06-02-2014 дата публикации
Номер: US20140038975A1
Принадлежит:
The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections. 2. The compound according to claim 1 , or a pharmaceutically acceptable salt thereof; [{'sup': '1', 'sub': 1', '3, 'Ris (C-C)alkyl;'}, {'sup': '2', 'sub': 1', '3, 'Ris (C-C)alkyl;'}, {'sup': '3', 'sub': 1', '3, 'Ris hydrogen or (C-C)alkyl;'}, 'X is N;', {'sup': '4', 'Y is N or CR;'}, {'sup': '4', 'sub': 1', '3, 'Ris hydrogen or (C-C)alkyl;'}, {'sub': 2', '6', '2', 'n', '2', 'p', '2', 'n', '2', 'p, 'L is a bond, (C-C)alkynylene, —(CH)O—(CH)—, or —(CH)S(CH)—;'}, 'n is 0, 1, or 2;', 'p is 0, 1, or 2;', {'sup': '7', 'sub': 1', '6', '6', '12', '5', '8', '3', '8', '5', '12', '3', '13, 'Ris (C-C)alkyl, (C-C)aryl, cyano, (C-C)cycloalkenyl, (C-C)cycloalkyl, (C-C)heteroaryl, or (C-C)heterocycle; and'}, {'sup': '8', 'sub': 6', '12', '6', '12', '1', '6', '3', '8', '5', '12, 'Ris absent, (C-C)aryl, (C-C)aryl(C-C)alkyl, (C-C)cycloalkyl, or (C-C)heteroaryl.'}], 'wherein3. The compound according to claim 1 , or a pharmaceutically acceptable salt thereof; [{'sup': '1', 'Ris methyl;'}, {'sup': '2', 'Ris methyl;'}, {'sup': '3', 'Ris hydrogen or methyl;'}, 'X is N;', {'sup': '4', 'Y is N or CR;'}, {'sup': '4', 'Ris hydrogen or methyl;'}, {'sub': 2', '6', '2', 'n', '2', 'p', '2', 'n', '2', 'p, 'L is a bond, (C-C)alkynylene, —(CH)O—(CH)—, or —(CH)S(CH)—;'}, 'n is 0, 1, or 2;', 'p is 0, 1, or 2;', {'sup': '7', 'sub': 6', '12', '6', '12', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6, 'Ris (C-C)aryl, wherein the (C-C)aryl is dihydroindenyl, naphthyl, phenyl, or tetrahydronaphthalenyl, wherein each is optionally substituted with 1, 2, or 3 substituents that are independently (C-C)alkoxy, (C-C)alkyl, (C-C)alkylthio, cyano, ethylenedioxy, halo(C-C)alkoxy, halo(C-C)alkyl, halogen, hydroxy, or oxo; and'}, {'sup': '8', 'sub': 3', '8', '5', '12, 'Ris absent, (C-C)cycloalkyl, or (C-C)heteroaryl.'}], 'wherein4. The compound ...
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