hydroformylation using said catalytic systems

Номер: US20120035377A1
Автор: Igor Mikhel, Paul Pringle, Sergio Mastroianni
Принадлежит: Rhodia Operations SAS

Organophosphorus compounds, catalytic systems comprising a metallic element forming a complex with the organophosphorus compounds and methods of hydrocyanation and of hydroformylation employed in the presence of the catalytic systems are described.

Подробнее
Номер записи: 2
05-07-2012 дата публикации

Zinc cluster

Номер: US20120172601A1
Автор: Hideki Nara, Takahiro Fujiwara, Yoshimasa Matsushima
Принадлежит: Takasago International Corp

Disclosed is a novel zinc cluster compound represented by general formula (1): Zn 4 O (OCOR) 6 (RCOOH) n , wherein R represents an alkyl group which has 1 to 4 carbon atoms and may be substituted with a halogen atom, and n represents 0.1 to 1, and also disclosed are a method for producing the compound and a reaction using the compound.

Подробнее
Номер записи: 3
20-12-2012 дата публикации

Process and intermediate compounds useful in the preparation of statins

Номер: US20120323011A1
Автор: David John Moody, Jonathan William Wiffen
Принадлежит: Redx Pharna PLC

There is provides a process for the preparation of a compound of formula (7): wherein R is an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; provides that R is not a compound of Formula (a): wherein R a represents an alkyl group, such as a C 1-16 alkyl group, and preferably an isopropyl group; R b represents an aryl group, preferably a 4-fluorophenyl group; R c represents hydrogen, a protecting group or an alkyl group, such as a C 1-16 alkyl group, and preferably a methyl group; and Rd represents hydrogen, a protecting group or a SO 2 R e group where R e is an alkyl group, such as a C 1-16 alkyl group, and preferably a methyl group.

Подробнее
Номер записи: 4
03-01-2013 дата публикации

Process for the conversion of aromatic nitro compound into amines

Номер: US20130006018A1
Автор: Christopher John Mitchell, Douglas Hyndman Stewart
Принадлежит: Huntsman International LLC

A process for hydrogenating an aromatic nitro compound according to the invention comprises providing a hydrogen gas stream and a liquid aromatic nitro compound stream; providing a fixed bed catalytic reactor having an inflow side and an outflow side; feeding to the inflow side, the hydrogen gas stream and the liquid aromatic nitro compound stream; converting the hydrogen gas and the aromatic nitro compound into an aromatic amine, thereby providing a reactor effluent comprising the aromatic amine and water; evacuating the reactor effluent from the reactor at the outflow side of the reactor; wherein an inert solvent or water is fed to the inflow side of the reactor at a molar ratio of moles inert solvent or water to moles hydrogen is more than 1.

Подробнее
Номер записи: 5
14-03-2013 дата публикации

PROCESS FOR HYDROCHLORINATION OF MULTIHYDROXYLATED ALIPHATIC HYDROCARBONS

Номер: US20130066091A1
Автор: Arrowood Tina L., Briggs John R., JR. William J., Kruper
Принадлежит: Dow Global Technologies LLC

A process for producing a chlorohydrin, an ester of a chlorohydrin, or a mixture thereof including the steps of contacting, in a hydrochlorination reactor, a multihydroxylated aliphatic hydrocarbon, an ester of a multihydroxylated aliphatic hydrocarbon, or a mixture thereof with a source of a hydrogen chloride, in the presence of a hydrophobic or extractable carboxylic acid catalyst is provided. 1. A process for producing a chlorohydrin , an ester of a chlorohydrin , or a mixture thereof comprising:contacting, in a hydrochlorination reactor, a multihydroxylated aliphatic hydrocarbon, a multihydroxylated aliphatic hydrocarbon ester, or a mixture thereof with a source of hydrogen chloride, in the presence of a hydrophobic carboxylic acid catalyst to produce a first product stream comprising chlorohydrins, hydrophobic chlorohydrin esters, or a mixture thereof;phase separating the first product stream into a hydrophobic stream and a non-hydrophobic stream, wherein the non-hydrophobic stream comprises water and hydrogen chloride and the hydrophobic stream comprises the hydrophobic chlorohydrin esters, and the hydrophobic carboxylic acid catalyst; andrecovering the hydrophobic stream by decantation.2. The process of further comprising:adding strong base to the hydrophobic stream to form a second product stream comprising epoxides, water, and the hydrophobic carboxylic acid catalyst and salts thereof; andseparating the second product stream into a first epoxide stream and a first carboxylic acid/salt stream comprising the hydrophobic carboxylic acid and salts thereof.3. The process of further comprising:adding a mineral acid to the first carboxylic acid/salt stream to form a first recovery stream comprising hydrophobic carboxylic acid, and a first discard stream comprising water and a salt;separating the first recovery stream into a hydrophobic carboxylic acid catalyst component and an aqueous salt component; andrecycling the hydrophobic carboxylic acid catalyst component ...

Подробнее
Номер записи: 6
04-04-2013 дата публикации

CARBOXYLATION CATALYSTS

Номер: US20130085276A1
Автор: Cazin Catherine, NOLAN Steven P.
Принадлежит:

The use of a complex of the form Z—M—OR in the carboxylation of a substrate is described. The group Z is a two-electron donor ligand, M is a metal and OR is selected from the group consisting of OH, alkoxy and aryloxy. The substrate may be carboxylated at a C—H or N—H bond. The metal M may be copper, silver or gold. The two-electron donor ligand may be a phosphine, a carbene or a phosphite ligand. Also described are methods of manufacture of the complexes and methods for preparing isotopically labelled caboxylic acids and carboxylic acid derivatives. 134-. (canceled)25. A method of carboxylation of a substrate , the method comprising;{'sub': '2', 'contacting a complex of the form Z—M—OR ,wherein the group Z is a two-electron donor ligand, M is a metal, and OR is selected from the group consisting of OH, alkoxy and aryloxy; with a substrate and a source of CO.'}26. The method according to claim 25 , wherein the metal M is selected from the group consisting of copper claim 25 , silver and gold.27. The method according to claim 25 , wherein the carboxylation is carried out in the presence of a base.28. The method according to claim 27 , wherein the base is an alkali metal hydroxide or alkoxide.29. The method according to claim 25 , wherein the two-electron donor ligand Z is selected from the group consisting of phosphines claim 25 , carbenes claim 25 , or phosphites.30. The method according to claim 29 , wherein the two-electron donor ligand Z is a nitrogen containing heterocyclic carbene ligand.33. The method according to claim 26 , wherein the complex is selected from the group consisting of: [M(OH)(IMes)] claim 26 , [M(OH)(SIMes)] claim 26 , [M(OH)(IPr)] claim 26 , [M(OH)(ItBu)] claim 26 , and [M(OH)(SIPr)] claim 26 , where M is Au claim 26 , Ag or Cu.34. The method according to claim 25 , wherein the substrate is carboxylated at a C—H or N—H bond.35. The method according to claim 25 , wherein the substrate is a substituted or unsubstituted aromatic compound.36. The ...

Подробнее
Номер записи: 7
25-04-2013 дата публикации

Method for the preparation of cis-1,2-diols in the kilogram scale

Номер: US20130102640A1
Автор: Andreas Werner, Georg Stoehr, Werner Mederski
Принадлежит: Merck Patent GmBH

The present invention relates to the scale up of the preparation of cis-1,2-diols of formula I from the gram to the kilogram scale.

Подробнее
Номер записи: 8
16-05-2013 дата публикации

Synthesis of High Caloric Fuels and Chemicals

Номер: US20130118063A1
Автор: Jan Zygmunt, John Henri, Mark Bergren, Robert Zubrin
Принадлежит: PIONEER ENERGY INC

In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.

Подробнее
Номер записи: 9
16-05-2013 дата публикации

OLEFIN OLIGOMER COMPOSITION

Номер: US20130123551A1
Автор: DE KRAKER Abraham Robert
Принадлежит: SHELL OIL COMPANY

Processes for the production of an alcohol, esters and aliphatic hydrocarbons are provided. In one embodiment, a process for the production of an alcohol comprises: oligomerizing an olefin or a mixture of olefins having the structural formula CH—CH═CH, wherein n is an integer from 4 to 22, in the presence of an oligomerization catalyst, so as to form a vinylidene containing olefin oligomer; hydroformylating the vinylidene containing olefin oligomer in the presence of a hydroformylation catalyst so as to form a hydroformylated olefin oligomer; and dimerizing the hydroformylated olefin oligomer by means of a Guerbet reaction so as to form the alcohol. 2. The process according to further comprising purifying the hydroformylated olefin oligomer by distillation prior to step c).3. The process according to further comprising recovering the alcohol.5. The process according to wherein R-Reach contain from 1 to 17 carbon atoms (n=4 to 16).6. The process according to wherein R-Reach contain from 3 to 15 carbon atoms (n=6 to 14).7. The process according to wherein R-Reach contain from 3 to 13 carbon atoms (n=6 to 12).8. The process according to wherein R-Reach contain from 5 to 13 carbon atoms (n=8 to 12).9. The process according to wherein R-Reach contain from 5 to 11 carbon atoms (n=8 to 10).10. The process according to wherein R-Reach contain from 7 to 13 carbon atoms (n=10 to 12).11. The process according to further comprising recovering the saturated aliphatic hydrocarbons.12. The process according to further comprising reacting the alcohol in step c) with an organic adic so as to form an ester.13. The process according to wherein the oligomerization in step a) is a dimerization step that produces an olefin dimer.14. The process according to wherein the oligomerization in step a) is a trimerization step that produces an olefin trimer.15. The process according to wherein the oligomerization catalyst is a metallocene compound.16. The process according to wherein the ...

Подробнее
Номер записи: 10
13-06-2013 дата публикации

ALKOXYLATION METHOD OF FATTY ACID ALKYL ESTERS

Номер: US20130150601A1
Автор: Kolano Christoph, Möhle Lothar, Richner Rudolf
Принадлежит: KOLB DISTRIBUTION LTD.

The present invention is directed towards a method of preparing alkoxylated fatty acid alkyl estersin a one-pot alkoxylation reaction in the presence of a catalyst which is an alkaline earth metal oxide/mineral acid combination, preferably a barium oxide/sulfuric acid combination, or a Lewis acid, preferably Sn Cl, comprising the steps of: a) providing a fatty acid alkyl ester, b) adding a catalyst to said fatty acid alkyl ester to obtain a first mixture, wherein said catalyst is an alkaline earth metal oxide/mineral acid combination or a Lewis acid, c) adding one or more alkylene oxides to said first mixture to obtain a second mixture and (d) isolating the alkoxylated fatty acid alkyl ester. 1. A method for preparing an alkoxylated fatty acid alkyl ester in a one-pot reaction comprising the steps of:(a) providing a fatty acid alkyl ester,(b) adding a catalyst to said fatty acid alkyl ester to obtain a first mixture, wherein said catalyst is an alkaline earth metal oxide/mineral acid combination or a Lewis acid,(c) adding one or more alkylene oxides to said first mixture to obtain a second mixture and(d) isolating the alkoxylated fatty acid alkyl ester.3. A method according to claim 1 , wherein the alkaline earth metal oxide and the mineral acid are added simultaneously or sequentially.4. A method according to claim 3 , wherein the alkaline earth metal oxide is an oxide of Group II elements claim 3 , preferably barium oxide.5. A method according to claim 4 , wherein the alkaline earth metal oxide is at a concentration of less than 5 wt % preferably 0.5 to 1.5 wt %6. A method according to claim 1 , wherein the mineral acid is selected from sulfuric acid claim 1 , hydrochloric acid claim 1 , perchloric acid claim 1 , nitric acid claim 1 , phosphoric acid claim 1 , preferably sulfuric acid.7. A method according to claim 6 , wherein the mineral acid is at a concentration of less than 5 wt % preferably less than 2 wt %8. A method according to claim 1 , wherein the ratio ...

Подробнее
Номер записи: 11
20-06-2013 дата публикации

Process for the Preparation of Oxidized Phospholipids

Номер: US20130158283A1
Автор: Eti Kovalevski-Ishai, Gideon Halperin
Принадлежит: Vascular Biogenics Ltd

Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.

Подробнее
Номер записи: 12
27-06-2013 дата публикации

METHOD FOR THE SYNTHESIS OF AN AMINO ACETAL

Номер: US20130165682A1
Автор: Loh Teck Peng, Tian Jiesheng
Принадлежит: NANYANG TECHNOLOGICAL UNIVERSITY

The present invention relates to a method for the synthesis of an α amino acetal, comprising (i) oxidizing a tertiary amine in the presence of a copper catalyst, at least one oxidant and a solvent, or (ii) reacting a secondary amine and an aliphatic aldehyde in the presence of a copper catalyst, at least one oxidant and a solvent. 1. A method for the synthesis of an α-amino acetal , comprising(i) oxidizing a tertiary amine in the presence of a copper catalyst, at least one oxidant and a solvent, or(ii) reacting a secondary amine and an aliphatic aldehyde in the presence of a copper catalyst, at least one oxidant and a solvent.5. The method of claim 1 , wherein the reaction is carried out in the presence of a nitrogen donor ligand.6. The method of claim 5 , wherein the nitrogen donor ligand is N claim 5 ,N claim 5 ,N′ claim 5 ,N′-tetramethylethylenediamine (TMEDA).7. The method of claim 6 , wherein the molar ratio of copper catalyst:TMEDA is between about 1:1 and about 1:5.8. The method of claim 7 , wherein the molar ratio of copper catalyst:TMEDA is about 1:2.9. The method of claim 1 , wherein the copper catalyst is copper (II) halide or copper (I) halide.10. The method of claim 9 , wherein the halide is iodide claim 9 , bromide or chloride.11. The method of claim 10 , wherein the copper catalyst is selected from the group consisting of CuBr claim 10 , CuI claim 10 , CuI claim 10 , and CuBr.12. The method of claim 2 , wherein the copper catalyst is CuBror CuI.13. The method of claim 3 , wherein the copper catalyst is CuI claim 3 , CuBr or CuBr.14. The method of claim 1 , wherein the one or more alcohols are methanol or ethanol.1516.-. (canceled)17. The method of claim 1 , wherein the solvent is an organic solvent selected from the group consisting of acetonitrile (MeCN) claim 1 , methanol (MeOH) claim 1 , 1 claim 1 ,2-dichloroethane (DCE) claim 1 , tetrahydrofuran (THF) claim 1 , dimethyl sulfoxide (DMSO) claim 1 , and mixtures thereof.18. The method of claim 17 , ...

Подробнее
Номер записи: 13
04-07-2013 дата публикации

Method for producing alcohol and/or amine from amide compound

Номер: US20130172619A1
Автор: Osamu Ogata, Takaji Matsumoto, Wataru Kuriyama
Принадлежит: Takasago International Corp

Disclosed herein is a method for producing an alcohol and an amine from an amide under an atmosphere of hydrogen with the use of, as a catalyst, a ruthenium complex that is easily prepared, easy to handle, and relatively cheaply obtained. Specifically, the method is a method for producing an alcohol and/or an amine from an amide compound under an atmosphere of hydrogen with the use of as a catalyst, a ruthenium carbonyl complex represented by the following general formula (1): RuXY(CO)(L) (1) wherein X and Y may be the same or different from each other and each represents an anionic ligand and L represents a tridentate aminodiphosphine ligand containing two phosphino groups and a —NH— group.

Подробнее
Номер записи: 14
25-07-2013 дата публикации

Process for the Preparation of Oxidized Phospholipids

Номер: US20130190523A1
Автор: Halperin Gideon, Kovalevski-Ishai Eti
Принадлежит: Vascular Biogenics Ltd.

Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates firmed thereby. 1. A method of preparing a compound having a glycerolic backbone and at least one oxidized moiety-containing residue attached to the glycerolic backbone via an ether bond , the method comprising:providing a first compound having a glycerolic backbone and at least one free hydroxyl group;providing a second compound having at least one unsaturated bond and at least one reactive group capable of forming an ether bond with said free hydroxyl group;reacting said first compound and said second compound to thereby obtain a third compound, said third compound having a glycerolic backbone and an unsaturated bond-containing residue being attached to said glycerolic backbone via an ether bond:isolating said third compound. to thereby obtain a purified third compound;reacting said purified third compound with an oxidizing agent, to thereby obtain a fourth compound, said fourth compound having a glycerolic backbone and an oxidized moiety-containing residue attached to said glycerolic backbone via an ether bond; andisolating said fourth compound to thereby obtain a purified fourth compound, thereby obtaining the compound having a glycerolic backbone and at least one oxidized moiety-containing residue attached to said glycerolic backbone via an ether bond,the method being devoid of column chromatography.2. The method of claim 1 , wherein isolating said third compound comprises:collecting said third compound;providing a solution of said ...

Подробнее
Номер записи: 15
15-08-2013 дата публикации

Industrial Procedure for the Obtaining of Lower Alcohols From Solar Energy

Номер: US20130210937A1
Автор: Gonzalez Daniel Gonzalez
Принадлежит: GURADOOR, S.L.

The procedure according to the invention allows the obtaining of lower alcohols from the solar energy produced at a high temperature solar thermal power plant which provides, from an energy point of view, the power supply necessary for every step of the procedure, supplying both the electricity power necessary to perform the intermediate steps of the procedure and, essentially, the products involved in the different steps (H, O, steam and CO) starting from a supply of wet milled coal, wherein the by-products obtained during these different stages of the procedure are fed back to the procedure itself. The procedure allows the storage of the energy obtained from the sun as lower alcohols, and such alcohols, in turn, may become an alternative to the consumption of fossil fuels, eliminating the risk derived from the production of residues; consequently, it is an especially advantageous procedure, both from an environmental and a production point of view. 1. Industrial procedure to obtain lower alcohols from solar energy , characterised in that it comprises the following stages:{'sub': 2', '2', '2, 'i) gasification/pyrolysis at a dual reactor, to obtain syngas: the water vapour from a high temperature solar thermal power plant is fed to a dual gasification/pyrolysis reactor where wet milled coal has been previously fed through a feeding hopper, and such coal is partly oxidized by the Oobtained from a subsequent electrolysis stage (stage 2), and by the water vapour from the solar plant at a gasifier provided inside the dual reactor; the gas thus obtained is subsequently subject to a pyrolysis, removing the free carbon, the HS and part of CO, using the appropriate catalysts to obtain syngas.'}{'sub': '2', 'ii) Electrolysis in parallel to obtain hydrogen and oxygen: the mixture of water vapour and residual COobtained at the stage i) passes through a turbine/engine to generate, by means of a dynamo, the power required to unleash an electrolysis reaction at the appropriate ...

Подробнее
Номер записи: 16
15-08-2013 дата публикации

CATALYTIC CONVERSION OF ALCOHOLS AND ALDEHYDES

Номер: US20130211146A1
Автор: Kraft Axel, Menne Andreas
Принадлежит:

The invention provides a process for preparing higher alcohols and/or aldehydes and also mixtures thereof by catalytic reaction of ethanol, the reaction taking place in the presence of at least one catalyst, the catalyst comprising an activated-carbon substrate which is provided with at least one metal, and more particularly has at least one metal dope. 127-. (canceled)28. A process for preparing higher alcohols and aldehydes and mixtures thereof by catalytic reaction of ethanol ,wherein the reaction is carried out in the presence of at least one catalyst comprising an activated carbon substrate which is provided with at least one metal.29. The process as claimed in claim 28 , wherein the higher alcohols and aldehydes are selected from the group consisting of C-C-alcohols and C-C-aldehydes and mixtures thereof.30. The process as claimed in claim 28 , wherein the higher alcohols and aldehydes are selected among linear and branched alcohols and aldehydes and wherein a butanol-containing product mixture results.31. The process as claimed in claim 28 , wherein ethanol is reacted as pure material or else as a mixture of ethanol with at least one further alcohol or with at least one aldehyde.32. The process as claimed in claim 28 , wherein the reaction is carried out in the gas phase and wherein the reaction is carried out at above the boiling points of the starting materials and products.33. The process as claimed in claim 28 , wherein the reaction is carried at temperatures in the range from 150° C. to 600° C.34. The process as claimed in claim 28 , wherein the reaction is carried out using reaction times or contact times in the range from 0.001 to 120 seconds.35. The process as claimed in claim 28 , wherein the process is carried out with a space-time yield claim 28 , calculated as amount of all products formed per catalyst volume and per unit time claim 28 , in the range from 10 to 3000 g/(liter·h).36. The process as claimed in claim 28 , wherein the process is ...

Подробнее
Номер записи: 17
29-08-2013 дата публикации

CHIRAL SPIRO-PYRIDYLAMIDOPHOSPHINE LIGAND COMPOUND, SYNTHESIS METHOD THEREFOR AND APPLICATION THEREOF

Номер: US20130225822A1
Автор: LIU Xiaoyan, Wang Lixin, Xie Jianbo, XIE Jianhua, Zhou Qilin
Принадлежит:

The present invention relates to a chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof. The chiral spiro-pyridylamidophosphine compound is a compound having a structure of Formula (I), a racemate or optical isomer thereof, or a catalytically acceptable salt thereof, and is mainly characterized by having a chiral spiro-dihydro-indene skeleton in its structure. The chiral spiro-pyridylamidophosphine compound may be synthesized with optical active 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene or substituted 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene having a spiro-skeleton as chiral starting material. The chiral spiro-pyridylamidophosphine compound may be used as a chiral ligand in asymmetric hydrogenation of a carbonyl compound catalyzed by iridium, in which the reaction activity is very high, the amount of the catalyst may be 0.0001 mol %, and the enantioselectivity of the reaction is up to 99.9% ee. 2. The chiral spiro-pyridylamidophosphine compound according to claim 1 , or the racemate or optical isomer thereof claim 1 , or the catalytically acceptable salt thereof claim 1 , which is characterized by that in the structural formula of said compound claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , Rare H simultaneously claim 1 , and Ris phenyl or substituted phenyl claim 1 , and the substituent on said substituted phenyl is halogen claim 1 , C-Calkyl or alkoxy claim 1 , with a substituent amount of 1-5; Ris H claim 1 , halogen claim 1 , C-Calkyl claim 1 , C-Calkoxy claim 1 , phenyl claim 1 , substituted phenyl claim 1 , 1-naphthyl claim 1 , 2-naphthyl claim 1 , heteroaryl claim 1 , furyl or thienyl claim 1 , and the substituent on said substituted phenyl is halogen claim 1 , C-Chydrocarbyl or alkoxy claim 1 , with a substituent amount of 1-5 claim 1 , and said heteroaryl is pyridyl claim 1 , and m=0-3; or when m≧2 claim 1 , adjacent Rgroups can ...

Подробнее
Номер записи: 18
10-10-2013 дата публикации

N ortho acyl substituted nitrogen-containing heterocyclic compound and process for preparing aminal iron (ii) complexes thereof

Номер: US20130267708A1
Автор: Chunhong Wu, Haiying Zhang, Hongfei Wu, Huaijie Wang, Jilong Wang, Jun Liu, Lan Zhao, Mingfang Zheng, Qi Yanping, Tonglin Li, Weizhen Li, Wingjun Xie, YU Zhou, Zhiguang Jia
Принадлежит: China Petroleum and Chemical Corp, Sinopec Beijing Research Institute of Chemical Industry

Provided are a process for preparing an N ortho acyl substituted nitrogen-containing heterocyclic compound and an aminal iron (II) complex thereof, and the use of the complexes obtained by the process in an olefin oligomerization catalyst. The N ortho acyl substituted nitrogen-containing heterocyclic compound in the present invention is for example 2-acyl-1,10-phenanthroline or 2,6-diacetyl pyridine as shown in formula b, and the N ortho acyl substituted nitrogen-containing heterocyclic compound in the present invention is produced by a reaction of a precursor thereof in a substituted or unsubstituted nitrobenzene. Preferably the precursor shown in formula I in the present invention is produced by 1,10-phenanthroline reacting with trialkyl aluminum, or a halogenoalkyl aluminum R n AlX m , or a substituted or unsubstituted benzyl lithium 2 Li, followed by hydrolysis. The preparation method provided in the present invention has a few synthetic steps, an easy process, a low toxic effect, and reduces the preparation costs of the catalyst, and has a promising outlook in the industrial application.

Подробнее
Номер записи: 19
10-10-2013 дата публикации

Aromatic ketone synthesis with amide reagents and related reactions

Номер: US20130267712A1
Автор: Douglas A. Klumpp, Erum K. Raja
Принадлежит: Northern Illinois University

A method of preparing an aryl carbonyl or aryl thiocarbonyl compound, comprises reacting an N-(nitroaryl)-amide or N-(nitroaryl)-thioamide with an aromatic ring, with a superacid catalyst, to produce the aryl carbonyl or aryl thiocarbonyl compound. The superacid is present in an amount of at most 8 equivalents in proportion to the N-(nitroaryl)-amide or N-(nitroaryl)-thioamide. A method of preparing aryl amide or aryl thioamide, comprises reacting an N-(nitroaryl)-carbamide or N-(nitroaryl)-thiocarbamide with an aromatic ring, with a superacid catalyst, to produce the aryl amide or aryl thioamide.

Подробнее
Номер записи: 20
17-10-2013 дата публикации

Triazolium Carbene Catalysts and Stereoselective Bond Forming Reactions Thereof

Номер: US20130274470A1
Автор: Rovis Tomislav, Vora Harit U.
Принадлежит:

Provided herein are triazolium carbine catalysts useful for asymmetric hydration, fluorination, and deuteration, and processes for their preparation. Also provided are synthetic reactions in which these catalysts are used, in particular, in stereoselective formation of carbon-chlorine, carbon-hydrogen, carbon-fluorine, and carbon-deuterium bonds. 2. The compound of wherein the counter ion X is selected from the group consisting of BF claim 1 , Cl claim 1 , PF claim 1 , BPh claim 1 , and RBF.3. A composition comprising a compound of formula (I) according to claim 1 , a proton donor claim 1 , and a base.5. The method of claim 4 , wherein the aldehyde is an enal.6. The method of claim 4 , wherein the aldehyde is a α claim 4 ,α-dichloro aldehyde or an α-chloro α-fluoro aldehyde.8. The method of wherein claim 4 , the asymmetric hydration results in an enantiomeric excess of the respective α-deuterio carboxylic acid claim 4 , α-deuterio-α-chloro carboxylic acid or α-deuterio-α-fluoro carboxylic acid.9. The method of further comprising contacting the aldehyde with an additive selected from phase transfer reagents claim 4 , salts claim 4 , and brine.11. The method of claim 10 , wherein the aldehyde is an enal.12. The method of claim 10 , wherein the aldehyde is a α claim 10 ,α-dichloro aldehyde or an α-chloro α-fluoro aldehyde.14. The method of claim 10 , wherein the drug analog is an α-fluoroenal and the asymmetric hydration forms an α-fluoro carboxylic acid.15. The method of claim 10 , wherein the asymmetric hydration results in an enantiomeric excess of the respective drug analog.17. The method of claim 16 , wherein the aldehyde is an enal.18. The method of claim 16 , wherein the aldehyde is a α claim 16 ,α-dichloro aldehyde or an α-chloro α-fluoro aldehyde.20. The method of claim 4 , wherein the base is selected from the group consisting of KCO claim 4 , NaHCO claim 4 , KHPO claim 4 , NaCO claim 4 , KPO claim 4 , EtN claim 4 , DIPEA claim 4 , DBU claim 4 , DBN claim 4 , ...

Подробнее
Номер записи: 21
24-10-2013 дата публикации

Novel ruthenium complexes and their uses in processes for formation and/or hydrogenation of esters, amides and derivatives thereof

Номер: US20130281664A1
Автор: Boopathy Gnanaprakasam, Chidambaram Gunanathan, David Milstein, Ekambaram Balaraman, Jing Zhang
Принадлежит: Yeda Research and Development Co Ltd

The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to the novel uses of certain pyridine Ruthenium catalysts.

Подробнее
Номер записи: 22
24-10-2013 дата публикации

Compounds for the treatment of metabolic disorders

Номер: US20130281705A1
Автор: Shalini Sharma
Принадлежит: Wellstat Therapeutics Corp

Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.

Подробнее
Номер записи: 23
14-11-2013 дата публикации

PROCESS FOR PRODUCTION OF AROMATIC ALCOHOL OR HETEROCYCLIC AROMATIC ALCOHOL

Номер: US20130303775A1
Автор: ABE Takafumi, Fushimi Norio, Kanbara Yutaka
Принадлежит: MITSUBISHI GAS CHEMICAL COMPANY, INC.

A process of production of an aromatic alcohol or a heterocyclic aromatic alcohol, containing a step of reacting an aromatic amine or a heterocyclic aromatic amine having an aromatic ring or a heterocyclic aromatic ring having thereon at least one substituent —CHRNRR(wherein R, Rand Reach independently represent hydrogen, an alkyl group having from 1 to 4 carbon atoms, or a benzyl group), with an alcohol, in the presence of a basic catalyst. 1. A process for producing an aromatic alcohol or a heterocyclic aromatic alcohol , the process comprising reacting an aromatic amine or a heterocyclic aromatic amine , comprising at least one substituent —CHRNRR , with an alcohol , in the presence of a basic catalyst ,{'sup': 1', '2', '3, 'wherein R, Rand Reach independently represent hydrogen, an alkyl group having from 1 to 4 carbon atoms, or a benzyl group.'}4. The process of claim 1 , wherein the basic catalyst is at least one selected from the group consisting of metallic sodium claim 1 , metallic potassium claim 1 , a sodium compound and a potassium compound.5. The process of claim 1 , wherein the alcohol is an alcohol having a linear or branched alkyl group having from 1 to 11 carbon atoms claim 1 , a cycloalkyl group having from 3 to 8 carbon atoms claim 1 , or an alkyl group having from 1 to 3 carbon atoms having a phenyl group substituted thereon claim 1 , having a hydroxyl group bonded thereto.6. The process of claim 1 , wherein water is added to the reaction.7. The process of claim 1 , wherein ammonia is added to the reaction.8. The process of claim 2 , wherein the basic catalyst is at least one selected from the group consisting of metallic sodium claim 2 , metallic potassium claim 2 , a sodium compound and a potassium compound.9. The process of claim 2 , wherein the alcohol is an alcohol having a linear or branched alkyl group having from 1 to 11 carbon atoms claim 2 , a cycloalkyl group having from 3 to 8 carbon atoms claim 2 , or an alkyl group having from 1 to ...

Подробнее
Номер записи: 24
26-12-2013 дата публикации

PROCESS AND INTERMEDIATE COMPOUNDS USEFUL IN THE PREPARATION OF STATINS

Номер: US20130345429A1
Автор: Moody David John, Wiffen Jonathan William
Принадлежит:

There is provides a process for the preparation of a compound of formula (7): wherein R is an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; provides that R is not a compound of Formula (a): wherein Rrepresents an alkyl group, such as a Calkyl group, and preferably an isopropyl group; Rrepresents an aryl group, preferably a 4-fluorophenyl group; Rrepresents hydrogen, a protecting group or an alkyl group, such as a Calkyl group, and preferably a methyl group; and Rd represents hydrogen, a protecting group or a SORgroup where Ris an alkyl group, such as a Calkyl group, and preferably a methyl group. 17-. (canceled)9. The process of wherein Y is Cl or Br.11. The process of claim 10 , wherein Ris an alkyl group and/or Ris an alkanoyl group.12. The process of claim 11 , wherein Ris a Calkyl group and/or Ris a Calkanoyl group.13. The process of claim 12 , wherein Ris a —C(O)CH(Me)CHCHor —C(O)C(Me)CHCHgroup14. The process of claim 10 , wherein Ris an alkanoyl group.15. The process of claim 14 , wherein Ris a Calkanoyl group16. The process of claim 14 , wherein Ris a —C(O)CH(Me)CHCHor a —C(O)C(Me)CHCHgroup.17. The process of claim 10 , wherein Ris a substituted or unsubstituted aryl group and/or Ris a substituted or unsubstituted alkyl group.18. The process of claim 17 , wherein Ris a 4-fluorophenyl group and/or Ris a cyclopropyl group.19. The process of claim 10 , wherein Ris a substituted or unsubstituted aryl group and/or Ris a substituted or unsubstituted alkyl group.20. The process of claim 19 , wherein Ris a 4-fluorophenyl group and/or Ris an isopropyl group.21. The process of claim 10 , wherein Ris a substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group; Ris a substituted or unsubstituted aryl group; and/or Ris a substituted or unsubstituted aryl group.22. The process of claim 21 , wherein Ris a methyltetrazoyl group; Ris a 4-fluorophenyl group; and/or Ris a 4-fluorophenyl group.23. ...

Подробнее
Номер записи: 25
26-12-2013 дата публикации

METHOD AND SYSTEM FOR LIQUID PHASE REACTIONS USING HIGH SHEAR

Номер: US20130345472A1
Автор: Anthony Rayford G., Borsinger Gregory, HASSAN Abbas, Hassan Aziz
Принадлежит: H R D Corporation

A method of reacting one or more components in a liquid phase to form an organic product, the method including feeding a carbon-based gas to a high shear device; feeding a hydrogen-based liquid medium to the high shear device; using the high shear device to form a dispersion comprising the carbon-based gas and the hydrogen-based liquid medium, wherein the dispersion comprises gas bubbles with a mean diameter of less than about 5 μm; introducing the dispersion into a reactor; and reacting the dispersion to produce the organic product. 1. A method of reacting one or more components in a liquid phase to form an organic product , the method comprising:(a) feeding a carbon-based gas to a high shear device, the high shear device comprising a shear gap;(b) feeding a hydrogen-based liquid medium to the high shear device;(c) using the high shear device to form a dispersion comprising the carbon-based gas and the hydrogen-based liquid medium, wherein the dispersion comprises gas bubbles with a mean diameter of less than about 1 μm; and(d) reacting the dispersion to produce the organic product.2. The method of claim 1 , wherein the high shear device produces a local pressure of at least about 1034.2 MPa (150 claim 1 ,000 psi) at the tip of a first rotor disposed therein.3. The method of wherein the organic product comprises alkanes claim 2 , olefins claim 2 , aromatics claim 2 , or combinations thereof.4. The method of claim 1 , wherein the carbon-based gas comprises carbon monoxide and the hydrogen-based liquid medium comprises methanol claim 1 , an ether claim 1 , or an oxide.5. The method of claim 4 , wherein the organic product comprises acetic acid.6. The method of claim 1 , wherein the method further comprises feeding hydrogen to the high shear device claim 1 , the hydrogen-based liquid medium comprises acetic acid claim 1 , and the organic product comprises ethanol.7. The method of further comprising utilizing a catalyst to promote the formation of the organic product.8 ...

Подробнее
Номер записи: 26
27-02-2014 дата публикации

PRODUCTION OF OXYGENATES FROM A METHANE CONVERSION PROCESS

Номер: US20140058135A1
Автор: Bricker Jeffery C., Chen John Q., Coughlin Peter K.
Принадлежит:

Methods and systems are provided for converting methane in a feed stream to acetylene. The method includes processing acetylene as an intermediate stream to form a stream having oxygenates. The hydrocarbon stream is introduced into a supersonic reactor and pyrolyzed to convert at least a portion of the methane to acetylene. The reactor effluent stream may be treated to convert acetylene to oxygenates through subsequent reactors. 1. A method for producing aldehydes comprising:introducing a feed stream comprising methane into a supersonic reactor;converting the methane in the supersonic reactor to form a reactor effluent stream comprising acetylene;passing the reactor effluent stream to a hydrogenation reactor at hydrogenation reaction conditions to form a second effluent stream comprising olefins; andpassing the second effluent stream to an aldehyde conversion reactor at aldehyde conversion reaction conditions to form an effluent stream comprising aldehydes.2. The method of further comprising:passing the second effluent stream to an oligomerization reactor to generate an oligomerization effluent stream; andpassing the oligomerization effluent stream to the aldehyde conversion reactor, to generate an effluent stream comprising C4+ aldehydes.3. The method of further comprising passing an oxygen stream comprising oxygen to the aldehyde conversion reactor.4. The method of wherein the aldehyde reaction conditions include an aldehyde conversion catalyst.5. The method of wherein the oxidation catalyst is a metal chloride. (PdCl2 claim 4 , CuCl2).6. The method of further comprising passing a second stream comprising water to the aldehyde conversion reactor.7. The method of wherein the aldehyde conversion reaction conditions include basic reaction conditions over a catalyst.8. The method of wherein in the basic reaction conditions include the addition of an alkali compound.9. The method of wherein the conversion reaction in the supersonic reactor is a pyrolysis reaction.10. A ...

Подробнее
Номер записи: 27
10-04-2014 дата публикации

PEPTOID COMPOSITIONS AND METHODS OF USING THE SAME

Номер: US20140100354A1
Автор: Kirshenbaum Kent, Maayan Galia, Ward Michael
Принадлежит:

Novel peptoids are disclosed that have a formula represented by the following formulae Ia and Ib: 2. The method according to claim 1 , wherein 10-60% of the monomers are of formula III at the same time.3. (canceled)4. (canceled)5. (canceled)6. The method of claim 1 , wherein Ris alkyl substituted with phenyl claim 1 , naphthyl claim 1 , alkoxy claim 1 , or azido.7. (canceled)8. (canceled)9. (canceled)10. (canceled)11. (canceled)12. (canceled)13. (canceled)14. (canceled)15. (canceled)16. (canceled)17. (canceled)18. (canceled)19. (canceled)20. (canceled)21. (canceled)22. (canceled)25. (canceled)26. The method of claim 1 , wherein L is a single bond.27. (canceled)28. The method of claim 1 , wherein L is —CH—CH—O—.29. The method of claim 1 , wherein Ris 8-hydroxyquinolinyl claim 1 , phenanthrolinyl claim 1 , terpyridinyl claim 1 , amino claim 1 , carboxy claim 1 , sulfhydryl claim 1 , imidazolyl claim 1 , or phosphinyl claim 1 , or metal complexes thereof.31. The method of claim 1 , wherein Ris —SH claim 1 , or —CH(Me)NH.32. The method of claim 1 , wherein Ris a nitroxide containing group.34. The method of claim 1 , wherein Ris nitroxide containing heterocycloalkyl claim 1 , or nitroxide containing heteroaryl.36. (canceled)37. (canceled)39. The method of claim 1 , wherein n is 3-20.40. (canceled)41. (canceled)42. The method of claim 1 , wherein X is H or Ac.43. (canceled)44. The method of claim 1 , wherein Y is OH claim 1 , OAc claim 1 , NHor NHAc.45. (canceled)46. (canceled)47. The method of claim 38 , wherein n is 2-11; one monomer is of formula III; and the other monomers are independently selected from Npm claim 38 , Nme claim 38 , Nspm claim 38 , Naz claim 38 , Nyl claim 38 , Nspe claim 38 , Nrpe claim 38 , Nsch claim 38 , and Nrch.48. (canceled)49. The method of claim 38 , wherein n is 3 claim 38 , 4 claim 38 , 5 claim 38 , 6 claim 38 , 7 claim 38 , or 9; and the peptoid is selected from the group consisting of H—N(L-R)CHC(O)—(Nspe)-NH; H-(Nspe)-N(L-R)CHC(O)—(Nspe ...

Подробнее
Номер записи: 28
07-01-2021 дата публикации

METHOD FOR PRODUCING CARBONYL COMPOUND

Номер: US20210002199A1
Автор: Higashi Masahiro, ISHIHARA Sumi, KISHIKAWA Yosuke, Yoneda Satoru
Принадлежит: DAIKIN INDUSTRIES, LTD.

A method for producing a carbonyl compound represented by formula (1): 2. The production method according to claim 1 , wherein Rand Rare independently hydrogen claim 1 , Calkyl optionally having at least one substituent claim 1 , Caromatic group optionally having at least one substituent claim 1 , or a Cheterocyclic group optionally having at least one substituent.3. The production method according to claim 2 , wherein Rand Rare independently hydrogen; Calkyl optionally having at least one substituent claim 2 , wherein the at least one substituent is independently selected from the group consisting of hydroxyl claim 2 , amino claim 2 , carboxyl claim 2 , sulfonic acid claim 2 , phosphonic acid claim 2 , and salts thereof claim 2 , a Caromatic group optionally having at least one substituent; or a Cheterocyclic group optionally having at least one substituent.4. The production method according to claim 1 , wherein Ris hydrogen; Calkyl optionally having at least one substituent; a Caromatic group optionally having at least one substituent; or a Cheterocyclic group optionally having at least one substituent.5. The production method according to claim 4 , wherein Ris hydrogen; Calkyl optionally having at least one substituent claim 4 , wherein the at least one substituent is independently selected from the group consisting of hydroxyl claim 4 , amino claim 4 , carboxyl claim 4 , sulfonic acid claim 4 , phosphonic acid claim 4 , and salts thereof claim 4 , a Caromatic group optionally having at least one substituent; or a Cheterocyclic group optionally having at least one substituent.6. The production method according to claim 1 , wherein the non-alcohol organic solvent (a) is at least one solvent selected from the group consisting of amide solvents claim 1 , ether solvents claim 1 , nitrile solvents claim 1 , sulfoxide solvents claim 1 , aromatic solvents claim 1 , ester solvents claim 1 , ketone solvents claim 1 , fluorine-based solvents claim 1 , carbonate solvents ...

Подробнее
Номер записи: 29
07-01-2016 дата публикации

ZINC COMPLEX

Номер: US20160002268A1
Автор: MATSUSHIMA Yoshimasa, OHSHIMA Takashi, YAZAKI Ryo, YOKOTE Yuki
Принадлежит: TAKASAGO INTERNATIONAL CORPORATION

A zinc complex characterized in exhibiting an octahedral structure and being configured from repeating units represented by general formula (I): 4. A catalyst comprising the zinc complex according to .5. A method for acylating a hydroxy group claim 1 , comprising{'claim-ref': {'@idref': 'CLM-00004', 'claim 4'}, 'reacting a carboxylic acid or an ester thereof in the presence of the catalyst according to .'}6. A method for converting a hydroxy group to a carbonate claim 1 , comprising{'claim-ref': {'@idref': 'CLM-00004', 'claim 4'}, 'reacting a carbonate ester in the presence of the catalyst according to .'}7. A method for deacylating a carboxylate ester claim 1 , comprising{'claim-ref': {'@idref': 'CLM-00004', 'claim 4'}, 'deacylating the carboxylate ester in the presence of the catalyst according to .'}13. A catalyst comprising the zinc complex according to .14. A method for acylating a hydroxy group claim 2 , comprising{'claim-ref': {'@idref': 'CLM-00013', 'claim 13'}, 'reacting a carboxylic acid or an ester thereof in the presence of the catalyst according to .'}15. A method for converting a hydroxy group to a carbonate claim 2 , comprising{'claim-ref': {'@idref': 'CLM-00013', 'claim 13'}, 'reacting a carbonate ester in the presence of the catalyst according to .'}16. A method for deacylating a carboxylate ester claim 2 , comprising{'claim-ref': {'@idref': 'CLM-00013', 'claim 13'}, 'deacylating the carboxylate ester in the presence of the catalyst according to .'} The present invention relates to a novel zinc complex useful as a catalyst for various reactions including transesterification reaction and the like.A lot of multinuclear metal complexes having multiple metal nuclei in each molecule have been developed as highly active catalysts. Of these catalysts, a catalyst comprising a trifluoroacetate-bridged tetranuclear zinc cluster complex containing four zinc ions in a molecule is an excellent catalyst which promotes various reactions such as transesterification ...

Подробнее
Номер записи: 30
02-01-2020 дата публикации

METHOD FOR THE PRODUCTION OF 2,4-DIHYDROXYBUTYRIC ACID

Номер: US20200002260A1
Автор: Genders David, Stapley Jonathan
Принадлежит: DFI USA, LLC

Methods for the production of 2,4-dihydroxybutyrate (2,4-DHB) from erythrose and other four-carbon sugars are disclosed. The improved methods facilitate the production of 2,4-DHB that is a precursor for biorenewable and animal nutrition chemicals among others. 1. A method of producing 2 ,4-dihydroxybutyrate , comprising: mixing a four carbon sugar and a hydroxide salt in solution , wherein the four carbon sugar is erythrulose.2. The method of claim 1 , wherein the temperature of the solution is maintained below 100° C.3. The method of claim 1 , wherein the four carbon sugar is diluted sufficiently to result in a molar yield of DHB that is greater than 40%.4. The method of claim 1 , wherein the four carbon sugar is diluted with a solution containing DHB.5. The method of claim 1 , wherein the method is performed in a continuous reactor system.6. The method of claim 1 , wherein the hydroxide concentration of the solution is between 0.1 M and 4 M.7. The method of claim 6 , wherein the temperature of the solution is maintained below 100° C.8. The method of claim 7 , wherein the four carbon sugar is diluted with a solution containing DHB.9. The method of claim 1 , further comprising removing oxygen from the solution.10. The method of claim 9 , wherein oxygen is removed by venting the solution with a gas selected from the group consisting of: nitrogen claim 9 , argon claim 9 , and mixtures thereof.11. The method of claim 9 , wherein oxygen is removed by venting the solution with hydrogen.12. The method of claim 11 , wherein the temperature of the solution is maintained below 100° C.13. The method of claim 12 , wherein the erythrulose is diluted with a solution containing one or more other organic acid salts.14. The method of claim 13 , wherein the method is performed in a continuous reactor system.15. A method of producing 2 claim 13 ,4-dihydroxybutyrate claim 13 , comprising:mixing a four carbon sugar and a hydroxide salt in solution; andremoving oxygen from the solution ...

Подробнее
Номер записи: 31
16-01-2020 дата публикации

Process for producing 2-butanol from gammavalerolactone

Номер: US20200017430A1
Автор: Kaisa Lamminpää, Marina Lindblad, Mats KÄLDSTRÖM, Susanna WALLENIUS
Принадлежит: Neste Oyj

A process is disclosed for selectively producing 2-butanol from GVL by using at least one transition metal catalyst selected from the group consisting of iron, ruthenium, cobalt, rhodium and iridium.

Подробнее
Номер записи: 32
24-01-2019 дата публикации

PROCESS FOR THE EPOXIDATION OF AN OLEFIN

Номер: US20190023673A1
Автор: DAUTH Nico, PASCALY Matthias, Schmidt Franz
Принадлежит:

In a process for the epoxidation of an olefin with hydrogen peroxide in the presence of a solvent, where a mixture comprising olefin, an aqueous hydrogen peroxide solution and a solvent is continuously passed through a fixed bed of an epoxidation catalyst comprising a titanium zeolite, addition of a chelating agent to the aqueous hydrogen peroxide solution before mixing it with solvent reduces or prevents formation of deposits on the catalyst and blocking of orifices of a liquid distributor. 114-. (canceled)15. A process for the epoxidation of an olefin with hydrogen peroxide in the presence of a solvent , wherein the solvent is selected from the group consisting of methanol , ethanol , tert-butanol , ethylene glycol , 1 ,2-propanediol , 1 ,3-propanediol , tetrahydrofuran , dioxane , ethylene glycol monomethyl ether , ethylene glycol monoethyl ether , ethylene glycol monobutyl ether , propylene glycol monomethyl ethers , acetone , 2-butanone , acetonitrile and proprionitrile , hydrogen peroxide is used as an aqueous hydrogen peroxide solution , a chelating agent is added to the aqueous hydrogen peroxide solution before it is mixed with solvent , and a mixture comprising olefin , solvent , and hydrogen peroxide with added chelating agent is continuously passed through a fixed bed of an epoxidation catalyst comprising a titanium zeolite.16. The process of claim 15 , wherein the aqueous hydrogen peroxide solution comprises phosphoric acid or an alkali metal or ammonium salt of phosphoric acid.17. The process of claim 15 , wherein the aqueous hydrogen peroxide solution is mixed with at least 50% of the solvent used for reacting the olefin with hydrogen peroxide.18. The process of claim 15 , wherein the chelating agent is a polyphosphonic acid or an alkali metal or ammonium salt thereof.19. The process of claim 15 , wherein the chelating agent is added in an amount of from 10to 10mol chelating agent per mol of hydrogen peroxide.20. The process of claim 15 , wherein the ...

Подробнее
Номер записи: 33
28-01-2021 дата публикации

Zwitterionic catalysts for (trans)esterification: application in fluoroindole-derivatives and biodiesel synthesis

Номер: US20210023539A1
Автор: Fei Tan, Wing-Hin NG, Xinyan WANG, Ying-Lung Steve TSE, Ying-Pong LAM, Ying-Yeung YEUNG, Zhihai KE
Принадлежит: Chinese University of Hong Kong CUHK

An amide/iminium zwitterion catalyst has a catalyst pocket size that promotes transesterification and dehydrative esterification. The amide/iminium zwitterions are easily prepared by reacting aziridines with aminopyridines. The reaction can be applied a wide variety of esterification processes including the large-scale synthesis of biodiesel. The amide/iminium zwitterions allow the avoidance of strongly basic or acidic condition and avoidance of metal contamination in the products. Reactions are carried out at ambient or only modestly elevated temperatures. The amide/iminium zwitterion catalyst is easily recycled and reactions proceed in high to quantitative yields.

Подробнее
Номер записи: 34
01-02-2018 дата публикации

PREPARATION OF COMPOUNDS FROM LEVULINIC ACID

Номер: US20180029980A1
Автор: Dutta Saikat, Mascal Mark, Wu Linglin
Принадлежит:

The present invention provides a method of making carboxylic acids from levulinic acid, such as succinic acid and 3-hydroxypropanoic acid, by reacting levulinic acid with an oxidant such as hydrogen peroxide under acidic or basic conditions. 1. A method of preparing a carboxylic acid , comprising:forming a reaction mixture comprising levulinic acid, an oxidant, and an acid or a base, under conditions suitable to prepare the carboxylic acid.3. The method of claim 1 , wherein the oxidant is hydrogen peroxide.4. The method of claim 3 , wherein the reaction mixture is substantially free of an oxidizing metal catalyst.5. The method of claim 1 , wherein the carboxylic acid is succinic acid.6. The method of claim 5 , the method comprising:forming the reaction mixture comprising levulinic acid, the oxidant and an acid, thereby preparing the succinic acid.7. The method of claim 5 , the method comprising:forming the reaction mixture comprising levulinic acid, the oxidant and an acid; andheating the reaction mixture at a temperature of from about 30° C. to about 100° C., thereby preparing the succinic acid.8. The method of claim 7 , wherein the acid is selected from the group consisting of hydrofluoric acid claim 7 , hydrochloric acid claim 7 , hydrobromic acid claim 7 , hypochloric acid claim 7 , sulfuric acid claim 7 , nitric acid claim 7 , phosphoric acid claim 7 , hexafluorophosphoric acid claim 7 , methanesulfonic acid claim 7 , benzenesulfonic acid claim 7 , p-toluenesulfonic acid claim 7 , trifluoromethanesulfonic acid claim 7 , fluoroacetic acid claim 7 , and trifluoroacetic acid.9. The method of claim 7 , wherein the acid is trifluoroacetic acid.10. The method of claim 7 , wherein the method comprises:forming the reaction mixture comprising levulinic acid, trifluoroacetic acid, and hydrogen peroxide; andheating the reaction mixture at a temperature of from about 50° C. to about 100° C., thereby preparing succinic acid.11. The method of claim 1 , wherein the carboxylic ...

Подробнее
Номер записи: 35
04-02-2021 дата публикации

DIFLUOROMETHOXYLATION AND TRIFLUOROMETHOXYLATION COMPOSITIONS AND METHODS FOR SYNTHESIZING SAME

Номер: US20210032181A1
Автор: Lee Johnny, Ngai Ming-Yu, ZHENG Weijia
Принадлежит: The Research Foundation for The State University of New York

The present invention provides a compound having the structure: 2. The compound of claim 1 ,wherein{'sub': 1', '1', '2', '2', '3', '3', '4', '4, 'claim-text': {'sub': 1', '2', '3', '4', '3', '2', '2', '3', '2, 'wherein X, X, Xand Xare each, independently, —H, halogen, —CF, —NO, —SOMe, —CN, —OCFor —OCFH;'}, 'Yis N or C—X, Yis N or C—X, Yis N or C—Xand Yis N or C—X,'}{'sub': 5', '5, 'sup': '+', 'claim-text': {'sub': '5', 'wherein Xis alkyl;'}, 'Yis N or N—X,'}{'sub': 6', '6, 'claim-text': {'sub': '6', 'wherein Xis substituted aryl or substituted heteroaryl;'}, 'Yis N or C—X,'}{'sub': 7', '3', '2, 'Xis CFor CFH; and'}{'sub': 4', '4', '6', '6', '2', '7', '2', '7', '4', '8', '9, 'claim-text': {'sub': 7', '8', '9, 'wherein R, R, and Rare each, independently, —H, -(alkyl), -(aryl), -(heteroaryl),'}, 'Z is OTf, BF, B(aryl), SbF, PF, halogen, —OS(O)OR, —OS(O)—R, ClOor —OP (O) (OR)(OR),'}{'sub': 6', '5', '5', '6', '6', '5, 'sup': −', '−', '−, 'wherein when Yis N, then Yis N—Xand Z is present, and when Yis C—X, then Yis N and Z is absent;'}orwherein{'sub': 1', '1', '2', '2', '3', '3', '4', '4, 'claim-text': {'sub': 1', '2', '3', '4', '3', '2', '2, 'wherein X, X, Xand Xare each, independently, —H, —Cl, —Br, —F, —CF, —NOor —SOMe'}, 'Yis N or C—X, Yis N or C—X, Yis N or C—Xand Yis N or C—X,'}{'sub': 5', '5, 'sup': '+', 'claim-text': {'sub': '5', 'wherein Xis alkyl;'}, 'Yis N or N—X,'}{'sub': 6', '6, 'claim-text': {'sub': '6', 'wherein Xis substituted aryl;'}, 'Yis N or C—X,'}{'sub': 7', '3', '2, 'Xis CFor CFH; and'}{'sub': 4', '4', '6', '6', '2', '7', '2', '7', '4', '8', '9, 'claim-text': {'sub': 7', '8', '9, 'wherein R, R, and Rare each, independently, —H, -(alkyl), -(aryl), -(heteroaryl),'}, 'Z is OTf, BF, B(aryl), SbF, PF, halogen, —OS (O)OR, —OS(O)—R, ClOor —OP (O) (OR)(OR),'}{'sub': 6', '5', '5', '6', '6', '5, 'sup': +', '−', '−, 'wherein when Yis N, then Yis N—Xand Z is present, and when Yis C—X, then Yis N and Z is absent.'}3. (canceled)4. The compound of claim 1 ,wherein ...

Подробнее
Номер записи: 36
11-02-2016 дата публикации

NITRIC ACID OXIDATION PROCESSES

Номер: US20160039735A1
Автор: Donen Steven, Hash Kirk, Jensen Keith, Smith Tyler
Принадлежит:

A process utilizing nitric acid and oxygen as co-oxidants to oxidize aldehydes, alcohols, polyols, preferably carbohydrates, specifically reducing sugars to produce the corresponding carboxylic acids. 1. A method of synthesizing a mixture of organic acids , the method comprising the steps of:(a) combining, over time, in one or more closed reaction vessels, under a positive pressure of oxygen and with continuous stirring mixing an organic compound suitable for nitric acid oxidation and an aqueous solution of nitric acid to form a reaction mixture, wherein the organic compound and the aqueous solution of nitric acid are concurrently introduced into the one or more closed reaction vessels;(b) flowing said reaction mixture through the one or more closed reaction vessels while (i) maintaining a controlled temperature of from about 5° C. to about 105° C. in a portion of the reaction vessel, (ii) maintaining a reaction vessel headspace temperature of from about 80° C. to about −42° C.; and (iii) a controlled positive pressure of oxygen of from about 0 barg to about 1000 barg for a time period suitable to oxidize the organic compound to a subsequent reaction mixture comprising a mixture of organic acid products and nitrogen oxides; and(c) removing most of nitric acid from the subsequent reaction mixture to give a final reaction mixture of organic acids suitable for further processing.2. The method of claim 1 , wherein the one or more closed reaction vessels comprises one or more reactors.3. The method of claim 2 , wherein the one or more closed reaction vessels are in series (continuous) or in parallel (batch) with one another.4. The method of claim 2 , wherein the reactor is a continuously stirred tank reactor (CSTRs) or a tubular type plug flow reactor.5. The method of claim 1 , wherein the method is a continuous process.6. The method of claim 1 , wherein the method is a batch process.7. The method of claim 1 , wherein the organic compound comprises a single organic ...

Подробнее
Номер записи: 37
06-02-2020 дата публикации

Treatment of quarry liquid effluent

Номер: US20200039856A1
Автор: Claude Grison
Принадлежит: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Disclosed is a method for preparing a solid material including manganese, the method including the following steps: a. bringing into contact an aqueous effluent including manganese, for example at least 5 mg/L, typically at least 5 to 50 mg/L, and preferably 7 to 25 mg/L of manganese, with an oxidizing agent, manganese, preferably at a temperature between 10° C. and 50° C., and obtaining an oxidized aqueous solution; b. adding a base to the oxidized aqueous solution obtained at the end of step a) until a pH of between 8 and 12, preferably greater than 9, and preferably from 9 to 10.5, and obtaining a solution including a precipitate; c. filtration of the solution obtained at the end of step b); and d. obtaining a solid material including manganese, and especially manganese (IV) and/or Mn (III).

Подробнее
Номер записи: 38
15-02-2018 дата публикации

METHOD FOR PRODUCING POWDERED LAUROYL PEROXIDE

Номер: US20180044289A1
Автор: HERMANN Dominik, Nagl Iris, WOLF Hanno
Принадлежит:

The present application relates to a method for producing powdered lauroyl peroxide which is characterised in that a reaction mixture is used which comprises water, lauric acid chloride, hydrogen peroxide, an inorganic base and an alkane. 1. Method for producing powdered lauroyl peroxide having a particle size according to the d90 value of from 50 μm to 400 μm , wherein a reaction mixture is used which comprises water , lauric acid chloride , hydrogen peroxide , an inorganic base and an alkane , and the method is carried out at a predetermined temperature in the range of from approximately 10° C. to approximately 30° C. , the lauroyl peroxide not being heated above the melting point thereof during the method.2. Method according to claim 1 , wherein production of lauroyl peroxide is carried out in the aqueous phase.3. (canceled)4. Method according to claim 1 , wherein the method is carried out at a predetermined temperature in the range of from approximately 15° C. to approximately 20° C.5. Method according to claim 1 , wherein the alkane is selected from the group consisting of straight-chain alkanes claim 1 , branched-chain alkanes claim 1 , cyclic alkanes claim 1 ,. and mixtures thereof.6. Method according to claim 1 , wherein the alkane is a C-alkane.7. Method according to claim 1 , wherein an aqueous solution of sodium hydroxide claim 1 , potassium hydroxide claim 1 , or mixtures thereof claim 1 , is used as the inorganic base.8. Method according to claim 1 , wherein a molar excess of hydrogen peroxide above a theoretically required amount in the reaction mixture is from approximately 30% to approximately 80%.9. Method according to claim 1 , wherein a mass ratio of alkane to lauric acid chloride in the reaction mixture is in the range of from approximately 1:10 to approximately 1:1.10. Method according to claim 1 , wherein the reaction mixture comprises further components selected from the group consisting of stabilisers for the hydrogen peroxide claim 1 , ...

Подробнее
Номер записи: 39
16-02-2017 дата публикации

METHODS FOR PRODUCING ALKYLBENZENES, PARAFFINS, OLEFINS AND OXO ALCOHOLS FROM WASTE PLASTIC FEEDSTOCKS

Номер: US20170044465A1
Автор: Cron Scott Leroy, Scheibel Jeffrey John, VINSON Phillip Kyle, WILLIAMS Thomas Earl
Принадлежит:

The present invention relates generally to methods for producing detergent compounds from waste plastic feedstocks. More specifically, the invention relates to methods for producing detergent intermediates, including alkylbenzenes, paraffins, olefins, oxo alcohols, and surfactant derivatives thereof from waste plastic feedstock. 1. A method for producing paraffin from waste plastic feedstock and kerosene and/or another source(s) of hydrocarbons comprising the steps of:providing a first feed stream comprising kerosene and/or another source(s) of hydrocarbons;pre-fractionating the first feed stream to produce a first heart cut paraffin stream comprising paraffins in a heart cut range;combining the first heart cut paraffin stream with a second feed stream comprising waste plastic feedstock to form a combined stream;hydrotreating the combined stream; andfractionating the hydrotreated stream to remove paraffins that are heavier and/or lighter than the heart cut range to form a second heart cut paraffin stream.2. The method according to claim 1 , further comprising the step of separating branched and cyclic hydrocarbons from the second heart cut paraffin stream to form a linear heart cut paraffin stream.3. The method according to claim 1 , further comprising the step of separating branched and cyclic hydrocarbons from the combined stream to form a linear combined stream.4. A method for producing paraffin from waste plastic feedstock and kerosene and/or another source(s) of hydrocarbons comprising the steps of:providing a first feed stream comprising kerosene and/or another source(s) of hydrocarbons;pre-fractionating the first feed stream to produce a first heart cut paraffin stream comprising paraffins in a heart cut range;hydrotreating a second feed stream comprising waste plastic feedstock;combining the first heart cut paraffin stream with the hydrotreated second feed stream to form a combined stream;hydrotreating the combined stream; andfractionating the hydrotreated ...

Подробнее
Номер записи: 40
13-02-2020 дата публикации

METHOD FOR THE PRODUCTION OF A MATERIAL OF PLANT ORIGIN THAT IS RICH IN PHENOLIC ACIDS, COMPRISING AT LEAST ONE METAL, FOR CARRYING OUT ORGANIC SYNTHESIS REACTIONS

Номер: US20200047165A1
Автор: CARRASCO David, GRISON Claude, STANOVYCH Andrii
Принадлежит:

Disclosed is a method for preparing a material of plant origin rich in phenolic acids, including at least one metal, including: preparing a material of plant origin chosen from: aquatic plants; materials rich in tannins; materials rich in lignin; and obtaining a material of plant origin, rich in phenolic acids, in which the ratio of the intensity of the vibration band of the C═O bond of the COOH group and the intensity of each of the vibration bands the aromatic ring determined in FT-IR is between 0.5 and 4. The material of plant origin is brought into contact with an effluent including from 0.1 to 1000 mg/l of at least one metal, thus obtaining a material of plant origin rich in phenolic acids including from 1 to 30% by weight of at least one metal relative to the total weight of the material. 1. Method for preparing a material of plant origin rich in phenolic acids , comprising at least one metal , said method comprising the following steps: aquatic plants;', 'materials rich in tannins;', 'materials rich in lignin; and, 'a. preparation of a material of plant origin from a dead plant chosen fromobtaining a material of plant origin, rich in phenolic acids, in which the ratio of the intensity of the vibration band of the C═O bond of the COOH group and the intensity of each of the vibration bands the aromatic ring determined in FT-IR is between 0.5 and 4, preferably between 1 and 3.5, for example between 1 and 2.5;b. bringing into contact the material of plant origin obtained at the end of step a) with an effluent comprising from 0.1 to 1000 mg/l of at least one metal; andc. obtaining a material of plant origin rich in phenolic acids comprising from 1 to 30% by weight of at least one metal relative to the total weight of the material.2. Method for the decontamination or treatment of an effluent comprising at least one metal , said method comprising the following steps: aquatic plants;', 'materials rich in tannins;', 'materials rich in lignin; and, 'a. preparation of a ...

Подробнее
Номер записи: 41
08-05-2014 дата публикации

Process for the Oxidation of Organic Carbonyl Compounds

Номер: US20140128622A1
Автор: Müller Ulrich, Parvulescu Andrei-Nicolae, Teles Joaquim Henrique, Vautravers Nicolas
Принадлежит: BASF SE

A process for the oxidation of an organic carbonyl compound comprising reacting the organic carbonyl compound, optionally in the presence of a solvent, with hydrogen peroxide in the presence of a catalyst comprising a tin-containing zeolitic material having an MWW-type framework structure. 2. The process of claim 1 , wherein Rand Rare independently from one another a linear or branched alkyl residue having from 1 to 20 carbon atoms claim 1 , a linear or branched alkenyl residue having from 2 to 20 carbon atoms claim 1 , an aryl or heteroaryl residue having from 4 to 20 carbon atoms claim 1 , or a hydrogen atom and wherein claim 1 , if neither Rnor Ris a hydrogen atom claim 1 , Rand Rmay form claim 1 , together with the carbonyl group or the carboxyl group claim 1 , a ring having from 4 to 20 carbon atoms.3. The process of claim 1 , wherein the compound of formula (I) contains at least one C—C double bond.4. The process of claim 3 , wherein the compound of formula (I) contains a C—C double bond in alpha position to the carbonyl group.5. The process of claim 1 , wherein at least 99 weight-% of the framework structure of the Sn-MWW consist of BOand SiO claim 1 , wherein the molar ratio of BOrelative to SiOis in the range of from 0.0005:1 to 0.0025:1.6. The process of claim 1 , wherein the Sn-MWW has a tin content in the range of from 0.1 to 4.0 weight-% claim 1 , calculated as element and based on the weight of the Sn-MWW.7. The process of claim 1 , wherein the Sn-MWW has a tin content in the range of from 0.1 to 1.0 weight-% or in the range of from 0.1 to 0.5 weight-% claim 1 , calculated as element and based on the weight of the Sn-MWW.8. The process of claim 1 , wherein at the beginning of the reaction according to (i) claim 1 , the molar ratio of Sn claim 1 , calculated as element and contained in the Sn-MWW claim 1 , relative to the compound according to formula (I) is in the range of from 0.001:1 to 0.05:1.9. The process of claim 1 , wherein at the beginning of ...

Подробнее
Номер записи: 42
22-02-2018 дата публикации

METHOD FOR PRODUCING (METH) ACRYLATE ESTER COMPOUNDS

Номер: US20180050975A1
Автор: KAJIYASHIKI Tsuyoshi, TAKAHATA Yusuke
Принадлежит: KURARAY CO., LTD.

An object of the invention is to provide a method for producing a (meth)acrylate ester compound by the transesterification of an alkyl (meth)acrylate with an alcohol compound having a tertiary hydroxyl group so as to esterify all the hydroxyl groups present in the alcohol compound with a high yield or, in a preferred embodiment, a method for esterifying a polyhydric alcohol compound having a tertiary hydroxyl group and also having a primary hydroxyl group and/or a secondary hydroxyl group by one-pot transesterification into a (meth)acrylate ester compound of the polyhydric alcohol. The method for producing a (meth)acrylate ester compound includes a step (I) of transesterifying an alkyl (meth)acrylate with an alcohol compound having a tertiary hydroxyl group using a transesterification catalyst including a complex of iron with a specific ligand, the water content in the transesterification reaction system being not more than 1000 ppm. 2. The production method according to claim 1 , wherein an amount of the transesterification catalyst in the transesterifying is from 0.1 to 20 mol % in terms of iron atoms relative to the hydroxyl groups of the alcohol compound.3. The production method according to claim 1 , wherein the alcohol compound is a polyhydric alcohol compound having a tertiary hydroxyl group and also having a primary hydroxyl group and/or a secondary hydroxyl group.5. The production method according to claim 3 , wherein the polyhydric alcohol compound is isoprene glycol.6. The production method according to claim 1 , wherein the alcohol compound having a tertiary hydroxyl group is a polyhydric alcohol compound having a primary hydroxyl group and/or a secondary hydroxyl group claim 1 , and the (meth)acrylate ester compound obtained is a polyvalent ester compound resulting from the esterification of all the hydroxyl groups present in the polyhydric alcohol compound.8. The production method according to claim 1 , wherein the (meth)acrylate ester compound is di( ...

Подробнее
Номер записи: 43
26-02-2015 дата публикации

Method for producing fatty acid ester

Номер: US20150056671A1
Автор: Hiroyuki Konishi, Saki Hamada, Takaaki Watanabe
Принадлежит: Kao Corp

Provided is a method of producing a fatty acid ester in a high yield through a simple operation using Euglena as a material. The method of producing a fatty acid ester comprises the following steps (a) and (b): (a) adding 0.001 to 9.5 [PU/g-dry cell] of at least one kind of protease to Euglena to react the Euglena and the protease in an aqueous phase; and (b) performing phase separation and collection of a fatty acid ester from a reaction liquid of the step (a).

Подробнее
Номер записи: 44
01-03-2018 дата публикации

AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS

Номер: US20180057444A1
Автор: GAO HONGYIN, Kürti László, ZHOU Zhe
Принадлежит: William Marsh Rice University

In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions. 1. A method of preparing an aminoaromatic group or a hydroxyaromatic group comprising:(A) admixing a metal aromatic compound with an oxaziridine compound to form a first reaction mixture under conditions sufficient to cause a reaction to obtain an anionic intermediate;(B) admixing a weak acid with the anionic intermediate and the first reaction mixture to obtain a second reaction mixture under conditions sufficient to obtain an aminoaromatic group or a hydroxyaromatic group.2. The method of claim 1 , wherein the metal of the metal aromatic compound is attached to one of the carbon atoms of the aromatic ring.3. The method of claim 1 , wherein the metal of the metal aromatic compound is a magnesium halide or lithium.48-. (canceled)9. The method of claim 1 , wherein the metal aromatic compound is substituted.10. (canceled)11. The method of claim 9 , wherein the metal aromatic compound is substituted with a substituent wherein the substituent is amino claim 9 , aminosulfonyl claim 9 , carboxy claim 9 , cyano claim 9 , halo claim 9 , hydroxy claim 9 , hydroxyamino claim 9 , hydroxysulfonyl claim 9 , mercapto claim 9 , nitro claim 9 , oxo claim 9 , or thio; or acyl claim 9 , alkoxy claim 9 , cycloalkoxy claim 9 , alkenyloxy claim 9 , aryloxy claim 9 , aralkoxy claim 9 , acyloxy claim 9 , cycloalkylalkoxy claim 9 , heterocycloalkylalkoxy claim 9 , heterocycloalkoxy claim 9 , alkylthio claim 9 , cycloalkylthio claim 9 , amido claim 9 , alkylamino claim 9 , dialkylamino claim 9 , alkylsulfonyl claim 9 , arylsulfonyl claim 9 , or a substituted version of these groups ...

Подробнее
Номер записи: 45
20-02-2020 дата публикации

PREPARATION OF COMPOUNDS FROM LEVULINIC ACID

Номер: US20200055816A1
Автор: Dutta Saikat, Mascal Mark, Wu Linglin
Принадлежит:

The present invention provides a method of making carboxylic acids from levulinic acid, such as succinic acid and 3-hydroxypropanoic acid, by reacting levulinic acid with an oxidant such as hydrogen peroxide under acidic or basic conditions. 1. A method of preparing a carboxylic acid , wherein the carboxylic acid is 3-hydroxypropanoic acid , comprising:forming a reaction mixture comprising levulinic acid, an oxidant, and a base, under conditions suitable to prepare the carboxylic acid.2. (canceled)3. The method of claim 1 , wherein the oxidant is hydrogen peroxide.4. The method of claim 3 , wherein the reaction mixture is substantially free of an oxidizing metal catalyst.512.-. (canceled)13. The method of claim 1 , wherein the base is selected from the group consisting of sodium hydroxide and potassium hydroxide.14. The method of claim 1 , wherein the reaction mixture is at a temperature between about 75° C. and about 200° C.15. The method of claim 1 , wherein the method comprises:forming the reaction mixture comprising levulinic acid, hydrogen peroxide, and potassium hydroxide, wherein the reaction mixture is at a temperature between about 100° C. and about 150° C., thereby forming the 3-hydroxypropanoic acid.16. The method of claim 1 , wherein the reaction mixture is at a temperature between about 0° C. and about 50° C. such that the product of the forming step is 3-(hydroperoxy)propanoic acid claim 1 , and the method further comprises:forming a second reaction mixture comprising the 3-(hydroperoxy)propanoic acid and a hydrogenation agent, under conditions suitable to form the 3-hydroxypropanoic acid.17. The method of claim 16 , wherein the hydrogenation agent is palladium on carbon.18. The method of claim 16 , wherein the method comprises:forming the reaction mixture comprising levulinic acid, hydrogen peroxide, and potassium hydroxide, wherein the reaction mixture is at about room temperature, thereby preparing 3-(hydroperoxy)propanoic acid; andforming the ...

Подробнее
Номер записи: 46
08-03-2018 дата публикации

METHOD FOR PRODUCING ORGANIC ACIDS AND ORGANIC ACID DEGRADATION COMPOUNDS FROM BIOMASS

Номер: US20180065898A1
Автор: Carroll Michael Eugene, Kelly John Patrick, Topping Paul
Принадлежит: Georgia-Pacific LLC

A method and integrated reactor system are provided for producing one or more organic acids, organic acid degradation compounds, and combinations thereof, from various types of biomass, including sludge from a pulp and paper mill. 1. A process for producing one or more organic acids , comprising:at least partially hydrolyzing a lignocellulosic biomass comprising a six carbon chain sugar precursor to produce an at least partially hydrolyzed lignocellulosic biomass comprising a six carbon chain sugar;heating the at least partially hydrolyzed lignocellulosic biomass comprising the six carbon chain sugar to a temperature of about 150° C. to about 250° C. to convert the six carbon chain sugar to a first product comprising a first organic acid; andheating a sludge from a pulp and paper mill comprising an additional six carbon chain sugar to convert the additional six carbon chain sugar to a second product comprising a second organic acid.2. The process of claim 1 , further comprising mixing the first product and the second product to produce a combined product comprising the first organic acid and the second organic acid.3. The process of claim 1 , wherein the first organic acid comprises levulinic acid claim 1 , formic acid claim 1 , acetic acid claim 1 , propionic acid claim 1 , or a mixture thereof claim 1 , and wherein the second organic acid comprises levulinic acid claim 1 , formic acid claim 1 , acetic acid claim 1 , propionic acid claim 1 , or a mixture thereof.4. The process of claim 1 , wherein the lignocellulosic biomass is contacted with steam claim 1 , a mineral acid claim 1 , an alcohol claim 1 , or a mixture thereof to produce the at least partially hydrolyzed lignocellulosic biomass.5. The process of claim 4 , wherein the lignocellulosic biomass is contacted with the mineral acid claim 4 , and wherein the mineral acid is present in an amount of up to 10% by weight of the lignocellulosic biomass.6. The process of claim 1 , wherein the lignocellulosic ...

Подробнее
Номер записи: 47
08-03-2018 дата публикации

ORGANIC COMPOUNDS

Номер: US20180066003A1
Автор: GEISSER Roger Wilhelm, OETIKER Jurg Daniel, Schröder Fridtjof
Принадлежит:

A process for the hydrogenation of a substrate comprising a carbon heteroatom double bond in the presence of a transition metal complex comprising a tridentate or bisdentate-ligand containing a nitrogen, sulphur and phosphorus atom, of which at least the N- and P- and optionally also the S-atom coordinates with the transition metal. 2. A process according to claim 1 , wherein the nitrogen atom on the tridentate or bisdentate ligand forms part of an amine group or an imine group; the sulphur atom forms part of an aliphatic group or forms part of an aromatic ring; and the phosphorus atom forms part of a phosphine group.3. A process according to or wherein the nitrogen atom-containing group is flanked on one side by the phosphorus atom-containing group claim 1 , and on the other side by the sulphur atom-containing group.6. A process according to any of the preceding claims wherein the metal M is ruthenium or osmium.7. A process according to any of the preceding claims wherein the functional group that is hydrogenated is selected from the group consisting of an ester claim 1 , lactone claim 1 , ketone claim 1 , aldehyde claim 1 , amide claim 1 , lactam and imine.8. A process according to any of the preceding claims wherein the substrate bearing a functional group containing a carbon heteroatom double bond is sclareolide and the hydrogenated product is sclareodiol.11. A complex according to wherein the nitrogen atom on the tridentate or bisdentate ligand forms part of an amine group or an imine group; the sulphur atom forms part of an aliphatic group or forms part of an aromatic ring; and the phosphorus atom forms part of a phosphine group.12. A complex according to or claim 10 , wherein the nitrogen atom-containing group is flanked on one side by the phosphorus atom-containing group claim 10 , and on the other side by the sulphur atom-containing group.15. A complex according to any of the through wherein the metal M is ruthenium or osmium. The present invention relates ...

Подробнее
Номер записи: 48
08-03-2018 дата публикации

A NOVEL CHIRAL POLYMER FOR ENANTIOSELECTIVE SEPARATION AND PROCESS FOR PREPARATION THEREOF

Номер: US20180066102A1
Автор: Asha Shyama Kumari, Senthilkumar Thangaraj
Принадлежит:

The present invention relates to a novel polyfluorene appended with protected glutamic acid of Formula (I) for heterogeneous enantioselective separation and sensing of amino acids, amino alcohol, hydroxyl acid, sugar, aromatic drug and ascorbic acid from racemic mixture in water and process for preparation thereof. The present invention further provides a process for separation of enantiomers and diastereomers into their individual isomers using a polyfluorene compounds of Formula (I). 2. The polymer as claimed in claim 1 , wherein R is glutamic acid.3. The polymer as claimed in claim 1 , wherein said polymer is polyfluorene appended with dicarboxylic amino acid for heterogeneous enantioselective separation and sensing of amino acids claim 1 , amino alcohol claim 1 , hydroxyl acid claim 1 , sugar claim 1 , aromatic drugs and ascorbic acid from racemic mixture in water.4. The polymer as claimed in claim 1 , wherein said polymer transforms from a helix form to β-sheet in water.5. A process of preparation of polymer of Formula I comprising the steps of:a) preparing a reaction mixture of 2,7-dibromofluorene, 6-bromohexan-1-ol and tetrabutyl ammonium chloride in toluene or DMSO.b) adding sodium hydroxide to the reaction mixture of step (a) followed by heating the mixture at the temperature ranging from 120° C. to 130° C. under argon atmosphere for 12 to 20 h to afford 2,7-dibromo-9,9-di-n-hexanolfluorene;c) esterifying 2,7-dibromo-9,9-di-n-hexanolfluorene using 4-dimethyl amino pyridine and boc-L-glutamic acid-1-tert butyl ester in presence of dicyclohexylcarbodiimide to afford (S)-1-tert-butyl-5-(6-(2,7-dibromo-9-(6-(((R)-5-(tert-butoxy)-4-((tert-butoxycarbonyl)amino)-5- oxopentanoyl)oxy)hexyl)-9H-fluoren-9-yl)hexyl)2-((tert-butoxycarbonyl)amino)pentanedioate;{'sub': 3', '4, 'd) adding potassium carbonate to the reaction mixture comprising product of step (c), 1,4-benzene diboronic ester and Pd(PPh)in THF followed by refluxing at a temperature ranging from 65° C. to 70° ...

Подробнее
Номер записи: 49
19-03-2015 дата публикации

METHOD FOR PRODUCING ORGANIC ACIDS AND ORGANIC ACID DEGRADATION COMPOUNDS FROM BIOMASS

Номер: US20150080603A1
Автор: Carroll Michael Eugene, Kelly John Patrick, Topping Paul
Принадлежит: Georgia-Pacific LLC

A method and integrated reactor system are provided for producing one or more organic acids, organic acid degradation compounds, and combinations thereof, from various types of biomass, including sludge from a pulp and paper mill. 1. A method for producing one or more organic acids , organic acid degradation products , and combinations thereof , comprising the steps of:providing a biomass feed comprising a sludge from a pulp and paper mill including one or more six carbon chain sugars, a lignocellulosic biomass, or a combination thereof; andhydrolyzing the biomass feed in one or more reactors to one or more organic acids, organic acid degradation products, or combinations thereof2. The method of claim 1 , wherein the biomass feed comprises sludge and lignocellulosic biomass.3. The method of claim 2 , wherein the sludge and lignocellulosic biomass are mixed prior to being added to the reactor.4. The method of claim 2 , wherein the sludge and lignocellulosic biomass are added separately to the reactor.5. The method of claim 1 , wherein the step of hydrolyzing the biomass feed comprises partially hydrolyzing the biomass feed to form one or more six carbon chain sugars claim 1 , and converting the one or more six carbon chain sugars to one or more organic acids claim 1 , organic acid degradation compounds claim 1 , or combinations thereof6. The method of claim 5 , wherein the step of partially hydrolyzing the biomass feed comprises contacting the biomass feed with one or more of steam claim 5 , at least one acid claim 5 , or at least one alcohol.7. The method of claim 5 , wherein the step of partially hydrolyzing the biomass feed is carried out in a first reactor at a temperature of about 170° C. to about 185° C. for about 35 minutes to about 60 minutes.8. The method of claim 7 , wherein the first reactor comprises a tubular reactor with axial mixing.9. The method of claim 5 , wherein the step of converting the one or more six carbon chain sugars is carried out in a ...

Подробнее
Номер записи: 50
22-03-2018 дата публикации

METHOD FOR PRODUCING ALKYLAMINE DERIVATIVE AND ITS PRODUCTION INTERMEDIATE OF ALKYLAMINE DERIVATIVE

Номер: US20180079715A1
Автор: ABE Nobuteru, KOBAYASHI Yasuhisa, MATSUZAWA Toshihiro, Muronoi Shin, Niwa Seiji, OKADO Kotaro
Принадлежит: AJINOMOTO CO., INC.

A method for producing an alkylamine derivative having a urea bond represented by formula (I), or a salt thereof, comprises the following steps (a) and (b), step (a): 2. The production method according to claim 1 , wherein in formula (II) claim 1 , R1represents a benzyloxycarbonyl group or a t-butoxycarbonyl group.3. The production method according to claim 1 , wherein in formula (III) claim 1 , R3 and R4 each independently represent a hydrogen atom claim 1 , an unsubstituted Calkyl group claim 1 , a halogen atom claim 1 , or a hydroxy group.4. The production method according to claim 1 , wherein the carbonyl group-introducing reagent is a chloroformic ester claim 1 , carbonyldiimidazole claim 1 , phosgene claim 1 , triphosgene claim 1 , or dimethyl carbonate.5. The production method according to claim 1 , wherein in step (a) claim 1 , the carbonyl group-introducing reagent is carbonyldiimidazole claim 1 , the base is absent claim 1 , and the solvent is one or two or more solvents selected from acetone claim 1 , methyl ethyl ketone claim 1 , methyl isobutyl ketone claim 1 , dichloromethane claim 1 , tetrahydrofuran and acetonitrile.6. The production method according to claim 1 , wherein in step (a) claim 1 , the carbonyl group-introducing reagent is a chloroformic ester claim 1 , the base is one or two or more bases selected from triethylamine claim 1 , pyridine claim 1 , and diisopropylethylamine claim 1 , and the solvent is one or two or more solvents selected from acetonitrile claim 1 , propionitrile claim 1 , dichloromethane claim 1 , acetone claim 1 , N claim 1 ,N-dimethylformamide and tetrahydrofuran.7. The production method according to claim 6 , wherein the chloroformic ester is methyl chloroformate claim 6 , ethyl chloroformate claim 6 , phenyl chloroformate claim 6 , 4-chlorophenyl chloroformate or 4-nitrophenyl chloroformate.9. The production method according to claim 1 , wherein R1represents a tert-butoxycarbonyl group claim 1 , and in step (b) claim 1 , ...

Подробнее
Номер записи: 51
30-03-2017 дата публикации

Hydroformylation catalyst

Номер: US20170087542A1
Автор: Brian E. Green, Jody Lee Rodgers, Thomas Allen Puckette, Xiaopeng Shan
Принадлежит: Eastman Chemical Co

This invention pertains to hydroformylation catalysts containing a mixture of isomeric forms of halo-phosphorus ligands. This invention also describes a procedure for preparing isomers of certain halophosphite ligands, which contain the phosphorus atom in a macrocyclic ring.

Подробнее
Номер записи: 52
19-03-2020 дата публикации

METHOD FOR PRODUCING GLYCERIC ACID ESTER

Номер: US20200087290A1
Автор: AOKI Takashi
Принадлежит: KAO CORPORATION

The present invention relates to providing a novel glyceric acid ester which can be produced in a high yield and is expected to be applied as a synthetic intermediate, and a method of producing the same. In addition, the present invention relates to providing a novel glyceric acid ester which exhibits a high recovery in a water-washing step after the reaction and a small work load at the time of production, and is expected to be applied as a synthetic intermediate, and a method of producing the same. The present invention provides a method of producing a compound represented by the following formula (II), including a step of oxidatively esterifying a compound represented by the following formula (I): 3. The production method according to claim 1 , wherein in the step of performing oxidative esterification claim 1 , a compound selected from an organic nitroxyl radical claim 1 , an N-hydroxy form thereof claim 1 , and a salt containing an oxo ammonium cation of them claim 1 , an oxidizing agent claim 1 , and a base are used.4. The production method according to claim 3 , wherein the base is a heterocyclic aromatic amine having a pyridine skeleton.6. The production method according to claim 3 , wherein the oxidizing agent is an oxidizing agent composed of a compound containing a halogen.7. The production method according to claim 1 , comprising claim 1 , after the step of performing oxidative esterification claim 1 , a step of separating the compound represented by the formula (II).8. The production method according to claim 7 , wherein the separation in the step of separating the compound represented by the formula (II) is separation through distillation.9. A method of producing glyceric acid claim 1 , a glyceric acid salt claim 1 , or a deprotected glyceric acid ester claim 1 , comprising a step of producing the compound represented by the formula (II) by the production method according to claim 1 , and a step of subjecting the compound represented by the formula (II ...

Подробнее
Номер записи: 53
02-06-2022 дата публикации

Monocarbonyl ruthenium and osmium catalysts

Номер: US20220168720A1
Автор: Salvatore Baldino, Steven GIBOULOT, Walter Baratta
Принадлежит: Innovation Factory SRL, UNIVERSITÀ DEGLI STUDI DI UDINE

The invention relates to monocarbonyl complexes of ruthenium and osmium with bi- and tridentate nitrogen and phosphine ligands. The invention relates to methods for preparing these complexes and the use of these complexes, isolated or prepared in situ, as catalysts for reduction reactions of ketones and aldehydes both via transfer hydrogenation or hydrogenation with hydrogen.

Подробнее
Номер записи: 54
19-04-2018 дата публикации

Process for producing esterified cellulose ethers of very high molecular weight and low viscosity

Номер: US20180105608A1
Автор: Oliver Petermann
Принадлежит: Dow Global Technologies LLC

A modified process for producing an esterified cellulose ether is provided which comprises the stages of i) preparing a reaction mixture comprising a cellulose ether, an aliphatic monocarboxylic acid anhydride, a dicarboxylic acid anhydride, and a reaction diluent and heating the reaction mixture to a temperature of from 60° C. to 110° C. prior to, during or after mixing the components of the reaction mixture to conduct an esterification reaction, and ii) before the esterification reaction is completed, adding an additional amount of reaction diluent continuously or in one or more portions to the reaction mixture and allowing the esterification reaction to further proceed.

Подробнее
Номер записи: 55
20-04-2017 дата публикации

NOVEL RUTHENIUM COMPLEXES AND THEIR USES IN PROCESSES FOR FORMATION AND/OR HYDROGENATION OF ESTERS, AMIDES AND DERIVATIVES THEREOF

Номер: US20170107251A1
Автор: Balaraman Ekambaram, Gnanaprakasam Boopathy, Gunanathan Chidambaram, Milstein David, Zhang Jing
Принадлежит:

The present invention relates to novel Ruthenium complexes and related borohydride complexes, and their use for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including preparing polyamides (e.g., polypeptides) by reacting dialcohols and diamines or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones), cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to novel uses of certain pyridine Ruthenium complexes. 4. The process according to claim 1 , wherein Xand/or Xare absent claim 1 , and the pyridyl or bipyridy moiety is unsubstituted.5. The process according to claim 1 , wherein Lis phosphine (PRR).13. The process according to claim 10 , wherein Xand/or Xare absent claim 10 , and the pyridyl or bipyridy moiety is unsubstituted.14. The process according to claim 10 , wherein Lis phosphine (PRR).16. The process of claim 10 , for preparing an amide from amine and an alcohol claim 10 , wherein the process is for preparing a polypeptide or a cyclic dipeptide claim 10 , and wherein the primary or secondary amine and the primary alcohol are a beta-aminoalcohol. This application is a Divisional Application from U.S. application Ser. No. 14/702,641 filed May 1, 2015, which is a Divisional Application from U.S. application Ser. No. 13/880,328 filed Jun. 11, 2013 now U.S. Pat. No. 9,045,381, ...

Подробнее
Номер записи: 56
28-04-2016 дата публикации

Treatment of Carbonaceous Feedstocks

Номер: US20160115091A1
Автор: Bartek Robert, Rejai Bahman
Принадлежит: CIRIS ENERGY, INC.

A method for treatment of a carbonaceous feedstock such as coal or black liquor is disclosed. The method comprises heating a mixture of the carbonaceous feedstock, with or without a solubilizing agent, water, and an oxidizing agent to solubilize and oxidize carbonaceous materials. In case of oxidation of black liquor, at least one organic compound comprising from about 2 to about 20 carbon atoms may be obtained. The reaction products may be chemically or physically separated, recycled to the heating step and/or subjected to microbial digestion in order to generate one or more desirable products from the carbonaceous feedstock. 1. A method for treating a carbonaceous feedstock , comprising the step of heating a mixture of a carbonaceous feedstock with water in the presence of at least one oxidizing agent to a temperature below 300° C. and a pressure below 1230 psig.2. The method of claim 1 , wherein the mixture comprises at least one solubilizing agent selected from the group consisting of mineral acids or mineral bases.3. The method of claim 1 , wherein the heating step is configured as multiple heating steps and each heating step has at least one different condition selected from the group consisting of temperature claim 1 , pressure claim 1 , and duration.46-. (canceled)7. The method of claim 2 , wherein the mixture comprises at least one catalyst.8. The method of claim 7 , wherein the at least one catalyst is selected from the group consisting of non-soluble metals claim 7 , transition metals and precious metals.9. The method of claim 8 , wherein the at least one catalyst is supported on a matrix material selected from the group consisting of clay claim 8 , alumina claim 8 , silica claim 8 , silica alumina claim 8 , zeolites claim 8 , activated carbon claim 8 , diatomaceous earth claim 8 , titania claim 8 , zirconia claim 8 , molybdena claim 8 , and ceramics.1013-. (canceled)14. The method of claim 1 , wherein the at least one oxidizing agent is selected from the ...

Подробнее
Номер записи: 57
26-04-2018 дата публикации

METHOD FOR MAKING METHIONINE

Номер: US20180111899A1
Автор: Capelle Nicolas, REY Patrick
Принадлежит:

The invention concerns a continuous process for manufacturing methionine by alkaline hydrolysis of methionine hydantoin in aqueous phase, removing NHand COof the hydrolysis medium, and neutralizing the obtained methioninate salt, according to which, after removal of NHand CO, the hydrolysis reaction medium is concentrated to precipitate NaCO, said NaCObeing separated then recycled for alkaline hydrolysis, the latter being carried out in the presence of NaOH and NaCO. 1. A continuous process for manufacturing methionine by alkaline hydrolysis of methionine hydantoin in aqueous phase , comprising removing NHand COfrom the hydrolysis medium , neutralizing the obtained methioninate salt , and after removing NHand CO , the hydrolysis reaction medium is concentrated to precipitate NaCO , said NaCObeing separated then recycled for alkaline hydrolysis , the latter being carried out in the presence of NaOH and NaCO.2. The process according to claim 1 , wherein the hydrolysis reaction medium contains the methioninate salt and the concentration is carried out by removing water from the medium up to a concentration of the methioninate salt ranging from 20 to 70% claim 1 , by mass of sodium methioninate with respect to the mass of the medium.3. The process according to claim 2 , wherein the water removal is performed by evaporation at a temperature ranging from 90 to 110° C. claim 2 , under atmospheric pressure.4. The process according to claim 2 , wherein the water removal is performed by vacuum evaporation at a temperature ranging from 30 to 90° C.5. The process according to claim 1 , wherein NaCOis separated by filtration at a temperature ranging from 70 to 130° C.6. The process according to claim 1 , wherein after separation claim 1 , NaCOis dissolved in the evaporated water then recycled to the hydrolysis of methionine hydantoin.7. The process according to claim 1 , wherein the molar ratio Na/S for alkaline hydrolysis of methionine hydantoin is at least 2.0.8. The process ...

Подробнее
Номер записи: 58
26-04-2018 дата публикации

PREPARATION OF PANTOLACTONE

Номер: US20180111911A1
Автор: DESCHLER Jürgen, DOBLER walter, Fischer Klaus, Lauterbach Arnulf, Nehls Benjamin, SCHLAUTMANN Sabine
Принадлежит:

The present invention relates to a novel process for the preparation of pantolactone by reaction of hydroxypivalaldehyde cyanohydrin in a phase separation process. 118.-. (canceled)2017. The process according to claim , where , for the provision of the starting material in step a):a1) formaldehyde is subjected with isobutyraldehyde to an aldol addition, giving hydroxypivalaldehyde, anda2) the hydroxypivalaldehyde is reacted with a cyanide source, giving hydroxypivalaldehyde cyanohydrin (II).21. The process according to claim 19 , where the acid used in step b) is at least 90% strength HSO.22. The process according to claim 19 , where claim 19 , during the reaction in step b) claim 19 , the pH of the reaction mixture is kept in a range from 0 to 1.2.23. The process according to claim 19 , where claim 19 , in step b) claim 19 , the molar ratio of the acid used to hydroxypivalaldehyde cyanohydrin (II) is in a range from 0.5:1 to 2:1.24. The process according to claim 19 , where the reaction in step b) takes place at a temperature from 50 to 110° C.25. The process according to claim 19 , where the reaction in step b) takes place at a pressure in the range from 850 to 1150 mbar.26. The process according to claim 19 , where the reaction in step b) takes place at a pressure in the range from 100 to 800 mbar.27. The process according to claim 26 , where claim 26 , during the reaction in step b) claim 26 , water is removed distillatively from the reaction mixture.28. The process according to claim 19 , where claim 19 , in step c) claim 19 , at least one base is added to the reaction product from step b) until the pH is in a range from 4 to 6.29. The process according to claim 19 , where the reaction in step b) takes place at a pressure in the range from 200 to 700 mbar claim 19 , and during the reaction in step b) water is removed distillatively from the reaction mixture and claim 19 , in step c) claim 19 , aqueous NHis added as base to the reaction product from step b).30. ...

Подробнее
Номер записи: 59
13-05-2021 дата публикации

ETHYLENE-TO-LIQUIDS SYSTEMS AND METHODS

Номер: US20210139391A1
Автор: Abudawoud Raed Hasan, Black Richard, Crisci Anthony, Czerpak Peter, GRAUER David C., Michalak William, Nyce Greg, Patel Bipinkumar, Radaelli Guido, Rappold Tim A., Zhang Aihua
Принадлежит:

The present disclosure provides petrochemical processing methods and systems, including ethylene conversion processes and systems, for the production of higher hydrocarbon compositions, for example liquid hydrocarbon compounds, with reduced amount of unsaturated hydrocarbons. 1. A method for generating hydrocarbon compounds with eight or more carbon atoms (C compounds) , comprising:{'sub': 2+', '2+', '3+, '(a) directing a feed stream comprising unsaturated C hydrocarbon compounds into an oligomerization unit that permits at least a portion of said unsaturated C hydrocarbon compounds to react in an oligomerization process to yield an effluent comprising unsaturated C hydrocarbon compounds; and'}{'sub': 3+', '8+, '(b) directing at least a portion of said effluent from said oligomerization unit and a stream comprising isoparaffins into an alkylation unit downstream of and separate from said oligomerization unit, which alkylation unit permits at least a portion of said unsaturated C hydrocarbon compounds and said isoparaffins to react in an alkylation process to yield a product stream comprising said C compounds.'}2. The method of claim 1 , further comprising: directing methane and an oxidizing agent into an oxidative coupling of methane (OCM) unit that facilitates an OCM reaction to generate an OCM product stream comprising ethylene (CH) claim 1 , and wherein at least a portion of said feed stream is provided by the OCM product stream.3. The method of claim 1 , wherein the oligomerization unit comprises a dimerization unit and the oligomerization process comprises a dimerization process claim 1 , and wherein the dimerization process operates at a temperature of 20° C. to 200° C. and a pressure of 100 psia to 400 psia.4. The method of claim 1 , wherein the product stream is an alkylate stream comprising an alkylate product comprising saturated C hydrocarbon compounds claim 1 , isomers thereof claim 1 , or both saturated C hydrocarbon compounds and isomers thereof.5. The ...

Подробнее
Номер записи: 60
12-05-2016 дата публикации

PRODUCTION METHOD FOR OPTICALLY ACTIVE ALCOHOL COMPOUND

Номер: US20160130193A1
Автор: Kawanami Hirotaka, Murase Shota, NISHINO Yukihiro
Принадлежит: NISSAN CHEMICAL INDUSTRIES, LTD.

A method for stereoselectively producing an optically active alcohol compound. The optically active alcohol compound of Formula (8) can be produced in high yield and high selectivity from the compound of Formula (3), and the production method that is useful industrially and the intermediates therefor can be provided. In formulae, Ris a hydrogen atom, Calkyl, Calkyl optionally substituted with R, or the like, Ris cyano or —CHN(R)R, and Ris Ccycloalkyl. 2. The method for producing the optically active alcohol compound according to claim 1 , wherein Ris a hydrogen atom claim 1 , (C) alkyl optionally substituted with R claim 1 , —C(O)R— claim 1 , or —Si(R)(R)R.3. The method for producing the optically active alcohol compound according to claim 2 , wherein the reaction is carried out in the presence of the optically active ruthenium catalyst of Formula (4).4. The method for producing the optically active alcohol compound according to claim 3 , wherein{'sup': 2', '5', '4, 'sub': '2', 'Ris —CHN(R)R;'}{'sup': 4', '6', '7, 'Ris —C(O)Ror —C(O)OR;'}{'sup': '6', 'sub': 1-6', '1-6, 'Ris Calkyl or (C) alkyl optionally substituted with a halogen atom; and'}{'sup': '8', 'sub': 1-6', '1-6, 'Ris a hydrogen atom, Calkyl, or (C) alkyl optionally substituted with a halogen atom.'}5. The method for producing the optically active alcohol compound according to claim 4 , wherein{'sup': 1', '3', '12a', '12b', '12, 'sub': '1-6', 'Ris (C) alkyl optionally substituted with R, or —Si(R)(R)R;'}{'sup': '3', 'sub': '3-8', 'Ris phenyl, or Ccycloalkyl;'}{'sup': 5', '5', '4', '5', '4, 'sub': '4', 'Ris a hydrogen atom, or Roptionally forms a 5-membered ring together with a nitrogen atom to which Rand Rare bonded by forming a Calkylene chain together with R, and in this case the alkylene chain is optionally substituted with an oxo group, or the alkylene chain optionally forms phenyl together with carbon atoms to which two substituents each bond when the two substituents exist at adjacent positions on ...

Подробнее
Номер записи: 61
10-05-2018 дата публикации

LIQUID THIOETHER CARBOXYLIC ACID ESTERS

Номер: US20180127363A1
Автор: CASPARI Philip, Dietliker Kurt, KUKALEVA Natalia, NIEDERER David, OEHRLEIN Reinhold
Принадлежит: BASF SE

The present invention relates to a liquid thioether carboxylic acid ester, a process for the preparation of the liquid thioether carboxylic acid ester, an article comprising the liquid thioether carboxylic acid ester as well as a use of the liquid thioether carboxylic acid ester as a component or substantial part of an optical system, tunable lens, adaptive optical module and materials thereof, actuator, electro-active polymer, laser and all related products, optical liquid, cover glass, lens or container material, tiltable prism or optical calibration liquid or optical refractive index matching liquid and a use of the liquid thioether carboxylic acid ester as a component or substantial part of a color filter, window material, coating, varnish, lacquer, dye or pigment formulation, immersion liquid, ingredient or additive in a plastic material or ingredient or additive in a polymer. 2. The liquid thioether carboxylic acid ester according to claim 1 , wherein in the formula (A1) Ris hydrogen or ethyl; Ris hydrogen or a linear C-C-alkyl containing at least one sulfhydryl moiety (SH); Rand Rare independently selected from a linear C-C-alkyl containing at least one sulfhydryl moiety (SH) claim 1 , and one or two CHgroup(s) of Rand/or Rand/or Ris/are replaced by O claim 1 , S and/or C═O.3. The liquid thioether carboxylic acid ester according to claim 1 , wherein in the formula (A1) Ris hydrogen; Ris a linear C-C-alkyl containing at least one sulfhydryl moiety (SH); Rand Rare independently selected from a linear C-C-alkyl containing at least one sulfhydryl moiety (SH) claim 1 , and one CHgroup of Rand/or Rand Ris replaced by S.4. The liquid thioether carboxylic acid ester according to claim 1 , wherein in the formula (A1) Ris hydrogen or ethyl; Ris hydrogen or a linear C-C-alkyl containing at least one sulfhydryl moiety (SH); Rand Rare independently selected from a linear C-C-alkyl containing at least one sulfhydryl moiety (SH) claim 1 , and two CHgroups of Rand/or Rand ...

Подробнее
Номер записи: 62
10-05-2018 дата публикации

Method for producing aqueous hydrolysates from aminoalkyltrialkoxysilanes

Номер: US20180127442A1
Автор: Burkhard Standke, Christian Wassmer, Irene Lippert, Kerstin Bibbo
Принадлежит: EVONIK DEGUSSA GmbH

The present invention relates to a process for preparing aqueous hydrolysates of aminoalkyltrialkoxysilanes by (a) initially charging water, optionally heating, (b) adding hydrolysable silanes consisting of at least one aminoalkyltrialkoxysilane in an amount which provides a molar ratio of water to total amount of aminoalkyltrialkoxysilane of 10.5 to 20, and (c) distilling off the alkyl alcohol formed in the reaction, wherein the solids content in an aqueous composition thus prepared is 30% to 55% by weight, based on the composition, and the aqueous solution has a total content of free and bound alkyl alcohol of not more than 1% by weight, based on the composition.

Подробнее
Номер записи: 63
11-05-2017 дата публикации

CONVERSION OF GREENHOUSE GASES BY DRY REFORMING

Номер: US20170129777A1
Автор: King Paul E., Livneh Ben Zion
Принадлежит:

A method for conversion of greenhouse gases comprises: introducing a flow of a dehumidified gaseous source of carbon dioxide into a reaction vessel; introducing a flow of a dehumidified gaseous source of methane into the reaction vessel; and irradiating catalytic material in the reaction vessel with microwave energy. The irradiated catalytic material is heated and catalyzes an endothermic reaction of carbon dioxide and methane that produces hydrogen and carbon monoxide. At least a portion of heat required to maintain a temperature within the reaction vessel is supplied by the microwave energy. A mixture that includes carbon monoxide and hydrogen can undergo catalyzed reactions producing multiple-carbon reaction products in a lower-temperature portion of the reaction vessel. 1. A method for simultaneously consuming carbon dioxide and generating one or more multiple-carbon reaction products in a single reaction vessel , the method comprising:(a) introducing a flow of a dehumidified gaseous source of carbon dioxide into a higher-temperature portion of a reaction vessel;(b) introducing a flow of a dehumidified gaseous source of methane into the higher-temperature portion of the reaction vessel;(c) irradiating first catalytic material in the higher-temperature portion of the reaction vessel with microwave energy so as to heat the first catalytic material and drive an endothermic reaction of the carbon dioxide and the methane, catalyzed by the first catalytic material, that produces hydrogen and carbon monoxide;(d) cooling a lower-temperature portion of the reaction vessel, thereby establishing a temperature gradient within the reaction vessel wherein the irradiated, higher-temperature portion of the reaction vessel exhibits a higher temperature than the cooled, lower-temperature portion of the reaction vessel, wherein at least a portion of heat required to maintain the temperature gradient is supplied by the microwave energy irradiating the first catalytic material in ...

Подробнее
Номер записи: 64
26-05-2016 дата публикации

REACTIVE CHROMATOGRAPHY PROCESS FOR EQUILIBRIUM-LIMITED REACTIONS

Номер: US20160145167A1
Автор: DONALDSON Megan E., Frank Timothy C.
Принадлежит: Dow Global Technologies, LLC

The present disclosure provides for a process for an equilibrium limited reaction using reactive chromatography unit (RCU) in which a first organic donor reactant (FODR) and a second organic acceptor reactant (SOAR) react to form a product mixture of a first acceptor product (FAP) and a second donor co-product (SDCP). The equilibrium-limited reaction does not produce water. The RCU has separation media to separate the product mixture into a raffmate and an extract. The FODR is in a stoichiometric deficit relative to the SOAR for the equilibrium limited reaction, so that the SOAR acts as the eluent for both the raffmate and the extract, and so as not to produce an azeotrope of FODR and the SDCP in the extract.

Подробнее
Номер записи: 65
26-05-2016 дата публикации

2-oxo-1,3-dioxolane-4-acyl halides, their preparation and use

Номер: US20160145232A1
Автор: Burkhard Walther, Heimo WÖLFLE, Maximilian Kohler, Sophie PUTZIEN
Принадлежит: CONSTRUCTION RESEARCH AND TECHNOLOGY GmbH

The present invention suggests 2-oxo-1,3-dioxolane-4-acyl halides of formula (I), wherein X is selected from F, Cl, Br, I and mixtures thereof, preferably Cl, processes for the preparation of said 2-oxo-1,3-dioxolane-4-acyl halides, the use of said 2-oxo-1,3-dioxolane-4-acyl halides for the preparation of 2-oxo-1,3-dioxolane-4-carboxylic esters of formula (II), the use of said 2-oxo-1,3-dioxolane-4-acyl halides for the preparation of 2-oxo-1,3-dioxolane-4-carboxamides of formula (III), and also the use of said 2-oxo-1,3-dioxolane-4-acyl halides as agents for the blocking of amines.

Подробнее
Номер записи: 66
24-05-2018 дата публикации

METHOD FOR PREPARING IMIDAZOLE DERIVATIVE AND INTERMEDIATE THEREOF AND CRYSTAL FORM

Номер: US20180141915A1
Автор: He Haiying, Jiang Zhigan, LAI Kunmin, LI Hongwei, Li Weidong, Shi Weihua, Wang Zheng, WU Linghui, Xu Feng, Zeng Minggao
Принадлежит: Shandong Danhong Pharmaceutical Co., Ltd.

Disclosed are a method for preparing an imidazole derivative and crystal form A and crystal form B thereof, and also disclosed is a method for preparing a compound of formula (I) and an intermediate thereof. 4. The process according to claim 2 , wherein the acid is selected from the group consisting of trifluoroacetic acid claim 2 , acetic acid claim 2 , hydrochloric acid claim 2 , dilute sulfuric acid and p-toluenesulfonic acid.6. The process according to claim 5 , wherein the insert solvent is a single solvent or a mixed solvent for several solvents selected from the group consisting of ethyl acetate claim 5 , isopropyl acetate claim 5 , methyl tent-butyl ether claim 5 , cyclohexane and n-heptane.7. The process according to claim 6 , wherein the insert solvent is a mixed solvent of ethyl acetate and n-heptane.10. Crystal form A or Crystal form B of the compound of formula (I) claim 6 , the XRPD spectrogram is shown in and claim 6 , respectively.11. A process for preparing crystal form A according to claim 10 , comprising adding the compound of formula (I) to an organic solvent claim 10 , heating to 30° C. to the reflux temperature to dissolve claim 10 , and then cooling to 0 to 20° C. within 0.5 to 10 hours to precipitate the crystal.12. The process for preparing crystal form A according to claim 11 , wherein the organic solvent is selected from the group consisting of dichloroethane claim 11 , a Calkyl alcohol claim 11 , a Cether or cyclic ether claim 11 , a Cketone claim 11 , a Cester claim 11 , benzene optionally substituted by methyl or ethyl or halogen atom(s) claim 11 , wherein the number of the substituent(s) is selected from 1 claim 11 , 2 and/or 3.13. The process for preparing crystal form A according to claim 12 , the organic solvent is selected from the group consisting of dichloromethane claim 12 , methanol claim 12 , ethanol claim 12 , isopropanol claim 12 , tetrahydrofuran claim 12 , dioxane claim 12 , 2-methyltetrahydrofuran claim 12 , acetone claim ...

Подробнее
Номер записи: 67
24-05-2018 дата публикации

SALT FORM AND CRYSTAL FORM OF 1,2,5-THIADIAZOLIDIN-1,1-DIOXIDE, PREPARATION METHOD THEREOF AND INTERMEDIATE

Номер: US20180141940A1
Автор: CHEN Shuhui, Hao Fei, He Haiying, Li Peng, Li Zongbin, SHEN Wang, Wang Zheng, Wang Zhenzhong, Xiao Wei, YANG Bailing
Принадлежит:

The present invention discloses a salt form, crystal form and intermediate of the compound 1, and preparation method thereof. 910-. (canceled) The present invention relates to a salt form, crystal form and intermediate of the compound 1 and preparation method thereof.The enterovirus 71 is a member of small RNA virus family and one of the most common etiologies of hand-foot-mouth disease. It can also cause various diseases related to nervous system such as herpes pharyngitis, aseptic meningitis, encephalitis, and poliomyelitis-like paralysis and is possibly accompanied with severe central nervous system complications or neuritic pulmonary edema.The hand-foot-mouth disease has the features of strong epidemic intensity, strong infectivity, and complex transmission route. There is no specific anti-enterovirus 71 medicine yet.Although the existing technologies such as the patents of US20030087936, U.S. Pat. No. 6,706,739, US20040116476, US20050267164, and US20070049623 have disclosed a series of structures, for example the structures represented by Formula (B-I), it is still needed in urgency to develop a novel compound with better activity which is more beneficial to make medicine.The present invention provides a preparation method of compound 1,comprising the following steps:wherein, molar ratio of the compound 3-2 and the NaNOis 1:12; reaction solvent used in preparation of the compound 3-3 from the compound 3-2 is selected from methanol/water, ethanol/water, isopropanol/water or acetic acid/water; volume ratio of the water and the methanol, the ethanol, the isopropanol or the acetic acid is 1:13; weight ratio of the compound 3-2 and HO is 1:13.In some solutions according to the present invention, the above preparation method comprises the following steps:wherein, reaction solvent used in preparation of the compound 3-2 from the compound 3-1 is selected from methanol/dioxane, ethanol/dioxane, isopropanol/dioxane; volume ratio of the dioxane and the methanol, the ...

Подробнее
Номер записи: 68
04-06-2015 дата публикации

SOLVENT-FREE PROCESSING, SYSTEM AND METHODS

Номер: US20150152018A1
Автор: Elzinga Sytze, Raber Jeffrey C.
Принадлежит: THE WERC SHOP, LLC

Disclosed is a process for purifying one or more chemical constituents from plant matter using extraction with a fluid that is not a solvent, for example, with a vegetable oil. The extracted chemical constituents may then optionally be further processed by heating in order to induce desired chemical transformations. The extracted chemical constituents are also processed by concentrating at reduced pressure, for example, by distillation. 1. A method for purifying a chemical compound from plant matter , the method comprising:contacting the plant matter with a non-solvent; a non-solvent enriched in the chemical compound; and', 'plant matter residue;, 'extracting a chemical compound into the non-solvent to produce a mixture comprisingseparating the enriched non-solvent from the plant matter residue; andvolatilizing the chemical compound out of the enriched non-solvent to produce a purified chemical compound.2. The method of claim 1 , wherein the non-solvent comprises an oil.3. The method of claim 2 , wherein the oil is selected from a group consisting of plant oil claim 2 , vegetable oil claim 2 , fruit oil claim 2 , seed oil claim 2 , nut oil claim 2 , fish oil claim 2 , canola oil claim 2 , sunflower oil claim 2 , corn oil claim 2 , peanut oil claim 2 , walnut oil claim 2 , almond oil claim 2 , or a mixture thereof.4. The method of claim 1 , wherein the extracting step comprises one or more of mixing claim 1 , stirring claim 1 , and heating.5. The method of claim 1 , wherein the separating step involves straining claim 1 , filtering claim 1 , or centrifuging.6. The method of claim 5 , wherein the mixture is filtered through a food-grade straining mesh.7. The method of claim 5 , wherein the mixture is pressed through a mechanical press.8. The method of claim 1 , wherein the mixture is separated using an auger-type oil extractor.9. The method of claim 1 , wherein the volatilizing step comprises exposure to one or more of heat claim 1 , vacuum claim 1 , and partial ...

Подробнее
Номер записи: 69
25-05-2017 дата публикации

FUNCTIONALIZED ASPHALTENES AND METHODS THEREOF

Номер: US20170144897A1
Автор: SIDDIQUI Mohammad Nahid
Принадлежит: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

A functionalized asphaltene, obtained by refluxing with an acid solution. The functionalized asphaltene contains elevated levels of oxygen content due to nitration and oxidation of the refluxing process. The refluxing process also imparts organic functional groups including at least amines, nitro groups carbonyl groups, carboxylic groups and hydroxyl groups to the functionalized asphaltene, and these functional groups are attached to, thereby coating the surface of a functionalized asphaltene particle. A method for removing dye compounds from an aqueous sample with the functionalized asphaltene is also described. 1. A functionalized asphaltene , comprising:10-35% by weight of elemental oxygen per total weight of the functionalized asphaltene;3-10% by weight of elemental nitrogen per total weight of the functionalized asphaltene; and3-10% by weight of elemental sulfur per total weight of the functionalized asphaltene;wherein the functionalized asphaltene is obtained by refluxing a petroleum asphaltene with an acid, andwherein the functionalized asphaltene has at least one active group selected from the group consisting of an amine group, a nitro group, a carbonyl group, a carboxylic group and a hydroxyl group covalently bonded to an asphaltene core.2. The functionalized asphaltene of claim 1 , having an average particle size of 10-20 nm.3. The functionalized asphaltene of claim 1 , having a particle size distribution of 0.5-100 nm wherein at least 60% of the particles have a particle size of 10-20 nm.4. The functionalized asphaltene of claim 1 , having a specific surface area of no higher than 10 m/g.5. The functionalized asphaltene of claim 1 , having an adsorption average pore width of 1-10 nm.6. A process for preparing the functionalized asphaltene of claim 1 , comprising:refluxing an asphaltene-acid suspension at 70-90° C. for 1-2 h to form the functionalized asphaltene;wherein the asphaltene-acid solution comprises the petroleum asphaltene and the acid.7. The ...

Подробнее
Номер записи: 70
14-08-2014 дата публикации

METHOD FOR THE CATALYTIC REDUCTION OF ACID CHLORIDES AND IMIDOYL CHLORIDES

Номер: US20140228579A1
Автор: GUTSULYAK Dmitry, Lee Sun Hwa, Nikonov Georgii
Принадлежит: Brock Unviersity

The present application relates to methods for the catalytic reduction of acid chlorides and/or imidoyl chlorides. The methods comprise reacting the acid chloride or imidoyl chloride with a silane reducing agent in the presence of a catalyst such as [Cp(PrP)Ru(NCMe)][PF]. 2. The method of claim 1 , wherein Cpis unsubstituted η-cyclopentadienyl.3. The method of claim 1 , wherein the silane reducing agent is selected from dimethylphenylsilane claim 1 , triethylsilane claim 1 , methylphenylsilane and triphenylsilane.4. The method of claim 3 , wherein the silane reducing agent is dimethylphenylsilane.5. The method of claim 1 , wherein R claim 1 , Rand Rare each isopropyl.6. The method of claim 1 , wherein Rand Rare each CH.7. The method of claim 1 , wherein X is selected from [PF] claim 1 , [ClO] claim 1 , [B[3 claim 1 ,5-(CF)CH]] claim 1 , [B(CF)] claim 1 , [Al(OC(CF))] claim 1 , a carborane-based counteranion and a non-nucleophilic amide counteranion.8. The method of claim 1 , wherein the catalyst of Formula I is [Cp(PrP)Ru(NCMe)][PF].12. The method of claim 1 , wherein the catalyst is present in an amount of from about 0.2 mol % to about 20 mol % claim 1 , based on the amount of the compound being reduced.13. The method of claim 1 , wherein the reaction of the compound with the silane reducing agent is carried out in the presence of at least one solvent.14. The method of claim 13 , wherein the solvent is selected from chloroform claim 13 , dichloromethane claim 13 , acetone and acetonitrile.15. The method of claim 13 , wherein the solvent is selected from chloroform claim 13 , dichloromethane and acetone.16. The method of claim 15 , wherein the reaction of the compound with the silane reducing agent is further carried out in the presence of a Calkyl cyanide.17. The method of claim 16 , wherein the Calkyl cyanide is tBuCN or CHCN.18. The method of claim 17 , wherein the Calkyl cyanide is present in an amount of from about 5 mol % to about 250 mol % claim 17 , based on ...

Подробнее
Номер записи: 71
02-06-2016 дата публикации

PHOSPHORAMIDITE DERIVATIVES IN THE HYDROFORMYLATION OF UNSATURATED COMPOUNDS

Номер: US20160152539A1
Автор: BENETSKIY Eduard, BÖRNER Armin, DYBALLA Katrin Marie, Franke Robert, Fridag Dirk, SELENT Detlef
Принадлежит: EVONIK DEGUSSA GmbH

The invention relates to: a) phosphoramidites of formula (I), wherein Q is selected from substituted or unsubstituted 1,1′-biphenyl groups, Rstands for hydrogen, and Rstands for C-Calkyl groups, substituted or unsubstituted C-Ccycloalkyl groups, or phenyl groups and wherein Ris not a tertiary butyl group; b) transition-metal-containing compounds of the formula Me(acac)(CO)L, wherein Me=transition metal and L of the general formula (II): wherein Q is selected from substituted or unsubstituted 1,1′-biphenyl groups, Rstands for hydrogen, Rstands for C-Calkyl groups, substituted or unsubstituted C-Ccycloalkyl groups, or phenyl groups, and Ris not a tertiary butyl group and wherein the transition metal Me is selected from ruthenium, cobalt, rhodium, and iridium; c) catalytically active compositions in the hydroformylation, which comprise the compounds mentioned under a) and b); d) method for the hydroformylation of unsaturated compounds by using the catalytically active composition mentioned under c), and e) multi-phase reaction mixture, containing unsaturated compounds, gas mixture, which comprises carbon monoxide and hydrogen, aldehydes, and the catalytically active composition described under c). 5. Compound according to claim 3 , where the transition metal is rhodium.7. A process for hydroformylating unsaturated compounds comprising introducing the catalytically active composition according to .8. Process for hydroformylating unsaturated compounds using a catalytically active composition according to claim 6 , where the unsaturated compounds are selected from:hydrocarbon mixtures from steamcracking plants;hydrocarbon mixtures from catalytically operated cracking plants;hydrocarbon mixtures from oligomerization processes;hydrocarbon mixtures comprising polyunsaturated compounds;olefin-containing mixtures including olefins having up to 30 carbon atoms;unsaturated carboxylic acid derivatives.10. Polyphasic reaction mixture comprising:unsaturated compounds,a gas mixture ...

Подробнее
Номер записи: 72
09-06-2016 дата публикации

MONOPHOSPHITES COMPRISING AN ANTHROL

Номер: US20160159718A1
Автор: Boerner Armin, DYBALLA Katrin Marie, Franke Robert, Fridag Dirk, GEILEN Frank, HESS Dieter, SELENT Detlef
Принадлежит: EVONIK DEGUSSA GmbH

Monophosphites comprising an anthrol are useful for catalyzing hydroformylation of an olefin to an aldehyde. 2. The compound according to claim 1 ,{'sup': 1', '2', '3', '4', '5', '6', '7', '8, 'wherein R, R, R, R, R, R, R, Rare each independently selected from the group consisting of{'sub': 1', '12', '1', '12', '6', '20', '6', '20', '1', '12', '6', '20', '1', '12', '2, '—H, —(C-C)-alkyl, —O—(C-C)-alkyl, —O—(C-C)-aryl, —(C-C)-aryl, —S-alkyl, —S-aryl, halogen, —CO—(C-C)-alkyl, —CO—(C-C)-aryl, and —N[(C-C)-alkyl].'}3. The compound according to claim 1 ,{'sup': 9', '10', '11', '12', '13', '14', '15', '16', '17', '18, 'wherein R, R, R, R, R, R, R, R, R, Rare each independently selected from the group consisting of{'sub': 1', '12', '1', '12', '6', '20', '6', '20', '1', '12', '6', '20', '1', '12', '2, '—H, —(C-C)-alkyl, —O—(C-C)-alkyl, —O—(C-C)-aryl, —(C-C)-aryl, —S-alkyl, —S-aryl, halogen, —CO—(C-C)-alkyl, —CO—(C-C)-aryl, and —N[(C-C)-alkyl].'}4. The compound according to claim 1 ,{'sup': 1', '2', '3', '4', '5', '6', '7', '8, 'wherein R, R, R, R, R, R, R, Rare each independently selected from the group consisting of{'sub': 1', '12', '1', '12', '6', '20', '6', '20, '—H, —(C-C)-alkyl, —O—(C-C)-alkyl, —O—(C-C)-aryl, —(C-C)-aryl, —S-alkyl, -S-aryl, and halogen.'}5. The compound according to claim 1 ,{'sup': 9', '10', '11', '12', '13', '14', '15', '16', '17', '18, 'wherein R, R, R, R, R, R, R, R, R, Rare each independently selected from the group consisting of{'sub': 1', '12', '1', '12', '6', '20', '6', '20, '—H, —(C-C)-alkyl, —O—(C-C)-alkyl, —O—(C-C)-aryl, —(C-C)-aryl, —S-alkyl, —S-aryl, and halogen.'}6. The compound according to claim 1 ,{'sup': 1', '2', '3', '4', '5', '6', '7', '8, 'wherein R, R, R, R, R, R, R, Rare each independently selected from the group consisting of{'sub': 1', '12', '1', '12', '6', '20, '—H, —(C-C)-alkyl, —O—(C-C)-alkyl, and —O—(C-C)-aryl.'}7. The compound according to claim 1 ,{'sup': 9', '10', '11', '12', '13', '14', '15', '16', '17', '18, 'wherein ...

Подробнее
Номер записи: 73
09-06-2016 дата публикации

BISPHOSPHITES HAVING AN UNSYMMETRIC OUTER BIPHENOL UNIT

Номер: US20160159840A1
Автор: Boerner Armin, DYBALLA Katrin Marie, Franke Robert, Fridag Dirk, SELENT Detlef
Принадлежит: EVONIK DEGUSSA GmbH

Bisphosphites having at least one unsymmetric outer biphenol unit are useful for the hydroformylation of an olefin. 2. The compound according to claim 1 ,{'sup': 1', '2', '3', '4', '5', '6', '7', '8, 'wherein R, R, R, R, R, R, R, Rare each independently selected from the group consisting of{'sub': 1', '12', '1', '12', '6', '20, '—H, —(C-C)-alkyl, —O—(C-C)-alkyl, —O—(C-C)-aryl, —S-alkyl, and —S-aryl.'}3. The compound according to claim 1 ,{'sup': 1', '2', '3', '4', '5', '6', '7', '8, 'wherein R, R, R, R, R, R, R, Rare each independently selected from the group consisting of{'sub': 1', '12', '1', '12', '6', '20, '—H, —(C-C)-alkyl, —O—(C-C)-alkyl, and —O—(C-C)-aryl.'}4. The compound according to claim 1 ,{'sup': 1', '2', '3″', '4', '5', '6', '7', '8, 'wherein R″, R″, R, R″, R″, R″, R″, R″ are each independently selected from the group consisting of{'sub': 1', '12', '1', '12', '6', '20, '—H, —(C-C)-alkyl, —O—(C-C)-alkyl, and —O—(C-C)-aryl.'}5. The compound according to claim 1 ,{'sup': 1', '2', '3', '4', '5', '6', '7', '8, 'wherein R, R, R, R, R, R, R, Rare each independently selected from the group consisting of{'sub': 1', '12', '1', '12', '6', '20, '—H, —(C-C)-alkyl, —O—(C-C)-alkyl, and —O—(C-C)-aryl.'}6. The compound according to claims 1 ,{'sup': 1', '2', '3', '4', '5', '6', '7', '8, 'wherein R′, R′, R′, R′, R′, R′, R′, R′ are each independently selected from the group consisting of{'sub': 1', '12', '1', '12', '6', '20, '—H, —(C-C)-alkyl, —O—(C-C)-alkyl, and —O—(C-C)-aryl.'}7. The compound according to claim 1 ,{'sup': 1', '2', '3', '4', '5', '6', '7', '8, 'wherein R″, R″, R″, R″, R″, R″, R″, R″ are each independently selected from the group consisting of{'sub': 1', '12', '1', '12', '6', '20, '—H, —(C-C)-alkyl, —O—(C-C)-alkyl, and —O—(C-C)-aryl.'}8. The compound according to claim 1 ,{'sup': 1', '1′', '1, 'wherein R, R and R′ are the same radical; and'}{'sup': 8', '8', '8″, 'R, R′ and Rare the same radical.'}9. The compound according to claim 1 ,{'sup': 1', '8, ' ...

Подробнее
Номер записи: 74
07-06-2018 дата публикации

Process for the preparation of a purified acid composition

Номер: US20180155308A1
Автор: Ana Rita Martins Guerreiro Rocha ALMEIDA, Ana Sofia Vagueiro DE SOUSA DIAS, Ines Dacil GONZALEZ JIMENEZ, Martinus Mathilda Pieter Zieverink
Принадлежит: Synvina CV

A purified acid composition including 2,5-furandicarboxylic acid is prepared in a process, including oxidizing a feedstock containing 5-alkoxymethylfurfural to an oxidation product including 2,5-furandicarboxylic acid (FDCA) and 2-formyl-furan-5-carboxylic acid (FFCA), and esters of FDCA and, optionally, esters of FFCA; hydrolyzing the at least part of the oxidation product in the presence of water, thereby hydrolyzing at least esters of FDCA and, optionally, esters of FFCA to obtain an aqueous solution of an acid composition including FDCA, FFCA and ester of FDCA in an amount below the amount of ester of FDCA in the solution of the oxidation product; contacting at least part of the solution of the acid composition with hydrogen in the presence of a hydrogenation catalyst to hydrogenate FFCA to hydrogenation products, yielding a hydrogenated solution; and separating at least a portion of the FDCA from at least part of the hydrogenated solution by crystallization.

Подробнее
Номер записи: 75
07-06-2018 дата публикации

PROCESS FOR THE PREPARATION OF A PURIFIED ACID COMPOSITION

Номер: US20180155309A1
Автор: Almeida Ana Rita Martins Guerreiro Rocha, de Sousa Dias Ana Sofia Vagueiro, Zieverink Martinus Mathilda Pieter
Принадлежит:

A purified acid composition including 2,5-furandicarboxylic acid is prepared by a process including a) providing an acid composition solution of a crude acid composition in a polar solvent, the crude acid composition including 2,5-furandicarboxylic acid (FDCA) and 2-formyl-furan-5-carboxylic acid (FFCA); b) contacting the acid composition solution with hydrogen in the presence of a hydrogenation catalyst to hydrogenate FFCA to hydrogenation products, such that the hydrogenation products contain a minor amount of 2-methyl-furan-5-carboxylic acid (MFA) or no MFA, yielding a hydrogenated solution; c) separating at least a portion of the FDCA from the hydrogenated solution by crystallization. 1. A process for the preparation of a purified acid composition comprising 2 ,5-furandicarboxylic acid , comprising:a) providing an acid composition solution of a crude acid composition in a polar solvent, the crude acid composition comprising 2,5-furandicarboxylic acid (FDCA) and 2-formyl-furan-5-carboxylic acid (FFCA);b) contacting the acid composition solution with hydrogen in the presence of a hydrogenation catalyst to hydrogenate FFCA to hydrogenation products, such that the hydrogenation products contain up to a minor amount of 2-methyl-furan-5-carboxylic acid (MFA), yielding a hydrogenated solution; andc) separating at least a portion of the FDCA from the hydrogenated solution by crystallization.2. The process according to claim 1 , wherein the acid composition solution is contacted with hydrogen at a temperature in the range of 150 to 200° C. and a contact time with the hydrogenation catalyst in the range of 5 seconds to 15 min.3. The process according to claim 2 , wherein the acid composition solution is contacted with hydrogen at a temperature in the range of 150 to 200° C. and for a contact time with the hydrogenation catalyst of at most 10 min.4. The process according to claim 1 , wherein the hydrogenation catalyst comprises palladium on carbon.5. The process according ...

Подробнее
Номер записи: 76
07-06-2018 дата публикации

METHOD FOR PREPARING L-BPA

Номер: US20180155368A1
Автор: He Jing, Li Shihong, LIU Yuanhao, Wang Zheng
Принадлежит:

Provided is a method for preparing L-BPA, which includes steps of: reacting N-protected (S)-4-halophenylalanine of Formula I, a boronating agent, Grignard reagent and bis(2-methylaminoethyl)ether to obtain a reaction mixture, wherein the reaction mixture comprises N-protected (S)-4-boronophenylalanine of Formula II and the Rgroup represents a protecting group; 2. The method according to claim 1 , wherein the Rgroup of N-protected (S)-4-halophenylalanine of Formula I is iodide or bromide claim 1 , the Rgroup of N-protected (S)-4-halophenylalanine of Formula I and N-protected (S)-4-boronophenylalanine of Formula II is selected from the group consisting of: tert-butoxycarbonyl (t-Boc) group claim 1 , trityl (Trt) group claim 1 , 3 claim 1 ,5-dimethoxyphenylisopropoxycarbonyl (Ddz) group claim 1 , 2-(4-Biphenyl)isopropoxycarbonyl (Bpoc) group claim 1 , and 2-nitrophenylsulfenyl (Nps) group claim 1 , the boronating agent is trialkyl borate claim 1 , the Grignard reagent includes alkylmagnesium chloride claim 1 , alkylmagnesium bromide claim 1 , arylmagnesium chloride or arylmagnesium bromide.3. The method according to claim 1 , wherein the step of reacting N-protected (S)-4-halophenylalanine of Formula I claim 1 , a boronating agent claim 1 , Grignard reagent and bis(2-methylaminoethyl)ether to obtain a reaction mixture comprises reacting N-protected (S)-4-halophenylalanine of Formula I claim 1 , a boronating agent claim 1 , Grignard reagent and bis(2-methylaminoethyl)ether at a temperature ranging from 0° C. to 60° C. to obtain the reaction mixture.4. The method according to claim 1 , wherein the step of deprotecting the Rgroup of the N-protected (S)-4-boronophenylalanine to obtain L-BPA comprises deprotecting the Rgroup of the N-protected (S)-4-boronophenylalanine at a temperature ranging from 30° C. to 60° C. to obtain L-BPA.7. The method according to claim 6 , wherein the step of protecting the amine terminal of (S)-4-halophenylalanine of Formula VI to obtain N- ...

Подробнее
Номер записи: 77
14-05-2020 дата публикации

METHOD FOR PRODUCING PYRROLE COMPOUND

Номер: US20200148637A1
Автор: CHOI JINSOON, GOH GIHO, Kim Sunmi, Ouchi Takashi, PARK HUNSOO
Принадлежит: Takeda Pharmaceutical Company Limited

The present invention provides a production method of a 3-cyanopyrrole compound possibly useful as an intermediate for pharmaceutical products. A production method of compound (II) including subjecting compound (I) to a reduction reaction, in which the aforementioned reduction reaction is continuous hydrogenation reaction in a fixed bed reactor filled with a supported metal catalyst. A production method of compound (III) including subjecting compound (I) to a reduction reaction followed by a cyclization reaction, in which the aforementioned reduction reaction is continuous hydrogenation reaction in a fixed bed reactor filled with a supported metal catalyst. 2. (canceled)4. The production method according to wherein the supported metal catalyst comprises a metal selected from the group consisting of iron (Fe) claim 1 , nickel (Ni) claim 1 , palladium (Pd) claim 1 , platinum (Pt) claim 1 , rhodium (Rh) claim 1 , iridium (Ir) claim 1 , ruthenium (Ru) claim 1 , cobalt (Co) claim 1 , and a combination thereof.5. The production method according to wherein the supported metal catalyst comprises palladium (Pd) as a metal.6. The production method according to wherein the supported metal catalyst has a metal content of 0.1-15 wt % relative to the whole weight of the supported metal catalyst.7. The production method according to wherein the metal of the supported metal catalyst is supported by a carrier selected from the group consisting of carbon claim 1 , alumina claim 1 , silica claim 1 , silica-alumina claim 1 , zirconia claim 1 , titania claim 1 , zeolite claim 1 , calcium carbonate claim 1 , calcium carbonate-lead claim 1 , molecular sieve and polymer.8. The production method according to wherein the metal of the supported metal catalyst is supported by alumina as a carrier.9. The production method according to wherein the hydrogenation is performed in a solvent containing an acid.10. The production method according to wherein the acid is acetic acid.11. The production ...

Подробнее
Номер записи: 78
16-06-2016 дата публикации

ALKOXYLATED HUMUS MATERIAL COMPOSITIONS AND METHODS OF MAKING SAME

Номер: US20160168335A1
Автор: McDaniel Cato R., Pober Kenneth W.
Принадлежит:

A method of alkoxylating a humus material comprising heating a reaction mixture comprising a humus material, a C3+ cyclic ether, a catalyst and an inert reaction solvent, and recovering a C3+ alkoxylated humus material from the reaction mixture. A method of alkoxylating a humus material comprising heating a reaction mixture comprising a humus material, a C3+ cyclic ether, a catalyst and an inert reaction solvent to a temperature of from about 130° C. to about 170° C., wherein the humus material comprises leonardite, the C3+ cyclic ether comprises propylene oxide, and the inert reaction solvent comprises xylene, and recovering a C3+ alkoxylated humus material from the reaction mixture. A C3+ alkoxylated humus material. 1. A method of alkoxylating a humus material comprising:heating a reaction mixture comprising a humus material, a C3+ cyclic ether, a catalyst and an inert reaction solvent; andrecovering a C3+ alkoxylated humus material from the reaction mixture.24-. (canceled)68-. (canceled)1112-. (canceled)13. The method of wherein the strong base catalyst comprises sodium methoxide claim 23 , potassium methoxide claim 23 , sodium ethoxide claim 23 , potassium ethoxide claim 23 , or combinations thereof.1415-. (canceled)16. The method of wherein the strong acid catalyst comprises (a) a mixture of HF and at least one of a metal alkoxide and a mixed metal alkoxide; or (b) a mixture of esters of at least one of titanic and zirconic acid with monoalkanols and at least one of sulfuric acid claim 23 , alkanesulfonic acids and aryloxysulfonic acids.18. The method of wherein the inert reaction solvent comprises C-Cliquid aromatic hydrocarbons.19. The method of wherein the C-Cliquid aromatic hydrocarbon is selected from the group consisting of toluene claim 18 , ethylbenzene claim 18 , xylenes claim 18 , o-xylene claim 18 , m-xylene claim 18 , p-xylene claim 18 , trimethylbenzenes claim 18 , cumene claim 18 , mesitylene claim 18 , 1 claim 18 ,2 claim 18 ,4-trimethylbenzene ...

Подробнее
Номер записи: 79
14-06-2018 дата публикации

METHOD FOR THE PRODUCTION OF 2,4-DIHYDROXYBUTYRIC ACID

Номер: US20180162798A1
Автор: Genders David, Stapley Jonathan
Принадлежит: DFI USA, LLC

Methods for the production of 2,4-dihydroxybutyrate (2,4-DHB) from erythrose and other four-carbon sugars are disclosed. The improved methods facilitate the production of 2,4-DHB that is a precursor for biorenewable and animal nutrition chemicals among others. 1. A method of producing 2 ,4-dihydroxybutyrate , comprising: mixing a four carbon sugar and a hydroxide salt in solution.2. The method of claim 1 , wherein the four carbon sugar is threose or erythrulose.3. The method of claim 1 , wherein the temperature of the solution is maintained below 100° C.4. The method of claim 1 , wherein the four carbon sugar is diluted sufficiently to result in a molar yield of DHB that is greater than 40%.5. The method of claim 1 , wherein the four carbon sugar is diluted with a solution containing DHB.6. The method of claim 1 , wherein the method is performed in a continuous reactor system.7. The method of claims 1 , wherein the hydroxide concentration of the solution is between 0.1 M and 4 M.8. The method of claim 7 , wherein the temperature of the solution is maintained below 100° C.9. The method of claim 8 , wherein the four carbon sugar is diluted with a solution containing DHB.10. The method of claim 1 , further comprising removing oxygen from the solution.11. The method of claim 10 , wherein oxygen is removed by venting the solution with a gas selected from the group consisting of: nitrogen claim 10 , argon claim 10 , and mixtures of the same.12. The method of claim 10 , wherein oxygen is removed by venting the solution with hydrogen.13. The method of claim 1 , wherein the four carbon sugar is erythrose.14. The method of claim 13 , wherein the erythrose is diluted with a solution containing one or more other organic acid salts.15. The method of claim 13 , wherein the method is performed in a continuous reactor system.16. The method of claim 13 , wherein the erythrose is diluted with a solution containing DHB.17. The method of claim 13 , wherein the temperature of the ...

Подробнее
Номер записи: 80
21-05-2020 дата публикации

Manufacturing process for cyclodextrin derivatives

Номер: US20200157252A1
Автор: Jose R. Matos, Vincent D. Antle
Принадлежит: Cydex Pharmaceuticals Inc

A process and equipment assembly for reacting a substituent precursor with a cyclodextrin starting material to provide a raw product comprising a cyclodextrin derivative and 1% or less of an initial amount of the substituent precursor is provided. The process of the present invention provides cyclodextrin derivatives in substantially shorter time and with fewer side products than previous processes that utilize substantially the same starting materials.

Подробнее
Номер записи: 81
23-06-2016 дата публикации

CONVERSION OF ALKANES TO ORGANOSELENIUMS AND ORGANOTELLURIUMS

Номер: US20160176812A1
Автор: HASHIGUCHI Brian G., KONNICK Michael M., PERIANA Roy A.
Принадлежит: The Scripps Research Institute

The invention provides processes and materials for the efficient and costeffective functionalization of alkanes and heteroalkanes, comprising contacting the alkane or heteroalkane and a soft oxidizing electrophile comprising Se(VI) or Te(VI), in an acidic medium, optionally further comprising an aprotic medium, which can be carried out at a temperature of less than 300 C. Isolation of the alkylselenium or alkyltellurium intermediate allows the subsequent conversion to products not necessarily compatible with the initial reaction conditions, such as amines, stannanes, organosulfur compounds, acyls, halocarbons, and olefins. 1. A process for the conversion of an alkane or a heteroalkane , wherein the alkane or heteroalkane comprises at least one sp-hybridized carbon atom , to a corresponding alkylselenium or alkyltellurium compound comprising(a) contacting the alkane or heteroalkane and a soft oxidizing electrophile comprising Se(VI) or Te(VI), in an acidic medium, optionally further comprising an aprotic medium; to form the corresponding alkylselenium or alkyltellurium compound and optionally(b) separating the respective alkylselenium or alkyltellurium compound.2. The process of claim 1 , further comprising a step of regeneration of the soft oxidizing electrophile by contacting a Se- or Te-containing electrophile reduction product of the soft oxidizing electrophile and the alkane or heteroalkane with an oxidant under conditions suitable to regenerate the soft oxidizing electrophile comprising Se(VI) or Te(VI).3. (canceled)4. The process of claim 1 , wherein the alkane is methane claim 1 , ethane claim 1 , or propane claim 1 , or any mixture thereof.5. The process of claim 1 , wherein the acidic medium is free of a superacid.6. The process of claim 2 , wherein the regenerating oxidant comprises any of molecular oxygen claim 2 , hydrogen peroxide claim 2 , chlorine claim 2 , nitric acid claim 2 , or ozone.7. The process of claim 2 , wherein the regenerating oxidant ...

Подробнее
Номер записи: 82
21-06-2018 дата публикации

BENZO[H]QUINOLINE LIGANDS AND COMPLEXES THEREOF

Номер: US20180169641A1
Автор: BALDINO Salvatore, Baratta Walter, BLACKABY Andrew, BRYAN Richard Charles, FACCHETTI Sarah, Jurcik Václav, NEDDEN Hans Guenter
Принадлежит:

The present invention provides substituted tridentate benzo[h]quinoline ligands and complexes thereof. The invention also provides the preparation of the ligands and the respective complexes, as well as to processes for using the complexes in catalytic reactions. 16. A transition metal complex according to claim 15 , wherein M is ruthenium.17. A transition metal complex according to claim 15 , wherein Lis PRRR claim 15 , wherein Ru i claim 15 , Rand Rare claim 15 , independently claim 15 , unsubstituted C-alkyl claim 15 , substituted C-alkyl claim 15 , unsubstituted C-cycloalkyl claim 15 , substituted C-cycloalkyl claim 15 , unsubstituted C-alkoxy claim 15 , substituted C-alkoxy claim 15 , unsubstituted C-aryl claim 15 , substituted C-aryl claim 15 , unsubstituted C-heteroalkyl claim 15 , substituted C-heteroalkyl claim 15 , unsubstituted C-heterocycloalkyl claim 15 , substituted C-heterocycloalkyl claim 15 , unsubstituted C-heteroaryl or substituted C-heteroaryl.18. A transition metal complex according to claim 15 , wherein Lis a chiral or achiral claim 15 , monodentate or bidentate phosphorus ligand claim 15 , wherein the phosphorus atom in the phosphorus ligand is covalently bonded to 3 carbon atoms or n heteroatoms and 3-n carbon atoms claim 15 , where n=1 claim 15 , 2 or 3.19. A transition metal complex according to claim 18 , wherein the heteroatom is N or O.20. A transition metal complex according to claim 18 , wherein Lis an unsubstituted or substituted Binap ligand claim 18 , PPhos ligand claim 18 , PhanePhos ligand claim 18 , QPhos ligand claim 18 , Josiphos ligand claim 18 , Bophoz ligand claim 18 , a Skewphos ligand.21. A transition metal complex according to claim 18 , wherein Lis PPh claim 18 , dppf (1 claim 18 ,1′-bis(diphenylphosphino)ferrocene) claim 18 , dppp (1 claim 18 ,3-bis(diphenylphosphino)propane) claim 18 , dppb (1 claim 18 ,4-bis(diphenylphosphino)butane) claim 18 , Dipfc (1 claim 18 ,1′-bis(di-isopropylphosphino)ferrocene) claim 18 , or ...

Подробнее
Номер записи: 83
02-07-2015 дата публикации

CARBONYLATION CATALYST AND PROCESS USING SAME

Номер: US20150182957A1
Автор: Dunn Craig Steven, Lingerfelt Larry Ronnie, Moore Mary Kathleen, Tustin Gerald Charles, Zhu Zhidong George, Zoeller Joseph Robert
Принадлежит: EASTMAN CHEMICAL COMPANY

Carbonylation catalysts and methods for using them are disclosed. In some embodiments, the carbonylation catalyst includes the contact product of: 1. Carbonylation process for the production of esters , carboxylic acids or combinations of two or more of the foregoing comprising combining in a reaction zone at least one carbonylation feedstock compound selected from alkanols , dialkyl ethers , and combination of any two or more thereof with carbon monoxide in a carbonylation zone of a carbonylation reactor in the presence of a catalyst material , wherein the catalyst material comprises the contact product of:(a) a monomeric nitrogen-containing compound selected from pyridines and imidazoles;(b) a Group VIII metal; and(c) an alkali metal compound;wherein the catalyst material is on a solid support.2. The carbonylation process of wherein said carbonylation feedstock compound is methanol.3. The carbonylation process of wherein said carbonylation process occurs in the liquid phase.4. The carbonylation process of wherein said carbonylation process occurs in the vapor phase.5. The carbonylation process of wherein said Group VIII metal is selected from the group consisting of rhodium claim 1 , ruthenium claim 1 , cobalt claim 1 , iridium claim 1 , nickel claim 1 , palladium claim 1 , platinum and combinations thereof.6. The carbonylation process of wherein said Group VIII metal is rhodium.7. The carbonylation process of wherein said alkali metal compound is selected from lithium compounds.9. The carbonylation process of claim 8 , wherein the monomeric nitrogen-containing compound is a structure of Formula I claim 8 , and R claim 8 , R claim 8 , R claim 8 , and Rare each independently selected from hydrogen and C-Calkyl and Ris a phenyl group claim 8 , said phenyl group being optionally substituted with a C-Calkyl in a para-configuration around the phenyl ring with the other six-membered ring shown in Formula I.10. The carbonylation process of claim 9 , wherein R claim 9 , R ...

Подробнее
Номер записи: 84
18-09-2014 дата публикации

IN-SITU METHOD FOR PREPARING HYDROLYZED ACYL HALIDE COMPOUND

Номер: US20140264161A1
Автор: Jons Steven D., Koob Joseph D., Peery Martin H., Qiu XiaoHua Sam, Rosenberg Steven, Roy Abhishek, Tomlinson Ian A.
Принадлежит: Dow Global Technologies LLC

An in-situ method for preparing a hydrolyzed, acyl halide-containing compound by combining a reactant including a plurality of acyl halide functional groups containing reactant, a tri-hydrocarbyl phosphate compound and water within a hydrocarbon or halogenated hydrocarbon solvent. 2. The method of wherein the reactant and reaction product both have a molecule weight less than 700 amu (Daltons).3. The method of wherein the reactant and reaction product both have a molecule weight less than 300 amu (Daltons).4. The method of wherein the reactant and reaction product both comprise equal to or less than 30 carbon atoms.5. The method of wherein the reactant and reaction product both comprise from 4 to 12 carbon atoms6. The method of wherein the reactant comprises a carbon containing moiety selected from: an aliphatic or arene group substituted with a plurality of acyl halide functional groups; and the reaction product comprises an aliphatic or arene group substituted with at least one acyl halide functional group and a carboxylic acid functional group.7. The method of wherein the reaction product comprises an aliphatic or arene group substituted with at least one acyl halide functional group and single carboxylic acid functional group.8. The method of wherein the solution comprises:i) water at a concentration of less than 1 wt %,ii) the reactant at a concentration of less than 10 wt % andiii) the tri-hydrocarbyl phosphate compound at a concentration of less than 10 wt %.9. The method of wherein the solution comprises:i) water at a concentration of less than 0.5 wt %,ii) the reactant at a concentration of less than 5 wt %, andiii) the tri-hydrocarbyl phosphate compound at a concentration of less than 5 wt %.10. The method of wherein the solution comprises the reactant at a molar ratio with water from 1:2 to 100:1.11. The method of wherein the solution comprises the tri-hydrocarbyl phosphate compound at a molar ratio with the reactant of 10:1 to 1:100.12. The method of ...

Подробнее
Номер записи: 85
08-07-2021 дата публикации

Ylide-functionalised phosphanes for use in metal complexes and homogeneous catalysis

Номер: US20210205800A1
Автор: Thorsten SCHERPF, Viktoria DÄSCHLEIN-GESSNER
Принадлежит: Umicore AG and Co KG

The invention relates to ylide-functionalized phosphane ligands, the production of same and use in transition metal compounds, as well as the use of same as catalysts in organic reactions.

Подробнее
Номер записи: 86
08-07-2021 дата публикации

METHOD FOR OXIDATIVE CLEAVAGE OF COMPOUNDS WITH UNSATURATED DOUBLE BOND

Номер: US20210206702A1
Автор: CHEN Chien-Tien, CHEN Ya-Pei, Liao Yi-Ya
Принадлежит:

A method for oxidative cleavage of a compound with an unsaturated double bond is provided. The method includes the steps of: 2. The method of claim 1 , wherein Rand Rare each independently H claim 1 , Calkyl claim 1 , Ccycloalkyl claim 1 , Caryl claim 1 , or Cheteroaryl claim 1 , or Rand Rare fused to be Caralkyl; Ris H claim 1 , Calkyl claim 1 , Ccycloalkyl claim 1 , Caryl claim 1 , or Cheteroaryl.3. The method of claim 1 , wherein Lis selected from the group consisting of OTf claim 1 , OTs claim 1 , NTf claim 1 , halogen claim 1 , RC(O)CHC(O)R claim 1 , OAc claim 1 , OC(O)R claim 1 , OC(O)CF claim 1 , OMe claim 1 , OEt claim 1 , O-iPr claim 1 , and butyl claim 1 , wherein R is alkyl.5. The method of claim 4 , wherein the ligand containing C═N unit comprises pyridine claim 4 , oxazole claim 4 , oxazoline claim 4 , or imidazole.8. The method of claim 1 , wherein the catalyst represented by Formula (II) is MoOCl claim 1 , V(O)Cl claim 1 , V(O)(O-iPr) claim 1 , V(O)Cl claim 1 , V(O)(OAc) claim 1 , V(O)(OCCF) claim 1 , Ti(O)(acac) claim 1 , Zr(O)Cl claim 1 , Hf(O)Cl claim 1 , Nb(O)Cl claim 1 , MoO(acac) claim 1 , V(O)(OTs) claim 1 , VO(OTf) claim 1 , or V(O)(NTf).10. The method of claim 1 , wherein the trifluoromethyl-containing reagent is 3 claim 1 ,3-Dimethyl-1-(trifluoromethyl)-1 claim 1 ,2-benziodoxole claim 1 , 3 claim 1 ,3-Dimethyl-1-(perfluroalkyl)-1 claim 1 ,2-benziodoxole claim 1 , 3-oxo-1-(trifluoromethyl)-1 claim 1 ,2-benziodoxole claim 1 , 3-oxo-1-(perfluroalkyl)-1 claim 1 ,2-benziodoxole) claim 1 , trifluomethyl dibenzothiophenium salts claim 1 , perfluoroalkyl dibenzothiophenium salts claim 1 , CFSONa claim 1 , or CF(CF)SONa claim 1 , wherein n is an integer of 1 to 6. This application claims the benefits of the Taiwan Patent Application Serial Number 109100028, filed on Jan. 2, 2020, the subject matter of which is incorporated herein by reference.The present disclosure relates to a method of oxidative cleavage and, more particularly, to a method of ...

Подробнее
Номер записи: 87
30-06-2016 дата публикации

BISPHOSPHITES HAVING A CENTRAL 2,3'-BIPHENOL UNIT

Номер: US20160185685A1
Автор: Boerner Armin, DYBALLA Katrin Marie, Franke Robert, SELENT Detlef
Принадлежит: EVONIK DEGUSSA GmbH

Bisphosphites having a central 2,3′-biphenol unit are useful for catalyzing hydroformylation. 2. The compound according to claim 1 ,{'sup': 1', '2', '3', '4', '5', '6', '7', '8, 'wherein R, R, R, R, R, R, R, Rare each independently selected from the group consisting of{'sub': 1', '12', '1', '12', '6', '20, '—H, —(C-C)-alkyl, —O—(C-C)-alkyl, —O—(C-C)-aryl, —S-alkyl, and —S-aryl.'}3. The compound according to claim 1 ,{'sup': 1', '2', '3', '4', '5', '6', '7', '8, 'wherein R, R, R, R, R, R, R, Rare selected from the group consisting of{'sub': 1', '12', '1', '2', '6', '20, '—H, —(C-C)-alkyl, —O—(C-C)-alkyl, and —O—(C-C)-aryl.'}4. The compound according to claim 1 ,{'sup': 4', '5, 'wherein Rand Rare each —H.'}5. The compound according to claim 1 ,{'sup': 1', '2', '3', '4', '5', '6', '7', '8', '1', '2', '3', '4', '5', '6', '7', '8, 'wherein R′, R′, R′, R′, R′, R′, R′, R′, R″, R″, R′, R″, R″, R″, R″, R″ are each independently selected from the group consisting of{'sub': 1', '12', '1', '12', '6', '20, '—H, —(C-C)-alkyl, —O—(C-C)-alkyl, —O—(C-C)-aryl, —S-alkyl, and —S-aryl.'}6. The compound according to claim 1 ,{'sup': 1', '2', '3', '4', '5', '6', '7', '8', '1', '2', '3', '4', '5', '6', '7', '8, 'wherein R′, R′, R′, R′, R′, R′, R′, R′, R″, R″, R″, R″, R″, R″, R″, R″ are each independently selected from the group consisting of{'sub': 1', '2', '1', '12', '6', '20, '—H, —(C-C)-alkyl, —O—(C-C)-alkyl, and —O—(C-C)-aryl.'}7. The compound according to claim 1 ,{'sup': 1', '2', '3', '4', '5', '6', '7', '8', '1', '2', '3', '4', '5', '6', '7', '8, 'wherein R′, R′, R′, R′, R′, R′, R′, R′, R″, R″, R″, R″, R″, R″, R″, R″ are each —H.'}8. The compound according to claim 1 ,{'sup': 9', '10', '11', '12', '9', '10', '11', '2, 'sub': 6', '20, 'wherein R′, R′, R′, R′, R″, R″, R″, R″ are each —(C-C)-aryl.'}9. The compound according to claim 1 ,{'sup': 9', '10', '11', '12', '9', '10', '11', '12, 'wherein R′, R′, R′, R′, R″, R″, R″, R″ are each phenyl.'}10. The compound according to claim 1 ,{' ...

Подробнее
Номер записи: 88
28-06-2018 дата публикации

NEW METHOD FOR TRANSFORMING SUGARS AND SUGAR ALCOHOLS INTO MONO- AND POLY-OXIDIZED COMPOUNDS IN THE PRESENCE OF A HETEROGENEOUS CATALYST

Номер: US20180179131A1
Автор: BRULE Emilie, Cabiac Amandine, DELCROIX Damien, GIRARD Etienne, Jacquin Marc
Принадлежит: IFP ENERGIES NOUVELLES

The invention concerns a method for converting a feedstock selected from sugars or sugar alcohols, alone or in a mixture, into mono- or polyoxygenated compounds, wherein the feedstock is contacted with at least one heterogeneous catalyst comprising a support selected from perovskites of formula ABO, in which A is selected from the elements Mg, Ca, Sr and Ba and B is selected from the elements Fe, Mn, Ti and Zr, and the oxides of elements selected from lanthanum, neodymium, yttrium and cerium, alone or in a mixture, which oxides can be doped with at least one element selected from alkali metals, alkaline earths and rare earths, in a reducing atmosphere, at a temperature of 100° C. to 300° C. and at a pressure of 0.1 MPa to 50 MPa. 1. Method for transforming a feedstock that is selected from among sugars and sugar alcohols , by themselves or in a mixture , into mono- or poly-oxidized compounds , in which said feedstock is brought into contact with at least one heterogeneous catalyst , in the same reaction chamber , in the presence of at least one solvent , with said solvent being water , an alcohol , a diol , or another solvent , by itself or in a mixture , under a reducing atmosphere , and at a temperature of between 100° C. and 300° C. , and at a pressure of between 0.1 MPa and 50 MPa , and in which said heterogeneous catalyst(s) comprise(s) at least one metal that is selected from among the metals of groups 8 to 11 of the periodic table and a substrate that is selected from among the perovskites of formula ABOin which A is selected from among the elements Mg , Ca , Sr and Ba , and B is selected from among the elements Fe , Mn , Ti and Zr , and the oxides of elements that are selected from among lanthanum , neodymium , yttrium , cerium , by themselves or in a mixture , with said oxides able to be doped by at least one element that is selected from among the alkaline metals , the alkaline-earths , and the rare earths , by themselves or in a mixture , with said method ...

Подробнее
Номер записи: 89
18-09-2014 дата публикации

OXIDATION PROCESS

Номер: US20140275621A1
Автор: Donen Steven, Hash Kirk, Smith Tyler
Принадлежит:

A process utilizing nitric acid and oxygen as co-oxidants to oxidize aldehydes, alcohols, polyols, preferably carbohydrates, specifically reducing sugars to produce the corresponding carboxylic acids. 1. A method of synthesizing a mixture of organic acids , the method comprising the steps of:(a) combining, over time, in one or more closed reaction vessels, under a positive pressure of oxygen and with continuous mixing, an organic compound suitable for nitric acid oxidation and an aqueous solution of nitric acid to form a first reaction mixture, wherein the organic compound and the aqueous solution of nitric acid are introduced into the one or more closed reaction vessels;(b) flowing said first reaction mixture through the one or more reaction vessels while maintaining a controlled temperature of from about 5° C. to about 105° C. and controlled positive pressure of oxygen of from about 0 bar g to about 1000 bar g for a time period suitable to oxidize the organic compound to a subsequent reaction mixture comprising a mixture of organic acid products and nitrogen oxides;(c) recirculating the subsequent reaction mixture to the reaction vessel vapor space headspace; and(d) recovering nitric acid from the subsequent reaction mixture.2. The method of claim 1 , wherein the one or more closed reaction vessels comprises one or more reactors.3. The method of claim 2 , wherein the one or more closed reaction vessels are in series (continuous) or in parallel with one another (batch).4. The method of claim 2 , wherein the reactor is a continuously stirred tank reactor (CSTRs) or a tubular type plug flow reactor.5. The method of claim 1 , wherein the method is a continuous process.6. The method of claim 1 , wherein the method is a batch process.7. The method of claim 1 , wherein the organic compound comprises a single organic material or a mixture of organic materials suitable for nitric acid oxidation.8. The method of claim 1 , further comprising the step of removing a ...

Подробнее
Номер записи: 90
18-09-2014 дата публикации

NITRIC ACID OXIDATION PROCESS

Номер: US20140275622A1
Автор: Donen Steven, Jensen Keith
Принадлежит:

A process utilizing nitric acid and oxygen as co-oxidants to oxidize aldehydes, alcohols, polyols, preferably carbohydrates, specifically reducing sugars to produce the corresponding carboxylic acids. 1. A method of synthesizing a mixture of organic acids , the method comprising the steps of:(a) combining, over time, in one or more closed reaction vessels, under a positive pressure of oxygen and with continuous stirring mixing an organic compound suitable for nitric acid oxidation and an aqueous solution of nitric acid to form a reaction mixture, wherein the organic compound and the aqueous solution of nitric acid are concurrently introduced into the one or more closed reaction vessels;(b) flowing said reaction mixture through the one or more closed reaction vessels while (i) maintaining a controlled temperature of from about 5° C. to about 105° C. in a portion of the reaction vessel, (ii) maintaining a reaction vessel headspace temperature of from about 80° C. to about −42° C.; and (iii) a controlled positive pressure of oxygen of from about 0 bar g to about 1000 bar g for a time period suitable to oxidize the organic compound to a subsequent reaction mixture comprising a mixture of organic acid products and nitrogen oxides; and(c) removing most of nitric acid from the subsequent reaction mixture to give a final reaction mixture of organic acids suitable for further processing.2. The method of claim 1 , wherein the one or more closed reaction vessels comprises one or more reactors.3. The method of claim 2 , wherein the one or more closed reaction vessels are in series (continuous) or in parallel (batch) with one another.4. The method of claim 2 , wherein the reactor is a continuously stirred tank reactor (CSTRs) or a tubular type plug flow reactor.5. The method of claim 1 , wherein the method is a continuous process.6. The method of claim 1 , wherein the method is a batch process.7. The method of claim 1 , wherein the organic compound comprises a single organic ...

Подробнее
Номер записи: 91
18-09-2014 дата публикации

Nitric acid oxidation processes

Номер: US20140275623A1
Автор: Keith Jensen, Kirk Hash, Steven Donen, Tyler Smith
Принадлежит: RIVERTOP RENEWABLES Inc

A process utilizing nitric acid and oxygen as co-oxidants to oxidize aldehydes, alcohols, polyols, preferably carbohydrates, specifically reducing sugars to produce the corresponding carboxylic acids.

Подробнее
Номер записи: 92
05-07-2018 дата публикации

SYNTHESIS AND APPLICATION OF MICROBUBBLE-FORMING COMPOUNDS

Номер: US20180185272A1
Автор: GRUBBS Robert H., Marx Vanessa M.
Принадлежит:

The present disclosure is directed to fatty-acid glycerol ester derivative compounds containing a targeting bisphosphonate group. The disclosure further include pharmaceutical or biomedical compositions comprising these compounds, and methods of using these compounds and compositions forming microbubbles. The microbubbles have affinity for metal-containing, especially calcium-containing, bodies and/or biological targets. In certain embodiments, these compositions are useful for providing targeted placement of microbubbles capable of cavitation on application of high frequency energy. 7. The compound of claim 4 , wherein each m is independently selected from 14-22.8. The compound of claim 4 , wherein each m is independently selected from 14-22; X is silyl claim 4 , and each Ris hydrogen or C-Calkyl.14. The method of claim 13 , wherein the method further comprises the subsequent steps of:4) contacting the carbamate intermediate with a Lewis acid under non-aqueous conditions; and5) adding a protic acid.16. The method of claim 15 , wherein Lewis acid is trimethylsilyl bromide; and the protic acid is methanol.17. The method of claim 13 , wherein the carboxy coupling reagent is para-nitro-phenylchloroformate (PNPCl).18. The method of claim 9 , wherein the carboxy coupling reagent is 1′-Carbonyldiimidazole (CDI).19. The method of claim 13 , wherein the activated intermediate is not isolated.23. A pharmaceutical or biomedical composition comprising one or more compounds of -.24. The pharmaceutical or biomedical composition of claim 23 , wherein the composition is a suspension.25. The pharmaceutical or biomedical composition of claim 23 , wherein the composition is a colloid.26. The pharmaceutical or biomedical composition of claim 23 , wherein the composition is an emulsion.27. The pharmaceutical or biomedical composition of claim 23 , wherein the composition is an aerosol.28. The pharmaceutical or biomedical composition of claim 23 , wherein the composition is a sol.29. ...

Подробнее
Номер записи: 93
05-07-2018 дата публикации

ETHYLENE-TO-LIQUIDS SYSTEMS AND METHODS

Номер: US20180186707A1
Автор: Abudawoud Raed Hasan, Black Richard, Crisci Anthony, Czerpak Peter, GRAUER David C., Michalak William, Nyce Greg, Patel Bipinkumar, Radaelli Guido, Rappold Tim A., Zhang Aihua
Принадлежит:

The present disclosure provides petrochemical processing methods and systems, including ethylene conversion processes and systems, for the production of higher hydrocarbon compositions, for example liquid hydrocarbon compounds, with reduced amount of unsaturated hydrocarbons. 171.-. (canceled)72. A method for generating oxygenate compounds with five or more carbon atoms (Coxygenates) , comprising:{'sub': 2', '4', '2', '4', '5+, '(a) directing an unsaturated hydrocarbon feed stream comprising ethylene (CH) into an ethylene-to-liquids (ETL) reactor that converts said CHin an ETL process to yield a product stream comprising compounds with five or more carbon atoms (Ccompounds); and'}{'sub': 5+', '5+, '(b) directing at least a portion of said product stream from said ETL reactor into a hydration unit that reacts said Ccompounds in said at least said portion of said product stream in a hydration process to yield an oxygenate product stream comprising said Coxygenates.'}73. The method of claim 72 , wherein said Ccompounds comprise olefins claim 72 , and wherein said method further comprises converting said olefins to said oxygenate product stream comprising said Coxygenates.74. The method of claim 72 , wherein subsequent to (b) claim 72 , said product stream comprises at most about 10 wt % olefins.75. The method of claim 72 , wherein said hydration unit comprises a hydration catalyst that facilitates a hydration reaction in said hydration process.76. The method of claim 75 , wherein said hydration catalyst comprises an acid catalyst selected from the group consisting of water soluble acids claim 75 , organic acids claim 75 , metal organic frameworks (MOF) claim 75 , and solid acids.77. The method of claim 72 , wherein (b) further comprises directing water into said hydration reactor claim 72 , wherein said water reacts with said Ccompounds in said hydration process to yield said Coxygenates.78. The method of claim 77 , wherein a molar ratio of said water to said ...

Подробнее
Номер записи: 94
05-07-2018 дата публикации

METHOD FOR PRODUCING PYRROLE COMPOUND

Номер: US20180186736A1
Автор: CHOI JINSOON, GOH GIHO, Kim Sunmi, Ouchi Takashi, PARK HUNSOO
Принадлежит:

The present invention provides a production method of a 3-cyanopyrrole compound possibly useful as an intermediate for pharmaceutical products. A production method of compound (II) including subjecting compound (I) to a reduction reaction, in which the aforementioned reduction reaction is continuous hydrogenation reaction in a fixed bed reactor filled with a supported metal catalyst. A production method of compound (III) including subjecting compound (I) to a reduction reaction followed by a cyclization reaction, in which the aforementioned reduction reaction is continuous hydrogenation reaction in a fixed bed reactor filled with a supported metal catalyst. 4. The production method according to wherein the supported metal catalyst comprises a metal selected from the group consisting of iron (Fe) claim 1 , nickel (Ni) claim 1 , palladium (Pd) claim 1 , platinum (Pt) claim 1 , rhodium (Rh) claim 1 , iridium (Ir) claim 1 , ruthenium (Ru) claim 1 , cobalt (Co) claim 1 , and a combination thereof.5. The production method according to wherein the supported metal catalyst comprises palladium (Pd) as a metal.6. The production method according to wherein the supported metal catalyst has a metal content of 0.1-15 wt % relative to the whole weight of the supported metal catalyst.7. The production method according to wherein the metal of the supported metal catalyst is supported by a carrier selected from the group consisting of carbon claim 1 , alumina claim 1 , silica claim 1 , silica-alumina claim 1 , zirconia claim 1 , titania claim 1 , zeolite claim 1 , calcium carbonate claim 1 , calcium carbonate-lead claim 1 , molecular sieve and polymer.8. The production method according to wherein the metal of the supported metal catalyst is supported by alumina as a carrier.9. The production method according to wherein the hydrogenation is performed in a solvent containing an acid.10. The production method according to wherein the acid is acetic acid.11. The production method ...

Подробнее
Номер записи: 95
05-07-2018 дата публикации

SUBSTITUTED BENZOTRIAZOLE PHENOLS

Номер: US20180186757A1
Автор: Li Fuming B., Schultz Nathan E., Volp Kelly A.
Принадлежит:

Benzotriazole phenols with substituents either ortho to the phenol hydroxyl group and/or para to the phenol hydroxyl group can be prepared from the unsubstituted benzotriazole phenol by coupling reactions. The ortho substituent group can be a simple alkoxy or amino group, or the ortho substituent group can be a linking group, linking the benzotriazole phenol to another benzotriazole phenol group. 2. The composition of claim 1 , wherein Rcomprises an —O—Rgroup wherein Rcomprises:an alkyl group with 1-20 carbon atoms; oran aryl group; and{'sup': '3', 'Ris an alkyl group with 1-20 carbon atoms.'}3. The composition of claim 2 , wherein Rcomprises:an alkyl group with 1-6 carbon atoms; oran aryl group comprising a substituted phenyl group.5. The composition of claim 4 , wherein Rcomprises:an alkyl group with 1-6 carbon atoms; oran aryl group comprising a 3-alkyl substituted phenyl group, wherein the alkyl substituted group has 1-6 carbon atoms;{'sup': '10', 'Rcomprises a hydrogen atom.'}6. The composition of claim 1 , wherein Rcomprises a hydrogen atom; Rcomprises an alkoxy group comprising 4 carbon atoms; and each R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and R claim 1 , independently comprises a hydrogen atom.7. The composition of claim 2 , wherein Rcomprises an —O—Rgroup wherein Rcomprises an alkyl group with 4 carbon atoms; and{'sup': '3', 'Ris an alkyl group with 1-20 carbon atoms.'}8. The composition of claim 2 , wherein Rcomprises an —O—Rgroup wherein Rcomprises an aryl group comprising a 3-methyl phenyl group claim 2 , or a 4-methyl phenyl group; and{'sup': '3', 'Ris an alkyl group with 1-20 carbon atoms.'}9. The composition of claim 4 , wherein Rcomprises an —N—RRgroup wherein Rcomprises an alkyl group with 1 carbon atom claim 4 , or an alkyl group with 6 carbon atoms;{'sup': '10', 'Rcomprises a hydrogen atom; and'}{'sup': '3', 'Ris an alkyl group with 1-20 carbon atoms.'}10. The composition of claim 4 , wherein Rcomprises an —N—RRgroup wherein ...

Подробнее
Номер записи: 96
22-07-2021 дата публикации

METHOD FOR PRODUCING TOBACCO FLAVOR LIQUID, TOBACCO FLAVOR LIQUID, METHOD FOR PRODUCING ESTER COMPOUND, AND SMOKING ARTICLE

Номер: US20210219596A1
Автор: YAMAUCHI Shun
Принадлежит: JAPAN TOBACCO INC.

The purpose of the present invention is to provide a method for producing a tobacco flavor liquid that is useful for smoking articles, the tobacco flavor liquid, a method for producing an ester compound, and a smoking article that contains the tobacco flavor liquid. 1. A method for producing a tobacco flavor liquid , the method comprising:extracting a component from a starting tobacco material using an organic solvent to thereby obtain a tobacco component-containing liquid; andmixing the tobacco component-containing liquid with an aqueous solution comprising a basic substance and an alcohol in an oxygen-containing atmosphere to react the tobacco component-containing liquid with the aqueous solution, thereby obtaining a tobacco flavor liquid.2. The method according to claim 1 , wherein the reaction is performed at 0° C. to 90° C.3. The method according to claim 1 , whereinthe aqueous solution is a mixed solution of a water solution of the basic substance and the alcohol, andthe water solution of the basic substance has a pH of 11.0 to 14.0.4. The method according to claim 1 , wherein the basic substance is a hydroxide of an alkali metal or an alkaline earth metal.5. The method according to claim 1 , wherein the basic substance is strongly basic.6. The method according to claim 1 , wherein the aqueous solution is a mixed solution of a water solution of the basic substance and the alcohol claim 1 , andthe basic substance is present in the water solution of the basic substance at a concentration of 0.01 N to 5 N,7. The method according to claim 1 , wherein the organic solvent included in the tobacco component-containing liquid is immiscible with the aqueous solution.8. The method according to claim 1 , wherein a proportion of a volume of the alcohol in a total of a volume of the tobacco component-containing liquid and a volume of the aqueous solution is 2.0% to 28.6%.9. The method according to claim 1 , wherein the reaction is performed over a period of 1 to 60 minutes. ...

Подробнее
Номер записи: 97
11-06-2020 дата публикации

DECOMPOSITION OF ORGANIC PEROXIDES AND HYDROGEN PEROXIDE BY THE IRON THIOLATES AND RELATED COMPLEXES

Номер: US20200181038A1
Автор: Dussault Patrick H., Olson Andrew
Принадлежит:

Disclosed herein is a method of reducing or disproportionating peroxide, comprising combining an organic chalcogenide, an iron salt, and the peroxide in the presence of an additional reductant, which can be the organic chalcogenide. The method can be used to, e.g., prepare alcohols from peroxides and to disproportionate hydrogen peroxide into water and oxygen. 1. A method of decomposing a peroxide , comprising combining:an organic chalcogenide;an optional reductant;an iron salt; andthe peroxide;wherein decomposing the peroxide comprises reducing the peroxide or disproportionating the peroxide.29.-. (canceled)11. The method of claim 10 , wherein R′ is (i) hydrogen.12. The method of claim 10 , wherein R′ is (ii) Calkyl optionally substituted with 1-3 R.1319.-. (canceled)20. The method of claim 10 , wherein Ris (ii) Calkyl optionally substituted with 1-3 R.2128.-. (canceled)29. The method of claim 1 , wherein Rand R claim 1 , taken together with the oxygen atoms they are bonded to claim 1 , form a 5-10-membered heterocyclyl comprising 1-6 heteroatoms selected from O claim 1 , S claim 1 , and N claim 1 , wherein the heterocyclyl is optionally substituted with 1-6 R.3041.-. (canceled)42. The method of claim 1 , wherein the organic chalcogenide is a thiolate of Formula A2:{'br': None, 'sup': 10', '−, 'R—S'}wherein:{'sup': '10', 'claim-text': [{'sub': '1-6', 'sup': 'm', '(i) Calkyl optionally substituted with from 1-4 R;'}, {'sub': '6-10', 'sup': 'm', '(ii) —Caryl optionally substituted with from 1-4 R;'}, {'sup': 'm', '(iii) -5-10 membered heteroaryl, wherein 1-4 ring atoms are each independently selected from the group consisting of N, NH, O, and S, wherein the heteroaryl is optionally substituted with from 1-4 R;'}, {'sub': '3-10', 'sup': 'm', '(iv) —Ccycloalkyl wherein the cycloalkyl is optionally substituted with from 1-4 R; and'}, {'sup': 'm', '(v) —5-10 membered heterocyclyl, wherein the heterocyclyl is optionally substituted with 1-4 R;'}], 'Ris selected from the ...

Подробнее
Номер записи: 98
25-09-2014 дата публикации

PROCESS FOR THE THERMOCHEMICAL CONVERSION OF A CARBON-BASED FEEDSTOCK TO SYNTHESIS GAS CONTAINING PREDOMINANTLY H2 AND CO

Номер: US20140288195A1
Автор: Boissonnet Guillaume, Castelli Pierre
Принадлежит: Commissariat A L'Energie Atomique Et Aux Energies Alternatives

The invention relates to a novel process for the thermochemical conversion of a carbon-based feedstock to synthesis gas containing predominantly hydrogen (H) and carbon monoxide (CO). The process comprises (a) oxycombustion of the carbon-based feedstock to create a cogeneration of electricity and of heat; (b) high-temperature electrolysis (HTE) of water using at least the heat produced according to step (a); and (c) reverse water gas shift (RWGS) reaction starting from the carbon dioxide (CO) produced according to step (a) and the hydrogen (H) produced according to step (b). 1. Process for the thermochemical conversion of a carbon-based feedstock to synthesis gas containing predominantly hydrogen (H) and carbon monoxide (CO) , comprising the following steps:(a) oxycombustion of the carbon-based feedstock to create a cogeneration of electricity and of heat;(b) high-temperature electrolysis (HTE) of water using at least the heat produced according to step (a);{'sub': 2', '2, '(c) reverse water gas shift (RWGS) reaction starting from the carbon dioxide (CO) produced according to step (a) and the hydrogen (H) produced according to step (b).'}2. Process for the thermochemical conversion of a carbon-based feedstock to synthesis gas according to claim 1 , wherein the high-temperature electrolysis (HTE) of water of step (b) is also carried out using the electricity produced according to step (a).3. Process for the thermochemical conversion of a carbon-based feedstock to synthesis gas according to claim 1 , wherein all the oxygen produced by the electrolysis (HTE) according to step (b) is used as oxidising agent of the oxycombustion step (a).4. Process for the thermochemical conversion of a carbon-based feedstock to synthesis gas according to claim 1 , wherein only part of the oxygen produced by the electrolysis (HTE) according to step (b) is used as oxidising agent of the oxycombustion step (a) claim 1 , the other part being recovered.5. Process for the thermochemical ...

Подробнее
Номер записи: 99
27-06-2019 дата публикации

PROCESS FOR THE DIRECT CONVERSION OF ALKENES TO CARBOXYLIC ACIDS

Номер: US20190194110A1
Автор: Beller Matthias, DONG Kaiwu, Franke Robert, Jackstell Ralf, KUCMIERCZYK Peter, SANG Rui
Принадлежит: EVONIK DEGUSSA GmbH

Process for the direct conversion of alkenes to carboxylic acids. 2. Process according to claim 1 ,wherein the substance in process step b) is selected from:{'sub': 2', '2', '2', '2', '2', '3', '2, 'PdCl, PdBr, Pd(acac), Pd(dba)(dba=dibenzylideneacetone), PdCl(CHCN).'}3. Process according to claim 1 ,wherein the process comprises the additional process step e):e) addition of acetic acid.4. Process according to claim 1 ,wherein the process comprises additional process step f):f) addition of water.5. Process according to claim 1 ,wherein the process comprises the additional process step g):g) addition of p-toluenesulfonic acid.6. Process according to claim 1 ,wherein the reaction mixture is heated to a temperature in the range from 80° C. to 160° C. in process step d).7. Process according to claim 1 ,wherein the CO is fed in in process step c) such that the reaction proceeds under a CO pressure in the range from 20 bar to 60 bar, The invention relates to a process for the direct conversion of alkenes to carboxylic acids.Carboxylic acids are used in the preparation of polymers, pharmaceuticals, solvents and food additives. The routes leading to carboxylic acids generally include the oxidation of hydrocarbons, alcohols or aldehydes, the oxidative cleavage of olefins by ozonolysis, the hydrolysis of triglycerides, nitriles, esters or amides, the carboxylation of Grignard or organolithium reagents, and the halogenation and subsequent hydrolysis of methyl ketones in the haloform reaction.The object of the invention was to provide a process with which alkenes can be directly converted to a carboxylic acid.In the context of this application, “direct conversion” is intended to mean that the reaction takes place in one step, i.e. without separation or work-up or similar of an intermediate product.This does not exclude, in the course of the reaction, intermediates forming which are directly converted onward.The object is achieved by a process according to claim .Process ...

Подробнее
Номер записи: 100