07-11-2019 дата публикации
Номер: US20190337916A1
Принадлежит:
Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL). 2. The method according to claim 1 , wherein X and Y are carbon atoms bound by a double bond having claim 1 , independently claim 1 , an E or Z configuration.3. The method according to claim 1 , wherein{'sub': 1′', 'A', 'A', 'A', '2', 'A', '3', 'A', '2', 'A', '3', 'A', 'A', '3, 'R is hydrogen, halogen, OR, OC(═O)R, SR, SOR, SOR, OSOR, OSOR, C(R);'}{'sub': 2′', '3′', '1', '2', '3', 'B', 'B', 'B', 'B', 'B', '2', 'B', '3', 'B', '2', 'B', '3', 'B', 'B', '2', 'B', 'B', '2', 'B', '3, 'R, R, R, R, Rare the same or different and independently selected from: hydrogen; halogen; OR; C(═O)R; C(═O)OR; OC(═O)R; SR; SOR; SOR; OSOR; OSOR; N(R); NHC(═O)R; C(═O)N(R); C(R);'}{'sub': A', 'B', '1-7', '5-7', '5-7, 'at each occurrence, Rand Rare independently selected from: hydrogen; a linear or branched, saturated or unsaturated Caliphatic group optionally containing up to three heteroatoms independently selected from nitrogen, oxygen and sulfur; a Ccycloalkyl group; a phenyl group; a Cheterocyclic group;'}4. The method according to claim 1 , wherein{'sub': 1′', 'A', 'A', 'A', '2', 'A', '3', 'A', '2', 'A', '3', 'A', 'A', '3, 'R is hydrogen, halogen, OR, OC(═O)R, SR, SOR, SOR, OSOR, OSOR, C(R);'}{'sub': 2′', '3′', '1', '2', '3', '1-7', '5-7', '5-7, 'R, R, R, R, Rare the same or different and independently selected from: a linear or branched, saturated or unsaturated Cacyclic aliphatic group optionally containing up to three heteroatoms independently selected from nitrogen, oxygen or sulfur; a Ccycloalkyl group; a phenyl group; a Cheterocyclic group; and'}{'sub': 'A', 'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'Rhas the meaning indicated in .'}5. The method according to claim 1 , whereinX and Y are carbon atoms bound by a double bond having, independently, an E or Z configuration;{'sub': 1′', 'A, 'R is OR;'}{'sub': '2′', 'R is hydrogen;'}{' ...
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