19-03-2020 дата публикации
Номер: US20200087266A1
Принадлежит:
Provided is a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and cancer including colorectal cancer. 4. The compound according to or a pharmaceutically acceptable salt thereof claim 1 , wherein X is CH.5. The compound according to or a pharmaceutically acceptable salt thereof claim 1 , wherein X is N.6. The compound according to or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris(1) chloro,(2) methyl,(3) cyano or(4) trifluoromethyl.7. The compound according to or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris hydrogen.8. The compound according to or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris{'sub': n', '2n', 'n', '2n, 'sup': b', 'b, 'claim-text': [{'sup': b1', 'b2, '(a) —C(O) NRR,'}, {'sup': b5', 'b6', 'b7, '(b) —NRC(O) NRR,'}, {'sup': b10', 'b11, 'sub': '2', '(c) —NRS(O)Ror'}, {'sup': b14', 'b15, '(d) —NRC(O)R'}], '—(CH)—R(n is 1 or 2, —(CH)— may be straight or branched chain, and Ris'}{'sup': b1', 'b2', 'b5', 'b6', 'b7', 'b10', 'b11', 'b14', 'b15, 'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '(R, R, R, R, R, R, R, R, and Rare as defined in )).'}9. The compound according to or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris —CH—R(Ris as defined in ).10. The compound according to or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris(1) halogen,(2) hydroxy,{'sub': '1-6', '(3) Calkyl or'}{'sup': c', 'c, 'sub': '1-6', 'claim-text': (a) halogen,', '(b) hydroxy,', {'sub': '1-6', '(c) Calkoxy,'}, {'sup': c1', 'c2', 'c1', 'c2, 'sub': '1-6', '(d) —C(O)NRR(Rand Rare each independently hydrogen or Calkyl),'}, (i) halogen,', '(ii) hydroxy,', {'sub': '1-6', '(iii) Calkyl,'}, {'sub': '1-6', '(iv) Calkoxy, and'}, {'sub': '1-4', '(v) haloCalkyl), and'}], '(e) phenyl ( ...
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