Fragmentation Reagents For Mass Spectrometry

A mass spectrometry electron transfer dissociation reagent comprising an unsaturated compound having a Frank Condon factor between 0.1 and 1.0 and an electron affinity having a positive value between 0.1 to 150 kJ/mol. 1. A mass spectrometry electron transfer dissociation reagent comprising an unsaturated compound having a Frank Condon factor between 0.1 and 1.0 and an electron affinity having a positive value between 0.1 to 200 kJ/mol.2. The reagent of claim 1 , wherein the unsaturated compound is a substituted aromatic or conjugated aliphatic compound.3. The reagent of claim 1 , wherein the electron affinity has a positive value between 0.1 to 150 kJ/mol claim 1 , preferably 0.1 to 100 kJ/mol.4. The reagent of claim 1 , wherein the unsaturated compound is an aromatic compound claim 1 , wherein the nucleus of the aromatic compound is substituted with one or more substituents consisting of cyano claim 1 , nitro claim 1 , nitroso claim 1 , carboxyl claim 1 , iodo claim 1 , aldehyde and acetoxy.5. The reagent of claim 4 , wherein the one or more substituents are cyano.6. The reagent of claim 4 , wherein the nucleus is selected from the group consisting of phenyl claim 4 , pyridinyl claim 4 , pyrimidinyl claim 4 , triazolyl claim 4 , styrenyl and picolinyl.7. The reagent of claim 1 , wherein the unsaturated compound is an unsaturated aliphatic compound selected from the group consisting of ethylene claim 1 , acetylene or acrylate substituted with one or more substituents.8. The reagent of claim 7 , wherein two or more unsaturated bonds are conjugated.9. The reagent of claim 7 , wherein the unsaturated aliphatic compound is selected from the group consisting of ethylene claim 7 , acetylene or acrylate substituted with one or more unsaturated groups selected from the group consisting off cyano claim 7 , nitro claim 7 , aceto claim 7 , carboxyl claim 7 , aldehyde and nitroso.10. The reagent of selected from the group consisting of 1 claim 1 ,4-dicyanobenzene claim 1 , 1 ...

NOVEL PROCESS FOR PREPARING PHENYLCYCLOPROPYLAMINE DERIVATIVES USING NOVEL INTERMEDIATES

Provided herein is a novel process for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity. 2. The process of claim 1 , wherein the halogen atom in the compounds of formulae II claim 1 , III claim 1 , IV claim 1 , V claim 1 , VI and VII is F; and wherein the leaving group ‘X’ in the compound of formula VIII is Cl.3. The process of claim 1 , wherein the R claim 1 , Rand Rin the compounds of formulae II claim 1 , III claim 1 , IV claim 1 , V claim 1 , VI and VII are H claim 1 , and wherein the Rand Rare F.4. The process of claim 1 , wherein the first solvent used in step-(a) is selected from the group consisting of an aliphatic or alicyclic hydrocarbon claim 1 , a chlorinated aliphatic or aromatic hydrocarbon claim 1 , an aromatic mono or dinitro hydrocarbon claim 1 , and mixtures thereof; wherein the second solvent used in step-(b) is selected from the group consisting of a ketone claim 1 , an aliphatic amide claim 1 , a nitrile claim 1 , a hydrocarbon claim 1 , a cyclic ether claim 1 , an aliphatic ether claim 1 , a polar aprotic solvent claim 1 , and mixtures thereof; wherein the third solvent used in step-(c) is selected from the group consisting of a hydrocarbon claim 1 , a cyclic ether claim 1 , an aliphatic ether claim 1 , a chlorinated hydrocarbon claim 1 , and mixtures thereof; wherein the fourth solvent used in step-(d) is selected from the group consisting of a hydrocarbon claim 1 , cyclic ethers claim 1 , an ether claim 1 , an ester claim 1 , a nitrile claim 1 , an aliphatic amide claim 1 , a chlorinated hydrocarbon claim 1 ...

Nitrated Lipids and Methods of Making and Using Thereof

Described herein are nitrated lipids and methods of making and using the nitrated lipids. 179-. (canceled)80. A compound comprising a lipid comprising at least one nitro group , wherein the compound is substantially pure.81. A method for producing a nitrated lipid , comprising(a) reacting an unsaturated lipid with a mercuric salt, a selenium compound, and a nitrating compound to produce a first intermediate, and(b) reacting the first intermediate with an oxidant.82. The method of claim 81 , wherein step (a) is performed under anaerobic conditions.83. The method of claim 81 , wherein step (a) is conducted under anhydrous conditions.84. The method of claim 81 , wherein the mercuric salt comprises HgCl claim 81 , Hg(NO) claim 81 , or Hg(OAc).85. The method of claim 81 , wherein the selenium compound comprises PhSeBr claim 81 , PhSeCl claim 81 , PhSeOCCF claim 81 , PhSeOH claim 81 , or PhSeCN.86. The method of claim 81 , wherein the nitrating compound comprises a nitrite salt.87. The method of claim 81 , wherein the nitrating compound comprises NaNOor AgNO.88. The method of claim 81 , wherein the oxidant comprises HOor an organic hydroperoxide.89. The method of claim 81 , wherein the lipid comprises 14:1 claim 81 , 16:1 claim 81 , 18:1 claim 81 , 18:2 claim 81 , 18:3 claim 81 , 20:4 claim 81 , or 22:6 claim 81 , the mercuric salt comprises HgCl claim 81 , the selenium compound comprises PhSeBr claim 81 , the nitrating compound comprises NaNO claim 81 , and the oxidant comprises HO.90. The method of claim 89 , wherein step (a) is performed under anaerobic and anhydrous conditions.91. The method of claim 81 , wherein when after step (b) two or more isomers of the nitrated lipid are produced claim 81 , separating each isomer so that each isomer is substantially pure.92. The method of claim 91 , wherein the separation step comprises chromatographing the isomers.93. A nitrated lipid produced by the method of .94. A method for reducing or preventing inflammation in a subject ...

INTERMEDIATE COMPOUNDS AND PROCESS FOR THE PREPARATION OF FINGOLIMOD

The present invention relates to processes for the preparation of (2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride (Fingolimod) and pharmaceutically acceptable salts thereof, and intermediates formed in such processes. 142-. (canceled)44. The process according to claim 43 , wherein step (a) is conducted in the presence of a Friedel-Crafts catalyst claim 43 , a metal salt of an organic acid claim 43 , or a protic acid claim 43 , wherein{'sub': 3', '3', '4', '4', '2', '3, 'the Friedel Crafts catalyst is selected from AlCl, FeCl, SnCl, TiCl, ZnCland BF;'}the metal salt of an organic acid is a metal triflate selected from hafnium triflate and cerium triflate; and{'sub': 2', '4', '3', '3, 'the protic acid is selected from HF, HSO, CFSOH and an ion-exchange resin which is selected from Nafion or zeolite.'}45. The process according to claim 43 , wherein the reducing agent in step (b) is NaBH.46. The process according to claim 43 , wherein the hydroxy protecting group P in compound (13A) is acetyl (COCH) claim 43 , and wherein in step (c) the protection of 3-nitro-1-(4-octylphenyl)propan-1-ol is carried out by acylation with acetic anhydride or acetyl chloride in the presence of a base.47. The process according to claim 43 , whereinthe reduction of 3-nitro-1-(4-octylphenyl)propan-1-one (12) to 3-nitro-1-(4-octylphenyl)propan-1-ol and its conversion to compound (13A) is carried out in one step without isolation of intermediates; orwherein in step (d) the bis-hydroxymethylation of compound (13A) is carried out with formaldehyde or paraformaldehyde in the presence of a base; orwherein in step (d) the bis-hydroxymethylation of compound (13A) and deprotection to compound (14) is carried out in one step without isolation of intermediates.48. The process according to claim 43 , wherein the reduction step (e) comprises hydrogenating compound (14) to Fingolimod (1) in the presence of a Pd/C catalyst.50. The process according to claim 49 , wherein step (a) is ...

PROCESS FOR THE PRODUCTION OF AMIDES

The present invention relates to a process for the preparation of compounds of formula I 2. A compound of formula IV according to claim 1 , wherein Rand Rare methyl.4. A compound of formula IV prepared by the process of . This application is a divisional application of U.S. Ser. No. 13/198,739 filed Jan. 8, 2013, which is a divisional application of U.S. Ser. No. 12/066,683 filed Jul. 16, 2008, which is a 371 of International Application No. PCT/EP2006/008982 filed Sep. 14, 2006, which claims priority to CH 01520/05 filed Sep. 16, 2005 and CH 0296/06 filed Feb. 24, 2006, the contents of which are incorporated herein by reference.The present invention relates to a process for the preparation of pyrazolyl-4-carboxylic acid benzo-norbornen-5-yl-amides and also to novel intermediates for use in such a process. The present invention further relates to a novel crystal modification of syn-3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (9-isopropyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide, compositions comprising it and to the use thereof in the control of fungus infestation in cultivated plants.Pyrazolyl-4-carboxylic acid benzonorbornen-5-yl-amides, for example 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (9-isopropyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide, are valuable fungicides, such as are described, for example, in WO 04/035589.WO 04/035589 describes a process for the preparation of pyrazolyl-4-carboxylic acid benzonorbornen-5-yl-amides (see Scheme 1):According to WO 04/035589, a 3-nitro-dehydrobenzene generated, for example, from 6-nitro-anthralinic acids of formula (A) wherein Rand Rmay be, inter alia, hydrogen, is first reacted in a Diels-Alder reaction with a cyclic 1,4-diene of formula (B) wherein R, R, Rand Rmay be, inter alia, hydrogen and Y may be, inter alia, —CH((i)-CH)—, to form a 5-nitro-benzonorbornadiene compound of formula (C). Subsequent catalytic reduction under standard conditions (for example, Ra/Ni or ...

New palladium catalyst, method for its preparation and its use

The invention relates to palladium(0) tris{tri-[3,5-bis(trifluoromethyl)-phenyl]-phosphine} complex of formula (I), as well as to its preparation and use. This compound is outstandingly stable, and can be used as catalyst with excellent results.

Apparatus and Process for Nitration Selectivity Flexibility Enabled by Azeotropic Distillation

Disclosed are processes and apparatuses for concentrating at least one organic acid using an alkyl acetate as an entrainer. The processes and apparatuses may use the same alkyl acetate as an entrainer to concentrate a mixture of organic acids. 1. A process comprising:reacting a hydrocarbon feedstock with an aqueous feedstock in a reactor to produce a product stream comprising a nitroalkane and byproducts;processing the product stream to produce a first top stream and a first bottom stream, wherein the first top stream comprises the nitroalkane and the first bottom stream comprises at least a first organic acid and water;supplying at least a portion of the first bottom stream to an azeotropic distillation column;using an alkyl acetate as an entrainer in the azeotropic distillation column, such that the first bottom stream is separated into at least a second top stream and a second bottom stream, wherein the second top stream comprises the alkyl acetate and water and wherein the second bottom stream comprises the first organic acid;separating the second top stream in a phase separator into an organic phase and an aqueous phase, the organic phase comprising the alkyl acetate; andreturning at least a portion of the organic phase to the azeotropic distillation column.2. A process according to claim 1 , wherein the aqueous feedstock comprises water claim 1 , between about 10 and 50 weight percent of nitric acid claim 1 , and at least about 15 weight percent of the first organic acid.3. A process according to claim 1 , wherein the aqueous feedstock comprises at least about 40 weight percent of the first organic acid.4. A process according to claim 1 , wherein the first organic acid is selected from the group consisting of acetic acid claim 1 , propionic acid claim 1 , butyric acid claim 1 , and any combination thereof.5. A process according to claim 1 , wherein the first bottom stream further comprises at least a second organic acid.6. A process according to claim 5 , ...

PROCESS FOR SCRUBBING DINITROTOLUENE

The invention relates to a process for scrubbing a crude mixture comprising dinitrotoluene, nitric acid, nitrogen oxides and sulfuric acid obtained in the nitration of toluene after the nitrating acid has been separated off, which comprises two scrubbing steps (SS-I) and (SS-II), wherein 1. A process for scrubbing a crude mixture comprising dinitrotoluene , nitric acid , nitrogen oxides and sulfuric acid obtained in the nitration of toluene after the nitrating acid has been separated off , the process comprising:i) extracting a crude mixture with a scrubbing acid I comprising nitric acid, nitrogen oxides and sulfuric acid in a scrub comprising at least one extraction stage, such that scrubbing acid discharged from a first extraction stage (SS-I-1) of the extracting i) has a total acid content of from 20 to 40% by weight, to obtain a prescrubbed crude mixture;ii) extracting, the prescrubbed crude mixture comprising dinitroluene with a scrubbing acid II in a scrub comprising at least one extraction stage, such that scrubbing acid discharged from a first extraction stage (SS-II-1) of the extracting ii) has a pH of less than or equal to 4, to obtain a mixture comprising dinitrotoluene which is essentially free of nitric acid, sulfuric acid and nitrogen oxides.2. The process according to claim 1 , wherein the extracting i) comprises from 2 to 4 extraction stages and is carried out in countercurrent.3. The process according to claim 1 , wherein the extracting ii) comprises from 2 to 4 extraction stages and is carried out in countercurrent.4. The process according to claim 1 , wherein the scrubbing acid discharged from the first extraction stage (SS-II-1) of the extracting ii) has a pH of from 0 to 3.5. The process according to claim 1 , wherein the scrubbing acid discharged from the first extraction stage (SS-II-1) of the extracting ii) has a pH of from 0.5 to 2.6. The process according to claim 1 , wherein water or a scrubbing acid having a total acid content of from 0.2 ...

METHOD FOR PRODUCING FIVE-MEMBERED RING-CONTAINING COMPOUND

The present invention provides a method that allows production of stereospecific and asymmetrical five-membered ring-containing compounds serving as synthetic intermediates for formation of five-membered rings of prostaglandins and the like, with high yield and excellent stereoselectivity in terms of diastereoselectivity and enantioselectivity in a short process without requiring troublesome procedures such as optical resolution. The method for producing a five-membered ring-containing compound includes a cyclization step of condensing and cyclizing an α,β-unsaturated nitro compound represented by the following chemical formula (I) with a 1,4-butanedione compound, in the presence of a catalyst formed by a compound having a pyrrolidine ring and an optically active α-carbon relative to the nitrogen on the ring, in a water-insoluble organic solvent and/or a non-oxygen atom-containing water-soluble organic solvent so as to produce the five-membered ring-containing compound represented by the following chemical formula (II). 2. The method for producing a five-membered ring-containing compound according to claim 1 , further comprising claim 1 , after the cyclization step claim 1 , a reduction step of reducing claim 1 , with a reducing agent claim 1 , the Athat is the aldehyde group to the hydroxymethyl group.6. The method for producing a five-membered ring-containing compound according to claim 1 , wherein the water-insoluble organic solvent is at least one selected from a halogen-containing organic solvent claim 1 , an aromatic organic solvent claim 1 , a hydrocarbon organic solvent and an acyclic ether organic solvent claim 1 , and the non-oxygen atom-containing water-soluble organic solvent is a nitrile-substituted hydrocarbon organic solvent.7. The method for producing a five-membered ring-containing compound according to claim 6 , wherein the water-insoluble organic solvent is the halogen-containing organic solvent selected from dichloromethane claim 6 , ...

NONAQUEOUS ELECTROLYTE, ENERGY STORAGE DEVICE, AND METHOD FOR PRODUCING ENERGY STORAGE DEVICE

Provided is a nonaqueous electrolyte capable of suppressing swelling of an energy storage device caused by repeated charge-discharge, an energy storage device including the nonaqueous electrolyte, and a method for producing the energy storage device. One aspect of the present invention is a nonaqueous electrolyte which is used for an energy storage device and contains halogenated toluene and halogenated nitrotoluene. Another aspect of the present invention is an energy storage device including the nonaqueous electrolyte. Another aspect of the present invention is a method for producing an energy storage device, which uses the nonaqueous electrolyte. 1. A nonaqueous electrolyte which is used for an energy storage device and comprises halogenated toluene and halogenated nitrotoluene.2. The nonaqueous electrolyte according to claim 1 , wherein the halogenated toluene is fluorotoluene.3. The nonaqueous electrolyte according to claim 1 , wherein a content of the halogenated toluene is 0.1% by mass or more and 8% by mass or less based on a total mass of the nonaqueous electrolyte.4. The nonaqueous electrolyte according to claim 1 , wherein the halogenated nitrotoluene is fluoronitrotoluene.5. The nonaqueous electrolyte according to claim 1 , wherein a content of the halogenated nitrotoluene is 0.001% by mass or more and 3% by mass or less based on the total mass of the nonaqueous electrolyte.6. An energy storage device comprising the nonaqueous electrolyte according to .7. A method for producing an energy storage device claim 1 , the method using the nonaqueous electrolyte according to . The present invention relates to a nonaqueous electrolyte, an energy storage device, and a method for producing an energy storage device.Nonaqueous electrolyte secondary batteries typified by lithium ion secondary batteries are widely used in electronic apparatuses such as personal computers and communication terminals, automobiles and the like because of their high energy density. In ...

Substitute diphenylamine compounds use thereof as antitumor agents

The invention relates to substituted diphenylamine compounds using as antitumor agents. The structure of the compounds is represented as the general formula (I): The groups are as defined as specification. The compound represented by formula (I) showed potent antitumor activity, especially to cure or alleviate the cancer causing by cancer cells of human tissue or organ. The preferred cancers are: colon cancer, liver cancer, lymph cancer, lung cancer, esophageal cancer, breast cancer, central nervous system cancer, melanoma, ovarian cancer, cervical cancer, renal cancer, leukemia, prostatic cancer, pancreatic cancer, bladder cancer, rectal cancer, osteosarcoma, nasopharynx cancer or stomach cancer.

PROCESS FOR THE PREPARATION OF BENZONORBORNENES

The present invention relates to a novel a process for the preparation of 9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine which process comprises a) reacting cyclopentadiene in the presence of a radical initiator and CXCl3, wherein X is chloro or bromo, to a compound of formula II, or aa) reacting cyclopentadiene with CXCl3, wherein X is chloro, in the presence of a metal catalyst to a compound of formula II, wherein X is chloro, b) reacting the compound of formula II with a base in the presence of an appropriate solvent to the compound of formula III, c) and converting the compound of formula III in the presence of 1,2-dehydro-6-nitrobenzene to the compound of formula IV, and d) hydrogenating the compound of formula IV in the presence of a metal catalyst. 1. A compound of formula IV This application is a divisional of U.S. patent application Ser. No. 14/603857, filed Jan. 23, 2015 which is a divisional of U.S. patent application Ser. No. 13/126380 filed Apr. 27, 2011, now patented as U.S. Pat. No. 9,115,043 issued Aug. 25, 2015, which was a 371 application of International Application No. PCT/EP2009/062525, filed Sep. 28, 2009, which claims priority to EP Patent Application 08018721.4, filed Oct. 27, 2008, and EP Patent Application No. 09161388.5 filed May 28, 2009, the contents of which are incorporated herein by reference herein.The present invention relates to the preparation of 9-dichloromethylene-1,2,3,4-tetrahydro-1, 4-methano-naphthalen-5-ylamine.The compound 9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine is a valuable intermediate for the preparation of benzonorbornene fungicides, as described for example in WO 2007/048556.It is known from WO 2007/048556 to prepare 9-dichloromethylene-1,2,3,4-tetrahydro-1, 4-methano-naphthalen-5-ylamine bya) reacting the compound of formula Ain the presence of an alkyl nitrite with a compound of formula Bwherein R′ and R″ are e.g. C-Calkyl, to a compound of formula Cb) ...

Biobased plasticizer and surface covering employing same

Described herein are biobased plasticizer compositions comprising a compound having the structure of Formula I: wherein R is C 6 -C 1 alkyl; along with methods of making and using same.

PROCESS AND PLANT FOR THE ADIABATIC NITRATION OF AROMATIC COMPOUNDS

The invention relates to a method for preferably adiabatic nitration of nitratable aromatic organic compounds (aromatics) and to a corresponding plant, in particular a production plant (nitration plant) for carrying out said method. 115-. (canceled)16. A process for the adiabatic nitration of nitratable aromatic organic compounds for producing the corresponding nitrated aromatic organic compounds ,wherein the nitratable aromatic organic compounds are converted, via a nitration reaction in the presence of a nitrating acid mixture comprising nitric acid and sulfuric acid, into the corresponding nitrated aromatic organic compounds,wherein the corresponding nitrated aromatic organic compounds are added to a reaction starting mixture, which reaction starting mixture comprises (i) the nitratable aromatic organic compounds to be nitrated and (ii) a nitrating acid mixture comprising nitric acid and sulfuric acid, and wherein the nitration reaction is started and carried out in the presence of the corresponding nitrated aromatic organic compounds; andwherein the nitrated aromatic organic compounds obtained are partly recirculated to the nitration reaction and the subsequent nitration reaction is started and carried out in the presence of these nitrated aromatic organic compounds;wherein the nitration reaction is carried out under adiabatic reaction conditions,wherein the nitration reaction is carried out in a tube reactor, andwherein the amount of corresponding nitrated aromatic organic compounds added to the nitration reaction is selected in such a way that the amount of added nitrated aromatic organic compounds effects lowering of the interfacial tension between organic phase and acid phase and effects an improved dispersibility of organic phase and acid phase.17. The process as claimed in claim 16 ,wherein the spent nitrating acid mixture resulting after the nitration reaction is recycled and circulated to the nitration reaction after the crude nitrated aromatic organic ...

PROCESS AND INTERMEDIATES FOR THE PREPARATION OF NEP INHIBITORS

The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route. 7. The process according to claim 6 , comprising the step of simultaneously or separately esterifiying the obtained compound of formula (1) claim 6 , or a salt thereof claim 6 , wherein R1 is hydrogen claim 6 , with a C-C-aliphatic alcohol claim 6 , to yield the compound of formula (1) wherein R1 is C-C-alkyl.15. (canceled)19. (canceled)21. (canceled)24. (canceled) The present invention relates to a new chemical synthesis route and intermediates useful for the preparation of neprilysin (NEP) inhibitors and their prodrugs, in particular for the NEP inhibitor prodrug sacubitril.The NEP inhibitor prodrug sacubitril (N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester; IUPAC name 4-{[(1S,3R)-1-([1,1′-biphenyl]-4-ylmethyl)-4-ethoxy-3-methyl-4-oxobutyl]amino}-4-oxobutanoic acid) is represented by the following formula (A)Sacubitril together with valsartan, a known angiotensin receptor blocker (ARB), forms a sodium salt hydrate complex, known as LCZ696, comprising the anionic forms of sacubitril and valsartan, sodium cations and water molecules in the molar ratio of 1:1:3:2.5, respectively (ratio of 6:6:18:15 in the asymmetric unit cell of the solid state crystal), and which is schematically present in formula (B).Said complex is also referred to by the following chemical names: Trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3′-methyl-2′-(pentanoyl{2″-(tetrazol-5-ylate)biphenyl-4′-ylmethyl}amino)butyrate] hemipentahydrate or Octadecasodium hexakis(4-{[(1S,3R)-1-([1,1′-biphenyl]-4-ylmethyl)-4-ethoxy-3-methyl-4-oxobutyl]amino}-4-oxobutanoate) hexakis(N-pentanoyl-N-{[2′-(1H-tetrazol-1-id-5-yl)[1,1′-biphenyl]-4-yl]methyl}-L- ...

Methods for synthesis of graphene derivatives and functional materials from asphaltenes

Embodiments described are directed to methods for the functionalization of asphaltene materials and to compositions made from functionalized asphaltenes. Disclosed is a method for synthesizing graphene derivatives, such as 2D single crystalline carbon allotropes of graphene and functional materials, such as sulfonic acid and its derivatives. Also disclosed is a method for the transformation of asphaltene into a source of graphene derivatives and functional materials, such as, 0D, 1D, 2D and combinations of 0D and 1D by utilizing chemical substitution reaction mechanism, such as, electrophilic aromatic substitution, nucleophilic aromatic substitution and Sandmeyer mechanism. Also disclosed are novel graphene materials comprising: acetylenic linkage and hydrogenated graphene. These novel materials, which may be produced by these methods, include, e.g.: 2D single crystalline carbon allotropes of graphene with asymmetric unit formulas C 7 H 6 N 2 O 4 , C 6 H 4 N 2 O 4 , C 7 H 7 O 3 S− H 3 O+, C 7 H 7 O 3 SH+, and a 2D single crystal with asymmetric unit formula (Na 6 O 16 S 4 )n.

NITRATED HYDROCARBONS, DERIVATIVES, AND PROCESSES FOR THEIR MANUFACTURE

Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications. 2. The compound of selected from formula I-1.3. The compound of claim 2 , wherein Rand Rare unsubstituted.4. The compound of claim 2 , wherein the compound is selected from the group consisting of 3-nitrodecane claim 2 , 4-nitrodecane claim 2 , 5-nitrodecane claim 2 , 4-nitrotridecane claim 2 , 5-nitrotridecane claim 2 , 7-nitrotridecane claim 2 , 2-nitrotetradecane claim 2 , 3-nitrotetradecane claim 2 , 4-nitrotetradecane claim 2 , 5-nitrotetradecane claim 2 , 6-nitrotetradecane claim 2 , 7-nitrotetradecane claim 2 , 2-nitropentadecane claim 2 , 3-nitropentadecane claim 2 , 4-nitropentadecane claim 2 , 5-nitropentadecane claim 2 , 6-nitropentadecane claim 2 , 7-nitropentadecane claim 2 , 8-nitropentadecane claim 2 , 3-nitrohexadecane claim 2 , 4-nitrohexadecane claim 2 , 5-nitrohexadecane claim 2 , 6-nitrohexadecane claim 2 , 7-nitrohexadecane claim 2 , 8-nitrohexadecane claim 2 , 2-nitroheptadecane claim 2 , 3-nitroheptadecane claim 2 , 4-nitroheptadecane claim 2 , 5-nitroheptadecane claim 2 , 6-nitroheptadecane claim 2 , 7-nitroheptadecane claim 2 , 8-nitroheptadecane claim 2 , 9-nitroheptadecane claim 2 , 3-nitrooctadecane claim 2 , 4-nitrooctadecane claim 2 , 5-nitrooctadecane claim 2 , 6-nitrooctadecane claim 2 , 7-nitrooctadecane claim 2 , 8-nitrooctadecane claim 2 , and 9-nitrooctadecane.5. The compound of selected from formula II-1.6. The compound of claim 5 , wherein Ris a linear C-Calkyl; and Ris H claim 5 , linear C-Calkyl claim 5 , or CHOH.7. The compound of claim 5 , wherein Ris H or linear C-Calkyl claim 5 , and Rand R claim 5 , together with the carbon to which they are attached form a linear C-Calkyl ...

Method of Manufacturing Nitrone Compound

A method of manufacturing nitrone compounds is provided. The method includes: providing a nitro compound; and performing a photoreaction of the nitro compound, a catalyst and an additive under visible light to obtain the nitrone compound. 1. A method of manufacturing nitrone compound , comprising:providing a nitro compound; andperforming a photoreaction of the nitro compound, a catalyst and an additive under visible light to obtain the nitrone compound.2. The method of claim 1 , wherein the catalyst is Ru(bpy)Cl.6HO claim 1 , Ru(bpy)Cl claim 1 , Ru(bpy)(BF) claim 1 , Ru(bpy)(PF) claim 1 , Ir[dF(CF)ppy](dtbbpy)(PF) or Ir(ppy)(dtbbpy)(PF).3. The method of claim 1 , wherein a wavelength of the visible light is within the range of 350 to 700 nm.4. The method of claim 3 , wherein a wavelength of the visible light is within the range of 450 to 460 nm.5. The method of claim 1 , wherein the nitro compound is a second order or third order nitro compound.6. The method of claim 1 , wherein the additive is diisopropylethylamine (DIPEA) claim 1 , diisopropylisobutylamine (DIPIBA) or a derivative of 1 claim 1 ,4-Dihydropyridine (DHP).7. The method of claim 6 , wherein when the additive is diisopropylisobutylamine (DIPIBA) claim 6 , an aldehyde compound is further added in the photoreaction.8. The method of claim 6 , wherein the derivative of 1 claim 6 ,4-Dihydropyridine (DHP) is Hantzsch ester.9. The method of claim 1 , wherein the catalyst is performed a photoredox catalyst reaction in the photoreaction. This application claims priority from Taiwan Patent Application No. 104125714, filed on Aug. 6, 2015, in the Taiwan Intellectual Property Office, the content of which are hereby incorporated by reference in their entirety for all purposes.1. Field of the InventionThe present invention relates to a manufacturing method, in particular with respect to a manufacturing method of manufacturing nitrone compound.2. Description of the Related ArtNitrone compound is a key intermediate for ...

CELL SEEDING PLATE, METHOD FOR MANUFACTURING THE SAME, AND CELL SHEET SEPARATING METHOD

A cell seeding plate comprises a substrate and a photolysis layer formed on a surface of the substrate. The photolysis layer comprises a plurality of photolysis groups, and each of the plurality of photolysis groups has a chemical structural formula of 2. The cell seeding plate of claim 1 , wherein the substrate is transparent claim 1 , and made of plastic or glass.3. The cell seeding plate of claim 1 , wherein Ris a natural polymer comprising sulfur group or a synthetic polymer comprising sulfur group claim 1 , the natural polymer is selected from collagen claim 1 , hyaluronic acid claim 1 , protein for functionalizing cell claim 1 , or peptides for functionalizing cell.6. The method of claim 5 , wherein the substrate is transparent claim 5 , and made of plastic or glass.9. The cell sheet separating method of claim 8 , wherein the substrate is transparent claim 8 , and made of plastic or glass. The subject matter herein generally relates to a cell seeding plate, a method for manufacturing the cell seeding plate, and a cell sheet separating method using the cell seeding plate.Cells are usually seeded on a thermoresponsive plate to form a cell sheet. The whole thermoresponsive plate can be deformed when cooled, thus allowing the cell sheet to be separated from the thermoresponsive plate. However, an activity of the cells may be decreased when cooled.It will be appreciated that for simplicity and clarity of illustration, where appropriate, reference numerals have been repeated among the different figures to indicate corresponding or analogous elements. In addition, numerous specific details are set forth in order to provide a thorough understanding of the embodiments described herein. However, it will be understood by those of ordinary skill in the art that the embodiments described herein can be practiced without these specific details. In other instances, methods, procedures, and components have not been described in detail so as not to obscure the related relevant ...

METHOD FOR CONTINUOUS PRODUCTION OF NITROBENZENE

The invention relates to a method for producing nitrobenzene, in which crude nitrobenzene is first produced by nitrating benzene and said crude nitrobenzene is then washed in succession in at least one acid wash, in at least one alkaline wash and in at least one neutral wash, at least one additional wash with an aqueous solution of a potassium salt being interposed between the last alkaline wash and the first neutral wash. 1. Method for producing nitrobenzene bya) nitration of benzene with nitric acid or mixtures of nitric acid and sulfuric acid and subsequent phase separation into an aqueous phase and an organic phase containing nitrobenzene,b) washing of the organic nitrobenzene-containing phase obtained in step a) in at least one wash and subsequent phase separation into an aqueous phase and an organic phase containing nitrobenzene, sodium hydroxide, sodium carbonate and sodium hydrogen carbonate,', 'and subsequent phase separation into an aqueous phase and an organic phase containing nitrobenzene,, 'c) washing of the organic nitrobenzene-containing phase obtained in step b) in at least one alkaline wash with an aqueous solution of a base selected from the group consisting of'}d) washing of the organic nitrobenzene-containing phase obtained in step c) in at least one wash with an aqueous solution of a potassium salt and subsequent phase separation into an aqueous phase and an organic phase containing nitrobenzene,e) washing of the organic nitrobenzene-containing phase obtained in step d) in at least one neutral wash with water and subsequent phase separation into an aqueous phase and an organic phase containing nitrobenzene,f) processing of the organic nitrobenzene-containing phase obtained in step e), wherein purified nitrobenzene is obtained.2. Method according to claim 1 , wherein in step c) an aqueous solution of sodium hydroxide is used.3. Method according to or claim 1 , wherein in step d) a molar ratio of potassium to sodium ions of 1:1 to 20:1 is ...

ARYL COMPOUNDS AND POLYMERS AND METHODS OF MAKING AND USING THE SAME

Disclosed herein are embodiments of aryl compounds and polymers thereof that are made using methods that do not require harsh conditions or expensive reagents. The methods disclosed herein utilize precursor compounds that can be polymerized to form polycyclic aromatic hydrocarbons and polymers, such as carbon-based polymers like nanostructures (e.g., graphene or graphene-like nanoribbons). 2. The compound of claim 1 , wherein the heteroaliphatic moiety comprises at least one carbon atom and one or two sulfur atoms.3. The compound of claim 1 , wherein each Rindependently is a thiol.4. The compound of claim 1 , wherein each Rindependently is a thioether.6. The compound of claim 5 , wherein the electron-donating group is an alkoxy group.9. The compound of claim 8 , wherein the electron-donating group is an alkoxy group. This application is a continuation of U.S. application Ser. No. 16/696,790, filed Nov. 26, 2019, which is a continuation of U.S. application Ser. No. 15/558,978, filed on Sep. 15, 2017, issued as U.S. Pat. No. 10,550,056 on Feb. 4, 2020, which is the U.S. National Stage of International Application No. PCT/US2016/023179, filed Mar. 18, 2016, which was published in English under PCT Article 21(2), which claims the benefit of, and priority to, the earlier filing date of U.S. Provisional Patent Application No. 62/135,692, filed on Mar. 19, 2015, and U.S. Provisional Patent Application No. 62/182,351, filed on Jun. 19, 2015; each of these prior applications is herein incorporated by reference in its entirety.The present disclosure concerns aryl compounds and polymeric aryl compounds and methods of making and using the same.Peropyrene compounds, as large polycyclic aromatic hydrocarbons (LPAH), comprise structural features that convey unique photophysical properties to such compounds. However, due to difficult preparation and derivatization of such compounds, their utility has yet to be utilized in various applications. Perylenediimide derivatives, which ...

PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS

The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers. 34-. (canceled)8. (canceled)1723-. (canceled) This application claims benefit under 35 U.S.C. § 119(e) to U.S. Provisional Application No. 63/115,723, filed Nov. 19, 2020, which is hereby incorporated herein by reference in its entirety for all purposes.The present disclosure relates to methods and intermediates for the synthesis of certain compounds which inhibit MCL1, for use in the treatment of cancers.Apoptosis (programmed cell death) is a process for elimination of unwanted or potentially dangerous cells from an organism. Avoidance of apoptosis is critical for the development and sustained growth of tumors. Myeloid cell leukemia 1 protein (MCL1) is an antiapoptotic member of the Bcl-2 family of proteins. MCL1 is overexpressed in many cancers. Overexpression of MCL1 prevents cancer cells from undergoing apoptosis. Research has shown that MCL1 inhibitors can be used to treat cancers. Compounds that inhibit MCL1 have been disclosed, but there remains a need for synthetic methods for preparing such compounds on a manufacturing scale.PCT Application No. PCT/US2019/032053 (Publication No. WO 2019/222112) discloses novel compounds useful as MCL1 inhibitors. This patent publication discloses that compounds according to Formula (I):and pharmaceutically acceptable salts thereof, are effective as inhibitors of MCL1, and are useful in the treatment of cancers. Each of R, R, R, R, Rand Rare as defined in PCT/US2019/032053.There is currently a need for synthetic methods and intermediates that can be used to prepare the compound of Formula (I) and salts thereof. There is also a need for methods for preparing intermediate compounds that can be used to prepare the compound of formula I and salts thereof.In one embodiment, the present disclosure provides a method for preparing a compound Me OMeIn one embodiment, the present ...

NITRATED HYDROCARBONS, DERIVATIVES, AND PROCESSES FOR THEIR MANUFACTURE

Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications. 2. The compound of selected from formula I-1.3. The compound of claim 2 , wherein Rand Rare unsubstituted.4. The compound of claim 2 , wherein the compound is selected from the group consisting of 3-nitrodecane claim 2 , 4-nitrodecane claim 2 , 5-nitrodecane claim 2 , 4-nitrotridecane claim 2 , 5-nitrotridecane claim 2 , 7-nitrotridecane claim 2 , 2-nitrotetradecane claim 2 , 3-nitrotetradecane claim 2 , 4-nitrotetradecane claim 2 , 5-nitrotetradecane claim 2 , 6-nitrotetradecane claim 2 , 7-nitrotetradecane claim 2 , 2-nitropentadecane claim 2 , 3-nitropentadecane claim 2 , 4-nitropentadecane claim 2 , 5-nitropentadecane claim 2 , 6-nitropentadecane claim 2 , 7-nitropentadecane claim 2 , 8-nitropentadecane claim 2 , 3-nitrohexadecane claim 2 , 4-nitrohexadecane claim 2 , 5-nitrohexadecane claim 2 , 6-nitrohexadecane claim 2 , 7-nitrohexadecane claim 2 , 8-nitrohexadecane claim 2 , 2-nitroheptadecane claim 2 , 3-nitroheptadecane claim 2 , 4-nitroheptadecane claim 2 , 5-nitroheptadecane claim 2 , 6-nitroheptadecane claim 2 , 7-nitroheptadecane claim 2 , 8-nitroheptadecane claim 2 , 9-nitroheptadecane claim 2 , 3-nitrooctadecane claim 2 , 4-nitrooctadecane claim 2 , 5-nitrooctadecane claim 2 , 6-nitrooctadecane claim 2 , 7-nitrooctadecane claim 2 , 8-nitrooctadecane claim 2 , and 9-nitrooctadecane.5. The compound of selected from formula II-1.6. The compound of claim 5 , wherein Ris a linear C-Calkyl; and Ris H claim 5 , linear C-Calkyl claim 5 , or CHOH.7. The compound of claim 5 , wherein Ris H or linear C-Calkyl claim 5 , and the total number of carbons in Rand R claim 5 , together with the carbon to which they are ...

REACTIVE IONIC LIQUID, AND ION-IMMOBILIZED METAL OXIDE PARTICLE, ION-IMMOBILIZED ELASTOMER, AND TRANSDUCER USING SAME

A reactive ionic liquid to be used as an ionic component that is contained in an ion-containing layer in a transducer arranged in contact with a high-resistance layer as a dielectric layer of the transducer, and is restrained from migrating from the ion-containing layer to the high-resistance layer on application of a voltage is provided. The reactive ionic liquid comprises an ion pair that consists of an anion and a cation. (a) The cation (a1) is an imidazolium or quaternary ammonium cation, and (a2) comprises a reactive group that consists of an alkoxysilyl or phosphonate group. (b) The anion (b1) is a sulfonate, sulfonylimide, or nitrobenzoate anion. 1. A reactive ionic liquid comprising an ion pair that consists of an anion and a cation , (a1) being an imidazolium or quaternary ammonium cation; and', '(a2) comprising a reactive group that consists of an alkoxysilyl or phosphonate group,, '(a) the cation '(b1) being a sulfonate or nitrobenzoate anion.', '(b) the anion3. An ion-immobilized metal oxide particle comprising:{'claim-ref': {'@idref': 'CLM-00002', 'claim 2'}, 'the cation of the reactive ionic liquid according to ; and'}a metal oxide particle comprising a hydroxyl group,the cation being immobilized to the metal oxide particle via an Si—O or P—O bond between the reactive group of the cation and the hydroxyl group of the metal oxide particle.4. An ion-immobilized elastomer comprising:{'claim-ref': {'@idref': 'CLM-00003', 'claim 3'}, 'the ion-immobilized metal oxide particle according to ; and'}an elastomer that comprises a functional group that is reactive with a hydroxyl group,the ion-immobilized metal oxide particle being immobilized to the elastomer via a bond between a hydroxyl group contained in the ion-immobilized metal oxide particle and the functional group contained in the elastomer.5. A transducer comprising:{'sup': '13', 'a high-resistance dielectric layer that comprises an elastomer and has a volume resistivity of 10Ω·cm or higher;'}a pair of ...

FUNCTIONALIZED ASPHALTENES AND METHODS THEREOF

A functionalized asphaltene, obtained by refluxing with an acid solution. The functionalized asphaltene contains elevated levels of oxygen content due to nitration and oxidation of the refluxing process. The refluxing process also imparts organic functional groups including at least amines, nitro groups carbonyl groups, carboxylic groups and hydroxyl groups to the functionalized asphaltene, and these functional groups are attached to, thereby coating the surface of a functionalized asphaltene particle. A method for removing dye compounds from an aqueous sample with the functionalized asphaltene is also described. 1. A functionalized asphaltene , comprising:10-35% by weight of elemental oxygen per total weight of the functionalized asphaltene;3-10% by weight of elemental nitrogen per total weight of the functionalized asphaltene; and3-10% by weight of elemental sulfur per total weight of the functionalized asphaltene;wherein the functionalized asphaltene is obtained by refluxing a petroleum asphaltene with an acid, andwherein the functionalized asphaltene has at least one active group selected from the group consisting of an amine group, a nitro group, a carbonyl group, a carboxylic group and a hydroxyl group covalently bonded to an asphaltene core.2. The functionalized asphaltene of claim 1 , having an average particle size of 10-20 nm.3. The functionalized asphaltene of claim 1 , having a particle size distribution of 0.5-100 nm wherein at least 60% of the particles have a particle size of 10-20 nm.4. The functionalized asphaltene of claim 1 , having a specific surface area of no higher than 10 m/g.5. The functionalized asphaltene of claim 1 , having an adsorption average pore width of 1-10 nm.6. A process for preparing the functionalized asphaltene of claim 1 , comprising:refluxing an asphaltene-acid suspension at 70-90° C. for 1-2 h to form the functionalized asphaltene;wherein the asphaltene-acid solution comprises the petroleum asphaltene and the acid.7. The ...

MATERIAL FOR FORMING FILM FOR LITHOGRAPHY, COMPOSITION FOR FORMING FILM FOR LITHOGRAPHY, FILM FOR LITHOGRAPHY, PATTERN FORMING METHOD AND PURIFICATION METHOD

The material for forming a film for lithography according to the present invention contains a compound represented by the following formula (1): 2. The material for forming the film for lithography according to claim 1 , wherein at least one p is an integer of 1 to 4.3. The material for forming the film for lithography according to claim 1 , wherein at least one Rrepresents the monovalent group having the oxygen atom.7. The resin according to claim 6 , wherein at least one p is an integer of 1 to 4.8. The resin according to claim 6 , wherein at least one Rrepresents the monovalent group having the oxygen atom.9. The resin according to claim 6 , wherein the compound having crosslinking reactivity is an aldehyde claim 6 , a ketone claim 6 , a carboxylic acid claim 6 , a carboxylic acid halide claim 6 , a halogen-containing compound claim 6 , an amino compound claim 6 , an imino compound claim 6 , an isocyanate claim 6 , or an unsaturated hydrocarbon group-containing compound.10. The resin according to claim 6 , which is at least one selected from the group consisting of a novolac-based resin claim 6 , an aralkyl-based resin claim 6 , a hydroxystyrene-based resin claim 6 , a (meth)acrylic acid-based resin and copolymers thereof.13. A material for forming a film for lithography claim 6 , comprising the resin according to .14. A composition for forming a film for lithography claim 6 , comprising{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the material for forming the film for lithography according to , and'}an organic solvent.15. The composition for forming the film for lithography according to claim 14 , further comprising an acid generating agent.16. The composition for forming the film for lithography according to claim 14 , further comprising a crosslinking agent.17. A film for lithography claim 14 , formed using the composition for forming the film for lithography according to .18. A resist pattern forming method claim 14 , comprising{'claim-ref': {'@idref': ' ...

METHOD OF PURIFYING NITRATED AROMATIC COMPOUNDS FROM A NITRATION PROCESS

A process for removing impurities from crude nitrated aromatic products obtained during the nitration of aromatic compounds. The nitrated aromatic products are purified by treatment with ammonia washing followed by caustic washing. The nitrophenolic-containing wash waters are treated to recover dissolved organics and ammonia, and the stripped ammonia-wash effluent is incinerated. Carbon dioxide, which can accumulate in the process, is purged to the caustic washer. 1. A method of purifying a nitroaromatic product containing nitro-hydroxy-aromatic by-products produced in a nitration process , comprising the steps of:(a) washing the nitrated aromatic product containing nitro-hydroxy-aromatic by-products with an alkaline aqueous solution comprising ammonia to convert some of the nitro-hydroxy-aromatic by-products into their respective nitro-hydroxy-aromatic ammonium salts;(b) separating an aqueous wash stream containing the nitro-hydroxy-aromatic ammonium salts formed in step (a) from an organic stream comprising ammonia-washed nitroaromatic product;(c) washing the ammonia-washed nitroaromatic product with an aqueous alkali metal hydroxide solution to convert the nitro-hydroxy-aromatic by-products that were not removed in steps (a) and (b) into their respective nitro-hydroxy-aromatic alkali-metal salts; and(d) separating an aqueous wash stream comprising the nitro-hydroxy-aromatic alkali-metal salts produced in step (c) from an organic stream comprising alkali-metal-hydroxide-washed nitroaromatic product.2. A method according to claim 1 , further comprising the step of stripping or concentrating the aqueous wash stream of step (b) to produce a condensate stream comprising nitroaromatic product and ammonia and a stripped effluent stream.3. A method according to claim 2 , further comprising the step of recycling the condensate stream to the ammonia washing of step (a).4. A method according to claim 2 , further comprising the step of treating the stripped effluent stream ...

ZEOLITIC ADSORBENTS WITH LARGE EXTERNAL SURFACE AREA, PROCESS FOR PREPARING THEM AND USES THEREOF

The present invention relates to zeolitic adsorbents based on agglomerated crystals of FAU zeolite containing barium and/or potassium, with large external surface area, combining optimum properties in terms of selectivity and mechanical strength. These adsorbents find applications in the separation of cuts of C8-aromatic isomers and notably of xylenes, in the separation of isomers of substituted toluene such as nitrotoluene, diethyltoluene, toluenediamine, in the separation of cresols, and in the separation of polyhydric alcohols such as sugars. 1. A method for separating para-xylene from cuts of aromatic isomers with 8 carbon atoms , using , as an agent for adsorption of para-xylene , a zeolitic adsorbent comprising at least one FAU zeolite and comprising at least one of barium and potassium , wherein the external surface area of said zeolitic adsorbent , measured by nitrogen adsorption , is greater than 20 m·g , said method comprising:contacting aromatic isomers with 8 carbon atoms with said zeolitic adsorbent; andadsorbing para-xylene.2. A method according to claim 1 , wherein the method is in the liquid phase claim 1 , and wherein adsorbing para-xylene is performed in the presence of a desorbent.3. A method according to claim 2 , wherein the desorbent is selected from the group consisting of toluene and para-diethylbenzene.4. A method according to claim 1 , wherein the method is a simulated moving-bed method.5. A method according to claim 1 , wherein the method is a simulated countercurrent moving-bed method.6. A method according to claim 1 , wherein the zeolitic adsorbent has a content of barium oxide (BaO) above 10% relative to the total weight of the zeolitic adsorbent and a barium content between 23% and 42% claim 1 , inclusive claim 1 , by weight relative to the total weight of the zeolitic adsorbent.7. A method according to claim 1 , wherein the zeolitic adsorbent has a content of potassium oxide KO below 25% by weight relative to the total weight of the ...

APPARATUS AND METHOD FOR CONTINUOUS PRODUCTION OF POLYETHYLENE GLYCOL DINITRATE

A reaction apparatus for producing polyethylene glycol dinitrate (PEGDN) in a continuous manner includes a series of reaction cells spatially disposed in one or more planar structures and a separation arrangement for separating PEGDN and Ammonium Nitrate, in a continuous manner. The separation arrangement is a thin film evaporator and/or falling film evaporator. The plurality of reaction cells includes a feed preparation section having feedstreams for continuously providing an acid composition and a glycol composition to reaction cells. The plurality of reaction cells further includes a nitration section, where the acid composition and the glycol composition react to generate a reaction composition, and a quench and neutralization section, having feed for cooling arrangement and a plurality of feeds for providing an alkaline composition to at least partially neutralize reaction composition. The acid composition includes a mixture of dilute nitric acid and concentrated sulphuric acid. 1. A reaction apparatus for producing polyethylene glycol dinitrate (PEGDN) in a continuous manner , wherein the reaction apparatus comprises: a feed preparation section having feedstreams for continuously providing an acid composition and a glycol composition to reaction cells thereof, wherein the acid composition includes a mixture of dilute nitric acid and concentrated sulphuric acid,', 'a nitration section in which the acid composition and the glycol composition react in reaction cells in a continuous manner to generate a reaction composition, and', 'a quench and neutralization section having a feed for a cooling arrangement for cooling reaction cells to avoid spatial reaction hotspots and thereby preventing thermal runaway occurring within the reaction apparatus, and a plurality of feeds for providing an alkaline composition to at least partially neutralize the reaction composition to cause at least a portion of the polyethylene glycol dinitrate to deposit from a solution of the ...

PREPARATION OF CYCLIC ALLYLIC NITRO COMPOUNDS

Amine-catalyzed formation of cyclic allylic nitro compounds via nitro-aldol reaction is disclosed. A greener solvent and a cheaper, more robust catalyst than in previous reports are used in the nitro-aldol reaction. After screening a range of catalysts the reaction is developed as a selective method of synthesis of α-dehydroherbac and the scope is demonstrated with a small collection of additional substrates. 2. The method of claim 1 , wherein the C-Calkyl acetate is ethyl acetate or isopropyl acetate.4. The method of claim 1 , wherein the amount of the nitroalkane is 1 to 10 equivalents claim 1 , and the amount of the amine catalyst is 0.1 to 1 equivalents claim 1 , both relative to the cyclic ketone.5. The method of claim 1 , wherein the nitro-aldol reaction is conducted under reflux and water is removed.6. The method of claim 5 , wherein a Dean-Stark device or a molecular sieve is used to remove water.7. The method of claim 1 , wherein the reaction product is isolated by distillation.8. The method of claim 7 , wherein an acid wash is conducted prior to distillation.9. The method of claim 1 , wherein the amine catalyst is added portion-wise claim 1 , and the reaction time is 24 hours or less.11. The method of claim 10 , wherein the cyclic allylic nitro compound is 5 claim 10 ,5-dimethyl-1-(1-nitroethyl)cyclohex-1-ene claim 10 , the cyclic ketone is 3 claim 10 ,3-dimethylcyclohexanone claim 10 , and the nitroalkane is nitroethane.12. A method of preparing α-dehydroherbac claim 10 , comprising (a) obtaining 5 claim 10 ,5-dimethyl-1-(1-nitroethyl)cyclohex-1-ene according to the method of claim 10 , (b) a Nef reaction of 5 claim 10 ,5-dimethyl-1-(1-nitroethyl)cyclohex-1-ene to obtain α-dehydroherbac.13. The method of claim 12 , wherein the Nef reaction comprises nitronate salt formation with NaOH claim 12 , followed by treatment with sulfuric acid claim 12 , hydrochloric acid claim 12 , or both.14. A method of preparing Galbascone claim 11 , comprising (c) obtaining ...

NEUROACTIVE SUBSTITUTED CYCLOPENTA[b]PHENANTHRENES AS MODULATORS FOR GABA TYPE-A RECEPTORS

The present disclosure is generally directed to neuroactive substituted cyclopenta[b]phenanthrenes as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.

Process for producing nitrobenzene

The present invention relates to a process for the continuous production of nitrobenzene by the nitration of benzene with nitric acid and sulphuric acid under adiabatic conditions, not the entire production plant being shut down during a production stop, but the production plant being entirely or at least partly operated in recirculation mode. The invention further relates to a plant for producing nitrobenzene and to a method for operating a plant for producing nitrobenzene.

Novel antibiotics

Novel aryl compounds or pharmaceutically acceptable salts thereof, and uses of the same for the treatment of Gram-negative infections.

NOVEL PROCESS FOR PREPARING PHENYLCYCLOPROPYLAMINE DERIVATIVES USING NOVEL INTERMEDIATES

Provided herein is a novel process for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity. 2. The process of claim 1 , wherein the halogen atom in the compounds of formulae II claim 1 , III claim 1 , IV claim 1 , V claim 1 , VI and VII is F; and wherein the leaving group ‘X’ in the compound of formula VIII is Cl.3. The process of claim 1 , wherein the R claim 1 , Rand Rin the compounds of formulae II claim 1 , III claim 1 , IV claim 1 , V claim 1 , VI and VII are H claim 1 , and wherein the Rand Rare F.4. The process of claim 1 , wherein the first solvent used in step-(a) is selected from the group consisting of an aliphatic or alicyclic hydrocarbon claim 1 , a chlorinated aliphatic or aromatic hydrocarbon claim 1 , an aromatic mono or dinitro hydrocarbon claim 1 , and mixtures thereof; wherein the second solvent used in step-(b) is selected from the group consisting of a ketone claim 1 , an aliphatic amide claim 1 , a nitrile claim 1 , a hydrocarbon claim 1 , a cyclic ether claim 1 , an aliphatic ether claim 1 , a polar aprotic solvent claim 1 , and mixtures thereof; wherein the third solvent used in step-(c) is selected from the group consisting of a hydrocarbon claim 1 , a cyclic ether claim 1 , an aliphatic ether claim 1 , a chlorinated hydrocarbon claim 1 , and mixtures thereof; wherein the fourth solvent used in step-(d) is selected from the group consisting of a hydrocarbon claim 1 , cyclic ethers claim 1 , an ether claim 1 , an ester claim 1 , a nitrile claim 1 , an aliphatic amide claim 1 , a chlorinated hydrocarbon claim 1 ...

ARYL COMPOUNDS AND POLYMERS AND METHODS OF MAKING AND USING THE SAME

Disclosed herein are embodiments of aryl compounds and polymers thereof that are made using methods that do not require harsh conditions or expensive reagents. The methods disclosed herein utilize precursor compounds that can be polymerized to form polycyclic aromatic hydrocarbons and polymers, such as carbon-based polymers like nanostructures (e.g., graphene or graphene-like nanoribbons). 3. The compound of claim 1 , wherein the Rgroup is substituted with one or more functional groups selected from aliphatic claim 1 , alkoxy claim 1 , amine claim 1 , thioether claim 1 , haloalkyl claim 1 , nitro claim 1 , halo claim 1 , silyl claim 1 , cycloaliphatic claim 1 , or aryl claim 1 , wherein the one or more functional groups are located meta claim 1 , ortho claim 1 , para claim 1 , or combinations thereof claim 1 , relative to a position at which the Rgroup is attached.4. The compound of claim 1 , wherein each Rgroup independently is substituted with a functional group that is para relative to a position at which the Rgroup is attached.6. The compound of claim 1 , wherein each Rindependently is hydrogen claim 1 , alkyl claim 1 , or a combination thereof.7. The compound of claim 1 , wherein alkyl is methyl claim 1 , ethyl claim 1 , propyl claim 1 , iso-propyl claim 1 , butyl claim 1 , iso-butyl claim 1 , tert-butyl claim 1 , or combinations thereof.9. The compound of claim 1 , wherein each Rindependently is halogen claim 1 , or an aliphatic group terminated with —SOCHor —SOCF.11. The compound of claim 1 , wherein the compound is axially chiral.13. The method of claim 12 , wherein the boron-containing moiety is a boronic acid or B[—OC(R)C(R)O—] claim 12 , wherein each Rindependently is aliphatic.14. The method of claim 12 , wherein the acid is CFSOH claim 12 , CHSOH claim 12 , or a combination thereof.15. The method of claim 12 , wherein the temperature ranges from −40° C. to ambient temperature.16. The method of claim 12 , wherein the temperature ranges from 0° C. to ...

Additive Composition for Control and Inhibition of Polymerization of Aromatic Vinyl Monomers, and Method of Use Thereof

The present invention relates to an improved additive composition for control and inhibition of polymerization of aromatic vinyl monomers including styrene comprising one or more of aromatic nitro compounds and one or more of aliphatic tertiary amines. In one embodiment, the present invention also relates to method of use of presently provided composition. In another embodiment, the present invention also relates to method of controlling and inhibiting polymerization of aromatic vinyl monomers including styrene by employing presently provided composition. In still another embodiment, the present invention also relates to method of preparation of presently provided composition.

TUNGSTEN OXIDE PRIMER COMPOSITIONS

A primer composition is provided having a primary explosive and an oxidizer system containing at least one tungsten oxide or one tungstate compound. The oxidizer system can by non-hydroscopic and non-toxic. The primer can include reducing agents, sensitizers, binders and gas producing agents. The primer composition generally is applicable to any application or device that employs ignition of a propellant, a fuel, a relay charge, a delay charge, or a booster charge, including, but not limited to, air bag gas generator systems, signaling devices, ejection seats, small, medium or large arms ammunition primers, and the like. 2. A primer composition comprising:a. no more than about 70% by weight of a percussion-sensitive organic primary explosive compound;b. from about 15% to about 50% by weight of a oxidizer;c. from about 5% to about 30% by weight of a reducing agent;d. from 0% to about 30% by weight of a sensitizer;e. from 0% to about 25% by weight of a gas producing agent;f. from 0% to about 20% by weight of a friction agent;g. from 0% to about 10% by weight of a decoppering agent; andh. from 0% to about 20% by weight of a conductive component.3. The primer composition of claim 2 , wherein the percussion-sensitive organic primary explosive compound comprises a compound chosen from salts of trinitroresorcinol claim 2 , dinitrobenzofuroxan (DNBF) claim 2 , potassium dinitrobenzofuroxane (KDNBF) claim 2 , diazodinitrophenol (DDNP) claim 2 , lead azide claim 2 , silver azide claim 2 , salts of fulminate claim 2 , salts of hydrazoic acid claim 2 , salts of 5-nitrotetrazole claim 2 , tetrazene claim 2 , salts of tetrazene claim 2 , salts of amino guanidine claim 2 , salts of cyanamide claim 2 , nitrocyanamide salts claim 2 , nitrophenol salts claim 2 , nitrosophenol salts nitramine salts claim 2 , salts of metazonic acid claim 2 , oxalic salts claim 2 , peroxides claim 2 , acetylide salts claim 2 , nitrogen sulphide claim 2 , nitrogen selenide claim 2 , thiocyanic salts ...

DYE REMOVAL FROM AQUEOUS COMPOSITIONS

A functionalized asphaltene, obtained by refluxing with an acid solution. The functionalized asphaltene contains elevated levels of oxygen content due to nitration and oxidation of the refluxing process. The refluxing process also imparts organic functional groups including at least amines, nitro groups carbonyl groups, carboxylic groups and hydroxyl groups to the functionalized asphaltene, and these functional groups are attached to, thereby coating the surface of a functionalized asphaltene particle. A method for removing dye compounds from an aqueous sample with the functionalized asphaltene is also described. 112-. (canceled)13. A method for treating an aqueous sample to remove a dye compound therefrom , comprising:contacting the aqueous sample with particles of a functionalized asphaltene to adsorb the dye compound onto the particles of the functionalized asphaltene, and thenfiltering the aqueous sample to remove the particles of the functionalized asphaltene having the dye compound adsorbed thereon; 10-35% by weight of elemental oxygen per total weight of the functionalized asphaltene;', '3-10% by weight of elemental nitrogen per total weight of the functionalized asphaltene; and', '3-10% by weight of elemental sulfur per total weight of the functionalized asphaltene;', 'wherein the particles of the functionalized asphaltene are obtained by refluxing a petroleum asphaltene with an acid, and', 'wherein the functionalized asphaltene has at least one active group selected from the group consisting of an amine group, a nitro group, a carbonyl group, a carboxylic group and a hydroxyl group covalently bonded to an asphaltene core., 'wherein the functionalized asphaltene comprises14. The method of claim 13 , wherein the particles of the functionalized asphaltene have an adsorption capacity of 1-5 mg of the dye compound per g of the functionalized asphaltene.15. The method of claim 13 , wherein the aqueous sample is contacted with the particles of the functionalized ...

METHOD AND SYSTEM FOR PRODUCING NITROBENZENE

The present invention relates to a process and a plant for the production, in particular the continuous production, of nitrobenzene by means of adiabatic nitration of benzene with nitric acid in the presence of sulfuric acid, in which, following the nitration, a multi-stage concentration of the sulfuric acid is carried out by means of heating at a pressure that is reduced as compared with ambient pressure, and wherein the heating takes place using the heat generated in the adiabatic nitration of benzene. 2. Process according to claim 1 , characterised in that the product mixture obtained in the nitration has a temperature of at least 120° C.3. Process according to or claim 1 , characterised in that a proportion of at least 90% of the heat for the evaporation according to step ii) comes from the reaction enthalpy of the adiabatic nitration reaction.4. Process according to claim 3 , characterised in that the heat for the evaporation according to step ii) comes solely from the reaction enthalpy of the adiabatic nitration reaction.5. Process according to claim 3 , characterised in that a proportion of up to 10% of the heat used for the evaporation is fed to the two stages from outside the process.6. Process according to any one of the preceding claims claim 3 , characterised in that the feed of spent acid to the first stage according to i) contains from 60 to 75% by mass HSO.7. Process according to any one of the preceding claims claim 3 , characterised in that the steam separated in each stage according to i) is liquefied by condensation.8. Process according to claim 7 , characterised in that the liquefied steam separated off is fed to a phase separator.9. Process according to any one of the preceding claims claim 7 , characterised in that the concentrated sulfuric acid according to step c) claim 7 , after passing through both stages of step i) claim 7 , has a content by mass of HSOof not less than 65%. The present invention relates to a process and a plant for the ...

ARYL ISONITRILES AS A NEW CLASS OF ANTIMICROBIAL COMPOUNDS

The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of 2. The compound of wherein R is methyl claim 1 , n is 1 and X is hydrogen and Y claim 1 , W and Z are —CH—.3. The compound of wherein R is ethyl claim 1 , methyl claim 1 , n-propyl or n-butyl or phenyl.4. The compound of wherein R is hydrogen and n is 0.5. The compound of wherein X is hydrogen and Y claim 4 , W and Z are —CH—.6. The compound of wherein X is —F claim 1 , —CF claim 1 , —OMe claim 1 , -n-butyl or —NO.7. The compound of wherein X is in the para position.8. A method for inhibiting MRSA comprising contacting MRSA with the compound of .10. The method of wherein R is hydrogen and n is 0.11. The method of wherein X is hydrogen and Y claim 10 , W and Z are —CH—.12. The method of wherein the amount the isonitrile compound is from about 50 μM to about 100 μM.13. The method of wherein the strain of MRSA is NRS1 claim 9 , NRS72 claim 9 , NRS119 claim 9 , NRS382 claim 9 , NRS383 claim 9 , NRS384 claim 9 , NRS385 claim 9 , NRS386 claim 9 , VRS2 or combinations thereof.14. Treatment of a patient with MRSA with the method of .16. The method of wherein R is hydrogen and n is 0.17. The method of wherein X is hydrogen and Y claim 16 , W and Z are —CH—.18. The method of wherein the strain of MRSA is NRS1 claim 15 , NRS72 claim 15 , NRS119 claim 15 , NRS382 claim 15 , NRS383 claim 15 , NRS384 claim 15 , NRS385 claim 15 , NRS386 claim 15 , VRS2 or combinations thereof.19. The method of wherein the isonitrile compound is administered with a second antibacterial compound. This invention is directed generally to new antimicrobial compounds and more specifically, to aryl isonitrile compounds as a new class of antimicrobial compounds.Multidrug-resistant bacterial infections pose a significant global health challenge afflicting more than 2 million people each year ...

MODIFIED GRAPHENE, METHOD OF PRODUCING MODIFIED GRAPHENE, MODIFIED GRAPHENE-RESIN COMPOSITE, MODIFIED GRAPHENE SHEET, AND MODIFIED GRAPHENE DISPERSION

The modified graphene includes a structure represented by the following formula (I), wherein the modified graphene has a ratio (g/d) of an intensity “g” of a G band to an intensity “d” of a D band of 1.0 or more in a Raman spectroscopy spectrum thereof: 2. The modified graphene according to claim 1 , wherein in the formula (I) claim 1 , the Ar1 represents a phenylene group claim 1 , a biphenylene group claim 1 , a triphenylene group claim 1 , or a naphthalene group claim 1 , the X1 represents a single bond claim 1 , the Y1 represents a carboxylic acid group claim 1 , and the n1 represents from 1 to 6.4. The modified graphene according to claim 1 , wherein in the formula (I) claim 1 , the Ar1 represents a phenylene group claim 1 , the X1 represents a single bond claim 1 , the Y1 represents a nitro group claim 1 , and the n1 represents from 1 to 3.7. The modified graphene according to claim 1 , wherein when the Y1 in the formula (I) represents a group claim 1 , a number of moles of the group with respect to 1 g of the modified graphene is 0.10 mmol or more.8. The modified graphene according to claim 7 , wherein when the Y1 in the formula (I) represents a group claim 7 , the number of moles of the group with respect to 1 g of the modified graphene is 0.10 mmol or more and 1.20 mmol or less.10. The method of producing a modified graphene according to claim 9 , further comprising producing the compound represented by the formula (V) through abstraction of a hydrogen atom from a compound represented by the following formula (VI):{'br': None, 'sub': '2', 'HN—NH-A1\u2003\u2003(VI)'}in the formula (VI), A1 is the same as the A1 in the formula (V).11. The method of producing a modified graphene according to claim 10 , further comprising producing the compound represented by the formula (V) through use of at least one ofa compound in which in the A1, the Ar1 represents a phenylene group, the X1 represents a single bond, and the Y1 represents a carboxylic acid group, ora ...

Process for the preparation of organic halides

The present invention provides a halo-de-carboxylation process for the preparation of organic chlorides, organic bromides and mixtures thereof, from their corresponding carboxylic acids, using a chlorinating agent selected from trichloroisocyanuric acid (TCCA), dichloroisocyanuric acid (DCCA), or combination thereof, and a brominating agent.

Thionyl tetrafluoride modified compounds and uses

Thionyl tetrafluoride gas reacts efficiently with primary amines to form reactive iminosulfur oxydifluoride compounds. These dual S VI —F loaded iminosulfur oxydifluoride compounds, in turn, readily react with secondary amines or aryloxy silyl ethers (ArO—SiR 3 ), yielding the corresponding fused heteroatom-linked substrates. Iminosulfur oxyfluoride polymers also are provided by disclosed methods.

METHOD FOR CONTINUOUSLY PRODUCING A PRODUCT BY WAY OF AT LEAST TWO COUPLED-TOGETHER CHEMICAL REACTIONS

A method for continuously producing a product (A) by way of at least two coupled-together chemical reactions (C, C), wherein at least two input substances (E, E) are fed to a first chemical reaction (C), wherein a plurality of intermediate substances (Z, Z) are produced from the input substances (E, E) by the first chemical reaction (C), wherein at least one of the intermediate substances (Z) is fed to a second chemical reaction (C), wherein the at least one fed intermediate substance (Z) is further processed by the second chemical reaction (C), in particular using at least one further substance (W, W) in a second chemical reaction (C) to form a plurality of output substances (A, A), that is to say to form the chemical product (A) and at least one further output substance (A), wherein the flow rates (F) of the fed substances (E, E, Z, W, W, A) that are fed to one of the reactions (C, C) are set by a respective actuating element (V, V, V, V, V, V), wherein each of the fed substances is assigned a separate actuating element, wherein a manipulated variable (S, S) that is stipulated by a controller (R, R) is respectively applied to at least one of the actuating elements, wherein, for changing the production rate of the chemical product (A1), a temporary manipulated variable (S, S) is respectively applied during a transient phase (II, III) to at least one of these actuating elements (V, V) instead of the manipulated variables (S, S) stipulated by the respective controllers (R, R), wherein the temporary manipulated variable (S, S) or the temporary manipulated variables is/are generated by at least one control unit (SE) in dependence on a default value (NV). 1112. A process for the continuous production of a product (A) via at least two coupled chemical reactions (C , C) , comprising{'b': 1', '2', '1, 'feeding at least two starting materials comprising a first starting material (E) and a second starting material (E), to a first chemical reaction (C),'}{'b': 1', '2', '1', ' ...

METHOD FOR CONTINUOUSLY PRODUCING A PRODUCT BY WAY OF AT LEAST TWO COUPLED-TOGETHER CHEMICAL REACTIONS

A method for continuously producing a product (A) by way of at least two coupled-together chemical reactions (C C), wherein at least two input substances (E E) are fed to a first chemical reaction (C), wherein a plurality of intermediate substances (Z Z) are produced from the input substances (E E) by the first chemical reaction (C), wherein at least one of the intermediate substances (Z) is fed to a second chemical reaction (C), wherein the at least one fed intermediate substance (Z) is further processed by the second chemical reaction (C), in particular using at least one further substance (W W) in a second chemical reaction (C) to form a plurality of output substances (A A), that is to say to form the chemical product (A) and at least one further output substance (A), wherein the flow rates (F) of the fed substances (E E, Z W W, A) that are fed to one of the reactions (C C) are set by a respective actuating element (V, V, V, V, V, V), wherein each of the fed substances is assigned a separate actuating element, wherein a manipulated variable (S, S) that is stipulated by a controller (R, R) is respectively applied to at least one of the actuating elements, wherein, for changing the production rate of the chemical product (A), a temporary manipulated variable (S, S) is respectively applied during a transient phase (II, III) to at least one of these actuating elements (V, V) instead of the manipulated variables (S, S) stipulated by the respective controllers (R, R), wherein the temporary manipulated variable (S, S) or the temporary manipulated variables is/are generated by at least one control unit (SE) in dependence on a default value (NV). 1112121121212222121212121122121. A process for the continuous production of a product (A) via at least two coupled chemical reactions (C , C) , comprising feeding at least two starting materials (E , E) to a first chemical reaction (C) thereby producing a plurality of intermediates (Z , Z) from the starting materials (E , E) by ...

NITRATED HYDROCARBONS, DERIVATIVES, AND PROCESSES FOR THEIR MANUFACTURE

Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications. 2. The compound of selected from formula I-1.3. The compound of claim 2 , wherein Rand Rare unsubstituted.4. The compound of claim 2 , wherein the compound is selected from the group consisting of 3-nitrodecane claim 2 , 4-nitrodecane claim 2 , 5-nitrodecane claim 2 , 4-nitrotridecane claim 2 , 5-nitrotridecane claim 2 , 7-nitrotridecane claim 2 , 2-nitrotetradecane claim 2 , 3-nitrotetradecane claim 2 , 4-nitrotetradecane claim 2 , 5-nitrotetradecane claim 2 , 6-nitrotetradecane claim 2 , 7-nitrotetradecane claim 2 , 2-nitropentadecane claim 2 , 3-nitropentadecane claim 2 , 4-nitropentadecane claim 2 , 5-nitropentadecane claim 2 , 6-nitropentadecane claim 2 , 7-nitropentadecane claim 2 , 8-nitropentadecane claim 2 , 3-nitrohexadecane claim 2 , 4-nitrohexadecane claim 2 , 5-nitrohexadecane claim 2 , 6-nitrohexadecane claim 2 , 7-nitrohexadecane claim 2 , 8-nitrohexadecane claim 2 , 2-nitroheptadecane claim 2 , 3-nitroheptadecane claim 2 , 4-nitroheptadecane claim 2 , 5-nitroheptadecane claim 2 , 6-nitroheptadecane claim 2 , 7-nitroheptadecane claim 2 , 8-nitroheptadecane claim 2 , 9-nitroheptadecane claim 2 , 3-nitrooctadecane claim 2 , 4-nitrooctadecane claim 2 , 5-nitrooctadecane claim 2 , 6-nitrooctadecane claim 2 , 7-nitrooctadecane claim 2 , 8-nitrooctadecane claim 2 , and 9-nitrooctadecane.5. The compound of selected from formula IV-1.6. The compound of claim 5 , wherein Ris linear C-Calkyl claim 5 , C-Ccycloalkyl claim 5 , aryl claim 5 , or aryl-alkyl- claim 5 , and Ris H or C-Calkyl.7. The compound of claim 5 , wherein Ris C-Calkyl.8. The compound of claim 5 , wherein Ris linear C-Calkyl.9. The compound of ...

ARYL COMPOUNDS AND POLYMERS AND METHODS OF MAKING AND USING THE SAME

Disclosed herein are embodiments of aryl compounds and polymers thereof that are made using methods that do not require harsh conditions or expensive reagents. The methods disclosed herein utilize precursor compounds that can be polymerized to form polycyclic aromatic hydrocarbons and polymers, such as carbon-based polymers like nanostructures (e.g., graphene or graphene-like nanoribbons). 3. The compound of claim 1 , wherein the electron-donating group is an alkoxy group.4. The compound of claim 1 , wherein each Rindependently is a heteroaliphatic group including at least one sulfur atom.5. The compound of claim 4 , wherein the heteroaliphatic group including at least one sulfur atom is a thioether.6. The compound of claim 4 , wherein the heteroaliphatic group including at least one sulfur atom is a thiol.8. The compound of claim 7 , wherein each Rindependently is an aryl group substituted with one or more functional groups selected from aliphatic claim 7 , amine claim 7 , or nitro.10. The compound of claim 9 , wherein the electron-donating group is an alkoxy group.11. The compound of claim 7 , wherein each Rindependently is heteroaliphatic group including at least one sulfur atom.12. The compound of claim 11 , wherein the heteroaliphatic group including at least one sulfur atom is a thioether.13. The compound of claim 11 , wherein the heteroaliphatic group including at least one sulfur atom is a thiol.15. The compound of claim 14 , wherein the disulfide is —CHSSH claim 14 , —CHCHSSH claim 14 , or —SCHCHSSH.16. The compound of claim 14 , wherein the thiol is —CHSH claim 14 , —CHCHSH claim 14 , or —SCHCHSH.17. The compound of claim 14 , wherein the thioether is —SCH claim 14 , —CHSCH claim 14 , —CHCHSCH claim 14 , or —SCHCHSCH. This application is a continuation of U.S. application Ser. No. 15/558,978, filed on Sep. 15, 2017, which is the U.S. National Stage of International Application No. PCT/US2016/023179, filed Mar. 18, 2016, which was published in English under ...

METHODS AND MEDICAL USES

There is provided a method of treatment of hypersomnolence comprising administering the steroidal compound 3α-ethynyl-3β-hydroxy-5α-androstan-17-one oxime, or a pharmaceutically acceptable salt thereof, to a subject in need of such treatment. 2. The method as claimed in claim 1 , wherein the hypersomnolence is GABAreceptor-mediated hypersomnia.3. The method as claimed in claim 1 , wherein the hypersomnolence is primary hypersomnia.4. The method as claimed in claim 1 , wherein the hypersomnolence is secondary hypersomnia.5. The method as claimed in claim 1 , wherein the hypersomnolence is a disorder selected from the group consisting of idiopathic hypersomnia claim 1 , recurrent hypersomnia claim 1 , narcolepsy claim 1 , shift work sleeping disorder claim 1 , excessive sleepiness claim 1 , endozepine-related recurrent stupor and amphetamine-resistant hypersomnia.6. The method as claimed in claim 5 , wherein the hypersomnolence disorder is idiopathic hypersomnia.7. The method as claimed in claim 5 , wherein the hypersomnolence disorder is type 2 narcolepsy.8. The method as claimed in claim 5 , wherein the hypersomnolence disorder is type 1 narcolepsy.9. The method as claimed in claim 1 , wherein the hypersomnolence is related to a disorder selected from the group consisting of restless leg syndrome claim 1 , nocturnal dystonia claim 1 , nocturnal movement disorder claim 1 , Klein-Levin syndrome claim 1 , Parkinson's disease claim 1 , a disorder related to a medication or substance claim 1 , a psychiatric disorder claim 1 , rapid eye movement (REM) behaviour disorder claim 1 , frontal nocturnal dystonia claim 1 , nocturnal movement disorder claim 1 , obstructive sleep apnoea claim 1 , liver cirrhosis and hepatic encephalopathy.10. A method of promoting wakefulness comprising administering an effective amount of 3α-ethynyl-3β-hydroxy-5α-androstan-17-one oxime claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , to a subject in need of such treatment.11. The ...

PROCESS FOR PRODUCING NITROBENZENE

The present invention relates to a process for the continuous production of nitrobenzene by the nitration of benzene with nitric acid and sulphuric acid under adiabatic conditions, not the entire production plant being shut down during a production stop, but the production plant being entirely or at least partly operated in recirculation mode. The invention further relates to a plant for producing nitrobenzene and to a method for operating a plant for producing nitrobenzene. 1. A process , preferably operated adiabatically , for preparing nitrobenzene , comprising the steps of{'sub': 1', '2', '3, '(I) nitrating benzene with nitric acid in sulfuric acid to form nitrobenzene in a reactor, with introduction of benzene with a mass flow rate of m, nitric acid with a mass flow rate of mand sulfuric acid with a mass flow rate of minto the reactor;'}(II) separating the phases of the reaction mixture from step (I) in a phase separation apparatus into an aqueous sulfuric acid-containing phase and an organic nitrobenzene-containing phase; and optionally (and preferably) steps (III) to (V):{'sub': '3', '(III) concentrating the aqueous phase obtained in step (II) by evaporating water in an evaporation apparatus to give an aqueous sulfuric acid-containing phase having elevated sulfuric acid concentration, with recycling of the concentrated sulfuric acid-containing aqueous phase via a sulfuric acid tank into step (I) and use thereof as a constituent of mass flow m;'}(IV) washing the organic nitrobenzene-containing phase obtained in step (II) in at least two stages and separating off the aqueous phase after each stage, using a wash vessel having a phase separation unit or a wash vessel and a separate phase separation apparatus in each stage,(V) distilling, preferably rectifying, the organic nitrobenzene-containing phase obtained in the last stage of step (IV) in a distillation apparatus, and(VI) working up the wastewater from the first wash stage of step (IV), comprising collecting ...

Phenoxymethyl derivatives

wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.

AMINOADAMANTYL NITRATE COMPOUNDS AND THEIR USE TO TREAT CNS DISORDERS

The present disclosure provides adamantyl compounds having one or more amine groups and one or more nitrate groups. The aminoadamantyl nitrate compounds can be used to treat disorders of the central nervous system, including neurodegenerative and non-neurodegenerative diseases. 3. The compound of claim 2 , wherein n is 1 claim 2 , Ris a methyl claim 2 , Ris a methyl claim 2 , X is a —(CH)— claim 2 , and Y is a ONO.4. The compound of claim 2 , wherein n is 2 claim 2 , R is a methyl claim 2 , Ris a methyl claim 2 , X is a propyl group claim 2 , and Y is a ONO.5. The compound of claim 2 , wherein n is 1 claim 2 , R is a methyl claim 2 , Ris a methyl claim 2 , X is a bond claim 2 , and Y is a ONO.8. The compound of claim 2 , claim 2 , or claim 2 , wherein X of the compound of the Formula I claim 2 , Ia claim 2 , IA claim 2 , or IAa is a bond claim 2 , a linear or a branched C-Cor C-C-alkyl- claim 2 , or a linear or a branched C-Cor C-C—O-alkyl-.13. The compound of claim 12 , wherein p is 1 claim 12 , X is a bond claim 12 , and Y is an ortho —ONO.14. The compound of claim 12 , wherein p is 1 claim 12 , X is an ortho O—(CH)— claim 12 , and Y is an ortho —ONO.20. The compound of any one of claim 12 , claim 12 , claim 12 , claim 12 , claim 12 , claim 12 , claim 12 , or wherein X is a bond claim 12 , a linear or a branched C-Cor C-C-alkyl- claim 12 , or a linear or a branched C-Cor C-C—O-alkyl. The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR) is an excitatory glutamate receptor and ion-channel protein found in neurons in the central nervous system (CNS). Activation of the NMDA receptor requires the binding of glutamate (or aspartate or NMDA, both weaker stimulants), which is released following depolarization of the presynaptic neuron, and the binding of glycine (or D-serine, a stronger co-agonist) for efficient opening of the ion-channel part of the receptor. Activation of the NMDAR produces an excitatory postsynaptic potential that results in the ...

Nitration Of Benzene

The present invention discloses a process for nitration of benzene. More particularly, the present invention discloses an efficient, environmental friendly process for the nitration of benzene using a modified solid acid catalyst. 1. A grafted hydrophobic solid acid WO/SiOcatalyst for nitration of benzene.2. The grafted hydrophobic solid acid catalyst as claimed in claim 1 , wherein the catalyst is post grafted with organosilane selected from C2 to C10 alkyl trialkoxysilane where alkoxy is methoxy claim 1 , ethoxy or propoxy.3. A process for preparing grafted hydrophobic solid acid catalyst of comprising the steps of:{'sub': 3', '2, 'a. dispersing 20% WO/SiOcatalyst is dry tolueneb. adding organosilane selected from alkyl trialkoxysilane to the reaction mixture of step a;c. heating the resultant mixture with constant mixing to obtain a powder from andd. drying the resultant powder oven to obtain grafted hydrophobic solid acid catalyst.4. The process as claimed in claim 3 , wherein the ratio of WO/SiOto dry toluene is 1:4 to 1:20.5. A process for nitration of benzene comprising the steps of:a) charging benzene and a grafted hydrophobic solid acid catalyst in the range of 1:0.1 to 1:1 in a reactor flushed with nitrogen followed by refluxing the reaction mixture at temperature in the range of 90 to 110° C. for the period in the range of 1 to 2 hour andb) adding nitric acid to the reaction mixture of step (a) with constantly removing the water formed by azeotropic distillation followed by refluxing the reaction mixture at temperature in the range of 90 to 110° C. for the period in the range of 6 to 8 hour to afford mononitrobenzene.6. The process as claimed in claim 1 , wherein solid acid catalyst is WO/SiO claim 1 ,7. The process as claimed in claim 2 , wherein said solid acid catalyst is post grafted with organosilanes.8. The process as claimed in claim 1 , wherein conversion of said benzene is in the range of 50 to 100%.9. The process as claimed in claim 1 , wherein ...

Hypergolic co-crystal material and method of use thereof

A hypergolic co-crystal material for producing a hypergol when combined with an oxidizer; it has co-crystals composed at least of a hypergolic trigger component and an energetic coformer.

STORAGE STABLE MIXTURES

The present invention relates to improved formulations of propandiol mononitrate and derivatives thereof as well as to the production of such formulations. 2. The storage stable mixture according to claim 1 , wherein the compound according to formula (I) is propandiol mononitrate.3. The storage stable mixture according to claim 1 , wherein the at least one clay mineral is selected from the group consisting of Bentonite claim 1 , Sepiolite Kaolinite claim 1 , and Montmorillonite claim 1 , preferably from Bentonite and Sepiolite as well as mixtures thereof.4. The storage stable mixture according to claim 1 , wherein the weight-ratio of the mineral clay to the powderous formulation is selected in the range of 100:1 to 1:1 claim 1 , preferably in the range of 40:1 to 1:2 claim 1 , most preferably in the range of 30:1 to 1:1 or 20:1 to 1:1.5. The storage stable mixture according to claim 1 , wherein the powderous formulation consists essentially of(i) 2 to 20 wt-%, based on the total weight of the powderous formulation, of a compound of formula (I), and(iii) at least 25 wt-%, based on the total weight of the powderous formulation, of silica, and(iv) 10 wt-% to 45 wt-%, based on the total weight of the powderous formulation, of an edible oil, and(v) 0 to 10 wt-%, based on the total weight of the powderous formulation, of an additive.6. The storage stable mixture according to claim 5 , wherein the edible oil in the powderous formulation is selected from the group consisting of propyleneglycol claim 5 , canola oil claim 5 , corn oil claim 5 , rapeseed oil claim 5 , sunflower oil claim 5 , middle chain triglyceride (MCT) and glycerol as well as mixtures thereof.7. The storage stable mixture according to claim 5 , wherein the additive is a thickener selected from the group consisting of gums and/ or cellulose derivatives claim 5 , preferably from xanthan gum claim 5 , karaya gum and/or ethylcellulose.8. The storage stable mixture according to claim 5 , wherein the edible oil ...

Bifunctional chiral organocatalytic compound having excellent enantioselectivity, preparation method therefor, and method for producing non-natural gamma-amino acid from nitro compound by using same

The present invention relates to a bifunctional chiral organocatalytic compound having excellent enantioselectivity, a preparation method therefor, and a method for producing a non-natural gamma amino acid from a nitro compound by using the chiral organocatalytic compound. According to the present invention, the bifunctional chiral organocatalytic compound having excellent enantioselectivity can be easily synthesized, gamma-amino acids with high optical selectivity can be obtained at a high yield by an economical and convenient method using the chiral organocatalytic compound, and various (R)-configuration gamma-amino acids, which are not present in nature, can be produced with high optical purity in large quantities by using a small amount of a catalyst, and therefore, the present invention can be widely utilized in various industrial fields including the pharmaceutical industry.

Catalysts containing per-ortho aryl substituted aryl or heteroaryl substituted nitrogen donors

Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising one or two nitrogen donor atom or atoms independently substituted by an aromatic or heteroaromatic ring(s), wherein the ortho positions of said ring(s) are substituted by aryl or heteroaryl groups. Also disclosed are processes for the polymerization of olefins using the catalyst compositions.

Olefin polymerization processes using supported catalysts

Improved Group 8-10 transition metal based supported catalyst processes for the polymerization of olefins are described. Some of the improvements pertain to protocols for catalyst preparation and activation which improve the catalyst productivity in the presence of hydrogen as a molecular weight control agent.

Catalysts containing per-ortho aryl substituted aryl or heteroaryl substituted nitrogen donors

Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising one or two nitrogen donor atom or atoms independently substituted by an aromatic or heteroaromatic ring(s), wherein the ortho positions of said ring(s) are substituted by aryl or heteroaryl groups. Also disclosed are processes for the polymerization of olefins using the catalyst compositions.

Catalysts containing per-ortho aryl substituted aryl or heteroaryl substituted nitrogen donors

Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising one or two nitrogen donor atom or atoms independently substituted by an aromatic or heteroaromatic ring(s), wherein the ortho positions of said ring(s) are substituted by aryl or heteroaryl groups. Also disclosed are processes for the polymerization of olefins using the catalyst compositions.

Catalysts containing per-ortho aryl substituted aryl or heteroaryl substituted nitrogen donors

Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising one or two nitrogen donor atom or atoms independently substituted by an aromatic or heteroaromatic ring(s), wherein the ortho positions of said ring(s) are substituted by aryl or heteroaryl groups. Also disclosed are processes for the polymerization of olefins using the catalyst compositions.

Catalysts containing per-ortho aryl substituted aryl or heteroaryl substituted nitrogen donors

Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising one or two nitrogen donor atom or atoms independently substituted by an aromatic or heteroaromafic ring(s), wherein the ortho positions of said ring(s) are substituted by aryl or heteroaryl groups. Also disclosed are processes for the polymerization of olefins using the catalyst compositions.

Polymerizable higher diamondoid derivatives

Higher diamondoid derivatives capable of taking part in polymerization reactions are disclosed as are intermediates to these derivatives, polymers formed from these derivatives and methods for preparing the polymers.

Processes for the purification of higher diamondoiss and compositions comprising such diamondoids

Processo para a preparação contínua de mononitrotoluenos

Productivity catalysts and microstructure control

Improved Group 3-11 transition metal based catalysts and processes for the polymerization of olefins are described. Some of the ligands are characterized by a preferred substitution pattern which allows for higher productivities of highly branched olefins; substitution patterns which boost productivity or alter the polymer microstructure are also described.

Polymerizable higher diamondoid derivatives

Higher diamondoid derivatives capable of taking part in polymerization reactions are disclosed as well as intermediates to these derivatives, polymers formed from these derivatives and methods for preparing the polymers.

Catalysts containing per-ortho aryl substituted aryl or heteroaryl substituted nitrogen donors

Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising one or two nitrogen donor atom or atoms independently substituted by an aromatic or heteroaromatic ring(s), wherein the ortho positions of said ring(s) are substituted by aryl or heteroaryl groups. Also disclosed are processes for the polymerization of olefins using the catalyst compositions.

Continuous isothermal process for the production of mononitrotoluenes

METHOD FOR PRODUCING DINITROTOLUOL

Synthesis and use of intermetallic iron palladium nanoparticle compositions

An intermetallic magnetic compound of iron oxide and palladium with a nanometer particle size is disclosed, together with a method of making magnetic nanoparticles that include an intermetallic bond between palladium and iron-oxide. Additionally, a method is disclosed of catalyzing an organic reaction by contacting the organic reagents with an intermetallic magnetic compound of iron oxide and palladium that has nanometer particle size in an amount sufficient to catalyze the organic reaction.

Способ получения производных азотистого иприта

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2017 142 725 A (51) МПК C07K 5/065 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2017142725, 06.05.2016 (71) Заявитель(и): ОНКОПЕПТАЙДС АБ (SE) Приоритет(ы): (30) Конвенционный приоритет: 08.05.2015 GB 1507903.1 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 08.12.2017 R U (43) Дата публикации заявки: 10.06.2019 Бюл. № 16 (72) Автор(ы): ВАЛЬСТРЁМ Никлас Хокан (SE), ВЕННЕРБЕРГ Йохан Андерс (SE) (86) Заявка PCT: (87) Публикация заявки PCT: WO 2016/180740 (17.11.2016) A Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, стр. 3, ООО "Юридическая фирма Городисский и Партнеры" (57) Формула изобретения 1. Способ получения соединения (III) или его лишенного защиты продукта: R U A 2 0 1 7 1 4 2 7 2 5 (54) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ АЗОТИСТОГО ИПРИТА 2 0 1 7 1 4 2 7 2 5 EP 2016/060242 (06.05.2016) Стр.: 1 R U A A (II) с хлоруксусной кислотой, в присутствии восстановителя; где PG представляет собой защитную группу, и R представляет собой OH в R U 2 0 1 7 1 4 2 7 2 5 2 0 1 7 1 4 2 7 2 5 (III) включающий взаимодействие соединения (II) Стр.: 2 соответствующим образом защищенной форме или . 2 0 1 7 1 4 2 7 2 5 R U A Стр.: 3 2 0 1 7 1 4 2 7 2 5 A R U 2. Способ по п.1, который осуществляют в присутствии восстановителя, выбранного из группы, состоящей из борана, комплекса боран-основание по Льюису, боргидрида, гидрида металла и Н2, в присутствии металлического катализатора. 3. Способ по п.2, где восстановителем является BH3 или боран-диметилсульфид. 4. Способ по любому из пп.1-3, где PG выбран из группы, состоящей из метилоксикарбонила, этилоксикарбонила, 9-флуоренилметилоксикарбонила, третбутилоксикарбонила, бензилоксикарбонила, p-метоксибензилоксикарбонила, 1адамантилоксикарбонила, p-бромбензилоксикарбонила, трифторацетила, хлорацетила, фенилацетила, бензацетила, p-толуолсульфонила, 2-нитробензолсульфонила, третбутилсульфонила, 2- или 4-нитробензолсульфонила ...

二硝基甲苯的制备方法

甲苯与浓HNO 3 反应制备DNT的方法。这个方法是用甲苯与大量过量的浓HNO 3 在选下条件下反应，可以得到副产物含量大大降低的产品。

팔라듐 촉매제와 그 제조 방법 및 그 이용

본 발명은 하기 NMR 스펙트라의 특성 데이터를 가지는 화합물에 관한 것으로, 상기 화합물은 팔라듐염(II)을 트리[3,5-비스(트리플루오르메틸)-페닐]포스핀과 반응시켜, 착물 염을 형성하고, 착물 염 상태의 팔라듐(II)을 팔라듐(0)으로 환원시켜 촉매 특성을 갖는 팔라듐(0) 착물을 제조하는 단계를 포함하여 제조한 것을 특징으로 하는 화합물이며, NMR 스펙트라의 특성 테이터는 하기와 같다. 1 H-NMR (300 MHz, THF-d8, d= 3.58 ppm) 8.17 (s, 12H), 7.84 (s, 24H); 13 C-NMR(75 MHz, THF-d8, d= 67.3 ppm) 138,1(C), 133.7(q, J=38.7 Hz, C),133.4(CH),126.3(CH),123.4(q, J=271.57 Hz, CF3); 31 P-NMR(300 MHz, THF-d8) 28.77; 19 F-NMR(300 MHz, THF-d8)- 62.94. 이와 같은 화합물은 대단히 안정되고, 우수한 결과를 갖는 촉매제로 이용될 수 있다.

The method of obtaining phenylaminoalkanes

Porous microcomposite of metal cation exchanged perfluorinated ion-exchanged polymer and network of metal oxide, silica or metal oxide and silica

Porous microcomposites comprising a perfluorinated ion-exchange polymer (PFIEP) containing pendant metal cation exchanged sulfonate groups, metal cation exchanged carboxylate groups, or metal cation exchanged sulfonate and carboxylate groups, wherein the metal cation may be ligand coordinated, and optionally pendant sulfonic acid groups, carboxylic acid groups, or sulfonic acid and carboxylic acid groups, the PFIEP being entrapped within and highly dispersed throughout a network of metal oxide, a network of silica or a network of metal oxide and silica can be prepared from PFIEP and one or more precursors selected from the group consisting of a metal oxide precursor, a silica precursor, and a metal oxide and silica precursor using an in situ process. Preferred metal cations are Cr, Sn, Al, Fe, Os, Co, Zn, Hg, Li, Na, Cu, Pd or Ru. Such microcomposites have a first set of pores having a pore size diameter ranging from about 0.5 nm to about 75 nm and may further comprise a second set of pores having a diameter ranging from about 75 nm to about 1000 nm. These microcomposites possess high surface area and exhibit high catalytic activity.

Microencapsulated catalyst methods of preparation and method of use thereof

A microencapsulated catalyst is prepared by dissolving or dispersing a catalyst in a first phase (for example an organic phase), dispersing the first phase in a second, continuous phase (for example an aqueous phase) to form an emulsion, reacting one or more microcapsule wall-forming materials at the interface between the dispersed first phase and the continuous second phase to form a microcapsule polymer shell encapsulating the dispersed first phase core and optionally recovering the microcapsules from the continuous phase. The catalyst is preferably a transition metal catalyst and the encapsulated catalyst may be used for conventional catalysed reactions. The encapsulated catalyst may recovered from the reaction medium and re-cycled.

Method of producing nitrogen mustard derivatives

FIELD: chemistry. SUBSTANCE: invention relates to a method of producing compound (III) or a product which is not protected. Method involves reacting compound (II) with chloroacetic acid in the presence of a reducing agent. PG is a protective group and R is OH in an appropriately protected form or . Invention also relates to methods of producing other intermediate compounds which include the above method, as well as to intermediate compounds. , . EFFECT: invention can be used in synthesis of melphalan and melflufen. 25 cl, 4 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК C07C 227/18 (2006.01) C07C 231/02 (2006.01) C07C 231/12 (2006.01) C07C 237/20 (2006.01) C07C 237/22 (2006.01) C07C 269/06 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА C07C 271/14 (2006.01) ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ C07C 271/20 (2006.01) C07C 271/22 (2006.01) C07K 1/00 (2006.01) (12) (13) 2 715 233 C2 C07K 5/06 (2006.01) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07C 227/18 (2019.08); C07C 231/02 (2019.08); C07C 231/12 (2019.08); C07C 237/20 (2019.08); C07C 237/22 (2019.08); C07C 269/06 (2019.08); C07C 271/14 (2019.08); C07C 271/20 (2019.08); C07C 271/22 (2019.08); C07K 1/006 (2019.08); C07K 5/06078 (2019.08) 2017142725, 06.05.2016 (24) Дата начала отсчета срока действия патента: 06.05.2016 26.02.2020 Приоритет(ы): (30) Конвенционный приоритет: 08.05.2015 GB 1507903.1 (43) Дата публикации заявки: 10.06.2019 Бюл. № 16 (45) Опубликовано: 26.02.2020 Бюл. № 6 (86) Заявка PCT: R U 2 7 1 5 2 3 3 EP 2016/060242 (06.05.2016) (87) Публикация заявки PCT: WO 2016/180740 (17.11.2016) Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, стр. 3, ООО "Юридическая фирма Городисский и Партнеры" (54) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ АЗОТИСТОГО ИПРИТА (57) Реферат: Изобретение относится к способу получения соответствующим образом защищенной форме соединения (III) или его лишенного защиты или продукта, который может найти применение при синтезе мелфалана и мелфлуфена. Способ включает взаимодействие соединения (II) с хлоруксусной ...

Patent SU398031A3

Method of synthesis of mononitrotoluenes

FIELD: chemistry of plastics, chemical technology. SUBSTANCE: method of synthesis of mononitrotoluenes involves interaction of toluene with nitrating agent consisting of sulfuric acid, nitric acid and water and the following adiabatic reaction, separation of the obtained reaction mixture for an organic and inorganic phases and processing the obtained inorganic phase by distillation. Mixing is carried out for 3 s at energy feeding 1-40 Wt/l of the total reaction mixture. Method can be used for production of plastics, dyes and accessory materials. EFFECT: improved method of synthesis, increased selectivity of synthesis of mononitrotoluenes. 9 cl, 1 tbl, 7 ex обес пы Го (19) РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ ВОИ “” 2149 909 ' 57 С 07С 205/06, 201/08 13) СЛ 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 95101857/04, 13.02.1995 (30) Приоритет: 14.02.1994 ОЕ Р 4404614.6 25.03.1994 [ОЕ Р 4410417.0 (46) Дата публикации: 10.10.1998 (71) Заявитель: Байер АГ (ОЕ) (72) Изобретатель: Бернд-Михаэль Кениг (ОЕ), Хельмут Юдат (ОЕ), Хейнц Ульрих Бланк (0Е) (73) Патентообладатель: (56) Ссылки: 1. Ц5, патент, 4973770, кл. С 07 С Байер АГ (ОЕ) <“ 205/06, 1990. 2. ЕР, 0373966, кл, С 07 С С) 201/08, 1990. 3. Ц, патент, 4021498, кл. С 07 С 79/10, 1977, 4. Ц5, патент, 4091042, кл;. С 07 С 79/70, 1978. © (54) СПОСОБ ПОЛУЧЕНИЯ МОНОНИТРОТОЛУОЛОВ © (57) Реферат: адиабатической реакции, разделения © Использование: в химии пластмасс, получаемой реакционной смеси на © красителей и вспомогательных веществ для органическую и неорганическую фазы и получения промежуточных — продуктов. переработки получаемой неорганической = Объектом изобретения является способ фазы путем перегонки, при этом смешивание получения мононитротолуолов — путем проводят в течение до 3 с при подаче энергии <= смешивания толуола с нитрующим средством, 1 - 40 Вт/л общей реакционной смеси. 8 , состоящим из серной кислоты, азотной з.п.ф-лы, 1 табл. с КИСЛОТЫ и ВОДЫ, последующей — О обес ...

偶氮介体

本申请涉及偶氮化合物和它们作为诊断方法中的介体的用途。本申请还涉及包含这类偶氮化合物的检测试剂、试剂盒和测试元件。

Method of producing nanocapsules of trinitrotoluene

FIELD: nanotechnologies. SUBSTANCE: invention relates to nanotechnology, specifically to a method of producing nanocapsules of trinitrotoluene. Method is characterized by that nanocapsules are represented by kappa-carrageenan and trinitrotoluene as a nucleus, wherein trinitrotoluene is slowly added to a suspension of kappa-carrageenan in hexane in presence of 0.01 g of preparation E472c as a surfactant while stirring at 650 rpm. Weight ratio of core: shell in terms of dry substance is 1:3, or 1:1, or 1:2, or 2:1. Then, coolant-113 is added, obtained suspension is filtered and dried at room temperature. EFFECT: disclosed method enables to obtain nanocapsules of trinitrotoluene in a kappa-carrageenan shell. 1 cl, 4 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 699 014 C1 (51) МПК B82B 1/00 (2006.01) B82B 3/00 (2006.01) C06B 45/20 (2006.01) C07C 205/06 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ На основании пункта 1 статьи 1366 части четвертой Гражданского кодекса Российской Федерации патентообладатель обязуется заключить договор об отчуждении патента на условиях, соответствующих установившейся практике, с любым гражданином Российской Федерации или российским юридическим лицом, кто первым изъявил такое желание и уведомил об этом патентообладателя и федеральный орган исполнительной власти по интеллектуальной собственности. (52) СПК (21)(22) Заявка: 2018137752, 25.10.2018 (24) Дата начала отсчета срока действия патента: (73) Патентообладатель(и): Кролевец Александр Александрович (RU) Дата регистрации: 03.09.2019 (56) Список документов, цитированных в отчете о поиске: B.V.N. NAGAVARMA ET AL. Different techniques for preparation of polymeric nanoparticles, ASIAN J. PHARM. CLIN. RES., 2012, Vol. 5, Suppl. 3, 16-23. RU 2646482 C2, 05.03.2018. Приоритет(ы): (22) Дата подачи заявки: 25.10.2018 (54) Способ получения нанокапсул тринитротолуола (57) Реферат: Изобретение относится к области нанотехнологии, конкретно к способу ...

Dnt废水的酸性甲苯萃取

本发明涉及一种处理来自将芳族化合物硝化成单-、二-和三硝基芳族化合物且pH为7.5-13的碱性工艺废水或碱性工艺废水与硫酸浓缩的含水蒸馏物的pH为6-10的混合物W的方法，该方法包括如下步骤：a)通过加入源自硝化所得含硫酸水相后处理的浓缩硫酸而将碱性工艺废水或混合物W酸化为pH值低于2，其中混合物A由分离的有机相和酸性水相组成，和b)用芳族萃取剂萃取混合物A。

Method for the continuous manufacture of a product over at least two mutually coupled chemical reactions

Condensed polycyclic compound and organic light-emitting device, containing thereof

FIELD: chemistry. SUBSTANCE: invention relates to organic light-emitting devices based on condensed polycyclic compound. Light-emitting device includes a pair of electrodes, containing anode and cathode, and layer of organic compound, placed between electrodes and representing emission layer. Layer of organic compound contains, at least, condensed polycyclic compound, characterised by claimed formula, in which radicals, each independently, are selected from the group, consisting of hydrogen atom, phenyl group and phenyl group, substituted with two tert-butyl groups. EFFECT: organic light-emitting device with application of claimed compound has optic output with high efficiency and high brightness, and is durable. 13 cl, 7 dwg, 1 tbl РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК H01L 27/32 (13) 2 519 514 C2 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2012102343/28, 24.01.2012 (24) Дата начала отсчета срока действия патента: 24.01.2012 Приоритет(ы): (30) Конвенционный приоритет: (43) Дата публикации заявки: 27.07.2013 Бюл. № 21 (45) Опубликовано: 10.06.2014 Бюл. № 16 (73) Патентообладатель(и): КЭНОН КАБУСИКИ КАЙСЯ (JP) (54) КОНДЕНСИРОВАННОЕ ПОЛИЦИКЛИЧЕСКОЕ СОЕДИНЕНИЕ И ОРГАНИЧЕСКОЕ СВЕТОИЗЛУЧАЮЩЕЕ УСТРОЙСТВО, СОДЕРЖАЩЕЕ ЭТО СОЕДИНЕНИЕ (57) Реферат: Изобретение относится к органическим соединение, охарактеризованное заявленной светоизлучающим устройствам на основе формулой, в которой радикалы, каждый конденсированного полициклического независимо, выбирают из группы, состоящей из соединения. Светоизлучающее устройство атома водорода, фенильной группы и фенильной включает пару электродов, содержащих анод и группы, замещенной двумя трет-бутильными катод, и слой органического соединения, группами. Органическое светоизлучающее размещенный между электродами и устройство с использованием этого соединения представляющий собой эмиссионный слой. Слой имеет оптический выход с высокой органического соединения ...

Усовершенствованная композиция добавки для контроля и ингибирования полимеризации ароматических виниловых мономеров и способ ее использования

1. Композиция добавки для контроля и ингибирования полимеризации ароматических виниловых мономеров, включающих стирол, состоящая из:(A) одного или более из ароматических нитросоединений, характеризующаяся тем, что указанная композиция дополнительно состоит из:(B) одного или более из алифатических третичных аминов, или их смеси,причем алифатический третичный амин содержит одну или более гидроксильных групп в алкильной цепи третичного амина.2. Композиция добавки по п. 1, отличающаяся тем, что алифатический третичный амин содержит три или четыре гидроксильные группы в алкильной цепи третичного амина.3. Композиция добавки по п. 1, отличающаяся тем, что гидроксильные группы алифатического третичного амина представляют собой гидроксиалкильные группы.4. Композиция добавки по п. 1, отличающаяся тем, что указанный алифатический третичный амин содержит три гидроксильные группы и представляет собой три-изопропанол амин или трис(2-гидроксипропил)амин (TIPA).5. Композиция добавки по п. 1, отличающаяся тем, что указанный алифатический третичный амин содержит гидроксильные группы и представляет собой Ν,Ν,Ν′,Ν′-тетракис(2-гидроксиэтил)этилендиамин) (THEED).6. Композиция добавки по п. 1, отличающаяся тем, что указанный алифатический третичный амин содержит гидроксильные группы и представляет собой Ν,Ν,Ν′,Ν′-тетракис(2-гидроксипропил) этилендиамин).7. Композиция добавки по п. 1, отличающаяся тем, что указанная композиция содержит:(A) одно или более из ароматических нитросоединений, характеризующаяся тем, что указанная композиция дополнительно содержит:(B) один или более из алифатических третичных аминов,отличающаяся тем, что указанный третичный амин выбирают из группы, состоя РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2014 127 330 A (51) МПК C07C 7/20 (2006.01) C07B 63/04 (2006.01) C08F 2/42 (2006.01) C09K 15/18 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2014127330, 03.12.2012 (71) Заявитель(и): ДОРФ КЕТАЛ КЕМИКАЛС (ИНДИЯ) ...

Method for production of dinitrotoluene

FIELD: organic chemistry. SUBSTANCE: dinitrotoluene is prepared by interaction of toluene with high excess of concentrated nitric acid, the process is carried out at definite conditions. EFFECT: decreased amount of side products in compound. 8 cl, 2 tbl ДУ ООС ПЧ Го (19) 13) ВИ “” 2100 347 “Сл 57 С 07С 205/06, 201/08 РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 95108602/04, 13.03.1995 (71) Заявитель: Олин Корпорейшн (5$) (30) Приоритет: 14.09.1992 1$ 944639 (72) Изобретатель: Аллан Б.Квокенбуш[Ц$] (46) Дата публикации: 27.12.1997 (73) Патентообладатель: (56) Ссылки: 1. 4$, патент, 4918250, кл. С 07 С Олин Корпорейшн (ЦЗ) 16/00, 1990. 2. ЦЗ, патент, 5001272, кл. С 07 С 205/06, 1991. 3. 4$, патент, 5099078, кл. С О7С 205/06, 1992. 4. ЦЗ, патент, 5099080, кл. С 07 С 205/06, 1992. (86) Заявка РСТ: 1$ 9308135 (30.08.93) (54) СПОСОБ ПОЛУЧЕНИЯ ДИНИТРОТОЛУОЛА (57) Реферат: концентрированной азотной кислоты при Способ получения — динитротолуола определенных условиях для получения реакцией толуола с концентрированной продукта который имеет значительно азотной кислотой. Способ включает реакцию уменьшенное содержание побочных толуола С большим избытком продуктов. 7 з.п. ф-лы, 2 табл. 2100347 С1 КО ДУ ООС ПЧ Го (19) 13) ВО "2100 347 ^° С1 (51 6 07 С 205/06, 201/08 КУЗЗАМ АСЕМСУ ГОК РАТЕМТ$ АМО ТКАОЕМАКК$ 12) АВЗТКАСТ ОЕ 1МУЕМТОМ (21), (22) АррИсаНоп: 95108602/04, 13.03.1995 (71) АррИсапЕ: От Когроге|5Пп (Ц$) (30) Рнощу: 14.09.1992 1$ 944639 (72) пуетог. — АПап В.Куокеприз | [4$] (46) Рае ог рибИсаНоп: 27.12.1997 (73) Ргорпеюг: (86) РСТ аррИсаНоп: От Когроге]йп (43) 4$ 9308135 (30.08.93) (54) МЕТНОО РОК РКОБУСТЮМ ОЕ ОМПКВОТОГУЕМЕ (57) АБзасе: пис аса, 1ШЛе ргосезз 15 сатед ош а НЕГО: огдапс спептгу. ЗОВЗТАМСЕ: денпие сопайоп$. ЕРЕЕСТ: — Чесгеазеа атИгоо|иепе 15 ргерагеа Бу щегасНоп о аточп{ о{ зае ргодис{$ т сотроипа. 8 <, 245 {оцепе м! Поп ехсезз оГ сопсемгаея 2100347 С1 КО ДУ О0Об0тсС ПЧ ГЭ ...

Конденсированное полициклическое соединение и органическое светоизлучающее устройство, содержащее это соединение

1. Светоизлучающее устройство, включающее:органическое светоизлучающее устройство, включающее:пару электродов, содержащих анод и катод; ислой органического соединения, размещенный между парой электродов,в котором:слой органического соединения представляет собой эмиссионный слой;слой органического соединения содержит, по меньшей мере, конденсированное полициклическое соединение, представленное следующей общей формулой (I):,где радикалы R-R, каждый независимо, выбирают из группы, состоящей из атома водорода, фенильной группы и фенильной группы, замещенной двумя трет-бутильными группами;между эмиссионным слоем и анодом находится слой, обеспечивающий транспорт дырок, имежду эмиссионным слоем и катодом находится слой, обеспечивающий транспорт электронов, иподложку,в которой светоизлучающее устройство имеет структуру с верхней эмиссией, в которой свет, излучаемый из органического светоизлучающего устройства, излучается со стороны, противоположной подложке.2. Светоизлучающее устройство по п.1, в котором R, R, R-R, R-Rи R-Rв общей формуле (I) представляют атом водорода.3. Дисплейное устройство, включающее множество органических светоизлучающих устройств, помещенных на подложку, в качестве пикселя, где каждое из множества органических светоизлучающих устройств включает:пару электродов, содержащих анод и катод; ислой органического соединения, размещенный между парой электродов, в котором:слой органического соединения представляет собой эмиссионный слой;слой органического соединения содержит, по меньшей мере, конденсированное полициклическое соединение, представленное следующей общей формулой (I):,где радикалы R-R, РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК H01L 27/32 (13) 2012 102 343 A (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2012102343/28, 24.01.2012 (71) Заявитель(и): КЭНОН КАБУСИКИ КАЙСЯ (JP) Приоритет(ы): (30) Конвенционный приоритет: (43) Дата публикации заявки: 27.07.2013 Бюл. № 21 (72) Автор(ы): ХОРИУТИ ...

Способ получения динитротолуола

Способ получения динитротолуола реакцией толуола с концентрированной азотной кислотой включает реакцию толуола с большим избытком концентрированной азотной кислоты при определенных условиях для получения продукта, который имеет значительно уменьшенное содержание побочных продуктов.

디니트로톨루엔의제조방법

본 발명은 황산 존재 하에 톨루엔 및 질산으로부터 디니트로톨루엔을 제조하는 2단계 방법에 관한 것이다. 제1 단계에서, 톨루엔 및 질산을 등온 조건 하에서 모노니트로톨루엔이 생성되는 양으로 반응시킨다. 이어서, 반응 혼합물을 유기상 및 산상으로 분리시킨다. 이어서, 유기상을 단열 조건 하에서 질산과 추가로 반응시켜 디니트로톨루엔을 제조한다. 이어서 반응 혼합물을 산상 및 유기상으로 분리시킨다. 유기상으로부터 디니트로톨루엔을 회수한다. 산상으로부터 물 5 중량% 이상을 제거하고 니트로화 반응 동안에 소모된 것을 대신하기 위하여 충분한 질산을 첨가한 후, 산상을 재순환시킨다.

钯催化剂、其制备方法及其用途

本发明涉及式(I)的钯(0)-四{三-[3,5-二(三氟甲基)-苯基]-膦}配合物,以及其制备和用途。该化合物非常稳定，可用作催化剂，具有优异的结果。

Heterocyclic amide derivatives useful as microbiocides

본 발명은 살진균 활성 화학식 I의 화합물, 이들 화합물의 제조방법, 이들 화합물의 제조에 사용되는 신규한 중간체, 하나 이상의 신규한 화합물을 활성 성분으로서 포함하는 농약 조성물, 언급된 조성물의 제조방법 및 농업 또는 원예에서 식물병원성 미생물, 바람직하게는 진균이 식물에 침입하는 것을 방제하거나 예방하기 위한 상기 활성 성분 또는 조성물의 용도에 관한 것이다. The present invention provides fungicidal active compounds of formula (I), methods of preparing these compounds, novel intermediates used in the preparation of these compounds, pesticide compositions comprising at least one novel compound as active ingredient, methods of preparing the mentioned compositions and agriculture Or in the horticulture, the use of said active ingredient or composition for controlling or preventing phytopathogenic microorganisms, preferably fungi, from invading the plant. 화학식 I Formula I 상기 화학식 I에서, In the formula (I) Het는 산소, 질소 및 황으로부터 각각 독립적으로 선택된 1 내지 3개의 헤테로원자를 포함하는 5- 또는 6-원 헤테로사이클릭 환이고, 당해 환은 그룹 R 6 , R 7 및 R 8 에 의해 치환되고, R 1 은 수소, C 1-4 알킬, C 1-4 할로알킬, C 1-4 알콕시, C 1-4 할로알콕시, CH 2 C≡CR 9 , CH 2 CR 10 =CHR 11 , CH=C=CH 2 또는 COR 12 이고; R 2 및 R 3 은 각각 독립적으로 수소, 할로, C 1-4 알킬, C 1-4 알콕시, C 1-4 할로알킬 또는 C 1-4 할로알콕시이고; R 4 및 R 5 는 각각 독립적으로 할로, 시아노 및 니트로로부터 선택되거나; R 4 및 R 5 중 하나는 수소이고, 나머지 하나는 할로, 시아노 및 니트로로부터 선택되고; Het is a 5- or 6-membered heterocyclic ring comprising 1 to 3 heteroatoms each independently selected from oxygen, nitrogen and sulfur, which ring is substituted by groups R 6 , R 7 and R 8 , and R 1 is hydrogen, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 alkoxy, C 1-4 haloalkoxy, CH 2 C≡CR 9 , CH 2 CR 10 = CHR 11 , CH = C = CH 2 or COR 12 ; R 2 and R 3 are each independently hydrogen, halo, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl or C 1-4 haloalkoxy; R 4 and R 5 are each independently selected from halo, cyano and nitro; One of R 4 and R 5 is hydrogen and the other is selected from halo, cyano and nitro; R 6 , R 7 및 R 8 은 각각 독립적으로 수소, 할로, 시아노, 니트로, C 1-4 알킬, C 1-4 할로알킬, C 1-4 알콕시(C 1-4 )알킬, C 1-4 할로알콕시(C 1-4 )알킬 또는 C 1-4 할로알콕시이고, 단, R 6 , R 7 및 R 8 중 적어도 하나는 수소가 아니고; R 9 , R 10 및 R 11 은 각각 독립적으로 수소, 할로, C 1-4 알킬, C 1-4 할로알킬 또는 C ...

基于钡、锶、钾和钠的沸石吸附剂、其制备方法以及其用途

本发明涉及基于包含钡、钾、钠和锶的沸石X的附聚晶体的沸石吸附剂。这些吸附剂用于分离C8芳族异构体的级份并且特别是二甲苯。

基于钡、锶、钾和钠的沸石吸附剂、其制备方法以及其用途

本发明涉及基于包含钡、钾、钠和锶的沸石X的附聚晶体的沸石吸附剂。这些吸附剂用于分离C8芳族异构体的级份并且特别是二甲苯。

Zeolite adsorbents based on barium, strontium, potassium and sodium, preparation process therefor, and uses thereof

The present invention relates to zeolite adsorbents based on agglomerated crystals of zeolite X comprising barium, potassium, sodium and strontium. These adsorbents have applications in the separation of fractions of aromatic C8 isomers and in particular xylenes.

沸石吸附剂、其制备方法和其用途

本发明涉及基于包括钡、钾和钠的附聚的沸石X晶体的沸石吸附剂。这些吸附剂可应用在芳族C8异构体级分且尤其是二甲苯的分离中。

Process for producing nitrobenzene

본 발명은 전체 제조 플랜트가 제조 정지 동안에 셧다운되는 것이 아니라, 제조 플랜트가 전부 또는 적어도 부분적으로 재순환 모드로 작동되는 것인, 단열 조건하에 질산과 황산으로 벤젠을 니트로화하는 것에 의해 니트로벤젠을 연속 제조하는 방법에 관한 것이다. 추가로 본 발명은 니트로벤젠의 제조를 위한 플랜트 및 니트로벤젠의 제조를 위한 플랜트의 작동 방법에 관한 것이다. The present invention relates to the continuous production of nitrobenzene by nitrating benzene with nitric acid and sulfuric acid under adiabatic conditions, wherein the production plant is operated wholly or at least partially in recycle mode, rather than the entire production plant being shut down during production shutdown. It's about how to do it. The invention further relates to a plant for the production of nitrobenzene and to a method of operating the plant for the production of nitrobenzene.

new palladium catalyst, method for its preparation and use

A process for preparing dinitrotoluene

본 발명은 진한 질산과 톨루엔을 반응시켜 디니트로톨루엔을 제조하기 위한 방법에 관한 것이다. 본 방법에서, 실질적으로 부산물 함량이 감소된 생성물을 생성하는 선택된 조건에서 과량의 진한 질산과 톨루엔을 반응시킨다. The present invention relates to a process for preparing dinitrotoluene by reacting concentrated nitric acid with toluene. In this process, excess concentrated nitric acid and toluene are reacted at selected conditions to produce a product with substantially reduced byproduct content.

Process for the production of nitrobenzenes.

PROCESS FOR BIARIL PRODUCTION