Способ получения 2,2-дизамещенных циклоалкан-1,3-дионов

Prodn. of carbonyl cpd. by oxidn. of alcohol with chloro-aromatic cpd.

Prodn. of carbonyl cpds. (I) comprises reacting the corresp. prim. or sec. alcohols (II) with a chlorinated aromatic cpd. (III) in presence of a complex transition metal catalyst (IV).

Lösungsmittel zum Herstellen eines organischen Transistors

Es wird ein Lösungsmittel für die Herstellung eines organischen Transistors bereitgestellt. Das Lösungsmittel weist eine ausgezeichnete Löslichkeit für organische Halbleitermaterialien auf und ermöglicht die Bildung eines organischen Transistors mit hoher Kristallinität. Das erfindungsgemäße Lösungsmittel für die Herstellung eines organischen Transistors schließt ein Lösungsmittel A ein, das durch Formel (a) wiedergegeben ist. In der Formel bedeutet Ring Z einen Ring, der ausgewählt ist aus einem aromatischen Kohlenstoffring, einem 5- bis 7-gliedrigen alicyclischen Kohlenstoffring und einem 5- bis 7-gliedrigen heterocyclischen Ring; R1 bedeutet eine Gruppe, die ausgewählt ist aus Oxo, Thioxy, -ORa, -SRa, -O(C=O)Ra, -RbO(C=O)Ra, und substituiertem oder unsubstituiertem Amino; und R2 bedeutet eine Gruppe, die ausgewählt ist aus Wasserstoff, C1-C7-Alkyl, Aryl und -ORa, wobei R1 und R2 miteinander verbunden sein können unter Bildung eines Rings mit einem oder mehreren Kohlenstoffatomen, die ...

Glyoxyl-Cyclohexendione.

Chemical processes

PROCESS FOR THE MANUFACTURE OF 2,2,-DISUBSTITUTED CYCLOALKANE- 1,3-DIONES

... 1351852 2,2-Disubstituted cycloalkane-1,3- diones; intermediates therefor SCHERING AG 19 April 1971 [4 April 1970] 25625/71 Heading C2C The invention comprises a process for the manufacture of 2,2-disubstituted cycloalkane- 1,3-diones of the general formula in which n is 1 or 2, R 1 is a C 1 -C 4 aliphatic hydrocarbon group and R 2 is hydrogen or an organic group by reacting a 2-substituted cycloalkane-1,3-dione of the general formula in a liquid medium and in the absence of a basic catalyst with a vinyl ketone of formula R 2 CH 2 COCH 2 = CH 2 and also certain of the 2,2-disubstituted cycloalkane-1,3-diones per se. Preferred starting vinyl ketones are those in which R 2 represents R 3 -(CH 2 ) m - in which m is 0, 1 or 2 and R 3 is hydrogen, a free or esterified carboxyl group; a free, etherified or esterified alpha-hydroxyalkyl group containing 2-4 carbon atoms; a halogen-alkenyl group containing 2-5 carbon atoms; a ketalized oxoalkyl group containing 2-4 carbon atoms; or a phenyl group ...

Process for the preparation of cycloalkane-1,3-diones

... 1,136,496. cycloalkane - 1,3 - diones. DEUTSCHE AKADEMIE DER WISSENSCHAFTEN ZU BERLIN. 16 Aug., 1966, No. 36601/66. Heading C2C. 2-Alkyl substituted cyclopentane- or cyolohexane-1,3, diones are prepared by (a) reacting RCH 2 COOH wherein R is the alkyl group at position 2 in the product, with an acid halide or anhydride of a 1,2 or 1,3-alkane dioic acid; or (b) reacting an acid halide or anhydride of RCH 2 COOH with said dioic acid; or (c) reacting an acid halide or anhydride of RCH 2 COOH with an acid halide or anhydride of said dioic acid; or (d) reacting a mixture of RCH 2 OH and said dioic acid after said mixture has been treated with SOCl 2 or SOBr 2 , said reactions (a), (b), (c) and (d) being carried out in the presence of a Friedel-Kraft catalyst with or without the use of a solvent, e.g. nitromethane or 1,2-dichloro-ethane.

Supported ruthenium nanoparticle catalyst for CIS- dihydroxylation and oxidative cleavage of alkenes

The present invention relates to the use of nanosized metal particles (e.g., ruthenium) grafted on inert solid support for oxidation of alkenes. The supported metal catalyst can effect cis-dihydroxylation and oxidative cleavage of alkenes to give the respective cis-diols and carbonyl products.

Reactants for charge transfer reactions in mass spectrometers

Herbicidal substituted 2-[1-(oxyamino)-alkylidene-cyclohexane-1,3-diones and derivatives

Herbicidally active compounds, particularly against grassy weeds, are represented by the general formula: wherein R is alkyl or 1 to 6 carbon atoms or phenyl; R<1> is haloalkyl or 1 to 6 carbon atoms, haloalkenyl of 2 to 6 carbon atoms, haloaryl of 6 to 10 carbon atoms, halobenzyl, all of which contain 1 to 3 halogen atoms, cycloalkyl of 5 to 7 carbon atoms, or benzyl substituted by 1 to 3 alkyl groups of 1 to 4 carbon atoms or haloalkyl groups of 1 to 4 carbon atoms and 1 to 9 halogen atoms; R<2> and R<3> are independently hydrogen, alkyl of 1 to 3 carbon atoms, alkylthio of 1 to 6 carbon atoms, or alkylthioalkyl of 2 to 8 carbon atoms; R<4> is hydrogen or carbalkoxy of 2 to 4 carbon atoms; and R<5> is hydrogen, a cation, or wherein R<6> is alkyl of 1 to 6 carbon atoms or aryl of 6 to 10 carbon atoms. Preferably R, R<2> and R<3> are alkyl and R<4> and R<5> are hydrogen. The compounds may be used in both pre- and post-emergent applications.

PROCESS FOR METHYLATING CYCLOALIPHATIC KETONES

... 1448855 Alkylation catalyst HOECHST AG 23 Nov 1973 [24 Nov 1972 24 May 1973] 54428/73 Heading B1E [Also in Division C2] In Example 1, -Al 2 O 3 (pore volume 0.45- 0.5 g H 2 O/ml, surface 66 m2/g) is impregnated with aqueous CuNO 3 and then aqueous KOH, washed, dried, reduced with H 2 and the reduced catalyst is impregnated with aqueous Didymium acetate and dried. In Example 2, copper oxide on magnesium silicate is reduced with hydrogen and impregnated with potassium hydroxide. In Example 3, y-alumina is impregnated with acetic acid solutions of copper acetate and diymium oxide, dried and reduced.

PROCESS FOR THE MANUFACTURE OF CYCLOHEXANE-1,3-DIONES AND 6 - ALKYL - 3,4 - DIHYDRO - 2 PYRANONES

OPTICALLY ACTIVE CYCLOHEXENE DERIVATIVES

... 1508197 Cyclohexene derivatives F HOFFMANN-LA ROCHE & CO AG 20 Aug 1975 [21 Aug 1974] 47891/76 Divided out of 1508195 Heading C2C The invention comprises [3R]-3-hydroxyretinyl acetate, [3R]-3-hydroxy-retinol, [3R]-3- hydroxy retinal and and [3R]-3-acetoxy-retinyl acetate. [3R] - 3 - Hydroxy - retinyl acetate may be prepared by reacting a 4-{[4R]-4- hydroxy - 2,2,6 - trimethyl - cyclohex - 1 - en- 1 - yl} - but - 3 - ene - 2 - triarylphosphonium halide with 1-acetoxy-3-methyl-hexa-2,4-dien- 6-al. Saponification of this product yields [3R]- 3-hydroxy-retinol which may be oxidized to [3R]-3-hydroxy-retinal. Alternatively [3R]-3- hydroxy-retinyl acetate may be prepared by reacting [3R] - 3 - hydroxy - # - ionylidenethyltriphenylphosphonium chloride with -acetoxytiglic aldehyde. [3R] - 3 - acetoxy - retinyl acetate may be prepared by reacting [3R]-3- hydroxy-retinyl acetate with acetic anhydride in pyridine.

ZUSAMMENSETZUNGEN AUF BASIS VON VINYLCHLORIDPOLYMEREN

PROCEDURE FOR THE PRODUCTION OF CYCLOHEXANON

COMPOSITIONS ON BASIS OF VINYL CHLORIDE POLYMERS

PROCEDURE FOR the PRODUCTION of the OPTICALLY ACTIVE ONE (4R, 6R) - 4-HYDROXY-2,2,6-TRIMETHYL-CYCLOHEXANON

PROCEDURE FOR the PRODUCTION of the OPTICALLY ACTIVE ONE (4R, 6R) - 4-HYDROXY-2,2,6-TRIMETHYL-CYCLOHEXANON

GLYOXYL CYCLOHEXENDIONE ONE.

CYCLI DIONE SUBSTITUTED HERBICIDES.

Procedure for the production of Trichinoyl

D-AMINO ACID AMIDES

Substituted cyclohexane derivatives, processes for their preparation and the use of the compounds for treating diseases

PROCESS FOR THE PREPARATION OF NEW BENZYLAMINO-ACANOIC ACIDS ANDS COMPOUNDS THEREOF

DE DIVULGATION L'invention a pour objet l'obtention des composés de formule générale I: (I) dans laquelle R1 représente un radical alcoyle inférieur ayant de 3 à 6 atomes de carbone en chaîne linéaire ou ramifiée, R2 et R4, simultanément ou distinctement, représentent de l'hydrogène, ou un radical alcoyle inférieur linéaire ou ramifié, R3 représente de l'hydrogène, un atome d'halogène, un radical alcoxy inférieur ou un radical trifluorométhyle, A et B, identiques ou différents, représentent de l'hydrogène, un radical méthyle ou un radical éthyle, n est un nombre entier variant de 4 à 10, et Z représente hydrogène, un radical OR" dans lequel R" est un radical alcoyle inférieur, un radical alcoyle inférieur dont la chaîne alcoyle est substituée, un radical phényle ou un radical phényle substitué, ou -un radical dans lequel R et R', simultanément ou distinctement, représentent de l'hydrogène, un radical alcoyle inférieur, un radical alcényle inférieur, un radical phényle, un radical phényle alcoyle inférieur ou bien R' et R forment ensemble une chaîne alcoylène ayant de 2 à 6 atomes de carbone, éventuellement interrompue par un ou deux hétéroatomes, et des sels des composés de formule I avec un acide minéral ou organique, ainsi que des sels des composés de formule I avec une base minérale ou organique. Les composés de formule générale I manifestent des propriétés pharmacologiques intéressantes notamment dans le domaine neuro-psychiatrique.

PROCESS FOR THE MANUFACTURE OF CYCLOHEXANE-1,3-DIONES AND 6-ALKYL-3,4-DIHYDRO-2-PYRANONES

HERBICIDAL SUBSTITUTED 2-(1-OXYAMINO)-ALKYLIDENE)- CYCLOHEXANE-1,3-DIONES

Verfahren zur Herstellung von Ringketonen

Procédé pour la préparation de céto-esters alicycliques

Verfahren zur Herstellung von 2-Azetyl-1,3-diketonen

Verfahren zur Herstellung von Cycloalkan-1.3-dionen

Verfahren zur Herstellung von in a-Stellung substituierten organischen Carbonylverbindungen

VERFAHREN ZUR HERSTELLUNG VON HYDROBENZOPYRAN-DERIVATEN.

Composition aromatisante

Cyclic perfume additive like juniper essence - synthesised from elemol by dehydration followed by epoxidiation

Perfume additive contains a cyclic cpd. of formula: able to contain 1 or 2 exocyclic double bonds in the bridge positions, where (a) m, n are 1 and one X is OH or o-acyl and the other is H, or both X's are O and Y is H; (b) m, n are 1, one Y is OH or o-acyl and the other is H or both Y's are O and X is H; (c) m, n are O and 1 resp. or 2 and 0 resp.

Verfahren zur Herstellung von Carbonylverbindungen

Utilisation de dicétones comme odorants dans la préparation de compositions parfumées

Pharmaceutical compositions containing triquinoyl or

Compositions containing cpd. (I) and its polymers (II) Redox agents. For the treatment of blockage of electron-transfer, and the treatment of cancer. Compositions containing cpds. (I) and (II) and: (a) pharmaceutical diluents; (b) cpds. of molecular weight less than cpd. (I), especially glyoxal or methylglyoxal; (c) NiSO4, CoSO4, MnSO4, MbSO4, FeSO4, CuSO4, or ZnSO4. Solutions as in (a), (b) or (c) in unit doses of 2 ml.

Stabilised composition based on polyvinyl chloride

The composition contains, relative to the polymer, 0.1 to 5 % by weight of at least one organic salt of a metal and 0.05 to 5 % by weight of at least one cyclic beta -ketonic organic compound. Such compositions resist yellowing and thermal degradation at elevated temperatures which may be up to 230 DEG C.

Process for the preparation of new benzylaminoalkanoic acids

... omega -Benzylaminoalkylcarboxylic acids of formula: in which R1 represents a C3-C6 alkyl, R2 and R4 represent hydrogen or a lower alkyl, R3 represents hydrogen, a halogen, a lower alkoxy or the CF3 group, A and B represent hydrogen or a methyl or ethyl group and n represents an integer from 4 to 10, are prepared by condensation of an acid R1CO-(CAB)n-COOH with a benzylamine R3C6H4-CHR4-NHR2 under reducing conditions. These compounds, their salts and their optical isomers are novel and are distinguished by antiagressive properties; they can be used for the treatment of depressive states or of anxiety.

USE OF CYCLOHEXANE DERIVATIVES IN LIQUIDCRYSTALLINE DIELECTRICS.

AT LEAST ONE CYCLOHEXANE DERIVATIVE AS A OF AT LEAST TWO COMPONENTS ABSTENTION, LIQUID DIELECTRIC.

Di:methyl-cyclohexene-alkenone cpds.

Perfuming and aromatising compsns. are claimed contg. as active ingredient a cpd. of formula (I) in which the ring may be satd., or have a double bond in posns. 1,4 or 6. or two double bonds in posns. 1 and 4, 1 and 5 or 4 and 6, n is 0, 1 or 2; Z may be bound to posns. 1 or 6 and is a gp. CO, COR8 or C(OR9)2, in which R8 is 1-6C acyl gp. and R9 is 1-6C alkyl or 2-6C alkylene gp.; Y is O or CH2; R1-5 are H or one of R1-5 is CH3 and the remainder are H; and R6 and R7 are 1-3C alkyl.In an exceptional case, cpd. (I) has a double bond in posn. 1 or 6, Z is O and is bound to posn. 1, Y is CH2, n is 1, R1-5 are H and R6 and R7 are CH3.(I) impart a green, fruity, woody, note to perfume and aromatising compsns. and are used e.g. at 0.01-5%, esp. 0.01-2% in compsns. used to impart or to build the fragrance of food, drinks, tobacco, cosmetics, detergents, soap, etc.

SUBSTITUTED 2 (1 (OXYAMINO) - ALKYLIDEN) - CYCLOHEXAN-1,3-DIONE, THESE CONTAINING HERBICIDES COMPOSITIONS AND PROCEDURES FOR KILLING OF PLANTS.

Substituted cyclohexanes

A PROCESS FOR REVAMPING A PLANT FOR THE PRODUCTION OF CYCLOHEXANONE

Heterocyclic compounds

PROCESS FOR THE PREPARATION OF CYCLOHEXANE-DIONES -1,3-AND ALKYL 6-DIHYDRO -3,4-PYRANONES -2

COMPOSES IMINES DE SYNTHESE CONTENANT UN ATOME DE CARBONE QUATERNAIRE CHIRAL, LEUR PREPARATION ET LEUR UTILISATION

LA PRESENTE INVENTION CONCERNE DES COMPOSES DE SYNTHESE POSSEDANT UN ATOME DE CARBONE QUATERNAIRE CHIRAL, UNE METHODE GENERALE DE SYNTHESE PAR INDUCTION ASYMETRIQUE DE CES COMPOSES AINSI QUE LEUR APPLICATION A L'OBTENTION DE PRODUITS ORGANIQUES, EN PARTICULIER DE PRODUITS NATURELS. CES COMPOSES IMINES DE SYNTHESE CONTIENNENT EN A UN ATOME DE CARBONE CHIRAL QUATERNAIRE, SUBSTITUE EN G PAR UN GROUPE FONCTIONNALISE ET AYANT LA FORMULE: (CF DESSIN DANS BOPI) ()SIGNIFIE QUE L'ATOME DE CARBONE CORRESPONDANT EST CHIRAL, DE CONFIGURATION ABSOLUE R OU S.

NOVEL BENZOPYRAN DERIVATIVES

PREPARATION OF ALICYCLIC DIKETONES

METHOD FOR OXIDATION OF CYCLOALKANES

NOVEL BENZOPYRAN DERIVATIVES, INTERMEDIATES THEREOF, AND PREPARING [...]

Method for producing triquinoyl and/or hydrate thereof by electrolytic oxidation

Provided is a method for producing triquinoyl and/or a hydrate thereof with high yield under mild conditions while generating less waste. Tetrahydroxy-p-benzoquinone, a metal salt thereof and/or a hydrate thereof is subjected to electrolytic oxidation to produce triquinoyl and/or a hydrate thereof. It is preferred that the electrolytic oxidation is carried out using a separated-type electrolysis vessel or the electrolytic oxidation is carried out under neutral or acidic conditions.

A method for producing cyclohexanone dimer

The present invention provides a method for producing cyclohexanone dimer comprising performing the cyclohexanone condensation reaction in a presence of solid acid catalyst to obtain the cyclohexanone dimer; wherein the solid acid catalyst comprises tungsten oxide and a carrier with Lewis acid sites and Brønsted acid sites. The method of present invention has an advantage of mild condition, fast reaction rate and high selectivity, thereby enhancing the value of the industrial application.

SETT ATT FRAMSTELLA NYA BENSYLAMINOALKANSYROR

Compounds and methods for altering lifespan of eukaryotic organisms

Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5-butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation.

СПОСОБ ПОЛУЧЕНИЯ ЦИКЛОГЕКСАНОНА

FIELD: chemistry. SUBSTANCE: invention relates to a method of producing cyclohexanone from cyclohexane, involving the following stages: oxidation of cyclohexane to hydroperoxide of cycohexyl with oxygen in the absence of a catalyst, purification of the reaction medium by washing with water, decomposition of hydroperoxide of cycohexyl to cyclohexanol and cyclohexanone in the presence of a catalyst, extraction of the cyclohexanol/cyclohexanone mixture for separating unreacted cyclohexane and separation of products with boiling point higher than that of the cyclohexanol/cyclohexanone mixture, dehydrogenating cyclohexanol contained in the cyclohexanol/cyclohexanone mixture, in the presence of a dehydrogenation catalyst, distillation of the obtained mixture so as to obtain first run (F 1 ) at the first stage, containing compounds with boiling point lower than that of cyclohexanone, and a last run (Q 1 ) and distillation of the last run (Q 1 ) to obtain a first run (F 2 ) at the second stage, formed from cyclohexanone, and a last run (Q 2 ). EFFECT: obtaining highly pure cyclohexanone, suitable for use as raw material for synthesis of ε-caprolactam. 6 cl, 1 dwg, 3 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 373 181 (13) C2 (51) МПК C07C 49/403 (2006.01) C07C 45/53 (2006.01) C07C 45/39 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (30) Конвенционный приоритет: 07.12.2004 FR 0412976 (73) Патентообладатель(и): РОДИА ШИМИ (FR) (43) Дата публикации заявки: 20.01.2009 C 2 2 3 7 3 1 8 1 R U C 2 (56) Список документов, цитированных в отчете о поиске: EP 0450498 A1, 09.10.1991. GB 1018557 A, 26.01.1966. US 4918239 A, 17.04.1990. SU 1836321 A3, 23.08.1993. RU 2078753 C1, 10.05.1997. Zhao Y.-Y. et al. The determination of impurities in caprolactam by capillary gas chromatography-mass spectrometry. Microchemical Journal, 2001, т.69, №3, с.213-127 (реферат). FR 1428064 A, 27.04.1966. EP 0579323 B1, 25.09.1996. ...

СПОСОБ ПОЛУЧЕНИЯ ЦИКЛОГЕКСАНОНА

... 1. Способ получения циклогексанона, отличающийся тем, что он включает следующие стадии: окисление циклогексана в гидропероксид циклогексила кислородом в отсутствие катализатора, очистка реакционной среды путем промывки водой, разложение гидропероксида циклогексила на циклогексанол и циклогексанон в присутствии катализатора, извлечение смеси циклогексанол/циклогексанон для отделения непрореагировавшего циклогексана и отделение продуктов с более высокой температурой кипения, чем у смеси циклогексанол/циклогексанон, дегидрогенизация циклогексанола, содержащегося в смеси циклогексанол/циклогексанон, в присутствии катализатора дегидрогенизации, перегонка полученной смеси, чтобы получить на первой стадии перегонки головной погон (F1), содержащий соединения с температурой кипения ниже температуры кипения циклогексанона, и хвостовой погон (Q1), перегонка хвостового погона (Q1), чтобы получить на второй стадии перегонки головной погон (F2), образованный циклогексаноном, и хвостовой погон(Q2). 2.

КАТАЛИЗАТОРЫ ОКИСЛЕНИЯ ЦИКЛОАЛКАНОВ И СПОСОБ ПОЛУЧЕНИЯ СПИРТОВ И КЕТОНОВ

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2017 126 074 A (51) МПК C07C 29/48 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2017126074, 18.12.2015 (71) Заявитель(и): РОДИА ОПЕРАСЬОН (FR) Приоритет(ы): (30) Конвенционный приоритет: 22.12.2014 EP 14290400.2 03 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 24.07.2017 EP 2015/080410 (18.12.2015) (87) Публикация заявки PCT: R U Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, стр. 3, ООО "Юридическая фирма Городисский и Партнеры" (54) КАТАЛИЗАТОРЫ ОКИСЛЕНИЯ ЦИКЛОАЛКАНОВ И СПОСОБ ПОЛУЧЕНИЯ СПИРТОВ И КЕТОНОВ (57) Формула изобретения 1. Способ окисления циклоалкана с образованием смеси продуктов, содержащей соответствующие спирт и кетон, при этом указанный способ включает приведение в контакт циклоалкана с гидропероксидным соединением в присутствии по меньшей мере катализатора на основе оксида церия. 2. Способ по п. 1, где циклоалкан выбран из группы, состоящей из циклопентана, циклогексана, циклогептана и циклооктана. 3. Способ по п. 2, где циклоалкан представляет собой циклогексан, спирт представляет собой циклогексанол, и кетон представляет собой циклогексанон. 4. Способ по любому из пп. 1-3, где гидропероксидное соединение представляет собой соединение, соответствующее формуле (I), представленной ниже: R-O-O-H (I) где R представляет собой углеводородную группу, содержащую от 1 до 15 атомов углерода. 5. Способ по п. 4, где гидропероксидные соединения выбраны из группы, состоящей из трет-бутилгидропероксида, трет-амилгидропероксида, гидропероксида кумола, гидропероксида этилбензола, циклогексилгидропероксида, метилциклогексилгидропероксида, гидропероксида тетралина, гидропероксида Стр.: 1 A 2 0 1 7 1 2 6 0 7 4 A WO 2016/102343 (30.06.2016) 2 0 1 7 1 2 6 0 7 4 (86) Заявка PCT: R U (43) Дата публикации заявки: 24.01.2019 Бюл. № (72) Автор(ы): ШУЗЬЕ, Сандра (FR), ОКАМПО, Фабьен (FR), МАСТРОЯННИ, Серджо (FR), КОРМА, Авелино (ES), БОРОНАТ, ...

Verfahren zur Herstellung von ª‡-Lobelin

HETEROCYCLISCHE VERBINDUNGEN

Verfahren zur Herstellung von Ketonen

Acetyl diketones and their production

Polyketones containing the grouping are obtained by reacting isopropenyl acetate with an anhydride or a halide of a carboxylic acid in the presence of a Lewis acid catalyst. Reaction of isopropenyl acetate with an anhydride or halide of a monocarboxylic acid yields acyclic products, but cyclic products are obtained from an anhydride or halide of a dicarboxylic acid, provided that the latter can be cyclisized. The preferred catalyst is aluminium chloride, but the use of titanium tetrachloride is also mentioned. Examples are given in which isopropenyl acetate yields (1) 2-acetylcyclopentane-1,3-dione by reaction with succinic anhydride or succinyl chloride, (2) 2-acetylcyclohexane-1,3-dione by reaction with glutaric anhydride, (3) 2-acetyl-4-methylcyclopent-4-ene-1,3-dion by reaction with citraconic anhydride, (4) 2-acetyl-indane-1,3-dione by reaction with phthalic anhydride, (5) triacetylmethane by reaction with acetic anhydride, (6) 2-acetylcycloheptane-1,3-dione by ...

4-CYANO-3-OXO-HEXAHYDRO-ISOQUINOLINE DERIVATIVES

BENZYLAMINOALKANOIC ACIDS PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

... 1472627 Benzylamino - alkanoic acids SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 10 Sept 1975 [10 Sept 1974] 39443/74 Heading C2C The invention comprises compounds of the formula wherein R 1 is a (C 3 -C 6 ) straight or branched chain alkyl radical, each of R 2 and R 4 is H or a (C 1 -C 5 ) straight or branched chain alkyl radical, R 3 is H, halogen, diethylaminoethoxy alkoxy or CF 3 , A and B are each selected from H, CH 3 or C 2 H 5 , and n is an integer from 4 to 10; including optically active isomers thereof and salts with acids or bases. They may be obtained by condensing an oxoalkanoic acid of the formula with a benzylamine of the formula reducing the product obtained, and if salts are required, adding thereto a mineral or organic base or acid. Pharmaceutical compositions having anti. aggressive activity comprise compounds of formula I above in admixture with a pharmaceutically suitable carrier. They may be applied parenterally, orally or rectally. Compounds of formula ...

PREPARATION OF ALICYCLIC DIKETONES

... 1418590 Tea and tobacco compositions; flavourings FIRMENICH SA 16 Nov 1973 [16 Nov 1972] 53230/73 Headings A2B and A2C [Also in Division C2] 2, 2, 5-Trimethyl-cyclohex-5-en-1, 4-dione and 2, 2, 5, 6-tetramethyl-cyclohex-5-en-1, 4- dione are used to modify the organoleptic properties of tobacco and black tea.

Novel cyclic diketones and ketals thereof and a process for the manufacture of the same

The invention comprises cyclic diketones of formula wherein the broken line indicates that a double bond may be present in the 2,3-position, and 4 : 4-ketals thereof, such as 2 : 6 : 6-trimethyl4 : 4 - ethylenedioxy - cyclohexen - (2) - one and 2 : 6 : 6 - trimethyl - 4 : 4 - ethylenedioxy - cyclohexanone. The diketones and ketals are prepared by oxidizing 2 : 6 : 6 - trimethyl - cyclohexen - (2) - ol - (1) - one - (4) (cf. Specification 791,954) to give 2 : 6 : 6-trimethyl-cyclohexen-(2)-dione-(1 : 4) and, if desired, hydrogenating the nuclear double bond and/or ketalizing the 4-oxo group. The oxidation may be carried out in known manner using, e.g. chromic acid or tertiary butyl chromate or manganese dioxide or aluminium isopropoxide or phenoxide in the presence of carbonyl compounds. The hydrogenation may be carried out using zinc and acetic acid. The ketals may be prepared by known methods. In examples: 2 : 6 : 6-trimethyl - cyclohexen - (2) - ol - (1) - one ...

SUBSTITUTED CYCLOHEXANE DERIVATIVES, PROCEDURES FOR YOUR PRODUCTION AND THE USE OF THE CONNECTIONS TO THE TREATMENT OF DISEASES

FLUESSIGKRISTALLINES DIELEKTRIKUM

COMPOSITIONS ON BASIS OF VINYL CHLORIDE POLYMERS

LIQUIDCRYSTALLINE DIELECTRIC

METHODS FOR MAKING RETINOIDS AND USES THEREOF

... ²²²Described herein are methods for making retinoids. Also described herein are ²retinoids and methods of use thereof.² ...

4-CYANO-2,3,5,6,7,8-HEXAHYDRO-3-OXO-ISOQUINOLINE COMPOUNDS

An isoquinoline derivative of the following formula: (I) wherein R1 is a methyl or a methoxymethyl group and R2 and R3 are each a hydrogen atom or a lower alkyl, a lower alkoxyl, a cyclohexyl, a phenyl, a substituted phenyl, a pyridyl or an oxo (= O) group; and therapeutically acceptable salts thereof which exhibit a low toxicity and a wide range of safety and are highly useful as a cardiac.

LIQUID CRYSTAL COMPOUNDS

Novel compounds, 4-alkyl-cyclohexenes having at the 1-position thereof p-cyanophenyl group or 4'-cyano-4-biphenylyl group. expressed by the general formula wherein R represents a straight alkyl group having 1-9 carbon atoms and n represents 1 or 2; methods for producing the same; and nematic liquid crystal (L.C.) compositions comprising at least one member selected from the group consisting of said compounds, are provided. Said compounds having a cyclohexene ring have a lower viscosity than conventional L.C. compounds, and have effectivenesses of short response time when applied to L.C. display apparatus; superior compatibility with other L.C. compounds to form convenient L.C. mixture; and no need of separating cis- and trans-forms in the midway step of the preparation as in the prior art.

CERTAIN GLYOXYL-CYCLOHEXENDIONES

T 931 FF CERTAIN GLYOXYL-CYCLOHEXENDIONES Compounds of formula I (I) are useful as herbicides, effective against dicotyledonous weeds. PS18001 ...

METHOD OF RECONSTRUCTION OF INSTALLATION FOR PRODUCTION OF CYCLOHEXANONE

Racemic gamma-irone, useful as perfume or aromatising agent - prepd. from trans-2,6-methyl-6-gamma-cyclocitral and a phosphorane

Process for the preparation of cyclic ketones

DERIVED FROM CYCLOHEXANE USEFUL LIKE LIQUID CRYSTALS

FLAVOURING

CYCLOHEXANONE

Heterocyclic compounds

1,3-DICARBONYL COMPOUNDS AND PROCESS FOR THEIR PREPARATIO

New isoquinoline derivatives and their therapeutic applications

PALLADIUM-CATALYZED ASYMMETRIC (HETERO)ARYLATION AND VINYLATION OF KETONE ENOLATES TO PRODUCE TERTIARY STEREOCENTERS AT ALPHA(α)-POSITION

The invention relates to new ligands that are used in a palladium source catalyst system and in palladium catalyzed method for asymmetric α-(hetero)arylation and a-vinylation of ketones. The invention further relates to a process for preparing an asymmetric α-(hetero)arylated or a-vinylated ketone which comprises reacting the tin enolate of the ketone in the presence of catalyst system comprising a ligand of the invention and palladium source. By means of the ligands and process of the invention a stereogenic center in position a of the ketone is established with high enantiomeric excess.

Process for the preparation of a solution containing semitrichinoyl

A process for the preparation of a stable solution of semitrichinoyl is disclosed. A solution of rhodizonic acid and a solution of trichinoyl octahydrate is mixed and subjected to the action of light. The solutions of rhodizonic acid and trichinoyl occtahydrate have the same molarity, whereby a solution of semitrichinoyl is formed. Pursuant to a preferred embodiment: (a) an aqueous solution containing about 1% by weight of inositol is chlorinated in the presence of light at a temperature of between about 40 DEG C. and 60 DEG C., (b) the reaction solution (RL) thus obtained is filtered, (c) the filtrate is neutralized with a solution of sodium hydrogen carbonate and, by adding a small amount of barium chloride, precipitating the low-molecular polymerized barium salt compounds (R2), (d) adding again barium chloride to the filtered-off solution, and (e) then adding to the precipitate (R3) thus obtained a sulfuric acid produced by the reaction of (1) one part of a mixture of acetaldehyde and ...

PROCESS FOR PRODUCING CYCLOHEXANOL AND CYCLOHEXANONE

The invention concerns a method for preparing a mixture containing cyclohexanol and cyclohexanone, comprising the step of hydrogenating cyclohexyl hydroperoxide in cyclohexane in the presence of a Raney nickel catalyst to give cyclohexanol and cyclohexanone.

Branched amides of L-aspartyl-D-amino acid dipeptides and compositions thereof

СПОСОБ СИНТЕЗА ЦИКЛОГЕКСЕНОНОВ И ИХ ПРИМЕНЕНИЕ В ПАРФЮМЕРИИ

FIELD: chemistry.SUBSTANCE: invention relates to a process for preparing cyclohexenones and cyclohexenols having pleasant odors and special aftereffect properties, to new cyclohexenones and cyclohexenols, to a flavoring composition and to the use of cyclohexenones and cyclohexenols as flavoring agents.EFFECT: invention can be used in the manufacture of cosmetics, perfumes and detergents.13 cl, 1 tbl, 46 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК C07C 29/20 (2006.01) C07C 29/143 (2006.01) C07C 41/01 (2006.01) C07C 45/62 (2006.01) C07C 45/68 (2006.01) C07C 67/08 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА C07C 35/18 (2006.01) ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ C07C 35/21 (2006.01) C07C 43/188 (2006.01) C07C 49/603 (2006.01) (12) (13) 2 663 619 C2 C07C 49/613 (2006.01) C07C 49/647 (2006.01) C07C 49/657 (2006.01) C07C 69/14 (2006.01) C07C 69/145 (2006.01) C07C 69/157 (2006.01) A61Q 13/00 (2006.01) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК (21)(22) Заявка: 2015116505, 24.09.2013 (24) Дата начала отсчета срока действия патента: (73) Патентообладатель(и): В. МАН ФИС (FR) Дата регистрации: 07.08.2018 (56) Список документов, цитированных в отчете о поиске: Ю.Гура и др. Исследование в Приоритет(ы): (30) Конвенционный приоритет: 05.10.2012 FR 1259524 (45) Опубликовано: 07.08.2018 Бюл. № 22 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 05.05.2015 R U 2 6 6 3 6 1 9 (86) Заявка PCT: FR 2013/052235 (24.09.2013) (87) Публикация заявки PCT: WO 2014/053744 (10.04.2014) Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, стр. 3, ООО "Юридическая фирма Городисский и Партнеры" (54) СПОСОБ СИНТЕЗА ЦИКЛОГЕКСЕНОНОВ И ИХ ПРИМЕНЕНИЕ В ПАРФЮМЕРИИ (57) Реферат: Изобретение относится к способу получения и моющих средств, к новым циклогексенонам и циклогексенонов и циклогексенолов, обладающих циклогексенолам, к ароматизирующей приятными запахами и свойствами особого композиции и к применению циклогексенонов и последействия, которые могут быть использованы циклогексенолов в качестве ...

ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ ЦИКЛОГЕКСАНА

Производные циклогексана формулы I, где R1 - CN или COOH, R2 - C1-10-алкил(R11)n, O-C1-C10-алкил(R11)n, O-C3-C10-алкенил(R11)n, O-C3-C10 алкинил(R11)n, S-C1-C10-алкил(R11)n, причем R11 может быть замещен R12; R12, R3, R11, R13 - C1 -C10-алкил, C3-C8-циклоалкил, фенил, нафтил, пиридил, тиенил, имидазолил, фурил, индолил, хинолин или их тиено- или бнзоанеллированные производные, причем ароматический или гетероароматический остаток может быть замещен фтором, хлором, OH, CF3, CN, C1-C4-алкоксилом, фенилом или O-фенилом, R4, R5 - H, OH, обычная для гидроксила защитная группа или принимают значения, указанные для R2; R6 - H, Y - (CH2)m, Z - (CH2)m, S, - CH = C - (C1-C4-алканоил), - CH = C (R13), - CH2- CO-, C3-C10-циклоалкилен, причем 1 - 3 атома кольца могут быть замещены атомами азота, -C≡C- или -CH = C (C1-C4-алкилом), n = 0, 1, 2, m = 0, 1, 2, 3, 4, а также их физиологически приемлемые соли. Соединения I ингибируют глюкозо-6-фосфатазную систему печени млекопитающих, что должно приводить к ...

ЦИКЛОАЛКИЛИДЕНОВЫЕ СОЕДИНЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ, ИХ ПРИМЕНЕНИЕ И СПОСОБ СЕЛЕКТИВНОГО СВЯЗЫВАНИЯ ERalpha- И ERbeta-ЭСТРОГЕНОВЫХ РЕЦЕПТОРОВ

FIELD: chemistry. SUBSTANCE: present invention pertains to new cycloalkylidene compounds with formula (I), to their pharmaceutical salts, esters and amide, capable of selective bonding ERα- and ERβ-estrogen receptors, as well as to pharmaceutical compositions based on them, their use in making medicinal preparations and the method of selective bonding ERα- and ERβ-estrogen receptors. . Denotations of R 1 -R 7 , X, p, q, as well as specific representatives of new cycloalkylidene compounds are given in the formula of invention. EFFECT: obtaining new cylcoalkylidene compounds. 31 cl, 6 dwg, 108 ex

Compounds and Methods for Altering Lifespan of Eukaryotic Organisms

Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5-butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation. 11.) The compound of claim 1 , wherein the compound is selected from the following: 1 claim 1 ,3-cyclohexanedione claim 1 , 2-acetyl-5-[4-(N claim 1 ,N-dimethylamino)phenyl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2-cyclopentanecarbonyl-5-[4-methylphenyl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2-cyclopentanecarbonyl-5-[4-(1-methylethyl)phenyl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2-cyclopentanecarbonyl-5-[4-chlorophenyl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2-cyclopentanecarbonyl-5-[fur-2-yl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2-isobutyryl-5-[fur-2-yl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2-benzoyl-5-[2-chloro-6-fluorophenyl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2-propanoyl-5-[4-methoxyphenyl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2-acetyl-5-[3 claim 1 ,4-dimethoxyphenyl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2-benzoyl-5-[3 claim 1 ,4-dimethoxyphenyl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2-acetyl-5-[naphth-2-yl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2-benzoyl-5-[2 claim 1 ,4-dichlorophenyl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2-propanoyl-5-[2 claim 1 ,4 claim 1 ,5-trimethoxyphenyl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2-benzoyl-5-[4-fluorophenyl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2-benzoyl-5-[4-methoxyphenyl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2-benzoyl-5-[fur-2-yl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2-cyclopropanecarbonyl-5-[4-methoxyphenyl]-; 1 claim 1 ,3-cyclohexanedione claim 1 , 2- ...

"CYCLOHEXANONE COMPOSITIONS"

Described herein are compositions having (a) at least 99 wt % cyclohexanone; and (b) 0.1 wppm to 1000 wppm of at least one of cyclohexanedione and hydroxycyclohexanone. The wt % and wppm are based upon the total weight of the composition. The compositions may further comprise 0.1 wppm to 1000 wppm of cyclohexanol. 1. A composition comprising:(a) at least 99 wt % cyclohexanone; and(b) 0.1 wppm to 1000 wppm of at least one of cyclohexanedione and hydroxycyclohexanone, wherein the wt % and wppm are based upon the total weight of the composition.2. The composition of claim 1 , wherein the composition comprises 0.1 wppm to 100 wppm of at least one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.3. The composition of claim 1 , wherein the composition comprises 0.1 wppm to 10 wppm of at least one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.4. The composition of claim 1 , wherein the composition comprises 0.1 wppm to 1 wppm of at least one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.5. The composition of claim 1 , wherein the composition comprises 0.1 wppm to 100 wppm of each one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.6. The composition of claim 1 , wherein the composition comprises 1 wppm to 100 wppm of at least one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.7. The composition of claim 1 , wherein the composition comprises 2 wppm to 100 wppm of at least one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.8. The composition of claim 1 , wherein the composition comprises 0.1 wppm to 1000 wppm of cyclohexanol claim 1 , based upon the total weight of the composition.9. The composition of claim 1 , wherein the composition comprises 0.1 ...

Phenol and Cyclohexanone Mixtures

Disclosed herein is a process for producing phenol. The process includes oxidizing at least a portion of a feed comprising cyclohexylbenzene to produce an oxidation composition comprising cyclohexyl-1-phenyl-1-hydroperoxide. The oxidation composition may then be cleaved in the presence of an acid catalyst to produce a cleavage reaction mixture comprising the acid catalyst, phenol and cyclohexanone. At least a portion of the cleavage reaction mixture may be neutralized with a basic material to form a treated cleavage reaction mixture. In various embodiments, the cleavage reaction mixture contains 1 wt % to 30 wt % phenol, 1 wt % to 30 wt % cyclohexanone and a complexation product. 1. A mixture comprising:(a) 1 wt % to 30 wt % phenol;(b) 1 wt % to 30 wt % cyclohexanone; and(c) a complexation product,wherein the wt % s are based upon total weight of the mixture.2. The mixture of claim 1 , wherein the complexation product is a salt of sodium sulfate.3. The mixture of claim 1 , wherein the mixture further comprises water.4. The mixture of claim 1 , wherein the complexation product is a complex of (CHNH).HSO.5. The mixture of claim 1 , wherein the complexation product is a complex of (HN(CH)NH).HSO.6. The mixture of claim 1 , wherein the complexation product has a normal boiling above phenol.7. The mixture of claim 1 , wherein the complexation product is soluble in the mixture.8. The mixture of claim 1 , wherein the complexation product does not decompose at temperatures above 200° C.9. The mixture of claim 1 , wherein the complexation product is substantially inert to other components in the mixture.10. The mixture of claim 1 , wherein the mixture comprises 5 wt % to 15 wt % cyclohexanone claim 1 , based upon the total weight of the treated mixture.11. The mixture of claim 1 , wherein the mixture comprises 5 wt % to 15 wt % phenol claim 1 , based upon the total weight of the mixture.12. The mixture of claim 1 , wherein the mixture comprises 5 wt % to 15 wt % of phenol ...

Process For Production of Ketones From Secondary Alcohols

The present invention relates to the process for production of ketones from secondary alcohols by the use of a hybrid material, formed by the dichlorohydrotris(pyrazol-1-yl)methane iron (II) complex covalently bound to multi-walled carbon nanotubes functionalized with superficial carboxylate groups, as efficient and selective catalyst of peroxidative oxidation, microwave-assisted and without solvent addition. 1. A process for production of ketones from secondary alcohols , assisted by microwave radiation comprising the mixture of an oxidising agent with a hybrid , material dichlorohydrotris (pyrazol-1-yl) methane iron (II) covalently bound to multi-walled carbon nanotubes functionalized with superficial carboxylate groups as catalyst , at a temperature of 80° C.2. The process according to claim 1 , wherein the oxidising agent is a 70% aqueous solution of tert-butyl hydroperoxide.3. The process according to claim 1 , wherein the dichlorohydrotris (pyrazol-1-yl) methane iron (II) complex contains an iron content of 2% (w/w).4. The process according to claim 1 , wherein the secondary alcohols are selected from: cyclohexanol claim 1 , 1-phenylethanol claim 1 , o- claim 1 , m- or p-cresols claim 1 , linear alcohols such as 2-hexanol claim 1 , 3-hexanol claim 1 , 1-butanol or 2-butanol claim 1 , and diols claim 1 , among others.5. The process according to claim 1 , wherein the reaction time is one hour.6. The process according to claim 1 , which is free from solvent addition.7. The process according to claim 1 , wherein the catalyst dichlorohydrotris (pyrazol-1-yl) methane iron (II) covalently bound to multiple wall carbon nanotubes functionalized with superficial carboxylate groups is reusable in at least six subsequent catalytic cycles. The present invention relates to the process for production of ketones from secondary alcohols by the use of a hybrid material, formed by the dichlorohydrotris(pyrazol-1-yl)methane iron (II) complex covalently bound to multi-walled ...

Method For Forming Cyclohexanone From Cyclohexanol

A method for forming cyclohexanone from cyclohexanol is provided in which two or more cyclohexanol dehydrogenation reactors and associated condensers are operably connected in series so as to increase relative concentration of cyclohexanone in the formed product through the use of Le Châtelier's principle. 1. A method for forming cyclohexanone from cyclohexanol , the method comprising:introducing liquid cyclohexanol into a first cyclohexanol dehydrogenation reactor;vaporizing the liquid cyclohexanol within the first cyclohexanol dehydrogenation reactor to form vaporized cyclohexanol;dehydrogenating the vaporized cyclohexanol in the presence of a dehydrogenation catalyst to form vaporized cyclohexanone and hydrogen gas;condensing the formed vaporized cyclohexanone and any remaining vaporized cyclohexanol within a first condenser to form liquid cyclohexanone and liquid cyclohexanol;removing the formed hydrogen gas;vaporizing the formed liquid cyclohexanone and liquid cyclohexanol within a second cyclohexanol dehydrogenation reactor to form vaporized cyclohexanone and vaporized cyclohexanol;dehydrogenating the vaporized cyclohexanol from the second cyclohexanol dehydrogenation reactor in the presence of a dehydrogenation catalyst to form additional vaporized cyclohexanone and additional hydrogen gas; andcondensing the formed vaporized cyclohexanone and formed additional vaporized cyclohexanone and any remaining vaporized cyclohexanol within a second condenser to form liquid cyclohexanone and liquid cyclohexanol as a product.2. The method according to claim 1 , further comprising:separating the liquid cyclohexanone from the liquid cyclohexanol of the product within a first distillation unit.3. The method according to claim 2 , further comprising:removing the formed additional hydrogen gas.4. The method according to claim 1 , wherein the step of vaporizing the liquid cyclohexanol within the first cyclohexanol dehydrogenation reactor comprises heating the liquid ...

Process for Making Cyclohexanone and/or Phenol

In a process for separating a mixture comprising cyclohexanone and phenol, a solid-phase basic material, such as basic ion-exchange resin, is used to remove acid and/or sulfur from the mixture prior to separation. The process results in reduced amount of contamination such as cyclic ethers in the cyclohexanone and/or phenol products. 1. A process for separating a first mixture comprising cyclohexanone , phenol , cyclohexylbenzene , and a sulfur-containing component , comprising the following steps:(I) contacting the first mixture with a pre-distillation solid-phase basic material to produce a second mixture comprising the sulfur-containing component at a concentration lower than in the first mixture;(II) supplying the second mixture into a distillation column operating at a temperature of at least 120° C.; and(III) obtaining an upper effluent and a lower effluent from the first distillation column, wherein the upper effluent has a higher concentration in cyclohexanone than the lower effluent, and the lower effluent has a higher cyclohexylbenzene concentration than the upper effluent.2. The process of claim 1 , wherein at least one of the following conditions is met:(i) the first mixture comprises sulfur at a total concentration in a range from 80 ppm to 2000 ppm by weight, based on the total weight of the first mixture; and(ii) the first mixture comprises sulfuric acid at a concentration in a range from 80 ppm to 2000 ppm by weight, based on the total weight of the first mixture.3. The process of claim 1 , wherein at least one of the following conditions is met:(i) the second mixture comprises sulfur at a total concentration no greater than 10 ppm by weight, based on the total weight of the second mixture; and(ii) the second mixture comprises sulfuric acid at a concentration no greater than 10 ppm by weight, based on the total weight of the second mixture.4. The process of claim 1 , wherein at least one of the following conditions is met:(i) the upper effluent ...

NANOPARTICLE CATALYSTS FOR CONVERSION OF CYCLOHEXANOL TO CYCLOHEXANONE

Methods for converting an alcohol, such as cyclohexanol to a ketone, such as cyclohexanone, include reacting the alcohol in the presence of a catalyst and oxygen to produce the ketone. In one exemplary embodiment, the catalyst comprises a microporous copper chloropyrophosphate framework including a plurality of noble metal nanoparticles. In one exemplary embodiment, the noble metal nanoparticles include at least one metal selected from the group consisting of platinum, palladium, and gold. 1. A catalyst comprising a microporous copper chloropyrophosphate framework comprising a plurality of noble metal nanoparticles , the catalyst activated in a reducing atmosphere.2. The catalyst of claim 1 , wherein the microporous copper chloropyrophosphate framework has the general formula:{'br': None, 'sub': 9', '6', '2', '7', '4', '4', 'y, '[ACu(PO)Cl].[MX]Cl'}{'sub': '4', 'claim-text': M is selected from Cu, Au, Pt, and Pd;', 'X is selected from Cl and Br; and', 'y is 2 when M is Pt, Pd, or Cu and y is 3 when M is Au., 'where: A is selected from K, Rb, Cs, and NH;'}3. The catalyst of claim 2 , wherein the microporous copper chloropyrophosphate framework has a general formula selected from the group consisting of:{'sub': 9', '6', '2', '7', '4', '4', '4', '9', '6', '2', '7', '4', '3', '4', '9', '6', '2', '7', '4', '3', '4, 'RbCu(PO)Cl(AuCl), RbCu(PO)Cl(PtCl), and RbCu(PO)Cl(PdCl).'}4. The catalyst of claim 1 , wherein the catalyst comprises precursor complexes that result in isolated noble metal nanoparticle sites upon activation.5. The catalyst of claim 4 , wherein the precursor complexes are selected from the group consisting of [PtCl] claim 4 , [PdCl] claim 4 , and [AuCl].6. The catalyst of claim 1 , wherein the noble metal nanoparticles include at least one metal selected from the group consisting of platinum claim 1 , palladium claim 1 , and gold.7. The catalyst of claim 6 , wherein the microporous copper chloropyrophosphate framework includes a plurality of mono-metallic ...

Process for Producing Phenol and Cyclohexanone

In a process for separating a mixture comprising cyclohexanone and phenol, at least a portion of the mixture is distilled in the presence of a solvent including at least two alcoholic hydroxyl groups attached to non-adjacent saturated carbon atoms, water, and in the presence or absence of a hemiketal defined by the formula (I) or the formula (II): wherein R 1 , the same or different at each occurrence, is independently an alkylene group having from 2 to 10 carbon atoms, R 2 is an alkylene group having from 4 to 10 carbon atoms and/or R 3 is hydrogen or the following group: and in the presence or absence of an enol-ether derived from the hemiketal defined by the formula (I) or the formula (II), wherein the total concentration of the hemiketal and enol-ether, expressed in term of weight percentage of the total weight of the feed to the distilling step, is at most 0.01%.

Cyclohexanone-Containing Products and Processes for Making the Same

Disclosed are a process for abating 3-cyclohexenone from a feed mixture comprising 3-cylclohexenone and cyclohexanone, comprising a hydrogenation step of contacting the feed mixture with hydrogen in the presence of a hydrogenation catalyst under hydrogenation conditions to obtain a hydrogenated mixture, cyclohexanone-containing products comprising 3-cyclohexenone and/or 2-cyclohexenone at low concentrations, and compositions of matter useful for making such cyclohexanone-containing products, particularly by using such processes. 1. A process for abating 3-cyclohexenone from a feed mixture comprising 3-cylclohexenone , cyclohexanone and optionally phenol , comprising a hydrogenation step of contacting the feed mixture with hydrogen in the presence of a hydrogenation catalyst under hydrogenation conditions to obtain a hydrogenated mixture , and obtaining from the hydrogenated mixture a cyclohexanone-containing product substantially free of phenol and comprising , based on the total weight thereof: at least 10 wt % of cyclohexanone; 0 to 90 wt % of cyclohexanol; and no more than 20 ppm by weight of 3-cyclohexenone.2. The process of claim 1 , wherein the feed mixture comprises 3-cyclohexenone at a concentration in the range from 30 ppm by weight to 5 wt % claim 1 , based on the total weight of the feed mixture.3. The process of claim 1 , wherein the conversion of 3-cyclohexenone in the hydrogenation step is at least 95%.4. The process of claim 1 , wherein the hydrogenated mixture comprises 3-cyclohexenone at a concentration of no higher than 20 ppm by weight claim 1 , based on the total weight of the hydrogenated mixture.5. The process of claim 1 , wherein the feed mixture comprises 2-cyclohexenone at a concentration in the range from 30 ppm by weight to 5 wt % claim 1 , based on the total weight of the feed mixture.6. The process of claim 5 , wherein the conversion of 2-cyclohexenone is at least 95% in the hydrogenation step.7. The process of claim 5 , wherein the ...

Process and System for Making Cyclohexanone

Disclosed are processes and systems for making cyclohexanone from a mixture comprising phenol, cyclohexanone, and cyclohexylbenzene comprising a step of or a device for subjecting at least a portion of the mixture to hydrogenation and a step of or a device for distilling a phenol/cyclohexanone/cyclohexylbenzene mixture to obtain an effluent rich in cyclohexanone.

Chemical liquid purification method and chemical liquid

An object of the present invention is to provide a chemical liquid purification method which makes it possible to obtain a chemical liquid having excellent defect inhibition performance. Another object of the present invention is to provide a chemical liquid. The chemical liquid purification method according to an embodiment of the present invention is a chemical liquid purification method including obtaining a chemical liquid by purifying a substance to be purified containing an organic solvent, in which a content of the stabilizer in the substance to be purified with respect to the total mass of the substance to be purified is equal to or greater than 0.1 mass ppm and less than 100 mass ppm.

Process for Making Cyclohexanone

Disclosed are novel processes for making cyclohexanone compositions, from a mixture comprising phenol, cyclohexanone, and cyclohexylbenzene. The process includes hydrogenation of a feed stream comprising phenol, cyclohexanone, and cyclohexylbenzene. The feed stream may be subjected to one or more pre-hydrogenation treatments, such as passing through one or more sorbents, addition of basic chemical agents, and/or addition of water, so as to improve catalyst activity, minimize undesired side reactions, and/or remove catalyst poisons from the feed stream. The feed stream may be provided to a hydrogenation reaction zone in the vapor phase, with periodic alterations to hydrogenation reaction conditions such that the feed is provided in mixed liquid and vapor phase in order to carry out liquid washing of a hydrogenation catalyst bed within the hydrogenation reaction zone. 1. A process comprising:(a-1) during a first period of time, continuously providing hydrogen and hydrogenation feed comprising phenol, cyclohexanone, and cyclohexylbenzene to a hydrogenation reaction zone in which a hydrogenation catalyst bed is disposed, thereby maintaining a reaction medium flowing through the hydrogenation catalyst bed within the hydrogenation reaction zone;(a-2) during the first period of time, maintaining initial temperature and initial pressure conditions within the hydrogenation reaction zone such that the reaction medium is entirely in vapor phase during the first period of time;(b) adjusting the initial temperature conditions, the initial pressure conditions, or both, within the hydrogenation reaction zone to obtain liquid washing temperature and pressure conditions within the hydrogenation reaction zone, such that the reaction medium is in mixed liquid and vapor phase after the adjusting; and(c) during a second period of time subsequent to the first period of time, maintaining the liquid washing temperature and pressure conditions within the hydrogenation reaction zone while ...

Processes for Making Cyclohexanone

Disclosed are processes for abating 3-cyclohexenone from a feed mixture comprising cyclohexylbenzene, cyclohexanone, phenol, and 3-cylclohexenone and cyclohexanone, comprising feeding the feed mixture to a first distillation column and a hydrogenating a fraction from in the presence of a hydrogenation catalyst under hydrogenation conditions. Hydrogenation can be carried out in a hydrogenation reactor separate from the first distillation column or in a hydrogenation zone disposed inside the first distillation column. 1. A process for producing cyclohexanone from a first feed mixture comprising cyclohexylbenzene , cyclohexanone , phenol , and 3-cyclohexenone , the process comprising:feeding the first feed mixture into a first distillation column at a first feeding location on the first distillation column;obtaining a cyclohexylbenzene-rich lower effluent from the first distillation column;obtaining a first upper effluent from a first upper effluent location on the first distillation column above the first feeding location, the first upper effluent comprising phenol, cyclohexanone, and 3-cyclohexenone;feeding at least a portion of the first upper effluent to a hydrogenation reactor, where the first upper effluent contacts with hydrogen in the presence of a hydrogenation catalyst under hydrogenation conditions to produce a hydrogenation reactor effluent substantially free of 3-cylcohexenone;feeding at least a portion of the hydrogenation reactor effluent to a second distillation column, andobtaining an cyclohexanone-rich upper effluent and a phenol-rich lower effluent from the second distillation column.2. The process of claim 1 , wherein the concentration of 3-cyclohexenone in the first feed mixture is in the range from 30 ppm by weight to 1 wt % claim 1 , based on the total weight of the first feed mixture.3. The process of claim 1 , wherein in the hydrogenation reactor claim 1 , the conversion of 3-cyclohexenone is at least 95%.4. The process of claim 1 , wherein the ...

PROCESS FOR THE PURIFICATION OF A CYCLOHEXANE AIR OXIDATION PRODUCT STREAM

A method is disclosed for removing contaminants from a feed stream to a hydrogenation process that begins with providing a product mixture from an air oxidation reaction. A first liquid separation process and cooling procedure is used on the product mixture to form a cooled product mixture and a first vapor stream. The cooled product mixture is then subjected to a water wash to form a washed product mixture and an aqueous exit stream, wherein a majority of the water soluble other oxidation products from the cooled product mixture are present in the aqueous exit stream. Next, the washed product stream undergoes a second liquid separation and water removal to form a treated product mixture and a second vapor stream. Finally, the treated product mixture is recovered and can be fed to a hydrogenation process. 1. A method for treating a feed stream to a hydrogenation process , comprising the steps of:(a) providing a product mixture from an air oxidation reaction comprising of desired products, dissolved gases, and other oxidation products;(b) cooling the product mixture of step (a) in a first liquid separation process to form a cooled product mixture and a first vapor stream, wherein about 98 wt % to about 99.5 wt % of the dissolved gases from the product mixture of step (a) are present in the first vapor stream and greater than 98 wt % of the desired products from the product mixture of step (a) are present in the cooled product mixture;(c) contacting the cooled product mixture of step (b) with water to form a washed product mixture and an aqueous exit stream, wherein a majority of the water soluble other oxidation products from the cooled product mixture of step (b) are present in the aqueous exit stream;(d) removing water from the washed product mixture of step (c) in a second liquid separation process to form a treated product mixture and a second vapor stream, wherein greater than 98 wt % of the desired products from the washed product mixture of step (c) are ...

Process for Producing Phenol

In a process for producing phenol, cyclohexylbenzene hydroperoxide is cleaved to produce a cleavage effluent stream comprising phenol and cyclohexanone and at least a portion of the cleavage effluent stream is fractionated to produce a first fraction richer in cyclohexanone than the cleavage effluent stream portion and a second fraction richer in phenol and depleted in cyclohexanone as compared with said cleavage effluent stream portion. At least a portion of the second fraction is then contacted with a dehydrogenation catalyst in a dehydrogenation reaction zone under dehydrogenation conditions effective to convert at least a portion of the cyclohexanone in said second fraction portion into phenol and cyclohexanol. 1. A process for producing phenol , the process comprising:(a) cleaving cyclohexylbenzene hydroperoxide to produce a cleavage effluent stream comprising phenol and cyclohexanone;(b) fractionating at least a portion of the cleavage effluent stream to produce (i) a first fraction richer in cyclohexanone than said portion of the cleavage effluent stream; and (ii) a second fraction richer in phenol and depleted in cyclohexanone than said portion of the cleavage effluent stream; and(c) contacting at least a portion of the second fraction with a dehydrogenation catalyst in a dehydrogenation reaction zone under dehydrogenation conditions effective to convert at least a portion of the cyclohexanone in said portion of the second fraction into phenol and cyclohexanol.2. The process of claim 1 , wherein the first fraction comprises no more than 1000 ppm of phenol claim 1 , based upon the total weight of the first fraction.3. The process of claim 1 , wherein the weight ratio of phenol to cyclohexanone in said portion of the cleavage effluent stream in (b) is less than or equal to 2.57.4. The process of claim 1 , wherein the weight ratio of phenol to cyclohexanone in said portion of the cleavage effluent stream in (b) is about 0.7 to about 1.5.5. The process of claim ...

Cyclic Imide Slurry Compositions

Provided herein is a cyclic imide slurry composition and processes for forming and/or using such a composition. The slurry composition comprises solid cyclic imide and organic liquid, such as liquid alkylbenzene, liquid cyclohexane, and/or liquid organic alcohol (such as cyclohexanol). The slurry composition may find particular use in processes in which the cyclic imide serves as an oxidation catalyst (e.g., as a radical initiator). For instance, the slurry composition may be useful in the oxidation of a liquid alkylbenzene such as cyclohexylbenzene to corresponding 1-cyclohexyl-1-phenyl hydroperoxide. Such an oxidation reaction may further be part of an integrated process for the production of phenol and/or cyclohexanone from benzene via hydroalkylation to form cyclohexylbenzene. 1. A process comprising:(a) feeding a solid cyclic imide and a liquid alkylbenzene to a mixing device;(b) within the mixing device, forming a slurry comprising 3 wt % to 45 wt % of the solid cyclic imide in the liquid alkylbenzene;(c) providing the slurry and an oxygen-containing gas to a mixed gas/liquid oxidation reaction zone; and(d) oxidizing at least a portion of the alkylbenzene in the mixed gas/liquid oxidation reaction zone in the presence of the cyclic imide, thereby forming a corresponding alkylbenzene-hydroperoxide.3. The process of claim 2 , wherein the cyclic imide is N-hydroxyphthalimide (NHPI).5. The process of claim 4 , wherein the alkylbenzene is cyclohexylbenzene claim 4 , and the alkylbenzene-hydroperoxide is cyclohexyl-1-phenyl-1-hydroperoxide.6. The process of claim 5 , further comprising:(a-1) contacting benzene with hydrogen under hydroalkylation conditions in the presence of a hydroalkylation catalyst to produce cyclohexylbenzene;(a-2) feeding a first portion of the cyclohexylbenzene to the mixing device; and(a-3) feeding a second portion of the cyclohexylbenzene to the oxidation reaction zone.7. The process of claim 1 , further comprising measuring mass flow rate ...

ENTECAVIR INTERMEDIATE, SYNTHETIC METHOD THEREOF AND SYNTHETIC METHOD FOR ENTECAVIR

The disclosure relates to an entecavir intermediate, a synthetic method therefor, and the synthetic method for entecavir by using the intermediate. According to the disclosure, the synthetic methods for entecavir and the intermediate thereof have the advantages of being controllable in chirality, high in yield and product purity, wide in source of raw materials, cheap and available in reagents, simple in reactions, convenient to operate, environmentally friendly, and suitable for industrial amplification production. 4. The synthetic method for the entecavir intermediate having the structure shown in Formula 10 according to claim 3 , wherein the reaction solvent in step (a) is methanol claim 3 , the base is sodium hydroxide claim 3 , the oxidizing agent is hydrogen peroxide claim 3 , reaction temperature of the epoxide reaction is −5 to 10 DEG C. claim 3 , and molar ratio of the D(+)-carvone claim 3 , the base and the oxidizing agent is 1:(0.1 to 0.3):(0.8 to 1.4); and/orthe reaction solvent in step (b) is tetrahydrofuran, the acid is trifluoroacetic acid, the chloride reagent is anhydrous lithium chloride, the reaction temperature of the chlorination ring-opening reaction is 0 to 35 DEG C., and the molar ratio of the compound of Formula 2, the acid and the chloride reagent is 1:(0.8 to 2):(0.8 to 2).5. The synthetic method for the entecavir intermediate having the structure shown in Formula 10 according to claim 2 , wherein the reaction solvent in step (c) is selected from at least one of methylene chloride claim 2 , 1 claim 2 ,2-dichloroethane claim 2 , chloroform claim 2 , water claim 2 , ethyl acetate claim 2 , diethyl ether claim 2 , methyl tertiary butyl ether and tetrahydrofuran claim 2 , the base is selected from 4-dimethylaminopyridine or a combination of 4-dimethylaminopyridine with other bases claim 2 , the esterification reagent is p-toluenesulfonyl chloride claim 2 , the reaction temperature of the reaction is 0 to 50 DEG C. claim 2 , and the molar ratio ...

PROCESS FOR PREPARATION OF MOLINDONE

The present invention provides process for preparation of molindone (I) comprising: a) reacting compound with cyclohexane-1,3-dione to form 2-(2-oxopentan-3-yl)cyclohexane-1,3-dione wherein X is Cl, Br or I, b) cyclizing 2-(2-oxopentan-3-yl)cyclohexane-1,3-dione to 2-methyl-3-ethyl-4-oxo-4,5,6,7-tetrahydroindole, c) reacting 2-methyl-3-ethyl-4-oxo-4,5,6,7-tetrahydroindole with morpholine and formaldehyde to give molindone (I), and d) optionally converting molindone (I) to its salt. The present invention further provides process for preparation of compound comprising: a) reacting compound with ethyl halide and another halide source to form compound wherein R is alkyl and X is Cl, Br or I; b)converting compound to compound. 4. The process according to claim 1 , wherein the cyclization process of step (b) is carried out in presence of reagent selected from ammonium acetate claim 1 , aqueous ammonia claim 1 , methanolic ammonia claim 1 , ammonium chloride or urea and choline chloride.5. The process according to claim 2 , wherein ethyl halide is selected from ethyl iodide claim 2 , ethyl bromide or ethyl chloride.6. The process according to claim 2 , wherein halide source is selected from N-chlorosuccimide claim 2 , N-bromosuccinimde claim 2 , N-Iodosuccinimide orsulfuryl chloride.7. The process according to claim 2 , wherein compound (2′) is converted to compound (2) by treating with acid selected from hydrochloric acid claim 2 , sulfuric acid claim 2 , acetic acid or para toluene sulfonic acid.8. The process according to claim 1 , wherein molindone salt is hydrochloride salt.9. The process according to claim 1 , wherein the reaction of compound (2) and cyclohexane-1 claim 1 ,3-dione is carried out in presence of solvent and base.10. The process according to claim 9 , wherein the solvent is selected fromacetonitrile claim 9 , propionitrile claim 9 , butyronitrile claim 9 , ethyl acetate claim 9 , ethyl acetoacetate claim 9 , butyl acetate claim 9 , propyl acetate claim ...

Trans-metallated mof catalyst

A metal organic framework comprising zinc (II) ions and second metal ions, such as iron (II) ions, cobalt (II) ions, and copper (II) ions as nodes or clusters and coordinated 1,3,5-benzenetricarboxylic acid struts or linkers between them forming a porous coordination network in the form of polyhedral crystals that are isostructural to HKUST-1. Transmetallation processes for producing the metal organic frameworks, as well as methods for applications of the metal organic frameworks as catalysts, specifically catalysts for the oxidation of cyclic hydrocarbons, such as toluene, cyclohexane, and methylcyclohexane.

SOLVENT FOR PRODUCING ORGANIC TRANSISTOR

Provided is a solvent for organic transistor production. The solvent has excellent solubility for organic semiconductor materials and enables formation of an organic transistor having high crystallinity. The solvent according to the present invention for organic transistor production includes a solvent A represented by Formula (a). In the formula, Ring Z represents a ring selected from an aromatic carbon ring, a 5- to 7-membered alicyclic carbon ring, and a 5- to 7-membered heterocyclic ring; Rrepresents a group selected from oxo, thioxy, —OR, —SR, —O(C═O)R, —RO(C═O)R, and substituted or unsubstituted amino; and Rrepresents a group selected from hydrogen, C-Calkyl, aryl, and —OR, where Rand Rmay be linked to each other to form a ring with one or more carbon atoms constituting Ring Z. 2. The solvent according to for organic transistor production claim 1 ,wherein the solvent A comprises at least one selected from the group consisting of 2-methylcyclopentanone, 2-methylcyclohexanone, cyclohexyl methyl ether, cyclohexylamine, methoxybenzene, 1,2-dimethoxybenzene, 2,3-dihydrobenzofuran, and 2,3-dihydro-3-methylbenzofuran.6. A composition for organic transistor production claim 1 , the composition comprising:an organic semiconductor material; and{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the solvent according to for organic transistor production.'} The present invention relates to a solvent that is used for organic transistor production and has excellent solubility for organic semiconductor materials; and to a composition that is used for organic transistor production and includes an organic semiconductor material and the solvent for organic transistor production. The present application claims priority to Japanese Patent Application No. 2013-241096 filed to Japan Nov. 21, 2013, the entire contents of which are incorporated herein by reference.Organic transistors are widely used as principal semiconductor electronic devices constituting displays and computer ...

METHOD FOR PRODUCING KETONE AND/OR ALCOHOL, AND SYSTEM THEREOF

A method and a system for inexpensively producing a corresponding target ketone and/or alcohol by decomposing hydroperoxide rapidly and with high selectivity using an aqueous alkaline solution and by recovering and recycling alkali. The method includes neutralizing at least a part of a carboxylic acid in the oxidation reaction solution by contacting the oxidation reaction solution with a first alkaline solution including a carbonate of an alkali metal, and separating the reaction mixture into a first oil phase and a first water phase; decomposing the hydroperoxide and the ester compound in the first oil phase by contacting the first oil phase with a second alkaline solution having a higher pH value than the first alkaline solution, and separating the reaction mixture into a second oil phase and a second water phase; and recovering the carbonate of an alkali metal from the first water phase and recycling the carbonate of an alkali metal to the first alkaline solution. 1. A method for producing a ketone and/or alcohol by decomposing a hydroperoxide and an ester compound in an oxidation reaction solution obtained from oxidizing a hydrocarbon compound with molecular oxygen , in which the ketone and/or alcohol has the same number of carbon atoms as the hydrocarbon compound; wherein the method comprises:neutralizing at least a part of a carboxylic acid in the oxidation reaction solution by contacting the oxidation reaction solution with a first alkaline solution comprising a carbonate of an alkali metal, and separating the reaction mixture into a first oil phase and a first water phase;decomposing the hydroperoxide and the ester compound in the first oil phase by contacting the first oil phase with a second alkaline solution having a higher pH value than the first alkaline solution, and separating the reaction mixture into a second oil phase and a second water phase;recovering at least a part of an unreacted hydrocarbon from the second oil phase;obtaining the ketone and/ ...

Method for Synthesising Cyclohexenones and the Use of Same in the Perfume Industry

The present invention concerns a method for synthesising cyclohexenone and cyclohexenol compounds having specific fragrances and remanence properties, said method consisting in condensing a ketone on an α-methylene-aldehyde in order to obtain, by means of a domino reaction, compounds of formula (I).

A Process for Revamping a Plant for the Production of Cyclohexanone

A process for the construction of a second chemical plant, which second chemical plant is suitable for the separation of cyclohexanone from a second mixture, which second mixture comprises reaction products from the hydrogenation of phenol, said process comprising: a) providing a first chemical plant, which first chemical plant is suitable for the separation of cyclohexanone from a first mixture, which first mixture comprises reaction products from the oxidation of cyclohexane, and which first plant comprises: i) a distillation column (C) suitable for distilling overhead cyclohexane; ii) a distillation column suitable for distilling overhead cyclohexanone; iii) a cyclohexane oxidation unit (A) suitable for the oxidation of cyclohexane; and iv) a heat recovery unit (B) suitable for the recovery of heat from off-gas from the cyclohexane oxidation unit suitable for the oxidation of cyclohexane; b) disabling in said first chemical plant, said distillation column (C) suitable for distilling overhead cyclohexane, said cyclohexane oxidation unit (A) and said heat recovery unit (B), wherein the second chemical plant comprises a distillation column (F) suitable for distilling overhead cyclohexanone reused from the first chemical plant, wherein each of the first chemical plant and the second chemical plant comprise a distillation column (E) suitable for distilling overhead components having a lower boiling point than cyclohexanone; a distillation column (G) suitable for distilling overhead a mixture comprising cyclohexanol and cyclohexanone in a wt.:wt. ratio of at least 4:1; and a cyclohexanol dehydrogenation unit (H) suitable for the dehydrogenation of cyclohexanol to cyclohexanone. 115.-. (canceled)16. A process for the construction of a second chemical plant , which second chemical plant is suitable for the separation of cyclohexanone from a second mixture , which second mixture comprises reaction products from the hydrogenation of phenol , said process comprising:a) ...

Process for separating a mixture comprising cyclohexanone and phenol

In a process for separating a mixture comprising cyclohexanone and phenol, at least a portion of the mixture is distilled in the presence of a solvent including at least two alcoholic hydroxyl groups attached to non-adjacent saturated carbon atoms, water, and in the presence or absence of a hemiketal defined by the formula (I) or the formula (II): wherein R 1 , the same or different at each occurrence, is independently an alkylene group having from 2 to 10 carbon atoms, R 2 is an alkylene group having from 4 to 10 carbon atoms and/or R 3 is hydrogen or the following group: and in the presence or absence of an enol-ether derived from the hemiketal defined by the formula (I) or the formula (II), wherein the total concentration of the hemiketal and enol-ether, expressed in term of weight percentage of the total weight of the feed to the distilling step, is at most 0.01%.

Microencapsulated catalyst methods of preparation and method of use thereof

A microencapsulated catalyst is prepared by dissolving or dispersing a catalyst in a first phase (for example an organic phase), dispersing the first phase in a second, continuous phase (for example an aqueous phase) to form an emulsion, reacting one or more microcapsule wall-forming materials at the interface between the dispersed first phase and the continuous second phase to form a microcapsule polymer shell encapsulating the dispersed first phase core and optionally recovering the microcapsules from the continuous phase. The catalyst is preferably a transition metal catalyst and the encapsulated catalyst may be used for conventional catalysed reactions. The encapsulated catalyst may recovered from the reaction medium and re-cycled.

减少含有环己烯酮的有机混合物中的环己烯酮含量的方法

本发明公开了一种降低含环己烯酮有机混合物中的环己烯酮的浓度的方法，该方法包括使含有环己烯酮的有机混合物与有效量的至少一种亚硫酸、亚硫酸的盐、碱金属氢氧化物或这些化合物中的两种或多种的混合物接触。

Method of acylated diketonic compounds preparation

An acylated diketonic compound is produced by rearrangement of the corresponding enol ester in the presence of a cyanide source. In one embodiment the cyanide source is employed with a molar excess of a moderate base, with respect to the enol ester. In another embodiment, the cyanide source is a stoichiometric amount, with respect to the enol ester, of potassium or lithium cyanide and a catalytic amount of a Crown ether is used.

Dehydrogenation catalyst and process

A catalyst composition comprises (i) a support; (ii) a dehydrogenation component comprising at least one metal or compound thereof selected from Groups 6 to 10 of the Periodic Table of Elements; and (iii) potassium or a potassium compound present in an amount of about 0.15 to about 0.6 wt % of potassium based upon the total weight of the catalyst composition, wherein the catalyst composition has an oxygen chemisorption of greater than 50%.

Process and system for making cyclohexanone

Disclosed are processes and systems for making cyclohexanone from a mixture comprising phenol, cyclohexanone, and cyclohexylbenzene, comprising a step of or a device for subjecting at least a portion of the mixture to hydrogenation and a step of or a device for distilling a phenol/cyclohexanone/cyclohexylbenzene mixture to obtain an effluent rich in cyclohexanone.

Process and system for making cyclohexanone

Disclosed are processes and systems for making cyclohexanone from a mixture comprising phenol, cyclohexanone, and cyclohexylbenzene, comprising a step of or a device for subjecting at least a portion of the mixture to hydrogenation and a step of or a device for distilling a phenol/cyclohexanone/cyclohexylbenzene mixture to obtain an effluent rich in cyclohexanone.

Process and system for making cyclohexanone

Disclosed are processes and systems for making cyclohexanone from a mixture comprising phenol, cyclohexanone, and cyclohexylbenzene comprising a step of or a device for subjecting at least a portion of the mixture to hydrogenation and a step of or a device for distilling a phenol/cyclohexanone/cyclohexylbenzene mixture to obtain an effluent rich in cyclohexanone.

Process for making cyclohexanone

Disclosed are processes for making cyclohexanone from a mixture comprising phenol, cyclohexanone, cyclohexylbenzene, and an S-containing component, comprising a step of removing at least a portion of the S-containing component to reduce poisoning of a hydrogenation catalyst used for hydrogenating phenol to cyclohexanone.

PROCESS FOR CLEANING CYCLOHEXANONE

Process for producing phenol and/or cyclohexanone

In a process for producing phenol and/or cyclohexanone, benzene and hydrogen are contacted with a first catalyst in a hydroalkylation step to produce a first effluent stream comprising cyclohexylbenzene, cyclohexane, and unreacted benzene. At least part of the first effluent stream is supplied to a first separation system to divide the first effluent stream part into a cyclohexylbenzene-rich stream and a C6 product stream comprising unreacted benzene and cyclohexane.

Process for producing phenol

In a process for producing phenol, cyclohexylbenzene is oxidized to produce cyclohexylbenzene hydroperoxide and then the resultant cyclohexylbenzene hydroperoxide is cleaved to produce an effluent stream comprising phenol and cyclohexanone. At least a portion of the effluent stream is then fed to at least one dehydrogenation reaction zone, where the effluent stream portion is contacted with a dehydrogenation catalyst under conditions effective to convert at least part of the cyclohexanone in the effluent portion into phenol and hydrogen.

Oxidation process

Process for the production of cyclohexanone from phenol

본 발명은 페놀 및 수소로부터 사이클로헥산온을 생산 및 회수하기 위한 산업 규모의 연속 공정에 관한 것으로, 상기 공정은, 페놀 수소화 반응기에서 페놀을 수소화하는 단계; 및 적어도 4개의 증류 섹션을 포함하는 분리 및 정제 섹션[II]에서 수소화된 생성물 스트림으로부터 사이클로헥산온을 분리하는 단계를 포함하고; 페놀 수소화 반응 섹션[I]에서 생성되는 반응열의 적어도 일부는 스팀의 생산에 적용되며; 상기 페놀 수소화 반응기에 충전되는 페놀에 대한 사이클로헥산온의 몰비는 0.02 내지 0.10 이고/이거나; 상기 페놀 수소화 반응기에 충전되는 페놀에 대한 사이클로헥산올의 몰비는 0.001 내지 0.10 이다.

Catalysts for oxidising cycloalkanes and method of producing alcohols and ketones

FIELD: chemistry. SUBSTANCE: present invention relates to a method of oxidising cycloalkane with formation of a mixture of products containing the corresponding alcohol and ketone, said method comprising bringing cycloalkane into contact with a hydroperoxide compound in the presence of at least a cerium oxide-based catalyst. EFFECT: disclosed method enables to achieve high selectivity relative to end products with good combination of degree of conversion and yield. 7 cl, 12 tbl, 105 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 707 291 C2 (51) МПК C07C 29/48 (2006.01) C07C 45/28 (2006.01) C07C 35/08 (2006.01) C07C 49/303 (2006.01) B01J 23/10 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07C 29/48 (2019.08); C07C 45/28 (2019.08); B01J 23/10 (2019.08) (21)(22) Заявка: 2017126074, 18.12.2015 (24) Дата начала отсчета срока действия патента: Дата регистрации: 26.11.2019 (73) Патентообладатель(и): РОДИА ОПЕРАСЬОН (FR) 22.12.2014 EP 14290400.2 (43) Дата публикации заявки: 24.01.2019 Бюл. № 3 (45) Опубликовано: 26.11.2019 Бюл. № 33 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 24.07.2017 (56) Список документов, цитированных в отчете о поиске: US 6995233 B2, 07.02.2006. WO 2014015491 A1, 30.01.2014. EP 1518849 A1, 30.03.2005. US 2439513 A, 13.04.1948. RU 2233830 C2, 10.08.2004.. 2 7 0 7 2 9 1 Приоритет(ы): (30) Конвенционный приоритет: R U 18.12.2015 (72) Автор(ы): ШУЗЬЕ, Сандра (FR), ОКАМПО, Фабьен (FR), МАСТРОЯННИ, Серджо (FR), КОРМА, Авелино (ES), БОРОНАТ, Мерседес (ES), ЛОПЕС АУСЕНС, Хавьер Тирсо (ES) EP 2015/080410 (18.12.2015) C 2 C 2 (86) Заявка PCT: (87) Публикация заявки PCT: R U 2 7 0 7 2 9 1 WO 2016/102343 (30.06.2016) Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, стр. 3, ООО "Юридическая фирма Городисский и Партнеры" (54) КАТАЛИЗАТОРЫ ОКИСЛЕНИЯ ЦИКЛОАЛКАНОВ И СПОСОБ ПОЛУЧЕНИЯ СПИРТОВ И КЕТОНОВ (57) Реферат: Настоящее изобретение относится к способу по меньшей мере ...

Method of obtaining benzilaminoalkane acids or salts thereof

Cycloalkane oxidation catalysts and method to produce alcohols and ketones

사이클로알칸을 상응하는 알코올 및 케톤이 함유된 생성물 혼합물로 산화시키는 방법을 개시하며, 상기 방법은 사이클로알칸을 촉매 유효량의 결정성 MWW-유형 규산티타늄 촉매의 존재 하에 하이드로퍼옥사이드와 접촉시키는 단계를 포함한다. 하이드로퍼옥사이드는 특히 tert-부틸 하이드로퍼옥사이드, tert-아밀 하이드로퍼옥사이드, 쿠멘 하이드로퍼옥사이드, 에틸벤젠 하이드로퍼옥사이드, 사이클로헥실 하이드로퍼옥사이드, 메틸사이클로헥실 하이드로퍼옥사이드, 테트랄린 하이드로퍼옥사이드, 이소부틸벤젠 하이드로퍼옥사이드, 및 에틸나프탈렌 하이드로퍼옥사이드일 수 있다. Which process comprises contacting a cycloalkane with a hydroperoxide in the presence of a catalytically effective amount of a crystalline MWW-type titanium silicate catalyst, the process comprising contacting the cycloalkane with a product mixture containing a corresponding alcohol and ketone do. Hydroperoxides are especially preferred for use in the process of the present invention, such as tert-butyl hydroperoxide, tert-amyl hydroperoxide, cumene hydroperoxide, ethylbenzene hydroperoxide, cyclohexyl hydroperoxide, methylcyclohexyl hydroperoxide, Isobutyl benzene hydroperoxide, and ethyl naphthalene hydroperoxide.

Process for producing phenol and/or cyclohexanone

페놀 및/또는 사이클로헥사논의 제조방법에서, 벤젠 및 수소를 하이드로알킬화 단계에서 제 1 촉매와 접촉시켜 사이클로헥실벤젠, 사이클로헥산 및 미반응된 벤젠을 포함하는 제 1 유출물 스트림을 생성한다. 상기 제 1 유출물 스트림의 적어도 일부를 제 1 분리 시스템에 공급하여 상기 제 1 유출물 스트림 부분을 사이클로헥실벤젠-풍부 스트림과 미반응된 벤젠 및 사이클로헥산을 포함하는 C 6 생성물 스트림으로 나눈다. In the process for preparing phenol and / or cyclohexanone, benzene and hydrogen are contacted with a first catalyst in a hydroalkylation step to produce a first effluent stream comprising cyclohexylbenzene, cyclohexane and unreacted benzene. At least a portion of the first effluent stream is fed to a first separation system to divide the first effluent stream portion into a C 6 product stream comprising a cyclohexylbenzene-rich stream and unreacted benzene and cyclohexane.

METHOD FOR SYNTHESIS OF CYCLOGHEXENONES AND THEIR APPLICATION IN PERFUMES

1. Способ получения соединения формулы (I):,где - R1 представляет собой метил или этил;- R2 независимо представляет собой атом водорода или С1-С5-алкил или С2-С5-алкенил;- R3 представляет собой алкил или алкенил, необязательно замещенный арилом, или R3 представляет собой циклический алкил или циклический алкенил, необязательно замещенный одним или несколькими С1-С6-алкилами, при условии, что R3 содержит суммарно от 3 до 10 атомов углерода;- Z представляет собой С(О) или CR4(OR5), где:- R4 представляет собой атом водорода или С1-С8-алкил или С2-С8-алкенил;- R5 представляет собой атом водорода или С1-С8 алкил или алканоил или С2-С8алкенил или алкеноил;с учетом того, что двойная связь в цикле присутствует или отсутствует, и что, когда она присутствует, она находится:- или в положении 2-3, и R2 отсутствует в положении 2;- или в положении 3-4, и R2 присутствует в положении 2 и имеет определенные ранее значения;отличающийся тем, что в указанный способ включает следующие стадии:i) реакцию α-метиленальдегида в присутствии основания с симметричным кетоном с получением соединения формулы (Ia):,где R1 и R3 имеют определенные ранее значения, R2 представляет собой атом водорода, и в положении 2-3 или 3-4 цикла имеется двойная связь, причем после этой реакции необязательно следуют стадии ii), и/или iii), и/или iv);ii) реакцию моно- или бис-алкилирования для получения соединения формулы (1а), в которой R2 представляет собой С1-С5-алкил или С2-С5-алкенил;iii) конверсии функциональной группы Z=C(O) соединения, полученного на предыдущей стадии, в функциональную группу Z=CR4(OR5), в которой R4 и R5 имеют значения, определенные ранее;iv) восстановления двойной связи, находящейся в положении 2-3 или 3-4 в цикле соединения, полученного на предыдущей стадии, причем стадия iv) может быть осуществлена после РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК C07C 29/20 (13) 2015 116 505 A (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: ...

Method for the preparation of cyclohexanone

본 발명은 시클로헥산으로부터 시클로헥사논을 제조하는 방법에 관한 것이다. 본 발명은 더욱 특히 불순물 함량을, ε-카프로락탐의 제조용 원료로서 시클로헥사논을 사용할 수 있게 할 정도로 갖는 시클로헥산의 제조 방법에 관한 것이다. 본 발명의 방법은 시클로헥사놀을 시클로헥사논으로 전환시키기 위한 탈수소화 단계에서 산소에 의한 시클로헥산의 산화에 의해 생성되는 시클로헥사놀/시클로헥사논 혼합물, 및 시클로펜테날과 같은 존재하는 불순물의 처리로 이루어진다. 본 발명의 방법은 ε-카프로락탐을 합성하기 위한 원료로서 사용될 때 상용성인 고순도의 시클로헥사논의 수득을 가능하게 한다. The present invention relates to a process for preparing cyclohexanone from cyclohexane. The present invention more particularly relates to a method for producing cyclohexane having an impurity content such that cyclohexanone can be used as a raw material for producing ε-caprolactam. The process of the present invention provides a process for the presence of impurities such as cyclohexanol / cyclohexanone mixtures produced by oxidation of cyclohexane with oxygen in the dehydrogenation step for converting cyclohexanol to cyclohexanone, and cyclopentenal. Processing takes place. The process of the present invention makes it possible to obtain high purity cyclohexanone which is compatible when used as raw material for synthesizing epsilon -caprolactam. 시클로헥사놀, 시클로헥산, ε-카프로락탐 Cyclohexanol, cyclohexane, ε-caprolactam

Method for producing cyclohexanone dimer

사이클로헥사논 이량체를 제조하는 방법이 제공된다. 이 방법은 고체산 촉매의 존재하에서 사이클로헥사논의 축합을 수행하여 사이클로헥사논 이량체를 수득하는 단계를 포함하고, 고체산 촉매는 텅스텐의 금속 산화물과 루이스산 부위 및 브뢴스테드산 부위를 가지는 담체를 포함한다. 본 개시의 방법은 온화한 반응 조건, 빠른 반응 속도 및 높은 선택성의 이점을 가지므로, 산업상 응용 가치를 실현할 수 있다. Methods for preparing cyclohexanone dimers are provided. The method comprises the step of carrying out condensation of cyclohexanone in the presence of a solid acid catalyst to obtain a cyclohexanone dimer, wherein the solid acid catalyst is a metal oxide of tungsten and a carrier having a Lewis acid site and a Bronsted acid site includes Since the method of the present disclosure has the advantages of mild reaction conditions, fast reaction rate and high selectivity, it can realize industrial application value.

Novel 4-cyclohexylacetophenone compound

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Process for the preparation of 3,4,5,7,8,9-hexahydro-2H-dibenzofuran-1-on, and 1-hydroxydibenzofuran and 4-hydroxycarbazole with 3,4,5,7,8,9-hexahydro-2H-dibenzofuran-1-on being a intermadiate

3,4,5,7,8,9-헥사히드로-2H-디벤조퓨란-1-온, 및 이를 중간체로 하는 1-히드록시디벤조퓨란(1-hydroxy dibenzofuran)과 4-히드록시카바졸(4-Hydroxycarbazole)의 제조 방법이 개시된다. 2-클로로사이클로헥산온과 1,3-사이클로헥산디온을 염기 및 유기용매 하에서 반응시켜 탄소-탄소 결합을 형성시킨 후, 산 용액의 존재 하에서 상기 반응물을 고리화 반응시켜 3,4,5,7,8,9-헥사히드로-2H-디벤조퓨란-1-온을 제조하고, 이를 중간체로 하여 질소치환 반응 및 탈수소화 반응을 거쳐 4-히드록시카바졸을 제조한다. 한편, 1-히드록시디벤조퓨란은 3,4,5,7,8,9-헥사히드로-2H-디벤조퓨란-1-온을 탈수소화시킴으로서 얻을 수 있다. 본 발명에 따른 3,4,5,7,8,9-헥사히드로-2H-디벤조퓨란-1-온, 및 이를 중간체로 하는 1-히드록시디벤조퓨란(1-hydroxy dibenzofuran)과 4-히드록시카바졸의 제조 방법은 저가의 출발 물질을 사용함으로써 경제성을 높이고, 특정 염기 및 유기용매 조건에서 반응이 안정하며, 산 용액의 존재하에 일어나는 고리화 반응으로 인해 고수율의 3,4,5,7,8,9-헥사히드로-2H-디벤조퓨란-1-온이 생성된다. 또한, 이러한 중간체를 이용하여 보다 안정하고 경제적으로 1-히드록시디벤조퓨란과 4-히드록시카바졸을 제조할 수 있다. 3,4,5,7,8,9-hexahydro-2H-dibenzofuran-1-one, and 1-hydroxydibenzofuran and 4-hydroxycarbazole having the intermediate thereof A method for preparing (4-Hydroxycarbazole) is disclosed. 2-chlorocyclohexanone is reacted with 1,3-cyclohexanedione in a base and an organic solvent to form a carbon-carbon bond, and then the reaction is cyclized in the presence of an acid solution to give 3,4,5,7 , 8,9-hexahydro-2H-dibenzofuran-1-one is prepared, and 4-hydroxycarbazole is prepared through nitrogen substitution and dehydrogenation as an intermediate. On the other hand, 1-hydroxydibenzofuran can be obtained by dehydrogenating 3,4,5,7,8,9-hexahydro-2H-dibenzofuran-1-one. 3,4,5,7,8,9-hexahydro-2H-dibenzofuran-1-one according to the present invention, and 1-hydroxy dibenzofuran and 4- as intermediates thereof The process for preparing hydroxycarbazole increases the economics by using inexpensive starting materials, the reaction is stable under certain base and organic solvent conditions, and high yield of 3,4,5 due to the cyclization reaction occurring in the presence of an acid solution. , 7,8,9-hexahydro-2H-dibenzofuran-1-one is produced. In addition, these intermediates can be used to prepare 1-hydroxydibenzofuran and 4-hydroxycarbazole more stably and economically. 3,4,5,7,8,9-헥사히드로-2H-디벤조퓨란-1-온, 1-히드록시디벤조퓨란, ...

Process for the preparation of 2-(1-(oxyamino)-alkylidene)cyclohexane-1,3-diones

The title compds. of formula (I) are new. (I) are prepd. by reacting (II) with H2NOR1 or its salt in the presence of org. amine and alk. metal carbonate (for the elimination of generating hydrogen-halide). R=C1-6 alkyl or phenyl; R1=substd. benzyl; R2 and R3 are H, C1-3 alkyl or alkylthio, C2-8 alkylthioalkyl independently; R4=H or C2-4 carbalkoxy; R5=H, NH4+, Na+, Ca2+ or -C(=0)-R6; R6=C1-6 alkyl or C6-10 aryl. (I) are useful as grassy herbicide(before or after ger mination).

Hydrogenation process

본 발명은 페놀의 제조와 관련하여 이용될 수 있는 수소화 공정에 관한 것이다. 이 공정에서는, (i) 시클로헥실벤젠, 및 (ii) 수소화 가능한 성분을 포함하는 조성물이 수소화 촉매의 존재 하에 수소화 조건에서 수소와 접촉하게 된다. 그 수소화 가능한 성분은 올레핀, 케톤 또는 페놀 중 하나 이상일 수 있다. 그 수소화 촉매는 수소화 성분 및 지지체를 보유한다. The present invention relates to a hydrogenation process which can be used in connection with the production of phenols. In this process, a composition comprising (i) cyclohexylbenzene, and (ii) a hydrogenatable component is brought into contact with hydrogen under hydrogenation conditions in the presence of a hydrogenation catalyst. The hydrogenatable component can be at least one of an olefin, a ketone or a phenol. The hydrogenation catalyst has a hydrogenation component and a support.

Fragrance composition

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Catalyst composition, and use of the same

팔라듐(Pd) 및 란탄트리플레이트[Ln(OTf) 3 ]를 포함하는 페놀의 수소화 환원용 촉매 조성물, 및 상기 촉매 조성물 및 용매의 존재 하에서 페놀을 수소와 반응시켜 사이클로헥사논(cyclohexanone)을 형성하는 단계를 포함하는 사이클로헥사논의 제조 방법에 관한 것이다. A catalyst composition for the hydrogenation reduction of phenol comprising palladium (Pd) and lanthanum triplate [Ln (OTf) 3 ], and reacting phenol with hydrogen in the presence of the catalyst composition and a solvent to form cyclohexanone It relates to a method for producing cyclohexanone comprising the step.

Derivatives of glyoxyl-cyclohexenedione, method of their synthesis, herbicide composition, method of weed inhibition

FIELD: organic chemistry. SUBSTANCE: invention proposes compounds of the formula (I): $$$ which were used as herbicides exhibiting effect with respect to dicotyledonous weed, methods of their synthesis and using. EFFECT: improved method of synthesis, enhanced effectiveness of herbicides. 6 cl, 4 tbl ЭУ5 ООС ПЫ Го (19) РИ (11) 2 100 346 (13) Сл ОМК © 07С 49/603, 49/172, 49/175, А 01 М 35/06 РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 4830743/04, 19.07.1990 (71) Заявитель: Шелл Интернэшнл Рисерч Маатсхаппий Б.В. (30) Приоритет: 21.07.1989 ОЕ Р 39242412 (МЫ) (46) Дата публикации: 27.12.1997 (72) Изобретатель: Ханс Иоахим Биссингер[ОЕ], | Людвиг Шредер[ОЕ], Хельмут 49/784, 1987. 2. ЗИ, патент, 1209016, кл. А Фрусторфер[ОЕ] Манфред Гарех ОЕ] 01 М 31/06, 1982. () (73) Патентообладатель: Шелл Интернэшнл Рисерч Маатсхаппий Б.В. (Ме) < (54) ПРОИЗВОДНЫЕ ГЛИОКСИЛ-ЦИКЛОГЕКСЕНДИОНА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ГЕРБИЦИДНАЯ < КОМПОЗИЦИЯ, СПОСОБ ПОДАВЛЕНИЯ НЕЖЕЛАТЕЛЬНОГО РОСТА РАСТЕНИЙ < (57) Реферат: которые находят использование в © Предложены соединения формулы 1: качестве гербицидов, эффективных против двудольных сорняков, способы их получения © и использования. 5 з.п. ф-лы, 4 табл. == Сс' — О Эт 0О0б0гс ПЧ Го (19) КУЗЗАМ АСЕМСУ ГОК РАТЕМТ$ АМО ТКАОЕМАКК$ 12) АВЗТКАСТ ОЕ 1МУЕМТОМ ВИ “” 2400 346 ' (51) 1пЕ. С1.6 13) Сл С 07С 49/603, 49/172, 49/175, А 01 М 35/06 (21), (22) АррИсаНоп: 4830743/04, 19.07.1990 (30) Рпогйу: 21.07.1989 ОЕ Р 3924241.2 (46) Рае ог рибИсаНоп: 27.12.1997 (72) |пуетог: (71) АррИсапе: эре! |егпейзпп! Кизегсй МааКварри В.М. (МЕ) КПап$ 1оакКМт Вззтаег[ОЕ], Циама эпгедегоЕ], Кпе’тще ВаЧгизпа ОЕ], ЕПК Кадда [ОЕ], Мо Чдапа ЕгиЗогег[ОЕ], Маптеа Сагекп ОЕ] (73) Ргорпеюг: эпе! \егпейзйп! К зегсй МааКПарри В.М. (МЕ) (54) РДЕКМАТМЕЗ$З ОЕ СЕУОХУЕ-СУСЕОНЕХЕМЕОЮМЕ, МЕТНОО ОЕ ТНЕКВ ЗУМТНЕ$!$, НЕКВСТОЕ СОМРОЗГОМ, МЕТНОО ОЕ \МЕЕО 1МНВГОМ (57) АБЗгасЕ: НЕГО: огдапс спептгу. ЗОВЗТАМСЕ: пуепНоп ...

Method for reducing cyclohexenone content of a cyclohexenone-containing organic mixture

本发明公开了一种降低含环己烯酮有机混合物中的环己烯酮的浓度的方法，该方法包括使含有环己烯酮的有机混合物与有效量的至少一种亚硫酸、亚硫酸的盐、碱金属氢氧化物或这些化合物中的两种或多种的混合物接触。

Cycloalkane oxidation catalysts and method to produce alcohols and ketones

본 발명은 사이클로알칸을 산화시켜 상응하는 알코올 및 케톤을 포함하는 생성물 혼합물을 형성하는 방법에 관한 것이며, 상기 방법은 금속 트리플레이트 또는 금속 트리플미데이트 촉매의 촉매 유효량의 존재 하에서 사이클로알칸을 산화제와 접촉시키는 단계를 포함한다. The present invention relates to a method for oxidizing a cycloalkane to form a product mixture comprising the corresponding alcohol and ketone, the method comprising contacting a cycloalkane with an oxidizing agent in the presence of a catalytically effective amount of a metal triflate or metal trifamide catalyst. It includes the step of making.

Branched amides of L-aspartyl-D-amino acid dipeptides

Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein R a is CH 2 OH or CH 2 OCH 3 ; R is a branched member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethyl-t-butylcarbinyl, di-t-butyl-carbinyl, 2-methylthio-2,4-dimethylpentan-3-yl, ##STR2## said amides are potent sweeteners having advantages over the prior art, edible compositions containing them, methods for their use in edible compositions and novel amide intermediates useful in their production.

Method for producing optically active ketone

Perfume composition containing an alkyl cyclohexanone

Hydrogenation process

STABILIZED COMPOSITIONS BASED ON POLYVINYL CHLORIDE

PROCESS FOR THE SYNTHESIS OF CYCLOHEXENONES AND THEIR USE IN PERFUMERY

PROCESS FOR THE PREPARATION OF (3R, 3'R) -ZEAXANTHENE

FOERFARANDE FOER FRAMSTAELLNING AV ACYLERADE DIKETONFOERENINGAR.

Patent FR2303798B1

NEW SUBSTITUTE CYCLOHEXANES USEFUL AS OLFACTORY AGENTS

L'invention concerne des composés chimiques nouveaux. Il s'agit des composés de formule : The invention relates to novel chemical compounds. These are compounds of formula:

PROCESS FOR THE SYNTHESIS OF CYCLOHEXENONES AND THEIR USE IN PERFUMERY

La présente invention se rapporte à un procédé de synthèse de composés cyclohexènones et cyclohexènols présentant des fragrances et des propriétés de rémanence particulières, ledit procédé consistant en la condensation d'une cétone sur un α-méthylène-aldéhyde afin d'obtenir par une réaction domino, des composés de formule (I) suivante : The present invention relates to a process for the synthesis of cyclohexenone and cyclohexenols compounds having particular fragrances and remanence properties, said process consisting of the condensation of a ketone on an α-methylene-aldehyde to obtain by a domino reaction compounds of formula (I) below:

PROCESS FOR THE PREPARATION OF CYCLOHEXANONE

Elle concerne plus particulièrement un procédé de préparation de cyclohexanone présentant une teneur en impuretés permettant une utilisation de la cyclohexanone comme matière première pour la fabrication d'ε-caprolactame.Le procédé de l'invention comprend notamment un traitement du mélange cyclohexanol/cyclohexanone issu de l'oxydation par l'oxygène du cyclohexane dans une étape de déshydrogénation pour transformer le cyclohexanol en cyclohexanone et les impuretés présentes telles que le cyclopentènal. Le procédé de l'invention permet d'obtenir une cyclohexanone présentant un degré de pureté élevé, compatible pour son utilisation comme matière première dans la synthèse de l'ε-caprolactame. It relates more particularly to a process for the preparation of cyclohexanone having an impurity content allowing a use of cyclohexanone as raw material for the manufacture of ε-caprolactam.The process of the invention comprises in particular a treatment of the cyclohexanol / cyclohexanone mixture from oxygen oxidation of cyclohexane in a dehydrogenation step to convert cyclohexanol to cyclohexanone and the impurities present such as cyclopentenal. The process of the invention makes it possible to obtain a cyclohexanone having a high degree of purity compatible for use as a raw material in the synthesis of ε-caprolactam.

PROCESS FOR THE PREPARATION OF CYCLOHEXANONE

Process for Dehydrogenating Secondary Cyclic Alcohols

본 발명은 2차 고리형 알콜을 사용하여 수소, 및 활성 성분으로 30 내지 60 중량 %의 산화 아연 및 40 내지 70 중량 %의 방해석 변형태로의 탄산 칼슘을 포함하는 촉매의 존재하에서 탈수소 반응을 수행하는, 2차 알콜의, 승온하에 산화 아연 및 탄산 칼슘을 포함하는 촉매의 존재하의 기체상 탈수소화에 관한 것이다. 또한 본 발명은 탈수소화 촉매, 그의 제조 방법 및 그의 용도에 관한 것이다.

Patent FR2303797B1

Patent FR2303786B1

4,4,5,8-Tetramethyl-1-oxaspiro(2.5) octane, process for its preparation and its use as a starting material in the preparation of 2,2,3,6-tetramethyl cyclohexane carboxaldehyde

Improvements to processes for the production of dicarbonyl compounds

CICLOHEXANONA PREPARATION PROCEDURE.

Un procedimiento de fabricación de ciclohexanona, caracterizado porque comprende las etapas siguientes: - Oxidar la ciclohexanona a hidroperóxido de ciclohexilo por medio de oxígeno en ausencia de catalizador - Purificar el medio de reacción mediante lavado con agua - Descomponer el hidroperóxido de ciclohexilo en ciclohexanol y ciclohexanona en presencia de un catalizador - Recuperar la mezcla ciclohexanol/ciclohexanona por separación del ciclohexano que no ha reaccionado y separación de los productos de punto de ebullición más elevado que los del ciclohexanol/ciclohexanona- Deshidrogenar el ciclohexanol contenido en la mezcla ciclohexanol/ciclohexanona en presencia de un catalizador de deshidrogenación- Destilar, en una primera etapa de destilación, la mezcla obtenida para obtener una fracción de cabeza (F1), que comprende los compuestos de punto de ebullición inferior a la temperatura de ebullición de la ciclohexanona, y una fracción de cola (Q1)- Destilar, en una segunda etapa de destilación, la fracción de cola (Q1) para obtener una fracción de cabeza (F2), constituida por la ciclohexanona, y una fracción de cola (Q2) A manufacturing process of cyclohexanone, characterized in that it comprises the following steps: - Oxidizing cyclohexanone to cyclohexyl hydroperoxide by means of oxygen in the absence of a catalyst - Purifying the reaction medium by washing with water - Decomposing cyclohexyl hydroperoxide into cyclohexanol and cyclohexanone in the presence of a catalyst - Recover the cyclohexanol / cyclohexanone mixture by separating the unreacted cyclohexane and separating the boiling products higher than those of the cyclohexanol / cyclohexanone- Dehydrogenating the cyclohexanol contained in the cyclohexanol / cyclohexanone mixture in the presence of a dehydrogenation catalyst- Distill, in a first distillation stage, the mixture obtained to obtain a head fraction (F1), which comprises the boiling point compounds below the boiling temperature of the ...

Method for the dehydration of secondary cyclic alcohols

Stabilisation of vinyl chloride polymr compositions

Process for the preparation of cyclohexanol and cyclohexanone

본 발명은 레이니 니켈 촉매의 존재 하에서 시클로헥산 내의 시클로헥실 히드로퍼옥사이드를 수소화하여 시클로헥산올 및 시클로헥사논을 제공하는 단계를 포함하는, 시클로헥산올 및 시클로헥사논을 함유하는 혼합물의 제조 방법에 관한 것이다.

"4,4,5,8-Tetramethyl-1-oxaspiro [2.5] octane, a method for preparing the same, and 2,2,3,6-tetramethyl-cyclohexane-carbaldehyde, a method for preparing the same"

Herbicidal substituted 2-(1-(oxyamino)-alkylidene)-cyclohexane-1,3-diones

Substituted 2-[1-(oxyamino)alkylidene]-cyclohexane-1,3-diones have herbicidal activity against grassy weeds.

Process for decomposing cyclohexylhdroperoxide

本发明涉及一种将环己基过氧化氢分解为环己酮的方法，所述方法包括：将含有环己基过氧化氢的有机进料溶液与碱的水溶液在不存在过渡金属催化剂的情况下混合，产生一种混合物，该混合物包括(i)水相和(ii)含环己酮和环己醇的有机相。

Improvements relating to the partial oxidation of hydrocarbons

A process for hydrolysing the reaction products formed by the partial oxidation with molecular oxygen of a hydrocarbon, e.g. cyclo alkanes such as cyclohexane, cyclo-octane, methyl cyclohexane and diethyl cyclo-octane and straight or branched chain aliphatic hydrocarbons such as pentane, hexane, and decane, in the presence of a boron compound capable of reacting with alcohols formed by the oxidation e.g. boric acid, meta boric acid, tetra boric acid and boron anhydride, comprises contacting a mixture comprising the oxidation products in at least 20% by weight of the hydrocarbon with an aqueous hydrolysis medium, e.g. boric acid solution. Solid boric acid may be separated from the hydrolysis mixture and recycled to the oxidation step, and the residual hydrolysis mixture separated into an organic phase and an aqueous phase, the aqueous phase preferably being recycled to the hydrolysis step, and the reaction products recovered from the organic phase. Examples show the production of cyclohexanol and cyclohexanone from the oxidation of cyclohexane in the presence of boric acid and subsequent hydrolysis of the boron compound formed in the reaction.

Patent JPS6126766B2

Process for producing phenol

In a process for producing phenol, cyclohexylbenzene is contacted with an oxygen-containing compound in the presence of an oxidation catalyst comprising a cyclic imide under oxidation conditions effective to produce a product comprising cyclohexylbenzene hydroperoxide and unreacted cyclic imide catalyst. Without removing all the unreacted cyclic imide catalyst, at least a portion of the product is contacted with an acidic molecular sieve under conditions effective to adsorb at least a portion of the unreacted cyclic imide and to convert at least part of the cyclohexylbenzene hydroperoxide in the product portion into phenol and cyclohexanone.

A kind of ultra high efficiency oxidation reaction apparatus and method preparing cyclohexanone by hexamethylene

本发明公开了一种由环己烷制备环己酮的超高效氧化反应新工艺，该工艺由进料系统、超高效塔式氧化反应器R‑1主反应器系统和反应尾气绿色处理系统构成。该环己烷氧化工艺以空气作为氧化介质，同时以氧化过程中排出的高温高压反应尾气作为一次加热热源，进入换热器H‑1放出热量，并将放出的热量用于加热常温环己烷原料，同时以溢出的反应产物作为二次加热热源，溢出的反应产物进入换热器H‑3，再次加热环己烷原料。本发明与传统的塔式鼓泡氧化反应工艺或搅拌釜式氧化反应工艺相比，反应效率、环己酮一次收率均有提高，吨环己酮产品综合能耗降低，综合生产成本降低，属于真正意义上的超高效的绿色氧化反应工艺。

Process for preparing cyclohexanone and cyclohexanol

本发明提供了制备环己酮和环己醇的方法，所述方法包括：(a)通过将有机溶液与第一水性碱溶液混合，中和所述有机溶液中存在的酸和/或二氧化碳，以形成包含第一水相和第一有机相的第一混合物，其中所述有机溶液还包含环己基过氧化氢，(b)将第一水相与第一有机相分离，(c)排出第一水相，(d)通过将所述第一有机相与第二水性碱溶液混合，分解所述第一有机相中存在的环己基过氧化氢，以形成包含第二水相和含有环己酮和环己醇的第二有机相，(e)将第二水相与第二有机相分离，(f)将所述经分离的第二水相的至少一部分供料给所述中和步骤(a)，其中所述方法还包括将第一水相的一部分供料给所述分解步骤，以使第一水相在25℃下测量的pH大于8.5。

Process for producing phenol and cyclohexanone

In a process for separating a mixture comprising cyclohexanone and phenol, at least a portion of the mixture is distilled in the presence of a solvent including at least two alcoholic hydroxyl groups attached to non-adjacent saturated carbon atoms and at least one hemiketal defined by the formula (I) or the formula (II): wherein R 1 , the same or different at each occurrence, is independently an alkylene group having from 2 to 10 carbon atoms, R 2 is an alkylene group having from 4 to 10 carbon atoms, and R 3 is hydrogen or the following group: and/or an enol-ether derived from the hemiketal defined by the formula (I) or the formula (II), wherein the total concentration of the hemiketal and the enol-ether, expressed in terms of weight percentage on the basis of the total weight of the feed to the distilling step (a), is at least 0.01%.

Process for the production of 2-acetyl-1, 3-diketones

Working-up of reaction mixtures containing cyclohexanol and cyclohexanone

A process for working up reaction mixtures containing cyclohexanol and cyclohexanone, which have been obtained by oxidizing cyclohexane with molecular oxygen or gases containing molecular oxygen, in the liquid phase, at from 130° to 200° C. under a pressure of from 5 to 25 bars, working-up being effected by treatment with aqueous solutions of an alkali metal hydroxide and/or alkali metal carbonate in two stages, the fresh aqueous alkali metal hydroxide and/or alkali metal carbonate solution being fed to the second stage and the separated-off spent alkali being brought into contact with fresh reaction mixture in the first stage. The treatment in the first stage is carried out in the presence of inert gases and the inert gases are separated off before the second stage.

Phenol compositions

Described herein are compositions having (a) at least 99 wt % phenol; and (b) 0.1 wppm to 1000 wppm of at least one of the following components: bicyclohexane, cyclohexylbenzene, methylcyclopentylbenzene, hydroxycyclohexanone, cyclohexenone, cyclohexanol, cyclohexanone, cyclohexanedione, benzoic acid, hexanal, and methycyclopentanone, wherein the wt % and wppm are based upon the total weight of the composition.

Substituent cyclohexander, for the production of fruit and vegetables for the production of oil

Supported ruthenium nanoparticle catalyst for CIS- dihydroxylation and oxidative cleavage of alkenes

2-benzoyl-1,3,5-cyclohexanetriones

Compounds of the formula <CHEM> wherein R is hydrogen; halogen; C1-C2 alkyl; C1-C2 alkoxy; nitro; cyano; C1-C2 haloalkyl; or R<a>SOn - wherein n is 0 or 2 and R<a> is C1-C2 alkyl, trifluoromethyl or difluoromethyl; or trifluoromethoxy or difluoromethoxy; R<1> is hydrogen or C1-C4 alkyl; R<2> is hydrogen or C1-C4 alkyl; or R<1> and R<2> together are C2-C5 alkylene; R<3> is C1-C4 alkyl; R<4> is C1-C4 alkyl; or R<3> and R<4> together are C2-C5 alkylene; R<5> and R<6> independently are (1) hydrogen; (2) halogen; (3) C1-C4 alkyl; (4) C1-C4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C1-C4 haloalkyl; (9) R<b>SOn - wherein n is the integer 0, 1 or 2; and R<b> is (a) C1-C4 alkyl; (b) C1-C4 alkyl substituted with halogen or cyano; (c) phenyl; or (d) benzyl; (10) -NR<c>R<d> wherein R<c> and R<d> independently are hydrogen or C1-C4 alkyl; (11) R<e>C(O)- wherein R<e> is C1-C4 alkyl or C1-C4 alkoxy; or (12) -SO2NR<c>R<d> wherein R<c> and R<d> are as defined; and (13) -N(R<c>)C(O)R<d> wherein R<c> and R<d> are as defined and their salts.

Process for producing acylated cyclic diketone derivatives

Ruthenium complexes and their uses in processes for formation and/or hydrogenation of esters, amides and derivatives thereof

The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to the novel uses of certain pyridine Ruthenium catalysts.

PINANOPYRAZOLE

Method and catalyst for dehydrogenation of secondary cyclic alcohols and method of production of such catalyst

FIELD: methods of dehydrogenation of secondary cyclic alcohols in presence of catalyst containing zinc and calcium carbonate at elevated temperature in gas phase where dehydrogenation is effected in presence of hydrogen. SUBSTANCE: active components of catalyst used for realization of this method include 30 to 60+ACU- of zinc oxide and 40 to 70+ACU- of calcium carbonate in calcite modification. Invention discloses also dehydrogenation catalyst and method of its +AFs-production. EFFECT: possibility of obtaining cyclic ketones, cyclohexanone in particular at higher selectivity and higher yield reducing to minimum formation of splitting and aromatic byproducts+ADs- enhanced strength of tablets at frontal and lateral compression, thus increasing intervals for replacement of catalyst. 14 cl, 2 tbl, 3 ex, 2 test ex УСС ПЧ сэ (19) РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ ВИ” 2181 624 ' (51) МПК? 13) С2 В 01 4 23/02, 23/06, 27/232, 37/03, С 07С 45/00, 49/403 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 98118915/04, 06.03.1997 (24) Дата начала действия патента: 06.03.1997 (30) Приоритет: 14.03.1996 ОЕ 196 09 954.4 (43) Дата публикации заявки: 20.07.2000 (46) Дата публикации: 27.04.2002 (56) Ссылки: Спетеса! АБЗасЁ $, уо|!. 121, №22, 28.11.1994. ЗЦ 373922 А, 22.06.1973. Спептса! АБЗгас$, мо! Ш, №14, 02.10.1989. СВ 1054617 А, 11.01.1967. ОЕ 2028350 С2, 16.09.1982. ОЕ 1443462 А, 02.12.1970. ЕР 0204046 АЗ, 10.12.1988. (85) Дата перевода заявки РСТ на национальную фазу: 14.10.1998 (86) Заявка РСТ: ЕР 97/01124 (06.03.1997) (87) Публикация РСТ: МГО 97/33853 (18.09.1997) (98) Адрес для переписки: 103064, Москва, ул. Казакова, 16, НИИР - Канцелярия, "Патентные поверенные Квашнин, Сапельников и Партнеры", Квашнину В.П. (71) Заявитель: БАСФ АКЦИЕНГЕЗЕЛЛЬШАФТ (0Е) (72) Изобретатель: БРЕККЕР Франц Иозеф (0Е), ХЕССЕ Михаэль (ОЕ), МЭРКЛЬ Роберт (0Е) (73) Патентообладатель: БАСФ АКЦИЕНГЕЗЕЛЛЬШАФТ (0Е) (74) Патентный поверенный: Квашнин Валерий ...

New tri:methyl-(vinyl- or ethyl-butyl)-cyclohexanone derivatives

3,3,5-Trimethylcyclohexanone derivatives of formula (I) are new. X = CO or CH(OH); Y = CH(CH=CH2) or CH-(CH2CH3); or X+Y = CH-O-CH2-CH2-CH or CH-O-CH(CH3)-CH.