05-01-2012 дата публикации
Номер: US20120004165A1
Автор:
Stefanie KEIL,
Elisabeth DEFOSSA,
Viktoria DIETRICH,
Siegfried STENGELIN,
Andreas HERLING,
Guido HASCHKE,
Thomas KLABUNDE,
KEIL STEFANIE,
DEFOSSA ELISABETH,
DIETRICH VIKTORIA,
STENGELIN SIEGFRIED,
HERLING ANDREAS,
HASCHKE GUIDO,
KLABUNDE THOMAS
Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments 2. The compound as claimed in claim 1 , wherein{'sub': 1', '6', '3', '6', '1', '6', '3', '10, 'R1 is H, (C-C)-alkyl, (C-C)-cycloalkyl, (C-C)-alkylene-(C-C)-cycloalkyl, where the alkyl radical, alkylene radical and cycloalkyl radical may be mono- or polysubstituted by fluorine;'}{'sub': 1', '6', '1', '6, 'R2, R10 are each independently H, F, Cl, Br, CN, (C-C)-alkyl, O—(C-C)-alkyl, where the alkyl radical may be mono- or polysubstituted by fluorine;'}X is a bond, —O—, —S—, —(CR7R8)-;{'sub': 1', '2', '3', '4, 'B, B, B, Bare each independently —N— or —C(R9)-;'}{'sub': 1', '6', '3', '10', '1', '6', '3', '10, 'R3, R4, R7, R8 are each independently H, (C-C)-alkyl, (C-C)-cycloalkyl, (C-C)-alkylene-(C-C)-cycloalkyl, where the alkyl radical, alkylene radical and cycloalkyl radical may be mono- or polysubstituted by fluorine;'}{'sub': 2', '1', '6', '1', '6', '2', '3', '2', '2', '2', '1', '6', '2', '1', '6', '2', '2', '1', '6', '1', '6', '2', '5', '6', '10', '3', '10', '1', '6', '6', '10', '3', '10', '3', '1', '6', '1', '6', '5, 'R9 is H, F, Cl, Br, I, OH, NO, CN, O—(C-C)-alkyl, (C-C)-alkyl, SO—CH, SO—NH, SO—NH(C-C)-alkyl, SO—N((C-C)-alkyl), CONH, CONH(C-C)-alkyl, CON((C-C)-alkyl), SF, (C-C)-aryl, (C-C)-cycloalkyl, 4- to 12-membered heterocycle, where the (C-C)-alkyl radical, (C-C)-aryl radical, (C-C)-cycloalkyl radical, 4- to 12-membered heterocycle radical may be mono- or polysubstituted by F, Cl, Br, I, OH, CF, O—(C-C)-alkyl, (C-C)-alkyl, SF;'}n is 0, 1;and physiologically compatible salts thereof.3. The compound as claimed in claim 1 ,wherein{'sub': 1', '6, 'R1 is (C-C)-alkyl, where the alkyl radical may be mono- or polysubstituted by fluorine;'}{'sub': 1', '6', '1', '6, 'R2 is H, F, Cl, Br, CN, (C-C)-alkyl, O—(C-C)-alkyl, where the alkyl radical may be mono- or polysubstituted by fluorine;'}R10 is H;X is a bond, —O—, —S—, —(CR7R8)-;{' ...
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